CN1234387C - Composition possessing lung clearing function and its preparation metod - Google Patents
Composition possessing lung clearing function and its preparation metod Download PDFInfo
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- CN1234387C CN1234387C CNB200410000254XA CN200410000254A CN1234387C CN 1234387 C CN1234387 C CN 1234387C CN B200410000254X A CNB200410000254X A CN B200410000254XA CN 200410000254 A CN200410000254 A CN 200410000254A CN 1234387 C CN1234387 C CN 1234387C
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a composition with the function of clearing the lung, which comprises fruits and stem leaves of tomato as active ingredients, or comprises water extracts and/or alcohol extracts of the fruits and the stem leaves of tomato as active ingredients. The composition can be made into beverages, food or medicine. The present invention also provides a preparation method of the composition with the function of clearing the lung, which comprises the following procedures: (1) selecting pollution-free tomato as a raw material, and collecting mellow fruits and stem leaves; (2) cleaning the fruits, adding a right amount of water and/or alcohol, steaming the solution, and collecting the solution to obtain the fruit extracting solution; (3) cleaning the stem leaves, adding a right amount of water and/or alcohol, steaming the solution, and collecting the solution to obtain the stem leaf extracting solution; (4) mixing the fruit extracting solution of the procedure (2) and the stem leaf extracting solution of the procedure (3) to obtain a mixed extracting solution; (5) adding the mixed extracting solution of the procedure (4) to appropriate carriers which can be accepted by human bodies to obtain the composition.
Description
Technical field
The present invention relates to a kind of composition and method of making the same, particularly a kind of composition and method of making the same with cleaning lung functions.
Background technology
After the SARS, people particularly pay attention to the health care of pulmonary.Lung is one of most important rabbit epidemic disease organ of human body, and smoking, passive smoking, environmental pollution, various harmful gas, virus, pathogenic bacteria at first encroaches on all is people's pulmonary, so in time clear up pulmonary, discharge poisonous and harmful substance, stopping the foundation of cancer illness, is primary body-care problem.
Hundred million smokers and more than 10 hundred million involuntary smoker surplus the whole world has 10 at present.World Health Organization (WHO) and World tobacco and health association all attach great importance to human smoking cessation and pulmonary's health care, because the sickness rate of pulmonary carcinoma is in the first place of all kinds of cancers always, and 80% lung cancer patient is the smoker.
Except that the smoker, also have the staff of many special trades (as the industry of generation industrial waste gas such as colliery, mining, cement, metallurgy, oil, chemical industry, rubber and dust pollution and traffic police, army, driver, cook, cleaner etc.) to press for and carry out pulmonary's cleaning health care and disease prevention.
The nearest achievement in research of U.S. scientist shows (American National ICR Philips Denis professor, the director John Ming Na of Harmon tumor research therapeutic community of Southwestern Medical Center of University of Texas professor, the cancer research personnel of Abramson family of the University of Pennsylvania, on January 7th, 2003, July 24, U.S.'s science site every day report), tar in the Nicotiana tabacum L. can be carcinogenic, and confirmed that the derivant of nicotine (NKK) in the cigarette directly contacts principle and the process that produces lung carcinoma cell behind the smog to pulmonary epithelial cells.
When people's smoking, nicotine and derivant thereof (NKK) stimulate pulmonary epithelial cells can activate a molecule AKt path and another Pim-2 path, and AKt path and Pim-2 path all are the main metabolic pathway of cancerous cell.AKt and Pim-2 promote the existence and the survival of cell, are the key enzymes of cancerous cell survival.In many tumors, the concentration of these two kinds of enzymes is all very high.
Under normal circumstances, the growth of human body cell and death are to be undertaken by the program of cell.The death of cell is one of effective mechanism of human body defence cancer.Human body cell can running check they whether be in " normal condition ", can commit suiside at any time in case find any abnormal phenomena, protect main body with this, prevent the free breeding of unusual cell and form tumor.The breeding of cancerous cell and diffusion will destroy apoptosis (death) program of human body cell, activate AKt and will then have become to promote cancerous cell survival and the approach that spreads with the Pim-2 path, so nicotine in the Nicotiana tabacum L. and derivant (NKK) can directly cause the generation of cancer.
China scientist has found also that from the flue gas of smoking carbon monoxide, carbon dioxide and other contain the multiple harmful substances of alkyl and alkoxyl, are called free radical.This free radical can destroy the cell membrane of human body, and the human serum protease inhibitor is lost activity, and the gene that can damage the people causes cytometaplasia and accumulates the i.e. generation of cancerous cell and diffusion.
Smoking, vehicle exhaust, kitchen fume and industrial waste gas all are the harm maximums that free-radical contents higher gas, particularly smoker are subjected to free radical.Human some important diseases such as cardiovascular disease, respiratory system disease, cancer and skin premature aging etc. all have direct relation with the harm that is subjected to free radical, particularly the free radical in the smoke from cigarette.
Aspect cleaning pulmonary, mainly contain at present eliminate the phlegm, alleviate or prevents cough, the medicine of the class of panting, title reduces phlegm, cough-relieving, anti-asthmatic.This class medicine is mainly used in the abundant expectoration cough, phlegm retention is panted and the symptom relevant with phlegm retention.This quasi-medicated property is warm or cold, goes into lung, the heart, spleen, stomach large intestine channel more.
The traditional Chinese medical science has the branch of broad sense and narrow sense to the understanding of expectorant, and generalized expectorant refers to stop amassing various phlegm syndromes between the internal organs meridians, is common in diseases such as subcutaneous lump in the modern medicine, chronic lymphadenitis, simple goiter.The expectorant of narrow sense refers to the expectorant of respiratory tract expectoration, is more common in pulmonary's illness such as upper respiratory tract infection, acute/chronic bronchitis, emphysema, bronchiectasis.The person that generally do not bring up phlegm when one coughs is many, and abundant expectoration easily causes cough with asthma.Therefore, expectorant, cough, to breathe heavily triadic relation close, reciprocal causation.
The cough-relieving of expectorant multipotency, and cough-relieving, anti-asthmatic have resolve phlegm effect concurrently more.So their effect is difficult to clearly distinguish with corresponding selectivity pharmacological action.Modern pharmacological research shows, reduces phlegm, cough-relieving, the effect of relievining asthma relevant with following pharmacological action (referring to pharmacology of Chinese materia medica, China Traditional Chinese Medicine Publishing House, Beijing, in August, 2002).
(1) phlegm-dispelling functions
The decoct or the fluid extract of Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Radix Asteris, Fructus Gleditsia, Rhizoma Arisaematis, Flos Farfarae, Folium Rhododendri Daurici etc. all have phlegm-dispelling functions, can both increase the secretory volume of respiratory tract, generally act on after 1 hour in administration and peaking, wherein Radix Platycodonis, Radix Peucedani, Fructus Gleditsia effect are the strongest, and Flos Farfarae a little less than.Above medicine is except that Folium Rhododendri Daurici contains farrerol, and the phlegm-dispelling functions of all the other medicines is how relevant with contained Saponin.Saponin can stimulate stomach or throat mucosa, causes mild nausea reflectingly, increases the secretion of bronchus body of gland, thus dilution sputum and bring into play phlegm-dispelling functions.The phlegm-dispelling functions of farrerol is then different with Saponin, can promote trachea mucus-ciliary movement on the one hand, strengthen respiratory tract and remove the function of foreign body, solubilized sticks expectorant on the other hand, make acid mucopolysaccharide fibrous fracture in the respiratory secretions, reduce sialic content simultaneously, the thick sputum degree is descended, be easy to bring up.
(2) antitussive action
The Rhizoma Pinelliae, Semen Armeniacae Amarum, Radix Platycodonis, Flos Farfarae, Bulbus Fritillariae Uninbracteatae, the Radix Stemonae, Folium Rhododendri Daurici, Radix Asteris etc. all have the antitussive effect of varying degree.The antitussive effect position of the Rhizoma Pinelliae, Semen Armeniacae Amarum, Flos Farfarae, Bulbus Fritillariae Uninbracteatae, the Radix Stemonae etc. may be the central nervous system.
(3) antiasthmatic effect
Bulbus Fritillariae Thunbergii, Semen Armeniacae Amarum, Flos Farfarae, Folium Eriobotryae etc. have certain expansion bronchus effect.The antiasthmatic effect mechanism of Chinese medicine also is many-sided, and peimine can expand that family exempts from, the bronchial smooth muscle of cat, directly suppresses bronchospasm with relieving asthma symptoms.The Flos Farfarae ether extract mechanism of relievining asthma may save relevant with excitor nerve.Kikyosaponin, Flos Farfarae ether extract can suppress guinea pig bronchial spasm due to the histamine, and its effect may be relevant with antiallergic.
Though at present existingly reduce phlegm, cough-relieving, anti-asthmatic can play certain lung heat clearing function, can not clear up pulmonary completely, more can not thoroughly eliminate the rabat perspective shadow of the pulmonary infection due to a variety of causes.So, have scientist to propose, need a kind of new therapy or new drug thoroughly to clear up pulmonary, the survival of interference lung carcinoma cell, and cancerous cell transformation be fatal tumor and be diffused into other positions of health before it is killed.
Fructus Lycopersici esculenti has another name called Fructus Lycopersici esculenti, has abundant material source, but the purposes of present known Fructus Lycopersici esculenti mainly is the raw material of food, and is still medicinal its exploitation is used for, and more its exploitation is not used for the report of lung heat clearing.
Summary of the invention
The invention provides a kind of compositions with lung heat clearing function, it contains the fruit of Fructus Lycopersici esculenti and stem and leaf as active component, perhaps contains the water of the fruit of Fructus Lycopersici esculenti and stem and leaf and/or alcohol extract as active component.Described extract can be to use existing various common extracting method to prepare, and wherein preferred water steaming and decocting, uses pure steaming and decocting.
Above-mentioned compositions of the present invention can be to make the form of beverage, food or medicine.Wherein, preferred beverage form is beverage, wine, drinking water, more preferably oral liquid; Preferred food form is bread, cookies, noodles, cake, medicated porridge, rice, steamed bread, steamed bread of corn; Preferred medicine form is an oral formulations, more preferably oral liquid, tablet, pill, capsule.
Above-mentioned compositions the best of the present invention is to make the form of oral liquid.
Above-mentioned compositions of the present invention can also contain flavoring agent, preferably one or more in sweeting agent, stop mouthful agent and the bitter remover, more preferably one or more in protein sugar, xylitol, sucrose, aspartame, Mel, second class maltol, malic acid, citric acid, stop mouthful agent and the bitter remover.
Above-mentioned compositions of the present invention can also contain Rhizoma Zingiberis Recens, Herba Leonuri and the Radix Astragali, perhaps the water of one or more in them and/alcohol extract.
The present invention also provides a kind of preparation of compositions method with lung heat clearing function, and it may further comprise the steps:
(1) chooses free of contamination Fructus Lycopersici esculenti as raw material, gather mellow fruit and stem and leaf;
(2) clean fruit, add suitable quantity of water and/or alcohol and carry out steaming and decocting, collect solution, make fruit extracting solution;
(3) clean stem and leaf, add suitable quantity of water and/or alcohol and carry out steaming and decocting, collect solution, make the stem and leaf extracting solution;
(4) fruit extracting solution with step (2) mixes with the stem and leaf extracting solution of step (3), makes the extracting solution of Fructus Lycopersici esculenti;
(5) tomato extract solution of step (4) is added in the acceptable suitable carrier of human body make compositions.
In above-mentioned preparation of compositions method, the alcohol described in step (2) and the step (3) is ethanol preferably.
In above-mentioned preparation of compositions method, the steaming and decocting described in the step (2) is preferably at 80-100 ℃ of steaming and decocting 5-20 minute, and the steaming and decocting described in the step (3) is preferably at 80-120 ℃ of steaming and decocting 10-30 minute.
In above-mentioned preparation of compositions method, the weight ratio of the water described in the step (2) and/or alcohol and described fruit preferably is about 1-3: 1, and the weight ratio of the water described in the step (3) and/or alcohol and described stem and leaf preferably is about 2-4: 1.
In above-mentioned preparation of compositions method, the weight ratio of the stem and leaf described in fruit described in the step (2) and the step (3) preferably is about 0.1-1: 1.
In above-mentioned preparation of compositions method, the compositions in the step (5) can be to make the form of beverage, food or medicine.Wherein, preferred beverage form is beverage, wine, drinking water, more preferably oral liquid; Preferred food form is bread, cookies, noodles, cake, medicated porridge, rice, steamed bread, steamed bread of corn; Preferred medicine form is an oral formulations, more preferably oral liquid, tablet, pill, capsule.
In above-mentioned preparation of compositions method, compositions the best is to make the form of oral liquid in the step (5).
In above-mentioned preparation of compositions method, compositions can also contain flavoring agent in the step (5), preferably one or more in sweeting agent, stop mouthful agent and the bitter remover, more preferably one or more in protein sugar, xylitol, sucrose, aspartame, Mel, second class maltol, malic acid, citric acid, stop mouthful agent and the bitter remover.
In above-mentioned preparation of compositions method, compositions can also contain Rhizoma Zingiberis Recens, Herba Leonuri and the Radix Astragali in the step (5), perhaps the water of one or more in them and/extract of alcohol.
Compositions applicable object with lung heat clearing function of the present invention comprises:
(1) smoking and involuntary smoker
(2) old people
(3) women, child
(4) special trade practitioner.
Usage with compositions of lung heat clearing function of the present invention is:
(1) takes the next day that pulmonary polluting than the lighter, contain the 100-150g stem and leaf in the compositions of taking every day, perhaps contain the extracting solution for preparing according to the method described above by the 100-150g stem and leaf, took continuously 1 month;
(2) the heavier person of pulmonary's pollution symptom takes every day, contains the 100-150g stem and leaf in the compositions of taking every day, perhaps contains the extracting solution that is prepared according to the method described above by the 100-150g stem and leaf, takes continuously 1 month.
The fruit and the stem and leaf that contain Fructus Lycopersici esculenti in the compositions of the present invention perhaps contain the fruit of Fructus Lycopersici esculenti and the water and/or the alcohol extract of stem and leaf, and active component wherein is mainly farrerol and Saponin, have eliminate the phlegm, the effect of cough-relieving, raise immunity; Farrerol wherein can promote trachea mucus-ciliary movement on the one hand, strengthens the function that respiratory tract is eliminated foreign body, on the other hand the glutinous expectorant of solubilized, make acid mucopolysaccharide fibrous fracture in the respiratory secretions, reduce sialic content simultaneously, the thick sputum degree is descended, be easy to bring up.The more important thing is, also contain in the compositions of the present invention and can play synergistic cofactor with farrerol and Saponin, it can promote the physiological function of farrerol and Saponin, and act on pulmonary by blood circulation together, thereby nicotine derivant (NKK) and other free radicals to pulmonary are effectively cleared up, stopped the stimulation of NKK to pulmonary epithelial cells, cancerous cell rely active AKt and Pim path have been got rid of, prevent the generation of pulmonary carcinoma, strengthened the ability that pulmonary resists external infringement simultaneously.
Because cleared up harmful substance, free radical is accumulated pulmonary, the blood vessel of pulmonary and pneumonocyte are in a kind of pure and fresh free of contamination state fully, the definition of lung x-ray photograph is just like normally, expectorant is dirty to disappear, and cough with asthma, has uncomfortable in chestly also disappeared.
Simultaneously, also have effects such as relieving constipation, heat-clearing and toxic substances removing, antiinflammatory in the compositions of the present invention.
Compositions with lung heat clearing function of the present invention from later 1940s early fifties existing so far five more than ten years history, number of users can't accurately be added up, but has exceeded ten thousand people meter.Shenzhen in 1997 just had people more than 300 to take in one month, mainly was smoker and miner, also had the cold cough person.On February 25th, 2003 drank more than existing so far 150 people in Beijing, and curative effect is all good.
Compositions with lung heat clearing function of the present invention, under the situation of not taking other medicines, through Shenzhen, the people of different lengths of smoking of Beijing example up to a hundred (several years at least, more than ten years, decades) at most takes, week then soon, slowly then month surplus, the abundant expectoration, cough, asthma, uncomfortable in chest can the recovery from illness that cause because of smoking; The fuzzy shade that pulmonary forms because of long-term contact smog (it is swollen thing that diagnosis is got rid of) also disappears thereupon, and lung x-ray photograph shows normal definition.
Active substance in the compositions of the present invention the have drawn from fruit and the plant stem-leaf of Fructus Lycopersici esculenti, the source is abundant, have no side effect, the injury that it causes because of smoking and air pollution pulmonary, have quick repair and expectoration, cough-relieving function, pollutant in the lobe of the lung, the trachea were discharged in a few hours, solved insoluble in the world at present problem, this invention is creationary and epoch-making.
The deputy director of China Medical Sciences Academy Medical Plants Institute, the Liu Cheng that is engaged in the medicinal plants research and development for a long time comes professor to point out, compositions of the present invention can play the effect of quick lung heat clearing to 100% the polluter of severe pulmonary in 1 month short time, the slight polluter of pulmonary more than 90% is played the effect of quick lung heat clearing, this medically is being very rare, its exploitation is worth very huge, the medicine that market in urgent need is such, in case listing, it will be to the smoker, involuntary smoker (the women of passive smoking especially, the child) and to be subjected to the crowd of air pollution harm be great Gospel.
Beijing ZhaoYang Hospital Pneumology Department director Guo Xiheng points out that the cleaning of inhaling desorption system is a world-famous puzzle always.The cough-relieving in past, the class of eliminating the phlegm medicine can only play the effect of expansion trachea, relief of symptoms, and can't make pulmonary and respiratory system recover normal function.Compositions of the present invention is just remedying this defective, fundamentally improves pulmonary function, makes pulmonary recover original appearance, respiratory system is intact.
The Wang Dali doctor of Mentougou pneumosilicosis section hospital (SHILONG hospital) thinks, pneumosilicosis patient will make pulmonary recover normal, make great efforts all to be difficult to reach through many decades, compositions of the present invention can be more than with regard to breathing, expectoration difficulty, the chronic cough that thoroughly improve pneumosilicosis patient in the so short time, so that the various symptoms of pulmonary heart disease, really accomplish something difficult and so deserve praise, this will make thousands of pneumosilicosis patient, coal miner be benefited.
The president Li Mushi of Korea S alternative medicine between east and west research association thinks that compositions of the present invention is good medicine to the smoking people, and market is very big.The trial target of compositions of the present invention all is that Aisan is receptible from the function to the taste, and is rising.
The lung heat clearing effect that World Health Organization (WHO) and the trier of World tobacco and health association and all compositionss of the present invention be consistent to affirm compositions of the present invention is unique in the world smoking and air-polluting jinx at present.
The specific embodiment
The following examples will be further explained the present invention, but the present invention is not limited only to these embodiment, the scope that these embodiment do not limit the present invention in any way.Some change that those skilled in the art is made within the scope of the claims and adjust also should be thought and belongs to scope of the present invention.
The oral liquid that embodiment 1 preparation has the lung heat clearing function
(1) raw material screening: require plant strain growth ground solar radiation abundance, soil, environmental nonpollution (pollution of pesticide, chemical fertilizer), no disease and pest, plant strain growth is good, the completely filled fruit maturation; Collecting fruit 20kg, stem and leaf 20kg;
(2) clean fruit, add the water of 40kg,, collect solution, make fruit extracting solution 39kg 100 ℃ of steaming and decoctings 10 minutes;
(3) clean stem and leaf, add the water of 60kg,, collect solution, make stem and leaf extracting solution 58kg 120 ℃ of steaming and decoctings 20 minutes;
(4) fruit extracting solution with step (2) mixes with the stem and leaf extracting solution of step (3), makes mixed extract 97kg;
(5) mixed extract with step (4) concentrates, and makes 60 liters of oral liquids, adds a small amount of protein sugar and bitter remover, is distributed into every bottle of fractional pack that contains 300ml.
The oral liquid that embodiment 2 preparations have the lung heat clearing function
(1) chooses free of contamination Fructus Lycopersici esculenti as raw material, collecting fruit 10kg, stem and leaf 40kg;
(2) clean fruit, add the water of 10kg,, collect solution, make fruit extracting solution 9kg 80 ℃ of steaming and decoctings 20 minutes;
(3) clean stem and leaf, add the water of 80kg,, collect solution, make stem and leaf extracting solution 79kg 80 ℃ of steaming and decoctings 30 minutes;
(4) fruit extracting solution with step (2) mixes with the stem and leaf extracting solution of step (3), makes mixed extract 88kg;
(5) mixed extract with step (4) concentrates, and makes 80 liters of oral liquids, adds a small amount of Mel and mouthful agent of stopping, and is distributed into every bottle of fractional pack that contains 300ml.
The oral liquid that embodiment 3 preparations have the lung heat clearing function
(1) chooses free of contamination Fructus Lycopersici esculenti as raw material, collecting fruit 20kg, stem and leaf 30kg;
(2) clean fruit, add the water of 60kg,, collect solution, make fruit extracting solution 58kg 90 ℃ of steaming and decoctings 20 minutes;
(3) clean stem and leaf, add the water of 120kg,, collect solution, make stem and leaf extracting solution 118kg 110 ℃ of steaming and decoctings 15 minutes;
(4) fruit extracting solution with step (2) mixes with the stem and leaf extracting solution of step (3), makes mixed extract 176kg;
(5) mixed extract with step (4) concentrates, and makes 90 liters of oral liquids, adds a small amount of aspartame, citric acid, bitter remover, Herba Leonuri and the Radix Astragali, is distributed into every bottle of fractional pack that contains 300ml.
The oral liquid that embodiment 4 preparations have the lung heat clearing function
(1) chooses free of contamination Fructus Lycopersici esculenti as raw material, collecting fruit 10kg, stem and leaf 30kg;
(2) clean fruit, add the water of 15kg,, collect solution, make fruit extracting solution 14kg 100 ℃ of steaming and decoctings 10 minutes;
(3) clean stem and leaf, add the water of 60kg,, collect solution, make stem and leaf extracting solution 58kg 120 ℃ of steaming and decoctings 20 minutes;
(4) fruit extracting solution with step (2) mixes with the stem and leaf extracting solution of step (3), makes mixed extract 72kg;
(5) mixed extract with step (4) concentrates, and makes 60 liters of oral liquids, adds a small amount of protein sugar, is distributed into every bottle of fractional pack that contains 300ml.
The oral liquid that embodiment 5 preparations have the lung heat clearing function
(1) chooses free of contamination Fructus Lycopersici esculenti as raw material, collecting fruit 10kg, stem and leaf 30kg;
(2) clean fruit, add the water of 25kg,, collect solution, make fruit extracting solution 24kg 100 ℃ of steaming and decoctings 13 minutes;
(3) clean stem and leaf, add the water of 90kg,, collect solution, make stem and leaf extracting solution 98kg 120 ℃ of steaming and decoctings 15 minutes;
(4) fruit extracting solution with step (2) mixes with the stem and leaf extracting solution of step (3), makes mixed extract 122kg;
(5) mixed extract with step (4) concentrates, and makes 90 liters of oral liquids, adds a small amount of xylitol, malic acid and bitter remover, is distributed into every bottle of fractional pack that contains 300ml.
The wine of drinking that embodiment 6 preparations have the lung heat clearing function
(1) chooses free of contamination Fructus Lycopersici esculenti as raw material, collecting fruit 6kg, stem and leaf 60kg;
(2) clean fruit, add the ethanol of 10kg 50%,, collect solution, make fruit extracting solution 9kg 90 ℃ of steaming and decoctings 15 minutes;
(3) clean stem and leaf, add the ethanol of 120kg 50%,, collect solution, make stem and leaf extracting solution 118kg 100 ℃ of steaming and decoctings 20 minutes;
(4) fruit extracting solution with step (2) mixes with the stem and leaf extracting solution of step (3), makes mixed extract 127kg;
(5) mixed extract with step (4) concentrates, and makes 120 liters of oral liquids, adds a small amount of Rhizoma Zingiberis Recens, xylitol, malic acid and bitter remover, is distributed into every bottle of fractional pack that contains 300ml.
The wine of drinking that embodiment 7 preparations have the lung heat clearing function
(1) chooses free of contamination Fructus Lycopersici esculenti as raw material, collecting fruit 8kg, stem and leaf 20kg;
(2) clean fruit, add the ethanol of 16kg 20%,, collect solution, make fruit extracting solution 15kg 100 ℃ of steaming and decoctings 5 minutes;
(3) clean stem and leaf, add the ethanol of 60kg 10%,, collect solution, make stem and leaf extracting solution 59kg 120 ℃ of steaming and decoctings 20 minutes;
(4) fruit extracting solution with step (2) mixes with the stem and leaf extracting solution of step (3), makes mixed extract 74kg;
(5) mixed extract with step (4) concentrates, and makes 50 liters of oral liquids, adds a small amount of second class maltol and mouthful agent of stopping, and is distributed into every bottle of fractional pack that contains 300ml.
The food that embodiment 8 preparations have the lung heat clearing function
Respectively the food technology of the middle mixed extract for preparing of the step (4) of embodiment 1,2,3 according to routine joined in the food, make the bread, cookies, noodles, cake, medicated porridge, rice, steamed bread, the steamed bread of corn that contain Fructus Lycopersici esculenti extract of the present invention.
The medicine that embodiment 9 preparations have the lung heat clearing function
Respectively the medicine technology of the middle mixed extract for preparing of the step (4) of embodiment 1,2,3 according to routine is joined in the medicine, make the tablet, pill, the capsule that contain Fructus Lycopersici esculenti extract of the present invention.
The clinical lung heat clearing observation on effect of embodiment 10 compositionss of the present invention
Respectively the oral formulations of embodiment 1-7 preparation is used for clinically, carries out the lung heat clearing observation on effect.
(1) physical data
150 people drink, wherein male 120 people, and women 30 people, M-F is 4: 1.Age 1-2 year 5 people, 12-16 year 15 people, 17-30 year 25 people, 30-50 year 80 people, 51-79 year 25 people.Its middle school student 30 people, deskman 25 people, miner 50 people, doctor 10 people, retired person 10 people, police 5 people, teacher 10 people, contractor 10 people.
(2) diagnostic criteria
The tcm diagnosis standard
Have for a long time (more than 3 years) or the cold cough person cough for a long time of smoking history (more than 5 years) or contact dust take place frequently, abundant expectoration is difficult for bringing up, and majority have cough, and a few peoples are with slight low grade fever, and the nocturnal cough increases the weight of, and difficulty uncomfortable in chest is fallen asleep.Postinfectious cough increases the weight of, obstinate.Majority's dry pharynx tongue is hot-tempered, constipation or long-term chronic pharyngitis, red tongue or deep red, yellow and greasy fur or thick, full and rapid pulse or count accurately.
The Western medicine diagnose standard
A., smoking history more than 5 years is arranged, or contact dust more than 3 years, or often suck contaminated air, or flu causes cough with asthma;
B. cough for a long time, abundant expectoration is difficult for bringing up, and the patient who has can be with 37.5-38 ℃ low grade fever or cough with asthma;
C. chest films showed pulmonary texture strengthens and is disorderly, and fuzzy shade is arranged, and most of patients is diagnosed as peribronchitis;
D. the expectorant antibacterial culturing is found, it is that various bacteria infects that 60% patient is arranged, and only a few patient has the lung aspergillosis to infect.
(3) Therapeutic Method
Choose male 50 people, women 20 people that are fond of drinking, drink the wine of drinking of embodiment 6,7 preparations respectively, severe symptom is taken every day, day clothes 3 times, and each 100ml, 30 days is 1 course of treatment; Take the next day of symptom the lighter, day clothes 3 times, each 100ml, 30 days is 1 course of treatment;
All the other 80 people drink the oral liquid of embodiment 1-5 preparation respectively, and severe symptom is taken every day, day clothes 3 times, and each 100ml, 30 days is 1 course of treatment; Take the next day of symptom the lighter, day clothes 3 times, each 100ml, 30 days is 1 course of treatment.
(4) efficacy assessment standard
Recovery from illness: after oral 3 days, cough, dense black expectorant mostly bring up, no longer cough after 7 days, and idol has expectorant to bring up; Uncomfortable in chest after 15 days, productive cough disappears, and breathes smooth and easy; The two lungs of chest films showed clear (fuzzy shape shade is eliminated) are normal person's breast sheet after 30 days;
Produce effects: after oral 3 days, cough, dense black expectorant mostly brings up, and idol has cough after 15 days, breathes smooth and easyly, and the two lungs of chest films showed clear (bluring the shape shade is eliminated) are normal person's breast sheet after 30 days;
Invalid: as not reach improvement standard person.
The clinical efficacy result of the oral formulations of embodiment 1-7 preparation is as shown in table 1, and it is as shown in table 2 that patient's sign is improved situation.
The clinical efficacy result of table 1 oral formulations of the present invention
| Treatment time (my god) | Produce effects | Recovery from illness | Invalid | Effective percentage (%) | |||
| The example number | Obvious effective rate (%) | The example number | Cure rate (%) | The example number | Inefficiency (%) | ||
| 3 | 135 | 90 | - | - | 0 | 0 | 90 |
| 7 | 141 | 94 | - | - | 0 | 0 | 94 |
| 15 | 144 | 96 | - | - | 0 | 0 | 96 |
| 30 | - | - | 150 | 100 | 0 | 0 | 100 |
Table 2 patient's sign is improved situation
| Symptom | The pharyngalgia xerostomia | Cough with copious phlegm | Chest distress | Back is ached, is had a headache | Difficult sleeping |
| Before the treatment (example) | 144 | 150 | 75 | 135 | 105 |
| Treatment back (example) | 3 | 0 | 2 | 4 | 3 |
| Effective percentage (%) | 98 | 100 | 97 | 97 | 97 |
From the result of table 1 as can be seen, the patient takes the oral liquid of embodiment 1-7 preparation and drinks wine, only need just can to make in 3 days up to 90% patient be improved significantly, it is very fast to take effect; In the time of 30 days, the patient all fully recovers, and effective percentage reaches 100%.
From the result of table 2 as can be seen, the oral liquid of embodiment 1-7 preparation and drink wine and can alleviate effectively that pharyngalgia xerostomia, cough with copious phlegm, chest distress, back are ached, have a headaches, difficult symptom such as fall asleep, effective percentage reaches more than 97%.
The clinical lung heat clearing observation on effect of embodiment 11 compositionss of the present invention
The medicine of the food of embodiment 8 preparation, embodiment 9 preparations is used for clinical, carries out the lung heat clearing observation on effect.
(1) physical data
100 people take, wherein male 80 people, and women 20 people, M-F is 4: 1.Age 5-16 year 10 people, 17-30 year 15 people, 30-50 year 40 people, 51-78 year 35 people.Its middle school student 21 people, deskman 15 people, miner 43 people, doctor 11 people, retired person 10 people.
(2) diagnostic criteria
With embodiment 10.
(3) Therapeutic Method
The patient is divided into 2 groups, and every group 50 people takes the food of embodiment 8 preparations and the medicine of embodiment 9 preparations respectively; Take the next day that pulmonary polluting than the lighter, contain extracting solution in the compositions of taking every day, took continuously 1 month by the preparation of 100-150g stem and leaf; The heavy contamination person of pulmonary takes every day, contains the extracting solution by the preparation of 100-150g stem and leaf in the compositions of taking every day, takes continuously 1 month;
(4) efficacy assessment standard
With embodiment 10.
The clinical efficacy result of the medicine of the food of embodiment 8 preparations and embodiment 9 preparations is as shown in table 3, and it is as shown in table 4 that patient's sign is improved situation.
The clinical efficacy result of table 3 oral formulations of the present invention
| Treatment time (my god) | Produce effects | Recovery from illness | Invalid | Effective percentage (%) | |||
| The example number | Obvious effective rate (%) | The example number | Cure rate (%) | The example number | Inefficiency (%) | ||
| 3 | 91 | 91 | - | - | 0 | 0 | 91 |
| 7 | 93 | 93 | - | - | 0 | 0 | 93 |
| 15 | 96 | 96 | - | - | 0 | 0 | 96 |
| 30 | - | - | 100 | 100 | 0 | 0 | 100 |
Table 4 patient's sign is improved situation
| Symptom | The pharyngalgia xerostomia | Cough with copious phlegm | Chest distress | Back is ached, is had a headache | Difficult sleeping |
| Before the treatment (example) | 86 | 100 | 70 | 67 | 76 |
| Treatment back (example) | 2 | 0 | 2 | 4 | 5 |
| Effective percentage (%) | 98 | 100 | 97 | 94 | 93 |
From the result of table 3 as can be seen, the patient takes the food of embodiment 8 preparations and the medicine of embodiment 9 preparations, only need just can to make in 3 days up to 91% patient be improved significantly, it is very fast to take effect; In the time of 30 days, the patient all fully recovers, and effective percentage reaches 100%.
From the result of table 4 as can be seen, the medicine of the food of embodiment 8 preparations and embodiment 9 preparations can alleviate effectively that pharyngalgia xerostomia, cough with copious phlegm, chest distress, back are ached, have a headaches, difficult symptom such as fall asleep, and effective percentage reaches more than 93%.
Embodiment 12 contrast experiments
Buying commercially available respectively is following active components Chinese medicine with Saponin or farrerol: Herba Houttuyniae, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii, Semen Armeniacae Amarum, Folium Rhododendri Daurici, Radix Peucedani, Fructus Gleditsia, Rhizoma Arisaematis, Radix Glycyrrhizae; Above medicine is pressed Chinese medicine prescription monarch principle prescription, and is used in combination cephalo series antibiotic, takes group in contrast for 100 patients according to their conventional process, and the efficacy result when taking 3 days, 7 days, 15 days and 30 days is as shown in table 5.
The clinical efficacy result of table 5 Chinese medicine
| Treatment time (my god) | Eliminate the phlegm | Cough-relieving | Remove the fuzzy shade of pulmonary | Eliminate pneumonia | ||||
| The example number | Effective percentage (%) | The example number | Effective percentage (%) | The example number | Effective percentage (%) | The example number | Effective percentage (%) | |
| 3 | 20 | 20 | 15 | 15 | 0 | 0 | 0 | 0 |
| 7 | 50 | 50 | 45 | 45 | 0 | 0 | 15 | 15 |
| 15 | 85 | 85 | 75 | 75 | 0 | 0 | 70 | 70 |
| 30 | 95 | 95 | 90 | 90 | Part alleviates 10 | 10 | 92 | 92 |
As can be seen from Table 5, medication just can show the eliminating phlegm and stopping cough curative effect in the time of 7 days, medication in the time of 30 days the eliminating phlegm and stopping cough curative effect more obvious, but the fuzzy shade of chest films showed pulmonary still exists, and also is difficult to eliminate pneumonia.Cough in order to last medicine person that to bring up black expectorant person few.
In experimental group, take the compositions of embodiments of the invention 1-9 preparation for 100 patients, above Chinese medicine all need not.Efficacy result when taking 3 days, 7 days, 15 days and 30 days is as shown in table 6.
The clinical efficacy result of table 6 present composition
| Treatment time (my god) | Eliminate the phlegm | Cough-relieving | Remove the fuzzy shade of pulmonary | Eliminate pneumonia | ||||
| The example number | Effective percentage (%) | The example number | Effective percentage (%) | The example number | Effective percentage (%) | The example number | Effective percentage (%) | |
| 3 | 70 | 70 | 60 | 60 | 0 | 0 | 10 | 10 |
| 7 | 85 | 85 | 75 | 75 | 10 | 10 | 45 | 45 |
| 15 | 90 | 90 | 95 | 95 | 50 | 50 | 65 | 65 |
| 30 | 98 | 98 | 100 | 100 | 100 | 100 | 100 | 100 |
As can be seen from Table 6, most of patients after 24 hours, can bring up more black expectorant with compositions of the present invention, fast person promptly brings up black expectorant within an hour, drinks compositions of the present invention in the time of 30 days, and chest films showed pulmonary is clear normal, the fuzzy shade of pulmonary disappears, and pneumonia also disappears.
Experiment showed, cofactor in the compositions of the present invention promoted farrerol and Saponin biological activity, thereby compositions of the present invention not only possesses good quick cough-relieving, expectorant effect, and has the effect of removing pulmonary shadow, diminishing inflammation.
The clinical lung heat clearing observation on effect of embodiment 13 compositionss of the present invention
In the observation of the clinical effectiveness of compositions of the present invention, the part test result is as follows:
Korea Spro, man 47 years old, smoking 28 years, every day average 2 bag cigarettes, abundant expectoration and difficulty bring up, cough, hypopnea, the time have uncomfortable in chest, more than ten years.Be unable to do without aminophylline, Radix Glycyrrhizae tabellae every day, otherwise can not fall asleep.The People's Hospital's rabat shows: the right lung fuzzy shade of strip of marching off into political wilderness; Impression: right lung peribronchitis.Take compositions of the present invention second day promptly stop using Radix Glycyrrhizae tabellae, aminophylline, expectorant easily brings up, though continue smoking, no longer cough, it is surplus to drink the oral liquid moon of the present invention, and rabat shows that two lungs are clear and bright, impression: chest no abnormality seen.
Go into business certain, the man, 15 years old, Concord Hospital's Pneumology Department diagnosis pulmonary infection ABPA probability was big, symptom: cough, abundant expectoration and smelly is interrupted heating, and rabat shows migration shade in the lung, once at the Pneumology Department hospitalization.It is year surplus that the back state of an illness of leaving hospital is still shown effect before and after the medical history repeatedly, drinks oral liquid of the present invention state of an illness control after 15 days, and it is surplus to drink the oral liquid moon of the present invention, and rabat shows that two lung fields are clear, diagnostic comments: cardiopulmonary diaphragm no abnormality seen.
Liu, the man, 53 years old, smoking 15 years was breathed with cough, the difficulty of coughing up phlegm, in the time, have uncomfortable in chestly, drinks 300 milliliters of oral liquids of the present invention, and after one day, productive cough is with ending.All are normal in continuous drink one all backs.
Lee, the woman, 49 years old, smoking 10 years, cough, the expectorant difficulty brings up, and hypopnea was drunk oral liquid of the present invention second day, brought up a large amount of sputums, and respiratory passage unblocked is with not coughing.Continuous drink one week recovery from illness.
The side certain, the man, 23 years old, cat fever caused abundant expectoration cough, controls for a long time and does not heal, and drinks 300 milliliters of oral liquids of the present invention, productive cough is with ending after one day.The recovery from illness in three days of continuous drink.
Turn round and look at certain, the woman, 61 years old, Shen, the woman, 21 years old, Xu certain, the woman, 21 years old, the classmate lived a dormitory together, flu infects mutually cough with copious phlegm, the Zhou Buyu that takes medicine, after each drank 300 milliliters of oral liquids of the present invention, the abundant expectoration cough was all healed.
Zhu, the man, 42 years old, smoking 9 years, chest distress, the time arrhythmia is arranged, obey oral liquid of the present invention after 10 days, discharge black expectorant gradually, chest distress takes a turn for the better, and breathes smooth and easyly, the rhythm of the heart is normal.
Ma, the woman, 35 years old, the head nurse, SARS more after, the lung rabat shows starlike fibrosis, hypopnea, action is painstaking, drinks compositions of the present invention 10 days, breathe obviously unobstructed, freedom of movement.
Zhang, the man, 79 years old, smoking 60 years played cough with asthma morning every day 1 hour, and expectorant still difficulty brings up, and the drink lung heat clearing plays cough with asthma and obviously alleviates after 3 days morning, and continuous drink is after 10 days, and expectorant brings up very soon, and cough with asthma is healed entirely.
Wei, the man, 47 years old, dug up mine 10 years, smoking 20 years, cough with copious phlegm, hypopnea 3 years, weight loss, rabat shows: two lungs blur shape shade (eliminating pulmonary carcinoma), and it is surplus to drink the compositions moon of the present invention, and the rabat check: two diaphragms are clear, and cough with copious phlegm is all healed.It is surplus to introduce 15 ore deposit friend drink compositions moons of the present invention, and cough with copious phlegm is also healed entirely.
Claims (10)
1. the compositions with lung heat clearing function is characterized in that, it contains the fruit of Fructus Lycopersici esculenti and stem and leaf as active component.
2. the compositions with lung heat clearing function is characterized in that, it contains the water of the fruit of Fructus Lycopersici esculenti and stem and leaf and/or alcohol extract as active component.
3. compositions according to claim 1 and 2 is characterized in that, described compositions is to make the form of beverage, food or medicine.
4. compositions according to claim 3 is characterized in that, described compositions is to make the form of oral liquid.
5. according to above-mentioned any described compositions of claim, it is characterized in that described compositions also contains flavoring agent.
6. according to above-mentioned any described compositions of claim, it is characterized in that described alcohol is ethanol.
7. preparation of compositions method with lung heat clearing function, it may further comprise the steps:
(1) chooses free of contamination Fructus Lycopersici esculenti as raw material, gather mellow fruit and stem and leaf;
(2) clean fruit, add suitable quantity of water and/or alcohol and carry out steaming and decocting, collect solution, make fruit extracting solution;
(3) clean stem and leaf, add suitable quantity of water and/or alcohol and carry out steaming and decocting, collect solution, make the stem and leaf extracting solution;
(4) fruit extracting solution with step (2) mixes with the stem and leaf extracting solution of step (3), makes mixed extract;
(5) mixed extract of step (4) is added in the acceptable suitable carrier of human body make compositions.
8. preparation of compositions method according to claim 7 is characterized in that, the alcohol described in step (2) and the step (3) is ethanol.
9. according to claim 7 or 8 described preparation of compositions methods, it is characterized in that the steaming and decocting described in the step (2) is at 80-100 ℃ of steaming and decocting 5-20 minute, the steaming and decocting described in the step (3) is at 80-120 ℃ of steaming and decocting 10-30 minute.
10. according to any described preparation of compositions method among the claim 7-9, it is characterized in that, the weight ratio of the water described in the step (2) and/or alcohol and described fruit is 1-3: 1, and the weight ratio of the water described in the step (3) and/or alcohol and described stem and leaf is 2-4: 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200410000254XA CN1234387C (en) | 2004-01-12 | 2004-01-12 | Composition possessing lung clearing function and its preparation metod |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200410000254XA CN1234387C (en) | 2004-01-12 | 2004-01-12 | Composition possessing lung clearing function and its preparation metod |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1555851A CN1555851A (en) | 2004-12-22 |
| CN1234387C true CN1234387C (en) | 2006-01-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200410000254XA Expired - Lifetime CN1234387C (en) | 2004-01-12 | 2004-01-12 | Composition possessing lung clearing function and its preparation metod |
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| Country | Link |
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| CN (1) | CN1234387C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167880B (en) * | 2007-11-20 | 2011-02-02 | 李迺灿 | Lung-clearing composition containing tomato fruit extraction and preparation method thereof |
| CN101167881B (en) * | 2007-11-20 | 2011-02-02 | 李迺灿 | Lung-clearing composition containing tomato plant stem extraction and preparation method thereof |
| GB0819959D0 (en) * | 2008-10-31 | 2008-12-10 | Provexis Natural Products Ltd | Fruit extracts |
| KR20110051876A (en) * | 2009-11-11 | 2011-05-18 | 남종현 | Composition having a detoxification effect on smoking |
| KR101092197B1 (en) | 2009-11-11 | 2011-12-13 | 남종현 | Food composition for improving fatty liver which comprises extract of tomato plant as an active component |
| CN102696714A (en) * | 2012-05-08 | 2012-10-03 | 王桂琴 | Nutritional flour and preparation method thereof |
| CN115316621A (en) * | 2022-07-12 | 2022-11-11 | 无限极（中国）有限公司 | Tomato composition and preparation method and application thereof |
-
2004
- 2004-01-12 CN CNB200410000254XA patent/CN1234387C/en not_active Expired - Lifetime
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|---|---|
| CN1555851A (en) | 2004-12-22 |
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