CN109663018A - It is a kind of for treating the Chinese medicinal granule and preparation method of silicosis - Google Patents

It is a kind of for treating the Chinese medicinal granule and preparation method of silicosis Download PDF

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CN109663018A
CN109663018A CN201910113782.2A CN201910113782A CN109663018A CN 109663018 A CN109663018 A CN 109663018A CN 201910113782 A CN201910113782 A CN 201910113782A CN 109663018 A CN109663018 A CN 109663018A
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chinese medicinal
silicosis
medicinal granule
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平措绕吉
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Abstract

The object of the present invention is to provide a kind of for treating the Chinese medicinal granule and preparation method of silicosis, is made by the raw material of following parts by weight: 7 ~ 20 parts of Fructus Lanceae tibeticae, alkali spend 10 ~ 32 parts, 38 ~ 65 parts of fructus piperis longi, 3 ~ 15 parts of Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, 15 ~ 38 parts of A Zhong, 30 ~ 70 parts of Radix Glycyrrhizae, 10 ~ 32 parts of natural salt and 32 ~ 80 parts of pharmaceutic adjuvant；The Chinese medicinal granule destroys organization structure of the plant through acetic acid boiling by Chinese medicine, it can promote the dissolution of active ingredients from traditional Chinese medicinal, then be extracted with alcohol reflux twice, so that the yield of effective component extracting is higher, it is finally prepared into Chinese medicinal granule, mouthfeel is slightly sweet, takes conducive to patient；The Chinese medicinal granule can be used for cough and asthma caused by treating silicosis endlessly, palpitation uncomfortable in chest, can clearing lung and eliminating phlegm, exclude lung's toxin.

Description

It is a kind of for treating the Chinese medicinal granule and preparation method of silicosis
Technical field
It is the invention belongs to the field of Chinese medicines, in particular to a kind of for treating the Chinese medicinal granule and preparation method of silicosis, it relates to And field of traditional Chinese medicine preparation, Chinese medicinal granule prepared by this method, can be used for cough and asthma caused by treating silicosis endlessly, palpitation uncomfortable in chest.
Background technique
Silicosis is due to sucking industrial dust for a long time, and with lung tissue Diffuse fibrous caused by the intrapulmonary retention Turn to main systemic disease.Silicosis is the occupational disease of most serious in the world.According to national health and Family Planning Committee Occupational disease ad hoc survey data show that silicosis and miner's pneumoconiosis are most commonly seen silicosis, and account for silicosis sum 90% is left The right side is in first of occupational disease.
Silicotic's early stage, with the development of disease condition, patient showed as cough, expectoration, gas more mostly without significant symptom It is short, the different Respiratory symptoms such as discomfort uncomfortable in chest.With the exacerbation of the state of an illness, silicosis may occur in which different complication, common Complication has pulmonary tuberculosis, respiratory tract infection, respiratory insufficiency, cor pulmonale and pneumothorax or even lung's occupy-place etc..I phase How asymptomatic silicotic's early stage is or symptoms are mild, and the appearance of II, III phase silicotic's symptom is early, more and heavier, and symptom is more Obvious for paroxysmal cough from morning, early stage mostly may occur in which purulence without sputum or a little white slimy phlegm or the thin phlegm of grey, later period Viscous phlegm, and it is sticky be not easy expectoration, cough symptom slightly mitigates after productive cough goes out, and coughs up sputum with blood streaks.
Silicosis can not also be eradicated at present by the method for drug therapy, and the emphasis for the treatment of and prevention is mostly to improve patient's Survival state, for the purpose of improving the quality of living.How to treat silicosis is the emphasis paid close attention to always both at home and abroad, and foreign countries are about silicosis Disease research is mainly mechanism of drug action research, and China has then carried out large-scale sample examination in terms of the treatment for studying this disease It tests.Wherein treatment method has drug therapy, nutrition treatment and operative treatment.Drug therapy has polyvinypyridine oxide drug therapy, current Drug therapy primarily serves the effect for alleviating symptom, not can effectively clear lung's dust；Nutrition treatment for nutrition is replenished in time, Passive protective physical fitness and the appropriate supply for increasing microelement are improved, to have to silicotic itself to the adjusting of symptom important Effect；There are also being exactly operative treatment, method has Whole lung lavage, and lung lavage technology can effectively remove lung's dust, still There are the problems such as more than at high cost, patient suffering and complication；It can also be selected when middle and advanced stage patient medication is bad It selects and transplant of lung is taken to be treated, the successful effect of lung transplantation is best, but there is operation cost and death rate height, donor hardly possible The problems such as looking for.
Tibetan medicine be Tibetan medicine's ancient Chinese medicine doctor clinical practice experience crystallization, have dosage is small, drug is pure natural, curative effect is high, The advantages that simplicity, Small side effects, suitable for the Pneumoconiosis Patients for needing Long-term taking medicine to treat.Medication is treated with instruction of Chinese Medicine theory pneumoconiosis, To ethno-medicine is carried forward, mitigate burden of patients, enhancing therapeutic effect has great significance.Silicosis is controlled in discovery in clinical treatment Therapeutic effect is significant, has the function of that other drugs are incomparable.To life in patients is improved, the deep hardship tormented by slight illness is saved Difficult family can also bring huge economic benefit and social benefit, have broad application prospects, be worth further research and Clinical expansion.
Therefore, the applicant according to the state of an illness feature of Silicosis Patients and the clinical experience of many years, select Tibetan medicine Fructus Lanceae tibeticae, Alkali flower, fructus piperis longi, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, A Zhong, Radix Glycyrrhizae, natural salt combination, for treat cough and asthma caused by silicosis endlessly, palpitation uncomfortable in chest, It can clearing lung and eliminating phlegm, exclusion lung's toxin.The present invention on the basis of traditional Tibetan medicine, by Tibetan medicine be formulated described in Chinese medicine, first The organization structure of the plant such as lignin, cellulose, the hemicellulose outside Chinese medicine are destroyed with acetic acid boiling, promote Chinese medicine effective The dissolution of ingredient, then extracted twice with alcohol reflux, so that the yield of effective component extracting is higher, finally it is prepared into Chinese medicine Particle, mouthfeel is slightly sweet, takes conducive to patient.
Summary of the invention
It is a kind of for treating the Chinese medicinal granule and preparation method of silicosis, which is characterized in that its by following parts by weight original Material is made: 7 ~ 20 parts of Fructus Lanceae tibeticae, alkali spend 10 ~ 32 parts, 38 ~ 65 parts of fructus piperis longi, 3 ~ 15 parts of Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, 15 ~ 38 parts of A Zhong, Radix Glycyrrhizae 30 ~ 70 parts, 10 ~ 32 parts of natural salt and 32 ~ 80 parts of pharmaceutic adjuvant.
Further, the pharmaceutic adjuvant, it is characterised in that auxiliary material include 5 ~ 25 parts of carboxymethyl cellulose, talcum powder 1 ~ 4 parts, 8 ~ 20 parts of pregelatinized starch, 4 ~ 15 parts of lactose.
Further, described a kind of for treating the preparation method of the Chinese medicinal granule of silicosis, feature includes following several A step:
(1) by the Fructus Lanceae tibeticae of recipe quantity, alkali flower, fructus piperis longi, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, A Zhong, milled 20 ~ 80 mesh of Radix Glycyrrhizae, 80 DEG C ~ 0.5 ~ 2h of boiling is carried out with 40 ~ 80 parts of acetic acid at 110 DEG C, is filtered；
(2) filter residue for obtaining step (1), twice with 40 ~ 100 part of 60% ethyl alcohol heating and refluxing extraction, 4 hours every time, filtration, The natural salt of recipe quantity is added in merging filtrate, recycles ethyl alcohol, and being concentrated into density is 1.2 ~ 1.4g/cm3；
(3) in the concentrate that step (2) obtains, the auxiliary material of recipe quantity is added, after being sufficiently mixed, using quick stirring technique into Row granulation.
Further, described a kind of for treating the Chinese medicinal granule and preparation method of silicosis, which is characterized in that in described Medicine particle application method is to brew use.
Further, described a kind of for treating the Chinese medicinal granule and preparation method of silicosis, which is characterized in that in described Medicine particle can be used for cough and asthma caused by treating silicosis endlessly, palpitation uncomfortable in chest, can clearing lung and eliminating phlegm, exclude lung's toxin.
The Chinese medicine being related in the present invention program is described as follows:
A Zhong: it is sweet in flavor, bitter, puckery, it is cool in nature.It brings down a fever, cough-relieving, blood pressure lowering, heat-clearing.Sharp lung, nourishing, controls pneumonia, bronchitis, high blood Pressure, scrofula, stranguria syndrome, epicoeloma empyema, the expectoration of phlegm difficulty, hysteropathy, " the appropriate book on Chinese herbal medicine of space " are recorded: " itself effect controls tuberculosis ". The Four-Volume Medical Code is recorded: " A Zhong treats lung heat syndrome ".
Radix Glycyrrhizae: it is sweet in flavor, it is sweet in flavor after digestion, it is cool in nature, it is soft, it puts down.Clearing and antitussive, eliminating the phlegm are quenched one's thirst, and lung is cured mainly
Disease, tracheitis, arteries and veins disease, vomiting etc..
The careless roots of grass: acrid flavour, bitter after digestion is warm-natured, rough and sharp.Warming spleen and stomach for dispelling cold, lower gas help digestion, and cure mainly cold grand disease, Baconic The various sympotoms caused by cold factors such as the cold, impotence of disease, stomach cold, kidney.
Natural salt: taste is salty, warm-natured, nontoxic.Clearing heat and cooling blood, the carbuncle that disappears block, help digestion brokenly product, promotes stomach sun, improves a poor appetite.Treatment Ring that stomach is swollen, be hard and dry, Pei Long and disease, eye disease, cold ruffian tumor.
Alkali flower: it is sweet in flavor, salty, it is warm-natured.It is aid digestion, drop.Treat peptic digest disease, especially digestion zanba, roasted qingke barley flour, Baconic's gastral cavilty be jammed, All worm diseases, worm poison mutually attack, rotten ulcer, constipation, all diseases of dropping.
Fructus Lanceae tibeticae: it is bitter, pungent, it is warm-natured.Cure mainly cough, pulmonary abscess, lung heat, neurasthenia, amnesia, palpitaition, insomnia." brilliant pearl Book on Chinese herbal medicine " it records: " flesh fruit grass roots supports lung, and support draws lung purulence, especially fruit and controls blood tumor, and easypro intestines tangle, and it is outstanding to break women's purplish or white patches on the skin lump in the abdomen curative effect It is good "." illustrated handbook " is recorded: " overlapping of flesh fruit blade of grass, is layered on ground, and Hua Lan prays for red, seed shape such as animal hearts, becomes red after mature Purple.Sweet in flavor, slight bitter controls all sores；It is described as long-living sweet dew, fruit controls heart disease；Ye Zhizhu sore, surpasses sweet dew；Root supports lung, and support is drawn Lung purulence ".
Detailed description of the invention
Fig. 1 is the pretherapy and post-treatment chest CT figure of Zeng.
Embodiment 1
(1) 10 parts of the Fructus Lanceae tibeticae of recipe quantity, alkali are spent into 10 parts, 39 parts of fructus piperis longi, 7 parts of Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, 21 parts of A Zhong, 30 parts of Radix Glycyrrhizae mills Broken 20 mesh of mistake, carries out boiling 0.5h with 40 parts of acetic acid at 80 DEG C, filtering；
(2) filter residue for obtaining step (1) twice with 60 part of 60% ethyl alcohol heating and refluxing extraction 4 hours every time, filters, merges 21 parts of natural salt of recipe quantity are added in filtrate, recycle ethyl alcohol, and being concentrated into density is 1.2g/cm3；
(3) 52 parts of auxiliary material of recipe quantity are added in the concentrate that step (2) obtains, auxiliary material by 8 parts of carboxymethyl cellulose, 3 parts of talcum powder, 18 parts of pregelatinized starch, 15 parts of lactose compositions, after being sufficiently mixed, are pelletized using quick stirring technique.
Embodiment 2
(1) 7 parts of the Fructus Lanceae tibeticae of recipe quantity, alkali are spent into 20 parts, 43 parts of fructus piperis longi, 9 parts of Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, 15 parts of A Zhong, 58 parts of Radix Glycyrrhizae mills Broken 40 mesh of mistake, carries out boiling 1h with 60 parts of acetic acid at 100 DEG C, filtering；
(2) filter residue for obtaining step (1) twice with 80 part of 60% ethyl alcohol heating and refluxing extraction 4 hours every time, filters, merges 25 parts of natural salt of recipe quantity are added in filtrate, recycle ethyl alcohol, and being concentrated into density is 1.4g/cm3；
(3) 43 parts of auxiliary material of recipe quantity are added in the concentrate that step (2) obtains, auxiliary material by 25 parts of carboxymethyl cellulose, 1 part of talcum powder, 20 parts of pregelatinized starch, 4 parts of lactose, after being sufficiently mixed, are pelletized using quick stirring technique.
Embodiment 3
(1) 19 parts of the Fructus Lanceae tibeticae of recipe quantity, alkali are spent into 32 parts, 65 parts of fructus piperis longi, 15 parts of Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, 15 parts of A Zhong, 47 parts of Radix Glycyrrhizae Milled 80 mesh carries out boiling 1h with 80 parts of acetic acid at 110 DEG C, filtering；
(2) filter residue for obtaining step (1), with 40 parts with 60% ethyl alcohol heating and refluxing extraction twice, 4 hours every time, filter, close And filtrate, 32 parts of natural salt of recipe quantity are added, recycle ethyl alcohol, being concentrated into density is 1.3g/cm3；
(3) 32 parts of auxiliary material of recipe quantity are added in the concentrate that step (2) obtains, auxiliary material by 20 parts of carboxymethyl cellulose, 2 parts of talcum powder, 8 parts of pregelatinized starch, 10 parts of lactose, after being sufficiently mixed, are pelletized using quick stirring technique.
Embodiment 4
(1) 20 parts of the Fructus Lanceae tibeticae of recipe quantity, alkali are spent into 15 parts, 43 parts of fructus piperis longi, 3 parts of Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, 38 parts of A Zhong, 70 parts of Radix Glycyrrhizae mills Broken 80 mesh of mistake, carries out boiling 1h with 60 parts of acetic acid at 100 DEG C, filtering；
(2) filter residue for obtaining step (1) twice with 100 part of 60% ethyl alcohol heating and refluxing extraction 4 hours every time, filters, merges 10 parts of natural salt of recipe quantity are added in filtrate, recycle ethyl alcohol, and being concentrated into density is 1.2g/cm3；
(3) 80 parts of auxiliary material of recipe quantity are added in the concentrate that step (2) obtains, auxiliary material by 15 parts of carboxymethyl cellulose, 4 parts of talcum powder, 20 parts of pregelatinized starch, 5 parts of lactose, after being sufficiently mixed, are pelletized using quick stirring technique.
Comparative example 1
(1) 20 parts of Fructus Lanceae tibeticae, the alkali of recipe quantity the boiling of Chinese medicine: are spent into 15 parts, 43 parts of fructus piperis longi, 3 parts of Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, A Zhong 38 Part, 70 parts of Radix Glycyrrhizae milled 80 meshes, carry out boiling 1h with 60 parts of water at 100 DEG C, filter；
(2) filter residue for obtaining step (1) twice with 100 part of 60% ethyl alcohol heating and refluxing extraction 4 hours every time, filters, merges 10 parts of natural salt of recipe quantity are added in filtrate, recycle ethyl alcohol, and being concentrated into density is 1.2g/cm3；
(3) 80 parts of auxiliary material of recipe quantity are added in the concentrate that step (2) obtains, auxiliary material by 15 parts of carboxymethyl cellulose, 4 parts of talcum powder, 20 parts of pregelatinized starch, 5 parts of lactose, after being sufficiently mixed, are pelletized using quick stirring technique.
Comparative example 2
(1) 20 parts of the Fructus Lanceae tibeticae of recipe quantity, alkali are spent into 15 parts, 43 parts of fructus piperis longi, 3 parts of Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, 38 parts of A Zhong, 70 parts of Radix Glycyrrhizae mills Broken 80 mesh of mistake, carries out boiling 1h with 60 parts of acetic acid at 100 DEG C, filtering；
(2) filter residue for obtaining step (1), it is primary with 100 part of 60% ethyl alcohol heating and refluxing extraction, it 4 hours every time, filters, merges 10 parts of natural salt of recipe quantity are added in filtrate, recycle ethyl alcohol, and being concentrated into density is 1.2g/cm3；
(3) 80 parts of auxiliary material of recipe quantity are added in the concentrate that step (2) obtains, auxiliary material by 15 parts of carboxymethyl cellulose, 4 parts of talcum powder, 20 parts of pregelatinized starch, 5 parts of lactose, after being sufficiently mixed, are pelletized using quick stirring technique.
Comparative example 3
(1) alkali of recipe quantity is spent into 15 parts, 43 parts of fructus piperis longi, 3 parts of Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, 38 parts of A Zhong, 70 parts of Radix Glycyrrhizae milled 80 meshes, Boiling 1h is carried out with 60 parts of acetic acid at 100 DEG C, is filtered；
(2) filter residue for obtaining step (1) twice with 100 part of 60% ethyl alcohol heating and refluxing extraction 4 hours every time, filters, merges 10 parts of natural salt of recipe quantity are added in filtrate, recycle ethyl alcohol, and being concentrated into density is 1.2g/cm3；
(3) 80 parts of auxiliary material of recipe quantity are added in the concentrate that step (2) obtains, auxiliary material by 15 parts of carboxymethyl cellulose, 4 parts of talcum powder, 20 parts of pregelatinized starch, 5 parts of lactose, after being sufficiently mixed, are pelletized using quick stirring technique.
Comparative example 4
(1) 20 parts of the Fructus Lanceae tibeticae of recipe quantity, alkali are spent into 15 parts, 43 parts of fructus piperis longi, 38 parts of A Zhong, 70 parts of Radix Glycyrrhizae milled 80 meshes, Boiling 1h is carried out with 60 parts of acetic acid at 100 DEG C, is filtered；
(2) filter residue for obtaining step (1) twice with 100 part of 60% ethyl alcohol heating and refluxing extraction 4 hours every time, filters, merges 10 parts of natural salt of recipe quantity are added in filtrate, recycle ethyl alcohol, and being concentrated into density is 1.2g/cm3；
(3) 80 parts of auxiliary material of recipe quantity are added in the concentrate that step (2) obtains, auxiliary material by 15 parts of carboxymethyl cellulose, 4 parts of talcum powder, 20 parts of pregelatinized starch, 5 parts of lactose, after being sufficiently mixed, are pelletized using quick stirring technique.
EXPERIMENTAL EXAMPLE 1: the Nature comparison of Chinese medicinal granule
It takes above-mentioned EXPERIMENTAL EXAMPLE 1 ~ 4 and compares example 1,2 made Chinese medicinal granules, carry out paste-forming rate, melting, mouthfeel and investigate.It takes Chinese medicinal granule 10g heats water 200ml, stirs 5 minutes, observes immediately, its taste is tasted in solution colour, particle melting parallel port, examines It is as follows to examine result:
The Nature comparison of 1 Chinese medicinal granule of table
It is above-mentioned the results showed that compared by embodiment 1 ~ 4 and comparative example 1 it is found that Chinese medicine without acetic acid boiling prepare in Medicine particle, solution colour is shallower, and paste-forming rate is minimum, i.e. active ingredients from traditional Chinese medicinal content is low, illustrates that Chinese medicine is broken through acetic acid boiling After bad plant tissue, the dissolution of active ingredients from traditional Chinese medicinal can be promoted；Experiment, boiling are relatively known by embodiment 1 ~ 4 and comparative example 2 Chinese medicine extracted once and twice with ethyl alcohol, solution colour and paste-forming rate are there are gap, and Chinese medicine extracts twice through ethyl alcohol, energy Improve the content of effective component.
EXPERIMENTAL EXAMPLE 2: animal pharmacology toxicological experiment
The made Chinese medicinal granule of above-mentioned EXPERIMENTAL EXAMPLE 1 ~ 4 is taken, the experiment of animal successive administration is carried out, takes the identical healthy mice of weight Every group of totally 40 half male and half females, totally 5 groups, wherein 1 ~ 4 group is fed Chinese medicinal granule respectively, the 4th group is set as the food that blank group feeds equivalent Object, at once to mouse systemic reaction and death condition in 14 days, including mouse weight variation, skin, hair, eye after observation administration Change, diet, breathing, behavior, appearance, excreta, secretion, toxic reaction and the death condition of eyeball and mucous membrane, wherein being poisoned The observation item of reaction include: poisoning symptom, serious degree, beginning and duration, whether within the observation period restore etc., To will be dead or oneself is through dead mouse should rapidly carry out gross anatomy in time, dead mouse exist within the observation period 14 Tian Hou collectives carry out gross anatomy, to being abnormal the organ (occur color, quality, volume etc. change) of change into jin tissue Pathological examination.It weighs when being administered the 3rd, 7,10 day and 14 days primary.The 14th day execution animal is administered, dissects, naked eyes are seen Examine main organs.
As a result: in experimentation, blank group and experimental group none dead mouse enter interpretation of result.Experimentation In, all mouse, skin smooth, no red and swollen, spot；Hair is moist；Ocular mucosae is wet；Breathing rule；Diet is normally carried out； It weighs and blank group no significant difference when the 3rd, 7,10 day and 14 days are administered；Mouse is without the abnormal behaviours such as twitch, tremble；Secretion Object, excreta are without exception；Without toxic reaction；Mouse is dissected after 14 days, organ is visible by naked eyes lesion.
Experiment embodiment 3: animal model test
Silicosis mouse model prepares: taking 60 ICR mouse half male and half female anesthesia to fix, vertically cutting off length in skin of neck is The opening of 5mm or so, exposure tracheae.Then tracheae is inserted into syringe needle direct oral cavity, it is ensured that after filling lung needle insertion tracheae, give Silica suspension 200ul is randomly divided into three groups after raising 14 days.
Administration experiment: Chinese medicinal granule prepared by Example 2, comparative example 3,4 the methods starts to be administered respectively, and one day 3 Secondary, the 0th day, 7 days, 14 days are being administered respectively in one time 1 packet (about 10g), and every group takes 6 mouse, after etherization, eye at random Vein takes the lobe of the lung to fix with 10% formalin from sacrificed by exsanguination after ball, prepares paraffin section, carries out HE and Masson dyeing, light Microscopic observation lung tissue changes.
The results showed that mouse is when starting administration the 0th day, alveolar wall and bronchial wall have fibrous thickening, with The destruction of alveolar structure, has silicotic nodule to be formed；When being administered the 7th day, 2 groups of alveolar septums of embodiment reduce, fibroblast, capillary Blood vessel is reduced；Silicotic nodule weakens, no dead mouse；When embodiment 2 is administered the 14th day, alveolar septum is obviously reduced, at fiber Cell, capillary significantly reduce, and silicotic nodule obviously becomes smaller, no dead mouse；3,4 groups of mouse of comparative example administration the 7th day, 14 days are to be obviously improved, when being administered the 14th day, 4 groups of the comparative example dead mouse of appearance 2.
Through animal experiments show that applicant selects Tibetan medicine according to the state of an illness feature of Silicosis Patients and the clinical experience of many years Fructus Lanceae tibeticae, alkali flower, fructus piperis longi, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, A Zhong, Radix Glycyrrhizae, natural salt combination, have certain therapeutic effect to silicosis.
EXPERIMENTAL EXAMPLE 4: clinical trial
The present inventor accepts a collection of 10 people of silicosis patient for medical treatment in July, 2018, and patient takes 2 institute of patent Example according to the present invention The Chinese medicinal granule for stating preparation is treated, and twice a day, one time one packet (about 10g) brews use with boiled water.Medication time: early Upper 09:30, noon 02:30,05:30 in afternoon；Duration of medication smoking ban alcohol prohibition, the exercise of Yao Shidu are such as strolled, play Tai Ji, are exhaled deeply Inhale etc., physical exertion a little in power is done, and inspect periodically every physical signs.
Experimental result: after patient takes medicine 10 days, 9 patient respiratory difficulties mitigate, and uncomfortable in chest, pectoralgia illness is obviously good Turn, cough is reduced, no phlegm；1 patient has difficulty in breathing once in a while, is uncomfortable in chest.After patient takes medicine 30 days, all patients, which walk, not to breathe heavily easily Gas, breathe it is not difficult, chest not bitterly, flu frequency reduction, diet, sleep, stool and urine it is normal.Continuous medication 3 months, all patients Cough, cough up phlegm, is uncomfortable in chest, wheezing, the symptoms were significantly improved or completely disappears for repeated cold etc., rabat image is obviously improved, completely extensive Demutation generates viability, and pulmonary function test firmly breathes lung capacity and firmly respiratory capacity raising 20% in one second, and 10 patients are through CT Inspection result is shown: the dust-nodule of 10 patients obviously dissipates, and reduces, and calcification, lung marking attenuates, and becomes clear.
The report of clinical test example case details:
Zeng, 58 years old, Hunan Province from Anhua County, main suit: more than 10 years of shortness of breath after repeated coughing, expectoration, activity.
Present illness history: 10 Yu Nianqian were once accredited as " two phase of silicosis " medical history in relevant departments, private prosecution Changes in weather suffer from cold and Easily there is dry cough repeatedly in autumn and winter, therefore asthma once repeatedly entered in hospital, and hereafter started shortness of breath after appearance activity, upper second floor I.e. sense is uncomfortable, and nearly half a month patient feels shortness of breath symptom and gradually aggravates.
Past medical history: being previously engaged in coal excacation, was once accredited as " two phase of silicosis " in relevant departments, deny " hepatitis, The infectious diseases medical history such as typhoid fever ", no history of operation, no blood transfusion history, no food hypersenstivity history.History of preventive inoculation is unknown, no Long-term taking medicine history.
Physiological status before treating: electrocardio diagram: normal sinus rhythm.Lung function is shown: slight obstructive pulmonary ventilatory function barrier Hinder；Diffusion is normal；Total lung capacity is normal, residual volume is normal, residual always than increasing, and airway resistance is normal.B ultrasound shows: liver parenchyma Echoenhance, luminous point thickening combine clinical.Chest CT is shown: silicosis (double lung silicosis blocks), and right side breast develops disease.
Physiological status after treatment: electrocardio diagram: normal sinus rhythm.Lung function is shown: normal.B ultrasound shows: liver parenchyma echo increases By force, luminous point thickening combines clinical.Chest CT is shown: in conjunction with occupational history, considering pneumoconiosis；Right side breast low-density stove, property are undetermined.
Treat conclusion: effectively；It improves after treatment than physical signs every before treatment, chest CT figure comparison result shows dirt Lung neoplasm obviously dissipates, and reduces, and calcification, lung marking attenuates, and becomes clear.

Claims (5)

1. a kind of for treating the Chinese medicinal granule and preparation method of silicosis, which is characterized in that its by following parts by weight raw material Be made: 7 ~ 20 parts of Fructus Lanceae tibeticae, alkali spend 10 ~ 32 parts, 38 ~ 65 parts of fructus piperis longi, 3 ~ 15 parts of Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, 15 ~ 38 parts of A Zhong, Radix Glycyrrhizae 30 ~ 70 parts, 10 ~ 32 parts of natural salt and 32 ~ 80 parts of pharmaceutic adjuvant.
2. pharmaceutic adjuvant according to claim 1, it is characterised in that auxiliary material is by 5 ~ 25 parts of carboxymethyl cellulose, talcum powder 1 ~ 4 part, 8 ~ 20 parts of pregelatinized starch, 4 ~ 15 parts of lactose compositions.
3. a kind of for treating the preparation method of the Chinese medicinal granule of silicosis described according to claim 1, feature includes such as Under several steps:
By the Fructus Lanceae tibeticae of recipe quantity, alkali flower, fructus piperis longi, Ligularia virgaurea (Maxim.) Mattf. Ex Rehd. Etkobuski, A Zhong, milled 20 ~ 80 mesh of Radix Glycyrrhizae, at 80 DEG C ~ 110 DEG C It is lower to carry out 0.5 ~ 2h of boiling with 40 ~ 80 parts of acetic acid, filtering;
The filter residue that step (1) is obtained twice with 40 ~ 100 part of 60% ethyl alcohol heating and refluxing extraction 4 hours every time, filters, merges The natural salt of recipe quantity is added in filtrate, recycles ethyl alcohol, and being concentrated into density is 1.2 ~ 1.4g/cm3;
In the concentrate that step (2) obtains, the auxiliary material of recipe quantity is added, after being sufficiently mixed, is carried out using quick stirring technique Granulation.
4. a kind of for treating the Chinese medicinal granule and preparation method of silicosis according to claim 1, which is characterized in that described Chinese medicinal granule application method is to brew use.
5. a kind of for treating the Chinese medicinal granule and preparation method of silicosis according to claim 1, which is characterized in that described Chinese medicinal granule can be used for cough and asthma caused by treating silicosis endlessly, palpitation uncomfortable in chest, can clearing lung and eliminating phlegm, exclude lung's toxin.
CN201910113782.2A 2019-02-14 2019-02-14 It is a kind of for treating the Chinese medicinal granule and preparation method of silicosis Pending CN109663018A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110384733A (en) * 2019-08-27 2019-10-29 洪雅县瓦屋山药业有限公司 A kind of refined even gelling agent and preparation method thereof
CN111991547A (en) * 2020-09-23 2020-11-27 浏阳利美医院有限公司 Tibetan medicine composition for treating pneumoconiosis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
左斌等: "矽肺大鼠肺组织肿瘤坏死因子-α和转化生长因子-β1的动态观察", 《深圳中西医结合杂志》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110384733A (en) * 2019-08-27 2019-10-29 洪雅县瓦屋山药业有限公司 A kind of refined even gelling agent and preparation method thereof
CN111991547A (en) * 2020-09-23 2020-11-27 浏阳利美医院有限公司 Tibetan medicine composition for treating pneumoconiosis and preparation method thereof

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Application publication date: 20190423