CN1234266A - Medicine for restoring islet cell to cure diabetes - Google Patents
Medicine for restoring islet cell to cure diabetes Download PDFInfo
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- CN1234266A CN1234266A CN 99107362 CN99107362A CN1234266A CN 1234266 A CN1234266 A CN 1234266A CN 99107362 CN99107362 CN 99107362 CN 99107362 A CN99107362 A CN 99107362A CN 1234266 A CN1234266 A CN 1234266A
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Abstract
The present invention relates to a Chinese medicine preparation for curing diabetes and its prescription and preparation method. It is characterized by that said Chiense medicine composite is formed from 22 Chinese medicinal materials of red ginseng, prepared flowery knotweed root, polygonatum root, astragalus root, schisandra berry, atractylodes root, ovate atractylodes root, litchee pit, ligusticum root and salvia root,etc.,and has no toxic side effect. The long-period taking said medicine can strengthen the function of human body, and is favourable for regenerating and repairing damaged islet cells, and promoting non-damaged islet cells to secrete more insulin so as to produce actions of reducing blood sugar and raising sugar tolerance, and possesses good effect for preventing and curing various complicating diseases resulted from diabetes.
Description
The present invention relates to a kind of Chinese herb medicine, particularly a kind of prescription and manufacture method that is used for the treatment of the Chinese medicine preparation medicine for restoring islet cell to cure diabetes of diabetes.
At present TCM treatment of diabetes got remarkable progress, make a general survey of each family to the many symptoms legislations of the research of primary disease with diabetes, its characteristics of tool are divided into the upper, middle and lower three types of diabetes.With the dryness of the lung, gastric heat, the dialectical opinion of making laws of suffering from a deficiency of the kidney controls, with qingfei yihuo, it is the basis of treatment diabetes that YIN nourishing is reinforced the kidney.Side's medicine is thrown in numerous and jumbled or single, and prescription is rigorous inadequately, and constance force does not reach disease, can not hit its key.In view of the above, the inventor maximizes favourable factors and minimizes unfavourable ones, and transports farmland legislation in many ways, with the deficiency of vital energy, the deficiency of YIN, the deficiency of both YIN and YANG blood circulation promoting and blood stasis dispelling of holding concurrently, is the basis of diabetes.Think that diabetes are multiple metabolism (sugar, fat, protein) imbalance, make laws, form medicine for restoring islet cell to cure diabetes side's medicine, for the treatment diabetes have been opened up new square medicine in conjunction with the research of science such as modern medicine genetics, immunology, insulin resistant.
Purpose of the present invention, be produce have double valency, efficient, nontoxic pair effect, can alleviate and cure the active drug of diabetes and complication thereof.
Main contents of the present invention and medicine are formed: by Radix Ginseng Rubra 20--40%, Radix Polygoni Multiflori Preparata 10--20%, Rhizoma Polygonati 20%, Radix Astragali 10--40%, Fructus Schisandrae Chinensis 5-40%, Rhizoma Atractylodis, each 10--20% of the Rhizoma Atractylodis Macrocephalae, Semen Litchi 10--30%, Rhizoma Chuanxiong, each 10--40% of Radix Salviae Miltiorrhizae, Rhizoma dioscoreae (parched) 20--50%, Fructus Corni 20--40%, Radix Rehmanniae 20--30%, Radix Bupleuri, Cortex Moutan, each 10--30% of Radix Puerariae, Pancreas Sus domestica dries, each 1--10% of carnitine, Semen Cassiae seed 10--20%, Colla Plastri Testudinis, each 10--20% of Fructus Cucurbitae moschatae powder, Radix Et Rhizoma Fagopyri Tatarici powder, Rhizoma amorphophalli powder is an amount of.
Method for making: remove Radix Et Rhizoma Fagopyri Tatarici powder, Rhizoma amorphophalli powder, Colla Plastri Testudinis, all the other medicines are pulverized with standby after the 120 mesh sieves sieve, in right amount Colla Plastri Testudinis are fried in shallow oil moltenly with water, again Radix Et Rhizoma Fagopyri Tatarici powder, Rhizoma amorphophalli powder are put into into scattered paste shape in right amount, whole medicated powder are not accompanied and a patent medicine group, be processed into the Semen phaseoli radiati size watered pill and get final product.
Pathology: diabetes spp traditional Chinese medical science diabetes category, analyze by its clinical arteries and veins disease, the diabetes deficiency of both QI and YIN is the important pathologic basis of primary disease, can directly or indirectly damage internal organs such as spleen, lung, kidney because of the diabetes Different types of etiopathogenises, makes dysfunction of the spleen in transportation, the smart compress seminal fluid that can not loose is precise and tiny; Deficiency of vital energy damage of essence and dryness-transformation, body fluid can not on hold in lung, so dryness of the lung body fluid deficiency drinking water to relieve thirst is the xerostomia polydipsia; The kidney usually involved in chronic disease, kidney are " the dominator of storing essence ", " be subjected to the vital organs of the human body and hide it ", the promise kidney is store essential substances not, and spleen is the lucid yang sending up not, just can cause under the vital essence and let out, the essence of water and grain material is used so do not go out from urine for human body, so muddiness and distinguish the flavor of sweetly insufficiency of the spleenly can not be stomach Xingqi body fluid, heat is given birth in the deficiency of stomach-Yin dryness-transformation, so kind flesh polyphagia is arranged, deficiency of spleen-QI, deficiency of the kidney yin then have the extremity asthenia, waist soreness is unable, becomes thin.Prolonged illness must the stasis of blood, deficiency of both QI and YIN, but with the passing of time the hyperamization arteries and veins stasis of blood stagnates, purplish tongue or ecchymosis is arranged.As seen the generation development of diabetes and lung, spleen, kidney are relevant, and therefore treating primary disease should be with air making-up and spleen enlivening enriching yin and nourishing kidney dissipating blood stasis, so that treating both the principal and the secondary aspects of a disease at the same time.
Prescription is analyzed: Radix Ginseng, Radix Astragali tonifying QI to produce body fluid.Data shows that Radix Ginseng has the effect of the diabetes rat of reduction fasting glucose, and has heart tonifying flesh and the active function of erythrocyte superoxide dismutase, improves immunity, regulates function.Be equipped with Rhizoma dioscoreae (parched), Rhizoma Atractylodis Macrocephalae (parched), the merit that Rhizoma Atractylodis strengthen invigorating the spleen and benefiting QI often has spleen the lucid yang sending up fortuneization, and Rhizoma Atractylodis also have tangible blood sugar reducing function.Rhizoma Polygonati, promotes the production of body fluid and moisturizes at Fructus Corni, the Radix Polygoni Multiflori, the invigorating the liver and kidney of Fructus Schisandrae Chinensis YIN nourishing, adds the smart marrow of mending, with the reinforcing both QI and YIN together of adding medicine to, to rescue the dryness of the lung, the Radix Polygoni Multiflori has the blood fat reducing effect, and Rhizoma Polygonati, Fructus Schisandrae Chinensis, Semen Litchi have the effect of blood sugar lowering, unpeeled CORTEX MOUTAN increases the liquid the kidney invigorating, the assistant Radix Rehmanniae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong clearing away heat and cooling blood dissipating blood stasis suppresses platelet viscous, promote the effective blood circulation of internal organs, prevent the generation of the heart, brain, kidney, retinopathy, Radix Bupleuri, Radix Puerariae heat clearing away and restlessness relieving are only quenched one's thirst.Radix Ginseng, the Radix Rehmanniae, Radix Bupleuri, Radix Puerariae can turn usefulness into by the non-enzyme sugar of Profilin matter machine, can effectively prevent protein reduction and aging, repair the pathological change of body tissue cell.The Pancreas Sus domestica body is dirty with dirty benefit, and carnitine is to participate in lipometabolic important substance, to diabetes, cardiopathic protection with treat significantly, is to promote myocardial metabolism, improves the medicine of cardiac function.The Fructus Cucurbitae moschatae powder QI invigorating is astringed the lung, and the effect of the multiple pancreas of blood sugar lowering is arranged.The Colla Plastri Testudinis nourishing YIN and benefiting blood, the Semen Cassiae blood fat reducing makes eye bright, and moisturizes nourishing, and Radix Et Rhizoma Fagopyri Tatarici contains dietary fiber, and the effect of rutin is arranged, and suppresses the vascular collagen saccharifying, reduces blood capillary fragility and permeability; Rhizoma amorphophalli powder reduces insulin resistant.All medicines share, and specimen gets mutually, and compatibility is harmonious, replenishing QI to invigorate the spleen, and YIN and YANG in a relative equilibrium, reinforcing both QI and YIN is regulated the vital organs of the human body, recovers islet cells, and lowering blood sugar and blood fat reaches the curative effect of curing diabetes.
The outstanding advantage of medicine for restoring islet cell to cure diabetes treatment diabetes is first-class pure Chinese medicinal preparation, and it makes simple, and taking convenience is beneficial to and carries.This medicine prescription is rigorous, and curative effect is outstanding, and emphasis is with enriching yin and nourishing kidney, the replenishing QI to invigorate the spleen aspects such as blood circulation promoting and blood stasis dispelling of holding concurrently, and according to the modern pharmacological research experiment, suppresses the medicine of platelet viscous effect with having blood sugar lowering, blood fat reducing, makes the pancreatic cell regeneration and the reparation of damage.Promote the islet cells that is not damaged to secrete more insulin, reach the effect of blood sugar lowering, with the also corresponding decline of the following blood fat reducing of blood glucose, can also improve anti-sugar amount, and the various complication that diabetes cause are had good preventing and therapeutical effect.
Case is selected: clarify a diagnosis according to The World Health Organization's diabetes diagnosis standard in 1985.
From year December in February to 1998 nineteen ninety, I accept diabetes cases 98 examples for medical treatment, male's 43 examples wherein, women's 55 examples.Age is in 34--66 year, average 48 years old, course of disease 1--14 annual 5 years, merge cardiovascular complication 8 examples, cerebrovascular complication 10 examples, retina complication 1 example, insulin independent form (NIDDM) 96 examples in 98 examples, insulin-dependent (IDDM) 2 examples are before this human therapy and use Western medicine glucose-lowering treatment, poor effect.
Press the medicine for restoring islet cell to cure diabetes therapist.Efficacy assessment standard is according to domestic and international interrelated data (Shandong College of Traditional Chinese Medicine's newspaper 1985; 9 (3): 7 tentative standards.
(1) produce effects: transference cure, fasting blood are reduced to normal or decline 2.8--4.8mmol/L, and glucose in urine is qualitative on an empty stomach turns out cloudy, and twenty-four-hour urine sugar is quantitatively reduced to below 5 grams.(2) effective: symptom obviously alleviates, more than the fasting glucose decline 1.68--2.80mmol/L, on an empty stomach the qualitative former positive person's plus sige of glucose in urine reduces 2, and twenty-four-hour urine sugar quantitatively drops to below 10 grams, or its absolute value of the critical person of the state of an illness descend before the treatment more than 50%.(3) invalid: symptom does not have improvement, and blood glucose, glucose in urine do not reach above standard person.
Therapeutic outcome: judge according to above-mentioned criterion of therapeutical effect, after the medicine for restoring islet cell to cure diabetes treatment, obtain produce effects 84 examples (86%) in 98 examples; Effective 11 examples (11%); Invalid 3 examples (3%); Total effective rate 97%.96 routine insulin independent forms, 95 examples obtain effect (99%): 2 routine insulin-dependents, obtain and imitate 1 example.
Lab index changes: 98 examples are after we's treatment, and fasting glucose descends and obtains produce effects 89 examples, effective 6 examples, and invalid 1 example, the blood sugar lowering total effective rate is 99%.Blood fat also obviously descends.See Table:
Fasting glucose (mmol/L) changes table before and after the treatment
Blood glucose level | The example number | Value before the treatment | Treatment back value | ----treatment back mean difference before the treatment |
Slightly | ????21 | ????8.34 | ?????6.2 | ????--2.14 |
Moderate | ????55 | ????12.27 | ?????8.1 | ????--4.17 |
Severe | ????22 | ????17.84 | ?????10.73 | ????--6.71 |
(P<0.001)
2, glucose in urine qualitative determination before the 98 example treatments has 3 examples negative, turning out cloudy property 68 examples after the treatment, and unlike signs reduces by two person's 23 examples.
54 examples of sampling are made glucose in urine quantitative assay treatment cross-reference table:
Meansigma methods before the treatment | Treatment back meansigma methods | Average reduction value |
37.83 gram/day | 9.66 gram/day | ----28.17 gram/days |
Treatment back glucose in urine significantly descend (P<0.001)
3, the variation of clinical symptoms: 98 routine diabeticss, after the oral medicine for restoring islet cell to cure diabetes treatment, original thirsty polydipsia; The frequent micturition muddiness, waist soreness, unable becoming thin, polyphagia or be off one's feed, uncomfortable 63 examples that wait transference cure of defecating, 31 examples that obviously alleviate do not have 4 examples of improving, and total effective rate reaches 95%, and other complication is also obviously improved, and effective percentage reaches about 79%.
4, late result observation: more than obtain and imitate all cases, the course of treatment of taking medicine is left and right sides drug withdrawal in a year, but requires diet control, the high sugar of few food, food rich in fat.Get final product, all follow up a case by regular visits to and do not see blood glucose knock-on in 3 years, fasting glucose is in normal range, glucose in urine feminine gender on an empty stomach, transference cure.6 routine patients are arranged, because of eating and drinking without temperance, recurrence such as drink.
Claims (1)
- The present invention relates to a kind of prescription and manufacture method for the treatment of the Chinese herb medicine of diabetes, it is characterized in that it is the medicament of being made by the following weight proportion raw material: Radix Ginseng Rubra 20--40%, Radix Polygoni Multiflori Preparata 10--20%, Rhizoma Polygonati 20%, Radix Astragali 10--40%, Fructus Schisandrae Chinensis 5--40%, Rhizoma Atractylodis, each 10--20% of the Rhizoma Atractylodis Macrocephalae, Semen Litchi 10--30%, Rhizoma Chuanxiong, each 10--40% of Radix Salviae Miltiorrhizae, Rhizoma dioscoreae (parched) 20--50%, Fructus Corni 20--40%, Radix Rehmanniae 20-30%, Radix Bupleuri, Cortex Moutan, each 10--30% of Radix Puerariae, Pancreas Sus domestica dries, each 1--10% of carnitine, Semen Cassiae seed 10--20%, Colla Plastri Testudinis, each 10--20% of Fructus Cucurbitae moschatae powder, Radix Et Rhizoma Fagopyri Tatarici powder, Rhizoma amorphophalli powder is an amount of.
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CN 99107362 CN1234266A (en) | 1999-05-18 | 1999-05-18 | Medicine for restoring islet cell to cure diabetes |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1296082C (en) * | 2004-12-09 | 2007-01-24 | 王宝民 | Medication and health food in use for lowering blood sugar, improving function of intestinal tract and reducing platelet aggergation |
CN1305404C (en) * | 2005-06-13 | 2007-03-21 | 郝文学 | Health caring foodstuff with antihypelipidemic and antihyperglycemic function and preparation method thereof |
WO2008138191A1 (en) * | 2007-05-10 | 2008-11-20 | Xiaoyong Zhang | A composition for treatment of diabetes mellitus and a preparation and an use thereof |
CN115363209A (en) * | 2022-07-07 | 2022-11-22 | 陈璞君 | Medicinal and edible food for conditioning diabetic syndromes |
-
1999
- 1999-05-18 CN CN 99107362 patent/CN1234266A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1296082C (en) * | 2004-12-09 | 2007-01-24 | 王宝民 | Medication and health food in use for lowering blood sugar, improving function of intestinal tract and reducing platelet aggergation |
CN1305404C (en) * | 2005-06-13 | 2007-03-21 | 郝文学 | Health caring foodstuff with antihypelipidemic and antihyperglycemic function and preparation method thereof |
WO2008138191A1 (en) * | 2007-05-10 | 2008-11-20 | Xiaoyong Zhang | A composition for treatment of diabetes mellitus and a preparation and an use thereof |
US8226990B2 (en) | 2007-05-10 | 2012-07-24 | Beijing Dfjx New Technology Co., Ltd. | Composition for treatment of diabetes mellitus and a preparation and an use thereof |
AU2007353284B2 (en) * | 2007-05-10 | 2013-01-10 | Beijing DFJX New Technology Co. Ltd. | A composition for treatment of diabetes mellitus and a preparation and an use thereof |
CN115363209A (en) * | 2022-07-07 | 2022-11-22 | 陈璞君 | Medicinal and edible food for conditioning diabetic syndromes |
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