CN1233407C - Mixture of aucklandia root and garden burnet for easing stomach and its preparation - Google Patents
Mixture of aucklandia root and garden burnet for easing stomach and its preparation Download PDFInfo
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- CN1233407C CN1233407C CN 200410021812 CN200410021812A CN1233407C CN 1233407 C CN1233407 C CN 1233407C CN 200410021812 CN200410021812 CN 200410021812 CN 200410021812 A CN200410021812 A CN 200410021812A CN 1233407 C CN1233407 C CN 1233407C
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Abstract
The present invention relates to a preparation of aucklandia root and garden burnet for easing stomach and a preparation method thereof. The preparation is prepared from garden burnet, aucklandia root, bletilla striata, etc., has the functions of reducing fever, easing stomachs, regulating air and alleviating pains and is used for diseases, such as gastric abscess, sour regurgitation, eructation, bitter taste, saburra, anorexia, food deficiency, etc. which are caused by cold and heat interwoven. Relevant tests for the present invention are carried out in Guizhou people hospital. Through the clinical verifidentification of 100 therapy groups and 40 control groups (Mistura Bismuthi Composta groups), the result verifies that the total effective rate of the therapy groups is 97 %, and the apparent rate is 64 %.
Description
Technical field: the present invention is a kind of mixture of aucklandia root and garden burnet for easing stomach and preparation method thereof, belongs to technical field of Chinese medicine.
Technical background: the gastralgia due to the coldheat complex, the acid regurgitation belch, bitter taste, halitosis, symptoms such as indigestion and loss of appetite lack of appetite are human body commonly encountered diseases, frequently-occurring disease, utilize Chinese medicine to treat to mainly contain the medicine or the medicine as Radix agastaches healthy energy preparation of invigorating the stomach and promoting digestion aspect in the prior art; These medicines have certain effect, but unobvious especially, particularly at different crowds, need select for use different medicines to treat, and can obtain reasonable effect.
Summary of the invention: the objective of the invention is to: a kind of mixture of aucklandia root and garden burnet for easing stomach and preparation method thereof is provided; Another object of the present invention has provided the preparation method of this Chinese medicine composition.
Medicament selection Radix Sanguisorbae of the present invention, the Radix Aucklandiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Imperatae, Rhizoma Atractylodis, cubeb are made preparation of the present invention, thereby make each efficacy of drugs produce synergism these drug regimens and can be effective to gastralgia due to the coldheat complex, the acid regurgitation belch, bitter taste, mouth is smelt the treatment of symptoms such as indigestion and loss of appetite lack of appetite.Wherein: with the Radix Aucklandiae, cubeb is a monarch drug in the side, and the Radix Aucklandiae is hot, bitter, warm.Return spleen, stomach, large intestine, gallbladder, tri-jiao channel, function is promoting the circulation of QI to relieve pain.Cubeb, hot, warm.Return spleen, stomach, kidney, urinary bladder channel.The function warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, invigorating the stomach and promoting digestion.The two compatibility can promoting the circulation of QI to relieve pain, again can warming spleen and stomach for dispelling cold, and promoting the circulation of QI to relieve pain, invigorating the stomach and promoting digestion.Main symptom to the gastral cavilty stomachache due to the stagnation of QI, food stagnation, cold-evil visitor stomach can embody the merit that cures mainly.Get Rhizoma Atractylodis in the side, Pseudobulbus Bletillae (Rhizoma Bletillae) is a ministerial drug.Rhizoma Atractylodis, suffering, hardship, temperature.Return spleen, stomach warp, function is drying damp and strengthening spleen.Semen Raphani, suffering, sweet, flat.Return spleen, stomach, lung meridian.Function helps digestion to remove and expands, pool gasification expectorant.This medicine can be drying damp and strengthening spleen, helps digestion to remove to expand the principal drug assistance relieving pain by regulating middle-JIAO of regulating the flow of vital energy.Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter, sweet, puckery.Return lung, stomach, Liver Channel.The function astringing to arrest bleeding, detumescence and promoting granulation.Pseudobulbus Bletillae (Rhizoma Bletillae), to prolonged illness damage stomach network so that bleeder, can the principal drug assistance astringing to arrest bleeding.Radix Sanguisorbae, Rhizoma Imperatae are adjuvant drug in the side, Radix Sanguisorbae, hardship, acid, are slightly cold.Return liver, stomach, large intestine channel.The function cooling blood for hemostasis.Rhizoma Imperatae, sweet, cold.Return lung, stomach, urinary bladder channel.The function cooling blood for hemostasis, this two be adjuvant drug altogether.The warm-dryness syndrome of the property of medicine in the system side can be helped, and the power of monarch, ministerial drug hemostasis can be assisted.Radix Glycyrrhizae, sweet flat.Return liver, spleen, stomach warp.The invigorating middle warmer of function QI invigorating, relieving spasm to stop pain, the mediation property of medicine is so be
Messenger drug.All medicines share, and play clearing heat to ease the stomach altogether, the function of regulating QI to relieve pain.Be applicable to because of the gastralgia due to the coldheat complex acid regurgitation belch, bitter taste, halitosis, indigestion and loss of appetite lack of appetite, the diseases such as tending to vomit of feeling sick.In order to reach better therapeutic, medicine of the present invention also makes up with Fructus Chaenomelis, Semen Raphani, Radix Glycyrrhizae.At this moment because Semen Raphani, suffering, sweet, flat.Return spleen, stomach, lung meridian.Function helps digestion to remove and expands, pool gasification expectorant.This medicine also can be drying damp and strengthening spleen, helps digestion remove to expand the principal drug assistance relieving pain by regulating middle-JIAO of regulating the flow of vital energy; Radix Glycyrrhizae, sweet flat.Return liver, spleen, stomach warp.The invigorating middle warmer of function QI invigorating, relieving spasm to stop pain, the mediation property of medicine is so be messenger drug; Fructus Chaenomelis can make the diabetes involving middle-JIAO food, strengthen the wriggling function of stomach.
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and the each component consumption that provides according to the inventor all has better curative effect.
The present invention constitutes like this: mixture of aucklandia root and garden burnet for easing stomach, it mainly is that medicine by the following weight component is made into: it is by Radix Sanguisorbae 80-120 part, Radix Aucklandiae 40-80 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-60 part, Rhizoma Imperatae 20-60 part, Rhizoma Atractylodis 20-40 part, cubeb 10-30 part.Proportioning is accurately: Radix Sanguisorbae 100g, Radix Aucklandiae 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40g, Rhizoma Imperatae 40g, Rhizoma Atractylodis 30g, cubeb 20g.Described mixture can also comprise: capsule, soft capsule, granule, pill, concentrated pill, drop pill, oral liquid, syrup, powder, mixture for the oral formulations of all medical science permissions.The preparation method of described mixture of aucklandia root and garden burnet for easing stomach is: it is standby to take by weighing each crude drug Radix Sanguisorbae, the Radix Aucklandiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Imperatae, Rhizoma Atractylodis, cubeb, Radix Sanguisorbae adds the ethanol heating of 7 times of amounts, reflux, extract,, filter, filtrate for later use, Rhizoma Atractylodis, Radix Aucklandiae extracting in water volatile oil, the aqueous solution behind the extraction volatile oil is standby; All the other medical materials and above-mentioned medicinal residues merge, decoct with water secondary, add for the first time the water that 10--7 doubly measures, decocted 2 to 1.5 hours, add for the second time the water that 7--5 doubly measures, decocted 1.5--1 hour, filter, merging filtrate adds Rhizoma Atractylodis, and relative density was 1.08--1.10 when the Radix Aucklandiae extracted aqueous solution behind the volatile oil and is concentrated into 60 ℃, adds ethanol and makes and contain the alcohol amount and be 55-75%, left standstill 24 hours, filtrate merges with the Radix Sanguisorbae extracting solution that obtains, and relative density is 1.10--1.13 when being concentrated into 60 ℃ behind the recovery ethanol, just has been prepared into the active component of medicine of the present invention.Also be added with Fructus Chaenomelis 20-40 part, Semen Raphani 20-40 part, Radix Glycyrrhizae 20-40 part among the present invention.Wherein the consumption of each component is: Radix Sanguisorbae 100g, Radix Aucklandiae 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40g, Rhizoma Imperatae 40g, Rhizoma Atractylodis 30g, cubeb 20g, Fructus Chaenomelis 30g, Semen Raphani 30g, Radix Glycyrrhizae 30g.Its preparation method is: Radix Sanguisorbae adds the 60% ethanol heating that 5-9 doubly measures, and reflux, extract, 2.5 hours filters filtrate for later use; Rhizoma Atractylodis, Radix Aucklandiae extracting in water volatile oil 3 hours, the aqueous solution behind the extraction volatile oil is standby; All the other medical materials decoct with water secondary with the medicinal residues that obtain, add for the first time the water that 10--7 doubly measures, decocted 2 to 1.5 hours, add for the second time the water that 7--5 doubly measures, decocted 1.5--1 hour, filter, merging filtrate adds Rhizoma Atractylodis, it is 1.08--1.10 60 ℃ of surveys that aqueous solution behind the Radix Aucklandiae extraction volatile oil is concentrated into relative density, add ethanol and make that to contain alcohol amount be 60%, left standstill 24 hours, filtrate and Radix Sanguisorbae extracting solution merge, and being concentrated into relative density behind the recovery ethanol is 1.10--1.13 60 ℃ of surveys, add suitable amount of sucrose, add again and use dissolved ethylparaben 1.5g of ethanol 30--50ml and volatile oil earlier, add water and make 1000ml, just be prepared into the oral liquid formulations that contains active component of the present invention.Among the present invention, with active component and the capsule mixed capsule that makes of adjuvant commonly used that makes.In the active component that makes, add sweeting agent commonly used, the mixed oral liquid that makes of sucrose; Adopt other conventional method can prepare different dosage forms.
Compared with prior art: the present invention has clearing heat to ease the stomach, the function of regulating QI to relieve pain.Be used for the gastralgia due to the coldheat complex, the acid regurgitation belch, bitter taste mouthful is smelt symptoms such as indigestion and loss of appetite lack of appetite; Mixture of aucklandia root and garden burnet for easing stomach major function provided by the invention be promoting the circulation of QI to relieve pain and in be good for the stomach, be used for gastralgia, the acid regurgitation belch, the bitter taste halitosis, indigestion and loss of appetite lack of appetite and acute or chronic gastritis, peptic ulcer, the present invention is made into behind the mixture and has carried out relevant test in the Guizhou Province People ' s Hospital, through clinical verification, 100 examples are organized in treatment, matched group (Mistura Bismuthi Composta group) 40 examples.The result confirms that treatment group total effective rate is 97%, and obvious effective rate is 64%.The matched group total effective rate is 90%, obvious effective rate 62.5%.Both do not have significant difference.The Mistura Bismuthi Composta that matched group uses belongs to the basic medicine of national Chinese medicine, can affirm fully the curative effect of mixture of aucklandia root and garden burnet for easing stomach thus.
Clinical data shows, two groups sex, age ratio, the treatment group age, (X ± SD) 42.09 ± 8.6, and the matched group age, (X ± SD) 41.60 ± 8.8.Learn by statistics and handle the difference nonsignificance.
From treating preceding two groups disease kind and tcm syndrome relatively, treatment group acute gastritis accounts for 30%, and chronic gastritis accounts for 40%, and peptic ulcer accounts for 30%, and group is respectively 30%, 30%, 40%.Treatment group syndrome of stagnation of QI accounts for 35% on TCM Syndrome Type, and the fixed card that coagulates accounts for 33%, and the food stagnation card accounts for 32%, compares with matched group, also no significant difference.
From main clinical pointer curative effect comparison mixture of aucklandia root and garden burnet for easing stomach to gastric abscess the clinical improvement of accusing of compared than evident difference than matched group, this shows that improving on patient's gastric abscess pointer of mixture of aucklandia root and garden burnet for easing stomach is more remarkable.
Can prove that thus the fragrant elm stomach mediating recipe that relaxes is the medicine that truly has curative effect at the treatment gastral cavilty aspect painful, and its taking convenience, safely, have no adverse reaction and toxic reaction.
Model case:
Example 1, old * *, man, 53 years old, nine innings of workers of water power, calendar year 2001 first visit on March 26.
The patient caused diarrhoea because of eating raw food before year, and the back diarrhoea of taking medicine takes a turn for the better, but does not adhere to treatment, sends out when later, and card is seen; Gastralgia, the acid regurgitation belch, the bitter taste halitosis, indigestion and loss of appetite lack of appetite, loose stool,
Spiritlessness and sparing of words, fatigue and asthenia, shallow complexion, pale tongue with white fur, thready and weak pulse is burnt in the cold and stagnate by this, insufficiency of the spleenly can not be good for fortune, gastric qi is unsuitable, when with promoting the circulation of QI to relieve pain and in be good for the stomach.Give clothes fragrant elm WEISHU JIAONANG preparation, every day 3 times, each 2, take medicine after 1 week, gastralgia subtracts greatly, and appetite increases, but it is rare half congealed that stool still has, gastric area feeling of repletion slightly after the food makes it continue to take mixture of aucklandia root and garden burnet for easing stomach, 2 week the back spiritlessness and weakness, the tired lazy speech phenomenon of body disappears, loose stool alleviates, and continues this medicine of clothes after 4 weeks, and all diseases disappear as ordinary person.
Example 2, Lee * *, the man, 21 years old, the time meet midsummer, hungry in the way because of swimming outward, and drenched with rain with the friend, come back and promptly feel the heavy sensation of the body fatigue and asthenia, stomach painful can, promptly my institute seeks medical advice, card is seen; The gastral cavilty tenderness, the tending to vomit of feeling sick, diarrhea, tastelessness and do not think drink, the tongue knot is red, middle root yellowish and greasy fur, rolling and rapid pulse is examined and is acute gastric abscess (coagulated cold syndrome), gives the clothes mixture of aucklandia root and garden burnet for easing stomach, and every day three times, each 30ml serve on for 3 weeks, and all diseases are known more rehabilitation.
Concrete embodiment:
Embodiments of the invention 1: take by weighing each crude drug Radix Sanguisorbae 100g, Radix Aucklandiae 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40g, Rhizoma Imperatae 40g, Rhizoma Atractylodis 30g, cubeb 20g are standby, Radix Sanguisorbae adds the ethanol heating of 7 times of amounts, reflux, extract,, filter, filtrate for later use, Rhizoma Atractylodis, Radix Aucklandiae extracting in water volatile oil, the aqueous solution behind the extraction volatile oil is standby; All the other medical materials and above-mentioned medicinal residues merge, decoct with water secondary, the water that adds for the first time 10 times of amounts, decocted 2 hours, the water that adds for the second time 7 times of amounts, decocted 1.5 hours, filter, merging filtrate adds Rhizoma Atractylodis, and relative density was 1.08--1.10 when the Radix Aucklandiae extracted aqueous solution behind the volatile oil and is concentrated into 60 ℃, adds ethanol and makes that to contain the alcohol amount be 55%, left standstill 24 hours, filtrate merges with the Radix Sanguisorbae extracting solution that obtains, and relative density is 1.10--1.13 when being concentrated into 60 ℃ behind the recovery ethanol, just has been prepared into the active component of medicine of the present invention.Can become the preparation that needs according to prior art production.Comprise: capsule, soft capsule, granule, pill, concentrated pill, drop pill, oral liquid, syrup, powder, mixture.
Embodiments of the invention 2: it is standby to take by weighing each crude drug Radix Sanguisorbae 80 grams, the Radix Aucklandiae 40 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 20 grams, Rhizoma Imperatae 20 grams, Rhizoma Atractylodis 20 grams, cubeb 10 grams, Radix Sanguisorbae adds the ethanol heating of 7 times of amounts, reflux, extract,, filter, filtrate for later use, Rhizoma Atractylodis, Radix Aucklandiae extracting in water volatile oil, the aqueous solution behind the extraction volatile oil is standby; All the other medical materials and above-mentioned medicinal residues merge, decoct with water secondary, the water that adds for the first time 7 times of amounts, decocted 1.5 hours, the water that adds for the second time 5 times of amounts, decocted 1 hour, filter, merging filtrate adds Rhizoma Atractylodis, and relative density was 1.08--1.10 when the Radix Aucklandiae extracted aqueous solution behind the volatile oil and is concentrated into 60 ℃, adds ethanol and makes that to contain the alcohol amount be 75%, left standstill 24 hours, filtrate merges with the Radix Sanguisorbae extracting solution that obtains, and relative density is 1.10--1.13 when being concentrated into 60 ℃ behind the recovery ethanol, just has been prepared into the active component of medicine of the present invention.
Embodiments of the invention 3: it is standby to take by weighing each crude drug Radix Sanguisorbae 120 grams, the Radix Aucklandiae 80 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 60 grams, Rhizoma Imperatae 60 grams, Rhizoma Atractylodis 40 grams, cubeb 30 grams, Radix Sanguisorbae adds the ethanol heating of 7 times of amounts, reflux, extract,, filter, filtrate for later use, Rhizoma Atractylodis, Radix Aucklandiae extracting in water volatile oil, the aqueous solution behind the extraction volatile oil is standby; All the other medical materials and above-mentioned medicinal residues merge, decoct with water secondary, the water that adds for the first time 8 times of amounts, decocted 2 hours, the water that adds for the second time 6 times of amounts, decocted 1 hour, filter, merging filtrate adds Rhizoma Atractylodis, and relative density was 1.08--1.10 when the Radix Aucklandiae extracted aqueous solution behind the volatile oil and is concentrated into 60 ℃, adds ethanol and makes that to contain the alcohol amount be 60%, left standstill 24 hours, filtrate merges with the Radix Sanguisorbae extracting solution that obtains, and relative density is 1.10--1.13 when being concentrated into 60 ℃ behind the recovery ethanol, just has been prepared into the active component of medicine of the present invention.
Embodiments of the invention 4: take by weighing Radix Sanguisorbae 100g, Radix Aucklandiae 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40g, Rhizoma Imperatae 40g, Rhizoma Atractylodis 30g, cubeb 20g, Fructus Chaenomelis 30g, Semen Raphani 30g, Radix Glycyrrhizae 30g.60% ethanol that Radix Sanguisorbae is added 7 times of amounts heats, and reflux, extract, 2.5 hours filters filtrate for later use; Rhizoma Atractylodis, Radix Aucklandiae extracting in water volatile oil 3 hours, the aqueous solution behind the extraction volatile oil is standby; All the other medical materials decoct with water secondary with the medicinal residues that obtain, the water that adds for the first time 8 times of amounts, decocted 2 hours, the water that adds for the second time 6 times of amounts, decocted 1.5 hours, filter, merging filtrate adds Rhizoma Atractylodis, and it is 1.08--1.10 60 ℃ of surveys that the aqueous solution behind the Radix Aucklandiae extraction volatile oil is concentrated into relative density, add ethanol and make that to contain alcohol amount be 60%, left standstill 24 hours, filtrate and Radix Sanguisorbae extracting solution merge, and being concentrated into relative density behind the recovery ethanol is 1.10--1.13 60 ℃ of surveys, add sucrose 60g, add again and use dissolved ethylparaben 1.5g of ethanol 40ml and volatile oil earlier, add water and make 1000ml, just be prepared into the oral liquid formulations that contains active component of the present invention.
Claims (8)
1, a kind of mixture of aucklandia root and garden burnet for easing stomach is characterized in that: calculate according to composition by weight: it is made with Radix Sanguisorbae 80-120 part, Radix Aucklandiae 40-80 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-60 part, Rhizoma Imperatae 20-60 part, Rhizoma Atractylodis 20-40 part and cubeb 10-30 part.
2, according to the described mixture of aucklandia root and garden burnet for easing stomach of claim 1, it is characterized in that: proportioning is accurately: Radix Sanguisorbae 100g, Radix Aucklandiae 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40g, Rhizoma Imperatae 40g, Rhizoma Atractylodis 30g, cubeb 20g.
3, according to the described mixture of aucklandia root and garden burnet for easing stomach of claim 1, it is characterized in that: described this mixture can also be: capsule, soft capsule, granule, pill, concentrated pill, drop pill, oral liquid, syrup, powder, mixture.
4, according to the preparation method of claim 1 or 2 described mixture of aucklandia root and garden burnet for easing stomach, it is characterized in that: it is standby to take by weighing each crude drug Radix Sanguisorbae, the Radix Aucklandiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Imperatae, Rhizoma Atractylodis, cubeb, Radix Sanguisorbae adds the ethanol heating of 7 times of amounts, reflux, extract,, filter, filtrate for later use, Rhizoma Atractylodis, Radix Aucklandiae extracting in water volatile oil, the aqueous solution behind the extraction volatile oil is standby; All the other medical materials and above-mentioned medicinal residues merge, decoct with water secondary, for the first time add 10---the water of 7 times of amounts, decocted 2 to 1.5 hours, for the second time add 7---the water of 5 times of amounts, decoct 1.5---1 hour, filter, merging filtrate adds Rhizoma Atractylodis, and relative density was 1.08 when the Radix Aucklandiae extracted aqueous solution behind the volatile oil and is concentrated into 60 ℃---and 1.10, add ethanol and make and contain the alcohol amount and be 55-75%, left standstill 24 hours, filtrate merges with the Radix Sanguisorbae extracting solution that obtains, reclaims that relative density is 1.10 when being concentrated into 60 ℃ behind the ethanol---and 1.13, just be prepared into the active component of medicine of the present invention.
5, according to the described mixture of aucklandia root and garden burnet for easing stomach of claim 1, it is characterized in that: also be added with Fructus Chaenomelis 20-40 part, Semen Raphani 20-40 part, Radix Glycyrrhizae 20-40 part.
6, according to the described mixture of aucklandia root and garden burnet for easing stomach of claim 5, it is characterized in that: wherein the consumption of each component is: Radix Sanguisorbae 100g, Radix Aucklandiae 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40g, Rhizoma Imperatae 40g, Rhizoma Atractylodis 30g, cubeb 20g, Fructus Chaenomelis 30g, Semen Raphani 30g, Radix Glycyrrhizae 30g.
7, according to the preparation method of claim 5 or 6 described mixture of aucklandia root and garden burnet for easing stomach, it is characterized in that: Radix Sanguisorbae adds the 60% ethanol heating that 5-9 doubly measures, and reflux, extract, 2.5 hours filters filtrate for later use; Rhizoma Atractylodis, Radix Aucklandiae extracting in water volatile oil 3 hours, the aqueous solution behind the extraction volatile oil is standby; All the other medical materials decoct with water secondary with the medicinal residues that obtain, for the first time add 10---the water of 7 times of amounts, decocted 2 to 1.5 hours, for the second time add 7---the water of 5 times of amounts, decoct 1.5---1 hour, filter, merging filtrate adds Rhizoma Atractylodis, it is 1.08 60 ℃ of surveys that aqueous solution behind the Radix Aucklandiae extraction volatile oil is concentrated into relative density---1.10, add ethanol and make that to contain alcohol amount be 60%, left standstill 24 hours, filtrate and Radix Sanguisorbae extracting solution merge, and being concentrated into relative density behind the recovery ethanol is 1.10 60 ℃ of surveys---and 1.13, add suitable amount of sucrose, add again and use ethanol 30---dissolved ethylparaben 1.5g of 50ml and volatile oil earlier, add water and make 1000ml, just be prepared into the oral liquid formulations that contains active component of the present invention.
8, according to the preparation method of the described mixture of aucklandia root and garden burnet for easing stomach of claim 7, it is characterized in that: wherein with the active component and the capsule mixed capsule that makes of adjuvant commonly used that make.
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