CN1226439A

CN1226439A - Composite medicinal injection for hemiparalysis

Info

Publication number: CN1226439A
Application number: CN 98122910
Authority: CN
Inventors: 李国荣
Original assignee: Individual
Current assignee: Individual
Priority date: 1998-11-20
Filing date: 1998-11-20
Publication date: 1999-08-25
Anticipated expiration: 2018-11-20
Also published as: CN1067586C

Abstract

A composite injection for treating hemiplegia, poliomyelitic sequela and myasthenia gravis with effective rate of 95-100% contains such components as VB1, VB6, VB12, red sage root injection, ligustrazine phosphate or hydrochloride, corenalin, physiological saline, etc. It serves to improve the functions of damaged nerve and vascular system, restore the movement function of limbs and atrophic muscle tissue and increase memory power.

Description

A kind of composite medicinal injection for the treatment of hemiplegia

The present invention relates to a kind of composite medicinal injection, particularly a kind of composite medicinal injection for the treatment of hemiplegia.

Annual nearly 263 people of China suffer from cerebral apoplexy. In the middle of 1,240,000 people from left and right sides of survival, 80% deformity that leaves is in various degree arranged approximately, need to treat (Wang Hongzhong, Xu Jianpeng chief editor " practical combination of Chinese tradiational and Western medicine hemiparalysis recovery is learned ", Chinese Medicine science and technology publishing house, in May, 1997, front page). At present medical circle has been carried out a large amount of research to the cause of disease, morbidity, diagnosis and the treatment of apoplexy, and makes great progress, but less to the research of paralytic's rehabilitation. According to clinical medical custom, as long as function stop such as hemiparalysis human motions, therapeutic process also just finishes. Be used for the treatment of at present hemiplegia mainly with kinesiatrics, acupuncture therapy, treatment by Chinese herbs (what wide new volume " stroke rehabilitation and acupuncture-moxibustion " that waits, China Traditional Chinese Medicine Publishing House, in November, 1997 front page). But existing methods for the treatment of all exists the course for the treatment of long, efficient low problem, and the patient is difficult to reach self care ability.

The purpose of this invention is to provide a kind of composite medicinal injection that can effectively treat hemiplegia.

Technical scheme of the present invention is as follows: Cobastab, the red sage root, ligustrazine, a leaf autumn alkali, citicoline are mixed with a kind of muscle or acupoint injection therapy liquid by a certain percentage. Its composition of medicine component content (by working concentration mg/100ml) is:

Cobastab₁ 400-800mg

Cobastab₆ 50-100mg

Cobastab₁₂ 5-10mg

Danshen injections (crude drug content) 3000-6000mg

Ligustrazine phosphat or Securinine hydrochloride 380-750mg

One leaf autumn of nitric acid alkali or Securinine hydrochloride 8-16mg

CDPC 500-1000mg

All the other are assigned to 100ml with 0.9% physiological saline.

Danshen injections in the such scheme can be with pure danshen injections, compound injection of red sage root or sodium tashinone II A sulfonate injection.

Composite medicinal injection of the present invention, owing to contain central nervous system in the prescription, particularly spinal cord has a leaf autumn alkali of appreciable stimulating action; CDPC in the prescription can promote lecithin synthetic, and excited reticular formation of brain stem recovers the nerve fiber function and improves the brain metabolism; The red sage root in the prescription, ligustrazine can improve brain microcirculation and brain blood flow, improve the ability of organizing anti-anoxic; And Cobastab same clan medicine can participate in various metabolic processes in the body, and is particularly evident to nerve and vascular system. The combination of above medicine can improve the function of injured nerve, vascular system, can recover quickly and effectively the autokinetic movement function of paralyzed limbs, atrophied musculature is restored in a short period of time, and can improves patient's memory and improve to greatest extent handicapped person's functional status and raising self care ability.

Adopt composite medicinal injection of the present invention, except being used for the treatment of hemiplegia, can also be used for the treatment of sequelae of infantile paralysis, myasthenia gravis, progressive muscular dystrophy. Use and efficiently in efficient 95%, three ten day in this parenteral solution ten days reach 100%.

Below in conjunction with embodiment and the treatment case the present invention is further illustrated.

The embodiment I

The preparation of this composite medicinal injection (pressing mg/100ml), with commercially available finished product parenteral solution, prescription:

Cobastab₁ 800mg

Cobastab₆ 100mg

Cobastab₁₂ 10mg

Compound Danshen Root (or sodium tanshinon Ⅱa silate) 3000mg

Ligustrazine phosphat (or Ligustrazine Hydrochloride) 750mg

Nitric acid one leaf autumn alkali (or Securinine hydrochloride) 16mg

Citicoline 10O0mg

All the other join 100ml with 0.9% physiological saline.

Be used for that elbow appears bending in hemiplegia, upper limbs, the wrist that hangs down, count on one's fingers etc., select 5 acupoint injection therapies at every turn, every cave 1ml, once a day. Be used for lower limb and drop foot, strephenopodia etc. occur, select 5 acupoint injection therapies at every turn, every cave 1ml, once a day.

The embodiment II

Cobastab₁ 600mg

Cobastab₆ 80mg

Cobastab₁₂ 8mg

Compound Danshen Root (or sodium tanshinon Ⅱa silate) 5000mg

Ligustrazine phosphat (or Ligustrazine Hydrochloride) 600mg

Nitric acid one leaf autumn alkali (or Securinine hydrochloride) 16mg

Citicoline 800mg

All the other join 100ml with 0.9% physiological saline.

Methods for the treatment of is with the embodiment I.

The treatment case

Age	The sex occupation	Diagnostic result	The morbidity time limit	Symptom before the treatment	Symptom after the treatment
					Symptom after the treatment		The 1st treats order journey 10 days (with embodiment II prescription)	20 days the 2nd courses for the treatment of (with embodiment I prescription)
					68 years old	The man cadre			Cerebral infarction basal part right side	So far 14 years	Left limb hemiplegia, the atrophy of muscle severe, myasthenia, elbow joint flexing hang down that wrist, finger grab that Chinese boxing stiff knee, left lower extremity tow, can't squat down, left limb is colder, left hand pastiness, atropurpureus, anoxic	Loosen in the sensation joint, knee joint, ankle-joint loosen, flexing, can do that squatting motion, left arm are raised 200cm, brain feels clear	That the left limb temperature is recovered is normal, leg flexible raise walking, left hand refer to ruddy, need not the crutch walking
62 years old	The male teacher	The left side cerebral infarction	So far 2 years	Right side limbs knee joint, ankle-joint, hip joint be stiff, lose function fully, right side limb muscle atrophy, elbow joint flexing, the wrist that hangs down, finger are grabbed fist, can't be squatted down	68 years old	The man cadre	Shank loosens, knee joint is bent knee, the someone holds up alternately to take a step in upper and lower building, right leg strength amount increases, appetite takes a turn for the better	The sensation brain is clear, walking is light, toe crookedly loosens, can be straight, swelling disappearance, arm can lift 40cm, finger can clench fist, can independent upper and lower the 5th buildings, need not crutch	Cerebral infarction basal part right side	So far 14 years
62 years old	The male teacher	The left side cerebral infarction	So far 2 years		50 years old	Male worker people			The left side cerebral infarction	So far 3 years	The right side hemiplegia of limb, myasthenia, the elbow joint flexing, finger is clenched fist, and lower limb are stiff, can't squat down, be blind in the left eye, left ear dysacousis, the right side limb temperature is on the low side, it is slow to pronounce, edema of lower extremity, and the knee joint following cyanosis of skin in right side is in obvious Hypoxia and ischemia state.	Right vision returns to 1.0, and auris dextra recovers the sense of hearing, and shank loosens, and is stronger, can do squatting motion, need not to rely on to help can sit down, stand up, can be without the crutch walking.	Right leg strength amount increases, and stands up to sit down easily, squats down easily, and lower extremity swelling and distension disappears, and is stable without the upper and lower six building walkings of crutch energy.
48 years old	Schoolmarm	Hypertensive cerebral hemorrhage left side Basal ganglia is hemorrhage	So far 3 years	Right side hemiplegia of limb, hand are lifted to the shoulder difficulty, and the right hand is clenched fist and can not be stretched out, and arm puts down and can not stretch, and leg difficulty in walking, right leg take a step to squat down, stand up to need by external force to the layman, right side muscular atrophy, loose, vertical wrist.	50 years old	Male worker people	The patient feels that brains is clear, and the right side limbs loosen, and it is strong to walk, and the right hand is clenched fist and can be stretched out, and squats down and stands up freely, and easily, right arm can stretch.	Right side brawniness, right arm are can be easily upper to be lifted, and stretches, and can put down the stretching, extension abduction, and it is stronger to walk, upper and lower building freely, hypermnesia, it is normal that gait is recovered substantially.	The left side cerebral infarction	So far 3 years

(continued)

50 years old	The woman cadre	Artery sample hardening cerebral thrombotic infarction	So far 2 years	Aphasia, the right side limbs are stiff, and instability of gait is not flexible, and elbow is counted on one's fingers, is bent in the obvious atrophy of right side limbs, unable.	Can say continuously that language reaches 7 words, it is more clear to pronounce, and the strength of walking increases, and elbow joint can stretch and raise, and right hand outward turning can oneself's domination.	Speech can be said 15 more than the word continuously, and the right side myodynamia strengthens, and it is more free and relaxed to walk, and the right hand can be clenched fist
50 years old	The woman cadre	Artery sample hardening cerebral thrombotic infarction	So far 2 years							15 days courses for the treatment of
(with embodiment II prescription)										15 days courses for the treatment of
(with embodiment II prescription)		10 years old	The man	Myasthenia gravis		The sagging type in upper eyelid: the eyes ptosis, the volume position disappears, and face is stiff, and mimetic muscle is amimia, faces upward face depending on thing.				Patient's transference cure
45 years old	The man	10 years old	The man	Myasthenia gravis			Myasthenia gravis	Cervical muscle and omoplate banding pattern: head turns forward, and it is unable to come back, and salivation is poker-faced	Patient's transference cure	Patient's transference cure
45 years old	The man	17 years old	The woman	Myasthenia gravis		Upper limbs flesh type: the morbidity upper limbs is sagging, can not lead along by hand, and grip descends, and it is unable to hold thing, the difficulty of writing.	Myasthenia gravis		Patient's transference cure	Patient's transference cure
63 years old	The woman	17 years old	The woman	Myasthenia gravis			Myasthenia gravis	Oblongata flesh type: asophia is clear, the difficulty of handling up, and xerophagia is not swallowed drinking-water and is choked from nose, heavy nasal sound, the general power of whole body sometimes, mouthful salivation.	Patient's transference cure	Patient's transference cure
63 years old	The woman	37 years old	The woman	Sequelae of infantile paralysis		The lower limb muscles atrophy of patient right side is walked lamely, and sole turns up.	Myasthenia gravis		Patient's transference cure	The atrophy muscle recovery approaches normally after treating 2 courses for the treatment of, walks lamely and obviously improves, and sole turns up and recovers normal.

Claims

1, a kind of composite medicinal injection for the treatment of hemiplegia is characterized in that its composition forms (by working concentration mg/100ml) and is: Cobastab₁400-800mg, Cobastab₆50-100mg, Cobastab₁₂5-10mg, danshen injections (crude drug content) 3000-6000mg, ligustrazine phosphat or Ligustrazine Hydrochloride 380-750mg, one leaf autumn of nitric acid alkali or Securinine hydrochloride 8-16mg, citicoline 500-1000mg, all the other are assigned to 100ml with 0.9% physiological saline.

2, parenteral solution according to claim 1 is characterized in that described danshen injections is pure danshen injections or compound injection of red sage root or sodium tashinone II A sulfonate injection.