CN1122241A

CN1122241A - Naomaitong injection for cerebral angiopathy

Info

Publication number: CN1122241A
Application number: CN 95109431
Authority: CN
Inventors: 牛俊江
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-09-18
Filing date: 1995-09-18
Publication date: 1996-05-15

Abstract

Naomaitong injection consists of red sage 100-300 portions, Vinourutoni 5-15 portions, cytidine diphosphocholine 5-10 portions, coenzyme A 1-2 portions, adenosine triphosphate 0.4 portions and water 240-770 portions. The said medicine has the function of retarding clotting of red blood cell and thrombocyte, can prevent and cure thrombosis, encephaledema and senile dementia, promote angiogenesis and prevent radioactive ray injury and inflammation. It is used via either arteria carotis injection or phleboclysis.

Description

Naomaitong injection for cerebral angiopathy

The present invention relates to medicine, is a kind of compound recipe water formulation for the treatment of brain arteries and veins angiopathy.

At present, in treatment brain swift pulse disease, the medicine that uses mostly is that curative effect is low, treatment cycle is long, poison is paid effect greatly, even the meeting that has disables, and do not find a kind of treatment cerebral thrombosis acute stage, the new medicine of comprehensive therapeutic effects such as chronic sequela, apoplexy sequela and thromboangiitis obliterans, superficial phlebitis so far as yet.

The purpose of this invention is to provide a kind of Naomaitong injection for cerebral angiopathy, single to solve existing treatment brain swift pulse medicine purposes, curative effect is low, the cycle is long, poison pays effect big problem, for brain swift pulse patient provides a kind of comprehensive therapeutic effect high new drug.

The object of the present invention is achieved like this: this injection contains Radix Salviae Miltiorrhizae, troxerutin, citicoline, coenzyme A, adenosine triphosphate, and is formulated through scientific technology, its proportioning following (weight portion)

Radix Salviae Miltiorrhizae 100-300 troxerutins 5-15

Citicoline 5-10 coenzyme As 1-2

Adenosine triphosphate 0.4 water 240-770

Its production technology comprises: select materials, be mixed, filtration, fill, sterilization, packing warehouse-in operation.

1, select materials:

A, Radix Salviae Miltiorrhizae are selected powder for use or are selected the Radix Salviae Miltiorrhizae water formulation for use;

B, troxerutin are selected powder for use or are selected the troxerutin water formulation for use;

C, citicoline are selected powder or citicoline water formulation for use;

D, coenzyme A are selected powder or coenzyme A water formulation for use;

E, adenosine triphosphate are selected powder or adenosine triphosphate water formulation for use;

2, be mixed:

Above-mentioned a, b, c, d, e powder are put into the container of belt stirrer in proportion, add 240-770 parts of distilled water then, stir and ended in 5-15 minutes;

3, filter:

Adopt filter centrifugal or filter to filter;

4, fill:

Adopt filling and sealing machine, every 20ml;

5, sterilization:

Adopt flowing steam sterilization, 100-150 ℃ of vapor (steam) temperatures, the time is more than 30 minutes;

6, packing warehouse-in:

Lucifuge, airtight, room temperature are preserved, storage life 3 years.

It is pale brown, clear and bright bright that this injection is, and do not have muddy, nothing precipitation.

Using method: the hemiplegia that cerebral thrombosis is caused, aphasia, dull-witted, apoplexy sequela, Menieres disease, the neurasthenia, quadriplegia, syndrome before the coronary heart disease infraction, hypertension, arteriosclerosis, thromboangiitis obliterans, thrombophlebitis, varicosis, diseases such as edema are effective in cure, but carotid artery injection, each 20ml is grown up, the next day once, five times is a course of treatment, 3-5 days can repeat to use by the course of treatment after the drug withdrawal, perhaps intravenous drip, and each 20ml is grown up, glucose injection 250-the 500ml that adds normal saline or 5-10%, once a day, 10 times is a course of treatment, and 3-5 days can repeat to use by the course of treatment after the drug withdrawal.

This medicine compared with prior art has the following advantages: 1) this product has the effect that suppresses erythrocyte and platelet aggregation, can prevent and treat thrombosis, and the content of oxygen in blood vessel dilating, the increase blood is arranged, and reduces blood viscosity; Can prevent and treat cerebral edema, promote neovascularity to generate, activate brain cell, the accelerator nerve functional rehabilitation; Can prevent and treat senile dementia, resisting radiation damage, anti-inflammatory effect are arranged, purposes is wide; 2) curative effect height reaches more than 94% according to 130 routine clinical practice statistics effective percentage, shortens a week than the other drug treatment cycle; 3) toxicity is low, does not find the effect of paying so far; 4) technology is simple, and is easy to use.

Illustrate below:

Example 1: No. 1, Naomaitong injection for cerebral angiopathy, its proportioning is as follows: (weight in grams)

Radix Salviae Miltiorrhizae 300 troxerutins 5

Citicoline 5 coenzyme As 1

Adenosine triphosphate 0.4 water 635

Compound method:

1, select materials: Radix Salviae Miltiorrhizae, troxerutin, citicoline, coenzyme A, adenosine triphosphate all adopt powder;

2, be mixed: pour above-mentioned powder into band in proportion respectively and stir in the container of device, adding distil water 635 grams stirred 10 minutes then;

3), filter: adopt filter to filter;

4), fill: use the filling and sealing machine filling and sealing, every 20ml;

5), sterilization: adopt flowing steam sterilization, temperature is 110 ℃, 30 minutes time;

This medicine is suitable for the carotid artery injection, and the hemiplegia aphasia that cerebral thrombosis is caused has specially good effect, if production lot can increase greatly in proportion.

No. 2, example 2, Naomaitong injection for cerebral angiopathy, its proportioning is as follows: (weight in grams)

Radix Salviae Miltiorrhizae 100 troxerutins 15

Citicoline 10 coenzyme As 2

Adenosine triphosphate 0.4 water 265

Compound method is with example 1.

This medicine is suitable for intravenous drip, to reducing blood viscosity specially good effect is arranged.

Claims

1, a kind of Naomaitong injection for cerebral angiopathy contains Radix Salviae Miltiorrhizae, troxerutin, citicoline, coenzyme A, adenosine triphosphate composition, and it is characterized in that: weight proportion is as follows: part

Radix Salviae Miltiorrhizae 100-300 troxerutins 5-15

Citicoline 5-10 coenzyme As 1-2

Adenosine triphosphate 0.4 water 240-770

2, injection according to claim 1 is characterized in that: No. 1 its best proportioning of Naomaitong injection for cerebral angiopathy is as follows: (weight in grams)

Radix Salviae Miltiorrhizae 300 troxerutins 5

Citicoline 5 coenzyme As 1

Adenosine triphosphate 0.4 water 635

3, according to the described injection of claim l, it is characterized in that: No. 2 best proportionings of Naomaitong injection for cerebral angiopathy are as follows: (weight in grams)

Radix Salviae Miltiorrhizae 100 troxerutins 15

Citicoline 10 coenzyme As 2

Adenosine triphosphate 0.4 water 265

4, injection according to claim 1, its production technology is characterised in that and comprises: selects materials, is mixed, filtration, fill, sterilization, packaging process, flowing steam sterilization is adopted in sterilization, and vapor (steam) temperature is 100-150 ℃, and the time is more than 30 minutes.

5, its use characteristic of injection according to claim 1 is: the hemiplegia that cerebral thrombosis is caused, aphasia, dull-witted, apoplexy sequela, Menieres disease, the neurasthenia, quadriplegia, syndrome before the coronary heart disease infraction, hypertension, arteriosclerosis, thromboangiitis obliterans, thrombophlebitis, varicosis, diseases such as edema are effective in cure, but carotid artery injection, each 20ml is grown up, the next day once, five times is a course of treatment, 3-5 days can repeat to use by the course of treatment after the drug withdrawal, perhaps intravenous drip, each 20ml is grown up, glucose injection 250-the 500ml that adds normal saline or 5-10%, once a day, 10 times is a course of treatment, can heavily use by the course of treatment in 3-5 days after the drug withdrawal, effective percentage is more than 94%.