CN1224402C - Use of Euproctis pseudoconspersa in preparing medicine for treating diseases of gastrointestinal tract - Google Patents

Abstract

The present invention discloses application of Euproctis pseudoconspersa in preparing medicine for treating gastrointestinal diseases, which belongs to the field of the use and the application of the Euproctis pseudoconspersa. A preparing product of the Euproctis pseudoconspersa contains a plurality of nutrient contents necessary for human bodies; the Euproctis pseudoconspersa has the functions of diminishing inflammation, promoting blood circulation, promoting menstruation, activating the muscle, and improving partial and systemic microcirculation for human bodies so as to reinforce the immunological function of the human bodies, and has the efficacy of removing the blood stasis, pain, anesthesia and turgescence of the human bodies so as to increase the ability to resist diseases; the Euproctis pseudoconspersa has particularly obvious application effect especially in the preparation of the medicine for treating chronic gastritis, atrophic gastritis, canker, colonitis and gstrointestinal diseases.

Description

Euproctis pseudoconspersa is as the application of the medicine of preparation treatment gastroenteropathy

Patent application of the present invention is to be on April 23rd, 1999 applying date, and the application people is Jiang Jinhua, and application number is: 99112162.7, and invention and created name is: the dividing an application of the application for a patent for invention of " application of Euproctis pseudoconspersa in pharmacy, cosmetics, health product ".

Technical field

The present invention relates to the purposes of Euproctis pseudoconspersa, relate in particular to Euproctis pseudoconspersa as the purposes in the application of the medicine of preparation treatment gastrointestinal disease.

Background technology

Euproctis pseudoconspersa is a kind of natural wild insecticide that is grown on the multiple tree, belongs to the mature larva of Lepidoptera, cnidocampa flavescens walker section (Cnidocampa, flavescens walker).This insecticide has been made detailed record to distribution, morphological characteristic, the biological characteristics of cnidocampa flavescens walker in the 779-780 page or leaf in " Chinese forest insecticide " book of being edited by comrade Xiao Gangrou of China Forest publishing house the 1st publication and distribution April in 1992.In this book to multiple forest and fruit trees such as cnidocampa flavescens walker harm Semen Juglandis, Punica granatum L., Fructus Pruni, peach, Fructus Kaki, Fructus Jujubae, Fructus Mali pumilae, pears, Cortex Sapii Radicis, sweetgum, Flos Osmanthi Fragrantis, Melia azedarach L., Radix Cinnamomi porrecti, Paulownia, taked to go to prevent and treat the harm that cnidocampa flavescens walker is caused from methods of preventing and treating such as artificial control, light trap, chemical prevention, Biological controls, thick as the mature larva body, the long 19-25mm of body, the head yellowish-brown is hidden under the shirtfront.The chest yellow green, body is from second joint, each saves the lineback both sides a pair of scolus, with third and fourth, ten joints serve as greatly, growing on the scolus has the black seta; The body back of the body has the big speckle of puce, and front and back are roomy, the narrow dumb-bell shape that is fine in middle part, and there are four brown stigmas at the minor details back side; Respectively there are 9 scolus the body both sides, and there are 2 blue longitudinal grins at the middle part, side, the upper spiracel line nattierblue, and subspiracular line is faint yellow.As the purposes of Euproctis pseudoconspersa, particularly the purposes in pharmacy, cosmetics, field of health care products is reported seldom to some extent.Put down in writing its name as the medical usage of Euproctis pseudoconspersa 2098-2099 page or leaf in " the Chinese medicine voluminous dictionary " of new medical college writing by Jiangsu of the Shanghai People's Press the 1st printing distribution October in 1977 and be called Monema flavescens Walker, have another name called Euproctis pseudoconspersa in the Compendium of Material Medica, base was the worm cocoon of slimacodiidae insecticide cnidocampa flavescens walker originally, former animal is cnidocampa flavescens walker Monema flavescens walker, gather August, sweet in the mouth, flat, nontoxic, cure mainly infantile convulsion, infantum tetanus, the epilepsy disease, to control infantile neonatal tetanus is example, its prescription is one piece of an Euproctis pseudoconspersa, one piece of true Bombyx Batryticatus (stir-fry), greasy powder Xiao Xu.Grind well, transfer filling, take off poisonous substance with Herba Menthae nature juice.Relevant Euproctis pseudoconspersa is used to prepare the purposes in fields such as the medicine for the treatment of other disease, cosmetics, health product does not still have any report so far.

Summary of the invention

The object of the present invention is to provide the purposes of Euproctis pseudoconspersa, promptly in the new application of pharmacy.

In fact, the present invention relates to the application of Euproctis pseudoconspersa as the medicine of preparation treatment chronic gastritis, atrophic gastritis, Peptic Ulcers, colitis, gastroenteropathy.

Relate to the application of Euproctis pseudoconspersa as the medicine of preparation treatment hyperosteogeny, intervertebral disk hernia, spinal canal stenosis, ankylosing spondylitis, paraplegia, spinal nerves pathological changes disease.

Relate to Euproctis pseudoconspersa and hinder the application of the medicine of the joint disease that causes as preparation treatment rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, lumbago and skelalgia wind and cold, rheumatism.

Relate to the application of Euproctis pseudoconspersa as the medicine of preparation treatment femur head necrosis, various bone injury sequela diseases.

Also relate to the application of Euproctis pseudoconspersa as the medicine of preparation treatment lupus erythematosus, scleroderma, dermatomyositis connective tissue disease.

Also relate to the application of Euproctis pseudoconspersa as the medicine of preparation treatment neuritis, nerve injury, muscular strain, myasthenia, atrophy, sclerosis, autonomic nervous dysfunction, neuromuscular disease.

The invention still further relates to Euproctis pseudoconspersa simultaneously as the application in the medicine of preparation treatment cyclomastopathy, skin ulceration dermatitis, cold tracheitis, senile dementia, special difficult diseases; Treat the application of the medicine of AIDS, tumor, disease of immune system as preparation.

Another object of the present invention is to provide the application of Euproctis pseudoconspersa at the preparation cosmetics.

A further object of the present invention is to provide the application of Euproctis pseudoconspersa at the preparation health product.

In order to understand essence of the present invention better, pharmacological testing and the result with the prepared product of Euproctis pseudoconspersa illustrates its new purposes and new purposes in preparation cosmetics, health product in pharmaceutical field below.

Adopt Euproctis pseudoconspersa (cnidocampa flavescens walker mature larva), be used as medicine, be prepared into sterile solution, be distributed into the injection that 2ml/ props up concentration and be loaded on sealing in the injection medicine bottle, sterilize that it is standby to make product with the existing preparation technology of Chinese medicine (pure water law) with its integral body.

Adopt Euproctis pseudoconspersa (cnidocampa flavescens walker mature larva) 5kg, be used as medicine with integral body, conventional pharmaceutical technology and the necessary pharmaceutical excipient (Mel) of adding with Chinese medicine preparation are prepared into honeyed pill (1g/ ball) or sublimed preparation (0.2g/ ball), also can add necessary pharmaceutical excipient (magnesium stearate) and make tablet (0.1g/ sheet), or make capsule dress powder (0.2g/ grain), it is standby to make product behind package encapsulation.

Qualitative detection analytical test through pharmaceutical test department to product, assert in the Euproctis pseudoconspersa prepared product and mainly contained: acetylcholine, aspirin, all-round cecropin, interferon, immunoglobulin, adenosine triphosphate (ATP), nutritions such as trace element zinc, several amino acids, chlorophyll and vitamin.Because medicine of the present invention is the pure-natural biological preparation, the various nutritions that it contained have more the characteristics that its human body is convenient to absorb, this is known technology already in medicine technology field the critical positions that various nutritions are occupied in human body, and its effect is respectively:

Acetylcholine, a kind of quaternary ammonium compound that important biomolecule effect is arranged is one of major neurotransmitter involved in the nervous system.The tip of some neurocyte among somatic movement nerve, parasympathetic and orthosympathetic preganglionic fibre, parasympathetic postganglionic fibers, the orthosympathetic postganglionic fibers of part and the central nervous system, all discharge micro-acetylcholine at excitation time, cell excitement or inhibition that these tips are arranged, thereby produce various physiological effecies, as the vasodilation of Skeletal Muscle Contraction, some organ, bradycardia, contracted pupil, enterogastric peristalsis etc.After acetylcholine discharges, be stored soon in the acetylcholine esterase that discharges the place and be hydrolyzed into choline and acetic acid, make the effect of acetylcholine have locality, transience, it is necessary that at this moment acetylcholine is finished its function as mediator.

Aspirin also claims aspirin, antipyretic analgesic, white crystals or crystalline powder, and little acid of distinguishing the flavor of is slightly soluble in water.Be used to cure cold, generate heat, headache, toothache, arthralgia and rheumatism, side effect is little.

All can cecropin be the requisite a kind of biological antibiotic element of human body, it can be prevented source of disease to continue harm or eliminate source of disease, and be inhibited.

Interferon, a kind of protein that virus is bred in cell, about 20000-10000 of molecular weight of suppressing.By the humans and animals cell at virus, antibacterial, fungus, protozoon, rickettsia, phytohaemagglutinin etc., and the double-stranded ribonucleotide of polymerized nucleoside acids such as double stranded RNA and synthetic is induced down and is produced, any interferon of inducing generation can suppress the propagation of multiple virus.Interferon is not the propagation that directly suppresses virus, but inducing cell is synthetic another kind of virus multiplication is had inhibiting protein, and interferon comprises effect in some cancer preventing and treating virosis, among actively carrying out.

Immunoglobulin claims again " antibody ", by the B cell of human body under antigenic stimulus, the synthetic one group of special globulin of plasma cell that the differentiation division forms, it is the pillar of immune function of human body, can suppress the immunoreation of human body, improve the immunologic function of human body, reduce the invasion of disease.

Adenosine triphosphate (ATP) is by the body energy mixture, and it is that human body carries out the necessary composition of comings and goings.

This all is the necessary nutrition of human human body for trace element zinc, aminoacid, chlorophyll and vitamin.

The Euproctis pseudoconspersa prepared product not only is the pure-natural biological preparation in sum, and keeps the active ingredient of natural biological, is that human nutrition composition institute is indispensable.From the Main Ingredients and Appearance acetylcholine that wherein contained, aspirin, all can cecropin, interferon, immunoglobulin, adenosine triphosphate (ATP) all have the raising immune function of human body, the effect of microcirculation improvement system is to effective propagation, muscle of invigorating blood circulation, stimulate the menstrual flow, live that suppresses virus, improve the part and systemic microcirculation reaches blood stasis dispelling, the pain of dispelling, the fiber crops of dispelling, dispelling to swell has its special effect.

The test example:

1, acute toxicity test

(1) test is prepared

A, to select 60 of Kunming white mice, weight be 18-22g (male and female each 30)

The processing of B, test specimen: get medicine of the present invention (ball, pellet, sheet, all can loose) 30g, add distilled water 50ml, forming content through grinding is that the full slurry of 600mg/ml is standby.

(2) oral medication: get 30 of Kunming white mice (each 15 of male and female), weight is 18-22g/, every white mice gives the equal serosity 0.5ml of sample and irritates stomach, give altogether twice (be 4 hours blanking time), accumulated dose is 1ml (its dosage is equivalent to 600g/kg), observes all healthy existence of white mice 10 days, do not have any toxicity, compare zero difference through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group.

(3) injection: get 30 of Kunming white mice (each 15 of male and female), weight is 18-22g/, every white mice gives drug injection 0.25ml of the present invention intramuscular injection, give altogether twice (be 4 hours blanking time), accumulated dose is 0.5ml (its dosage is equivalent to 25ml/kg), is more than 400 times of plan adult consumption 0.06ml/kg.Observed 10 days, all healthy existence of white mice does not have any toxicity, compares zero difference through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group.

2, accumulation toxicity test

(1) test is prepared

A, select and make 30 (male and female each 15) rat 6-8 week

The processing of B, test specimen: get medicine of the present invention (ball, pellet, sheet, all can loose) 30g, add distilled water 50ml, through grinding to form screened stock, can add 1% right Sodium Tvlose suspending, the homogenate of making content and be 600mg/ml is standby.

(2) oral medication: get 30 of rat (each 15 of male and female), divide three dosage groups, rat by picked at random is divided into three groups, every group 10, (each 5 of male and female), give every rat 0.4ml every day respectively, 0.25ml, 0.1ml the sample homogenate irritate stomach (its dosage be respectively 240g/kg, 150g/kg, 60g/kg, 2000 times of clinical consumption 0.12g/kg are equivalent to plan to be grown up, 1250 times, 500 times), observed 30 days, the all healthy existence of rat, there is not any toxicity, through the anatomic observation hemogram, liver function, each organs and tissues form finding and matched group be zero difference relatively, does not have savings in the rat body.

The above results explanation: pharmaceutical preparation of the present invention is safe to the medicine that is used for the human clinical, and it is nontoxic, have no side effect, do not have savings.

3, strong bone test: the femur head necrosis pathological changes that causes 10 Canis familiaris L.s by modus operandi, adopt the ailing relevant subcutaneous intramuscular injection in acupuncture point with medicine injection of the present invention, once a day, each 4ml, through testing 3 monthly healthy existence, there is not any toxicity, existing 9 Canis familiaris L.s can return to original degree, freedom of movement, article 1, Canis familiaris L. is also weaker, and 3 Canis familiaris L.s carry out anatomic observation to warp to treating preferably, its hemogram, liver function, each organs and tissues form finding and matched group zero difference, do not have savings in the Canis familiaris L. body, femoral head and each connective tissue are normal.Its presentation of results: pharmaceutical preparation of the present invention all has treatment and preventive effect preferably to the disease of the femur head necrosis of human body, bone injury sequela, various joint disease, sclerotin aspect.

4, clinical drug trial of the present invention

In the acute toxicity test of process to medicine of the present invention, accumulation test, after the simulation therapeutic test of Canis familiaris L., medicine of the present invention is carried out testing through the clinical practice in 2 years in three tame hospitals above county level, its test method and effect: hyperosteogeny, intervertebral disk hernia, spinal canal stenosis, ankylosing spondylitis, paraplegia, spinal nerves pathological changes disease is treated 398 examples altogether, adopt the ailing relevant subcutaneous intramuscular injection in acupuncture point, once a day, each 2-4ml, treatment is one month continuously, 307 routine patient's recoveries from illness are arranged, other patients treatment continuously were almost recovered after two months, and its healing reaches more than 98%, and the treatment effective percentage reaches 100%; Rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis, lumbago and skelalgia, femur head necrosis, bone injury sequela are treated 376 routine patients altogether, adopt the ailing relevant subcutaneous intramuscular injection in acupuncture point, once a day, each 3ml, to rheumatic arthritis, scapulohumeral periarthritis, lumbago and skelalgia and bone injury sequela patient 289 examples, be almost recovered through treating 1.5 months, it is normal that function is recovered substantially, to 87 routine patients of rheumatoid arthritis, femur head necrosis disease through treating 3 monthly whole recoveries from illness of the longest patient treatment 2 months.Connective tissue diseases such as scleroderma, dermatomyositis, lupus erythematosus are treated 29 examples, adopt the relevant subcutaneous intramuscular injection in acupuncture point of focus, once a day, each 2ml, treatment time is that 1-3 did not wait in individual month, and reveal any symptoms improves obviously clinically, and recovery from illness is very fast.

To chronic gastritis, atrophic gastritis, Peptic Ulcers, colitis, functional gastrointestinal disorder 386 routine patients, to neuritis, nerve injury, myasthenia, amyotrophy, autonomic nervous dysfunction, neuromuscular disease 188 routine patients; To cyclomastopathy, skin ulceration dermatitis, cold tracheitis, senile dementia, special difficult diseases 44 routine patients; To tumor, AIDS, disease of immune system 12 routine patients, treat 632 examples altogether, Therapeutic Method all adopts oral pill of the present invention (red or capsule dress powder), every day three times, each 1-2g obviously improves through treating 20 days symptoms of 386 routine functional gastrointestinal disorder, treats and promptly thoroughly cures in three months, especially better to cold gastrointestinal tract patient effect, and the atrophic gastritis patient needs 4-5 month treatment to fully recover; Treatment to patients with neuromuscular disease 188 examples focuses on trophic nerve, promotes neural microcirculation, improve sleep quality and resistance against diseases, in Therapeutic Method, adopt oral medicine pill, every day three times, each 1g and every day secondary, the medicated powder wine of each 10ml, 4 months treatment times were clearly better, and were almost recovered in 6 months; To special difficult diseases, the disease of immune system patient treats 58 examples altogether, and general treatment took an evident turn for the better in 6 months, and body immune function is strengthened, and thoroughly curing needs 10 months treatment time.

By the clinical trial explanation, medicine of the present invention is effective to treatment of diseases, it is by ailing relevant subcutaneous intramuscular injection in acupuncture point or oral drugs, the patient had the muscle of invigorating blood circulation, stimulate the menstrual flow, live, improve that local microcirculation reaches blood stasis dispelling, dispel pain, the fiber crops of dispelling, the bullate function of dispelling, strengthen the immunologic function of human body, strong human quality, the infringement that eliminates a disease.Now model case is taken passages as follows:

(1) try to gain certain, the woman, 42 years old, the patient suffered from waist 4.5 waists 5 sacrums 1 intervertebral disk hernia, spinal canal stenosis, 2 operations are success all, two leg pain fiber crops are serious, after see a doctor.Through adopting the ailing relevant subcutaneous intramuscular injection in acupuncture point (every day 1 time, 3ml at every turn) treatment, disease is clearly better after 1 month, and recovery from illness after two months is followed up a case by regular visits to after the healing apart from modern having and do not seen recurrence in 4 years.

(2) Song, the woman, 60 years old, trouble rheumatoid disease more than 20 year, cervical vertebra, finger-joint swell and ache, and how tame hospital therapy is crossed but recovery from illness all the time, and the state of an illness increases the weight of to seek medical advice afterwards recently, through adopting the ailing relevant subcutaneous intramuscular injection in acupuncture point (once a day, each 3ml) treatment, recovery from illness in three months, after follow up a case by regular visits to and do not see recurrence in existing 3 years so far.

(3) Wang, the man, 45 years old, because of the cervical region wound causes incomplete paraplegia, national various big hospital hospitalization 3 years, two upper and lower extremities activities were malfunctioning, amyotrophy, the pain sensation disappears substantially, after the treatment of seeing a doctor.Through adopting the ailing relevant subcutaneous intramuscular injection in acupuncture point (once a day, each 4ml) treatment 4 months, the pain sensation is recovered, and activity often becomes substantially, and through continuing treatment 3 months, limb activity is normal, can participate in various normal work.

(4) Song, the woman 45 years old, suffered from dermatomyositis 8 years, the whole body myasthenia, bed fully is through adopting ailing related muscles injection for curing (each 4ml once a day) treatment 2 months, just can assist in and walk, 4 months basic self-cares, but because patient's economic cause fails to continue treatment, after follow up a case by regular visits to the patient and still can accomplish that the individual is basic in existing 3 years so far and take care of oneself.

(5) Xu certain, the woman 50 years old, suffers from the bilateral femoral head necrosis, once arrived national various big hospital diagnosis and treatment, after hear then and seek medical advice that the subcutaneous intramuscular injection for treating in ailing relevant acupuncture point is adopted (once a day in the back after diagnosing, each 4ml) treatment is after 1 month, and its disease obviously alleviates, and continues treatment recovery from illness in three months.

(6) Zhang, the man, 39 years old, suffer from chronic gastritis, once crossed all recovery from illness to the national hospital diagnosis and treatment, after diagnoses and treatment, oral medicine of the present invention (pill every day 3 times, each 2g) treatment was fully recovered in two months.

(7) Lee, the man, 46 years old, year surplus the initiation autonomic nervous dysfunction disease 20 once took multiple medicine, but did not thoroughly cure after the trouble nerve injury.After treatment, oral medicine of the present invention (capsule dress powder every day three times, each 1g) and drink-service medicated powder infusing drugs in wine (every day secondary, each 10-20ml) two month, disease is clearly better, and continues treatment and is almost recovered after three months, follows up a case by regular visits to the patient and does not see recurrence so far in 3 years.

(8) Liu, the woman, 58 years old, suffer from surplus the cold tracheitis 20 year, whenever the outbreak of catching cold, can not go to bed whole night when serious, cough, expectorant is successive, take related drugs and can only stop PD, always healing.Through treatment, 20 days diseases of oral medicine of the present invention (honeyed pill, every day three times, each 2g) were clearly better, and treat to be completely recovered in two months, visit the patient subsequently, did not see recurrence apart from modern 2 years.

The specific embodiment

Provide the specific embodiment of the application of Euproctis pseudoconspersa of the present invention in preparation medicine, cosmetics, health product below.

Embodiment 1

Choose Euproctis pseudoconspersa (cnidocampa flavescens walker mature larva), be used as medicine with its integral body, fabricating technology (pure water law with the modern Chinese medicine injection, but also water alcohol method) is prepared into sterile solution (also can again through being processed into corresponding dry product), be distributed into pack into the sealing in the injection medicine bottle, sterilization of injection that 2ml/ props up concentration and make the product of Euproctis pseudoconspersa extract, dispatch from the factory through packing again.

Embodiment 2

Choose Euproctis pseudoconspersa (cnidocampa flavescens walker mature larva) 5kg, be used as medicine with its integral body, be prepared into pill (honeyed pill, the watered pill, wax pill all can) with the conventional pharmaceutical technology (moulding method for making) of Chinese medicine pill, every ball 1g dispatches from the factory after packing.

Embodiment 3

Choose Euproctis pseudoconspersa (cnidocampa flavescens walker mature larva) 5kg, with its whole medication, be prepared into coated tablet after the conventional fabricating technology adding necessary additional excipient with modern Chinese medicine tablet preparation for oral administration, every 0.2g dispatches from the factory after packing.

Embodiment 4

Choose Euproctis pseudoconspersa (cnidocampa flavescens walker mature larva) 5kg,, make powder with the conventional technology of preparing of Chinese medicine powder with its whole man's medicine, pack by the 2g/ bag, dispatch from the factory after packing again, also powder can be packed (0.2g/ grain) with capsule, after packing, dispatch from the factory.

Embodiment 5

It is the Chinese liquor of 40-60% that powder among the embodiment 4 is immersed alcohol content by every 50g, by the fabricating technology of Chinese medicine medicated wine and add an amount of sugar, Mel and toner etc. and be prepared into medicated wine, dispatches from the factory after packing.Also can directly soak according to the above ratio, get its wine liquid and directly take.

Embodiment 6

A kind of cosmetics with treatment acne, freckle, it is to be substrate with existing ordinary cosmetics, with the injection of embodiment 1 preparation directly and substrate stir, mixed proportion is substrate and ratio (weight portion) 3-5 of injection: 1; To acne, the heavier person of freckle, also can directly injection made among the embodiment 1 be applied in face.

Embodiment 7

A kind ofly can improve immune function of human body, it is strong to invigorate health effectively, reduce the health promoting beverage of disease, it be with Euproctis pseudoconspersa (cnidocampa flavescens walker mature larva) with its integral body as primary raw material, add an amount of sugar, Mel, be prepared into oral liquid according to existing oral liquid fabricating technology, dispatch from the factory behind sealing, sterilization packaging with vial, to middle-aged and elderly people, body constitution difference person, noneffectives, puerpera all have preferable body constitution restitution, general dose 2-3 day once, each 2ml.

Embodiment 8

A kind of health care medicinal granules of powder, it is whole as primary raw material with Euproctis pseudoconspersa (cnidocampa flavescens walker mature larva), adds necessary starch, sugar as auxiliary material, makes powder shape electuary with existing conventional powdered agent technology of preparing, dispatches from the factory after packing.These product can be middle-aged and elderly people, and the person of having a delicate constitution, osteoporosis person provide a kind of health instant powder, general consumption once a day, each 0.5g, warm boiled water.Strong, energetic with meeting body constitution for a long time, its main effect utilize the necessary acetylcholine of the contained somebody's body of Euproctis pseudoconspersa, aspirin, all can cecropin, interferon, immunoglobulin, adenosine triphosphate (ATP), trace element zinc, several amino acids, vitamin partly replenish needed by human body, to improve the microcirculation of part and whole body, reach the enhancing immune function of human body, increase resistance against diseases, improve human quality's purpose.

Claims (1)

1, Euproctis pseudoconspersa is as the application of the medicine of preparation treatment atrophic gastritis, colitis disease.