CN1223883A - Anti-lung cancer medicine - Google Patents

Abstract

A medicine for lung cancer is prepared from 10 Chinese-medicinal materials such as cordyceps, human placenta, stemona root, lily bulb, liquorice root, etc, and features distinct curative effect for early lung cancer, the stabilizing and improving effect for middle-stage lung cancer, and elongating life by 5 years for operated patients.

Description

A kind of anti-lung-cancer medicament

The present invention relates to a kind of cancer therapy drug.

Pulmonary carcinoma is one of modal malignant tumor, nearly half a century many countries and regions pulmonary carcinoma M ﹠ M all increasing year by year, particularly evident in the male citizen.The primary disease cause of disease is not clear and definite fully as yet at present, but shows that according to epidemiologic data primary disease and smoking, atmospheric pollution and some occupational factor such as asbestos, arsenic, chromium, Colophonium and some radioactive substance have substantial connection, and endocrine regulation may be used in the shaft raising cooperation.Modern medicine mainly adopts methods such as operation, radiation and chemotherapy to primary disease, excision is a kind of of curative effect the best in the various Therapeutic Method, yet, about 80% lung cancer patient has not had surgical condition when making a definite diagnosis, in operable 20% case, five year survival rate also will descend, and the later stage also will recur, and five year survival rate is very low.

The objective of the invention is: a kind of anti-lung-cancer medicament is provided, and it has obvious curative effects to early stage of lung cancer patient, to mid-term patients with lung cancer can stablize focus, improve symptom, can prolong life, improve five year survival rate the operation therapist.

Technical scheme of the present invention is: a kind of anti-lung-cancer medicament, its composition comprise (1) Cordyceps, (2) Placenta Hominis, (3) Radix Stemonae, (4) Bulbus Lilii, (5) Radix Glycyrrhizae.

The further technical scheme of the present invention is: a kind of anti-lung-cancer medicament, its composition comprise (1) Cordyceps, (2) Placenta Hominis, (3) Radix Stemonae, (4) Bulbus Lilii, (5) Radix Glycyrrhizae, (6) Radix Astragali, (7) Radix Scutellariae, (8) Radix Asparagi, (9) Radix Ophiopogonis, (10) Radix Platycodonis.

The present invention's technical scheme more specifically is: a kind of anti-lung-cancer medicament, and the part by weight of described each composition is:

(1) Cordyceps 5--10 gram;

(2) Placenta Hominis 5--10 gram;

(3) Radix Stemonae 5--12 gram;

(4) Bulbus Lilii 6--12 gram;

(5) Radix Glycyrrhizae 2--9 gram;

(6) Radix Astragali 10--30 gram;

(7) Radix Scutellariae 6--12 gram;

(8) Radix Asparagi 10--15 gram;

(9) Radix Ophiopogonis, 10--15 restrained;

(10) Radix Platycodonis 6--12 gram.

With behind various Chinese medicine ingredients mixing, the pulverization, make pill in the such scheme, also can make liquor even injection.

The pharmacological action of each composition is as follows among the present invention:

Cordyceps--QI invigorating kidney tonifying, hemostasis and phlegm is used for the chronic cough dyspnea due to deficiency, impairment and cough spitting of blood, impotence and seminal emission, soreness of waist and knee joint.

Bavin river car--the kidney warming is mended smart, and benefiting QI and nourishing blood is used for asthenia, night sweat, cough and asthma etc.

The Radix Stemonae--nourishing the lung to keep the adverse QI downward cough-relieving is used for new chronic cough and coughs, lung impairment and cough, and pertussis is used for deficiency of YIN phthisical cough etc.

Bulbus Lilii--nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization is used for deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded.

Radix Glycyrrhizae--spleen reinforcing stomach function regulating, QI invigorating, weakness of the spleen and stomach, severe palpitation etc.

Huang Shi--invigorating QI to consolidate the body surface resistance, the deficiency of vital energy, the diuresis poison holding, interior-heat is quenched one's thirst, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema is had blood in stool, carbuncle subcutaneous ulcer, QI invigorating invigorating middle warmer etc.

Radix Scutellariae--heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus etc.

Radix Asparagi, Radix Ophiopogonis--nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid, and is used for dryness of the lung dry cough, and expectoration is sticking, dry throat and mouth, dryness of the intestine constipation etc.

Radix Platycodonis--lung qi dispersing, sore-throat relieving eliminates the phlegm, and is used for cough with copious phlegm, pharyngalgia out of breath uncomfortable in chest, hoarseness, lung abscess vomiting bloody pus etc.

Report with relevant pharmacological evaluation illustrates therapeutical effect of the present invention below:

One. the laboratory report of anti-lung tumor effect: (Shanghai Pharmaceutical Inst., Chinese Academy of Sciences)

1. animal: the 18--22g Kunming mouse, property early, adults is provided by Chinese Academy of Sciences's Shanghai Experimental Animal Center.

2. tumor kind: Lowis pulmonary carcinoma, this institute tumor kind that goes down to posterity for a long time.

3. trial drug and preparation: provided and prepared by Suzhou Medical College, drug level is 2g/ml.

4. dosage and approach: 5g/Kg * 10 day, oral administration.

5. result:

Dosage approach Mus is counted heavy control rate pH value medicine (g/Kg * sky) the %NS Po 11 1.93 ± 0.71 of tumor weight ± SD tumor

Anticarcinogen 5g/Kg * 10 day Po 10 1.27 ± 0.49 34% 10.05

According to above result, anti-lung-cancer medicament has the growth effect of obvious suppression mice Lowis pulmonary carcinoma.

Two. hemolysin (IgM) is measured: (Suzhou Medical College) method of inspection: with reference to Li Yikui chief editor's herbal pharmacology experimental methodology (Science and Technology of Shanghai publishing house, 1991, P160) assay: get 63 of the healthy BALB/C mice of 18--22g, male and female half and half, be divided into 6 groups (seeing the following form) at random, according to the form below dosage grouping two weeks, inject 5% chicken erythrocyte 0.2ml in the 10th day every Mus abdomen shin of administration and carry out immunity, the immunity back was got blood on the 4th day, separation of serum, with 100 times of normal saline dilutions, get dilution back serum 1ml and 5% chicken erythrocyte suspension 0.5ml, 10% complement 0.5ml is blended in 37 ℃ of water-baths and acts on 30 minutes, stopped reaction in 0 ℃ of refrigerator, the centrifuging and taking supernatant is in 721 spectrophotometer 540nm place colorimetrics, measure optical density (OD value), and establish the not blank of increase serum, and transferring " 0 " benchmark when getting its supernatant and making colorimetric, the result is as follows:

Group number of animals dosage OD value P ^*Compare with normal saline

(only) (ml/20g) heavy dose of 10 0.16 0.88 ± 0.36＞0.05 The above results of low dose of 11 0.08 0.79 ± 0.08＜0.05 anticarcinogen of X ± S normal saline 11 0.1 0.66 ± 0.20 Radix Astragali 11 0.2 0.79 ± 0.1＜0.05 anticarcinogen shows: anti-lung-cancer medicament can increase mice serum hemolysin (IgM) content, illustrates that anti-lung-cancer medicament has the ability that improves mouse humoral immune.* significance test adopts the check of t ' principle.

Three. to the influence of abdomen shin macrophage function: (Suzhou Medical College) method of inspection: with reference to method (the Science and Technology of Shanghai publishing house of 158 pages of Li Yikui chief editor herbal pharmacology experimental methodology.1991) assay: selecting body weight is 60 of the healthy Kunming mouses of 18--22g, be divided into 6 groups at random, according to the form below grouping administration respectively, irritate stomach once for every, continuous 15 days, after the last administration 24 hours, every Mus abdomen shin is injected the coccus suspension 0.5ml of lemon yellow grape Portugal (900,000,000/ml), put to death mice with cervical vertebra Tuo Baifa after 1 hour, the mouse web portion of abdomen shin injecting normal saline 2ml, and massage is immediately drawn 0.5ml abdomen shin drop sheet, Ji Shi method dyed oil sem observation the results are shown in following table: group number of animals dosage phagocytic percentage phagocytic index

(only) be ((negative control (0.9%N.S) 10 0.1 25.9 ± 13.8 1.24 ± 0.71 positive controls (Radix Astragali) 10 0.2 400 ± 15.5 of X ± SE) of X ± SE) (ml/20g) ^*3.52 ± 0.91 ^*Anticarcinogen low dose of 10 0.08 34.2 ± 15.0 ^*2.55 ± 0.69 ^*Anticarcinogen heavy dose of 10 0.16 37.0 ± 15.3 ^*2.35 ± 0.74 ^*Compare with negative control ^*P＜0.05 ^*P＜0.01 finds out that by last result anti-lung-cancer medicament can obviously improve mouse macrophage phagocytic percentage and phagocytic index, illustrates that anti-lung-cancer medicament can activate the phagocytic function of mice abdomen shin macrophage.

Four. measure mice serum IgG level relatively: (Suzhou Medical College) method of inspection: should lovelyly wait with reference to leaf and edit the clinical experiment diagnostics, the P1600 assay: tested serum is through quantitatively being added in behind the doubling dilution on the agar slide that has prepared, carry out double immunodiffusion test with anti-mouse IgG antibody, its result is as follows:

It's 1: 40 is past frequency serum dilution group 1: 80 1: 160 1: 320 1: 640 G ± S.D T ^*P lung ball small dose group 4411 150 ± 1.99 5.8＜0.05 heavy dose of group of lung ball 64 105 ± 1.43 3.27＞0.05 positive controls that disappear that disappear, (Radix Astragali) 631 113 ± 1.63 3.5＞0.05 negative controls, (normal saline) 181 80 ± 1.38 result of the tests show: the anti-lung-cancer medicament small dose group can improve mice IgG level. ^*T value is each group and negative control fiducial value.

Five. lymphocyte transformation test: (Suzhou Medical College) method of inspection: with reference to Li Yikui chief editor's herbal pharmacology experimental methodology (Science and Technology of Shanghai publishing house, 1991, P164) assay: get 60 of 18--22g healthy mices, be divided into 6 groups at random, difference intramuscular injection every day PHA10mg/Kg, totally three days, in injection according to the form below the previous day grouping administration, irritate stomach every day once, totally seven days, tail vein blood smear behind 24 hours of last administration, end Albert'stain Albert, oily mirror be the percentage rate of lymphoblast and transition cell in 100 lymphocytes of counting down.Result such as following table: sample title number of animals (only) dosage (ml/20g) lymphoblast (%) transition state cell (%) normal saline 10 0.1 18.2 ± 4.8 27.9 ± 4.6 Radixs Astragali 10 0.2 29.5 ± 15.1 ^*38.2 ± 11.7 ^*Medicine low dose of 10 0.08 22.3 ± 5.4 41.4 ± 6.9 ^*Medicine heavy dose of 10 0.16 33.9 ± 6.6 ^*28.9 ± 7.0 compare with the normal saline group ^*P＜0.05 ^*P＜0.01 result shows: anti-pulmonary carcinoma medicine can make mice that the conversion reaction that PHA stimulates is strengthened, and can improve the lymphocytic responsibility of T, can improve the function of mouse cell immunity.

Six. acute toxicity test report: (Suzhou Medical College) experiment material: anti-lung-cancer medicament liquid, every milliliter is equivalent to contain crude drug 1 gram, is provided by horizontal pool tumour hospital, and Kunming mouse is provided by the breeding of Suzhou Medical College Experimental Animal Center.Experimental technique and result: (20 of the gram mices of X ± SD) of getting body weight and be 21.0 ± 0.9, male and female half and half, every Mus filling stomach dose is the 1ml/10g body weight in 24 hours, observed 7 days continuously after the administration, mice activity, feed, breathing and defecation etc. all do not have obviously change, do not see that mice has the phenomena of mortality yet, after experiment finishes, the part mice becomes celestial through execution and finds that the minority mouse liver has silght enlargement, and microscopically is the degeneration of slight cavity sample, and other main organs is not seen has obvious pathologic to change.

T=24 ℃ of observation item of anti-lung-cancer medicament The acute toxicity tests observing time (my god)

1234567 survival number (only) 20 20 20 20 20 20 20 death toll (only) 0000000 calculate that according to above result the oral LD of anti-lung-cancer medicament mice is more than 100 gram/Kg.Conclusion: the oral LD of anti-lung-cancer medicament mice is 18 gram/skies/people as people's consumption more than 100g/Kg, and then LD is more than 30 times of people's usual amounts, belongs to harmless substantially level (Shanghai science tech publishing house publishes for industrial toxicology experimental technique, P10,1977).

The invention will be further described below in conjunction with embodiment:

Embodiment: a kind of anti-lung-cancer medicament, wherein the part by weight of each composition is:

(1) Cordyceps 8 grams;

(2) Placenta Hominis 8 grams;

(3) Radix Stemonae 9 grams;

(4) Bulbus Lilii 9 grams;

(5) Radix Glycyrrhizae 6 grams;

(6) Radix Astragali 20 grams;

(7) Radix Scutellariae 8 grams;

(8) Radix Asparagi 12 grams;

(9) restrain Radix Ophiopogonis 12;

(10) Radix Platycodonis 8 grams.With behind various Chinese medicine ingredients mixing, the pulverization, make pill in the such scheme, also can make liquor even injection.

The 100 routine clinical observations of anti-lung-cancer medicament treatment advanced lung cancer:

Modern medicine thinks that the pulmonary carcinoma overwhelming majority rises in bronchus person and sees at most from the bronchial mucosa epithelium, can be divided into three types according to position, place and growth pattern:

1. central type carcinoma of lung betides main bronchus, and leaf bronchus or segmental bronchus person are maximum.

2. peripheral type carcinoma of lung is the independent tuberosity in the pulmonary parenchyma.

3. special type pulmonary carcinoma can show as pancoast tumor, foxtail millet grain type pulmonary carcinoma, pneumonia type pulmonary carcinoma, mediastinum type pulmonary carcinoma, pleura type pulmonary carcinoma and stability pulmonary carcinoma etc.

Pathology is knitted form and is divided into squamous cell carcinoma, and adenocarcinoma has alveolar ramuscule pipe cancer only for seldom seeing.

Clinical data:

1. case is originated: this group pulmonary carcinosis is per capita through various big hospital (1) X film making (2) CT (3) bronchoscope (4) expectorant smear, look for suspicious lymph node biopsy of exfoliative cyte (5) cervical region and the inspection of scalenus anterior fatty tissue and cytological examination of hydrothorax all to can be used as diagnosis basis in the expectorant, all clarify a diagnosis and classify the clinical observation object through the side of screening as.

2. clinical observation 100 routine pulmonary carcinoma objects: modern medicine mainly adopts operation, radiotherapy, three kinds of methods treatments of chemotherapy to primary disease, lose surgical condition during this organizes in the 100 routine advanced lung cancers of clinical observation mostly, patient age is bigger, physical weakness, can not accept chemotherapy, other recurs after having the patient to undergo surgery, or changes property pulmonary carcinoma etc. because of doing certain another kind of tumor resection.

3. this case age:

Table one: age-sex woman's (example) man (example) amounts to (example) 71 years old, and--------50 years old 45 831 years old--40 years old 33 614 years old 11 from showing 60 years old at a glance--sickness rate was higher in 70 years old in 60 years old 4 16 2041 years old in 70 years old 6 28 3451 years old in 81 years old 79 1661 years old, minimum friend 4 years old, maximum 80 years old.

4. find out from table one that in visible male patient's 68 examples, what the male fell ill pulmonary carcinoma is higher, it is to shift behind the breast tumor operation that 11 examples are arranged in female lung cancer 32 examples.

Table two:

Man's (example) woman (example)

68 32

5. table three:

Office rank worker peasant student

Several 39 examples, 31 examples, 1 examples of example find out that from table three that lung cancer morbidity is higher is the worker, and the student is inferior.

6. the course of disease: patients with lung cancer maximum duration 11 months, the shortest time is 2 months.

7. symptom and Signs: this group case all has typically to choke coughs, and mostly is the paroxysmal irritative cough, and sputum mixed with blood is more than, chest and back pain, uncomfortable in chest out of breath, the cyanosis of the face and lips of breathing hard with heating, has ecchymosis more on the tongue, the hydrothorax difficulty disappears, emaciated physique, general weakness, dry mouth and throat, constipation with dry stool, yellowish or reddish urine, puffiness of face can not be put down for sleeping in, poor appetite is felt sick sometimes, vomiting, dysphoria with feverish sensation in the chest palms and soles, night sweat, thready and rapid pulse or deep,thready and rapid pulse.

8. pulmonary carcinoma is clinical, typing and therapeutic scheme:

Pulmonary carcinoma accept Chinese traditional treatment must typing could determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs:

Table four:

Classification therapy scheme type of deficiency of both QI and YIN supplementing QI and nourishing YIN, heat-clearing and toxic substances removing, softening and eliminating sputum.The YIN-deficiency type nourishing YIN and moistening the lung, the dispersing tumor eliminating stagnation.The deficiency of yang type warming and recuperating the spleen and kidney, blood circulation promoting and blood stasis dispelling, dehumidifying cold expelling.Former pulmonary carcinoma regulating QI and promoting blood circulation to remove blood stasis, the softening the hard mass detoxifcation, the collateral dredging that eliminates the phlegm, strong water clearing heat in the lung, supplementing QI and nourishing YIN,

Heat-clearing and toxic substances removing, purging fire and cooling blood.Transitivity pulmonary carcinoma Comprehensive Treatment.The cough-relieving of lung stagnated phlegm knot blood lung, dissipating phlegm and resolving masses.The clearing heat and moistening lung of deficiency of the lung phlegm-heat type, preventing phlegm from forming and stopping coughing.

Find out that from table pulmonary carcinoma is that whole body belongs to void, local true disease, void are bases of disease, real is the mark of disease, helps this therapeutic scheme, with regulating the flow of QI to dissipate blood stasis, hard masses softening and resolving, removing heat-phlegm, the partial realities of Drug therapy such as cough-relieving detoxifcation are with benefiting QI and nourishing blood, strengthening the spleen and tonifying the lung, tonify deficiency such as improving inspiration by invigorating the kidney are marked and are originally taken into account to show consideration for the void of body, and strengthening vital QI to eliminate pathogenic factors is wanted rational use of drug.

9. determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs: according to the differentiation of tcm Clinical typing, main symptom, picture of the tongue, pulse condition, utilization four diagnostic methods people guiding principle, clinical with instruction of Chinese Medicine theory, necessarily accomplish to suit the remedy to the case, in a word, be according to strengthening vital QI to eliminate pathogenic factors and reinforcement and elimination in combination, the giving consideration to both the incidental and fundamental therapeutic scheme.

10. clinical observation on the therapeutic effect:

(1) criterion of therapeutical effect: central authorities in 1972 " about treatment by Chinese herbs cancer criterion of therapeutical effect notice ", this group case is divided produce effects, effective, invalid three kinds.

Produce effects: symptom disappears substantially, and the carninomatosis kitchen range dwindles over half, and other objective determination takes an evident turn for the better.I level regulation development person no longer more than half a year; The II level is stipulated 2--6 month no longer development person.

Effectively: the symptom focus that makes moderate progress is basicly stable, regulation person more than month.

Invalid: symptom and objective determination do not have to improve or have short-term to improve rapid deterioration person again.

(2) efficacy result: pulmonary carcinoma 100 examples are through the clothes anti-lung-cancer medicament, and after receiving treatment, particularly pain takes a turn for the better, and the sputum mixed with blood bottle is few, 28 routine pulmonary carcinoma symptoms of produce effects, and basic the disappearance, sick body dwindles more than half arrives.

Effective 50 routine pulmonary carcinoma symptoms make moderate progress, and focus is made film by X, and CT is development not.

Focus is basicly stable, total effective percentage 80%.

Table six:

The course of treatment, from table six as seen produce effects enabledisable 4+,2=6 9 14 9 the 3rd course of treatment of 13 30 6 second courses of treatment, first course of treatment 67 added up to 28 50 22, be the basic course of treatment of observe the curative effect first course of treatment, and curative effect is also apparent in view.Two, three courses of treatment, curative effect also showed better in order to consolidate the course of treatment.

11. lab testing: the patient obeys anti-lung-cancer medicament, by looking into liver function, hematuria, stool routine examination inspection, does not all find special variation, does not more have untoward reaction, does not spit blood, and pain is not vomitted, and does not generate heat, and also has therapeutical effect if any above-mentioned symptom.

12. model case:

Just prosperous male 62 years old of the Yin Dynasty, Zhang Dian township, Taixing City, Jiangsu Province peasant, the cough spitting of blood appearred in the patient at the beginning of 90 years 6 months, symptoms such as the heat that occurs together headache, June 11 and June 12 days respectively in Tai County Zhang Dian commune hospital and the X of Taizhou City the People's Hospital line film making inspection be diagnosed as lower-left pulmonary carcinoma companion obliterative inflammation, accepted treatment by Chinese herbs on June 27, medication after 10 days subjective symptoms be clearly better, continue to treat to July 30, take the photograph sheet check at former inspection unit X line, with June 11 sheet compare the complete obiteration of lower-left agglomerate shadow, clinical cure, alive so far.

Shen Fasheng man 67 years old, Wu County, Jiangsu retired employees of shipping company, patient's cough, chest pain is surplus February, live the treatment hospitalized to have a thorough examination of the People's Hospital, Wu County in July, 91, admission number 1633 is made film through the X line, inspections such as CT are diagnosed as bottom right pulmonary carcinoma, May 4, change No.1 Hospital Attached to Suzhou Medical College and further check treatment,, make film through X--RAY again etc. through the ECG lung function tests, diagnosis is with preceding identical, desire with its radiotherapy but family members and disagree with in person and leave hospital that i.e. treatment by Chinese herbs was treated month, check on July 21, full rabat prompting has big lung lamellar shade to disappear more substantially with former, and the improvement of patient's subjective symptoms is uncomfortable in chest, alleviation out of breath (original emphysema disappearance), appetite, it is all good to sleep, clinical cure.

Claims (3)

1. anti-lung-cancer medicament, its composition comprises (1) Cordyceps, (2) Placenta Hominis, (3) Radix Stemonae, (4) Bulbus Lilii, (5) Radix Glycyrrhizae.

2. anti-lung-cancer medicament according to claim 1 is characterized in that: its composition also comprises (6) Radix Astragali, (7) Radix Scutellariae, (8) Radix Asparagi, (9) Radix Ophiopogonis, (10) Radix Platycodonis.

3. according to claim 1 and 2 described anti-lung-cancer medicaments, it is characterized in that: the part by weight of described each composition is:

(1) Cordyceps 5--10 gram;

(2) Placenta Hominis 5--10 gram;

(3) Radix Stemonae 5--12 gram;

(4) Bulbus Lilii 6--12 gram;

(5) Radix Glycyrrhizae 2--9 gram;

(6) Radix Astragali 10--30 gram;

(7) Radix Scutellariae 6--12 gram;

(8) Radix Asparagi 10--15 gram;

(9) Radix Ophiopogonis, 10--15 restrained;

(10) Radix Platycodonis 6--12 gram.