CN122182027A - 基于nad(p)-依赖酶的传感器的nad(p)储库 - Google Patents

基于nad(p)-依赖酶的传感器的nad(p)储库

Info

Publication number
CN122182027A
CN122182027A CN202610289340.3A CN202610289340A CN122182027A CN 122182027 A CN122182027 A CN 122182027A CN 202610289340 A CN202610289340 A CN 202610289340A CN 122182027 A CN122182027 A CN 122182027A
Authority
CN
China
Prior art keywords
sensor
analyte
nad
certain embodiments
active region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202610289340.3A
Other languages
English (en)
Chinese (zh)
Inventor
T·欧阳
C·福克斯
刘增何
S·奥贾
B·J·弗尔德曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Diabetes Care Inc
Original Assignee
Abbott Diabetes Care Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Diabetes Care Inc filed Critical Abbott Diabetes Care Inc
Publication of CN122182027A publication Critical patent/CN122182027A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0022—Monitoring a patient using a global network, e.g. telephone networks, internet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/008—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions for determining co-enzymes or co-factors, e.g. NAD, ATP
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/0103—3-Hydroxybutyrate dehydrogenase (1.1.1.30)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y112/00—Oxidoreductases acting on hydrogen as donor (1.12)
    • C12Y112/01—Oxidoreductases acting on hydrogen as donor (1.12) with NAD+ or NADP+ as acceptor (1.12.1)
    • C12Y112/01002—Hydrogen dehydrogenase (1.12.1.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202610289340.3A 2020-12-15 2021-12-15 基于nad(p)-依赖酶的传感器的nad(p)储库 Pending CN122182027A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063125846P 2020-12-15 2020-12-15
US63/125,846 2020-12-15
PCT/US2021/063600 WO2022132963A1 (en) 2020-12-15 2021-12-15 Nad(p) depot for nad(p)-dependent enzyme-based sensors
CN202180084707.3A CN116648191B (zh) 2020-12-15 2021-12-15 基于nad(p)-依赖酶的传感器的nad(p)储库

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202180084707.3A Division CN116648191B (zh) 2020-12-15 2021-12-15 基于nad(p)-依赖酶的传感器的nad(p)储库

Publications (1)

Publication Number Publication Date
CN122182027A true CN122182027A (zh) 2026-06-12

Family

ID=81183509

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202610289340.3A Pending CN122182027A (zh) 2020-12-15 2021-12-15 基于nad(p)-依赖酶的传感器的nad(p)储库
CN202180084707.3A Active CN116648191B (zh) 2020-12-15 2021-12-15 基于nad(p)-依赖酶的传感器的nad(p)储库

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202180084707.3A Active CN116648191B (zh) 2020-12-15 2021-12-15 基于nad(p)-依赖酶的传感器的nad(p)储库

Country Status (7)

Country Link
US (2) US12404535B2 (cg-RX-API-DMAC7.html)
EP (2) EP4714348A1 (cg-RX-API-DMAC7.html)
JP (2) JP7766691B2 (cg-RX-API-DMAC7.html)
CN (2) CN122182027A (cg-RX-API-DMAC7.html)
AU (2) AU2021400588B2 (cg-RX-API-DMAC7.html)
CA (1) CA3200244A1 (cg-RX-API-DMAC7.html)
WO (1) WO2022132963A1 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4780327A2 (en) 2023-09-22 2026-07-29 Abbott Diabetes Care Inc. Decision support for glucose-ketone sensor
EP4788223A1 (en) * 2023-10-04 2026-08-12 Abbott Diabetes Care Inc. Stabilization of nad(p)-dependent sensor with negatively charged membrane
WO2025224173A1 (en) 2024-04-23 2025-10-30 Directsens Gmbh Enzymatic assessment of glucose metabolic disorders
WO2025245355A1 (en) 2024-05-24 2025-11-27 Abbott Diabetes Care Inc. Dispensed area and drop solid content tunability
CN119224087A (zh) * 2024-09-30 2024-12-31 深圳津合生物有限公司 一种用于葡萄糖检测的酶电极、传感器及其应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9623149D0 (en) * 1996-11-07 1997-01-08 Univ Manchester Sensor
US5801006A (en) 1997-02-04 1998-09-01 Specialty Assays, Inc. Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites
US6736957B1 (en) 1997-10-16 2004-05-18 Abbott Laboratories Biosensor electrode mediators for regeneration of cofactors and process for using
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US8268143B2 (en) 1999-11-15 2012-09-18 Abbott Diabetes Care Inc. Oxygen-effect free analyte sensor
US6605201B1 (en) 1999-11-15 2003-08-12 Therasense, Inc. Transition metal complexes with bidentate ligand having an imidazole ring and sensor constructed therewith
US8444834B2 (en) 1999-11-15 2013-05-21 Abbott Diabetes Care Inc. Redox polymers for use in analyte monitoring
US6932894B2 (en) 2001-05-15 2005-08-23 Therasense, Inc. Biosensor membranes composed of polymers containing heterocyclic nitrogens
DE10246303A1 (de) * 2001-09-29 2003-05-08 Biotechnologie 3000 Gmbh System als Referenzelektrode, als amperometrisches, potenziometrisches, biosensorisches Messsystem oder als elektrochemisches Synthesesystem mit verlängerter Lebensdauer
DE10221435B4 (de) 2002-05-14 2004-10-28 Isabella Dr. Moser Enzymelektrodenanordnung, ein Verfahren zu deren Herstellung sowie eine diese Enzymelektrodenanordnung umfassende Biosensoranordnung
US7501053B2 (en) 2002-10-23 2009-03-10 Abbott Laboratories Biosensor having improved hematocrit and oxygen biases
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
DE102005035461A1 (de) 2005-07-28 2007-02-15 Roche Diagnostics Gmbh Stabile NAD/NADH-Derivate
BRPI0717430A2 (pt) 2006-09-22 2013-11-12 Bayer Healthcare Llc Sistema de biossensor tendo estabilidade e desempenho de hematócritos maiores
US8636884B2 (en) 2008-09-15 2014-01-28 Abbott Diabetes Care Inc. Cationic polymer based wired enzyme formulations for use in analyte sensors
FI3714788T3 (fi) 2009-02-26 2023-04-25 Abbott Diabetes Care Inc Parannettujen analyyttisensorien valmistusmenetelmä
MX2012008427A (es) 2010-01-22 2012-08-15 Bayer Healthcare Llc Desecantes mejoradores de la exactitud.
ES2592175T3 (es) * 2010-08-24 2016-11-28 Microchips Biotech, Inc. Dispositivo de biodetección implantable y métodos de uso del mismo
DK3831283T3 (da) 2011-12-11 2023-05-30 Abbott Diabetes Care Inc Analytsensorindretninger, forbindelser og fremgangsmåder
DK2679156T3 (da) * 2012-06-28 2019-12-02 Hoffmann La Roche Anordning til monitorering af mindst én kropsfunktion hos en bruger og fremgangsmåde til fremstilling heraf
WO2014099907A1 (en) 2012-12-18 2014-06-26 Abbott Diabetes Care Inc. Dermal layer analyte sensing devices and methods
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
EP4325222A3 (en) * 2016-03-04 2024-05-01 Abbott Diabetes Care Inc. Nad(p)-dependent responsive enzymes, electrodes and sensors, and methods for making and using the same
RU2629796C1 (ru) * 2016-05-23 2017-09-04 Общество с ограниченной ответственностью "Лаборатория межклеточных технологий "Интерсел Рэнд" (ООО "Интерсел Рэнд") Способ и мультисенсорное устройство для неинвазивного мониторинга уровня глюкозы в крови
EP3570735A4 (en) 2017-01-23 2020-10-21 Abbott Diabetes Care Inc. SYSTEMS, DEVICES AND METHODS FOR INSERTING ANALYTE SENSOR
EP3641646A1 (en) 2017-06-23 2020-04-29 Percusense Analyte sensor
FI3668400T3 (fi) 2017-08-18 2023-08-29 Abbott Diabetes Care Inc Menetelmä analyyttianturien yksilölliseen kalibrointiin
US20210236028A1 (en) 2018-05-17 2021-08-05 Abbott Diabetes Care Inc. Analyte sensor antimicrobial configurations and adhesives
DK4218567T3 (da) 2018-06-07 2025-03-31 Abbott Diabetes Care Inc Fokuseret sterilisering og steriliserede underenheder til analytovervågningssystemer
EP4585143A3 (en) 2018-06-07 2025-10-01 Abbott Diabetes Care, Inc. Focused sterilization and sterilized sub-assemblies for analyte monitoring systems
MX2021007294A (es) 2018-12-21 2021-07-15 Abbott Diabetes Care Inc Sistemas, dispositivos y metodos para la insercion de sensores de analito.
AU2020214230B2 (en) * 2019-01-28 2023-03-02 Abbott Diabetes Care Inc. Analyte sensors employing multiple enzymes and methods associated therewith
EP4574038A3 (en) * 2019-01-28 2025-08-27 Abbott Diabetes Care, Inc. Analyte sensors and sensing methods featuring dual detection of glucose and ketones
US12220235B2 (en) * 2019-01-28 2025-02-11 Abbott Diabetes Care Inc. Analyte sensors and sensing methods for dual detection of glucose and ethanol
US20220304599A1 (en) * 2019-08-31 2022-09-29 PercuSense, Inc. Analyte sensor

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Publication number Publication date
EP4714348A1 (en) 2026-03-25
US20240279708A1 (en) 2024-08-22
EP4262557B1 (en) 2026-01-21
AU2025205202A1 (en) 2025-07-24
WO2022132963A1 (en) 2022-06-23
CA3200244A1 (en) 2022-06-23
US12404535B2 (en) 2025-09-02
AU2021400588B2 (en) 2025-04-10
US12649944B2 (en) 2026-06-09
JP2023554367A (ja) 2023-12-27
AU2021400588A1 (en) 2023-06-22
US20220186277A1 (en) 2022-06-16
CN116648191B (zh) 2026-04-10
EP4262557A1 (en) 2023-10-25
JP7766691B2 (ja) 2025-11-10
CN116648191A (zh) 2023-08-25
JP2026016616A (ja) 2026-02-03

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