CN1221620A - Compound medicine for treating diabets mellitus - Google Patents

Abstract

A composite medicine in the form of capsules for curing diabetes is prepared from anisodamine, pollen and rehmannia root and serves to improve microcirculation, eliminate the damage of lipid peroxide to blood vessel and the free radicals and increase the physiological function of SOD. Its advantages are high curative effect and low cost.

Description

The composition of medicine of treatment diabetes

The present invention relates to a kind of compositions of forming by synthetic drug and Chinese herbal medicine that is used for the treatment of diabetes.Be applicable to the other therapies loser.

The medicine of treatment diabetes has three kinds at present, and the one, chemical synthetic drug, though this type of medicine blood sugar lowering is rapid, side effect is big, takes the damage hepatic and renal function especially for a long time, easily causes the complication of diabetes to take place.The 2nd, insulin preparation, type patient, oral antidiabetic drug nonresponder, use the disorderly preparation of islets of langerhans, but the patient have very strong dependency to islets of langerhans, and hypoglycemic reaction is arranged, and the 3rd class is the natural Chinese medicine agent, the energy treating both the principal and secondary aspects of a disease, rare hypoglycemia also can reduce the complication of diabetes, has no side effect, but long-term prescription costs an arm and a leg, and is difficult to economically bear.

The purpose of this invention is to provide a kind of composition of medicine for the treatment of diabetes cheaply.

Technical scheme of the present invention:

The composition of medicine of treatment diabetes is called for short diabetes capsule by three kinds of components, Anisodamine (654-2), pollen, the Radix Rehmanniae.The weight ratio of three kinds of components is: Anisodamine 1-2 part

Pollen 15-30 part

Radix Rehmanniae 15-30 part

The Anisodamine molecular formula:

Pharmacological action: Anisodamine sheet (654-2) has amplitude and the frequency of strengthening arteriolar vasomotion, and activation is in the amplitude and the frequency of the arteriolar vasomotion of inhibitory state, and make its reinforcement improve the cell membrane activity, improve receptor in target cell number adhesion, improve receptor defects, improve the sensitivity of peripheral tissues's (skeletal muscle) to insulin, this function made regional flow clearly redistributes, improve the blood perfusion of histoorgan, eliminate the infringement of lipid peroxide, strengthen the physiological function of superoxide dismutase blood vessel, nerve.When suitable physical training or work, make glucose carry out aerobic metabolism, reach blood sugar lowering to normal purpose, prevent the generation of complication.

Pollen: Main Ingredients and Appearance is for containing pollen protein several amino acids, Saponin.

Pharmacological action: analgesic moisturizing, promoting the production of body fluid to quench thirst.

Cure mainly: consumption of body fluid caused by febrile disease is thirsty, laryngopharynx swelling and pain.

The Radix Rehmanniae: contain rehmanin, catalpol several amino acids.

Pharmacological action: the heart tonifying diuresis, blood sugar lowering is used for the treatment of fever due to yin deficiency, excessive thirst.

Further specify below in conjunction with clinical case.

Clinical experiment report 100 examples:

In February, 1988-1988 year October,, now be reported as follows with diabetes capsule treatment diabetes 100 examples:

Physical data:

100 routine diabeticss all meet The World Health Organization's standard, i.e. fasting glucose 〉=7.78mmol/L (140mg/d), male 56 examples, woman's 44 examples, the oldest 72 years old, minimum 18 years old, the course of disease one month-20 years, type 100 examples, wherein 2 examples are treated with the islets of langerhans rope, 38 examples were once used glyburide, metformin, diabetes pill, reach the enzyme health, the husky sheet of enlightening, islets of langerhans hypertrophy ball, back glycemic control is undesirable or invalid.

Complication: hypertension 29 examples, coronary heart disease 4 examples, cerebral infarction 3 examples, peripheral neuritis 9 examples, arrhythmia 2 examples, cataract 1 example, chronic asthmatic bronchitis, brain blood is fastened 1 example.

Therapeutic Method: after diagnosis is clear and definite, assist the patient to set up daily life system clocklike, suitably, can reduce the burden of cell from keeping a diet, even more important to the overweight people, carry out and strike a proper balance between work and rest, note Personal hygiene, prevent various infection, participate in suitable physical training, recreational activities, muscle power are moving always, are beneficial to promote the reasonable utilization of sugar.Concrete grammar is as described below.

The insulin-dependent diabetics, when using insulin, pay close attention to blood glucose, glucose in urine, glycosylated hemoglobin, when detecting islet function, can reduce insulin dosage gradually when using diabetes capsule, stop using at last, use diabetes capsule instead and take for a long time and keep periodic review.

Attention: in observing treatment, survey glucose in urine 1-4 every day, before the meal half an hour glucose in urine, empty stomach is had a blood test sugar once weekly.

Usage, consumption: composition of medicine is developed into capsule, and every capsules contains Anisodamine 5mg, Radix Rehmanniae 0.1g, pollen 0.1g.First according to individual concrete condition from each 1, three beginnings every day, increase progressively 1 every day later at every turn, reach 654-2, behind the 2-2.5mg/kg/d, every chemical examination blood glucose, glucose in urine once, around keeping, this has chemical examination blood glucose therebetween twice, glucose in urine is normal, then begins decrement gradually, the 15mg that successively decreases every day (3), reduce at last early, in respectively obey 3 after meal, evening, taking medicine after meal was 4, and every day, total amount 50mg took for a long time, 13 weeks were a course of treatment, the nonresponder can carry out second course of therapy, presses 3.0mg/kg/d by the treatment of top method, as the invalid interchangeable insulin treatment of above-mentioned method or other therapies.

Such as 60 kilograms of patients: total amount is 120mg/ day, and concrete grammar is as follows:

Evening at noon morning

First day 111

Second day 222

The 3333

The 4th day 444

The 5th day 555

The 6th day 666

The 7th day 777

The 8th day 888

Before reaching total amount, can take diamicron, since 80 milligrams, once a day according to blood glucose, glucose in urine situation, but after diabetes capsule reaches total amount, withdraw all hypoglycemic medicines, take diabetes capsule separately, if after two weeks, twice chemical examination blood glucose, glucose in urine is normal, successively decrease each 1 gradually from total amount again, subtract 3 every day, as 24 of total amount every days, each 8, then successively decrease each 7,6,5,4,3,2 according to the order of sequence, or early 3, in 4 of 3, evening, take periodic review for a long time.Control is undesirable if blood glucose, glucose in urine descend, can still continue to take a course of treatment by this side, dosage can calculate by 3 milligrams/kilogram/daily dose, general most of people's blood glucose, glucose in urine all reach normal, but often recover undesirable after the diabetes patient is influenced by stressors, but must be confident of, adhere to taking medicine, reach ideal state at last.

Efficacy determination, by The World Health Organization's standard, fasting glucose 7.78mmol/L, it is white to look into saccharifying blood count red eggs continuously, and check in per 2～3 months is once.

Diabetes control criterion vein blood glucose is satisfied well still can be relatively poor

mmol/L ＜6.11 6.11-7.77 7.77-9.99 ＞9.99

Mg/g＜110 110-140 140-180＞180 are blood glucose＜7.77 7.77-11.10 11.10-12.77＞12.77 after meal

＜140 140-200 200-230＞blood red egg 4-6 of 230 saccharifying 6-8 8-10＞10

Glucose in urine 00 0.5＞2.8

T-CHOL mmg/L＜5.2 5.2-6.5＞6.5

Mg/d＜200 200-250＞250 triglyceride mmol/L＜1.70 1.70-2.26＞2.26

mg/d ＜1?50 150-200 ＞200

Blood pressure KPa≤18.7 18.7-21.3/12.0-12.7＞21.3/12.7

≤140/90 140-160/90-95 ＞160/95

HbL cholesterol＞1.0 0.91-1.0＜0.91

＞40 35-40 ＜35

The time that curative effect occurs: 1 all 4 examples, 2 all 12 examples, 3 all 35 examples, 4 all 42 examples, 5 all 2 examples, invalid 2 examples, total effective rate is 95%.

The doing well,improving time: polydipsia, eat symptom 10 days more and improve, 1 week of polyuria symptom improves, and the hyperhidrosis symptom was improved in 3 days, and weak 2 weeks of symptom improve, and all itching over the body symptoms were improved in 7 days, and whole body myalgia symptom was improved in 10 days.

Points for attention: glaucoma forbidding, cerebral hemorrhage forbidding.

Side effect: xerostomia, dim eyesight, the abdomen account, urination time prolongs, and above-mentioned symptom is many to disappear in 4 weeks, the xerostomia person rope C that can orally support one's family, each 400 milligrams, every day three times, the oral dysuria that prevents, the preceding emptying bladder of can urinating.

Know from experience: diabetes are that multiple reason causes the disease that causes from the endocrine disturbance, and type insulin cell function is normal mostly, and it mainly is that Insulin receptor INSR sensitivity reduces and receptor defects.

Internal diameter day: sun outside its for making also, cloudy interior its for keeping also, make function for it, keep material for it, function is finished on material base.

The function that each organ of body is had nothing in common with each other is kept the metabolism of collective.How to improve the sensitivity of receptor in target cell number adhesion and insulin? how to supply with the material base of insulin cell excreting insulin, make it to remove the conflict state of insulin?

With the perfect above-mentioned difficult point of solution of diabetes capsule energy.Diabetes capsule includes mountain henbane Liang alkali, she can strengthen the amplitude and the frequency of arteriolar vasomotion, and can activate the arteriolar spontaneous vasomotion amplitude and the frequency that are in inhibitory state and strengthen, improve the cell membrane activity, improve the resistance state of islets of langerhans, show that mainly peripheral tissues's (mainly being skeletal muscle) is insensitive to islets of langerhans, sugar utilization is suppressed, if take pollen is arranged in the diabetes capsule, contains several amino acids, have analgesic moisturizing, the promoting the production of body fluid to quench thirst function.The Radix Rehmanniae can be treated excessive thirst by nourishing YIN and clearing away heat, can also blood sugar lowering.When using diabetes capsule; suitable participation physical training or work; make glucose carry out aerobic metabolism; protected hepatic and renal function; prevent the generation of complication; the blood that contains HbO2 Oxyhemoglobin fully is active in the microcirculation; be not difficult to improve the sensitivity of islets of langerhans target cell; the islet cells secretory function is subjected to neurohumoral domination; can regional flow be redistributed with diabetes capsule, change the blood flow and the perfusion of histoorgan, eliminate lipid peroxide dismutase SOD physiological function; all medicines share, and make blood sugar recovery to normal level thereby reach.

Claims (2)

1, a kind of composition of medicine for the treatment of diabetes, it is characterized in that: this medicine is made of following component, Anisodamine, pollen, the Radix Rehmanniae.

2, a kind of composition of medicine for the treatment of diabetes according to claim 1, it is characterized in that: the weight ratio of each component is: Anisodamine 1-2 part

Pollen 15-30 part

Radix Rehmanniae 15-30 part