CN1213853C - Non-polyvinyl chloride compound film material for package of intravenous medicine - Google Patents
Non-polyvinyl chloride compound film material for package of intravenous medicine Download PDFInfo
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- CN1213853C CN1213853C CN 01111112 CN01111112A CN1213853C CN 1213853 C CN1213853 C CN 1213853C CN 01111112 CN01111112 CN 01111112 CN 01111112 A CN01111112 A CN 01111112A CN 1213853 C CN1213853 C CN 1213853C
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Abstract
The present invention relates to a multi-layer composite film material which mainly comprises a separating layer, an adhesive layer, a soft layer, an internal layer and external layer. The structure of the multi-layer composite film material can be designed into four layers, five layers and seven layers which are respectively made of non-PVC materials. The composition of the multi-layer composite film material is one or the mixture of polyamide resin, modified polypropylene resin metallocene plastomer and copolypropylene. The multi-layer composite film material accords with all chemical performance and biological performance indexes of liquid medicine packaging materials for intravenous transfusion and is a replacement product for PVC packaging materials. The present invention also relates to the application of the multi-layer composite film material in the liquid medicine packaging materials for intravenous transfusion.
Description
The present invention relates to a class multilayer complex films material, it mainly comprises barrier layer, adhesive layer, soft layer and ectonexine, the structure of this class compound film material is designed to four layers, five layers and seven layers, each rete is non-PVC material, and its composition is separately polyamide, modified polypropylene resin metallocene-plastomer, COPP or their mixture.The invention still further relates to the application of described multilayer complex films material in venous transfusion usefulness medicinal liquid packaging material.
The infusion solutions packaging material that more generally use were flexible PVC (PVC) in the past, because PVC will add various auxiliary agents in the course of processing, micromolecule auxiliary agent migration and PVC self with the chlorine element make it from being worked into removal process, all can discharge harmful components, be detrimental to health.According to environmental protection requirement, be devoted to limit or forbid the use of PVC in recent years in the world, the application of the progressively superseded PVC material of developed country such as Europe, the United States, day on the medicinal liquid packing begins to develop non-PVC-soft packing transfusion material since the nineties.
Because the performance to the medicinal liquid packaging material has many-sided multi-level strict demand, single plastic sheeting can not meet the demands, and composite membrane is that several different monofilms are bonded together by certain processing method, and double advantage of getting various monofilms remedies the deficiency of single thin film.In the requirement of satisfying the every performance indications of chemistry and biology, also must have following performance as the medicinal liquid packaging material: enough mechanical strengths, good clear performance, high temperature high voltage resistant antiseptic property (121 ℃, 1kg/cm
2Pressure, 20 minutes), the gas barrier properties of gases such as good obstruct steam, oxygen, carbon dioxide, guarantee that medicinal liquid never degenerates in the shelf-life, be convenient to the infusion solutions transportation and use.The film material also needs certain flexibility in addition, can avoid air admission to pollute medicinal liquid according to medicinal liquid self gravitation effect emptying medicinal liquid.
At US 4467003, introduced a kind of composite membrane that is used for the medicinal liquid packing among the US 4326574, it is a three-decker: the PP/PA/ ethylene-butene copolymer.
In European patent EP 0802046 A2, a kind of five-layer structure composite membrane that is used for the medicinal liquid packing is disclosed, its innermost layer E is COPP and elastomeric mixture, the D layer is an ethylene-alpha-olefin copolymer, and as the adhesive layer of C and E, the C layer can be any one among VLDPE, LLDPE, EVA, EMA, the HDPE, or their blend, the B layer is an adhesive layer, and used resin is anhydride modified EVA, anhydride modified EMA, anhydride modified PE, and the A layer is PA or PET.
More than several multilayer complex films all have weak point, five layers of composite membrane flexibility in the United States Patent (USP) are bad.The flexibility of five layers of composite membrane in the European patent is relatively good, but that heat resistance has is poor
The objective of the invention is to develop a kind of transparent, soft, can stand high temperature and high pressure steam disinfectant infusion solutions packaging non-PVC composite membrane material, to overcome the shortcoming and the problem of vial transfusion, PVC soft-packing transfusion and other multilayer complex films soft-packing transfusion.
To achieve these goals, the present invention provides a class multilayer complex films material thus, it mainly comprises barrier layer, adhesive layer, soft layer and ectonexine, the structure of this class compound film material is designed to four layers, five layers and seven layers, they all are based on identical design philosophy, thereby it provides corresponding performance to reach good overall performance respectively by each monolayer in the composite bed, each rete is non-PVC material, and its composition is separately polyamide, modified polypropylene resin metallocene-plastomer, COPP or their mixture.Wherein seven layers of compound film materials composition are: (a) intermediate layer 4 is barrier layers, and used resin is a polyamide; (b) both sides of barrier layer are adhesive layer 3 and 5, and its composition is anhydride modified acrylic resin; (c) outside of next-door neighbour's adhesive layer 3 is layers 2, and the outside of next-door neighbour's adhesive layer 5 is layers 6, and layer 2 is the identical symmetrical structures of prescription with layer 6, and composition is metallocene-plastomer and polyacrylic blend; (d) outermost layer 1 is virgin pp or metallocene-plastomer and polyacrylic blend; (e) innermost layer 7 is blends of metallocene-plastomer and COPP.This compound film material has favorable mechanical performance, barrier property, the transparency, flexibility, 121 ℃ of high temperature and high pressure steam sterilizations of ability, and meet every chemical property and the biology performance index of venous transfusion with the medicinal liquid packaging material, the ratio of performance to price is significantly better than composite film material of the prior art.Be the regeneration product of PVC packaging material, can be applicable to the packing of infusion solutionses such as normal saline, glucose.Therefore multilayer complex films material of the present invention can be used on venous transfusion with in the medicinal liquid packaging material.
Fig. 1 is seven layers of composite membrane cross-section structure.
Fig. 2 is five layers of composite membrane cross-section structure.
Fig. 3 is four layers of composite membrane cross-section structure.
The processing method that multilayer complex films of the present invention adopts is that the lower blowing water cold type is multi-layer co-extruded or the tape casting is multi-layer co-extruded. Referring now to accompanying drawing, the compound film material of gained is described in detail. As shown in fig. 1, the structure of seven layers of composite membrane is:
(a) intermediate layer 4 is barrier layers, and used resin is polyamide, and is good to gas barrier properties such as oxygen, carbon dioxide, uses the infusion solutions of this composite film packaging to have longer shelf-life and liquid medicine stability than the infusion solutions that PVC packs. With the coextrusion of copolyamide and other resin, its melt flow index should be at 1.0g/10min～6.0g/10min, and thickness range is 20 μ m～40 μ m. Wherein said polyamide can be selected from PA6, PA66, PA6/66, MXA-6 polyamide.
(b) adhesive layer 3 and 5 is acrylic resins of specific acid anhydride modification, binder resin when this resin can be used as polymer coextrusion such as PP, PA, EVOH, the processing temperature scope of this resin is: 250 ℃～300 ℃, melt flow index is: 1.0g/10min～6.0g/10min, the thickness of this layer is: 5 μ m～20 μ m are preferably in 5 μ m～10 μ m.
(c) layer 2 is the identical symmetrical structures of prescription with layer 6, use the metallocene-plastomer modified polypropylene, wherein the weight percentage of metallocene-plastomer is 30%～70%, and metallocene-plastomer is meant with the metallocene to be catalyst, active ethylene of the list of production and alhpa olefin (C
4, C
6Or C
8) copolymer, wherein the content of alhpa olefin is: 20%～30%, density range is: 0.89g/cm
3～0.92g/cm
3, melt flow index is in 1g/10min～5g/10min scope.Plastic body has excellent heat sealability, can reach higher packing degree, polypropylene can be homopolymerization also can be copolymerization, requiring has good chemical stability and biological stability, melt flow index should be between 1.5g/10min～5g/10min.Use the metallocene-plastomer modified polypropylene, can improve polyacrylic heat sealability, warp resistance performance, shock resistance and flexibility greatly, improved polyacrylic low-temperature embrittleness performance.The existing good transparency of blend composition, flexibility and heat sealability have heat resistance preferably again.The thickness of layer 2 and layer 6 is 40 μ m～60 μ m, plays soft layer in whole structure of composite membrane.Wherein, metallocene-plastomer metallocene linear low density polyethylene preferably.
(d) outermost layer 1 is made for polypropylene or with the polypropylene of metallocene-plastomer modified, plastic body and polyacrylic selecting for use with (c), and the weight percentage of metallocene-plastomer is 0%～30%, thickness is 10 μ m～25 μ m.
(e) innermost layer 7 also is metallocene-plastomer and polyacrylic blend composition, because this layer directly contacts with medicinal liquid, needs higher chemistry and biology stability, also lower heat-sealing temperature will be arranged.The weight percentage of metallocene-plastomer is 20%～50%, and thickness is 30 μ m～40 μ m, makes it have good heat sealability with metallocene-plastomer modified low melting point polypropylene as internal layer, has improved bag Production Line speed.
As shown in Figure 1, the structure of seven layers of composite membrane must meet 1/2/3/4/5/6/7 order from outside to inside, and the composite membrane total thickness is 170 μ m～200 μ m.
Seven layers of composite membrane adopt seven-layer co-extrusion downward-blowing water-cooling processing technique, also can adopt seven-layer co-extrusion The tape casting processing technique.
The structural order of these seven layers of composite membranes is that 1/2/3/4/5/6/7 transparent, soft, health, barrier property are good, can sterilize by anti-121 ℃ of high temperature and high pressure steams, physical and mechanical properties, chemical property and biology performance index all meet the requirement of infusion solutions packaging material.
According to the design philosophy of above seven layers of composite membrane, can be designed to five layers of composite membrane similarly.With reference to Fig. 2, five layers of designed structure of composite membrane are:
(1) intermediate layer is a barrier layer, and the barrier layer in this layer and seven layers is basic identical, and thickness is 20 μ m～40 μ m.
(2) be adhesive layer in the both sides of barrier layer, also be same as seven layers of adhesive layer in the composite membrane, thick 5 μ m～20 μ m.
(3) in the both sides of barrier layer be the blend of metallocene-plastomer or metallocene linear low density polyethylene and COPP, two-layer prescription difference, wherein the weight percentage of metallocene-plastomer is 20%～60%, thickness is 30 μ m～100 μ m.
Specifically, the composition of five layers of composite membrane is:
(1) intermediate layer (c) is barrier layer, and barrier resins is selected PA6, PA66, PA6/66, MXA-6 polyamide for use.
(2) both sides of wall are adhesive layers (b) and (d), and binder resin is selected anhydride modified polypropylene for use.
(3) outermost layer (a) is the blend of metallocene-plastomer and COPP.
(4) innermost layer (e) is the blend of metallocene-plastomer and COPP.
In five layers of above-mentioned composite membrane, the melt flow index of the polyamide described in (1) can be in the scope of 1.0g/10min～6.0g/10min, and the thickness range of this layer is 20 μ m～40 μ m.
In five layers of above-mentioned composite membrane, the melt flow index of the binder resin described in (2) can be 1.0g/10min～6.0g/10min, and layer (b) and thickness (c) all are preferably 5 μ m～20 μ m.
In five layers of above-mentioned composite membrane, the weight percentage of metallocene-plastomer is preferably 20%～40% in (3), and outermost layer thickness is preferably 70 μ m～100 μ m.
In five layers of above-mentioned composite membrane, the weight percentage of metallocene-plastomer is preferably 30%～60% in (4), and innermost layer thickness is preferably 30 μ m～70 μ m.
In five layers of above-mentioned composite membrane, metallocene-plastomer preferably is the active ethylene of list of Catalyst Production and the copolymer of alhpa olefin with the metallocene in (4).
In five layers of above-mentioned composite membrane, the preferably low-melting COPP of the described COPP in outermost layer and the innermost layer.
In five layers of above-mentioned composite membrane, be generally to interior putting in order outside it: a/b/c/d/e, its film gross thickness is: 170 μ m～200 μ m.
In five layers of above-mentioned composite membrane, described alhpa olefin is C preferably
4, C
6Or C
8Alhpa olefin.
Five layers of composite membrane adopt five-layer co-squeezing downward-blowing water-cooling processing technique, also can adopt five-layer co-squeezing The tape casting processing technique.Five layers of composite membrane physical and mechanical properties, chemical property and biology performance index all meet the requirement of infusion solutions packaging material, moderate cost.
According to above identical design philosophy, can in like manner be designed to four layers of composite membrane, as shown in Figure 3, wherein
(1) outermost layer A is a barrier layer, and available resin is polyamide or polyester, and wherein said polyamide can be selected from PA6, PA66, PA6/66 and MXA-6 polyamide, and polyester is preferably copolyester, and this layer thickness is 20 μ m～40 μ m.
(2) next-door neighbour's layer A is adhesive layer B, and used binder resin is specific anhydride modified polypropylene, and thickness is 5 μ m～20 μ m.
(3) adjacent with adhesive layer B is the C layer, and this layer is the blend of metallocene-plastomer and COPP, and the weight percentage ratio of metallocene-plastomer is 30%～70%, and thickness is 120 μ m～140 μ m.This layer material is soft, in whole composite membrane as soft layer.
(4) innermost layer D and C are adjacent, this layer adopts the blend of metallocene-plastomer or metallocene linear low density polyethylene and COPP, wherein the weight percentage of metallocene-plastomer ratio is 20%～50%, and this layer thickness is 20 μ m～40 μ m, as hot sealing layer.
In four layers of above-mentioned composite membrane, the melt flow index of the binder resin described in (1) is preferably 1.0g/10min～6.0g/10min, and the thickness of this layer is preferably 5 μ m～20 μ m.
In four layers of above-mentioned composite membrane, (3) weight percentage of (C) layer metallocene-plastomer is preferably 30%～70% in, metallocene-plastomer preferably is the active ethylene of list of Catalyst Production and the copolymer of alhpa olefin with the metallocene, wherein the content of alhpa olefin is preferably: 20%～30%, and this layer thickness is preferably 120 μ m～140 μ m.
In four layers of above-mentioned composite membrane, (4) metallocene-plastomer in preferably is the active ethylene of list of Catalyst Production and the copolymer of alhpa olefin with the metallocene, wherein the weight percentage of metallocene-plastomer is 20%～50%, and the D layer thickness is 20 μ m～40 μ m.
And in four layers of above-mentioned composite membrane, its order from outside to inside is: A/B/C/D, the total thickness of four layers of composite membrane are 170 μ m～200 μ m.
In addition, in four layers of above-mentioned composite membrane, described alhpa olefin is C preferably
4, C
6Or C
8Alhpa olefin.
Four layers of composite membrane adopt five-layer co-squeezing downward-blowing water-cooling processing technique, also can adopt four layers of coextrusion casting method processing technique.
Barrier layer A can make composite membrane lustrous surface transparent as appearance with polyester.
Selecting for use with seven layers of composite membrane of binder resin selects for use anhydride modified polypropylene to improve heat resistance than the anhydride modified EVA that selected for use in the former method, binder resins such as anhydride modified EMA, anhydride modified LDPE.
The physical and mechanical properties of four layers of composite membrane, chemical property and biology performance all meet the requirement of infusion solutions packaging material, and price is low.
As mentioned above, four layers, five layers all are based on an identical design philosophy with seven layers of composite membrane, it provides corresponding performance respectively by each monolayer in the composite bed, and the result reaches good overall performance, and the multilayer complex films of gained all can be realized the splendid ratio of performance to price.But seven layers of composite membrane are owing to have many relatively compound numbers of plies, so adjustable extent is bigger, performance is better.
To further specify the present invention by specific embodiment below, but the embodiment that gives only is used for illustrative purposes and is not used in restriction the present invention.
Embodiment
Adopt the processing method of downward-blowing water-cooling coextrusion, make five layers of composite membrane: a/b/c/d/e, a wherein, the e layer is polypropylene and metallocene-plastomer blend, the c layer is the polyamide of 1.0-6.0g/10min for melt flow index, b, the acrylic resin that the d layer is anhydride modified, the thickness of each layer of gained compound film material is: a:75 μ, b:10 μ, c:20 μ, d:10 μ, e:75 μ.
The performance of these five layers of composite membranes sees the following form.
Five layers of composite membrane physical and mechanical properties of table 1
| Project | Method of testing | Standard index | Five layers of composite membrane | |
| Hot strength, MP | Vertically 〉= | GB 13022-91 | 30 | 31.6 |
| Laterally 〉= | GB 13022-91 | 24 | 24.7 | |
| Tension fracture elongation rate % | Vertically 〉= | GB 13022-91 | 400 | 488 |
| Laterally 〉= | GB 13022-91 | 400 | 408 | |
| Angle tear strength N/mm | Vertically 〉= | QB/T 1130-91 | 80 | 169 |
| Laterally 〉= | QB/T 1130-91 | 100 | 196 | |
| Flexibility | Tianjin Q/YY-3461-95 | * | * | |
| Light transmittance % | GB 2410-89 | 80 | 89.5 | |
| Mist degree % | GB 2410-89 | 20 | 16.4 | |
| Glossiness % | GB 8807-88 | 80 | 85.4 | |
| Vapor transfer rate g/m 2·d | GB 1037-88 | 5 | 3.88 | |
| Oxygen permeating amount ml/m 2·atm·24hr | GB/T 1038 | 50 | 34.9 | |
| Sterilizability | Disinfection with high pressure steam can reach 121 ℃ | |||
| Heat resistance ℃ | -10～121℃ | -10～125℃ | ||
| Percent thermal shrinkage % | Vertically 〉= | 3 | 1 | |
| Laterally 〉= | 3 | 1 | ||
Five layers of composite membrane of table 2 performance before and after autoclave sterilization compares
| Test event | Test result | |||
| Project | Unit | Method of testing | Five layers of composite membrane | |
| Before the sterilization | After the sterilization | |||
| Longitudinal tensile strength | MPa | GB/T 13022 | 31.6 | 37.8 |
| Transverse tensile strength | MPa | GB/T 13022 | 24.7 | 27.3 |
| The oxygen transit dose | cm 3/ m 2bar.d | GB/T 1038 | 34.9 | 32.6 |
| Steam penetrating capacity | g/m 2.24h | GB/T 1037 | 3.88 | 2.6 |
| Light transmittance | ％ | GB/T 2410 | 89.5 | 90.5 |
Annotate: sterilisation temp is that 121 ℃, pressure are 1kg/cm
2, disinfecting time 25 minutes.
As above shown in two tables, owing to adopted low-melting polypropylene and metallocene-plastomer blend as ectonexine with select the polyamide of flow index in 1.0g/10min～6.0g/min scope for use, thickness has improved the every physical and chemical performance and the biology performance of composite membrane significantly at 20-40 μ m.Can suitably change the polyamide layer thickness according to different purposes, thereby change the barrier property of composite membrane.
Though only having enumerated the specific embodiment and the combination property thereof of five layers of composite membrane here compares, but should be understood that, those skilled in the art can be according to description of the invention, easily implement preparation of four layers of composite membrane and seven layers of composite membrane and test, and within the scope of following claim, the general personnel in this area can carry out various changes and modifications to the present invention.
Claims (29)
1. seven layers of composite membrane, its composition is:
(a) intermediate layer (4) are barrier layers, and used resin is a polyamide;
(b) both sides of barrier layer are adhesive layer (3) and (5), and its composition is anhydride modified acrylic resin;
(c) outside of next-door neighbour's adhesive layer (3) is a layer (2), and the outside of next-door neighbour's adhesive layer (5) is a layer (6), and layer (2) is the identical symmetrical structure of prescription with layer (6), and composition is metallocene-plastomer and polyacrylic blend;
(d) outermost layer (1) is virgin pp or metallocene-plastomer and polyacrylic blend;
(e) innermost layer (7) is the blend of metallocene-plastomer and COPP.
2. the composite membrane of claim 1, wherein the polyamide described in (a) is to be selected from PA6, PA66, PA6/66, MXA-6 polyamide.
3. the composite membrane of claim 1, wherein the melt flow index of the polyamide described in (a) is in 1.0g/10min～6.0g/10min scope, and this layer thickness scope is 20 μ m～40 μ m.
4. the composite membrane of claim 1, wherein the melt flow index of the binder resin described in (b) is: 1.0g/10min～6.0g/10min, the thickness of layer (3) and (5) is 5 μ m～20 μ m.
5. the composite membrane of claim 1, wherein the weight percentage of metallocene-plastomer is in (c): 30%～70%, the thickness of layer (2) and layer (6) is 40 μ m～60 μ m.
6. the composite membrane of claim 5, wherein metallocene-plastomer is to be the active ethylene of list of Catalyst Production and the copolymer of alhpa olefin with the metallocene, wherein the content of alhpa olefin is: 20%～30%, density range is 0.89g/cm
3～0.92g/cm
3
7. the composite membrane of claim 6, wherein metallocene-plastomer is a metallocene linear low density polyethylene.
8. the composite membrane of claim 1, wherein the polypropylene described in (c) is the polypropylene of copolymerization.
9. the composite membrane of claim 1, wherein the metallocene-plastomer in (d) is to be the active ethylene of list of Catalyst Production and the copolymer of alhpa olefin with the metallocene, polypropylene is a COPP, wherein the weight percentage of metallocene-plastomer is: 0%～30%, and this layer thickness is 10 μ m～25 μ m.
10. the composite membrane of claim 1, wherein the metallocene-plastomer in (e) is to be the active ethylene of list of Catalyst Production and the copolymer of alhpa olefin with the metallocene, polypropylene is a COPP, wherein the weight percentage of metallocene-plastomer is 20%～50%, and this layer thickness is 30 μ m～40 μ m.
11. the composite membrane of claim 1, its from outside to inside put in order for: 1/2/3/4/5/6/7, the total thickness of this composite membrane is 170 μ m～200 μ m.
12. claim 6, one of 9 or 10 composite membrane, wherein said alhpa olefin is C
4, C
6Or C
8Alhpa olefin.
13. five layers of composite membrane, its composition is:
(1) intermediate layer (c) is barrier layer, and barrier resins is selected PA6, PA66, PA6/66, MXA-6 polyamide for use.
(2) both sides of barrier layer are adhesive layers (b) and (d), and binder resin is selected anhydride modified polypropylene for use.
(3) outermost layer (a) is the blend of metallocene-plastomer and COPP.
(4) innermost layer (e) is the blend of metallocene-plastomer and COPP.
14. the composite membrane of claim 13, wherein the melt flow index of (1) said polyamide is in the scope of 1.0g/10min～6.0g/10min, and the thickness range of this layer is 20 μ m～40 μ m.
15. the composite membrane of claim 13, wherein the melt flow index of the binder resin described in (2) is 1.0g/10min～6.0g/10min, and layer (b) and thickness (d) are 5 μ m～20 μ m.
16. the composite membrane of claim 13, wherein the weight percentage of metallocene-plastomer is 20%～40% in (3), and outermost layer thickness is 70 μ m～100 μ m.
17. the composite membrane of claim 13, wherein the weight percentage of metallocene-plastomer is 30%～60% in (4), and innermost layer thickness is 30 μ m～70 μ m.
18. the composite membrane of claim 13, wherein metallocene-plastomer is to be the active ethylene of list of Catalyst Production and the copolymer of alhpa olefin with the metallocene in (4).
19. the described composite membrane of claim 13, wherein the described COPP in outermost layer and the innermost layer is low-melting COPP.
20. the described composite membrane of claim 13, its outer to interior put in order for: a/b/c/d/e, its film gross thickness is: 170 μ m～200 μ m.
21. the composite membrane of claim 18, wherein said alhpa olefin is C
4, C
6Or C
8Alhpa olefin.
22. four layers of composite membrane, its composition is:
(1) outermost layer (A) is a barrier layer, and barrier resins is polyamide or polyester.
(2) that next-door neighbour (A) layer is adhesive layer (B), and binder resin is anhydride modified polypropylene.
(3) adjacent with adhesive layer (B) (C) layer is the blend of metallocene-plastomer and COPP.
(4) innermost layer (D) is adjacent with layer (C), and this layer is the blend of metallocene-plastomer and COPP.
23. the composite membrane of claim 22, wherein (1) said polyamide is to be selected from PA6, PA66, PA6/66, MXA-6 polyamide, and polyester is a copolyester, and the thickness of this layer is 20 μ m～40 μ m.
24. the composite membrane of claim 22, wherein the melt flow index of the binder resin described in (2) is: 1.0g/10min～6.0g/10min, the thickness of this layer are 5 μ m～20 μ m.
25. the composite membrane of claim 22, wherein the weight percentage of (C) layer metallocene-plastomer is in (3): 30%～70%, metallocene-plastomer is to be the active ethylene of list of Catalyst Production and the copolymer of alhpa olefin with the metallocene, wherein the content of alhpa olefin is: 20%～30%, and this layer thickness is 120 μ m～140 μ m.
26. the composite membrane of claim 22, wherein the metallocene-plastomer in (4) is to be the active ethylene of list of Catalyst Production and the copolymer of alhpa olefin with the metallocene, wherein the weight percentage of metallocene-plastomer is 20%～50%, and the D layer thickness is 20 μ m～40 μ m.
27. the composite membrane of claim 22, its order from outside to inside is: A/B/C/D, the total thickness of four layers of composite membrane are 170 μ m～200 μ m.
28. the composite membrane of claim 25 or 26, wherein said alhpa olefin is C
4, C
6Or C
8Alhpa olefin.
29. the described composite membrane of one of claim 1-28 is as the purposes of venous transfusion flexible packing material.
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|---|---|---|---|
| CN 01111112 CN1213853C (en) | 2001-02-28 | 2001-02-28 | Non-polyvinyl chloride compound film material for package of intravenous medicine |
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|---|---|---|---|
| CN 01111112 CN1213853C (en) | 2001-02-28 | 2001-02-28 | Non-polyvinyl chloride compound film material for package of intravenous medicine |
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| CN1213853C true CN1213853C (en) | 2005-08-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1970288B (en) * | 2006-09-20 | 2010-05-12 | 唐新国 | Seven-layer coextrusion membrane for transfusion and its production method |
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| DE112010003906B4 (en) * | 2009-10-02 | 2016-07-07 | Hosokawa Yoko Co., Ltd. | storage containers |
| CN101879800B (en) * | 2010-06-08 | 2013-03-13 | 湖北恒泰橡塑有限公司 | High-barrier medical film |
| CN102380991B (en) * | 2010-09-06 | 2014-09-10 | 苏州海顺包装材料有限公司 | Plastic packaging film and preparation method thereof |
| CN104497415B (en) * | 2014-11-28 | 2017-07-21 | 湖北恒泰橡塑有限公司 | Infusion bag thermoplastic elastomer (TPE) and preparation method thereof |
| CN111532011A (en) * | 2020-04-11 | 2020-08-14 | 上海紫泉标签有限公司 | Puncture-resistant high-strength film and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1970288B (en) * | 2006-09-20 | 2010-05-12 | 唐新国 | Seven-layer coextrusion membrane for transfusion and its production method |
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| CN1371803A (en) | 2002-10-02 |
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