CN1212121C - Product of ginsenoside for curing hepatitis - Google Patents
Product of ginsenoside for curing hepatitis Download PDFInfo
- Publication number
- CN1212121C CN1212121C CN 02160792 CN02160792A CN1212121C CN 1212121 C CN1212121 C CN 1212121C CN 02160792 CN02160792 CN 02160792 CN 02160792 A CN02160792 A CN 02160792A CN 1212121 C CN1212121 C CN 1212121C
- Authority
- CN
- China
- Prior art keywords
- ginsenoside monomer
- chinese medicine
- product
- ginsenoside
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 229930182494 ginsenoside Natural products 0.000 title claims abstract description 83
- 229940089161 ginsenoside Drugs 0.000 title claims abstract description 83
- 208000006454 hepatitis Diseases 0.000 title claims description 16
- 231100000283 hepatitis Toxicity 0.000 title claims description 10
- 239000000178 monomer Substances 0.000 claims abstract description 82
- 239000003814 drug Substances 0.000 claims abstract description 56
- 235000008434 ginseng Nutrition 0.000 claims abstract description 23
- 241000208340 Araliaceae Species 0.000 claims abstract description 22
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 22
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 22
- 239000000284 extract Substances 0.000 claims description 40
- 238000002360 preparation method Methods 0.000 claims description 13
- 239000009636 Huang Qi Substances 0.000 claims description 12
- 244000026873 Alternanthera philoxeroides Species 0.000 claims description 6
- 241000628997 Flos Species 0.000 claims description 6
- 229920001491 Lentinan Polymers 0.000 claims description 6
- 239000010231 banlangen Substances 0.000 claims description 6
- 150000004676 glycans Chemical class 0.000 claims description 6
- 229940115286 lentinan Drugs 0.000 claims description 6
- 229920001282 polysaccharide Polymers 0.000 claims description 6
- 239000005017 polysaccharide Substances 0.000 claims description 6
- 210000000582 semen Anatomy 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 18
- 239000001397 quillaja saponaria molina bark Substances 0.000 abstract description 4
- 229930182490 saponin Natural products 0.000 abstract description 4
- 150000007949 saponins Chemical class 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 208000019423 liver disease Diseases 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 26
- 239000000047 product Substances 0.000 description 25
- 208000002672 hepatitis B Diseases 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000010791 quenching Methods 0.000 description 8
- 230000000171 quenching effect Effects 0.000 description 8
- 238000010992 reflux Methods 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 206010008909 Chronic Hepatitis Diseases 0.000 description 6
- 206010020772 Hypertension Diseases 0.000 description 6
- 208000019425 cirrhosis of liver Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 5
- 229940046011 buccal tablet Drugs 0.000 description 4
- 239000006189 buccal tablet Substances 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229940023488 pill Drugs 0.000 description 4
- 239000006187 pill Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 230000001256 tonic effect Effects 0.000 description 2
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a product composed of ginsenoside monomers for treating hepatic disease. The present invention is characterized in that the product comprises the following raw materials by the weight ratio: 1 portion of ginsenoside monomer Rg5 and 0.1 to 10 portions of ginsenoside monomer RH1. The product has no side effect. Compared with the existing medicines for treating hepatic disease, the product has the advantages of good effect, short treatment course and low expense. The product also has the body building effect of ginseng. The present invention enlarges the use range of ginseng and fully utilizes the monomeric saponin peculiar to ginseng, and thus, thus, ginseng is applied more extensively, more scientifically and more reasonably.
Description
Technical field:
The present invention relates to a kind of product that utilizes Radix Ginseng extract to make, particularly a kind of product of ginsenoside monomer compatibility treatment hepatitis is mainly used in diseases such as treatment hepatitis B, chronic hepatitis, liver cirrhosis, hypertension.
Background technology:
As everyone knows, Radix Ginseng is famous and precious tonic, and its Main Ingredients and Appearance is a saponin, has been found that contained ginsenoside reaches 37 kinds in the Radix Ginseng.At present to ginsenoside's utilization science not also, traditional method is that Radix Ginseng is directly edible or boil and drink as the tonic of building body, make the eater feel scorching, the deficiency of YIN, hyperactivity of fire, can not fully absorb the nutrition in it, be difficult to embody the medical value of Radix Ginseng.
Treatment for hepatopathy mainly is the compatibility that utilizes general Chinese crude drug at present.This quasi drugs uncertain therapeutic efficacy is cut, and the treatment phase is long, and the expense height is taken for a long time and can be had side effects, and impairs the health of health.
Summary of the invention:
The purpose of this invention is to provide a kind of product of ginsenoside monomer compatibility treatment hepatitis disease without any side effects, eutherapeutic, be mainly used in diseases such as hepatitis B, chronic hepatitis, liver cirrhosis, hypertension., having effectively utilized the contained peculiar saponin monomer composition of Radix Ginseng, the utilization that makes Radix Ginseng is science, economy, rationally more.
Technical solution of the present invention is: a kind of product of ginsenoside monomer compatibility treatment hepatitis, it is characterized in that: it comprises ginsenoside monomer Rg
5, ginsenoside monomer RH
1, its weight proportion is as follows:
Ginsenoside monomer Rg
5: ginsenoside monomer RH
1Be 1: (0.1-10),
This product also comprises ginsenoside monomer Rg
3, its weight proportion is as follows:
Ginsenoside monomer Rg
5: ginsenoside monomer Rg
3Be 1: (0.1-10).
This product also comprises ginsenoside monomer RH
6, its weight proportion is as follows:
Ginsenoside monomer Rg
5: ginsenoside monomer RH
6Be 1: (0.1-10).
This product also comprises Chinese medicine extract, and described Chinese medicine is: Herba Apocyni veneti, Spica Prunellae, Semen Cassiae, Flos Chrysanthemi, hook are risen, Radix Puerariae, the Radix Astragali, Radix Rhodiolae, river Os Draconis, and each Chinese medicine extract is equal portions preparation, ginsenoside monomer Rg
5As follows with the weight proportion of Chinese medicine extract:
Ginsenoside monomer Rg
5: Chinese medicine extract is 1: (0.1-10).
This product also comprises Chinese medicine extract, described Chinese medicine is: ginseng polysaccharide, lentinan, the Radix Astragali, Spica Prunellae, Radix Et Caulis Acanthopanacis Senticosi, alligator weed, Radix Rhodiolae, Coriolous Dersicolor (Fr.) Quel, Radix Bupleuri, Herba Artemisiae Scopariae, Radix Isatidis, Fructus Schisandrae Chinensis, each Chinese medicine extract is equal portions preparation, ginsenoside monomer Rg
5As follows with the weight proportion of Chinese medicine extract:
Ginsenoside monomer Rg
5: Chinese medicine extract is 1: (0.1-10).
The present invention has following advantage: without any side effects, compare with the medicine of the above-mentioned disease of existing treatment effective, the treatment phase is short, expense is low.The effect that has the building body of Radix Ginseng equally.The present invention has enlarged the scope of application of Radix Ginseng, has made full use of the distinctive saponin monomer composition in the Radix Ginseng, makes the application of Radix Ginseng more extensive, science, more reasonable more.
The specific embodiment:
Below in conjunction with the specific embodiment the present invention is further described:
Employed ginsenoside monomer Rg among the present invention
5, ginsenoside monomer RH
1, ginsenoside monomer Rg
3, ginsenoside monomer RH
6All utilize bionic method extraction separation from Radix Ginseng, because this method is simple to operate, output capacity is high, makes product cost of the present invention low.Described Radix Ginseng also can be Radix Panacis Quinquefolii or Korean Ginseng or Radix Notoginseng.
The specific embodiment 1:
A, get purity and be 10% ginsenoside monomer Rg
5, ginsenoside monomer RH
1, carry out compatibility and mix, its weight ratio is pressed ginsenoside monomer Rg
5: ginsenoside monomer RH
1Be to prepare at 1: 0.1.
Get purity and be 10% ginsenoside monomer Rg
5500 grams, ginsenoside monomer RH
150 grams, above-mentioned ginsenoside monomer mixture is a pulverulence, adopts the gradient method mix homogeneously to get final product.In order to make this product have better therapeutic effect, can be added with purity and be 10% ginsenoside monomer Rg
350 grams, 10% ginsenoside monomer RH
650 grams.
Be added with in product that Herba Apocyni veneti, Spica Prunellae, Semen Cassiae, Flos Chrysanthemi, hook rise, Radix Puerariae, the Radix Astragali, Radix Rhodiolae, river Os Draconis Chinese medicine extract effect be better, simultaneously the hyperpietic had curative effect preferably.Described Chinese medicine extract is equal portions preparation, adopts traditional hot reflux extracting mode or the supercritical mode of getting of quenching that Chinese medicine is extracted.Get the dry Powdered Chinese medicine extract in back of 5 grams and the said goods mix homogeneously.
It is better to sick effects such as treatment hepatitis B, chronic hepatitis, liver cirrhosis, hypertension to be added with ginseng polysaccharide, lentinan, the Radix Astragali, Spica Prunellae, Radix Et Caulis Acanthopanacis Senticosi, alligator weed, Radix Rhodiolae, Coriolous Dersicolor (Fr.) Quel, Radix Bupleuri, Herba Artemisiae Scopariae, Radix Isatidis, Fructus Schisandrae Chinensis Chinese medicine extract in product.Described Chinese medicine extract is equal portions preparation, adopts traditional hot reflux extracting mode or the supercritical mode of getting of quenching that Chinese medicine is extracted.Get the dry Powdered Chinese medicine extract in back of 5 grams and the said goods mix homogeneously.
Adopt common pharmaceutical technology that said mixture is made oral liquid or buccal tablet or electuary or tablet or drop pill or capsule or close ball.
B, get purity and be 80% ginsenoside monomer Rg
5, ginsenoside monomer RH
1, carry out compatibility and mix, its weight ratio is pressed ginsenoside monomer Rg
5: ginsenoside monomer RH
1Be to prepare at 1: 0.1.
Get purity and be 80% ginsenoside monomer Rg
562.5 gram, ginsenoside monomer RH
16.25 gram, above-mentioned ginsenoside monomer mixture is a pulverulence, adopts the gradient method mix homogeneously to get final product.In order to make this product have better therapeutic effect, can be added with purity and be 80% ginsenoside monomer Rg
36.25 gram, 80% ginsenoside monomer RH
66.25 gram.
Be added with in product that Herba Apocyni veneti, Spica Prunellae, Semen Cassiae, Flos Chrysanthemi, hook rise, Radix Puerariae, the Radix Astragali, Radix Rhodiolae, river Os Draconis Chinese medicine extract effect be better, simultaneously the hyperpietic had curative effect preferably.Described Chinese medicine extract is equal portions preparation, adopts traditional hot reflux extracting mode or the supercritical mode of getting of quenching that Chinese medicine is extracted.Get the dry Powdered Chinese medicine extract in back of 5 grams and the said goods mix homogeneously.
It is better to sick effects such as treatment hepatitis B, chronic hepatitis, liver cirrhosis, hypertension to be added with ginseng polysaccharide, lentinan, the Radix Astragali, Spica Prunellae, Radix Et Caulis Acanthopanacis Senticosi, alligator weed, Radix Rhodiolae, Coriolous Dersicolor (Fr.) Quel, Radix Bupleuri, Herba Artemisiae Scopariae, Radix Isatidis, Fructus Schisandrae Chinensis Chinese medicine extract in product.Described Chinese medicine extract is equal portions preparation, adopts traditional hot reflux extracting mode or the supercritical mode of getting of quenching that Chinese medicine is extracted.Get the dry Powdered Chinese medicine extract in back of 5 grams and the said goods mix homogeneously.
Adopt common pharmaceutical technology that said mixture is made oral liquid or buccal tablet or electuary or tablet or drop pill or capsule or close ball.
In process for preparation, as each monomeric purity difference, available its weight changes adjustment, as long as weight proportion is in institute's restricted portion.
The specific embodiment 2:
Get purity and be 10% ginsenoside monomer Rg
5, ginsenoside monomer RH
1Carry out compatibility and mix, its weight ratio is pressed ginsenoside monomer Rg
5: ginsenoside monomer RH
1Be to prepare at 1: 10.
Get purity and be 10% ginsenoside monomer Rg
3500 grams, ginsenoside monomer RH
15000 grams, above-mentioned ginsenoside monomer mixture is a pulverulence, adopts the gradient method mix homogeneously to get final product.In order to make this product have better therapeutic effect, can be added with purity and be 10% ginsenoside monomer Rg
35000 grams, 10% ginsenoside monomer RH
65000 grams.
Be added with in product that Herba Apocyni veneti, Spica Prunellae, Semen Cassiae, Flos Chrysanthemi, hook rise, Radix Puerariae, the Radix Astragali, Radix Rhodiolae, river Os Draconis Chinese medicine extract effect be better, simultaneously the hyperpietic had curative effect preferably.Described Chinese medicine extract is equal portions preparation, adopts traditional hot reflux extracting mode or the supercritical mode of getting of quenching that Chinese medicine is extracted.Get the dry Powdered Chinese medicine extract in back of 500 grams and the said goods mix homogeneously.
It is better to sick effects such as treatment hepatitis B, chronic hepatitis, liver cirrhosis, hypertension to be added with ginseng polysaccharide, lentinan, the Radix Astragali, Spica Prunellae, Radix Et Caulis Acanthopanacis Senticosi, alligator weed, Radix Rhodiolae, Coriolous Dersicolor (Fr.) Quel, Radix Bupleuri, Herba Artemisiae Scopariae, Radix Isatidis, Fructus Schisandrae Chinensis Chinese medicine extract in product.Described Chinese medicine extract is equal portions preparation, adopts traditional hot reflux extracting mode or the supercritical mode of getting of quenching that Chinese medicine is extracted.Get the dry Powdered Chinese medicine extract in back of 500 grams and the said goods mix homogeneously.
Adopt common pharmaceutical technology that said mixture is made oral liquid or buccal tablet or electuary or tablet or drop pill or the close ball of capsule.
The specific embodiment 3:
Get purity and be 10% ginsenoside monomer Rg
5, ginsenoside monomer RH
1, carry out compatibility and mix, its weight ratio is pressed ginsenoside monomer Rg
5: ginsenoside monomer RH
1Be to prepare at 1: 5.
Get purity and be 10% ginsenoside monomer Rg
3500 grams, ginsenoside monomer RH
12500 grams, above-mentioned ginsenoside monomer mixture is a pulverulence, adopts the gradient method mix homogeneously to get final product.In order to make this product have better therapeutic effect, can be added with purity and be 10% ginsenoside monomer Rg
32000 grams, 10% ginsenoside monomer RH
64000 grams.
Be added with in product that Herba Apocyni veneti, Spica Prunellae, Semen Cassiae, Flos Chrysanthemi, hook rise, Radix Puerariae, the Radix Astragali, Radix Rhodiolae, river Os Draconis Chinese medicine extract effect be better, simultaneously the hyperpietic had curative effect preferably.Described Chinese medicine extract is equal portions preparation, adopts traditional hot reflux extracting mode or the supercritical mode of getting of quenching that Chinese medicine is extracted.Get the dry Powdered Chinese medicine extract in back of 300 grams and the said goods mix homogeneously.
It is better to sick effects such as treatment hepatitis B, chronic hepatitis, liver cirrhosis, hypertension to be added with ginseng polysaccharide, lentinan, the Radix Astragali, Spica Prunellae, Radix Et Caulis Acanthopanacis Senticosi, alligator weed, Radix Rhodiolae, Coriolous Dersicolor (Fr.) Quel, Radix Bupleuri, Herba Artemisiae Scopariae, Radix Isatidis, Fructus Schisandrae Chinensis Chinese medicine extract in product.Described Chinese medicine extract is equal portions preparation, adopts traditional hot reflux extracting mode or the supercritical mode of getting of quenching that Chinese medicine is extracted.Get the dry Powdered Chinese medicine extract in back of 200 grams and the said goods mix homogeneously.
Adopt common pharmaceutical technology that said mixture is made oral liquid or buccal tablet or electuary or tablet or drop pill or capsule or close ball.
Example 1: in victory, the man, the life on the 15th of nineteen fifty-seven JIUYUE was suffered from hepatitis B sick 3 years, took this product, and through 6 months take, disease disappeared at present, and health is got well.
Example 2: Li Weiyu, the woman, the life on the 5th of nineteen sixty-eight December was suffered from hepatitis B sick 3 years, took this product, and through 5 months take, disease disappeared at present, and health is got well, and test rating is all normal.
Example 3: Li Danshi, the man, nineteen fifty-two life on July 11 was suffered from hepatitis B sick 5 years, took this product, and through 7 months take, disease disappeared at present, and life is normal, and the health check-up index is normal.
Claims (5)
1, a kind of product of ginsenoside monomer compatibility treatment hepatitis, it is characterized in that: it comprises ginsenoside monomer Rg
5, ginsenoside monomer RH
1, its weight proportion is as follows:
Ginsenoside monomer Rg
5: ginsenoside monomer RH
1Be 1: (0.1-10).
2, the product of ginsenoside monomer compatibility treatment hepatitis according to claim 1, it is characterized in that: it also comprises ginsenoside monomer Rg
3, its weight proportion is as follows:
Ginsenoside monomer Rg
5: ginsenoside monomer Rg
3Be 1: (0.1-10).
3, the product of ginsenoside monomer compatibility treatment hepatitis according to claim 1 and 2, it is characterized in that: it also comprises ginsenoside monomer RH
6, its weight proportion is as follows:
Ginsenoside monomer Rg
5: ginsenoside monomer RH
6Be 1: (0.1-10).
4, the product of ginsenoside monomer compatibility treatment hepatitis according to claim 3, it is characterized in that: it also comprises Chinese medicine extract, described Chinese medicine is: Herba Apocyni veneti, Spica Prunellae, Semen Cassiae, Flos Chrysanthemi, hook are risen, Radix Puerariae, the Radix Astragali, Radix Rhodiolae, river Os Draconis, each Chinese medicine extract is equal portions preparation, ginsenoside monomer Rg
5As follows with the weight proportion of Chinese medicine extract:
Ginsenoside monomer Rg
5: Chinese medicine extract is 1: (0.1-10).
5, the product of ginsenoside monomer compatibility treatment hepatitis according to claim 3, it is characterized in that: it also comprises Chinese medicine extract, described Chinese medicine is: ginseng polysaccharide, lentinan, the Radix Astragali, Spica Prunellae, Radix Et Caulis Acanthopanacis Senticosi, alligator weed, Radix Rhodiolae, Coriolous Dersicolor (Fr.) Quel, Radix Bupleuri, Herba Artemisiae Scopariae, Radix Isatidis, Fructus Schisandrae Chinensis, each Chinese medicine extract is equal portions preparation, ginsenoside monomer Rg
5As follows with the weight proportion of Chinese medicine extract:
Ginsenoside monomer Rg
5: Chinese medicine extract is 1: (0.1-10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02160792 CN1212121C (en) | 2002-12-28 | 2002-12-28 | Product of ginsenoside for curing hepatitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02160792 CN1212121C (en) | 2002-12-28 | 2002-12-28 | Product of ginsenoside for curing hepatitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1425383A CN1425383A (en) | 2003-06-25 |
| CN1212121C true CN1212121C (en) | 2005-07-27 |
Family
ID=4753482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02160792 Expired - Lifetime CN1212121C (en) | 2002-12-28 | 2002-12-28 | Product of ginsenoside for curing hepatitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1212121C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104643058A (en) * | 2013-11-21 | 2015-05-27 | 富力 | Application of 20(R)-ginsenoside Rg3 in preparation of medicines for improving or/and treating liver cirrhosis diseases |
| CN104644662A (en) * | 2013-11-22 | 2015-05-27 | 富力 | Application of 20(R)-ginsenoside Rg3 in preparation of medicine for relieving and/or treating alcoholic liver disease and medicine |
| CN104194980A (en) * | 2013-12-07 | 2014-12-10 | 李光明 | Skincare healthcare perfumed soap and preparing method |
-
2002
- 2002-12-28 CN CN 02160792 patent/CN1212121C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1425383A (en) | 2003-06-25 |
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