CN1207004C - 通用型冻干血浆及其制备方法 - Google Patents
通用型冻干血浆及其制备方法 Download PDFInfo
- Publication number
- CN1207004C CN1207004C CNB011066377A CN01106637A CN1207004C CN 1207004 C CN1207004 C CN 1207004C CN B011066377 A CNB011066377 A CN B011066377A CN 01106637 A CN01106637 A CN 01106637A CN 1207004 C CN1207004 C CN 1207004C
- Authority
- CN
- China
- Prior art keywords
- blood plasma
- type
- blood
- plasma
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 32
- 239000008280 blood Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 210000002381 plasma Anatomy 0.000 claims abstract description 106
- 241000700605 Viruses Species 0.000 claims abstract description 9
- 239000003223 protective agent Substances 0.000 claims abstract description 9
- 230000002779 inactivation Effects 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 10
- 230000009849 deactivation Effects 0.000 claims description 5
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 4
- 101710186708 Agglutinin Proteins 0.000 claims description 3
- 101710146024 Horcolin Proteins 0.000 claims description 3
- 101710189395 Lectin Proteins 0.000 claims description 3
- 101710179758 Mannose-specific lectin Proteins 0.000 claims description 3
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 claims description 3
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 claims description 3
- 239000000910 agglutinin Substances 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- 108010049003 Fibrinogen Proteins 0.000 claims description 2
- 102000008946 Fibrinogen Human genes 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 108010024636 Glutathione Proteins 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 229940012952 fibrinogen Drugs 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 229960003180 glutathione Drugs 0.000 claims description 2
- 230000000415 inactivating effect Effects 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 1
- 239000003114 blood coagulation factor Substances 0.000 abstract 1
- 229940019700 blood coagulation factors Drugs 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000004520 agglutination Effects 0.000 description 5
- 108090000190 Thrombin Proteins 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 229960004072 thrombin Drugs 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 235000007926 Craterellus fallax Nutrition 0.000 description 1
- 240000007175 Datura inoxia Species 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
组别 | 各型血浆混合比例(%) | 凝集效价滴度 | 备注 | ||||
A型 | B型 | O型 | AB型 | 抗A | 抗B | ||
1# | 50 | 20 | 20 | 10 | 1∶2 | 1∶8 | |
2# | 50 | 30 | 10 | 10 | 1∶2 | 1∶4 | |
3# | 60 | 30 | 5 | 5 | 1∶2 | 1∶4 | |
4# | 50 | 35 | 5 | 10 | 1∶2 | 1∶4 |
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011066377A CN1207004C (zh) | 2001-04-18 | 2001-04-18 | 通用型冻干血浆及其制备方法 |
PCT/CN2002/000264 WO2002083157A1 (fr) | 2001-04-18 | 2002-04-17 | Plasma sanguin humain exempt de groupe sanguin et son procede de preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011066377A CN1207004C (zh) | 2001-04-18 | 2001-04-18 | 通用型冻干血浆及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1321468A CN1321468A (zh) | 2001-11-14 |
CN1207004C true CN1207004C (zh) | 2005-06-22 |
Family
ID=4655626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB011066377A Expired - Lifetime CN1207004C (zh) | 2001-04-18 | 2001-04-18 | 通用型冻干血浆及其制备方法 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN1207004C (zh) |
WO (1) | WO2002083157A1 (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007514716A (ja) * | 2003-12-19 | 2007-06-07 | オクタファルマ アクチェン ゲゼルシャフト | 非白色人種血漿の部分より製造される、万人に適用可能なウイルス不活化血漿 |
CN100431550C (zh) * | 2005-01-12 | 2008-11-12 | 马建川 | 通用型新鲜冰冻血浆 |
FR2963737B1 (fr) * | 2010-08-16 | 2013-04-05 | Etat Francais Ministere De La Defense Service De Sante Des Armees | Procede de lyophilisation de plasma sanguin |
US9561184B2 (en) | 2014-09-19 | 2017-02-07 | Velico Medical, Inc. | Methods and systems for multi-stage drying of plasma |
CN105832768A (zh) * | 2015-08-11 | 2016-08-10 | 杜祖英 | 具有多种功能的人血浆及其制备方法 |
WO2019074886A1 (en) | 2017-10-09 | 2019-04-18 | Terumo Bct Biotechnologies, Llc | LYOPHILIZATION CONTAINER AND METHOD OF USE |
EP3937878A2 (en) | 2019-03-14 | 2022-01-19 | Terumo BCT Biotechnologies, LLC | Lyophilization loading tray assembly and system |
CN114617903B (zh) * | 2022-03-15 | 2024-05-24 | 中国人民解放军总医院第一医学中心 | 一种用于血浆冻干的组合物及其应用 |
US11975274B2 (en) | 2022-09-15 | 2024-05-07 | Velico Medical, Inc. | Blood plasma product |
US11998861B2 (en) | 2022-09-15 | 2024-06-04 | Velico Medical, Inc. | Usability of a disposable for a spray drying plasma system |
US11841189B1 (en) | 2022-09-15 | 2023-12-12 | Velico Medical, Inc. | Disposable for a spray drying system |
US12083447B2 (en) | 2022-09-15 | 2024-09-10 | Velico Medical, Inc. | Alignment of a disposable for a spray drying plasma system |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4664913A (en) * | 1982-05-24 | 1987-05-12 | Xoma Corporation | Method for treating plasma for transfusion |
CN1042474A (zh) * | 1988-11-10 | 1990-05-30 | 济南军区药物研究中心 | 果胶代血浆及制备方法 |
EP0896824A1 (en) * | 1997-08-05 | 1999-02-17 | Octapharma Ag | A universally applicable blood plasma |
-
2001
- 2001-04-18 CN CNB011066377A patent/CN1207004C/zh not_active Expired - Lifetime
-
2002
- 2002-04-17 WO PCT/CN2002/000264 patent/WO2002083157A1/zh not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1321468A (zh) | 2001-11-14 |
WO2002083157A1 (fr) | 2002-10-24 |
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Legal Events
Date | Code | Title | Description |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PD01 | Discharge of preservation of patent |
Date of registration: 20061220 Pledge (preservation): Preservation |
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C57 | Notification of unclear or unknown address | ||
DD01 | Delivery of document by public notice |
Addressee: Ma Jianchuan Document name: Notice of termination of proceedings |
|
C56 | Change in the name or address of the patentee |
Owner name: SHANDONG MICHELLE BIOLOGICAL ENGINEERING CO., LTD. Free format text: FORMER NAME OR ADDRESS: MA JIANCHUAN |
|
CP03 | Change of name, title or address |
Address after: Room 3, building 52, No. 206, East Jiaotong University Road, Beijing, Haidian District Patentee after: Shandong Michel Biological Engineering Co., Ltd. Address before: Shuming road Chengdu City, Sichuan Province Road No. 3 happy Shu Feng Jing A-2-11B Patentee before: Ma Jianchuan |
|
ASS | Succession or assignment of patent right |
Owner name: WUHAN HUALONG TAIKANG BIOLOGICAL PRODUCTS CO., LT Free format text: FORMER OWNER: SHANDONG MICHELLE BIOLOGICAL ENGINEERING CO., LTD. Effective date: 20081010 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20081010 Address after: 12, 3, 6, 1 floor, Hou Hu ecological garden, Jiang'an District, Wuhan, Hubei Patentee after: Wuhan Hualong Taikang biologicals Co., Ltd. Address before: Room 3, building 52, No. 206, East Jiaotong University Road, Beijing, Haidian District Patentee before: Shandong Michel Biological Engineering Co., Ltd. |
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C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050622 Termination date: 20120418 |
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RR01 | Reinstatement of patent right |
Former decision: termination of patent right due to unpaid annual fee Former decision publication date: 20131204 |
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CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20050622 |
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DD01 | Delivery of document by public notice | ||
DD01 | Delivery of document by public notice |
Addressee: Patent of Wuhan Hualong Taikang Biological Products Co.,Ltd. The person in charge Document name: Notice of termination of patent right |