CN120569367A - 多巴胺d3/d2受体调节化合物 - Google Patents

多巴胺d3/d2受体调节化合物

Info

Publication number
CN120569367A
CN120569367A CN202480007498.6A CN202480007498A CN120569367A CN 120569367 A CN120569367 A CN 120569367A CN 202480007498 A CN202480007498 A CN 202480007498A CN 120569367 A CN120569367 A CN 120569367A
Authority
CN
China
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
formula
present disclosure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202480007498.6A
Other languages
English (en)
Chinese (zh)
Inventor
I·博尔扎
J·埃莱斯
B·门辛格
S·博德纳内迪克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of CN120569367A publication Critical patent/CN120569367A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202480007498.6A 2023-01-11 2024-01-10 多巴胺d3/d2受体调节化合物 Pending CN120569367A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202363479530P 2023-01-11 2023-01-11
US63/479530 2023-01-11
PCT/IB2024/000026 WO2024150068A2 (en) 2023-01-11 2024-01-10 Dopamine d3/d2 receptor modulating compounds

Publications (1)

Publication Number Publication Date
CN120569367A true CN120569367A (zh) 2025-08-29

Family

ID=89573273

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202480007498.6A Pending CN120569367A (zh) 2023-01-11 2024-01-10 多巴胺d3/d2受体调节化合物

Country Status (16)

Country Link
US (2) US12168007B1 (https=)
EP (1) EP4400495A1 (https=)
JP (2) JP7686096B2 (https=)
KR (2) KR102921799B1 (https=)
CN (1) CN120569367A (https=)
AR (1) AR131577A1 (https=)
AU (1) AU2024208533A1 (https=)
CL (1) CL2025002035A1 (https=)
CO (1) CO2025010725A2 (https=)
GE (1) GEAP202516807A (https=)
IL (1) IL321654A (https=)
JO (1) JOP20250164A1 (https=)
MX (1) MX2025008101A (https=)
PE (1) PE20260287A1 (https=)
TW (1) TW202432139A (https=)
WO (1) WO2024150068A2 (https=)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
EP1870405A1 (en) 2006-06-22 2007-12-26 Bioprojet Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
CA2937222C (en) 2009-06-25 2019-06-04 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
WO2020156312A1 (zh) 2019-01-30 2020-08-06 江苏豪森药业集团有限公司 一种多环类衍生物调节剂、其制备方法和应用
MX2022004473A (es) 2019-10-29 2022-05-06 Shanghai Hansoh Biomedical Co Ltd Modificador de un derivado de anillo de cuatro miembros, metodo de preparacion y aplicacion del mismo.
US12459931B2 (en) * 2019-11-05 2025-11-04 Shanghai Hansoh Biomedical Co., Ltd. Benzothiophene derivative regulator, preparation method therefor and use thereof

Also Published As

Publication number Publication date
PE20260287A1 (es) 2026-02-10
TW202432139A (zh) 2024-08-16
JP7686096B2 (ja) 2025-05-30
JP2024098972A (ja) 2024-07-24
EP4400495A1 (en) 2024-07-17
JP2025122072A (ja) 2025-08-20
IL321654A (en) 2025-08-01
KR20240112213A (ko) 2024-07-18
AU2024208533A1 (en) 2025-07-10
JOP20250164A1 (ar) 2025-07-10
KR102921799B1 (ko) 2026-02-04
WO2024150068A2 (en) 2024-07-18
KR20260019592A (ko) 2026-02-10
AR131577A1 (es) 2025-04-09
WO2024150068A3 (en) 2024-08-22
MX2025008101A (es) 2025-08-01
GEAP202516807A (en) 2025-08-25
CL2025002035A1 (es) 2025-10-03
US20250049786A1 (en) 2025-02-13
CO2025010725A2 (es) 2025-08-29
US12168007B1 (en) 2024-12-17

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