CN120484131A - 包含磷脂酰肌醇蛋白聚糖2结合结构域的嵌合抗原受体 - Google Patents

包含磷脂酰肌醇蛋白聚糖2结合结构域的嵌合抗原受体

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Publication number
CN120484131A
CN120484131A CN202510522686.9A CN202510522686A CN120484131A CN 120484131 A CN120484131 A CN 120484131A CN 202510522686 A CN202510522686 A CN 202510522686A CN 120484131 A CN120484131 A CN 120484131A
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CN
China
Prior art keywords
seq
amino acid
domain
acid sequence
chain variable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510522686.9A
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English (en)
Chinese (zh)
Inventor
克里斯托弗·博塞
约翰·马里斯
大卫·巴雷特
杰西卡·福斯特
迪米特尔·迪米特罗夫
克里斯特尔·麦克尔
罗比·迈茨纳
朱忠玉
赛宾·海策内德
东乔·V·叶列夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital of Philadelphia CHOP
Leland Stanford Junior University
US Department of Health and Human Services
Original Assignee
Childrens Hospital of Philadelphia CHOP
Leland Stanford Junior University
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital of Philadelphia CHOP, Leland Stanford Junior University, US Department of Health and Human Services filed Critical Childrens Hospital of Philadelphia CHOP
Publication of CN120484131A publication Critical patent/CN120484131A/zh
Pending legal-status Critical Current

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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K40/42—Cancer antigens
    • A61K40/4261—Proteoglycans, e.g. glypican, brevican or CSPG4
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CN202510522686.9A 2019-07-19 2020-07-17 包含磷脂酰肌醇蛋白聚糖2结合结构域的嵌合抗原受体 Pending CN120484131A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962876483P 2019-07-19 2019-07-19
US62/876,483 2019-07-19
CN202080052372.2A CN114555807B (zh) 2019-07-19 2020-07-17 包含磷脂酰肌醇蛋白聚糖2结合结构域的嵌合抗原受体
PCT/US2020/042469 WO2021016062A1 (en) 2019-07-19 2020-07-17 Chimeric antigen receptors containing glypican 2 binding domains

Related Parent Applications (1)

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CN202080052372.2A Division CN114555807B (zh) 2019-07-19 2020-07-17 包含磷脂酰肌醇蛋白聚糖2结合结构域的嵌合抗原受体

Publications (1)

Publication Number Publication Date
CN120484131A true CN120484131A (zh) 2025-08-15

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN202510522686.9A Pending CN120484131A (zh) 2019-07-19 2020-07-17 包含磷脂酰肌醇蛋白聚糖2结合结构域的嵌合抗原受体
CN202080052372.2A Active CN114555807B (zh) 2019-07-19 2020-07-17 包含磷脂酰肌醇蛋白聚糖2结合结构域的嵌合抗原受体
CN202510075685.4A Pending CN119925596A (zh) 2019-07-19 2020-07-17 包含磷脂酰肌醇蛋白聚糖2结合结构域的嵌合抗原受体

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CN202080052372.2A Active CN114555807B (zh) 2019-07-19 2020-07-17 包含磷脂酰肌醇蛋白聚糖2结合结构域的嵌合抗原受体
CN202510075685.4A Pending CN119925596A (zh) 2019-07-19 2020-07-17 包含磷脂酰肌醇蛋白聚糖2结合结构域的嵌合抗原受体

Country Status (6)

Country Link
US (1) US20220257653A1 (https=)
EP (1) EP3999546A1 (https=)
JP (2) JP2022541538A (https=)
CN (3) CN120484131A (https=)
AU (1) AU2020317009A1 (https=)
WO (1) WO2021016062A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3139319A1 (en) * 2019-05-07 2020-11-12 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of polypeptides and chimeric antigen receptors via hinge domains
WO2023107898A1 (en) * 2021-12-06 2023-06-15 The Children's Hospital Of Philadelphia Dual targeting of pediatric malignancies through car t-cells secreting bispecific innate immune cell engagers (bices)
WO2025235598A1 (en) * 2024-05-09 2025-11-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting glypican-2 and/or cd276 and their use for treating solid tumors

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