CN120114457A - 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂 - Google Patents

用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂 Download PDF

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Publication number
CN120114457A
CN120114457A CN202510299373.1A CN202510299373A CN120114457A CN 120114457 A CN120114457 A CN 120114457A CN 202510299373 A CN202510299373 A CN 202510299373A CN 120114457 A CN120114457 A CN 120114457A
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China
Prior art keywords
certain embodiments
alkyl
compound
hydrogen
pmm2
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Pending
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CN202510299373.1A
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English (en)
Chinese (zh)
Inventor
R·佩尔费蒂
S·申德曼
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Applied Therapy Co
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Applied Therapy Co
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Publication of CN120114457A publication Critical patent/CN120114457A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CN202510299373.1A 2019-10-08 2020-10-07 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂 Pending CN120114457A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962912441P 2019-10-08 2019-10-08
US62/912,441 2019-10-08
CN202080070704.XA CN114667139B (zh) 2019-10-08 2020-10-07 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂
PCT/US2020/054607 WO2021071965A1 (en) 2019-10-08 2020-10-07 Aldose reductase inhibitors for treatment of phosphomannomutase 2 deficiency

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202080070704.XA Division CN114667139B (zh) 2019-10-08 2020-10-07 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂

Publications (1)

Publication Number Publication Date
CN120114457A true CN120114457A (zh) 2025-06-10

Family

ID=75437528

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202510299373.1A Pending CN120114457A (zh) 2019-10-08 2020-10-07 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂
CN202510299188.2A Pending CN120093757A (zh) 2019-10-08 2020-10-07 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂
CN202080070704.XA Active CN114667139B (zh) 2019-10-08 2020-10-07 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202510299188.2A Pending CN120093757A (zh) 2019-10-08 2020-10-07 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂
CN202080070704.XA Active CN114667139B (zh) 2019-10-08 2020-10-07 用于治疗磷酸甘露变位酶2缺乏的醛糖还原酶抑制剂

Country Status (10)

Country Link
US (1) US20220226323A1 (https=)
EP (1) EP4041219A4 (https=)
JP (2) JP7778686B2 (https=)
CN (3) CN120114457A (https=)
AU (1) AU2020363699A1 (https=)
BR (1) BR112022005895A2 (https=)
CA (1) CA3153108A1 (https=)
IL (1) IL291946A (https=)
MX (1) MX2022004270A (https=)
WO (1) WO2021071965A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL272246B2 (en) 2017-07-28 2026-01-01 Applied Therapeutics Inc History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
CA3132136A1 (en) 2019-04-01 2020-10-08 Andrew Wasmuth Inhibitors of aldose reductase
JP2022531466A (ja) 2019-05-07 2022-07-06 ユニバーシティ オブ マイアミ 遺伝性ニューロパチーおよび関連障害の処置および検出
WO2024064147A1 (en) * 2022-09-20 2024-03-28 Mayo Foundation For Medical Education And Research Treating congenital disorders of glycosylation
WO2025171282A1 (en) * 2024-02-09 2025-08-14 Landry's Smile, Llc Methods for treating congenital disorders of glycosylation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1898897A2 (en) * 2005-07-07 2008-03-19 Sirtris Pharmaceuticals, Inc. Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
US20110257233A1 (en) * 2010-03-19 2011-10-20 Sanford-Burnham Medical Research Institute Benzoisothiazolones as inhibitors of phosphomannose isomerase
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
WO2013123403A1 (en) * 2012-02-15 2013-08-22 Sanford-Burnham Medical Research Institute Theranostics platform and methods of use
RS61239B1 (sr) * 2016-06-21 2021-01-29 Univ Columbia Inhibitori aldozne reduktaze i postupci korišćenja
EP3275863A1 (en) * 2016-07-29 2018-01-31 Universidad Autónoma de Madrid Compounds for treating congenital disorders of glycosylation
IL272246B2 (en) * 2017-07-28 2026-01-01 Applied Therapeutics Inc History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
AU2019326265B2 (en) * 2018-08-20 2025-07-24 Maggie's Pearl, Llc Methods for treating congenital disorders of glycosylation
CA3132136A1 (en) * 2019-04-01 2020-10-08 Andrew Wasmuth Inhibitors of aldose reductase

Also Published As

Publication number Publication date
US20220226323A1 (en) 2022-07-21
IL291946A (en) 2022-06-01
BR112022005895A2 (pt) 2022-06-28
CN114667139B (zh) 2025-03-28
CN120093757A (zh) 2025-06-06
WO2021071965A1 (en) 2021-04-15
CA3153108A1 (en) 2021-04-15
MX2022004270A (es) 2022-05-03
EP4041219A4 (en) 2023-11-01
AU2020363699A1 (en) 2022-05-26
JP2022552831A (ja) 2022-12-20
JP2025100631A (ja) 2025-07-03
JP7778686B2 (ja) 2025-12-02
CN114667139A (zh) 2022-06-24
EP4041219A1 (en) 2022-08-17

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