CN1197975C - 测定多核苷酸序列变异的方法 - Google Patents

测定多核苷酸序列变异的方法 Download PDF

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Publication number
CN1197975C
CN1197975C CNB99809692XA CN99809692A CN1197975C CN 1197975 C CN1197975 C CN 1197975C CN B99809692X A CNB99809692X A CN B99809692XA CN 99809692 A CN99809692 A CN 99809692A CN 1197975 C CN1197975 C CN 1197975C
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CN
China
Prior art keywords
polynucleotide
labeled
watson
labels
template
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Expired - Fee Related
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CNB99809692XA
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English (en)
Chinese (zh)
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CN1312859A (zh
Inventor
E·P·道森
J·A·飞利浦三世
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BioVentures Inc
Vanderbilt University
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BioVentures Inc
Vanderbilt University
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Publication of CN1312859A publication Critical patent/CN1312859A/zh
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Publication of CN1197975C publication Critical patent/CN1197975C/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Error Detection And Correction (AREA)
CNB99809692XA 1998-08-19 1999-08-19 测定多核苷酸序列变异的方法 Expired - Fee Related CN1197975C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9713698P 1998-08-19 1998-08-19
US60/097,136 1998-08-19

Publications (2)

Publication Number Publication Date
CN1312859A CN1312859A (zh) 2001-09-12
CN1197975C true CN1197975C (zh) 2005-04-20

Family

ID=22261392

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB99809692XA Expired - Fee Related CN1197975C (zh) 1998-08-19 1999-08-19 测定多核苷酸序列变异的方法

Country Status (12)

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US (2) US6322988B1 (enExample)
EP (1) EP1105537B1 (enExample)
JP (1) JP3949378B2 (enExample)
CN (1) CN1197975C (enExample)
AT (1) ATE310103T1 (enExample)
AU (1) AU737087C (enExample)
CA (1) CA2336546A1 (enExample)
DE (1) DE69928409D1 (enExample)
IL (1) IL141329A (enExample)
IS (1) IS5847A (enExample)
WO (1) WO2000011221A1 (enExample)
ZA (1) ZA200100124B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040121394A1 (en) * 1998-08-19 2004-06-24 Dawson Elliott P. Method for determining polynucleotide sequence variations
US20030138834A1 (en) * 1998-08-19 2003-07-24 Dawson Elliott P. Method for determining polynucleotide sequence variations
JP2004523243A (ja) * 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
WO2003006692A1 (en) 2001-07-11 2003-01-23 Applera Corporation Internal calibration standards for electrophoretic analyses
WO2003040395A2 (en) 2001-11-07 2003-05-15 Applera Corporation Universal nucleotides for nucleic acid analysis
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US7189512B2 (en) * 2003-02-20 2007-03-13 Noga Porat Methods for variation detection
CA2567591C (en) * 2004-06-10 2011-08-02 Ge Healthcare Bio-Sciences Corp. Method for nucleic acid sequencing in the absence of divalent metal ion
ATE510025T1 (de) * 2005-12-13 2011-06-15 Inst Curie Verfahren für die detektion von mutationen in nukleinsaüren, und die anwendung in der diagnose von genetischen krankheiten und krebs
IT1397110B1 (it) * 2008-12-29 2012-12-28 St Microelectronics Rousset Microreattore autosigillante e metodo per eseguire una reazione
WO2015062184A1 (en) * 2013-11-01 2015-05-07 Accurascience, Llc Method and apparatus for calling single-nucleotide variations and other variations
CN114724628B (zh) * 2022-04-24 2022-11-08 华中农业大学 一种对多物种进行多核苷酸变异鉴定和注释的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5683869A (en) 1993-09-03 1997-11-04 Duke University Method of nucleic acid sequencing
AU2766195A (en) * 1994-06-03 1996-01-05 Brigham And Women's Hospital Identification of polycystic kidney disease gene, diagnostics and treatment
US5830657A (en) * 1996-05-01 1998-11-03 Visible Genetics Inc. Method for single-tube sequencing of nucleic acid polymers
US6432634B1 (en) * 1996-04-18 2002-08-13 Visible Genetics Inc. Method, apparatus and kits for sequencing of nucleic acids using multiple dyes
US5847162A (en) * 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US5928906A (en) * 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US5846727A (en) * 1996-06-06 1998-12-08 Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College Microsystem for rapid DNA sequencing

Also Published As

Publication number Publication date
JP3949378B2 (ja) 2007-07-25
JP2002523062A (ja) 2002-07-30
US6322988B1 (en) 2001-11-27
EP1105537B1 (en) 2005-11-16
AU5681399A (en) 2000-03-14
AU737087C (en) 2005-05-12
IL141329A (en) 2005-07-25
AU737087B2 (en) 2001-08-09
US20020164606A1 (en) 2002-11-07
IL141329A0 (en) 2002-03-10
DE69928409D1 (de) 2005-12-22
ZA200100124B (en) 2001-08-03
ATE310103T1 (de) 2005-12-15
CN1312859A (zh) 2001-09-12
WO2000011221A1 (en) 2000-03-02
EP1105537A1 (en) 2001-06-13
EP1105537A4 (en) 2002-08-14
IS5847A (is) 2001-02-16
CA2336546A1 (en) 2000-03-02
HK1040265A1 (en) 2002-05-31

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Granted publication date: 20050420

Termination date: 20120819