CN119731156A - 依莫帕米结合蛋白抑制剂及其用途 - Google Patents

依莫帕米结合蛋白抑制剂及其用途 Download PDF

Info

Publication number
CN119731156A
CN119731156A CN202380033932.3A CN202380033932A CN119731156A CN 119731156 A CN119731156 A CN 119731156A CN 202380033932 A CN202380033932 A CN 202380033932A CN 119731156 A CN119731156 A CN 119731156A
Authority
CN
China
Prior art keywords
azaspiro
oxa
sulfonyl
alkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380033932.3A
Other languages
English (en)
Chinese (zh)
Inventor
M·希梅尔鲍尔
F·冈萨雷斯洛佩斯德图里索
J·H·琼斯
E·Y·S·林
R·普林斯
V·帕塔罗彭
Z·辛
T·Y·陈
N·班索尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bojian Massachusetts Co ltd
Original Assignee
Bojian Massachusetts Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bojian Massachusetts Co ltd filed Critical Bojian Massachusetts Co ltd
Publication of CN119731156A publication Critical patent/CN119731156A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202380033932.3A 2022-02-14 2023-02-13 依莫帕米结合蛋白抑制剂及其用途 Pending CN119731156A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263309923P 2022-02-14 2022-02-14
US63/309,923 2022-02-14
PCT/US2023/012879 WO2023154499A1 (en) 2022-02-14 2023-02-13 Emopamil-binding protein inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
CN119731156A true CN119731156A (zh) 2025-03-28

Family

ID=85505736

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380033932.3A Pending CN119731156A (zh) 2022-02-14 2023-02-13 依莫帕米结合蛋白抑制剂及其用途

Country Status (5)

Country Link
US (1) US20250152574A1 (https=)
EP (1) EP4479384A1 (https=)
JP (1) JP2025506667A (https=)
CN (1) CN119731156A (https=)
WO (1) WO2023154499A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202523666A (zh) * 2023-08-23 2025-06-16 美商百健Ｍａ公司 依莫帕米結合蛋白抑制劑及其用途
WO2025049275A1 (en) * 2023-08-25 2025-03-06 Biogen Ma Inc. Emopamil-binding protein inhibitors and uses thereof
IL326831A (en) * 2023-08-28 2026-04-01 Genzyme Corp Pyrazolyl compounds as amofamyl-binding protein inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10082496B2 (en) * 2014-09-10 2018-09-25 Board Of Regents Of The University Of Texas System Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis
MA44037B1 (fr) * 2016-06-06 2020-03-31 Arena Pharm Inc Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci

Also Published As

Publication number Publication date
US20250152574A1 (en) 2025-05-15
EP4479384A1 (en) 2024-12-25
WO2023154499A1 (en) 2023-08-17
JP2025506667A (ja) 2025-03-13

Similar Documents

Publication Publication Date Title
JP7033141B2 (ja) メニン－ｍｌｌ相互作用の縮合二環式阻害剤
US8828996B2 (en) Morpholine-spirocyclic piperidine amides as modulators of ion channels
CN119731156A (zh) 依莫帕米结合蛋白抑制剂及其用途
WO2019158019A1 (zh) 嘧啶并环化合物及其制备方法和应用
JP2016034986A (ja) イオンチャネルのモジュレーターとしてのクロマン−スピロ環式ピペリジンアミド
CN115515949A (zh) 新型氨基嘧啶类egfr抑制剂
US20230148214A1 (en) Indazoles and azaindazoles as lrrk2 inhibitors
WO2007057775A1 (en) Spiropiperidine derivatives
CN119156392A (zh) 依莫帕米结合蛋白抑制剂及其用途
TW202438495A (zh) Ｎｌｒｐ３抑制劑
CN119855809A (zh) 依莫帕米结合蛋白抑制剂及其用途
CN115677682A (zh) 螺环类plk4抑制剂及其用途
CN119095845A (zh) 依莫帕米结合蛋白抑制剂及其用途
TW202409039A (zh) 依莫帕米結合蛋白抑制劑及其用途
WO2025043148A1 (en) Emopamil-binding protein inhibitors and uses thereof
JP2025534402A (ja) コレステロール生合成のヒダントインモジュレーターおよび再髄鞘形成を促進するためのその使用
JP2024542296A (ja) コレステロール生合成のスピロ環式モジュレーターおよび再髄鞘形成を促進するためのその使用
JP2025533043A (ja) コレステロール生合成のアゾールモジュレーターおよび再髄鞘形成を促進するためのその使用
HK40008247A (en) Fused bicyclic inhibitors of menin-mll interaction

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination