CN119497629A - 编码组成型活性环状gmp-amp合酶的核酸及其免疫原性递送媒介物 - Google Patents

编码组成型活性环状gmp-amp合酶的核酸及其免疫原性递送媒介物 Download PDF

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Publication number
CN119497629A
CN119497629A CN202380050168.0A CN202380050168A CN119497629A CN 119497629 A CN119497629 A CN 119497629A CN 202380050168 A CN202380050168 A CN 202380050168A CN 119497629 A CN119497629 A CN 119497629A
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composition
lipid
cgas
mrna
antigen
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CN202380050168.0A
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Chinese (zh)
Inventor
E·戈斯林
D·日瓦基
J·周
A·尼基福罗夫
D·森古普塔
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Kona Treatment Co
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Kona Treatment Co
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    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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CN202380050168.0A 2022-05-13 2023-05-12 编码组成型活性环状gmp-amp合酶的核酸及其免疫原性递送媒介物 Pending CN119497629A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263341984P 2022-05-13 2022-05-13
US63/341,984 2022-05-13
PCT/US2023/066975 WO2023220747A1 (en) 2022-05-13 2023-05-12 Nucleic acids encoding a constitutively-active cyclic gmp-amp synthase and immunogenic delivery vehicles for same

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CN119497629A true CN119497629A (zh) 2025-02-21

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CN202380050168.0A Pending CN119497629A (zh) 2022-05-13 2023-05-12 编码组成型活性环状gmp-amp合酶的核酸及其免疫原性递送媒介物

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US (1) US20250255815A1 (enExample)
EP (1) EP4522212A1 (enExample)
JP (1) JP2025516636A (enExample)
KR (1) KR20250022050A (enExample)
CN (1) CN119497629A (enExample)
AU (1) AU2023269866A1 (enExample)
CA (1) CA3258341A1 (enExample)
IL (1) IL316959A (enExample)
TW (1) TW202400253A (enExample)
WO (1) WO2023220747A1 (enExample)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3173092B1 (en) * 2015-04-22 2019-06-26 CureVac AG Rna containing composition for treatment of tumor diseases
EP3814487A4 (en) * 2018-06-29 2022-04-20 President and Fellows of Harvard College STRUCTURE OF THE HUMAN CGAS-DNA COMPLEX AND ITS USES

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AU2023269866A1 (en) 2025-01-02
TW202400253A (zh) 2024-01-01
IL316959A (en) 2025-01-01
EP4522212A1 (en) 2025-03-19
US20250255815A1 (en) 2025-08-14
KR20250022050A (ko) 2025-02-14
WO2023220747A1 (en) 2023-11-16
JP2025516636A (ja) 2025-05-30
CA3258341A1 (en) 2023-11-16

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