CN1194682C - Preparing process and usage of zine taurinate - Google Patents
Preparing process and usage of zine taurinate Download PDFInfo
- Publication number
- CN1194682C CN1194682C CNB01118714XA CN01118714A CN1194682C CN 1194682 C CN1194682 C CN 1194682C CN B01118714X A CNB01118714X A CN B01118714XA CN 01118714 A CN01118714 A CN 01118714A CN 1194682 C CN1194682 C CN 1194682C
- Authority
- CN
- China
- Prior art keywords
- zinc
- taurine
- zine
- preparation
- weighing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 58
- 229960003080 taurine Drugs 0.000 claims abstract description 29
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 45
- 239000011701 zinc Substances 0.000 claims description 26
- 229910052725 zinc Inorganic materials 0.000 claims description 24
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 239000011787 zinc oxide Substances 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 4
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 4
- 229960001763 zinc sulfate Drugs 0.000 claims description 4
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 4
- 235000013373 food additive Nutrition 0.000 claims description 3
- 239000002778 food additive Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000012567 medical material Substances 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000007670 refining Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000011592 zinc chloride Substances 0.000 claims description 2
- 235000005074 zinc chloride Nutrition 0.000 claims description 2
- 235000013305 food Nutrition 0.000 abstract description 5
- 238000005516 engineering process Methods 0.000 abstract description 4
- 210000000170 cell membrane Anatomy 0.000 abstract description 2
- 150000004697 chelate complex Chemical class 0.000 abstract 1
- 230000000050 nutritive effect Effects 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 4
- 239000013522 chelant Substances 0.000 description 4
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000007952 growth promoter Substances 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 108010016626 Dipeptides Proteins 0.000 description 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 229960000314 zinc acetate Drugs 0.000 description 1
- 235000013904 zinc acetate Nutrition 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229940071566 zinc glycinate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940110280 zinc methionine Drugs 0.000 description 1
- 229940091251 zinc supplement Drugs 0.000 description 1
- CNMFGFBWPBBGKX-SCGRZTRASA-L zinc;(2s)-2-amino-4-methylsulfanylbutanoate Chemical compound [Zn+2].CSCC[C@H](N)C([O-])=O.CSCC[C@H](N)C([O-])=O CNMFGFBWPBBGKX-SCGRZTRASA-L 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a preparation method of zine taurine and an application thereof. The zine taurine is a chelate complex with stable property and bioactivity, and is easy to absorb through a cell membrane. The preparation method has reasonable technology, simplicity and wide application to the nutritive intensifiers of food, health-care products, pharmaceutical raw materials, etc.
Description
Technical field
The present invention relates to food additive and medical material, particularly relate to the preparation method and its usage of zinc taurine.
Background technology
At present, the physiological function of trace element zinc and taurine is accepted by people day by day.Zinc alleviates cold symptoms to promoting growth promoter, promotes wound healing, and infection improves vision, and enhancing immunity all has effect in various degree, and the laudatory title of " flower of life " is arranged.Taurine is to promoting the child, and especially the growth promoter of infant brain, height, vision, heart etc. plays an important role.In view of this, both physiological functions are similar, but do not substitute mutually.Food additive about zinc mainly contains zinc sulfate, zinc lactate, zinc gluconate, zinc acetate etc., and absorbance is lower, and moral character is not ideal enough.This is because at small bowel, zinc ion at first homopolypeptide, dipeptides or certain seed amino acid forms chelate, and integral body enters cyton by various cell membrane then, and last chelating chain disconnects, zinc ion is by various enzyme combinations, and forming zinc enzyme aminoacid could be absorbed by organism.In recent years, the food of fortified zinc and taurine, beverage, milk product and nutrient prime replenisher occur in a large number, but these products all are to add isolating taurine and zinc agent simultaneously, though mix, do not have combination.If both are organically added in the food after forming chelate in advance again, its effect will obviously strengthen.What research was more in numerous amino acid trace element chelated things is zinc methionine and zinc glycinate, looks into new proof zinc taurine through the Chinese science and technology information research and belongs to novel organic zinc supplement agent both at home and abroad.
Summary of the invention
Purpose of the present invention just provides a kind of biologically active, both supplementation of taurine, but the amino-acid chelate of reinforced micro-element zinc---zinc taurine again.
Another object of the present invention provides a kind of preparation method and its usage of above-mentioned amino-acid zinc chelate.
Zinc taurine of the present invention is white fine particle or powder, and its molecular formula is: C
4H
12N
2S
2O
6Zn, its structural formula is: Zn[NH
2-CH
2-CH
2-SO
3]
2
Preparation method of the present invention is: take by weighing a certain amount of taurine and add in the suitable quantity of water; heating makes it to dissolve fully; mol ratio according to required configuration; taking by weighing a certain amount of zinc oxide or zinc sulfate more slowly joins in the taurine solution; regulate pH value to certain value with sodium hydroxide solution, be heated to 60～100 ℃ of stirring reactions 1～3 hour, add organic solvents such as proper amount of acetone or ethanol; precipitation is separated out, and refining drying obtains zinc taurine.
In the preparation method of zinc taurine of the present invention, the optimum molar coordination ratio of the complex reaction of taurine and zinc element is 2: 1, and PH is 7, and reaction temperature is 85 ℃, and the zinc source is selected zinc oxide, zinc sulfate or zinc chloride etc. for use, and preferentially selects zinc oxide for use.
The preparation method technology of zinc taurine of the present invention is reasonable, simple and easy to do, and productive rate is up to 90%, and the purity height.
Good effect of the present invention is: zinc taurine dissociate in vivo taurine and zinc ion; participate in physiological metabolism; have no side effect; be the food enrichment that integrates supplementation of taurine and zinc element, can be widely used in the fortification and the uses such as nutrient prime replenisher class health product and medical material of various food, liquid milk, milk powder, beverage etc.
The present invention is described further below in conjunction with embodiment, is limitation of the present invention but should not be construed as.
The specific embodiment
Taking by weighing 25 gram taurines is dissolved in the 200ml water; heating in water bath makes it to dissolve fully; taking by weighing 8.1 gram zinc oxide more slowly joins in the taurine solution; regulate pH value to 7 with 5% sodium hydroxide solution; be heated to 85 ℃ of stirring reactions 1.5 hours; add an amount of ethanol, precipitation is separated out fully, refining drying obtains white zinc taurine powder.
The zinc taurine that makes is joined in the liquid milk, and addition is 100～200mg/kg, can make zinc content reach 3～6mg/100ml, and content of taurine reaches 7～12mg/100ml.The liquid milk product mouthfeel that makes is good, and no bitter taste more adapts to absorption of human body.In addition, also can be made into products such as nutrient prime replenisher.
Claims (1)
1. food additive or medical material are with the preparation method of zinc taurine; it is characterized in that taking by weighing a certain amount of taurine adds in the suitable quantity of water; heating makes it to dissolve fully; mol ratio according to required configuration; taking by weighing a certain amount of zinc oxide, zinc sulfate or zinc chloride more slowly joins in the taurine solution; regulate pH value to 7 with sodium hydroxide solution; be heated to 60～100 ℃ of stirring reactions 1～3 hour; add proper amount of acetone or ethanol; precipitation is separated out; refining dry and make, wherein the mol ratio of the complex reaction of taurine and zinc element is 2: 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB01118714XA CN1194682C (en) | 2001-06-07 | 2001-06-07 | Preparing process and usage of zine taurinate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB01118714XA CN1194682C (en) | 2001-06-07 | 2001-06-07 | Preparing process and usage of zine taurinate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1390540A CN1390540A (en) | 2003-01-15 |
| CN1194682C true CN1194682C (en) | 2005-03-30 |
Family
ID=4663389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB01118714XA Expired - Fee Related CN1194682C (en) | 2001-06-07 | 2001-06-07 | Preparing process and usage of zine taurinate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1194682C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114223908A (en) * | 2021-12-27 | 2022-03-25 | 四川大学 | Mineral trace element and taurine composite product, preparation method and application |
-
2001
- 2001-06-07 CN CNB01118714XA patent/CN1194682C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1390540A (en) | 2003-01-15 |
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Effective date of registration: 20130822 Address after: 100176, Beijing economic and Technological Development Zone, Beijing Hongda Road 12, 2, two or three floor Patentee after: Beijing T&X Biotech Co., Ltd. Address before: 8 box 515, south 2nd Ring Road, Shijiazhuang, Hebei, 050031 Patentee before: Li Weiping |
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