CN1193736C - Medicine for eliminating bromhidrosis - Google Patents
Medicine for eliminating bromhidrosis Download PDFInfo
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- CN1193736C CN1193736C CNB011380284A CN01138028A CN1193736C CN 1193736 C CN1193736 C CN 1193736C CN B011380284 A CNB011380284 A CN B011380284A CN 01138028 A CN01138028 A CN 01138028A CN 1193736 C CN1193736 C CN 1193736C
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- bromhidrosis
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Abstract
The present invention relates to a medicine for treating osmidrosis, which is characterized in that the medicine is prepared from 16% to 33% of clam powder, 3% to 8% of clove, 4% to 16% of white alum and additive as the rest. The present invention has the advantages of favorable antibacterial effect and high cure rate, and has no side effect on human skin.
Description
Technical field
The present invention relates to a kind of medicine, particularly a kind of medicine for eliminating bromhidrosis.
Background technology
In the prior art, the treatment bromhidrosis mainly contains following several method, and a kind of is topical agent, and three kinds of liquid, powder body and mastic are arranged, owing to wherein contain essence, can only hide stink, relief of symptoms can not be eradicated, cause bromhidrosis to be shown effect repeatedly, and the chemical analysis unstable properties that most medicines contain, zest is strong, and patient Chang Yin skin allergy causes skin ulceration and discontinues medication.And other method for example machine inustion, drugs local injection method, surgical excision are bigger to the human injury.
Summary of the invention
The object of the present invention is to provide that a kind of to separate theory of Chinese medical science wet, the conditioning sweat gland with toxin expelling serve as according to the medicine for eliminating bromhidrosis made, the effect that it has the character gentleness, can recover the normal function of body of gland.
Technical scheme of the present invention is: a kind of medicine for eliminating bromhidrosis, and it comprises Pulvis concha Mactrae 16%～33%, Flos Caryophylli 3%～8%, Alumen 4%～16%, all the other are for dosing thing.
The present invention compared with prior art has following advantage:
1, human skin patch
When carrying out human skin patch, can detect and be tried the probability that thing causes the human body skin untoward reaction:
The experimenter: totally 25 people, male 0 people, women 25 people, age 19-24 meets the experimenter and volunteers inclusion criteria.
Patch method: the patch adhesive tape of selecting for use Shanghai Hygienic Material Factory to produce, with closed patch test method, 0.03g of the present invention is applied in the patch device, the external special adhesive tape sticks in the experimenter back, remove after 24 hours and tried thing, patch test 24,48,72 hours (promptly remove tried thing after 0.5,24,48 hour) is observed dermoreaction respectively, two week the back repeated trials once, testing result is: reaction appears in 25 philtrums 0 example, so this is tried thing human body skin is not caused untoward reaction.
2, the present invention is to the influence of sweat secretion
By observing the influence of medicine, investigate the effect of the present invention to sweat secretion to the rat sweat secretion.
(1). experiment material:
Animal: rat, 200 ± 20g, the male and female dual-purpose, Heilongjiang University of Chinese Medicine's Experimental Animal Center provides.
Medicine: aqueous solution of the present invention, 4g/ml, 2g/ml
Experiment material: big rat holder, fixed mount, magnifier
Reagent: distilled water, dehydrated alcohol and Tian Yigao Yuan Shi reagent
(2). experimental technique and content: get 30 of rats, be divided into high dose group (aqueous solution 4g/ml of the present invention), low dose group (aqueous solution 2g/ml of the present invention) and matched group (normal saline) at random, 10 every group.With cotton swab dip in dehydrated alcohol with the foot scrub after, concentration coating every day is 1 time shown in pressing with high dose group, low dose group, continuous 7 days, matched group was coated with normal saline (when smearing big rat being fixed in the holder, in order to avoid bump medicine) every day.After the last administration, rat is faced upward the position is fixed in the holder, expose two back legs (for avoiding in the back leg withdrawal holder, available adhesive tape is fixed on its back leg on the holder gently), with the wiping gently of dried cotton swab, on skin of sole of foot, be coated with then and field-high Yuan Shi reagent A liquid, after treating intensive drying, the very thin again B liquid of coating, naked eyes or magnifier examine darkviolet colored spots (being the antiperspirant point) time of occurrence then, color and quantity, treat that antiperspirant point occurs after, continue to observe 20 minutes, every 5-10 minute record once carries out statistics t check with data after experiment finishes, and compares each group difference.
(3). experimental result: the present invention has obvious inhibitory action to normal rat paw portion sweat secretion, and is concentration dependent.Experimental result sees Table 1.
Table 1 the present invention is to the influence of the normal rat paw portion sweat secretion (n=10 of X ± SD)
Number appears in 1 hour antiperspirant point after the group concentration g/ml administration
High dose group 4+* *
Low dose group 2 ++ * *
Matched group-+++
Compare with matched group
*P＜0.01
(4). experiment conclusion: the present invention has the obvious suppression effect to the normal rat sweat secretion, and the high more inhibitory action of concentration is stronger.
Note: and the compound method of field-high Yuan Shi reagent
A liquid: get iodine 2g, be dissolved in the 100ml dehydrated alcohol.
B liquid: get soluble starch 50g, Oleum Ricini 100ml, mixing gets final product.
3, antibacterial action of the present invention (Plating)
Inoculation variety classes antibacterial on the plate that contains the variable concentrations medicine is judged antibacterial action of the present invention and effect power with the growing state of antibacterial.
(1). experiment material:
Bacterial strain: corynebacterium, staphylococcus aureus, escherichia coli, Bacillus proteus.
Equipment: sterile test tube, test tube rack, plate, pipet, inoculating loop, beaker, conical flask, broth agar culture medium
Medicine: powder body of the present invention is made into the 4g/ml suspension with normal saline
Reagent: normal saline, distilled water.
(2). experimental technique and content:
1. the preparation of Carnis Bovis seu Bubali cream soup agar culture medium: in the 100ml distilled water, add Carnis Bovis seu Bubali cream 0.3g, peptone 1.0g, sodium chloride 0.5g, agar 2.0g, heating for dissolving is regulated its pH value 7.2-7.6 with the 20g/dl sodium hydroxide solution, filter with absorbent cotton or double gauze, be sub-packed in vitro autoclaving (103.4kPa, 20 minutes).
2. the preparation of medicine plating medium: get 5 in test tube of sterilization, number consecutively is arranged on the test tube rack, adds each test tube by aseptic manipulation with pipette, extract physiological saline solution 3ml, draw then the present invention (4g/ml) altogether 3ml put into the 2nd pipe, inhale and spare; Put into the 3rd pipe from the 2nd pipe sucking-off 3ml again ... method according to this is diluted to the 5th pipe by pipe by 2 times, and medicinal liquid is diluted into 2,4,6,8,16 and 32 times successively, promptly is respectively 2,1,0.5,0.25,0.125g/ml.Get 6 aseptic plates, covering label, the 2-6 plate adds the medicinal liquid 2ml that above-mentioned 1-5 test tube has diluted respectively, No. 1 plate adds the medicinal liquid 2ml of end dilution, in each plate, add then and melted and be cooled to broth agar culture medium 18ml about 40 ℃, shake plate immediately, make the abundant mixing of culture medium and medicinal liquid.After treating that it solidifies, promptly make the plating medium that contains medicine, it contains, and concentration of the present invention is respectively 0.4,0.2,0.1,0.05,0.025,0.0125g/ml.
3. inoculation of antibacterial and cultivation: the experimental strain of preserving is inoculated in broth agar culture medium respectively, cultivated 16-18 hour in 37 ℃ of incubators, dip in respectively with inoculating loop and to get experimental bacteria liquid, be inoculated in the zones of different of each pastille flat board with method of scoring, put into 37 ℃ of incubators after planting well and cultivate taking-up after 24 hours, observe antibacterial growing state on variable concentrations medicine flat board, the least concentration that antibacterial is not grown is the MIC (minimum inhibitory concentration) of medicine to this bacterium.
(3). experimental result: see Table 2
Table 2 antibacterial action of the present invention (Plating)
Thalline minimum inhibitory concentration (g/ml) drug dilution degree
Corynebacterium 0.5 1: 8
Staphylococcus aureus 0.125 1: 32
Escherichia coli 0.25 1: 16
Bacillus proteus 0.25 1: 16
(4). experiment conclusion: the present invention has inhibitory action in various degree to above-mentioned four kinds of antibacterials.
4, antibacterial action of the present invention (test tube method)
At the broth agar culture medium of variable concentrations medicine in vitro, can the inoculation experiments strain be cultivated the back and observed antibacterial and grow, and judges minimum inhibitory concentration of the present invention with this.
(1). experiment material:
Bacterial strain: corynebacterium, staphylococcus aureus, escherichia coli, Bacillus proteus.
Equipment: sterilization test tube, test tube rack, pipet, conical flask, inoculating loop, Carnis Bovis seu Bubali cream soup culture medium
Medicine: the aseptic clear filtrate of 1g/ml of the present invention
(2). experimental technique and content:
1. the preparation of Carnis Bovis seu Bubali cream soup body culture medium: get Carnis Bovis seu Bubali cream 0.3g, peptone 1.0g, sodium chloride 0.5g, put into beaker, add distilled water again to 100ml after adding a small amount of distilled water heat fused, regulate its pH value 7.2-7.6 with the 20g/dl sodium hydroxide solution then, use filter paper filtering.Package 103.4kPa (15 pounds) sterilization 20 minutes with conical flask.
2. the preparation of pharmaceutical liquid culture medium: because experimental strain is more, be the formality that simplifies the operation, test with being loaded on small test tube behind the Boiling tube dilute liquid medicine more respectively earlier.Get 10 Boiling tubes, number consecutively by the sterile working, is put in vitro every pipe 5ml with pipette, extract Carnis Bovis seu Bubali cream soup body culture medium.The reuse pipet is inhaled solution of the present invention (1g/ml) 5ml and is put into the 1st pipe, shakes up repeatedly; Then draw 5ml and put into the 2nd pipe, shake up repeatedly from the 1st pipe; The same 5ml that draws puts into the 3rd pipe ... medicinal liquid is diluted as 1: 2 successively, 1: 4,1: 8 ... 1: 1024, drug level was followed successively by 0.5,0.25,0.125 ... 0.001g/ml.Get aseptic small test tube numbering again, every kind of bacterial strain is with 11 test tubes, manages for 1-10 number and to put into successively by serial dilution medicinal liquid 1ml, and No. 11 test tubes are put into the Carnis Bovis seu Bubali cream soup body culture medium 1ml that does not contain medicine and managed in contrast.
3. the inoculation of bacterial strain and cultivation: each experimental strain is inoculated in the Carnis Bovis seu Bubali cream soup body culture medium, in 37 ℃ of incubators, cultivated 16-18 hour, be diluted to 1/1000 concentration with Carnis Bovis seu Bubali cream soup body culture medium.Every kind of bacterial strain suspension inoculates 11 test tubes (containing 1 of 19 of variable concentrations medication tube and control tube), and every pipe 0.1ml cultivated 24 hours in 37 ℃ of incubators, took out the bacterial growth situation of observing.As the drug liquid tube clarification, represent no bacterial growth, then this pipe medicine has antibacterial action: as for muddy, represent that antibacterial has grown, this pipe Chinese medicine does not have antibiotic effect.With the lowest concentration of drug of integral asepsis growth as the MIC of medicine to this bacterial strain.
(3), experimental result: see Table 3
Table 3 antibacterial action of the present invention (test tube method)
Thalline minimum inhibitory concentration (g/ml) drug dilution degree
Corynebacterium 0.5 1: 2
Staphylococcus aureus 0.125 1: 8
Escherichia coli 0.25 1: 4
Bacillus proteus 0.25 1: 4
(4). experiment conclusion: the present invention has inhibitory action in various degree to above-mentioned four kinds of antibacterials.
5, clinical use effect of the present invention
With 20 people is example, uses patient's clinical manifestation situation of the present invention as follows:
In the middle of 20 people, patients with mild accounts for 4 people, moderate 10 people, severe 6 people.
Use the present invention one to two day continuously, light, moderate patient's bromhidrosis flavor disappears, and severe patient's bromhidrosis flavor also obviously subtracts light; Wherein the phenomenon of itching appears in 1 people's armpit, after stopping using 2 days, recovers normal, can continue to use again.After using a week, patients with mild is thoroughly removed bromhidrosis, and the abnormal secretion thing comes off; 6 people's armpit frees from extraneous odour are arranged among the moderate patient, the dry and comfortable no foreign body in surface need not to continue to use to get final product again, and all the other 4 people continue to use for one, two week (about 30 gram dosage) again, the bromhidrosis eradication rate reaches 90%, for the severe patient, life cycle is longer relatively, after one month (about 60 gram dosage), 5 people are reflected well, sweat gland secretion is normal, and foreign body comes off, and eradication rate reaches more than 85%.
The specific embodiment:
A kind of medicine for eliminating bromhidrosis, it comprises Plumbum preparatium 1.5%～2.5%, Pulvis concha Mactrae 16%～33%, Flos Caryophylli 3%～8%, Alumen 4%～16%, all the other are for dosing thing.
The described thing of dosing is Jin Mengshi, and it is 33%～41% that described gold covers stone, and the described thing of dosing also can be Gypsum Fibrosum or Talcum.
The alleged proportioning of the present invention all is weight percentage.
Claims (5)
1, a kind of underarm odour-removing powder is characterized in that: it comprises Pulvis concha Mactrae 16%～33%, Flos Caryophylli powder 3%～8%, Alumen powder 4%～16%, and all the other are for dosing the thing powder.
2, underarm odour-removing powder according to claim 1 is characterized in that: it also comprises Plumbum preparatium powder 1.5%～2.5%.
3, underarm odour-removing powder according to claim 1 is characterized in that: the described thing powder of dosing covers stone powder for gold.
4, underarm odour-removing powder according to claim 1 is characterized in that: the described thing powder of dosing is a Gypsum Fibrosum powder.
5, underarm odour-removing powder according to claim 1 is characterized in that: the described thing powder of dosing is a Pulvis Talci.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011380284A CN1193736C (en) | 2001-12-20 | 2001-12-20 | Medicine for eliminating bromhidrosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011380284A CN1193736C (en) | 2001-12-20 | 2001-12-20 | Medicine for eliminating bromhidrosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1426778A CN1426778A (en) | 2003-07-02 |
| CN1193736C true CN1193736C (en) | 2005-03-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011380284A Expired - Fee Related CN1193736C (en) | 2001-12-20 | 2001-12-20 | Medicine for eliminating bromhidrosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1193736C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550301B (en) * | 2013-10-29 | 2016-01-20 | 张道平 | A kind of preparation being used for the treatment of bromhidrosis |
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2001
- 2001-12-20 CN CNB011380284A patent/CN1193736C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1426778A (en) | 2003-07-02 |
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