CN119286934A - 用于修饰scn9a或scn10a基因的基因编辑系统及其使用方法 - Google Patents

用于修饰scn9a或scn10a基因的基因编辑系统及其使用方法 Download PDF

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Publication number
CN119286934A
CN119286934A CN202411288993.7A CN202411288993A CN119286934A CN 119286934 A CN119286934 A CN 119286934A CN 202411288993 A CN202411288993 A CN 202411288993A CN 119286934 A CN119286934 A CN 119286934A
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Prior art keywords
gene editing
editing system
gene
grna
cells
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CN202411288993.7A
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English (en)
Chinese (zh)
Inventor
S·萨伊曼
S·卡哈兰
A·耶恩
S·埃斯帕诺拉
S·J·斯宾塞
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of CN119286934A publication Critical patent/CN119286934A/zh
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CN202411288993.7A 2019-04-12 2020-04-10 用于修饰scn9a或scn10a基因的基因编辑系统及其使用方法 Pending CN119286934A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962833523P 2019-04-12 2019-04-12
US62/833,523 2019-04-12
CN202080038231.5A CN113994009B (zh) 2019-04-12 2020-04-10 用于修饰scn9a或scn10a基因的基因编辑系统及其使用方法
PCT/US2020/027690 WO2020210640A1 (en) 2019-04-12 2020-04-10 Gene-editing systems for modifying a scn9a or scn10a gene and methods of use thereof

Related Parent Applications (1)

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CN202080038231.5A Division CN113994009B (zh) 2019-04-12 2020-04-10 用于修饰scn9a或scn10a基因的基因编辑系统及其使用方法

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CN119286934A true CN119286934A (zh) 2025-01-10

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CN202411288993.7A Pending CN119286934A (zh) 2019-04-12 2020-04-10 用于修饰scn9a或scn10a基因的基因编辑系统及其使用方法
CN202080038231.5A Active CN113994009B (zh) 2019-04-12 2020-04-10 用于修饰scn9a或scn10a基因的基因编辑系统及其使用方法

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US (1) US20200354741A1 (enExample)
EP (1) EP3953460A1 (enExample)
JP (2) JP2022526670A (enExample)
KR (2) KR20210151110A (enExample)
CN (2) CN119286934A (enExample)
AU (1) AU2020272031B2 (enExample)
BR (1) BR112021020406A2 (enExample)
CA (1) CA3136700A1 (enExample)
CO (1) CO2021014015A2 (enExample)
EA (1) EA202192806A1 (enExample)
IL (2) IL328663A (enExample)
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MX (3) MX2021012493A (enExample)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240366680A1 (en) * 2021-08-16 2024-11-07 Editas Medicine, Inc. Treatment of pain
EP4731643A2 (en) * 2023-06-26 2026-04-29 Navega Therapeutics, Inc. Compositions and methods for reducing pain and inflammation through epigenetic modulation
AU2025207849A1 (en) * 2024-01-11 2026-07-16 Regeneron Pharmaceuticals, Inc. Viral particles retargeted to nervous system tissues
WO2025153066A1 (zh) * 2024-01-19 2025-07-24 云合智药（苏州）生物科技有限公司 用于抑制钠电压门控通道α亚基10(SCN10A)基因表达的核酸及其用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201418713D0 (en) * 2014-10-21 2014-12-03 Kymab Ltd Bindings Proteins
WO2016205759A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
EP3481857B1 (en) * 2016-07-06 2026-02-11 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
EP4650364A3 (en) * 2016-07-06 2026-01-21 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
WO2018165504A1 (en) * 2017-03-09 2018-09-13 President And Fellows Of Harvard College Suppression of pain by gene editing

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MX2021012493A (es) 2022-01-06
WO2020210640A1 (en) 2020-10-15
AU2020272031B2 (en) 2026-08-06
AU2020272031A1 (en) 2021-11-18
IL328663A (en) 2026-07-01
JP2025118676A (ja) 2025-08-13
IL287149A (en) 2021-12-01
CO2021014015A2 (es) 2021-10-29
EP3953460A1 (en) 2022-02-16
SG11202111270SA (en) 2021-11-29
MX2026003964A (es) 2026-05-04
KR20210151110A (ko) 2021-12-13
EA202192806A1 (ru) 2022-02-03
KR20250134148A (ko) 2025-09-09
MX2026003965A (es) 2026-05-04
JP2022526670A (ja) 2022-05-25
JOP20210276A1 (ar) 2023-01-30
US20200354741A1 (en) 2020-11-12
BR112021020406A2 (pt) 2021-12-07
CN113994009B (zh) 2025-05-06
CA3136700A1 (en) 2020-10-15
CN113994009A (zh) 2022-01-28

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