CN118891364A - 用于抑制pnpla3表达的rnai构建体及其使用方法 - Google Patents

用于抑制pnpla3表达的rnai构建体及其使用方法 Download PDF

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Publication number
CN118891364A
CN118891364A CN202380028634.5A CN202380028634A CN118891364A CN 118891364 A CN118891364 A CN 118891364A CN 202380028634 A CN202380028634 A CN 202380028634A CN 118891364 A CN118891364 A CN 118891364A
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China
Prior art keywords
rnai construct
pnpla
nucleotides
antisense strand
seq
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Pending
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CN202380028634.5A
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Chinese (zh)
Inventor
B·米德
J·K·默里
I·拉利夫森
O·霍曼
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Amgen Inc
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Amgen Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

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  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202380028634.5A 2022-03-23 2023-03-21 用于抑制pnpla3表达的rnai构建体及其使用方法 Pending CN118891364A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263322845P 2022-03-23 2022-03-23
US63/322845 2022-03-23
PCT/US2023/064765 WO2023183801A2 (en) 2022-03-23 2023-03-21 Rnai constructs for inhibiting pnpla3 expression and methods of use thereof

Publications (1)

Publication Number Publication Date
CN118891364A true CN118891364A (zh) 2024-11-01

Family

ID=88102183

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CN202380028634.5A Pending CN118891364A (zh) 2022-03-23 2023-03-21 用于抑制pnpla3表达的rnai构建体及其使用方法

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Country Link
US (1) US20250207138A1 (https=)
EP (1) EP4496893A2 (https=)
JP (1) JP2025512771A (https=)
KR (1) KR20240162559A (https=)
CN (1) CN118891364A (https=)
AR (1) AR128877A1 (https=)
AU (1) AU2023237880A1 (https=)
CA (1) CA3254112A1 (https=)
CL (1) CL2024002802A1 (https=)
IL (1) IL315078A (https=)
MX (1) MX2024011595A (https=)
TW (1) TW202345869A (https=)
WO (1) WO2023183801A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025252063A1 (zh) * 2024-06-04 2025-12-11 正大天晴药业集团股份有限公司 靶向pnpla3的双链核糖核酸

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2976445A1 (en) * 2015-02-13 2016-08-18 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
TW202542311A (zh) * 2018-09-19 2025-11-01 美商Ionis製藥公司 Pnpla3表現之調節劑

Also Published As

Publication number Publication date
IL315078A (en) 2024-10-01
MX2024011595A (es) 2024-11-08
US20250207138A1 (en) 2025-06-26
AU2023237880A1 (en) 2024-09-12
TW202345869A (zh) 2023-12-01
CL2024002802A1 (es) 2025-02-07
AR128877A1 (es) 2024-06-19
JP2025512771A (ja) 2025-04-22
KR20240162559A (ko) 2024-11-15
EP4496893A2 (en) 2025-01-29
WO2023183801A2 (en) 2023-09-28
WO2023183801A3 (en) 2023-11-02
CA3254112A1 (en) 2023-09-28

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