CN118804742A - 包含抗微生物剂的小管内插入物 - Google Patents

包含抗微生物剂的小管内插入物 Download PDF

Info

Publication number
CN118804742A
CN118804742A CN202380023636.5A CN202380023636A CN118804742A CN 118804742 A CN118804742 A CN 118804742A CN 202380023636 A CN202380023636 A CN 202380023636A CN 118804742 A CN118804742 A CN 118804742A
Authority
CN
China
Prior art keywords
insert
sustained release
besifloxacin
release biodegradable
hydrogel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380023636.5A
Other languages
English (en)
Chinese (zh)
Inventor
C·D·布里扎德
A·德赛
M·古德斯特恩
M·普利埃姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serpus Ophthalmology Co
Original Assignee
Serpus Ophthalmology Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serpus Ophthalmology Co filed Critical Serpus Ophthalmology Co
Publication of CN118804742A publication Critical patent/CN118804742A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202380023636.5A 2022-01-09 2023-01-06 包含抗微生物剂的小管内插入物 Pending CN118804742A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263297778P 2022-01-09 2022-01-09
US63/297,778 2022-01-09
PCT/US2023/010321 WO2023133278A1 (en) 2022-01-09 2023-01-06 Intracanalicular insert comprising an antimicrobial agent

Publications (1)

Publication Number Publication Date
CN118804742A true CN118804742A (zh) 2024-10-18

Family

ID=87074150

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380023636.5A Pending CN118804742A (zh) 2022-01-09 2023-01-06 包含抗微生物剂的小管内插入物

Country Status (6)

Country Link
US (1) US20250114373A1 (cg-RX-API-DMAC7.html)
EP (1) EP4460286A4 (cg-RX-API-DMAC7.html)
JP (1) JP2025504386A (cg-RX-API-DMAC7.html)
CN (1) CN118804742A (cg-RX-API-DMAC7.html)
CA (1) CA3246246A1 (cg-RX-API-DMAC7.html)
WO (1) WO2023133278A1 (cg-RX-API-DMAC7.html)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8415342B2 (en) * 2008-10-29 2013-04-09 Bausch & Lomb Incorporated Besifloxacin ophthalmic composition for the treatment or control of infection
EP4279064A3 (en) * 2015-05-12 2024-02-28 Incept, LLC Drug delivery from hydrogels
AU2020262932B2 (en) * 2019-04-25 2025-11-13 Ocular Therapeutix, Inc. Intracanalicular hydrogel inserts for the delivery of anesthetics
PT3884929T (pt) * 2020-03-25 2023-08-09 Ocular Therapeutix Inc Implante ocular contendo um inibidor da tirosina cinase
EP4216929A1 (en) * 2020-09-24 2023-08-02 Ocular Therapeutix, Inc. Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent

Also Published As

Publication number Publication date
CA3246246A1 (en) 2023-07-13
EP4460286A4 (en) 2025-12-31
EP4460286A1 (en) 2024-11-13
WO2023133278A1 (en) 2023-07-13
US20250114373A1 (en) 2025-04-10
JP2025504386A (ja) 2025-02-12

Similar Documents

Publication Publication Date Title
US20260053735A1 (en) Ocular hydrogel tyrosine kinase inhibitor implants
KR102893953B1 (ko) 하이드로겔 및 사이클로스포린을 포함하는 지속 방출 생분해성 소관내 삽입체
WO2012112636A1 (en) Cylindrical ocular inserts
WO2012112638A1 (en) Cross reference to related applications
KR20240119275A (ko) 압출된 안구 삽입물 또는 이식물 및 이들의 방법
JP2023542939A (ja) ヒドロゲル及び活性薬剤を含む徐放性生分解性小管内挿入物
JP2025513338A (ja) ｉｎ ｓｉｔｕで形成された共有結合を有する単一溶液ハイドロゲル、該ハイドロゲルを使用する組成物設計及び医療処置
US12453724B2 (en) Ocular implant containing a tyrosine kinase inhibitor
US20250114373A1 (en) Intracanalicular insert comprising an antimicrobial agent
US20250064760A1 (en) Intracanalicular insert comprising a non-steroidal anti-inflammatory agent
EP4142664A1 (en) Methods of treating allergic conjunctivitis
CN118591369A (zh) 挤出式眼部插入物或植入物及其方法
CN116133664A (zh) 含有糖皮质激素的眼部插入物
HK40090731A (zh) 包含水凝胶和环孢菌素的持续释放可生物降解泪小管内插入物
US20220183969A1 (en) Ocular insert containing a glucocorticoid
HK40085774A (en) Methods of treating allergic conjunctivitis

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination