CN1187066C - antiatherosclerosis medicine - Google Patents
antiatherosclerosis medicine Download PDFInfo
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- CN1187066C CN1187066C CNB021135320A CN02113532A CN1187066C CN 1187066 C CN1187066 C CN 1187066C CN B021135320 A CNB021135320 A CN B021135320A CN 02113532 A CN02113532 A CN 02113532A CN 1187066 C CN1187066 C CN 1187066C
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Abstract
The present invention provides a medicine for resisting atherosclerosis, which comprises 30 to 300 parts by weight of mulberry bark, 30 to 50 parts by weight of eucommia bark, 10 to 20 parts by weight of ginseng, 20 to 50 parts of acanthopanax, 20 to 30 parts by weight of Japanese snailseed root, and 20 to 30 parts by weight of Chinese date. The medicine of the present invention has optimal effect on treating cardiovascular and cerebrovascular disease and resisting atherosclerosis.
Description
Technical field:
What the present invention relates to is a kind of medicine for the treatment of cardiovascular disease, particularly be a kind of Antiatherosclerosis medicine.
Background technology:
Cardiovascular and cerebrovascular disease is global common, frequently-occurring disease, causes atherosclerosis, causes apoplexy, myocardial infarction.Be used for the treatment of the effect that the common medicine of cardiovascular and cerebrovascular disease such as nifedipine, aspirin, verticil etc. also can only play blood vessel dilating, alleviate disease at present, and can not vessel softening, play antiatherogenic effect.Atherosclerosis is still to fail the difficult medical problem that satisfactorily resolves in the world.
Summary of the invention:
The objective of the invention is in order to overcome above deficiency, a kind of cardiovascular and cerebrovascular disease, good Antiatherosclerosis medicine of atheroma effect for the treatment of is provided.
Antiatherosclerosis medicine of the present invention is made by following raw material by weight:
Cortex Mori 30～300
The Cortex Eucommiae 20～50
Radix Ginseng 10～20
CORTEX ACANTHOPANACIS 20～50
Radix cocculi laurifolii 20～30
Fructus Jujubae 20～30.
Principal agent Cortex Mori in the medicine of the present invention, the Cortex Eucommiae have the function of blood circulation promoting and blood stasis dispelling, toxin expelling antiinflammatory, damp eliminating detumescence, join Radix Ginseng, CORTEX ACANTHOPANACIS, Radix cocculi laurifolii, Fructus Jujubae, invigorating the liver and kidney, bone and muscle strengthening, dissolve platelet, softening arteriosclerosis has unique curative effect to treating various cardiovascular and cerebrovascular vessel chronic diseases.The medicine for preparing is added suitable quantity of water be brewed into Antiatherosclerosis medicine of the present invention.Except that common boiling method, can also be with the conventional manufacture method of Chinese patent medicine, with concentrated electuary or the dosage forms such as tablet, pill or granular preparation made of medicine.
Medicine of the present invention has no side effect through toxicological experiment.Defend department of pathology of institute in Peking University's public affairs and made " the zooperal pathological observation of Antiatherosclerosis medicine ", make animal model with the biochemical heredity of U.S. Rockefeller University with lipoprotein E. (Apoe) the genetic flaw mice that the metabolism laboratory provides, PRELIMINARY RESULTS shows (the results are shown in Table 1, table 2): after treatment, the aortic tunica intima foam cell significantly reduces, and its produce effects result reaches present world medicine top standard.
Result: aortic root inner membrance pathological changes:
Table 1 sxemiquantitative is observed:
It is male female to divide into groups
1 2 3 4 5 1 2 3 4 5
A ++ ++ ++ + ++ ++ ++ + ++ ++
B + + + + + ++ ++ + ++ +
C + - - + - + - + + -
Table 2: foam cell counting (individual/the aorta cross section).
It is male female to divide into groups
1 2 3 4 5 1 2 3 4 5
A 120 97 94 15 113 118 105 16 110 25
B
* 16 3 11 12 4 87 80 5 96 8
*B group (medicine group) is compared with A group (positive controls):
X±SD 81.3±44.0 32.2±38.7
t 2.65
P ＜0.05
C 12 0 0 7 5 9 0 4 3 0
Conclusion:
Antiatherosclerosis medicine has the effect of anti-ApoE genetic flaw mice atherosclerotic lesion.
Medicine invigorating the liver and kidney of the present invention, bone and muscle strengthening, dissolve platelet, blood circulation promoting and blood stasis dispelling, toxin expelling antiinflammatory, damp eliminating detumescence, purify the blood, softening arteries, make blood vessel recover elasticity, make that blood fat, blood are sticking, cholesterol, triglyceride, etc. recover normal, eliminating evilly remove disease, treating both the principal and secondary aspects of a disease, vessel softening, the various cardiovascular and cerebrovascular vessel chronic diseases of treatment are had the curative effect of uniqueness, the atherosclerosis effect is good.Remove the hardship that the patient takes medicine for a long time, life lengthening.Medicine of the present invention has been broken through present medical circle does not have specific drug to the healing cardiovascular and cerebrovascular disease situation.
The specific embodiment:
Embodiment 1:
Get Cortex Mori 30 gram, the Cortex Eucommiae 20 grams, CORTEX ACANTHOPANACIS 20 grams, Radix cocculi laurifolii 20 grams, Radix Ginseng 10 grams, Fructus Jujubae 20 grams, add the water of 10 times of dosages, the temperature fire decocted 2 hours, 200 gram Antiatherosclerosis medicines.This is a dose, once takes.
Embodiment 2:
Get Cortex Mori 100 gram, the Cortex Eucommiae 30 grams, CORTEX ACANTHOPANACIS 30 grams, Radix cocculi laurifolii 25 grams, Radix Ginseng 10 grams, Fructus Jujubae 20 grams, the water temperature fire that adds 10 times of dosages decocted 2 hours, 500 gram Antiatherosclerosis medicines.This is a dose, takes at twice.
Embodiment 3:
Get Cortex Mori 200 gram, the Cortex Eucommiae 50 grams, CORTEX ACANTHOPANACIS 30 grams, Radix cocculi laurifolii 20 grams, Radix Ginseng 10 grams, Fructus Jujubae 20 grams, the water temperature fire that adds 10 times of dosages decocted 2 hours, 250 gram Antiatherosclerosis medicines.This is a dose, and patient obeys potion every day, serve on 5～7 days, and is evident in efficacy.
Embodiment 4:
Get Cortex Mori 300 gram, the Cortex Eucommiae 50 grams, CORTEX ACANTHOPANACIS 50 grams, Radix cocculi laurifolii 30 grams, Radix Ginseng 20 grams, Fructus Jujubae 30 grams, the water temperature fire that adds 10 times of dosages decocted 2 hours, 1000 gram Antiatherosclerosis medicines.This is a dose, divides and takes for three times.
Embodiment 5:
Press Cortex Mori 300 grams, the Cortex Eucommiae 50 grams, Radix Ginseng 20 grams, CORTEX ACANTHOPANACIS 30 grams, Radix cocculi laurifolii 30 grams, Fructus Jujubae 30 gram batchings.The Cortex Mori grating is added water boil twice, add for the first time 10 times the water boil 3 hours of dosage.After medicinal liquid taken out, add 5 times water of dosage for the second time again, the medicinal liquid that boils after 1.5 hours the 1st time, the 2nd time merges.The concentrated solution that is concentrated into relative density 1.10～1.12 (90 ℃) is standby.Get 5 flavor medicines such as the Cortex Eucommiae, it with alcoholic degree 80% alcohol heat reflux secondary, the 8 times of alcohol refluxs 2.5 hours that add for the first time dosage, add for the second time 5 times of amount alcohol refluxs 1.5 hours, merge backflow, filter to reduce to and reclaim ethanol and concentrated solution concentrated solution to relative density 1.12～1.14 (80 ℃), merge two kinds of concentrated solutions, it is an amount of to add dextrin, stirs evenly, is spray dried to graininess under 60 ℃ of temperature, packs by every bag 15g aluminium plastic bag to get final product.
Claims (1)
1, Antiatherosclerosis medicine is characterized in that being made by following raw material by weight:
Cortex Mori 30～300
The Cortex Eucommiae 20～50
Radix Ginseng 10～20
CORTEX ACANTHOPANACIS 20～50
Radix Cocculi Orbiculati 20～30
Fructus Jujubae 20～30
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021135320A CN1187066C (en) | 2002-03-29 | 2002-03-29 | antiatherosclerosis medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021135320A CN1187066C (en) | 2002-03-29 | 2002-03-29 | antiatherosclerosis medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1448158A CN1448158A (en) | 2003-10-15 |
| CN1187066C true CN1187066C (en) | 2005-02-02 |
Family
ID=28680575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021135320A Expired - Fee Related CN1187066C (en) | 2002-03-29 | 2002-03-29 | antiatherosclerosis medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1187066C (en) |
-
2002
- 2002-03-29 CN CNB021135320A patent/CN1187066C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1448158A (en) | 2003-10-15 |
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