CN1187041C - Slow released parts of volatile medicine and air conditioner using same - Google Patents

Abstract

Slow released parts of volatile medicine are provided, having a liquid absorber for absorbing and holding the liquid medicine, a vaporizing quantity control film which controls the vaporizing quantity of the medicine and a humidity-sensitive film which changes in permeating quantity of the medicine in accordance with temperature changes on its surface. The absorber also has a space in which the vaporized vapor of the medicine stays between the films. The member gradually discharges the vapor of the medicine staying in the space formed of the films to the outside through the humidity-sensitive film in accordance with the change of the external humidity environment while the concentration of the vapor in the space is maintained at a fixed value or lower.

Description

Slow released parts of volatile medicine

Technical field

The present invention relates to the slow released parts of volatile medicine that the variation along with outside humidity environment slowly discharges volatile medicine, can be widely used in and prevent under seasonal move or this place atmosphere gas humidity environment change among mycete, the vegetative every field.For example also can be used for bathroom, dressing cubicle, geta cabinet, food cabinet, storeroom, underground storehouse or building idle call humidification path, ventilation path etc.After particularly making the indoor set cooling operation of air conditioner, can often be maintained in the clean condition effectively.

Prior art

The multiple long-time technology that slowly discharges of liquid that makes filling has been proposed so far.Conventional method is to make to contain to be immersed in to utilize capillarity to make it slowly to volatilize in the porous material.Described porous material is inorganic compound such as zeolite, silica gel, or polypropylene, polyester, cellulosic foaming body or fibre bundle.In addition, open the spy and also proposed a kind of containing in flat 5-176733 communique and the flat 6-40890 communique of Te Kai and be called as in the cyclodextrin Organic substance aperture method that slowly discharges.And a kind of method that slow-releasing is specialized with microencapsulation form, also open flat 6-9377 communique, spy and open flat 6-65064 communique, spy and open flat 7-89848 communique, spy and open flat 9-911 communique, spy and open flat 9-12447 communique, spy and open proposition in the flat 9-57091 communique etc. the spy.

And open in clear 55-57502 communique and the clear 63-240738 communique of Te Kai etc. the spy, proposed to inhale in the use under the situation of body, go up with heater heating and to inhale body evaporation rate is further improved, with this as the method that can fully use in insect protected repellent or aromatic field.

These existent method are owing to there not being the humidity environment according to the outside that volatile medicine is slowly discharged, so a kind of method of utilizing the viscose rayon film that volatile medicine is slowly discharged of propositions such as the inventor.

Above-mentioned existing methods constitutes, and can not change according to the humidity environment of outside to make light-concentration volatile medicament slow release stably.The medicament liquid measure is many, and the volatile quantity of initial stage medicament is also many, but As time goes on pharmaceutical quantities reduces gradually, and burst size has the trend that reduces gradually, thereby the problem of volatile quantity or burst size inequality is arranged.And above-mentioned existing program differs greatly between the burst size of low-humidity environment and high humidity environment 3～6 times, and medicament burst size characteristic is also low in the zone line.Therefore there is the danger a little less than the mycete that 60% relative humidity level is grown down suppresses effect.Thereby the burst size characteristic of a kind of medicament of expectation exploitation had linear volatile slow released parts originally with respect to humidity.

Summary of the invention

In view of this problem that exists in the prior art, the object of the invention is to provide a kind of can make slow released parts of volatile medicine that the medicament steam slowly discharges equably and the air conditioner that uses this material under the low concentration rate of release, since can with humidity change fully corresponding, so can suppress when not required unnecessary release.

And the present invention also is to provide a kind of slow released parts of volatile medicine, and the structure of this material can make fugitive constituent secondary from material slowly discharge, and is also unaffected even the medicament liquid measure reduces burst size.

The present invention also is to provide a kind of slow released parts of volatile medicine in addition, and this material effectively utilizes medicament by improving with respect to the linear burst size characteristic from low humidity to the high humility atmosphere gas, to humidity sensitive and have phenomenon burst size characteristic.

The present invention relates to a kind of slow released parts of volatile medicine, have the liquid absorbent material that absorbs the maintenance liquid preparation; The volatile quantity controlling diaphragm of the described medicament volatile quantity of control in the described liquid absorbent material outer package; And the humidity sensing film that changes with humidity of described medicament transmitance, the space segment that evaporable described medicament steam is detained usefulness is set between described volatile quantity controlling diaphragm and described humidity sensing film, make the volatilization of described medicament and in described space segment, remain on below certain vapor concentration, the described medicament that is trapped in the described space segment is changed according to outside humidity environment slowly discharge to the outside from described humidity sensing film; Described liquid absorbent material is the continuous multi-hole body of polyurethane, polypropylene, polyethylene or polyvinyl alcohol, described volatile quantity controlling diaphragm is polyethylene film, polypropylene screen, polyurethane film, nylon membrane, polyethylene terephthalate film or its composite laminate film, and described humidity sensing film is that the surface comprises the laminated construction that the viscose rayon converted paper forms.

By above-mentioned formation, volatile medicine is by maintenance that liquid absorbent material absorbs, under any circumstance can both be corresponding with the orientation of slow released parts of volatile medicine, the volatile quantity of medicament steam is by a controlling diaphragm control concentration that is arranged on the outer package surface, and evaporable composition is full of and is trapped in and has in certain volumetrical space segment.When outside humidity was low, the medicament steam that is full of by this space segment then finally was controlled at substantially below the saturated vapour pressure CONCENTRATION STATE, thereby can be suppressed the burst size of slow released parts of volatile medicine to the outside if do not discharge to the outside.And when outside humidity was high, the humidity sensing film that the medicament steam that volatilization is full of sees through as the secondary controlling diaphragm can discharge to the outside.So just can provide a kind of volatile medicine steam according to the humidity situation from the high concentration space segment discharge low concentration medicament steam, have good volatile medicament slow released parts.Specifically, can under 30 ℃ and 95% relative humidity, reach the purpose that discharges 100 milligrams of/day levels effectively.And medicament steam owing to adopt makes it to volatilize to the space segment that once had been full of and is detained, and then the secondary slow release diffusion way that discharges to the outside, so even the medicament liquid measure reduces variation gradually, concentration can be controlled by vapor liquid equilibrium between space segment in the liquid level of liquid absorbent material and controlling diaphragm.Therefore, owing to the volume that is formed space segment by controlling diaphragm and secondary controlling diaphragm changes the maximum space volume that produces greater than a controlling diaphragm inside because of the medicinal liquid liquid measure, thus can with certain degree reduce slow released parts of volatile medicine release medicine vapor concentration through the time variable quantity.

Best, liquid absorbent material is a continuous multi-hole body, and is greater than 200% slow released parts of volatile medicine to the volume swelling rate of medicament.

By means of above-mentioned formation, can fully absorb the maintenance medicament when using the high continuous multi-hole body of frothing percentage, become the shape that volume increases after the swelling.In this case, when reducing because of volatilization quantity, medicament can utilize visualization to recognize the variation of liquid measure simply.

And if the average pore diameter of the continuous multi-hole body of liquid absorbent material is set in 10～100 microns, the porosity was set in 50～90% o'clock, and the liquid conservation rate of medicament will reach more than 100% in volumetric ratio, thereby can obtain sufficient swelling effect.

In addition, liquid absorbent material can guarantee that then continuous multi-hole body has abundant liquid-maintaining capacity if adopt continuous multi-hole bodies such as polyurethane, polypropylene, polyethylene or polyvinyl alcohol, and is also no problem even the setting of material and orientation change in the practicality.Even the long-time actual practical original form that also can keep continuous multi-hole body shrinks because of medicament residual liquid quantitative changeization is accompanied by gradually, simultaneously so user can simple visual identification medicament residual liquid amount.

As a controlling diaphragm of volatile quantity controlling diaphragm, use polyethylene film, polypropylene screen, polyurethane film, nylon membrane, polyethylene terephthalate film or its composite laminate film, can obtain sufficient slow release effect.

And use with under allyl isosulfocyanate, tea tree oil, the situation of Eucalyptus oil as medicament, can provide and utilize the antibiotic and anti-mold effect that is of value to environment natural component, low concentration.

Use comprises the laminated construction humidity sensing film that the viscose rayon converted paper is made, and a kind of humidity sensing film to humidity sensitive can be provided.

And if 30 ℃ and 95% relative humidity medicament burst size down is set in 20～200 milligrams/day, then can with level release below the human threshold value equal extent, can be to the end user with sound impression.

In addition, if the medicament burst size under 30 ℃ and 30% relative humidity is set in below 30 milligrams/day, then owing under the low humidity condition, controlling the release of no with medicament, so can prolong the replacement cycle.

In addition,, for example use the liquid measure of the enough visual simple identification medicaments of transparent vessel energy, make the end user can know the replacement cycle in order to make inner liquid measure visual.

And in the upper surface of humidity sensing film deposited non-permeability film divests non-permeability film humidity sensing film is exposed as outer packaging bag during use, a kind of bottom line packaged configuration to slow released parts of volatile medicine necessity can be provided under this structure.

The invention still further relates to a kind of air conditioner in addition, is to have heat exchanger at least and using the indoor set of fan through regulating wind to the indoor temperature that is blown into from described heat exchanger, at described indoor set upstream side described slow released parts of volatile medicine is being set.

By this formation, can suppress the low useless release of medicament in season of humidity, in high season of humidity or can be with low concentration release medicine continuously slowly stably, thereby can prevent for a long time that mycete from breeding in indoor set at the atmosphere gas situation.

In the above-described configuration, in case the ratio of space segment with the indoor set internal capacity is set in 1: 500～5000 scopes, volumetric ratio optimization between the space segment that just can make the high concentration space segment of medicament steam delay and wish to make it to discharge, when obtaining fully to prevent the mycete effect, can also provide a kind of environment that does not have unplessantness displeasure for the air conditioner user.

In addition, relative by the humidity sensitive face that makes slow released parts of volatile medicine with the upstream side of heat exchanger, can feel rapidly and rise, thereby can improve the responsiveness of medicament slow release from the humidity of heat exchanger side.

In addition, the present invention also relates to a kind of slow released parts of volatile medicine, wherein make under liquid preparation curing or the thickening state, volatile quantity controlling diaphragm with the described medicament volatile quantity of control is done outer package, in the outer package of described volatile quantity controlling diaphragm, has the humidity sensing film that the transit dose of described medicament changes with humidity, between described volatile quantity controlling diaphragm and described humidity sensing film, be provided with and make evaporable described medicament steam be detained the space segment of usefulness, the volatilization of described medicament is remained on below certain vapor concentration in the described space segment of described volatile quantity controlling diaphragm and the intermembranous formation of described humidity sensitive, the medicament that is trapped in the described space segment is slowly discharged to the outside from described humidity sensing film according to the humidity environment variation of outside.

By above-mentioned formation, under the state that makes liquid preparation curing or thickeningization, the orientation of slow released parts of volatile medicine can be corresponding with any situation, and the volatile quantity of the medicament controlling diaphragm that can be provided with in outer package does concentration control, evaporable composition is full of is trapped in to have certain volumetrical space segment.If outside humidity is low, the medicament steam that is full of from then on space segment further discharges to the outside, then finally is controlled in substantially below the saturated vapor pressure CONCENTRATION STATE, thereby can suppresses from the quantity of slow released parts of volatile medicine to outside release.And in case outside humidity height, the medicament steam that volatilization is full of will see through and make the humidity sensing film that the secondary controlling diaphragm is used, and discharges to the outside.Thereby can provide a kind of slow released parts of volatile medicine that can discharge this function admirable of low concentration medicament steam from the high concentration space segment of volatile medicine steam according to damp condition.Specifically, can under 30 ℃ and 95% relative humidity, reach the purpose that discharges 100 milligrams of/day levels effectively.And medicament steam owing to adopt makes it to volatilize to the space segment that once had been full of and is detained, and then the secondary slow release diffusion way that discharges to the outside, so even the medicament liquid measure reduces variation gradually, be cured or the liquid level of thickeningization and controlling diaphragm between the space segment concentration controlled by vapor liquid equilibrium.

Therefore, owing to the volume that is formed space segment by controlling diaphragm and secondary controlling diaphragm changes the maximum space volume that produces greater than a controlling diaphragm inside because of the medicinal liquid liquid measure, thus can with slow released parts of volatile medicine institute release medicine vapor concentration through the time variable quantity be reduced to certain degree.And liquid preparation is being solidified or the thickening condition under, slow released parts of volatile medicine is exposed to high temperature following time, also can reduce the meltage of oxygen in medicament, the result can improve the durability for oxidative degradation.

In addition, when being set in 2: 1～10: 1 scope in the weight ratio of solid macromolecule storeroom liquid preparation and curing or thickeningization, make under the condition of weight ratio greater than curing or the required solid macromolecule material of thickeningization of liquid preparation, liquid preparation through the time weight change easily identification that also becomes, user can simply be judged the residual quantity of medicament.

In addition,, from macromolecular material, the foul smell that makes people's unplessantness displeasure can be do not produced, the usefulness of volatile medicine can be continued to keep for a long time as the solid macromolecule material that liquid preparation solidifies or thickeningization is required is used under the situation of cellulose ethylether.And the weight average molecular weight of cellulose ethylether is set under the condition more than 100,000, liquid preparation fully produced solidify or the effect of thickeningization.In addition, the cellulose ethylether is mixed the effect that can also obtain to prevent the medicament oxidation with liquid preparation, and can use no or little antioxidant.

Promptly use polyvinyl butyral resin to make the solid macromolecule material, from macromolecular material, also can not produce tedious foul smell, can continue to keep the usefulness of volatile medicine for a long time.And reach more than 100,000 when the weight average molecular weight of polyvinyl butyral resin, hydroxyl mole % is in below 25% in the molecule, and the butyral degree reaches under the condition 70% or more in the molecule, can make liquid preparation fully produce the effect of curing or thickeningization.In addition polyvinyl butyral resin is mixed the effect that can also obtain to prevent the medicament oxidation with liquid preparation, and can use no or little antioxidant.

And the present invention also relates to a kind of manufacture method of slow released parts of volatile medicine, comprising using methanol, ethanol, isopropyl alcohol or acetone etc. with after cellulose ethylether or the polyvinyl butyral resin swelling, after adding allyl isosulfocyanate, tea tree oil or Eucalyptus oil are made the admixture with viscosity, make methanol, ethanol, isopropyl alcohol or acetone volatilization, reduce mobile, make tablet state, do outer package with the volatile quantity controlling diaphragm then, outer again dress is with humidity sensing film.

By means of said method, with boiling point than the low organic solvent of medicament with the swelling of solid macromolecule material after, add medicament and can reach admixture earlier, and then can simply medicament be made tablet state by the evaporation organic solvent again, improve chemicals treatment performance thereafter.And can also the messenger drug agent spread by the volatile quantity controlling diaphragm equably substantially.

In addition, the invention still further relates to a kind of slow released parts of volatile medicine, comprising volatile medicine being set at internal tank, make at least a portion of described container have the humidity sensing film that described medicament transit dose changes with humidity, described humidity sensing film surface layer contains hygroscopy material or silica gel.

The present invention also relates to a kind of slow released parts of volatile medicine, comprising the volatile quantity controlling diaphragm inside that volatile medicine is arranged on the described medicament volatile quantity of control, the outer package of described volatile quantity controlling diaphragm has the humidity sensing film that the transit dose of described medicament changes with humidity, the surface layer of described humidity sensing film contains hygroscopy material or silica gel, between described volatile quantity controlling diaphragm and described humidity sensing film, be provided with and make evaporable described medicament steam be detained the space segment of usefulness, the volatilization of described medicament remains on below certain vapor concentration in the described space segment of described volatile quantity controlling diaphragm and the intermembranous formation of described humidity sensitive, and the medicament that is trapped in simultaneously in the described space segment slowly discharges to the outside from described humidity sensing film according to the humidity environment variation of outside.

Contain hygroscopy material or silica gel by the surface layer that makes humidity sensing film, for example can make under 25 ℃ and 60% relative humidity sensitivity to dampness than existing height, can provide moisture content effectively to the viscose rayon film that constitutes the humidity sensitive membrane matrix, its as a result the viscose rayon film become a kind of swelling structure, the medicament of slow released parts of volatile medicine inside is seen through from viscose rayon easily.Under high humility atmosphere, can keep certainly and in the past same release characteristics.And in manufacturing process, contain hygroscopy material or silica gel by the surface layer that makes humidity sensing film, particularly take care of under the situation about manufacturing a product winter in summer, humidity sensing film also keeps humidity easily, can pack humidity sensing film under the state that keeps dampness.Its result can prevent breaking in the humidity sensing film keeping.

The hygroscopy material uses calcium chloride, lithium chloride, calcium bromide, magnesium bromide, lithium bromide, calcium iodide, magnesium iodide or lithium iodide separately or uses under the condition of its mixture, can improve near the medicament release characteristics of 60% relative humidity, a kind of slow released parts of volatile medicine that has the linear release characteristics of medicament from low humidity to high humility atmosphere gas can be provided.

And make under the condition that contains 0.2～1 gram/square metre hygroscopy material on the surface of humidity sensing film, near energy under the hygroscopy content of material freely be controlled 60% relative humidity medicament release characteristics can provide bigger degree of freedom to the medicament release characteristics of slow released parts of volatile medicine.

Perhaps be set under the condition of 10～100 dusts in the average pore diameter with silica gel, humidity sensing film is pounced on the collection amount near the moisture content of humidity 60% relative humidity.Its result can make the medicament burst size also increase, and can provide a kind of and have the slow released parts of volatile medicine of the linear release characteristics of medicament to the high humility atmosphere gas scope at low humidity.

And make under the condition that contains 0.5～5 gram/square metre silica gel on the humidity sensing film surface, near energy under the silica gel content freely be controlled 60% relative humidity medicament release characteristics can provide bigger degree of freedom to the medicament release characteristics of slow released parts of volatile medicine.

In addition, at least have heat exchanger and using the indoor set of fan through regulating wind to the indoor temperature that is blown into from described heat exchanger, be arranged near the heat exchanger upstream side by slow released parts of volatile medicine with above-mentioned formation, can give slow released parts of volatile medicine in low humidity to the linear burst size characteristic of the medicament in the high humility atmosphere gas scope, can prevent the inner generation of indoor set in summer mycete.

In addition, the manufacture method of the humidity sensing film that the present invention relates to wherein has: first operation that forms the viscose rayon film on one of polyethylene film, polypropylene screen, polyurethane film, nylon membrane, polyethylene terephthalate film or its composite laminate film by non-woven fabrics; With with containing the aqueous solution that hygroscopy material or silica gel are formed, described hygroscopy material or silica gel are disperseed second operation of carrier band on described viscose rayon surface layer.

Pass through said method, promptly on resin molding, form the operation and the method that makes hygroscopy material or silica gel disperse the operation of carrier band to constitute respectively successively of viscose rayon film, can provide a kind of moisture sensitivity good, for the humidity sensing film that has the linear burst size characteristic of medicament from low humidity to high humility atmosphere gas.

Description of drawings

Fig. 1 is the front appearance figure of the slow released parts of volatile medicine of embodiment 1 and 5

Fig. 2 is the side view of the slow released parts of volatile medicine section structure of embodiment 1

Fig. 3 is the side view of the indoor machine of air conditioner section structure of embodiment 1,5,16

Fig. 4 is the front appearance figure of the slow released parts of volatile medicine of embodiment 2

Fig. 5 is the side view of the slow released parts of volatile medicine section structure of embodiment 2

Fig. 6 is the front appearance figure of the slow released parts of volatile medicine of embodiment 3

Fig. 7 is the side view of the slow released parts of volatile medicine section structure of embodiment 3

Fig. 8 is the front appearance figure of the slow released parts of volatile medicine of embodiment 4 and 12

Fig. 9 is the side view of the slow released parts of volatile medicine section structure of embodiment 4

Figure 10 is the side view of the slow released parts of volatile medicine section structure of embodiment 5

Figure 11 is the allyl isosulfocyanate release characteristics figure that embodiment 5 obtains slow released parts of volatile medicine

Figure 12 is the side view of the slow released parts of volatile medicine section structure of embodiment 12

Figure 13 is the top outside drawing of the slow released parts of volatile medicine of embodiment 13

Figure 14 is the section structure side view of the slow released parts of volatile medicine of embodiment 13 along A-A ' line

Figure 15 is the medicament burst size of slow released parts of volatile medicine of embodiment 11,13,14 and the graph of a relation between the moisture sensitivity

Figure 16 is the top outside drawing of the slow released parts of volatile medicine of embodiment 16

Figure 17 is the section structure side view of the slow released parts of volatile medicine of embodiment 16 along B-B ' line

Figure 18 is the section structure side view of the slow released parts of volatile medicine of embodiment 16 along C-C ' line

Figure 19 is the medicament burst size of slow released parts of volatile medicine of embodiment 16,17,18 and the graph of a relation between the moisture sensitivity.

The specific embodiment

(embodiment 1)

Fig. 1 is the front appearance figure of the slow released parts of volatile medicine of expression embodiment, and Fig. 2 is the section structure side view of slow released parts of volatile medicine.The 1st, absorb do medicament with allyl isosulfocyanate after the polyurethane continuous multi-hole body of swelling.Specifically make 35 * 71 * 2 polyurethane continuous multi-hole body, bulk density 0.35 grams per milliliter, 30 microns of average pore diameters, the porosity 70%) absorb approximately swelling to 50 * 100 * 2.8 behind the 15.5 gram allyl isosulfocyanates.The 2nd, this material of filling container of being made by water white polyethylene terephthalate (PET) is through what process the amorphism PET sheet material vacuum forming of 1 millimeter of thickness.The 3rd, the control allyl isosulfocyanate stack membrane that volatile quantity is used from the polyurethane continuous multi-hole body is made by the polyethylene of 30 microns polypropylene and 70 microns, makes controlling diaphragm usefulness one time.The outer peripheral portion of stack membrane fuses polyethylene one side on pet container 2 with heat sealing method.The 4th, at the polyethylene superimposed layer humidity sensing film of viscose rayon paper, make the secondary controlling diaphragm and use.Humidity sensing film 4 also is that outer peripheral portion is fused polyethylene one side on pet container 2 with heat sealing method.Humidity sensing film 4 uses on 30 microns polyethylene films and forms the material of viscose rayon film with artificial silk/paper pulp non-woven fabrics with 7 grams/square metre coating weight.The 5th, by the space segment that stack membrane 3 and humidity sensing film 4 form, this spatial volume is 30 milliliters.From the evaporable allyl isosulfocyanate steam of polyurethane continuous multi-hole body, its volatile quantity arrives the space segment 5 that is formed by stack membrane 3 and humidity sensing film 4 when being subjected to stack membrane 3 controls.For example the vapour pressure at 25 ℃ of following allyl isosulfocyanates is about 5 mm Hg, so the maximum the inner saturated vapor concentration of controlling diaphragm becomes about 6600ppm immediately, exist in the space segment 5 with it with corresponding to a certain degree Concentraton gradient, be full of the allyl isosulfocyanate steam simultaneously, if the burst size of secondary controlling diaphragm is few, till when then volatile quantity can increase to the vapour pressure characteristic corresponding with atmosphere gas temperature to a certain degree, finally make spatial portion 5 vapor concentration that almost reaches capacity.Under the low humidity situation, the allyl isosulfocyanate steam that discharges to the outside is owing to controlled by humidity sensing film 4 to a certain extent, so space segment 5 can maintain under the state near saturated vapour pressure concentration just.In case but humidity increases, the allyl isosulfocyanate steam just sees through humidity sensing film 4 easily and discharges to the outside.Humidity sensing film 4 is the lax structure of a kind of membrane tissue swelling because of humidity becomes, and the allyl isosulfocyanate molecule sees through humidity sensing film easily and discharges to the outside.In order to replenish this burst size, the allyl isosulfocyanate steam that volatilizes from the polyurethane continuous multi-hole body must be full of space segment 5 by stack membrane 3 again.At this moment, discharge the speed of allyl isosulfocyanate to the outside from humidity sensing film 4, compare with the allyl isosulfocyanate diffusion velocity that sees through space segment 5 from the evaporable allyl isosulfocyanate of polyurethane continuous multi-hole body, because the latter is faster, so the burst size of allyl isosulfocyanate can be sufficient.By the slow released parts of volatile medicine of this structure, make under 30 ℃ and the 95% relative humidity condition with 100 milligrams of/day levels from humidity sensing film continuously release medicine become possibility.And from the characteristic of slow released parts of volatile medicine release medicine, almost constant reach below the 10 weight % at initial stage up to the allyl isosulfocyanate residual volume before.

Just use below that the indoor set to air conditioner describes under the slow released parts of volatile medicine situation of present embodiment.

Fig. 3 is the cross-section structure of expression present embodiment indoor machine of air conditioner.Suck room airs by sucking grille 6,7, inhaled air after heat exchanger 8,9 coolings, dehumidifying, on one side by convection fan 10 suction drafts, on one side from final air outlet 11 to the indoor cold wind that provides.Air outlet 11 is provided with the blade 12 of deflection up and down, and control is to the indoor direction that blows out.This moment through the dew of heat exchanger 8,9 dehumidifying attached to the heat exchanger aluminum blades on, flow in the drain pan 13,14.Drain pan 13 is made one with Shelf 15, and drain pan 14 forms one with air outlet grille 16.Be trapped in dew on the drain pan 13 and flow to drain pan 14 1 sides by frame 15 and hold, finally drain into the outside via the discharge outlet (not shown).In order to make the heat exchange performance high efficiency of heat exchanger 8,9 aluminum blades, its structure is provided with vertical joint-cutting.Therefore agglomerative dew forms moisture film in the joint-cutting part because of surface tension, owing to be difficult to drip to drain pan 13,14 immediately on the structure, thereby make the aluminum blades rate of drying slow down.For example under the ambiance of 25 ℃ and 90% relative humidity, the heat exchanger aluminum blades is dry to need tens of hours, is difficult to dry.Indoor set space, the particularly inner space in the air-supply loop that is made of heat exchanger 8,9 will be exposed in the atmosphere gas greater than 95% relative humidity this moment, form the environmental condition that mycete is very easy to breeding.The 17th, slow released parts of volatile medicine is set at the upstream side near heat exchanger 9 bottoms, makes humidity sensing film 4 sides of slow released parts of volatile medicine 17 relative with heat exchanger on the structure.So, after refrigeration, dehumidifying running stop, the blade 12 of deflection becomes closed condition up and down, being in air under the high humility state simultaneously, in a single day to be full of indoor set all and arrive at humidity sensing film 4 places, allyl isosulfocyanate will be from slow released parts of volatile medicine 17 inner heat exchanger 9 sides diffusions, when between aluminum blades, passing through, because of deflecting blade 12 up and down be in closed condition slowly to the diffusion that grades by heat exchanger 8,9 spatial portions that constituted, accumulate and be full of.The result just may be detained about 3～5ppm by the bottom, space that heat exchanger 8,9 is constituted, even also can be detained the allyl isosulfocyanate steam more than the 1ppm in low concentration space, top in indoor set inside.Be trapped in the high concentration allyl isosulfocyanate steam in slow released parts of volatile medicine 17 space segments 5, through the spatial diffusion of humidity sensing film 4 to 500～5000 times.The threshold value of allyl isosulfocyanate is about 10ppm, is under the level of imperceptible fragrance so steam is detained concentration.Therefore can obtain sufficient anti-mold effect to the general mycete that is called as Cladosporium, Alternaria, Aspergillus, Pencillium and relative humidity izopus that is present in the interior space.In order to obtain the anti-mold effect of indoor set, wish that the allyl isosulfocyanate steam that is detained in the indoor set is in more than the 0.5ppm, wish in the practicality to be in below the 10ppm of human threshold value.Therefore, it is believed that, preferably be in 1: 500～about 5000 times in the space segment of the inner medicament steam delay that constitutes of slow released parts of volatile medicine and the volumetric ratio between the indoor set inner space.

The liquid measure of medicament is because container uses transparent amorphism PET resin, so user can be visually observed the shape of polyurethane continuous multi-hole body.The decrement state is owing to the simple affirmation of variable quantity total energy of polyurethane continuous multi-hole body size, so can judge easily the replacing time.

Though what adopt among the embodiment is in one side the humidity sensing film of slow released parts of volatile medicine to be set, and makes its humidity sensing film one side structure relative with the suction upstream face of heat exchanger, the present invention is not limited to this structure.But consider under the situation of medicament with light time replacing slow released parts of volatile medicine that the heat exchanger upstream side outside suction grille 7 is arranged on is convenient to user and is safeguarded.And, preferably adopt this in order to improve the medicament service efficiency and to make it rapid release

Example structure.

(embodiment 2)

Fig. 4 is the front appearance figure of the slow released parts of volatile medicine of expression present embodiment, and Fig. 5 is the section structure side view of slow released parts of volatile medicine.The 18th, absorbed the polyurethane continuous multi-hole body of swelling behind the allyl isosulfocyanate.Specifically make 35 * 71 * 2 polyurethane continuous multi-hole body (bulk density 0.35 grams per milliliter, 30 microns of average pore diameters, the porosity 70%) absorb approximately swelling to 50 * 100 * 2.8 behind the 15.5 gram allyl isosulfocyanates.The 19th, make the heat sealed package body of polyurethane continuous multi-hole body 18 outer package with stack membrane, for 30 microns polypropylene and 70 microns heat sealed package product that poly stack membrane is made the heat-sealing of polyethylene one side, make a controlling diaphragm and use.The 20th, this material of filling container of making by water white polyethylene terephthalate (PET), injection molded being processed into.The 21st, stack membrane heat sealed package body 19 is fixedly remained on PP latch on the pet container 20, make the structure that embeds on the pet container.The 22nd, the polyethylene superimposed layer humidity sensing film of viscose rayon paper, make secondary controlling diaphragm usefulness, identical with embodiment 1 structure.The 23rd, make that evaporable allyl isosulfocyanate is full of from heat sealed package, be detained and use space segment, its space solvent is 30 milliliters.From polyurethane continuous multi-hole body 18 evaporable allyl isosulfocyanates, on one side its volatile quantity is subjected to stack membrane 19 controls, Yi Bian arrive by stack membrane 19 and humidity sensing film 22 formed space segments.Here with the volatilization of atmosphere temperature is corresponding to a certain degree vapour pressure characteristic, space segment 23 is reached capacity under the vapour pressure concentration substantially.Under the low humidity situation, the steam that allyl isosulfocyanate discharges to the outside is owing to be subjected to humidity sensing film 22 controls in a way, so space segment 23 maintains under the state near saturated vapour pressure concentration just.In case but humidity increases, the allyl isosulfocyanate steam just sees through humidity sensing film 22 easily and discharges to the outside.Humidity sensing film 22 will become a kind of membrane tissue and change the lax structure of swelling because of humidity, and the allyl isosulfocyanate molecule sees through humidity sensing film easily and discharges to the outside.In order to replenish this burst size, must further be full of space segment 23 by stack membrane heat sealed package body 19 from polyurethane continuous multi-hole body 18 evaporable allyl isosulfocyanates.Discharge the speed of allyl isosulfocyanate this moment to the outside from humidity sensing film 22, compare with the diffusion velocity that sees through space segment 23 back allyl isosulfocyanates from polyurethane continuous multi-hole body 18 evaporable allyl isosulfocyanates, so because the burst size of the faster allyl isosulfocyanate of the latter can be sufficient.By the slow released parts of volatile medicine of this structure, under 30 ℃ and 95% relative humidity condition, with 100 milligrams of/day levels from humidity sensing film continuously release medicine become possibility.

Though be to use the PP latch that stack membrane heat sealed package body is fixed on the pet container in the present embodiment, also can the bottom and the heat sealed package body of pet container be fixed with two-sided tape or hot melt.

(embodiment 3)

Fig. 6 is the front appearance figure of the slow released parts of volatile medicine of expression present embodiment, and Fig. 7 is the section structure side view of slow released parts of volatile medicine.The 24th, absorbed the polyurethane continuous multi-hole body of swelling behind the allyl isosulfocyanate.Specifically make 35 * 71 * 2 polyurethane continuous multi-hole body (bulk density 0.35 grams per milliliter, 30 microns of average pore diameters, the porosity 70%) absorb approximately swelling to 50 * 100 * 2.8 behind the 15.5 gram allyl isosulfocyanates.The 25th, do 24 outer package of polyurethane continuous multi-hole body with four limit deep drawing package bodies of stack membrane, the package of the four limit deep drawings of the heat-sealing of polyethylene one side being made for 30 microns polypropylene and 70 microns poly stack membranes is made controlling diaphragm usefulness one time.The 26th, this material of filling container of being made by water white amorphism PET is processed into the PET film of 1 millimeter of thickness through vacuum forming.The 27th, with the humidity sensing film of making at polyethylene superimposed layer viscose rayon converted paper,, identical with embodiment 1 as the secondary controlling diaphragm.The 28th, make that evaporable allyl isosulfocyanate is full of, is detained and uses space segment in the four limit deep drawing package bodies, this space solvent is 30 milliliters.With the sandwich structure form, with the outer peripheral portion of the package body 25 of the outer peripheral portion of humidity sensing film 27 and four limit deep drawings heat-seal bond together on pet container 26.The 29th, two-sided tape is bonded together the above ground portion of the package body of four limit deep drawings and the bottom surface portions of pet container 26 safely.

Though be to use two-sided tape that the package body of four limit deep drawings of stack membrane is fixed on the pet container in the present embodiment, also can the bottom surface portions of the package body of the bottom surface portions of pet container and four limit deep drawings be fixed with hot melt.

(embodiment 4)

Fig. 8 is the front appearance figure of the slow released parts of volatile medicine of expression present embodiment, and Fig. 9 is the section structure side view of slow released parts of volatile medicine.The formation of slow released parts of volatile medicine main body is owing to identical substantially with embodiment 1, so only be illustrated with regard to different piece.The 30th, the non-permeability film that is made of polyethylene/nylon/aluminium foil/polyethylene structure is fixed on the pet container 2 by the electric hot plate hot melt humidity sensing film is covered, and prevents the allyl isosulfocyanate vapour leakage.The part of non-permeability film 30 has part outstanding outside pet container 2 has a mind, and its structure is that hand-held this ledge is peeled off non-permeability film 30 easily.During use non-permeability film 30 peeled off from slow released parts of volatile medicine and can realize following function.From the allyl isosulfocyanate that the polyurethane continuous multi-hole body volatilizes, its volatile quantity limit is controlled by stack membrane, arrive by stack membrane and humidity sensitive film formed space segment on one side.Here with the volatilization of atmosphere temperature is corresponding to a certain degree vapour pressure characteristic, space segment is reached capacity under the vapour pressure concentration substantially.Under the low humidity situation, the steam that allyl isosulfocyanate discharges to the outside is owing to controlled by humidity sensing film in a way, so space segment maintains under the state near saturated vapour pressure concentration just.In case but humidity increases, the allyl isosulfocyanate steam will see through humidity sensing film 22 and discharge to the outside.In order to replenish this burst size, allyl isosulfocyanate further volatilizees from the polyurethane continuous multi-hole body, replenishes to space segment by stack membrane.

Though be to use the container of water white amorphism PET resin manufacture filling medicament in the present embodiment, the present invention is not limited to this.Also can select the other materials that the medicament of filling is had resistance to chemical reagents for use.In order simply to confirm the liquid measure of medicament, also can use, for example acrylic resin, polycarbonate resin, poly-other resins that (ethylene naphthalate) resin, polyvinyl resin, methylpentene resin etc. had the transparency with visual means.But because amorphism PET resin when being configured as sheet material with vacuum processing or pressure processing, can provide slow released parts of volatile medicine with container and obtain with cheapness.

Though be to use the polyurethane continuous multi-hole body as liquid absorbent material in the present embodiment, that can use in the present invention is not limited to this.Keep the adequately expanded material of volume behind the liquid so long as can absorb, just do not have special problem.Even preferably those long-time absorptions keep also keeping the original shape of continuous multi-hole body behind the volatile medicine, and reduce the material that slowly shrinks along with the pharmaceutical quantities that keeps.And because the present invention will slowly discharge the material of being made up of plants essential oil with low concentration, so want the word material that preferably lipophile is good can improve the liquid conservation rate.Specifically, for continuous multi-hole body, when the average pore diameter as physical property reaches 10～100 microns, the porosity reaches 50～90% words, the liquid conservation rate of medicament can obtain to reach more than 100% in volume ratio, and volume swelling rate reaches the effect more than 200%.As trend, have volume swelling rate is strengthened.And the big more volume swelling rate that can make more certainly of the porosity increases, but mechanical strength is too small when the porosity is excessive, and shape is collapsed easily.Except polyurethane, can also use polypropylene, polyethylene, polyvinyl alcohol etc. as continuous multi-hole body, but the extent when liquid keeps is but different because of the kind of resin.The material that extends is the polyurethane continuous multi-hole body especially easily.These liquid absorbent material initial stage volumes produce fully and expand, along with maintenance liquid measure minimizing and slowly shrink, user can be according to this character from outside visualization slow released parts of volatile medicine, holds the residual liquid amount of medicament, thereby can confirm should be with the period of its replacing.In addition, even in fact long-time use also can be kept original shape of continuous multi-hole body.

In the present embodiment, though used polypropylene and poly composite laminate film as medicament volatile quantity controlling diaphragm, that can use among the present invention is not limited to this.Can use polyethylene film, polypropylene screen, polyurethane film, nylon membrane or polyethylene terephthalate film or use with its laminated construction film that is composited in addition separately.

In the present embodiment, though special-purpose allyl isosulfocyanate, that can use in the present invention is not limited to this.Can also use tea tree oil or Eucalyptus oil.And so long as can obtain antibiotic and medicament anti-mold effect under the low concentration volatile quantity, the medicament that just can be used as slow released parts of volatile medicine of the present invention uses.

In the present embodiment, though used the film that is made of polyethylene/nylon/aluminium foil/polyethylene structure as non-permeability film, that can use in the present invention is not limited to this.Generally speaking, can use with the aluminium foil more than 5 microns and make the laminated construction film of internal layer as non-permeability film.And in the present invention, use and can have with resin under the situation of good electric hot plate fusion character and ultrasonic wave fusion film with the slow released parts of volatile medicine container, can be from slow released parts of volatile medicine with only non-permeability film being peeled off simply on the container.

Though present embodiment only just is used for illustrating that the purposes of slow released parts of volatile medicine of the present invention is not limited to this under the situation of general separate type air conditioner indoor set.Can be widely used in and to prevent to make among mycete, the vegetative various fields because of seasonal move or this place atmosphere gas humidity environment change.For example can be used for bathroom, dressing cubicle, wood shoe cabinet, food cabinet, storeroom, underground storehouse etc.And can also be used for or building idle call humidification path and the ventilation path medium.

(embodiment 5)

Fig. 1 is the front appearance figure of the slow released parts of volatile medicine of expression present embodiment, and Figure 10 is the section structure side view of slow released parts of volatile medicine.The 2nd, with the container that polyethylene terephthalate (PET) is made, utilize the amorphism PET sheet material of 1 millimeter of vacuum forming method processing thickness.Inside dimension is 50 * 140 * 10 millimeters.The 31st, the allyl isosulfocyanate of using as volatile medicine is solidified the tablet that forms on the cellulose ethylether.Specifically, (Nisshin Kasei Co. Ltd makes with 7.5 gram cellulose ethylether powder, commodity are called Etta Xi Er (ェ ト セ Le) STD-100, weight average molecular weight 180,000) place shaping dies after, add 15 gram ethanol, place and add 15 gram allyl isosulfocyanates after 1 hour again, room temperature state is placed down and was made ethanol evaporation in 48 hours, and allyl isosulfocyanate is made tablet with the cellulose ethylether.The 19th, make the heat sealed package body of allyl isosulfocyanate volatilization controlling diaphragm with stack membrane, using as controlling diaphragm, is that 40 * 120 * 4 millimeters tablet will obtaining is packaged in the stack membrane of being made by 30 microns polypropylene and 70 microns polyethylene and seals the heat sealed package body that forms with polyethylene one side.The 4th, the humidity sensing film in that polyethylene superimposed layer viscose rayon converted paper is made uses as the secondary controlling diaphragm.Humidity sensing film 4 also is to make polyethylene one face down bonding connect fusion on pet container 2 with heat sealing method outer peripheral portion.Humidity sensing film 4 uses on 30 microns polyethylene films and forms the material of viscose rayon film by artificial silk/paper pulp non-woven fabrics with 7 grams/square metre coating weight.The 5th, by the space segment that stack membrane 19 and humidity sensing film 4 form, this spatial volume is 40 milliliters.The heat sealed package body 19 of stack membrane is by carrying out fixed-site with polyethylene hot melt (not shown) in the mode of the inner face bottom of pet container 2.

From the evaporable allyl isosulfocyanate steam of tablet, its volatile quantity arrives stack membrane 19 and humidity sensing film 4 formed space segments 5 when being subjected to stack membrane 19 controls.For example because the vapour pressure of 25 ℃ of following allyl isosulfocyanates is about 5 mm Hg, so the saturated vapor concentration of a controlling diaphragm inside becomes about 6600ppm immediately, space segment 5 has with it with corresponding to a certain degree Concentraton gradient, be full of the allyl isosulfocyanate steam simultaneously, if the burst size of secondary controlling diaphragm is few, till when then volatile quantity will increase to the vapour pressure characteristic corresponding with atmosphere gas temperature to a certain degree, the final space segment 5 vapour pressure concentration that almost can reach capacity.Under the low humidity situation, the steam that allyl isosulfocyanate discharges to the outside is subjected to humidity sensing film 4 controls to a certain extent, so space segment 5 maintains just near under the saturated vapour pressure CONCENTRATION STATE.In case but humidity increases, the allyl isosulfocyanate steam just sees through humidity sensing film 4 easily and discharges to the outside.Humidity sensing film 4 is the lax structure of a kind of membrane tissue swelling because of humidity becomes, and the allyl isosulfocyanate molecule is seen through easily discharge to the outside.In order to replenish this burst size, the allyl isosulfocyanate steam from tablet 31 volatilizes must further be full of space segment 5 by stack membrane 19.At this moment, discharge the speed of allyl isosulfocyanate to the outside from humidity sensing film 4, compare with the diffusion velocity that sees through the allyl isosulfocyanate of space segment 5 from tablet 31 evaporable allyl isosulfocyanates, so because the burst size of the faster allyl isosulfocyanate of the latter can be sufficient.Utilization has the slow released parts of volatile medicine of this structure, under 30 ℃ and 95% relative humidity condition, with 100 milligrams of/day levels from humidity sensing film continuously release medicine become possibility.And from the characteristic that the slow released parts of volatile medicine medicament discharges, almost constant reach below the 10 weight % at initial stage up to the allyl isosulfocyanate residual volume before.Figure 11 represents the release characteristics of the allyl isosulfocyanate of the slow released parts of volatile medicine that embodiment 5 obtains.

Below use the situation of the slow released parts of volatile medicine of present embodiment to describe with regard to the indoor set of air conditioner

Fig. 3 is the cross-section structure of expression present embodiment indoor machine of air conditioner.Suck room airs by sucking grille 6,7, inhaled air after heat exchanger 8,9 coolings, dehumidifying, on one side by convection fan 10 suction drafts, on one side from final air outlet 11 to the indoor cold wind that provides.Air outlet 11 is provided with the blade 12 of deflection up and down, and control is to the indoor direction that blows out.This moment through the dew of heat exchanger 8,9 dehumidifying attached to the heat exchanger aluminum blades on, flow in the drain pan 13,14.Drain pan 13 is made one with Shelf 15, and drain pan 14 forms one with air outlet grille 16.Be trapped in dew on the drain pan 13 and flow to drain pan 14 1 sides by frame 15 and hold, finally drain into the outside via the discharge outlet (not shown).In order to make the heat exchange performance high efficiency of heat exchanger 8,9 aluminum blades, be provided with vertical kerf structure.Therefore agglomerative dew forms moisture film in the joint-cutting part because of surface tension, owing to be difficult to drip to drain pan 13,14 immediately on the structure, thereby make the aluminum blades rate of drying slow down.For example under the ambiance of 25 ℃ and 90% relative humidity, the heat exchanger aluminum blades is dry to need tens of hours, is difficult to dry.The indoor set space particularly will be exposed in the atmosphere gas of 95% above relative humidity by the inside, air-supply loop that heat exchanger 8,9 constitutes this moment, form the environmental condition that a kind of mycete is very easy to breeding.The 17th, slow released parts of volatile medicine is set at the upstream side near heat exchanger 9 bottoms, makes humidity sensing film 4 sides of slow released parts of volatile medicine 17 relative with heat exchanger on the structure.So, after refrigeration, dehumidifying running stop, the blade 12 of deflection becomes closed condition up and down, being in air under the high humility state simultaneously, to be full of indoor set all, in case arrive humidity sensing film 4 places, allyl isosulfocyanate will be from slow released parts of volatile medicine 17 inner heat exchanger 9 sides diffusions, when between aluminum blades, passing through, because up and down deflecting blade 12 is in closed condition, so, accumulate simultaneously and be full of slowly to the diffusion that grades by heat exchanger 8,9 spatial portions that constituted.The result just may be detained about 3～5ppm by heat exchanger 8,9 space segments that constituted in indoor set inside, even also can be detained the allyl isosulfocyanate steam more than the 1ppm in above-mentioned low concentration space.Be trapped in the high concentration allyl isosulfocyanate steam of slow released parts of volatile medicine 17 space segments 5, through the spatial diffusion of humidity sensing film 4 to 500～5000 times.The threshold value of allyl isosulfocyanate is under the level of imperceptible fragrance so steam is detained concentration owing to be about 10ppm.Therefore, for the general mycete that is called Cladosporium, Alternaria, Aspergillus, Pencillium and relative humidity izopus that is present in the interior space, can obtain sufficient anti-mold effect.In order to obtain the anti-mold effect of indoor set, wish that the allyl isosulfocyanate steam that is detained in the indoor set is in more than the 0.5ppm, wish in the practicality to be in below the 10ppm of human threshold value.Therefore, it is believed that, preferably be in 1: 500～about 5000 times in the space segment 5 of the inner medicament steam delay that constitutes of slow released parts of volatile medicine and the volumetric ratio between the indoor set inner space.

In the present embodiment because container uses transparent amorphism PET resin, so user can be visually observed the shape of tablet.By of the variable quantity total energy simple affirmation of decrement state, so can judge easily the replacing time by the tablet size.

Though the structure among the embodiment is in one side the humidity sensing film of slow released parts of volatile medicine to be set, and makes its humidity sensing film one side relative with the suction upstream face of heat exchanger, the present invention is not limited to this structure.But consider under the situation of medicament with light time replacing slow released parts of volatile medicine, be convenient to user under the situation of the heat exchanger upstream side outside suction grille 7 is arranged on and safeguard.And, preferably adopt the present embodiment structure in order to improve the medicament service efficiency and to make it rapid release.

(embodiment 6)

In the present embodiment, utilize allyl isosulfocyanate and the blended method of cellulose ethylether to be made it to be under the thickening state filling 15 gram mixture in stack membrane heat sealed package body similarly to Example 5 by 4: 1 weight ratios.Use stack membrane heat sealed package body as a controlling diaphragm,, obtain 40 * 125 * about 4 millimeters package 30 microns polypropylene and 70 microns heat sealed package bodies that poly stack membrane is made along the polyethylene side heat-sealing.As slow released parts of volatile medicine, the formation of holding the pet container of heat sealed package product and humidity sensing film is identical substantially with embodiment 5, and the heat sealed package body is by carrying out fixed-site with the polyethylene heat fused at the inner face lower curtate of pet container.The space segment size that is arranged between controlling diaphragm and the secondary controlling diaphragm is designed to 40 milliliters equally.

(embodiment 7)

In the present embodiment, by by 8: 1 weight ratios allyl isosulfocyanate and the blended method of cellulose ethylether being made it to be under the thickening state filling 15 gram mixture in stack membrane heat sealed package body similarly to Example 5.Use stack membrane heat sealed package body as a controlling diaphragm,, obtain 40 * 125 * about 4 millimeters package 30 microns polypropylene and 70 microns heat sealed package product that poly stack membrane is made along the polyethylene side heat-sealing.As slow released parts of volatile medicine, the formation of holding the pet container of heat sealed package body and humidity sensing film is identical substantially with embodiment 5, and the heat sealed package body is by carrying out fixed-site with the polyethylene heat fused at the inner face lower curtate of pet container.The space segment size that is arranged between controlling diaphragm and the secondary controlling diaphragm is designed to 40 milliliters equally.

Among the embodiment 5, because allyl isosulfocyanate is made into to be filled in behind the tablet in controlling diaphragm, so when causing liquid measure to reduce because of the allyl isosulfocyanate volatilization, board produces uniform shrinkage substantially, in contrast to this, in embodiment 6 and 7 because thickeningization only, so shown change shape is different with because of direction is set causes liquid measure to reduce of slow released parts of volatile medicine the time.But constantly fixed because of vapor liquid equilibrium at the inner medicament vapor concentration of controlling diaphragm, even slowly increase because of the pharmacy solution quantitative changeization causes a controlling diaphragm inner space volume, be arranged on the internal volume of the space segment 5 between controlling diaphragm and secondary controlling diaphragm, if bigger than the inner spatial volume that can hold of controlling diaphragm, then can with space segment 5 through the time to change caused concentration change inhibition little.

The cellulose ethylether is a kind ofly to make raw material with refined pulp, makes it in caustic soda after the alkali celluloseization and the ethyl chloride reaction, and the hydroxyl in the glucose is replaced to the material of ethyoxyl, and chemical equation is shown in (changing 1).

Change 1

Polyvinyl butyral resin

Outward appearance is a white powder, has almost the characteristic near odorless.The cellulose ethylether is to action effect of the present invention, even medicament solidifies or the effect of thickening depends on weight average molecular weight, specifically preferably more than 100,000.In addition, weight ratio is in 2: 1 and can solidifies under the condition between allyl isosulfocyanate and cellulose ethylether, along with weight ratio increases slowly lowering viscousity, we can say less than 10: 1 o'clock can not to produce the sort of thickening power to allyl isosulfocyanate stock solution.Thickening of the present invention is meant that viscosity reaches more than the 5000cp.In case and weight ratio is reduced to less than 2: 1,, increase the difficulty that user judges that liquid measure changes even the intensity of variation of figure of tablet also can reduce when the liquid measure of allyl isosulfocyanate changes.Therefore, we can say that weight ratio between allyl isosulfocyanate and cellulose ethylether preferably is in 2: 1～10: 1 scopes.

(embodiment 8)

In the present embodiment, use polyvinyl butyral resin that allyl isosulfocyanate is made tablet.Specifically, (Sekisui Chemical Co., Ltd makes to add 7.5 gram polyvinyl butyral resins in forming containers, Ai Sileke (ェ ス レ Star Network) B BH-S, weight average molecular weight 140,000,22 moles of % of hydroxyl, 73 moles of % of butyral degree) back interpolation 15 gram ethanol, place adding 15 gram allyl isosulfocyanates after 30 minutes, place under the room temperature and made ethanol evaporation in 48 hours, make the isopropyl isothiocyanate tableted with polyvinyl butyral resin.40 * 120 * 4 millimeters tablets that obtain are filled in similarly to Example 5 the stack membrane heat sealed package body.The heat sealed package body of stack membrane is made heat sealed package body with 30 microns polypropylene and 70 microns poly stack membranes along the polyethylene side heat-sealing as a controlling diaphragm.Hold the heat sealed package body used as slow released parts of volatile medicine and the formation of humidity sensing film, identical substantially with embodiment 5, by in the method for the inner face lower curtate of pet container the heat sealed package body position being fixed the polyethylene heat fused.The space segment size that is arranged between controlling diaphragm and the secondary controlling diaphragm is designed to 40 milliliters too.

(embodiment 9)

In the present embodiment, with 4: 1 weight ratios allyl isosulfocyanate is mixed to make it thickening with polyvinyl butyral resin, in this state 15 grams are filled in the stack membrane heat sealed package body similarly to Example 5., as a controlling diaphragm 30 microns polypropylene and 70 microns poly stack membranes along the polyethylene side heat sealed packageization, are made and are of a size of 40 * 125 * about 4 millimeters heat sealed package bodies with the heat sealed package body of stack membrane.Hold the heat sealed package body used as slow released parts of volatile medicine and the formation of humidity sensing film, identical substantially with embodiment 5, sharp by in the method for the inner face lower curtate of pet container the heat sealed package body position being fixed the polyethylene heat fused.The space segment size that is arranged between controlling diaphragm and the secondary controlling diaphragm is designed to 40 milliliters too.

(embodiment 10)

In the present embodiment, with 8: 1 weight ratios allyl isosulfocyanate is mixed to make it thickening with polyvinyl butyral resin, in this state 15 grams are filled in the stack membrane heat sealed package body similarly to Example 5., as a controlling diaphragm 30 microns polypropylene and 70 microns poly stack membranes along the polyethylene side heat sealed packageization, are made and are of a size of 40 * 125 * about 4 millimeters heat sealed package bodies with stack membrane heat sealed package body.The formation of holding the heat sealed package body used as slow released parts of volatile medicine and humidity sensing film is identical substantially with embodiment 5, at pet container inner face lower curtate, with the method the heat sealed package body position is fixed the polyethylene heat fused.The space segment size that is arranged between controlling diaphragm and the secondary controlling diaphragm is designed to 40 milliliters too.

(embodiment 11)

Allyl isosulfocyanate is absorbed and swelling on the polyurethane continuous multi-hole body.Specifically, make 35 * 71 * 2 polyurethane continuous multi-hole body (bulk density 0.35 grams per milliliter, 30 microns of average pore diameters, the porosity 70%) absorb approximately swelling to 50 * 100 * 2.8 behind the 15.5 gram allyl isosulfocyanates.Adopt mode similarly to Example 5 to make polyurethane continuous multi-hole body heat sealed packageization.Make a controlling diaphragm with it, with hot melt with the inner face bottom of its fixed-site at the container of making by water white amorphism PET.The reuse heat sealing method with the polyethylene superimposed layer humidity sensitive film coalescence of viscose rayon paper be bonded on the pet container.Evaporable allyl isosulfocyanate is full of to be detained and is designed to 40 milliliters with spatial internal volume from the heat sealed package body.

Polyvinyl butyral resin is the product that makes butyraldehyde and polyvinyl alcohol reaction, and reaction equation is shown in (changing 2)

Change 2

The cellulose ethylether

Butyralization fully in this butyral reaction is up to 81.6 moles of % in the past according to document is described.But if because of mole % height of butyralization residual hydroxyl fully, then can make and allyl isosulfocyanate between compatibility deterioration, can not obtain abundant effect.Therefore, the polyvinyl butyral resin that can use in the present invention preferably should be that weight average molecular weight is in more than 100,000, and to be in 25 moles of butyral degree mole % below the % and in the molecule be more than 70% to hydroxyl in the molecule.More preferably hydroxyl mole % is 20～25, and butyral degree mole % is 70%～80% in the molecule.In addition, weight ratio is in 2: 1 and can solidifies under the condition between allyl isosulfocyanate and cellulose ethylether, along with weight ratio increases slowly lowering viscousity, we can say less than 10: 1 o'clock can not to produce the sort of thickening power to allyl isosulfocyanate stock solution.Thickening of the present invention is meant that viscosity reaches more than the 5000cp.In case and weight ratio is reduced to less than 2: 1, the intensity of variation of figure of tablet also can reduce when the liquid measure of allyl isosulfocyanate changes, and increases the difficulty that user judges that liquid measure changes.Therefore, we can say that weight ratio between allyl isosulfocyanate and cellulose ethylether preferably is in 2: 1～10: 1 scopes.

The slow released parts of volatile medicine that obtains at embodiment 5～10 and embodiment 11, the effect that when placing under the open state in 45 ℃ of atmosphere gas allyl isosulfocyanate is discharged is as follows: among the embodiment 11 through 600 hours after allyl isosulfocyanate oxidized, from the light yellow buff that slowly becomes, again through overstrike after 1000 hours.Even but in embodiment 5,6,8 the medicament residual volume almost nil before allyl isosulfocyanate all not oxidized, not oxidized before 1600 hours among the embodiment 7, not oxidized before 1800 hours among the embodiment 9, not oxidized before 1200 hours among the embodiment 10.So, solidify or thickeningization by make allyl isosulfocyanate with cellulose ethylether or polyvinyl butyral resin, can reduce the meltage of oxygen in allyl isosulfocyanate, the result can obtain the effect of inhibited oxidation deterioration.And be somebody's turn to do the effect of preventing oxidation, more remarkable when using the cellulose ethylether.

As a reference, if in allyl isosulfocyanate, add antioxidant about 2 weight %, even be also not oxidized before zero until the medicament residual volume under the situation of embodiment 11 then.Therefore, effect of the present invention is, solidifies or thickeningization by make allyl isosulfocyanate with cellulose ethylether or polyvinyl butyral resin, makes to use no or little antioxidant and become possibility.

(embodiment 12)

Fig. 8 is the front appearance figure of the slow released parts of volatile medicine of expression present embodiment, and Figure 12 is the section structure side view of slow released parts of volatile medicine.The main body of slow released parts of volatile medicine constitute since with identical omission of embodiment 1 cardinal principle, only be illustrated with regard to different piece.The 30th, the non-permeability film by polyethylene/nylon/aluminium foil/polyethylene structure constitutes is fixed on covering humidity sensing film 4 on the pet container 2 by the electric hot plate hot melt, prevents the allyl isosulfocyanate vapour leakage.The part of non-permeability film 30 has part outstanding outside pet container 2 has a mind, and this structure will make hand-held this ledge easily non-permeability film 30 be peeled off.During use non-permeability film 30 is peeled off from slow released parts of volatile medicine, can be obtained action effect similarly to Example 5.

Though use water white amorphism PET resin manufacture filling medicament container in the present embodiment, can be not limited to this what the present invention used.Also can select the other materials that the filling medicament is had resistance to chemical reagents for use.In order simply to confirm the liquid measure of medicament, can use for example acrylic resin, polycarbonate resin, poly-other resins that (ethylene naphthalate) resin, polyvinyl resin, methylpentene resin etc. had the transparency with visual means.But because amorphism PET resin when sheet material is shaped with vacuum processing or pressure processing, can provide slow released parts of volatile medicine with container and obtain with cheapness.

In embodiment 5 and 8, with ethanol with cellulose ethylether or polyvinyl butyral resin swelling after, add allyl isosulfocyanate and make admixture, and then it is mobile that the ethanol volatilization is reduced, and finally can make it tableted.Be not limited to ethanol as the organic solvent that can use in the present invention, can use methanol, isopropyl alcohol, acetone in addition.

Though use polypropylene and poly composite laminate film as medicament volatile quantity controlling diaphragm among the embodiment, the organic solvent that can use in the present invention is not limited to this.Can use polyethylene sheets, crystalline p p sheet, polyurethane sheet, nylon membrane or polyethylene terephthalate film or use with its laminated construction film that is composited in addition separately.

In the present embodiment, though special-purpose allyl isosulfocyanate, that can use in the present invention is not limited to this.Can also use tea tree oil or Eucalyptus oil.And so long as the low concentration volatile quantity can obtain antibiotic down and medicament anti-mold effect, the medicament that just can be used as slow released parts of volatile medicine of the present invention uses.

In the present embodiment, though used the film that is made of polyethylene/nylon/aluminium foil/polyethylene structure as non-permeability film, that can use in the present invention is not limited to this.Generally speaking, can use with aluminium foil more than 5 microns and make the laminated construction film of internal layer as non-permeability film.And use in the present invention and can have with resin with the container of slow released parts of volatile medicine under the situation of good electric hot plate fusion character and ultrasonic wave fusion film, can be from slow released parts of volatile medicine with only non-permeability film being peeled off simply on the container.

Though only just be used in the present embodiment illustrating that the purposes of slow released parts of volatile medicine of the present invention is not limited to this under the situation of general separate type air conditioner indoor set.Can be widely used in and to prevent to make among mycete, the vegetative various fields because of seasonal move or this place atmosphere gas humidity environment change.For example can be used for bathroom, dressing cubicle, geta cabinet, food cabinet, storeroom, underground storehouse etc.And can also be used for or building idle call humidification path and the ventilation path medium.

(embodiment 13)

Figure 13 is that expression is provided with the top outside drawing that present embodiment uses the slow released parts of volatile medicine of humidity sensing film, and Figure 14 is the section structure side view along Figure 13 A-A ' line.The 1st, absorb do medicament with allyl isosulfocyanate after the polyurethane continuous multi-hole body of swelling.Specifically make 60 * 40 * 6 millimeters polyurethane continuous multi-hole bodies (bulk density 0.35 grams per milliliter, 30 microns of average pore diameters, the porosity 70%) absorb approximately swelling to 84 behind the 45 gram allyl isosulfocyanates * 56 * 8.4 millimeters.The 32nd, by this material main body container of filling that translucent polypropylene (2 millimeters of thickness) is made, injection molded processing.The container inside dimension is 90 * 60 * 20 millimeters.The 33rd, the lid of main body container 32, also make by the translucent polypropylene of 2 millimeters of thickness, be provided with big window at lid 33 middle bodies, form cross reinforcement 34 with respect to this big window, lid 33 surperficial side middle bodies are provided with 70 * 40 millimeters humidity sensing film 4, utilize reinforcement 34 that polyurethane continuous multi-hole body 1 is fixed on main body container 32 bottom surface portions, simultaneously humidity sensing film 4 is played enhanced effect.Humidity sensing film 4 is at polyethylene/oriented polypropylene/polyethylene stack membrane superimposed layer the film of viscose rayon paper to be arranged.Specifically, on 40 microns polyethylene/30 micron oriented polypropylenes/40 microns polyethylene films, form viscose rayon aqueous solution (cellulose concentration 6 weight % with 10 grams/square metre coating weight with artificial silk/paper pulp non-woven fabrics, alkali concn 3.3 weight %) after, regenerative sulfur binding in sulfuric acid bath is dried after the washing.Behind 0.2 milliliter of 10 weight % calcium chloride water of spraying on the viscose rayon film, be dried again after temporary transient the placement then.Its as a result the calcium chloride content on the viscose rayon be 0.7 gram/square metre.Viscosity sensitive membrane 4 outer peripheral portions are bonded on the polyethylene side fusion on the lid 33 with heat sealing method.Heat seal width is 3 millimeters.Main body is held 32 and is utilized with lid 33 that ultrasonic wave is legal to be connected.The 5th, by porous polyurethane object 1, main body container 32 with cover 33 formed space segments, this space content is long-pending to be 65 milliliters.

The slow release mechanism of slow released parts of volatile medicine below is described.From the evaporable allyl isosulfocyanate steam of polyurethane continuous multi-hole body, in the space segment 5 vapour pressure concentration that can reach capacity.For example the vapour pressure of 25 ℃ of following allyl isosulfocyanates is about 5 mm Hg, so the saturated vapor concentration maximum in the space segment becomes about 6600ppm.Under the low humidity situation, the steam that discharges to the outside is owing to suppressed by humidity sensing film 4 to a certain extent, so space segment 5 can maintain just near under the saturated vapour pressure CONCENTRATION STATE.In case but humidity increases, the allyl isosulfocyanate steam just sees through humidity sensing film 4 easily and discharges to the outside.Humidity sensing film 4 is the lax structure of a kind of membrane tissue swelling because of humidity becomes, and the allyl isosulfocyanate molecule thereby the easy humidity sensing film that sees through that becomes discharge to the outside.In order to replenish this burst size part, after must volatilizing again, polyurethane continuous multi-hole body 1 evaporable allyl isosulfocyanate steam is full of space segment 5.

(embodiment 14)

The slow released parts of volatile medicine that uses in the present embodiment has identical substantially formation with embodiment 13, thereby omits the explanation to it, only different piece is illustrated.Used at polyethylene/oriented polypropylene/polyethylene superimposed layer the humidity sensing film of viscose rayon paper as humidity sensing film in the present embodiment.Specifically, on 40 microns polyethylene/30 micron oriented polypropylenes/40 microns polyethylene films, form viscose rayon film water solution (cellulose concentration 6 weight % with 10 grams/square metre coating weight with artificial silk/paper pulp non-woven fabrics, alkali concn 3.3 weight %) after, regenerative sulfur binding in sulfuric acid bath is dried after the washing.On the viscose rayon film, behind the aqueous solution of silica gel (Misao Kusano makes, and thinks Nuo Taikesi (ス ノ one テ Star Network ス) N) of spraying 0.5 15 millimeters of mean diameters of gram, 20 weight %, be dried again after the placement a little while then.Its as a result the content of chlorine silica gel on viscose rayon be 3.5 the gram/square metre.

(embodiment 15)

The slow released parts of volatile medicine that uses in the present embodiment has identical substantially formation with embodiment 13, thereby omits the explanation to it, only different piece is illustrated.Used at polyethylene/oriented polypropylene/polyethylene superimposed layer the humidity sensing film of viscose rayon paper as humidity sensing film in the present embodiment.Specifically, on 40 microns polyethylene/30 micron oriented polypropylenes/40 microns polyethylene films, form viscose rayon film water solution (cellulose concentration 6 weight % with 10 grams/square metre coating weight by means of artificial silk/paper pulp non-woven fabrics, alkali concn 3.3 weight %) after, regenerative sulfur binding in sulfuric acid bath is dried after the washing.

With regard to the slow released parts of volatile medicine that embodiment 13,14 and 15 obtains, measured the relation between 25 ℃ of following medicament burst sizes and the humidity sensitive characteristic, it the results are shown among Figure 15.

Figure 15 shows, in embodiment 15, in a single day surpass near 80% relative humidity, the medicament burst size will sharply increase, and characteristic is compared in embodiment 13 and 14 linear characteristic that changes for humidity than embodiment 15 height therewith, and near the medicament burst size 60% relative humidity also can increase.This presentation of results also can be brought into play mildew-proof function effectively near the mycete that is easy to generate 60% relative humidity.And with 20% relative humidity condition under compare, the medicament burst size under 95% relative humidity also can increase, and makes the raising of moisture sensitivity become possibility.

The slow released parts of volatile medicine that embodiment 13,14 is obtained is arranged on the result that internal volume is 1 cubic metre of shoe chest top use, finds can to produce by mould fungus inhibition in one-year age greatly.Though depend on concrete conditions such as the ventilation coefficient of shoe chest and environment for use, in shoe chest, use under the situation of this slow released parts of volatile medicine, even intactly depositing therein, the leather shoes that will pass the rainy day do not produce mycete yet.

(embodiment 16)

Figure 16 is that expression is provided with the top outside drawing that present embodiment uses the slow released parts of volatile medicine of humidity sensing film, and Figure 17 is the section structure side view along B-B ' line among Figure 16, and Figure 18 is the section structure side view along C-C ' line among Figure 16.The 1st, absorb do medicament with allyl isosulfocyanate after the polyurethane continuous multi-hole body of swelling.Specifically make 35 * 71 * 2 millimeters polyurethane continuous multi-hole body (bulk density 0.35 grams per milliliter, 30 microns of average pore diameters, the porosity 70%) absorb approximately swelling to 50 behind the 15.5 gram allyl isosulfocyanates * 100 * 2.8 millimeters.The 19th, the outer package of making polyurethane continuous multi-hole body 1 is with the heat sealed package body of stack membrane, is the poly stack membrane of 9 microns PET/15 micron polypropylene/30 microns is sealed the product of 5 mm wide package cargos in polyethylene side, does a controlling diaphragm use.The 35th, this material of filling main body container of making by transparent polyethylene terephthalate (2 millimeters of thickness), injection molded processing.The container inside dimension is 55 * 140 * 10 millimeters.The 36th, the lid of main body container 35, also be to make by the transparent polyethylene terephthalate of 2 millimeters of thickness, middle body at lid 36 is provided with big window, there are two places to form reinforcement 37 along the longitudinal, be provided with 45 * 130 millimeters humidity sensing film 4 at lid 36 face side middle bodies, with reinforcement 37 internal tank of heat sealed package body 19 is fixed on bottom surface one side, and humidity sensing film 4 is played enhanced effect.Humidity sensing film 4 is a kind of films at polyethylene/oriented polypropylene/polyethylene/PET stack membrane superimposed layer viscose rayon paper.Specifically on 20 microns polyethylene/10 micron oriented polypropylenes/15 microns polyethylene/9 micron PET films, form viscose rayon aqueous solution (cellulose concentration 6 weight % with 10 grams/square metre coating weight with artificial silk/paper pulp non-woven fabrics, alkali concn 3.3 weight %) after, regenerative sulfur binding in sulfuric acid bath is dried after the washing.Behind 0.5 milliliter of 10 weight % lithium bromide water solution of spraying on the viscose rayon film, be dried again after the placement a little while then.Its as a result the lithium bromide content on the viscose rayon be 0.85 gram/square metre.Viscosity sensitive membrane 4 outer peripheral portions are bonded on the fusion of PET side on the lid 36 with heat sealing method.Heat seal width is 3 millimeters.Main body container 35 utilizes with lid 36 that ultrasonic wave is legal to be connected.The 5th, by heat sealed package body 19, main body container 35 with cover 36 formed space segments, this space content is long-pending to be 45 milliliters.

The slow release mechanism of slow released parts of volatile medicine below is described.From polyurethane continuous multi-hole body 1 evaporable allyl isosulfocyanate steam, when its volatile quantity is subjected to stack membrane 19 inhibition, arrive by stack membrane 19 and the film formed space segment 5 of humidity sensitive.For example the vapour pressure of 25 ℃ of following allyl isosulfocyanates is about 5 mm Hg, so the senior general of the saturated vapor concentration in the space segment becomes about 6600ppm, space segment 5 has to a certain degree Concentraton gradient to it when, be full of the allyl isosulfocyanate steam, if the burst size of secondary controlling diaphragm is little, then volatile quantity will increase before to the vapour pressure characteristic of atmosphere gas temperature to a certain degree, and space segment 5 is reached capacity till the vapour pressure concentration substantially.Under the low humidity situation, the allyl isosulfocyanate steam that discharges to the outside is owing to be suppressed to a certain extent, so space segment 5 can maintain just near under the saturated vapour pressure CONCENTRATION STATE.In case but humidity increases, the allyl isosulfocyanate steam just sees through humidity sensing film 4 easily and discharges to the outside.Humidity sensing film 4 becomes the lax structure of membrane tissue swelling because of humidity, and the allyl isosulfocyanate molecule thereby the easy humidity sensing film that sees through that becomes discharge to the outside.In order to replenish this burst size part, must be full of space segment 5 by stack membrane package body 19 again from polyurethane continuous multi-hole body 1 evaporable allyl isosulfocyanate steam.Discharge the speed of allyl isosulfocyanate this moment to the outside from humidity sensing film 4, compare with the allyl isosulfocyanate diffusion velocity that sees through space segment 5 from polyurethane continuous multi-hole body 1 evaporable allyl isosulfocyanate, because the latter is faster, so the burst size of allyl isosulfocyanate can be sufficient.And from the characteristic of slow released parts of volatile medicine release medicine, almost constant reach below the 10 weight % at initial stage up to the allyl isosulfocyanate residual volume before.

Just use below that the indoor set to air conditioner describes under the slow released parts of volatile medicine situation that present embodiment obtains.

Fig. 3 is the cross-section structure of expression present embodiment indoor machine of air conditioner.Suck room airs by sucking grille 6,7, inhaled air on one side by convection fan 10 suction drafts, provides cold wind from final air outlet 11 to the interior space on one side after heat exchanger 8,9 coolings, dehumidifying.Air outlet 11 is provided with the blade 12 of deflection up and down, and control is to the indoor direction that blows out.This moment through the dew of heat exchanger 8,9 dehumidifying attached to the heat exchanger aluminum blades on, flow in the drain pan 13,14.Drain pan 13 constitutes one with Shelf 15, and drain pan 14 constitutes one with air outlet grille 16.Be trapped in dew on the drain pan 13 and flow to drain pan 14 1 sides by frame 15 and hold, finally drain into the outside via the discharge outlet (not shown).In order to make the heat exchange performance high efficiency of heat exchanger 8,9 aluminum blades, its structure is provided with vertical joint-cutting.Therefore agglomerative dew forms moisture film in the joint-cutting part because of surface tension owing to be difficult to drip to drain pan 13,14 immediately on the structure, institute so that the aluminum blades rate of drying slow down.For example under the ambiance of 25 ℃ and 90% relative humidity, the heat exchanger aluminum blades is dry to need tens of hours, is difficult to dry.The indoor set space particularly will be exposed in the atmosphere gas of 95% above relative humidity by the inside, air-supply loop that heat exchanger 8,9 constitutes this moment, form the environmental condition that mycete is very easy to breeding.The 17th, slow released parts of volatile medicine is set at the upstream side near heat exchanger 9 bottoms, constitutes to have the humidity sensing film 4 sides structure relative with heat exchanger that makes slow released parts of volatile medicine 17.So, after refrigeration, dehumidifying running stop, the blade 12 of deflection becomes closed condition up and down, being in air under the high humility state simultaneously, in a single day to be full of indoor set all and arrive at humidity sensing film 4 places, allyl isosulfocyanate will be from slow released parts of volatile medicine 17 inner heat exchanger 9 sides diffusions, when between aluminum blades, passing through, because of deflecting blade 12 up and down be in closed condition slowly the spatial portion that constitutes of heat exchanger 8,9 grade diffusion, accumulate and be full of.Spatial portion that the result is made of heat exchanger 8,9 in indoor set inside bottom just may be detained about 3～5ppm, even also can be detained the allyl isosulfocyanate steam more than the 1ppm in above-mentioned low concentration space.Be trapped in the high concentration allyl isosulfocyanate steam in slow released parts of volatile medicine 17 space segments 5, through the spatial diffusion of humidity sensing film 4 to 500～5000 times.The threshold value of allyl isosulfocyanate is about 10ppm, is under the level of imperceptible fragrance so steam is detained concentration.Therefore, can obtain sufficient anti-mold effect for the general mycete that is called as Cladosporium, Alternaria, Aspergillus, Pencillium and relative humidity izopus that is present in the interior space.In order to obtain the anti-mold effect of indoor set, wish that the allyl isosulfocyanate steam in the indoor set is in more than the 0.5ppm, wish in the practicality to be in below the 10ppm of human threshold value.

(embodiment 17)

The slow released parts of volatile medicine that uses in the present embodiment has identical substantially formation with embodiment 16, thereby omits the explanation to it, only different piece is illustrated.Used at polyethylene/oriented polypropylene/polyethylene/PET superimposed layer the humidity sensing film of viscose rayon paper as humidity sensing film in the present embodiment.Specifically, on 20 microns polyethylene/20 micron oriented polypropylenes/15 microns polyethylene/9 micron PET films, form viscose rayon aqueous solution (cellulose concentration 6 weight % with 10 grams/square metre coating weight by artificial silk/paper pulp non-woven fabrics, alkali concn 3.3 weight %) after, regenerative sulfur binding in sulfuric acid bath, the washing after drying.On the viscose rayon film, behind the aqueous solution of silica gel (Misao Kusano makes, ス ノ one テ Star Network ス N) of spraying 1.25 gram mean diameters 15 sodium rice, 20 weight %, be dried again after the placement a little while then.Its as a result the content of silica gel on viscose rayon be 4.3 the gram/square metre.

(embodiment 18)

The slow released parts of volatile medicine that uses in the present embodiment has identical substantially formation with embodiment 16, thereby omits the explanation to it, only different piece is illustrated.Used at polyethylene/oriented polypropylene/polyethylene/PET superimposed layer the humidity sensing film of viscose rayon paper as humidity sensing film in the present embodiment.Specifically, on 20 microns polyethylene/20 micron oriented polypropylenes/15 microns polyethylene/9 micron PET films, form viscose rayon aqueous solution (cellulose concentration 6 weight % with 10 grams/square metre coating weight by artificial silk/paper pulp non-woven fabrics, alkali concn 3.3 weight %) after, regenerative sulfur binding in sulfuric acid bath, the washing after drying.

With regard to the slow released parts of volatile medicine that embodiment 16,17 and 18 obtains, measured the relation between 25 ℃ of following medicament burst sizes and the humidity sensitive characteristic, it the results are shown among Figure 19.

Figure 19 shows, in embodiment 18, in a single day surpass near 80% relative humidity, burst size will sharply increase, and characteristic is compared in embodiment 16 and 17 linear characteristic that changes for humidity than embodiment 18 height therewith, and near the medicament burst size 60% relative humidity also increases.This presentation of results also can be brought into play mildew-proof function effectively for the mycete that is easy to generate in the lower atmosphere gas of humidity.And with 20% relative humidity under compare, the burst size of medicament also can increase under 95% relative humidity, makes the raising of moisture sensitivity become possibility.

After making the slow released parts of volatile medicine of embodiment 13～18 under 15 ℃ of atmosphere gas temperature and the 50% relative humidity condition, for the non-permeability film that constitutes by 40 microns polyethylene/20 micrometer nylon/7 micron aluminum foils/40 micron polyethylene, after at first three fever sensation of the face envelope being fused with 10 millimeters width, insert slow released parts of volatile medicine, again sealing state is made in the opening portion heat-sealing.In 60 ℃ of calorstats, placed for two weeks then.Then from calorstat, take out the slow released parts of volatile medicine of pack with non-permeability film, be cooled to 30 ℃ after, tear the state of non-permeability film taking-up slow released parts of volatile medicine observation viscose rayon film wherein.Observed result finds that the viscose rayon film of embodiment 13,14,16,17 is for crackle occurring and breaking.But the viscose rayon film of embodiment 15 and 18 has produced the part crackle.This presentation of results, the humidity sensing film surface layer is contained under the situation of hygroscopy material or silica gel, absorb the dampness in the atmosphere gas easily, even in 60 ℃ of atmosphere gas, also can keep the flexibility of viscose rayon film at the dampness of humidity sensing film surface layer moisture absorption.

Though embodiment 13 has used calcium chloride and embodiment 16 to use lithium bromide, that can use in the present invention is not limited to these materials.In addition, can also use lithium chloride, calcium bromide, magnesium bromide, calcium iodide, magnesium iodide, lithium iodide separately or use its mixture.The lip-deep content of humidity sensing film be preferably 0.2～1 the gram/square metre.Be lower than 0.2 gram/square metre the time to make humidity sensing film contain the action effect of hygroscopy material little, even otherwise pounce on the effect of catchmenting part and all became strong if be higher than the hygroscopy material under the low humidity condition of 1 gram/square metre then, make humidity sensing film forfeiture linear characteristic, become curve, near the burst size of medicament 60% relative humidity is more than aequum, thereby bad.In addition, in the following low humidity scope of 20% relative humidity, hygroscopy substance crystallization powder also breaks away from from humidity sensing film easily.

In embodiment 14 and 17, utilize to make the surface layer of humidity sensing film disperse carrier band silica gel the spray-dired method of aqueous solution of silica gel.For the dampness to pounce on collection supply environment atmosphere gas as the viscose rayon film of humidity sensitive membrane matrix in effectively, silica gel preferably has the pore diameter of 10～100 dust average pore sizes.And preferably make the humidity sensing film surface contain 0.5～5 the gram/square metre.Be lower than 0.5 the gram/square metre the time, the action effect of desiring to make humidity sensing film contain the hygroscopy material is little, and greater than 5 grams/square metre the time hygroscopy material to pounce on the effect of catchmenting part strong excessively, the linear characteristic forfeiture of humidity sensing film, become curve, near the burst size of medicament 60% relative humidity is more than aequum, thereby bad.

Though used the continuous poriferous bulk absorption of polyurethane to keep volatile medicine in the present embodiment specially, can freely volatile medicine have been held among the article body that is filled under any form in the present invention.Generally speaking, make liquid preparation as present embodiment, be absorbed on the liquid absorbent material, perhaps add the soluble high-molecular material in medicament, for example ethyl cellulose, butyral resin etc. make it thickening or solidify the back to use, and can improve the operability when making slow released parts of volatile medicine.

Though used polypropylene and poly composite membrane as medicament volatile quantity controlling diaphragm in the present embodiment, that can use in the present invention is not limited to this.The all right in addition thin film that uses polyethylene film, polypropylene screen, polyurethane film, nylon membrane, polyethylene terephthalate film separately or its compound back is used laminated construction.

In the present embodiment, though special-purpose allyl isosulfocyanate, that can use in the present invention is not limited to this.Can also use tea tree oil or Eucalyptus oil.And so long as can under the low concentration volatile quantity, obtain antibiotic and medicament anti-mold effect, can use as the medicament of slow released parts of volatile medicine of the present invention.

In the present embodiment, though used the non-permeability film of the film conduct of polyethylene/nylon/aluminium foil/polyethylene structure to medicament, that can use in the present invention is not limited to this.Generally speaking, can use with about 5～10 microns aluminium foil and make the laminated construction film of internal layer as non-permeability film.And with these stack membranes with enough heat seal width (for example 10 millimeters) along under the situation of four direction heat-sealing back packing, can preserve slow released parts of volatile medicine for a long time.

Claims (8)

1, a kind of slow released parts of volatile medicine is characterized in that having the liquid absorbent material that absorbs the maintenance liquid preparation; The volatile quantity controlling diaphragm of the described medicament volatile quantity of control in the described liquid absorbent material outer package; The humidity sensing film that described medicament transmitance changes with humidity, the space segment that evaporable described medicament steam is detained usefulness is set between described volatile quantity controlling diaphragm and described humidity sensing film, make the volatilization of described medicament and in described space segment, remain on below certain vapor concentration, the described medicament that is trapped in the described space segment is changed according to outside humidity environment slowly discharge to the outside from described humidity sensing film; Described liquid absorbent material is the continuous multi-hole body of polyurethane, polypropylene, polyethylene or polyvinyl alcohol, described volatile quantity controlling diaphragm is polyethylene film, polypropylene screen, polyurethane film, nylon membrane, polyethylene terephthalate film or its composite laminate film, and described humidity sensing film is that the surface comprises the laminated construction that the viscose rayon converted paper forms.

2, according to the described slow released parts of volatile medicine of claim 1, it is characterized in that wherein said liquid absorbent material is a continuous multi-hole body, be in more than 200% with respect to the volume swelling rate of described medicament.

3, according to the described slow released parts of volatile medicine of claim 1, it is characterized in that wherein the average pore diameter as the continuous multi-hole body of described liquid absorbent material is 10～100 microns, the porosity is 50～90%.

4,, it is characterized in that wherein said medicament is allyl isosulfocyanate, tea tree oil or Eucalyptus oil according to the described slow released parts of volatile medicine of claim 1.

5, according to the described slow released parts of volatile medicine of claim 1, the burst size that it is characterized in that wherein said medicament is 20～200 milligrams/day under 30 ℃ and 95% relative humidity.

6, according to the described slow released parts of volatile medicine of claim 1, the burst size that it is characterized in that wherein said medicament is below 10 milligrams/day under 30 ℃ and 30% relative humidity.

7,, it is characterized in that it being a kind of container that can see the decrement state that described medicament decrement changes from the outside according to the described slow released parts of volatile medicine of claim 1.

8, according to the described slow released parts of volatile medicine of claim 1, it is characterized in that its structure is, the upper surface of described humidity sensing film is deposited with non-permeability film, during use described non-permeability film is peeled off and can expose described humidity sensing film.

Images