CN1241650C - Volatile chemical slow-releasing unit and air conditioner using the unit - Google Patents
Volatile chemical slow-releasing unit and air conditioner using the unit Download PDFInfo
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- CN1241650C CN1241650C CNB200410000663XA CN200410000663A CN1241650C CN 1241650 C CN1241650 C CN 1241650C CN B200410000663X A CNB200410000663X A CN B200410000663XA CN 200410000663 A CN200410000663 A CN 200410000663A CN 1241650 C CN1241650 C CN 1241650C
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- medicament
- film
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- released parts
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- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04G—SCAFFOLDING; FORMS; SHUTTERING; BUILDING IMPLEMENTS OR AIDS, OR THEIR USE; HANDLING BUILDING MATERIALS ON THE SITE; REPAIRING, BREAKING-UP OR OTHER WORK ON EXISTING BUILDINGS
- E04G1/00—Scaffolds primarily resting on the ground
- E04G1/18—Scaffolds primarily resting on the ground adjustable in height
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- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04G—SCAFFOLDING; FORMS; SHUTTERING; BUILDING IMPLEMENTS OR AIDS, OR THEIR USE; HANDLING BUILDING MATERIALS ON THE SITE; REPAIRING, BREAKING-UP OR OTHER WORK ON EXISTING BUILDINGS
- E04G1/00—Scaffolds primarily resting on the ground
- E04G1/24—Scaffolds primarily resting on the ground comprising essentially special base constructions; comprising essentially special ground-engaging parts, e.g. inclined struts, wheels
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- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04G—SCAFFOLDING; FORMS; SHUTTERING; BUILDING IMPLEMENTS OR AIDS, OR THEIR USE; HANDLING BUILDING MATERIALS ON THE SITE; REPAIRING, BREAKING-UP OR OTHER WORK ON EXISTING BUILDINGS
- E04G1/00—Scaffolds primarily resting on the ground
- E04G1/24—Scaffolds primarily resting on the ground comprising essentially special base constructions; comprising essentially special ground-engaging parts, e.g. inclined struts, wheels
- E04G2001/242—Scaffolds movable on wheels or tracks
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- Architecture (AREA)
- Mechanical Engineering (AREA)
- Civil Engineering (AREA)
- Structural Engineering (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
- Air Filters, Heat-Exchange Apparatuses, And Housings Of Air-Conditioning Units (AREA)
Abstract
A liquid chemical is filled in a concave container and a lid material. The container comprises a sheet sandwiching an ethylene vinylalcohol copolymer film between polyethylene or polypropylene. The lid material comprises a humidity sensitive film provided on the surface of a polyethylene or polypropylene film. The polyethylene or polypropylene film of the lid material is thermally welded and attached to the polyethylene or polypropylene layer of the container. The controlled release member for the volatile chemical slowly releases the chemical while the humidity sensitive film controls the amount of the volatilized chemical in response to humidity.
Description
Technical field
The invention relates to the slow released parts of volatile medicine that slowly discharges volatile medicine according to the variation of outside humidity environment, these parts can be widely used in preventing because the variation of changes of seasons or ambiance humidity causes the place of mycete and bacteria breed and procreation, for example can be used for humidification that bathroom, dressing cubicle, geta case, pantry, storehouse, ground storage or building air-conditioning use with path, ventilation with path etc., it is very effective particularly often being maintained in the clean condition behind the indoor set cooling operation for air conditioner.
Background technology
About discharging the technology of the liquid material that is filled over a long time lentamente, various schemes were proposed once in the past.Common method is, this liquid material is infiltrated up in the porous material, utilizes capillarity to make its effusion of volatilizing lentamente.Described porous material is the inorganic compound of zeolite, silica gel and so on, or polypropylene, polyester, cellulosic foaming body or fibre bundle.In addition, the somebody has proposed Jiang Qibao and has been connected on the method that makes it slow release in the organic aperture that is called as cyclodextrin.Above-mentioned technology contents is documented in the spy and opens in flat 5-176733 communique and the flat 6-40890 communique of Te Kai.
In addition, disclose in the following document by micro encapsulation and realize the method that slowly discharges: the spy opens flat 6-9377 communique, spy and opens flat 6-65064 communique, spy and open that flat 7-89848 communique, spy are opened flat 9-911 communique, the spy opens flat 9-12447 communique and the flat 9-57091 communique of Te Kai.
In addition, open in clear 55-57502 communique and the clear 63-240738 communique of Te Kai the spy and to disclose a kind of method, promptly, as method commonly used in anthelmintic field or aromatic field, occasion using absorber heats this absorber with heater, with further raising evaporation rate.
But, when adopting these in the past technical schemes, can not stably slowly discharge the performance medicament of low concentration along with the variation of outside humidity environment.The liquid measure of medicament is more when initial, and the volatile quantity of medicament is bigger, and As time goes on, the amount of medicament reduces gradually, and burst size also reduces thereupon, thereby has volatile quantity or the uneven problem of burst size.
Summary of the invention
The present invention be directed to above-mentioned prior art problems finishes, the invention relates to can low concentration the average and lentamente slow released parts of volatile medicine of release medicine steam of rate of release, change owing to can fully adapt to humidity, thereby can suppress unnecessary release.In addition, because volatile ingredient discharges diffusion at twice lentamente from parts, even the liquid measure of medicament reduces, escaped quantity also is not easy to be affected.In addition, even be exposed under the logistics environment under the condition of high temperature, can not worry owing to peel off the release causing of the medicament under the packed state joint portion of parts yet.
Slow released parts of volatile medicine of the present invention, structure with filling liquid medicament in forming matrix shapes of containers and lid, described container is the thin plate that clips the co-polymer membrane of ethylene-vinyl alcohol combined polymerization with polyethylene or polypropylene, described lid is that configuration constitutes the film of humidity sensitive on the surface of polyethylene film or polypropylene screen, the polyethylene film of above-mentioned lid or polypropylene screen are connected with the polyethylene layer or the polypropylene layer heat fused of said vesse, and above-mentioned moisture sensitivity film makes it slow release according to the volatile quantity of humidity situation control medicament.
Description of drawings
Fig. 1 is the front appearance figure of the slow released parts of volatile medicine of embodiment 1.
Fig. 2 A is the side cross-section structure of the slow released parts of volatile medicine of embodiment 1.
Fig. 2 B is the view of thickness direction of having given prominence to Fig. 2 A of embodiment 1.
Fig. 3 is the curve chart of the allyl isosulfocyanate release characteristics of the slow released parts of volatile medicine that obtains of expression embodiment 1.
Fig. 4 is the indoor set cross-section structure of the air conditioner of embodiment 1.
The specific embodiment
Embodiments of the invention are described with reference to the accompanying drawings.
Embodiment 1
Fig. 1 is the front appearance figure of the slow released parts of volatile medicine 17 of expression present embodiment, and Fig. 2 A and Fig. 2 B represent the section structure of slow released parts of volatile medicine 17.For the configuration of each component parts clearly is described, Fig. 2 B is expressed as the thickness of each component parts to be given prominence to more than the actual value.
The inside dimension of container 1 is 50 * 140 * 10mm, and it makes the coextrusion sheet material vacuum mo(u)lding of thickness 0.8mm.The coextrusion sheet material is made of cast polypropylene (CPP, thick 370 μ m)/ethylene-vinyl alcohol copolymer (EVOH, thick 60 μ m)/CPP (thick 370 μ m).Volatile medicine 2 is the flakelets that the solid shapeization of chemical substance allyl isosulfocyanate obtained with cellulosic ether.When making this flakelet, in the mold container, add powder (day newly changes into ェ ト セ Le STD-100, the weight average molecular weight 180,000) 7.5g of cellulosic ether, again to wherein adding ethanol 15g, place and add allyl isosulfocyanate 15g after 1 hour, at room temperature placed 48 hours.In this process, ethanol evaporation, allyl isosulfocyanate by cellulosic ether by sheet.The medicated pillow package body 3 of the stack membrane of the volatilization controlling diaphragm of formation allyl isosulfocyanate is first Breathable films, is used as controlling diaphragm one time.That is, one time controlling diaphragm is, the LDPE side heat-sealing that being configured in of the stack membrane of oriented polypropylene (OPP, thick 30 μ m) and polyethylene (LDPE, thick 70 μ m) is the inboard and thin slice of resulting 40 * 120 * 4mm is made the package body of medicated pillow packing.In the above-mentioned stack membrane that forms a controlling diaphragm, add the titania powder of 5 weight %.
The following describes lid 40.Shown in Fig. 2 B, lid 40 is by the stack membrane 41 that is connected with container, constitutes as the adhesive film 45 that is fitted in the non-woven fabrics 43 on the stack membrane 41 and is coated on the non-woven fabrics 43 of second Breathable films.The lid 40 that is made of said structure is used as the secondary controlling diaphragm.Moisture sensitivity film 4 is the films that form viscose on the surface of viscose glue converted paper, and it is to be made of non-woven fabrics 43 and adhesive film 45.Lid 40 uses at CPP film (thick 40 μ m)/LDPE film (thick 15 μ m) and upward is situated between by artificial silk/paper pulp non-woven fabrics with 7g/m
2Coating weight form the structure of adhesive film.The peripheral part of lid 40 (the A portion of Fig. 2 B) is by with PP side heat-sealing, be fused on the container 1 with the width of 5mm.Stack membrane 3 forms spatial portion 5 with lid 40.The space content of spatial portion 5 is long-pending to be 40mL.Medicated pillow package body 3 by stack membrane constitutes is fixed on the inner surface bottom of container 1 by making LDPE hot melt (not shown).
By the allyl isosulfocyanate steam that flakelet 2 volatilizations are overflowed, its volatile quantity is subjected to the inhibition of stack membrane 3, enters in the spatial portion 5 that is formed by stack membrane 3 and lid 40.For example, are about 5mmHg in the vapour pressure of 25 ℃ of following allyl isosulfocyanates, a therefore controlling diaphragm inside promptly about 6600PPm of vapor concentration that reaches capacity immediately.Space 5 has corresponding with it Concentraton gradient, is full of the allyl isosulfocyanate steam.Therefore, if the amount of overflowing from the secondary controlling diaphragm is less, volatile quantity will increase until reaching and to a certain degree the corresponding vapour pressure characteristic of ambient temperature, and final, the allyl isosulfocyanate steam is full of the vapour pressure concentration that roughly reaches capacity in spatial portion 5.In the occasion of low humidity, the steam that allyl isosulfocyanate discharges to the outside is owing to be subjected to the inhibition of moisture sensitivity film 4 to a certain extent, and therefore, spatial portion 5 is kept closer to the state of saturated vapour pressure concentration.
But when humidity raise, the allyl isosulfocyanate steam was discharged into the outside by moisture sensitivity film 4 easily, variation along with humidity, the membrane tissue swelling of moisture sensitivity film 4 becomes the structure of absent-mindedness, and the allyl isosulfocyanate molecule sees through easily and escapes into the outside.In order to replenish this escaped quantity, the allyl isosulfocyanate steam that is discharged by flakelet 2 must further pass through stack membrane 3, is filled in the spatial portion 5.See through moisture sensitivity film 4 is discharged allyl isosulfocyanate to the outside by spatial portion 5 speed, with see through the evaporation rate that stack membrane 3 escapes in the spatial portion 5 by flakelet 2 evaporable allyl isosulfocyanates and compare, the latter's speed is faster, thereby the burst size of allyl isosulfocyanate can be sufficient.Adopt the slow released parts of volatile medicine 17 of this formation, under the relative humidity condition of 30 ℃ temperature and 95% can with the level of 100mg/ day by moisture sensitivity film 4 in release medicine constantly.In addition, medicament discharges the characteristic of overflowing from slow released parts of volatile medicine 17, and is constant basically reach below the 10 weight % of initial pharmaceutical quantities in the residual quantity of allyl isosulfocyanate before.The allyl isosulfocyanate release characteristics of the slow released parts of volatile medicine 17 that obtains by embodiment 1 shown in Fig. 3.
The following describes the packaged configuration of slow released parts of volatile medicine 17 before Kaifeng on the market.Constituting the slow released parts of volatile medicine 17 that obtains by above-mentioned, is to pack the back with non-Breathable films to preserve.Described non-Breathable films is the laminated construction that is made of LDPE (thick 40 μ m)/nylon (thick 20 μ m)/aluminium foil (thick 7 μ m)/LDPE (thick 40 μ m), and it is of a size of 200 * 100mm.At first, adopt the width of heat-sealing with its 3 edge heat-sealing 10mm, then under 15 ℃, the operating environment of 30%PH (absolute humidity 3.2g/kg (DA)), the water droplet of slow released parts of volatile medicine 17 with 4mg inserted in the non-Breathable films, adopt the width of heat-sealing at last peristome heat fused 10mm.To in 60 ℃ calorstat, place 3 months with the slow released parts of volatile medicine 17 that this non-Breathable films is packed.Then, by the slow released parts of volatile medicine 17 that takes out packing in the calorstat, be cooled to 30 ℃ after, break non-Breathable films, take out slow released parts of volatile medicine 17, observe its preservation condition.As a result, even in the A portion (Fig. 2 B) of peeling off easily usually, also do not observe lid 40 and peel off from container 1, breakages such as be full of cracks take place also on the adhesive film 45 of formation moisture sensitivity film 4.
The following describes the example that in the indoor set of air conditioner, uses the slow released parts of volatile medicine 17 of present embodiment 1.
Fig. 4 is the profile of indoor set of the air conditioner of expression present embodiment.Suck room airs by sucking grid 6,7, inhaled air is after over-heat-exchanger 8,9 coolings, dehumidifying, and one side is by cross-flow fan 10 suction drafts, and one side provides cold wind from final blow-off outlet 11 to the interior space.Deflecting blade 12 up and down is set on blow-off outlet 11, and control is to the direction of interior space air-supply.At this moment, arrive drain pan part 13,14 through the dew of heat exchanger 8,9 dehumidifying along the aluminium radiator fin of heat exchanger.Drain pan part 13 forms as one with the support 15 of indoor set, drain pan part 14 with blow out grid 16 and form as one.The dew of accumulating in drain pan part 13 flows to drain pan part 14 sides through support 15, is discharged to the outside through the discharge outlet (not shown) at last.In order to improve the efficient of heat exchange, on the aluminium radiator fin of heat exchanger 8,9, longitudinal cut is set.Therefore, the water of dewfall, is difficult to drip to drain pan part 13,14 immediately owing to capillary effect forms moisture film at notch, causes the rate of drying of aluminium radiator fin to become slow.For example, in the ambiance of the relative humidity of 25 ℃ temperature and 90%, the aluminium radiator fin of heat exchanger is dry to need tens hours, is not easy very much drying.
At this moment, the inside, air-supply loop that the indoor set space particularly is made of heat exchanger 8,9 is in relative humidity 95% or the atmosphere more than it, and mycete is very easy to breeding under this environmental condition.Slow released parts of volatile medicine 17 is configured in the bottom upstream side that approaches heat exchanger 9, and moisture sensitivity film 4 sides of slow released parts of volatile medicine 17 are just in time relative with heat exchanger.Adopt this structure, through process described below, the allyl isosulfocyanate steam is full of the inner space of indoor set.That is, (1) after refrigeration, dehumidifying running stopped, when deflecting blade 12 became closed condition up and down, the air that becomes the high humility state was full of whole indoor set.(2) when the air of high humility state arrived moisture sensitivity film 4, allyl isosulfocyanate was from the inside heat exchanger 9 side gas phase diffusion of slow released parts of volatile medicine 17.(3) by the allyl isosulfocyanate in the inner space that is diffused into indoor set between the aluminium radiator fin, because up and down deflecting blade 12 becomes closed condition, slowly spread to the spatial portion that constitutes by heat exchanger 8,9, gas is accumulated gradually and is full of this spatial portion.
Through said process, even the allyl isosulfocyanate steam that can be detained in the bottom, the space that is made of heat exchanger 8,9 of indoor set inside about 3～5PPm also can be detained 1PPm or more allyl isosulfocyanate steam at upper space.That is, slow released parts of volatile medicine 17 be trapped in high concentration allyl isosulfocyanate steam in the spatial portion 5, see through moisture sensitivity film 4, gas phase diffusion to count 500～5000 times space with volumetric ratio in.Because the people can feel that the threshold value of abnormal smells from the patient of allyl isosulfocyanate is about 10PPm, thereby the concentration of using in the present embodiment is that the steam that the people can not feel the level of its abnormal smells from the patient is detained concentration.Like this, can obtain enough mould proof effects for common mycetes such as the Blastocladia that exists in the interior space, Alternaria, aspergillus, Penicillium, Rhizopus.In order to obtain mould proof effect in indoor set, the allyl isosulfocyanate steam of delay for practicality, preferably feels that the people threshold value of abnormal smells from the patient is 10PPm or lower at 0.5PPm or higher relatively good.Therefore, preferably 1: 500～5000 times of the ratios of the spatial portion 5 of the delay of the inner medicament steams that constitute of slow released parts of volatile medicine 17 and indoor set volume inside volume.
In embodiment 1, only on one side, disposed the moisture sensitivity film 4 of slow released parts of volatile medicine 17, and stream interface is relative in the suction of these moisture sensitivity film 4 sides and heat exchanger.Consider the occasion of changing slow released parts of volatile medicine 17 when medicament exhausts, take off the heat exchanger upstream side that sucks grid 7 from being convenient to the angle consideration that user is safeguarded, preferably being configured in.In addition, in order fully to effectively utilize medicament and to make it rapid release, preferably adopt the such structure of present embodiment 1.
In embodiment 2, allyl isosulfocyanate 15g and cellulosic ether are mixed by 4: 1 weight ratio, tackify is to viscosity 100, and 000CPS transfers in the groove of calcium carbonate powder then, forms bulk.Then, the mixture that forms bulk is filled in the medicated pillow package body 3 of stack membrane similarly to Example 1.For the stack membrane of OPP30 μ m and LDPE70 μ m, the heat-sealing of LDPE side is formed the medicated pillow packing, obtain the medicated pillow package body 3 of 40 * 125 * about 4mm.This stack membrane has first Breathable films, as a controlling diaphragm.Hold the container 1 of medicated pillow package body 3 as slow released parts of volatile medicine 17 and comprise the formation and the embodiment 1 of lid 40 of moisture sensitivity film 4 roughly the same,, medicated pillow package body 3 is fixed on the inner surface bottom of container by with the LDPE hot melt.The size of the spatial portion that is provided with between controlling diaphragm and secondary controlling diaphragm (lid) is designed to 40mL too.
In embodiment 3, allyl isosulfocyanate 15g and cellulosic ether are mixed by 8: 1 weight ratio, tackify is to viscosity 20, and 000CPS transfers in the groove of aluminium-hydroxide powder then, forms bulk.Then, the mixture that forms bulk is filled in the medicated pillow package body 3 of stack membrane similarly to Example 1.The medicated pillow package body 3 of stack membrane forms a controlling diaphragm, for the stack membrane (first Breathable films) of OPP (thickness 30 μ m) and LDPE (thickness 70 μ m), the heat-sealing of LDPE side is formed the medicated pillow packing, obtains the medicated pillow package body of 40 * 125 * about 4mm.Hold the container 1 of medicated pillow package body 3 as slow released parts of volatile medicine 17 and comprise the formation and the embodiment 1 of lid (secondary controlling diaphragm) 40 of moisture sensitivity film 4 roughly the same, by with the LDPE hot melt, medicated pillow package body 3 is fixed on the inner surface bottom of container 1.The size of the spatial portion that is provided with between as the lid 40 of the medicated pillow package body 3 of a controlling diaphragm and secondary controlling diaphragm is designed to 40mL too.
The slow released parts of volatile medicine 17 that embodiment 2 and 3 is obtained is packaged in the non-Breathable films under condition similarly to Example 1.Then, the slow released parts of volatile medicine of packing with non-Breathable films 17 was placed 3 months in 60 ℃ calorstat.Then, from calorstat, take out the slow released parts of volatile medicine of packing with non-Breathable films 17, be cooled to 30 ℃ after, break non-Breathable films, taking-up slow released parts of volatile medicine 17 is observed its state.As a result, lid 40 is not peeled off from container 1, and the two does not produce breakages such as be full of cracks simultaneously in conjunction with good yet on the adhesive film 45.
In embodiment 1, because allyl isosulfocyanate is made into flakelet, be filled in the medicated pillow package body 3 as a controlling diaphragm, thereby when the allyl isosulfocyanate volatilization and pharmaceutical quantities when reducing, the tablet that forms flakelet roughly shrinks equably.In addition, in stack membrane, in order to improve the lubricity that flakelet is shunk smoothly, adding titanium dioxide is effective method.Relative therewith, in embodiment 2 and 3, the dough that forms with the lining of inorganic powder particle after the tackify is not shunk attached to a controlling diaphragm.Therefore, medicament is in vapor liquid equilibrium often a controlling diaphragm inside, the concentration of medicament steam is stablized, when the pharmaceutical quantities minimizing, when a controlling diaphragm volume inside volume slowly increases, as long as the interior volume specific ratio of the spatial portion 5 that is provided with between controlling diaphragm and secondary controlling diaphragm is big the inner spatial volume that forms of controlling diaphragm, because the concentration that spatial portion 5 causes over time change just can be suppressed at very little degree.In addition, user changes according to the volume contraction of flakelet shape or bulk, just can find that from container 1 side that the coextrusion sheet material of CPP/EVOH/CPP constitutes the quantity of medicament reduces and variation.
Cellulosic ether be with refined pulp as raw material, make it alkali celluloseization with caustic soda after, with the ethyl chloride reaction hydroxyl in the glucose is replaced as ethyoxyl and the product that forms, this chemical reaction is represented by formula 1 (Eq.1).Its outward appearance is the powder of white, has the characteristic of odorless basically.For the present invention, the action effect of cellulosic ether promptly, makes the effect of solid shapeization of medicament or tackifyization depend on its weight average molecular weight, specifically, and its weight average molecular weight preferably 100,000 or more than it.In addition, the weight ratio of allyl isosulfocyanate and cellulosic ether can be consolidated shapeization at 2: 1 o'clock.Along with the increase of the weight ratio of allyl isosulfocyanate, viscosity slowly reduces, and when the weight ratio of allyl isosulfocyanate surpasses 10: 1, compares with allyl isosulfocyanate stock solution, and viscosity is not significantly increased.The tackifyization of indication is meant viscosity 5 among the present invention, 000CPS or higher.In addition, by around the mixture of tackify, using inorganic powder particle lining formation bulk, can improve the processing of mixture, simultaneously, can reduce at the inner medicament of filling of controlling diaphragm, when the change of shape of mixture, can not be bonded on controlling diaphragm, thereby can shrink smoothly.Therefore, the weight ratio of allyl isosulfocyanate and cellulosic ether is preferably 2: 1～10: 1.
In embodiment 4, allyl isosulfocyanate is made flakelet with polyvinyl butyral resin.At first, in the mold container, add polyvinyl butyral resin (hydrops chemical industry, ェ ス レ Star Network B:BH-S, weight average molecular weight 140,000, hydroxyl 22% (mole), 73 moles of % of butyralization degree) 7.5g, add ethanol 15g then, placed 30 minutes.Then add allyl isosulfocyanate 15g, at room temperature placed 48 hours.By this processing, ethanol evaporation, allyl isosulfocyanate forms flakelet by polyvinyl butyral resin, and size is 40 * 120 * 4mm.The flakelet of making like this is filled in the medicated pillow package body 3 of stack membrane similarly to Example 1.The medicated pillow package body 3 that is made of stack membrane is as a controlling diaphragm.Stack membrane is that OPP (thick 30 μ m) and LDPE (thick 70 μ m) lamination are formed, and the heat-sealing of LDPE side is formed the medicated pillow packing.In the above-mentioned stack membrane (first Breathable films) that forms a controlling diaphragm, add titania powder 5% (weight).In slow released parts of volatile medicine 17, the container 1 that holds medicated pillow package body 3 is with high density polyethylene (HDPE) (HDPE, thick 450 μ m)/and coextrusion sheet material (thickness 1.0mm) vacuum mo(u)lding of EVOH (thick 100 μ m)/HDPE (thick 450 μ m) makes, and inside dimension is 50 * 140 * 10mm.Forming the lid 40 of secondary controlling diaphragm, is to go up by artificial silk/paper pulp non-woven fabrics, with 7g/m at HDPE film (thickness 100 μ m)
2Coating weight form adhesive film and make.Medicated pillow package body 3 is fixed on the inner surface bottom of container 1 by making the LDPE hot melt.The size of the spatial portion that is provided with between controlling diaphragm and secondary controlling diaphragm is designed to 40mL too.
In present embodiment 5, allyl isosulfocyanate 15g and polyvinyl butyral resin are mixed by 4: 1 weight ratio, make it tackify after, transfer in the groove of titania powder, form bulk.The mixture that forms bulk is filled in similarly to Example 1 the medicated pillow package body 3 that is made of stack membrane.As a controlling diaphragm,, the medicated pillow packing is carried out in the heat-sealing of LDPE side with the medicated pillow package body 3 of stack membrane (first Breathable films), obtain the medicated pillow package body 3 of 40 * 125 * about 4mm for the stack membrane of OPP (thickness 30 μ m) and LDPE (thickness 70 μ m).The formation and the embodiment 1 that hold the container 1 of medicated pillow package body 3 and moisture sensitivity film 4 as slow released parts of volatile medicine 17 are roughly the same, and medicated pillow package body 3 is by on the inner face bottom that the LDPE hot melt is fixed on container 1.The size of the spatial portion that is provided with between controlling diaphragm and secondary controlling diaphragm is designed to 40mL too.
In present embodiment 6, allyl isosulfocyanate 15g and polyvinyl butyral resin are mixed by 8: 1 weight ratio, make it tackify, transfer to then in the groove of Talcum powder, form bulk.The mixture that will form bulk then is filled in the medicated pillow package body 3 of stack membrane similarly to Example 1.As a controlling diaphragm,, the medicated pillow packing is carried out in the heat-sealing of LDPE side with the medicated pillow package body 3 of stack membrane (first Breathable films), obtain the medicated pillow package body 3 of 40 * 125 * about 4mm for the stack membrane of OPP (thickness 30 μ m) and LDPE (thickness 70 μ m).Slow released parts of volatile medicine 17 is to be made of container 1 that holds medicated pillow package body 3 and the lid 40 that comprises moisture sensitivity film 4, and this and embodiment 1 are roughly the same.Medicated pillow package body 3 is by on the inner face bottom that the LDPE hot melt is fixed on container 1.The size of the spatial portion that is provided with between controlling diaphragm and secondary controlling diaphragm is designed to 40mL too.
Polyvinyl butyral resin is the product that makes polyvinyl alcohol and butyraldehyde reaction, and its chemical equation is represented by formula 2 (Eq.2).In the reaction of this butyralization, butyral can not be transformed into fully, the highlyest in the past 81.6% (mole) can only be reached.When the mole % of the hydroxyl that left behind when failing butyralization was big, the intermiscibility variation with allyl isosulfocyanate can not obtain needed effect.Therefore, operable in the present invention polyvinyl butyral resin, its weight average molecular weight is preferably 100,000 or more than it, and the hydroxyl in the molecule is at 25 moles of % or below it, and the butyralization degree in the molecule is preferably at 70 moles of % or more than it.More preferably, hydroxyl is 20～25 moles of %, and the butyralization degree in the molecule is 70～80 moles of %.
In addition, the weight ratio of polyvinyl butyral resin and allyl isosulfocyanate is set at 2: 1 can consolidates shapeization, weight ratio increase along with allyl isosulfocyanate, viscosity slowly reduces, the weight ratio of allyl isosulfocyanate was greater than 10: 1 o'clock, compare with allyl isosulfocyanate stock solution, year is not significantly increased.Tackifyization described in the present invention is meant viscosity 5,000CPS or more than it.In addition, being covered with the inorganic powder particle on every side of mixture in tackifyization forms bulk, can improve the processing of mixture and reduce,, thereby can shrink smoothly even when the change of shape of mixture, also can not be bonded on controlling diaphragm at the inner medicament of filling of controlling diaphragm.According to the above, polyvinyl butyral resin is more suitable at 2: 1～10: 1 with respect to the mixed weight ratio of allyl isosulfocyanate.
Under condition similarly to Example 1, the slow released parts of volatile medicine 17 that embodiment 4,5,6 is obtained is packaged in the non-Breathable films.Then, will in 60 ℃ of calorstats, place 3 months with the slow released parts of volatile medicine 17 that non-Breathable films is packed.Then, by taking out the slow released parts of volatile medicine of packing with non-Breathable films 17 in the calorstat, break non-Breathable films after being cooled to 30 ℃, taking-up slow released parts of volatile medicine 17 is observed its state.As a result, lid 40 is not peeled off from container 1, in conjunction with good, simultaneously, does not produce breakages such as be full of cracks on the adhesive film 45 yet.
In these embodiments, with being covered with calcium carbonate, aluminium hydroxide, titanium dioxide, Talcum powder behind the allyl isosulfocyanate tackify, form bulk, but operable inorganic powder particle is not limited to these among the present invention.So long as good for controlling diaphragm sliding, along with pharmaceutical quantities reduce and when shrinking dough smoothly plastic deformation get final product.In addition, in order to improve the sliding of inorganic powder particle, its mean diameter is at 5 μ m or be advisable below it, preferably 1 μ m or below it.
In present embodiment 7, allyl isosulfocyanate is adsorbed on the polyurethane continuous multi-hole body, make it swelling.At this moment, in allyl isosulfocyanate, add the antioxidant of 2 weight %.Specifically, make the continuous poriferous bulk absorption allyl isosulfocyanate of the polyurethane 15g of bulk density 0.35g/mL, average pore footpath 30 μ m, the porosity 70%, size 28 * 90 * 2.5, swelling is into about 40 * 125 * 3.5.Then, the polyurethane continuous multi-hole body of swelling is filled in similarly to Example 1 the medicated pillow package body 3 that constitutes by stack membrane.As a controlling diaphragm,, the medicated pillow packing is carried out in the heat-sealing of LDPE side with the stack membrane of medicated pillow package body 3 for the stack membrane of OPP (thickness 30 μ m) and LDPE (thickness 70 μ m).Slow released parts of volatile medicine 17 is to be made of container 1 that holds medicated pillow package body 3 and the lid 40 that comprises moisture sensitivity film 4, and this is roughly the same with embodiment 1, medicated pillow package body 3 bottom the inner face that the LDPE hot melt is fixed on container 1 on.The size of the spatial portion that is provided with between controlling diaphragm and secondary controlling diaphragm is designed to 40mL too.
Under condition similarly to Example 1, the slow released parts of volatile medicine 17 that embodiment 7 is obtained is packaged in the non-Breathable films.To in 60 ℃ of calorstats, place 3 months with the slow released parts of volatile medicine 17 that non-Breathable films is packed.Then, by taking out the slow released parts of volatile medicine of packing with non-Breathable films 17 in the calorstat, break non-Breathable films after being cooled to 30 ℃, taking-up slow released parts of volatile medicine 17 is observed its state.As a result, lid 40 is not peeled off from container, in conjunction with good, simultaneously, does not also produce breakages such as be full of cracks on the adhesive film 45.
In present embodiment 7, used the continuous multi-hole body of polyurethane, but the material that can be used for this purpose among the present invention is not limited thereto, so long as can adsorb and keep aqueous medicament and the adequately expanded material of volume does not all have special problem.Even also can keep original shape of continuous multi-hole body when preferably long-term absorption, maintenance volatile medicine, along with maintained pharmaceutical quantities reduces and the slow material that shrinks.In addition, the objective of the invention is to discharge the material that constitutes by plants essential oil etc. lentamente with low concentration, thereby, if ask that any material is good, the still good material liquid conservation rate height of lipophile certainly, thereby preferably selected for use.Specifically, as the physical characteristic of continuous multi-hole body, wish that average pore directly is 10～100 μ m, the porosity is 50～90%.As long as have such characteristic, the liquid conservation rate (volume ratio) of medicament just can reach 100% or more than it, obtains volume swelling rate 200% or its above effect.In general, it is big to have a cubical expansivity of material in more little pore footpath.In addition, the material that the porosity is big, cubical expansivity also can increase certainly, but the porosity is when excessive, the mechanical strength undue weakening, and its shape will be destroyed.
In addition, as continuous multi-hole body, can also use polypropylene, polyethylene, polyvinyl alcohol etc. except polyurethane, depend on the kind of resin, the elongation complexity when keeping liquid is different.The most stretchy is the polyurethane continuous multi-hole body.Volume fully expanded when these liquid absorbent materials were initial, along with maintained pharmaceutical quantities reduces and slowly contraction.User can change from the volume contraction of swelling state according to continuous multi-hole body, and the decrement that container 1 side that constitutes from the coextrusion sheet material of CPP/EVOH/CPP is observed medicament changes.In addition, in the occasion of life-time service, also can keep original shape of continuous multi-hole body.
In the present embodiment, as the matrix shapes of containers 1 of filling medicament, used the container that the coextrusion sheet material vacuum mo(u)lding of CPP/EVOH/CPP or HDPE/EVOH/HDPE is made.At this moment, as long as the thickness of EVOH at 30 μ m or more than it, just can obtain enough gas barrier properties (gas impermeability) for the medicament of filling.In addition, for the moisture-proof that remedies EVOH and obtain enough chemical proofings, used sheet material with the coextrusion of the CPP of polyolefin or HDPE for medicament.Then, use the vacuum mo(u)lding method they can be processed into the container of arbitrary shape.The lid 40 that connects with container 1 also can use CPP or the HDPE identical with the container material, can obtain enough bond strengths after the heat-sealing.
In an embodiment, be used as first Breathable films of a controlling diaphragm of control medicament volatile quantity, used the composite laminate film of polypropylene (OPP) with polyethylene (LDPE), but operable stack membrane is not limited thereto among the present invention, can use polyethylene sheets (LDPE or HDPE), crystalline p p sheet (CPP or OPP), polyethylene terephthalate film (A-PET) separately, perhaps their compound films of making laminated construction be used.But, in the present invention, must make medicament control the delay that has in the film formed spatial portion to a certain degree by controlling diaphragm and secondary, therefore preferably the material of a controlling diaphragm is suitably selected, made the medicament release characteristics of a controlling diaphragm bigger than the medicament release characteristics of secondary controlling diaphragm.
All use allyl isosulfocyanate in an embodiment, but operable being not limited thereto among the present invention also can be used oil such as tea tree oil (Tea Three Oil) or Eucalyptus oil (Eucalyptus Oil).In addition, so long as just can obtain medicament antibiotic, mould proof effect, can be used as the medicament of slow released parts of volatile medicine 17 of the present invention with the volatile quantity of low concentration.
As can be seen from the above-described embodiment; be set to the sandwich of polyethylene or polypropylene and ethylene vinyl alcohol copolymer film by the formation of container; utilize the sufficient gas barrier property of ethylene vinyl alcohol copolymer film; the transit dose that can suppress liquid preparation; simultaneously; utilize polyethylene or polypropylene can protect ethylene vinyl alcohol copolymer film not to be subjected to humidity effect, will be suppressed to very small amount of degree from the medicament transit dose the body of container 1.The moisture sensitivity film 4 that is arranged on the lid 40 can change the slow release amount of controlling medicament according to the humidity of external environment condition.In addition, even slow released parts of volatile medicine 17 is exposed under the condition of high temperature in the logistics environment, owing to be with polyethylene or polypropylene each other heat fused constitute container 1 and lid 40, even superfluous medicament steam is full of the inside of container 1, also can prevent to cause lid 40 to be peeled off from container 1 because of the nip of medicament.
In addition, owing to be to make medicament control the delay that has in the film formed spatial portion to a certain degree, divide two stages to carry out film control and slow release medicine, so can stably supply with medicament with the low concentration of 20～200mg/ day by controlling diaphragm and secondary.
In addition, owing to liquid preparation and solid form height molecular material mixing are consolidated shapeization or tackifyization, the processing that can improve liquid preparation.After solid shapeization or tackifyization,, be filled in controlling diaphragm lining around it with the inorganic powder particle, even the medicament minimizing uneven phenomenon can not take place yet, can roughly similarly shrink.As a result, because medicament keeps vapor liquid equilibrium in a controlling diaphragm, can continue the concentration that keeps certain over a long time.
In addition, as the solid form height molecular material that is used to make solid shapeization of liquid preparation or tackifyization, use cellulosic ether, it can not produce issuable undesirable disagreeable foul smell when using other macromolecular material, can make the effectiveness last very long of volatile medicine.Because the weight average molecular weight of cellulosic ether is set in 100,000 or more than it, can bring into play the effect that makes solid shapeization of liquid preparation or tackifyization fully.Have again,, can also obtain to prevent the effect of medicament oxidation, can not need to use antioxidant or reduce its consumption by cellulosic ether is mixed with liquid preparation.
In addition, as the solid form height molecular material that is used to make solid shapeization of liquid preparation or tackifyization, use polyvinyl butyral resin, can not produce issuable undesirable disagreeable foul smell when using other macromolecular material, can make the effectiveness last very long of volatile medicine.Because the weight average molecular weight of polyvinyl butyral resin is 100,000 or more than it, the hydroxyl in the molecule is at 25 moles of % or below it, and the butyralization degree in the molecule is 70 moles of % or more than it, can bring into play the effect that makes solid shapeization of liquid preparation or tackifyization fully.Have again,, can also obtain to prevent the effect of medicament oxidation, can not need to use antioxidant or reduce its consumption by polyvinyl butyral resin is mixed with liquid preparation.
In addition, as the physical property of continuous multi-hole body, average pore directly is set at 10～100 μ m, the porosity is 50～90%, and the liquid conservation rate (volume ratio) of medicament can reach 100% or more than it, obtains sufficient volume swelling effect.
In addition, liquid absorbent material is the continuous multi-hole body of polyurethane, polypropylene, polyethylene or polyvinyl alcohol, thereby continuous multi-hole body can guarantee enough liquid-maintaining capacities, even configuration of components or direction change, also can not go wrong when practical.When life-time service, can keep original shape of continuous multi-hole body, simultaneously, along with the residual spray mixture variation and the contraction gradually of medicament, thereby user can be determined the residual spray mixture of medicament by visualization.
In addition, the burst size of medicament is 20～200mg/ day under 30 ℃, the environment of relative humidity 95%, though this kind with medicament is relevant, but because can be by feeling that with the people threshold value of abnormal smells from the patient compares following level and slowly discharge and obtains the medicament releasing effect of expecting, so can stay good impression to user.
In addition,, just can be suppressed at the invalid release of medicament under the low humidity condition under the environment of 30 ℃ of temperature and 30% relative humidity, can prolong the replacement cycle of medicament as long as the burst size of medicament is 10mg/ below day.
In addition, owing to, can suppress the invalid release of medicament in humidity lower season, and in humidity in higher season or environment, can stably continue slow release medicine with low concentration, thereby can continue to prevent its inner mold propagates for a long time for the indoor set of air conditioner.
Application on the industry
Use slow released parts of volatile medicine of the present invention, can prevent in the indoor set of air regulator Mold propagates. Can be widely used in and prevent because the humidity of seasonal variations or surrounding environment changes Cause mould, vegetative occasion, for example can be used for bathroom, dressing cubicle, geta case, food storage Zang Ku, storehouse, ground storage etc., the humidification that can also be used in addition building air-conditioning with path and Ventilation is with path etc.
Claims (20)
1. medicament slow released parts, it is characterized in that, the lid that these parts have the medicament that comprises chemical substance, the package body that surrounds this medicament, hold the container of this package body and seal this container, described container is to constitute by with polyethylene film or polypropylene screen interlayer the film formed sheet material of polymer of ethylene-vinyl alcohol combined polymerization being arranged; Described package body is the stack membrane that is selected from polyethylene film, polypropylene screen or polyethylene terephthalate film; Described lid is to be made of polyethylene film, polypropylene screen or their stack membrane and the moisture sensitivity film that forms on this film; Described moisture sensitivity film is to be made of artificial silk/paper pulp non-woven fabrics and the adhesive film that forms on this non-woven fabrics.
2. medicament slow released parts according to claim 1 is characterized in that described container has the matrix shape, and the internal volume of the described package body of interior volume specific ratio of described container is big.
3. medicament slow released parts according to claim 1 is characterized in that, has the spatial portion for the steam delay of the medicament that sees through package body between described package body and lid.
4. medicament slow released parts according to claim 1 is characterized in that, the described moisture sensitivity film medicament steam that it sees through when humidity is high more is many more.
5. medicament slow released parts according to claim 1 is characterized in that, the film of described lid engages with the polyethylene film of said vesse or polypropylene screen heat fused.
6. medicament slow released parts according to claim 1 is characterized in that, described chemical substance is to be selected from allyl isosulfocyanate, tea tree oil, Eucalyptus oil.
7. medicament slow released parts according to claim 1, it is characterized in that, described medicament is that described medicament is contained in the above-mentioned package body with the state of solid shapeization or tackifyization with respect to the mixture of above-mentioned chemical substance with 2: 1～10: 1 the solid form height molecular material of weight ratio cooperation.
8. medicament slow released parts according to claim 1, it is characterized in that, described medicament is that above-mentioned chemical substance is mixed and the mixture of tackify with solid form height molecular material, and this mixture is contained in the above-mentioned package body under its state on every side that is covered with the inorganic powder particle.
9. medicament slow released parts according to claim 8 is characterized in that, described solid form height molecular material is a cellulosic ether.
10. medicament slow released parts according to claim 8 is characterized in that, described solid form height molecular material is weight average molecular weight 100,000 or its above cellulosic ether.
11. medicament slow released parts according to claim 8 is characterized in that, described solid form height molecular material is a polyvinyl butyral resin.
12. medicament slow released parts according to claim 8, it is characterized in that, described solid form height molecular material is that weight average molecular weight 100,000 or its are above, the hydroxyl in the molecule at 25 moles of % or the butyralization degree below it, in the molecule at 70 moles of % or the polyvinyl butyral resin more than it.
13. medicament slow released parts according to claim 8, it is characterized in that, also having average pore directly is that 10～100 μ m, the porosity are 50～90% continuous multi-hole body, and this porous body can absorb and keep above-mentioned chemical substance, and described package body holds this porous body.
14. medicament slow released parts according to claim 13 is characterized in that, the material of described continuous multi-hole body is the material that is selected from polyurethane, polypropylene, polyethylene and polyvinyl alcohol.
15. medicament slow released parts according to claim 1 is characterized in that, the burst size of described medicament is 20～200mg/ day under the environment of 30 ℃ and relative humidity 95%.
16. medicament slow released parts according to claim 1 is characterized in that, the burst size of described medicament is 10mg/ day or below it under the environment of 30 ℃ and relative humidity 30%.
17. medicament slow released parts according to claim 1 is characterized in that, the medicament burst size of the more above-mentioned lid of medicament burst size of described package body is big.
18. air conditioner, it is characterized in that, this air conditioner has indoor set, described indoor set has been equipped with heat exchanger at least and has been used for being blown out to indoor pressure fan with carrying out thermoregulator wind by heat exchanger, this indoor set also has near the heat exchanger of being positioned at, be configured in the medicament slow released parts of the upstream side of inhaled air, this medicament slow released parts has the medicament that contains chemical substance, surround the package body of this medicament, the container that holds this package body, and with the lid of this seal of vessel, described container is to constitute by with polyethylene film or polypropylene screen interlayer the film formed sheet material of polymer of ethylene-vinyl alcohol combined polymerization being arranged; Described package body is the stack membrane that is selected from polyethylene film, polypropylene screen or polyethylene terephthalate film; Described lid is to be made of polyethylene film, polypropylene screen or their stack membrane and the moisture sensitivity film that forms on this film; Described moisture sensitivity film is to be made of artificial silk/paper pulp non-woven fabrics and the adhesive film that forms on this non-woven fabrics.
19. air conditioner according to claim 18 is characterized in that, the film of described lid engages with the polyethylene film of said vesse or polypropylene screen heat fused.
20. air conditioner according to claim 18 is characterized in that, has the big medicament slow released parts of medicament burst size of the more above-mentioned lid of medicament burst size of described package body.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003007981A JP2004215942A (en) | 2003-01-16 | 2003-01-16 | Controlled release member for volatile chemical and air conditioner using the same |
| JP2003007981 | 2003-01-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1517127A CN1517127A (en) | 2004-08-04 |
| CN1241650C true CN1241650C (en) | 2006-02-15 |
Family
ID=32897916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200410000663XA Expired - Fee Related CN1241650C (en) | 2003-01-16 | 2004-01-15 | Volatile chemical slow-releasing unit and air conditioner using the unit |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2004215942A (en) |
| KR (1) | KR20040066033A (en) |
| CN (1) | CN1241650C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008052416A1 (en) * | 2006-10-17 | 2008-05-08 | Yuhua Wang | A bottle-type air freshener |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011126022A1 (en) * | 2010-04-08 | 2011-10-13 | 日産化学工業株式会社 | Composition forming heat-cured film having photo-alignment properties |
| KR101826360B1 (en) * | 2011-12-02 | 2018-02-06 | 엘지전자 주식회사 | air conditioner |
| CN104776535A (en) * | 2015-05-04 | 2015-07-15 | 吉首大学 | Temperature and humidity adjustment device applied to library |
| CN107421030B (en) * | 2017-07-21 | 2019-12-24 | 武汉大学 | Cooling system based on phase-change microcapsule liquid slurry cold storage device and operation method |
-
2003
- 2003-01-16 JP JP2003007981A patent/JP2004215942A/en active Pending
-
2004
- 2004-01-15 KR KR1020040002874A patent/KR20040066033A/en not_active Application Discontinuation
- 2004-01-15 CN CNB200410000663XA patent/CN1241650C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008052416A1 (en) * | 2006-10-17 | 2008-05-08 | Yuhua Wang | A bottle-type air freshener |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1517127A (en) | 2004-08-04 |
| JP2004215942A (en) | 2004-08-05 |
| KR20040066033A (en) | 2004-07-23 |
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