CN118679259A - 抑制LPA（Apo(a)）蛋白表达的组合物和方法 - Google Patents

抑制LPA（Apo(a)）蛋白表达的组合物和方法 Download PDF

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Publication number
CN118679259A
CN118679259A CN202380021107.1A CN202380021107A CN118679259A CN 118679259 A CN118679259 A CN 118679259A CN 202380021107 A CN202380021107 A CN 202380021107A CN 118679259 A CN118679259 A CN 118679259A
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lpa
subject
dsrna
dsrna agent
nucleotides
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Chinese (zh)
Inventor
舒东旭
邵鹏程
夏时伟
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Shanghai Bowang Pharmaceutical Co ltd
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Shanghai Bowang Pharmaceutical Co ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Heart & Thoracic Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202380021107.1A 2022-01-24 2023-01-23 抑制LPA（Apo(a)）蛋白表达的组合物和方法 Pending CN118679259A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2022/073415 2022-01-24
CN2022073415 2022-01-24
PCT/CN2023/073456 WO2023138689A1 (zh) 2022-01-24 2023-01-23 抑制LPA(Apo(a))蛋白表达的组合物和方法

Publications (1)

Publication Number Publication Date
CN118679259A true CN118679259A (zh) 2024-09-20

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CN202380021107.1A Pending CN118679259A (zh) 2022-01-24 2023-01-23 抑制LPA（Apo(a)）蛋白表达的组合物和方法

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Country Link
US (2) US20250297250A1 (https=)
EP (1) EP4471144A4 (https=)
JP (1) JP7833044B2 (https=)
KR (1) KR20240135657A (https=)
CN (1) CN118679259A (https=)
AU (1) AU2023210010A1 (https=)
CA (1) CA3248387A1 (https=)
CL (1) CL2024002168A1 (https=)
CO (1) CO2024009492A2 (https=)
DO (1) DOP2024000141A (https=)
IL (1) IL314060A (https=)
JO (1) JOP20240159A1 (https=)
MX (1) MX2024008989A (https=)
PE (1) PE20250779A1 (https=)
TW (1) TW202345865A (https=)
WO (1) WO2023138689A1 (https=)

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CN119506275A (zh) * 2023-08-22 2025-02-25 苏州炫景生物科技有限公司 抑制lpa基因表达的双链寡核苷酸及其应用
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CN120020252A (zh) * 2023-11-17 2025-05-20 纳肽得(青岛)生物医药有限公司 抑制LPA表达的siRNA及其用途
WO2025117709A2 (en) * 2023-11-29 2025-06-05 Sanegene Bio Usa Inc. Small interfering rna targeting lp(a) and uses thereof
TW202546233A (zh) * 2024-02-05 2025-12-01 美商靖因藥業（上海）有限公司 用於抑制ｌｐ（ａ）或ａｐｏｃ３之表現的多核酸分子、醫藥組合物及其用途
WO2025252159A1 (zh) * 2024-06-06 2025-12-11 大睿生物医药科技(上海)有限公司 调控LPA表达的dsRNA分子

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JP2025504863A (ja) 2025-02-19
EP4471144A4 (en) 2026-01-21
TW202345865A (zh) 2023-12-01
MX2024008989A (es) 2024-07-29
CA3248387A1 (en) 2025-07-09
CL2024002168A1 (es) 2025-01-10
JOP20240159A1 (ar) 2024-07-21
KR20240135657A (ko) 2024-09-11
PE20250779A1 (es) 2025-03-14
JP7833044B2 (ja) 2026-03-18
US20250297250A1 (en) 2025-09-25
EP4471144A1 (en) 2024-12-04
CO2024009492A2 (es) 2024-10-31
IL314060A (en) 2024-09-01
WO2023138689A1 (zh) 2023-07-27
DOP2024000141A (es) 2024-10-15
AU2023210010A1 (en) 2024-07-25
US20250257356A1 (en) 2025-08-14

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