AU2023210010A1 - Composition and method for inhibiting expression of protein lpa(apo(a)) - Google Patents

Composition and method for inhibiting expression of protein lpa(apo(a)) Download PDF

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Publication number
AU2023210010A1
AU2023210010A1 AU2023210010A AU2023210010A AU2023210010A1 AU 2023210010 A1 AU2023210010 A1 AU 2023210010A1 AU 2023210010 A AU2023210010 A AU 2023210010A AU 2023210010 A AU2023210010 A AU 2023210010A AU 2023210010 A1 AU2023210010 A1 AU 2023210010A1
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insdseq
insdqualifier
insdfeature
name
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Pengcheng Patrick Shao
Dongxu Shu
Shiwei Xia
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Shanghai Argo Biopharmaceutical Co Ltd
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Shanghai Argo Biopharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Molecular Biology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2023210010A 2022-01-24 2023-01-23 Composition and method for inhibiting expression of protein lpa(apo(a)) Pending AU2023210010A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2022/073415 2022-01-24
CN2022073415 2022-01-24
PCT/CN2023/073456 WO2023138689A1 (zh) 2022-01-24 2023-01-23 抑制LPA(Apo(a))蛋白表达的组合物和方法

Publications (1)

Publication Number Publication Date
AU2023210010A1 true AU2023210010A1 (en) 2024-07-25

Family

ID=87347910

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Application Number Title Priority Date Filing Date
AU2023210010A Pending AU2023210010A1 (en) 2022-01-24 2023-01-23 Composition and method for inhibiting expression of protein lpa(apo(a))

Country Status (16)

Country Link
US (2) US20250297250A1 (https=)
EP (1) EP4471144A4 (https=)
JP (1) JP7833044B2 (https=)
KR (1) KR20240135657A (https=)
CN (1) CN118679259A (https=)
AU (1) AU2023210010A1 (https=)
CA (1) CA3248387A1 (https=)
CL (1) CL2024002168A1 (https=)
CO (1) CO2024009492A2 (https=)
DO (1) DOP2024000141A (https=)
IL (1) IL314060A (https=)
JO (1) JOP20240159A1 (https=)
MX (1) MX2024008989A (https=)
PE (1) PE20250779A1 (https=)
TW (1) TW202345865A (https=)
WO (1) WO2023138689A1 (https=)

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BR112021013807A2 (pt) 2019-01-18 2021-11-30 Astrazeneca Ab Inibidores de pcsk9 e seus métodos de uso
MX2021008661A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.
IL312811A (en) 2021-11-16 2024-07-01 Shanghai Argo Biopharmaceutical Co Ltd Composition and method for inhibiting angiotensinogen (agt) protein expression
CR20250257A (es) * 2022-12-02 2025-08-28 Shanghai Argo Biopharmaceutical Co Ltd Análogos de ácidos nucleicos bicíclicos abásicos y compuestos oligoméricos preparados a partir de estos
CN119506275A (zh) * 2023-08-22 2025-02-25 苏州炫景生物科技有限公司 抑制lpa基因表达的双链寡核苷酸及其应用
WO2025064821A2 (en) * 2023-09-21 2025-03-27 Ionis Pharmaceuticals, Inc. Compounds and methods for inhibiting lpa
WO2025082059A1 (zh) * 2023-10-16 2025-04-24 润佳(上海)医药技术有限公司 经修饰的dsRNA、双链RNAi剂及其用途
WO2025087442A1 (zh) * 2023-10-27 2025-05-01 北京安龙生物医药有限公司 靶向脂蛋白a的寡核苷酸及其用途
CN120020252A (zh) * 2023-11-17 2025-05-20 纳肽得(青岛)生物医药有限公司 抑制LPA表达的siRNA及其用途
WO2025117709A2 (en) * 2023-11-29 2025-06-05 Sanegene Bio Usa Inc. Small interfering rna targeting lp(a) and uses thereof
TW202546233A (zh) * 2024-02-05 2025-12-01 美商靖因藥業（上海）有限公司 用於抑制ｌｐ（ａ）或ａｐｏｃ３之表現的多核酸分子、醫藥組合物及其用途
WO2025252159A1 (zh) * 2024-06-06 2025-12-11 大睿生物医药科技(上海)有限公司 调控LPA表达的dsRNA分子

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Publication number Publication date
JP2025504863A (ja) 2025-02-19
EP4471144A4 (en) 2026-01-21
TW202345865A (zh) 2023-12-01
MX2024008989A (es) 2024-07-29
CA3248387A1 (en) 2025-07-09
CL2024002168A1 (es) 2025-01-10
JOP20240159A1 (ar) 2024-07-21
KR20240135657A (ko) 2024-09-11
CN118679259A (zh) 2024-09-20
PE20250779A1 (es) 2025-03-14
JP7833044B2 (ja) 2026-03-18
US20250297250A1 (en) 2025-09-25
EP4471144A1 (en) 2024-12-04
CO2024009492A2 (es) 2024-10-31
IL314060A (en) 2024-09-01
WO2023138689A1 (zh) 2023-07-27
DOP2024000141A (es) 2024-10-15
US20250257356A1 (en) 2025-08-14

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