CN118649138A - 连续制造有效成分颗粒的方法 - Google Patents

连续制造有效成分颗粒的方法 Download PDF

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Publication number
CN118649138A
CN118649138A CN202410708653.9A CN202410708653A CN118649138A CN 118649138 A CN118649138 A CN 118649138A CN 202410708653 A CN202410708653 A CN 202410708653A CN 118649138 A CN118649138 A CN 118649138A
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CN
China
Prior art keywords
active ingredient
particles
process chamber
spray
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202410708653.9A
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English (en)
Chinese (zh)
Inventor
R·诺瓦克
N·波林杰
A·格拉维
M·雅各布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ed Advanced Drug Delivery Technology Co ltd
Original Assignee
Ed Advanced Drug Delivery Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ed Advanced Drug Delivery Technology Co ltd filed Critical Ed Advanced Drug Delivery Technology Co ltd
Publication of CN118649138A publication Critical patent/CN118649138A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CN202410708653.9A 2019-04-11 2020-04-09 连续制造有效成分颗粒的方法 Pending CN118649138A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP19168685.6 2019-04-11
EP19168685.6A EP3721871A1 (de) 2019-04-11 2019-04-11 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
PCT/EP2020/060278 WO2020208202A1 (de) 2019-04-11 2020-04-09 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
CN202080042899.7A CN114302711A (zh) 2019-04-11 2020-04-09 连续制造有效成分颗粒的方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202080042899.7A Division CN114302711A (zh) 2019-04-11 2020-04-09 连续制造有效成分颗粒的方法

Publications (1)

Publication Number Publication Date
CN118649138A true CN118649138A (zh) 2024-09-17

Family

ID=66105207

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202410708653.9A Pending CN118649138A (zh) 2019-04-11 2020-04-09 连续制造有效成分颗粒的方法
CN202080042899.7A Pending CN114302711A (zh) 2019-04-11 2020-04-09 连续制造有效成分颗粒的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202080042899.7A Pending CN114302711A (zh) 2019-04-11 2020-04-09 连续制造有效成分颗粒的方法

Country Status (13)

Country Link
US (1) US12551443B2 (https=)
EP (2) EP3721871A1 (https=)
JP (1) JP7602483B2 (https=)
CN (2) CN118649138A (https=)
AU (1) AU2020271280B2 (https=)
BR (1) BR112021020282A2 (https=)
CA (1) CA3144742A1 (https=)
DK (1) DK3952844T3 (https=)
ES (1) ES3053040T3 (https=)
IL (1) IL287121B1 (https=)
PL (1) PL3952844T3 (https=)
PT (1) PT3952844T (https=)
WO (1) WO2020208202A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102024107710A1 (de) * 2024-03-18 2025-09-18 Glatt Gesellschaft Mit Beschränkter Haftung Verfahren zur Herstellung von Tabletten
DE102024107712A1 (de) * 2024-03-18 2025-09-18 Glatt Gesellschaft Mit Beschränkter Haftung Vorrichtung zur Herstellung von Tabletten

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0739201T3 (da) 1994-01-14 2000-05-01 Ethypharm Lab Prod Ethiques Mikrogranuler af 5-nitro-imidazolderivater
DE19514187C1 (de) * 1995-04-21 1996-05-15 Degussa Verfahren und Vorrichtung zur Herstellung von Granulaten durch Wirbelschicht-Sprühgranulation
PT1117729E (pt) * 1998-07-21 2004-01-30 Vantico Ag Granulados escoaveis
US6117451A (en) 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
DE10004939C1 (de) 2000-02-05 2001-08-23 Lothar Moerl Steuerbare Gasanströmeinrichtung für Strahlschichtapparate
NZ526720A (en) * 2000-12-28 2007-11-30 Altus Pharmaceuticals Inc Crystallisation of whole antibodies or fragments thereof, on a large scale and a process allowing an alternative route for delivery of therapeutic antibodies
US6667054B2 (en) 2001-12-05 2003-12-23 Bernard Charles Sherman Metformin hydrochloride tablets
KR100592512B1 (ko) * 2002-11-22 2006-07-03 서울약품공업(주) 탐술로신 또는 약제학적으로 허용되는 이의 염을활성성분으로 하는 서방성 배뇨장애 치료제
DE10322062A1 (de) 2003-05-15 2004-12-02 Glatt Ingenieurtechnik Gmbh Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates
ES2374191T3 (es) 2003-06-11 2012-02-14 Glatt Ingenieurtechnik Gmbh Procedimiento de preparación de granulados de enzimas y granulados de enzimas así obtenidos.
DE102005037630A1 (de) * 2005-08-09 2007-02-15 Glatt Gmbh Verfahren zur Herstellung von Teilchen aus pharmazeutischen Substanzen, Teilchen aus pharmazeutischen Substanzen sowie deren Verwendung
DE102007012105A1 (de) * 2007-03-13 2008-09-18 Add Advanced Drug Delivery Technologies Ltd. Pellets enthaltend pharmazeutische Substanz, Verfahren zu deren Herstellung und deren Verwendung
WO2010066385A1 (de) 2008-12-08 2010-06-17 Ratiopharm Gmbh Kompaktiertes moxifloxacin
WO2010106555A2 (en) 2009-03-17 2010-09-23 Shantilal, Doshi, Bimalkumar Directly compressible pre-granulated cellulose ether polymer and process for preparing the same
JP5922310B2 (ja) * 2013-07-25 2016-05-24 株式会社三和化学研究所 医薬製剤
WO2018034627A1 (en) * 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet
EP3721870A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats

Also Published As

Publication number Publication date
IL287121A (en) 2022-01-01
JP2022528783A (ja) 2022-06-15
DK3952844T3 (da) 2025-11-17
WO2020208202A1 (de) 2020-10-15
AU2020271280B2 (en) 2025-07-24
IL287121B1 (en) 2026-01-01
JP7602483B2 (ja) 2024-12-18
ES3053040T3 (en) 2026-01-16
US20220280432A1 (en) 2022-09-08
PT3952844T (pt) 2025-11-21
EP3952844B1 (de) 2025-08-27
CN114302711A (zh) 2022-04-08
CA3144742A1 (en) 2020-10-15
PL3952844T3 (pl) 2026-01-19
EP3952844A1 (de) 2022-02-16
BR112021020282A2 (pt) 2021-12-14
US12551443B2 (en) 2026-02-17
EP3721871A1 (de) 2020-10-14
AU2020271280A1 (en) 2021-12-09

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