CN118591379A - 用于治疗或预防t细胞相关疾病的药物组合物 - Google Patents

用于治疗或预防t细胞相关疾病的药物组合物 Download PDF

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Publication number
CN118591379A
CN118591379A CN202280077889.6A CN202280077889A CN118591379A CN 118591379 A CN118591379 A CN 118591379A CN 202280077889 A CN202280077889 A CN 202280077889A CN 118591379 A CN118591379 A CN 118591379A
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cells
positive
pharmaceutical composition
cell
inducible regulatory
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Chinese (zh)
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三上统久
坂口志文
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Reg Cell Co ltd
University of Osaka NUC
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Reg Cell Co ltd
Osaka University NUC
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CN202280077889.6A 2021-11-24 2022-11-22 用于治疗或预防t细胞相关疾病的药物组合物 Pending CN118591379A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021190125 2021-11-24
JP2021-190125 2021-11-24
PCT/JP2022/043221 WO2023095802A1 (ja) 2021-11-24 2022-11-22 Ｔ細胞関連疾患を治療または予防するための医薬組成物

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CN118591379A true CN118591379A (zh) 2024-09-03

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CN202280077889.6A Pending CN118591379A (zh) 2021-11-24 2022-11-22 用于治疗或预防t细胞相关疾病的药物组合物

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US (1) US20250352578A1 (https=)
EP (1) EP4438048A4 (https=)
JP (1) JPWO2023095802A1 (https=)
KR (1) KR20240130083A (https=)
CN (1) CN118591379A (https=)
CA (1) CA3238860A1 (https=)
MX (1) MX2024006370A (https=)
TW (1) TW202334397A (https=)
WO (1) WO2023095802A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118591619A (zh) * 2021-11-24 2024-09-03 雷格细胞股份有限公司 人诱导性调节性t细胞及其制作方法
WO2024204553A1 (ja) * 2023-03-29 2024-10-03 レグセル株式会社 ヒト誘導性制御性ｔ細胞およびその作製方法、およびｔ細胞関連疾患を治療または予防するための医薬組成物
JP2025064863A (ja) * 2023-10-06 2025-04-17 株式会社マイオリッジ Ｔ細胞の培養方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101883844A (zh) * 2007-10-12 2010-11-10 分子医学马克斯德尔布吕克中心 快速分离人Foxp3+Treg细胞的方法和试剂盒
US8598344B2 (en) 2009-11-30 2013-12-03 Senex Biotechnology CDKI pathway inhibitors and uses thereof
WO2013001310A1 (en) 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
US20140309224A1 (en) 2011-09-13 2014-10-16 Roninson Igor B TREATMENT OF DISEASES OR DISORDERS CAUSED BY INDUCED NFkB TRANSCRIPTIONAL ACTIVITY
UA117342C2 (uk) 2012-02-02 2018-07-25 Сенекс Біотекнолоджи Інк. Селективні інгібітори cdk8/cdk19 та їх застосування як протиметастатичних та хіміопрофілактичних засобів у способах лікування раку
EP2888232A1 (en) 2012-08-23 2015-07-01 F. Hoffmann-La Roche AG Novel phenyl-pyridine/pyrazine amides for the treatment of cancer
ES2698960T3 (es) 2012-10-08 2019-02-06 Merck Patent Gmbh Compuestos de 2-aminopiridina
GB201220157D0 (en) 2012-11-08 2012-12-26 Selvita Sa Substitute tricyclic benzimidazoles as kinase inhibitors
JP2016501251A (ja) 2012-12-10 2016-01-18 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト がんの治療のための新規二環フェニル−ピリジン／ピラジン
WO2014106606A1 (en) 2013-01-05 2014-07-10 F. Hoffmann-La Roche Ag Nove phenyl/pyridine series substitued by hydroxyethylamino for the treatment of cancer
WO2014123900A1 (en) 2013-02-05 2014-08-14 Sirenas Marine Discovery Anti-cancer and anti-hiv compounds
WO2014154723A1 (en) 2013-03-29 2014-10-02 F. Hoffmann-La Roche Ag Novel pyrrole derivatives for the treatment of cancer
WO2014194245A2 (en) 2013-05-31 2014-12-04 Nimbus Iris, Inc. Cdk8 inhibitors and uses thereof
TW201605857A (zh) 2013-10-03 2016-02-16 赫孚孟拉羅股份公司 Ｃｄｋ８之醫療性抑制劑及其用途
SG11201605178WA (en) 2013-12-24 2016-07-28 Harvard College Cortistatin analogues and syntheses and uses thereof
JP6434989B2 (ja) 2014-03-27 2018-12-05 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ピリジルピペリジン
EP3205645B1 (en) 2014-04-18 2019-10-23 Takeda Pharmaceutical Company Limited Heterocyclic compound
JP6521387B2 (ja) 2014-04-18 2019-05-29 武田薬品工業株式会社 縮合複素環化合物
WO2016009076A1 (en) 2014-07-17 2016-01-21 Merck Patent Gmbh Novel naphthryidines and isoquinolines and their use as cdk8/19 inhibitors
CA3051469A1 (en) * 2017-01-27 2018-08-02 Abraham J And Phyllis Katz Cord Blood Foundation T cells derived from umbilical cord blood
US11578067B2 (en) 2017-01-30 2023-02-14 Kyoto University Compound, and method for producing regulatory T cells
US20210238551A1 (en) * 2018-08-22 2021-08-05 Osaka University Method for Generating Regulatory T Cells
EP3880213A4 (en) * 2018-11-13 2022-11-23 Abraham J and Phyllis Katz Cord Blood Foundation T CELLS WITH IMPROVED MITOCHONDRIAL FUNCTION
US20220018835A1 (en) * 2018-12-07 2022-01-20 INSERM (Institut National de la Santé et de la Recherche Médicale Use of cd26 and cd39 as new phenotypic markers for assessing maturation of foxp3+ t cells and uses thereof for diagnostic purposes
KR20210149201A (ko) * 2019-04-30 2021-12-08 더 리전트 오브 더 유니버시티 오브 캘리포니아 인간 조절 t 세포의 비드-무함유 생체외 확장
US20210373951A1 (en) 2020-05-28 2021-12-02 Samsung Electronics Co., Ltd. Systems and methods for composable coherent devices
CN118591619A (zh) * 2021-11-24 2024-09-03 雷格细胞股份有限公司 人诱导性调节性t细胞及其制作方法
EP4532697A2 (en) * 2022-06-03 2025-04-09 Beam Therapeutics Inc. Modified regulatory t cells and methods of using the same
EP4596684A1 (en) * 2022-09-26 2025-08-06 Regcell Co., Ltd. Induced regulatory t cells containing chimeric antigen receptor (car)

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KR20240130083A (ko) 2024-08-28
EP4438048A1 (en) 2024-10-02
JPWO2023095802A1 (https=) 2023-06-01
CA3238860A1 (en) 2023-06-01
US20250352578A1 (en) 2025-11-20
EP4438048A4 (en) 2025-10-22
WO2023095802A1 (ja) 2023-06-01
MX2024006370A (es) 2024-08-19
TW202334397A (zh) 2023-09-01

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