CN118451058A - Rxfp1激动剂 - Google Patents

Rxfp1激动剂 Download PDF

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Publication number
CN118451058A
CN118451058A CN202280084766.5A CN202280084766A CN118451058A CN 118451058 A CN118451058 A CN 118451058A CN 202280084766 A CN202280084766 A CN 202280084766A CN 118451058 A CN118451058 A CN 118451058A
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China
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substituted
alkyl
halo
cycloalkyl
substituents
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CN202280084766.5A
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Chinese (zh)
Inventor
S·A·肖
A·J·克拉克
T·J·弗仁德斯
A·马瑟
M·C·迈尔斯
李建庆
K·B·帕比斯蒂
苏顺
G·O·托拉
B·P·沃基特
N·R·沃茨
D·J·P·平托
L·帕索诺里
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of CN118451058A publication Critical patent/CN118451058A/zh
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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