CN118420762A - 包含cd4结合部分的免疫细胞受体 - Google Patents

包含cd4结合部分的免疫细胞受体 Download PDF

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Publication number
CN118420762A
CN118420762A CN202410461081.9A CN202410461081A CN118420762A CN 118420762 A CN118420762 A CN 118420762A CN 202410461081 A CN202410461081 A CN 202410461081A CN 118420762 A CN118420762 A CN 118420762A
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immune cell
seq
amino acid
acid sequence
domain
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Chinese (zh)
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曾明
陈丽丽
刘勋
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
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CN202410461081.9A 2019-05-16 2020-05-15 包含cd4结合部分的免疫细胞受体 Withdrawn CN118420762A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNPCT/CN2019/087260 2019-05-16
CN2019087260 2019-05-16
CN202080036396.9A CN113825766A (zh) 2019-05-16 2020-05-15 包含cd4结合部分的免疫细胞受体
PCT/CN2020/090600 WO2020228824A1 (en) 2019-05-16 2020-05-15 Immune cell receptors comprsing cd4 binding moieties

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CN118420762A true CN118420762A (zh) 2024-08-02

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CN202410461081.9A Withdrawn CN118420762A (zh) 2019-05-16 2020-05-15 包含cd4结合部分的免疫细胞受体
CN202080036396.9A Pending CN113825766A (zh) 2019-05-16 2020-05-15 包含cd4结合部分的免疫细胞受体
CN202080036374.2A Pending CN113840912A (zh) 2019-05-16 2020-05-15 包含识别分子的工程化免疫细胞

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CN202080036374.2A Pending CN113840912A (zh) 2019-05-16 2020-05-15 包含识别分子的工程化免疫细胞

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US (2) US20220265711A1 (https=)
EP (2) EP3969572A4 (https=)
JP (2) JP2022533621A (https=)
KR (2) KR20220010722A (https=)
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202110873A (zh) 2019-04-30 2021-03-16 美商聖堤生物科技股份有限公司 嵌合受體及其使用方法
EP4291573A4 (en) * 2021-02-09 2025-01-29 Nanjing Legend Biotech Co., Ltd. Engineered cells and uses thereof
GB202105684D0 (en) * 2021-04-21 2021-06-02 Imperial College Innovations Ltd Chimeric antigen receptor (CAR)-T cells
EP4381081A1 (en) 2021-08-04 2024-06-12 Sana Biotechnology, Inc. Use of cd4-targeted viral vectors
WO2023114949A1 (en) 2021-12-16 2023-06-22 Sana Biotechnology, Inc. Methods and systems of particle production
EP4463135A2 (en) 2022-01-10 2024-11-20 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023150647A1 (en) 2022-02-02 2023-08-10 Sana Biotechnology, Inc. Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
WO2024026377A1 (en) 2022-07-27 2024-02-01 Sana Biotechnology, Inc. Methods of transduction using a viral vector and inhibitors of antiviral restriction factors
US20260055146A1 (en) 2022-08-24 2026-02-26 Sana Biotechnology, Inc. Delivery of heterologous proteins
CN116063501A (zh) * 2022-08-29 2023-05-05 华道(上海)生物医药有限公司 一种抗cd4抗体及其用途
WO2024064838A1 (en) 2022-09-21 2024-03-28 Sana Biotechnology, Inc. Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
CN115819622A (zh) * 2022-09-26 2023-03-21 湖南省人民医院(湖南师范大学附属第一医院) 针对b系白血病或淋巴瘤的双靶点car结构及药物组合物
WO2024119157A1 (en) 2022-12-02 2024-06-06 Sana Biotechnology, Inc. Lipid particles with cofusogens and methods of producing and using the same
WO2024220597A2 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Digital droplet based assay for detecting replication competent lentiviral vector
CN116836284A (zh) * 2023-04-21 2023-10-03 浙江正熙生物技术有限公司 一种抗人cd4抗体及其制备方法和应用
EP4716750A1 (en) 2023-05-23 2026-04-01 Sana Biotechnology, Inc. Tandem fusogens and related lipid particles
CN121941762A (zh) * 2023-09-25 2026-04-28 詹森生物科技公司 用于产生工程化细胞和/或可工程化细胞的组合物和方法
WO2025184529A1 (en) 2024-03-01 2025-09-04 Sana Biotechnology, Inc. Viral particles with fusogen display and related compositions and methods
WO2026032970A1 (en) 2024-08-07 2026-02-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Cd4-specific chimeric antigen receptor and methods and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006281803B9 (en) * 2005-08-18 2013-05-30 Genmab A/S Therapy with CD4 binding peptides and radiation
CA2861491C (en) * 2012-02-13 2020-08-25 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
RU2658485C2 (ru) * 2012-10-24 2018-06-21 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Химерные антигенные рецепторы м971
JP6839074B2 (ja) * 2014-09-17 2021-03-03 ノバルティス アーゲー 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング
PL3560953T3 (pl) * 2014-12-24 2024-05-13 Autolus Limited Komórka
JP7237449B2 (ja) * 2015-02-27 2023-03-13 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法
JP6961490B2 (ja) * 2015-04-08 2021-11-05 ノバルティス アーゲー Ｃｄ２０療法、ｃｄ２２療法、およびｃｄ１９キメラ抗原受容体（ｃａｒ）発現細胞との併用療法
AU2016274989A1 (en) * 2015-06-12 2017-11-02 Immunomedics, Inc. Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs
GB201601077D0 (en) * 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
WO2017177175A1 (en) * 2016-04-07 2017-10-12 The George Washington University Methods and compositions targeting retroviral latency
KR20190071677A (ko) * 2016-08-13 2019-06-24 유나이티드 바이오파마, 인크. Haart 안정화된 환자에서 cd4에 대한 항체에 의한 hiv 감염의 치료 및 지속적 바이러스 완화
ES2981703T3 (es) * 2016-09-02 2024-10-10 Lentigen Tech Inc Composiciones y métodos para tratar cáncer con DuoCars
CN107964549B (zh) * 2016-10-20 2020-12-08 上海恒润达生生物科技有限公司 靶向cd22的嵌合抗原受体及其用途
WO2019020733A1 (en) * 2017-07-26 2019-01-31 Cellectis METHODS OF IMMUNE CELL SELECTION OF THE ANTIGEN-DEPENDENT CHIMERIC ANTIGENIC RECEPTOR (CAR)
AU2019302603A1 (en) * 2018-07-13 2021-01-14 Nanjing Legend Biotech Co., Ltd. Co-receptor systems for treating infectious diseases

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