CN118369581A - 用于干燥与聚合物染料缀合的抗体的新的制剂 - Google Patents

用于干燥与聚合物染料缀合的抗体的新的制剂 Download PDF

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Publication number
CN118369581A
CN118369581A CN202180104842.XA CN202180104842A CN118369581A CN 118369581 A CN118369581 A CN 118369581A CN 202180104842 A CN202180104842 A CN 202180104842A CN 118369581 A CN118369581 A CN 118369581A
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China
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monomer
optionally substituted
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Pending
Application number
CN202180104842.XA
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English (en)
Chinese (zh)
Inventor
阿迪蒂亚·亚拉雷
拉杰什·文卡特什
苏梅特·舒拉
梅于尔·吉夫拉亚尼
奈纳·阿罗拉
戈皮纳德·亚卡
希瓦·兰吉尼·斯里尼瓦桑
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Beckman Coulter Inc
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Coulter International Corp
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Application filed by Coulter International Corp filed Critical Coulter International Corp
Publication of CN118369581A publication Critical patent/CN118369581A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/006—Preparation of organic pigments
    • C09B67/0066—Aqueous dispersions of pigments containing only dispersing agents
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C09K11/025—Use of particular materials as binders, particle coatings or suspension media therefor non-luminescent particle coatings or suspension media
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/14—Macromolecular compounds
    • C09K2211/1408—Carbocyclic compounds
    • C09K2211/1416—Condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
CN202180104842.XA 2021-11-12 2021-11-12 用于干燥与聚合物染料缀合的抗体的新的制剂 Pending CN118369581A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2021/059251 WO2023086103A1 (en) 2021-11-12 2021-11-12 Novel formulation for drying of polymer dye conjugated antibodies

Publications (1)

Publication Number Publication Date
CN118369581A true CN118369581A (zh) 2024-07-19

Family

ID=78844790

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180104842.XA Pending CN118369581A (zh) 2021-11-12 2021-11-12 用于干燥与聚合物染料缀合的抗体的新的制剂

Country Status (9)

Country Link
US (1) US20250052742A1 (https=)
EP (1) EP4430397A1 (https=)
JP (1) JP2024544923A (https=)
CN (1) CN118369581A (https=)
AU (1) AU2021473587A1 (https=)
CA (1) CA3237877A1 (https=)
MX (1) MX2024005772A (https=)
WO (1) WO2023086103A1 (https=)
ZA (1) ZA202403640B (https=)

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723218A (en) 1990-04-16 1998-03-03 Molecular Probes, Inc. Dipyrrometheneboron difluoride labeled flourescent microparticles
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5187288A (en) 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
US5576424A (en) 1991-08-23 1996-11-19 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
CA2119126C (en) 1991-09-16 1996-09-03 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes
US5658751A (en) 1993-04-13 1997-08-19 Molecular Probes, Inc. Substituted unsymmetrical cyanine dyes with selected permeability
US5656449A (en) 1995-03-06 1997-08-12 Molecular Probes, Inc. Neutral unsymmetrical cyanine dyes
US5798276A (en) 1995-06-07 1998-08-25 Molecular Probes, Inc. Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
US6596522B2 (en) 1997-05-08 2003-07-22 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US6004536A (en) 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty
US6162931A (en) 1996-04-12 2000-12-19 Molecular Probes, Inc. Fluorinated xanthene derivatives
US6005113A (en) 1996-05-15 1999-12-21 Molecular Probes, Inc. Long wavelength dyes for infrared tracing
US5846737A (en) 1996-07-26 1998-12-08 Molecular Probes, Inc. Conjugates of sulforhodamine fluorophores with enhanced fluorescence
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
JP2002528723A (ja) 1998-10-27 2002-09-03 モレキュラー・プロウブズ・インコーポレーテッド 遷移金属錯体を含有する発光タンパク質染色剤
WO2000064988A1 (en) 1999-04-23 2000-11-02 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
US6579718B1 (en) 2000-08-04 2003-06-17 Molecular Probes, Inc. Carbazolylvinyl dye protein stains
EP1311487B1 (en) 2000-08-04 2008-11-26 Molecular Probes, Inc. Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
CA2423806C (en) 2000-09-29 2009-12-22 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
US6972326B2 (en) 2001-12-03 2005-12-06 Molecular Probes, Inc. Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes
CN1675377B (zh) 2002-06-20 2012-10-03 加州大学评议会 利用获取光的多发色团检测和分析多核苷酸的方法和组合物
EP2607431B1 (en) 2003-12-05 2016-08-24 Life Technologies Corporation Cyanine dye compounds
US8158444B2 (en) 2006-10-06 2012-04-17 Sirigen, Inc. Fluorescent methods and materials for directed biomarker signal amplification
CA2786713C (en) 2010-01-19 2018-03-06 Sirigen Group Limited Novel reagents for directed biomarker signal amplification
DK2934582T3 (da) * 2012-12-21 2020-02-24 Ichnos Sciences SA Anti-her2-antistofformulering
US20140302516A1 (en) * 2013-03-14 2014-10-09 University Of Washington Through Its Center For Commercialization Polymer dot compositions and related methods
SG11201703870UA (en) * 2014-11-18 2017-06-29 Ascendis Pharma Endocrinology Div As Novel polymeric hgh prodrugs
AU2017250778B2 (en) 2016-04-15 2021-09-23 Beckman Coulter, Inc. Photoactive macromolecules and uses thereof
WO2017222998A1 (en) * 2016-06-20 2017-12-28 Beckman Coulter, Inc. Dry-down processes for dye-conjugated reagents
CN110337331B (zh) * 2017-02-08 2022-04-26 贝克顿·迪金森公司 干染料试剂装置以及制造和使用所述干染料试剂装置的方法
US11584825B2 (en) 2018-12-14 2023-02-21 Beckman Coulter, Inc. Polymer dye modification and applications
CN113874522B (zh) * 2019-05-29 2025-07-22 藤仓化成株式会社 固相附着用组合物、利用该组合物的固相载体以及该固相载体的生产方法和使用方法
CN111394346A (zh) * 2020-03-20 2020-07-10 基蛋生物科技股份有限公司 Rna核酸释放剂和pcr扩增试剂的冻干微球制备方法及其应用

Also Published As

Publication number Publication date
JP2024544923A (ja) 2024-12-05
EP4430397A1 (en) 2024-09-18
CA3237877A1 (en) 2023-05-19
WO2023086103A1 (en) 2023-05-19
MX2024005772A (es) 2024-07-22
AU2021473587A1 (en) 2024-06-20
ZA202403640B (en) 2025-02-26
US20250052742A1 (en) 2025-02-13

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