CN118304508A - Blood purification pipeline, method for connecting blood purification pipeline and pipeline fixing device - Google Patents
Blood purification pipeline, method for connecting blood purification pipeline and pipeline fixing deviceInfo
- Publication number
- CN118304508A CN118304508A CN202410282512.5A CN202410282512A CN118304508A CN 118304508 A CN118304508 A CN 118304508A CN 202410282512 A CN202410282512 A CN 202410282512A CN 118304508 A CN118304508 A CN 118304508A
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- line
- joint
- blood purification
- venous
- blood
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Abstract
The application provides a blood purifying pipeline, a method for connecting the blood purifying pipeline and a pipeline fixing device. The blood purification circuit includes: a common line assembly comprising an arterial line, a venous line, a fluid replacement line, and a filtrate line, the common line assembly adapted for use in any one of a plurality of treatment modes; a target auxiliary line assembly for connecting the common line assembly and a target filter such that the blood purification line is a continuous line suitable for a target treatment mode, the target filter comprising one or more filters; the arterial line is provided with first input joint and first output joint, first input joint is connected with the arterial puncture needle on one's body of patient, first output joint with the target filter is connected, venous line is provided with second input joint and second output joint, the second input joint with the target filter is connected, the second output joint with the venous puncture needle on one's body of patient is connected, the fluid replacement line is provided with third input joint and third output joint, third input joint is connected with the fluid replacement container, the filtrate line is provided with fourth input joint and fourth output joint, fourth output joint is connected with the waste liquid container. The embodiment of the application is beneficial to simplifying the installation steps, reducing the installation and switching time and reducing the take-over errors.
Description
Technical Field
The application relates to the technical field of blood purification treatment, in particular to a blood purification pipeline, a method for connecting the blood purification pipeline and a pipeline fixing device.
Background
Continuous blood purification treatment is a treatment mode in which blood is led out of the body, harmful substances and moisture in the blood are removed through a purification device, and the purified blood is conveyed back into the body. The pipelines used in the blood purification process provided by manufacturers of continuous blood purification treatment equipment for hospitals are generally applicable to the traditional treatment mode, namely, the requirements of the traditional treatment mode are met: treatment of Slow Continuous Ultrafiltration (SCUF), continuous intravenous hemofiltration (CVVH), continuous intravenous hemodiafiltration (CVVHDF), continuous intravenous hemodialysis (CVVHD). When other combined treatment modes (such as double filtration and plasma exchange, plasma adsorption and plasma dialysis and filtration) are needed in hospitals, blood purification pipelines corresponding to each treatment mode are needed to be customized and purchased independently to consumable manufacturers.
In the face of multiple treatment modes, hospitals need to be provided with a plurality of corresponding pipelines, so that the cost is increased. The various treatment modes require different blood purification pipelines, so that the time for selecting and installing the pipelines in the treatment process is increased, and the risk of wrong connection of the pipelines is increased.
Disclosure of Invention
The application provides a blood purifying pipeline, a method for connecting the blood purifying pipeline and a pipeline fixing device. Various aspects of embodiments of the application are described below.
In a first aspect, there is provided a blood purification circuit comprising: a common line assembly comprising an arterial line, a venous line, a fluid replacement line, and a filtrate line, the common line assembly adapted for use in any one of a plurality of treatment modes; a target auxiliary line assembly for connecting the common line assembly and a target filter such that the blood purification line is a continuous line suitable for a target treatment mode, the target filter comprising one or more filters; the arterial line is provided with first input joint and first output joint, first input joint is connected with the arterial puncture needle on one's body of patient, first output joint with the target filter is connected, venous line is provided with second input joint and second output joint, the second input joint with the target filter is connected, the second output joint with the venous puncture needle on one's body of patient is connected, the fluid replacement line is provided with third input joint and third output joint, third input joint is connected with the fluid replacement container, the filtrate line is provided with fourth input joint and fourth output joint, fourth output joint is connected with the waste liquid container.
In one possible embodiment, the target auxiliary line assembly is composed of one or more auxiliary lines of the same or different type.
In one possible embodiment, any auxiliary line of the one or more auxiliary lines is composed of at least some of the following elements, the joints of the elements constituting any auxiliary line being matched: female joint, male joint, dialysis joint, T-shaped three-way joint, Y-shaped three-way joint, body, pressure measuring branch pipe, fluid supplementing branch pipe and liquid pump pipe clamp, pump pipe and plasma pot.
In one possible embodiment, the first output connector and the second input connector are dialysis connectors, and the third output connector and the fourth input connector are male connectors.
In one possible embodiment, the one or more filters comprise part or all of a hemofilter, a hemodialyzer, a plasma separator, a perfusion, an adsorber.
In one possible embodiment, the plurality of treatment modes are some or all of the following treatment modes: slow continuous ultrafiltration SCUF, continuous intravenous-venous hemofiltration CVVH, continuous intravenous-venous hemodiafiltration CVVHDF, continuous intravenous-venous hemodialysis CVVHD, double filtration plasmapheresis DFPP, plasmafiltration PA, plasmafiltration PDF, double plasma molecular adsorption system DPMAS, paired plasmafiltration adsorption CPFA, hemoperfusion HP, repeated albumin dialysis RAD, single albumin pass dialysis SPAD, molecular adsorption recirculation system MARS, plasmapheresis PE, plasmafiltration adsorption system PSAS.
In a second aspect, there is provided a method of connecting a blood purification circuit, comprising: connecting a common line assembly comprising an arterial line, a venous line, a fluid replacement line, and a filtrate line, the common line assembly adapted for use in any one of a plurality of treatment modes; connecting the common line assembly and a target filter using a target auxiliary line assembly to form a continuous blood purification line suitable for a target treatment mode, the target filter comprising one or more filters; the arterial line is provided with first input joint and first output joint, first input joint is connected with the arterial puncture needle on one's body of patient, first output joint with the target filter is connected, venous line is provided with second input joint and second output joint, the second input joint with the target filter is connected, the second output joint with the venous puncture needle on one's body of patient is connected, the fluid replacement line is provided with third input joint and third output joint, third input joint is connected with the fluid replacement container, the filtrate line is provided with fourth input joint and fourth output joint, fourth output joint is connected with the waste liquid container.
In a third aspect, there is provided a line fixture for securing a common line assembly in a blood purification line, the common line assembly including an arterial line, a venous line, a fluid replacement line, and a filtrate line, the common line assembly being adapted for use in any one of a plurality of treatment modes, the blood purification line further including a target auxiliary line assembly for connecting the common line assembly and a target filter such that the blood purification line is a continuous line adapted for use in a target treatment mode, the target filter including one or more filters, the line fixture comprising: the mounting plate is mounted on the front face of the blood purification device corresponding to the blood purification pipeline, and is provided with a plurality of through holes which are matched with a plurality of pumps of the blood purification device so as to expose the pumps; the pipe clamps are positioned on one side of the mounting plate, part of the pipe clamps are arranged along a first direction of the mounting plate, and the other part of the pipe clamps are arranged along a second direction so as to fix the pipe body in the public pipeline assembly along the first direction and the second direction respectively, wherein the first direction is different from the second direction.
In one possible embodiment, a portion of the plurality of through holes is used to expose one or more of: venous pot clamp, venous clamp, bubble monitoring element in the blood purification device.
In one possible embodiment, the plurality of pumps includes a blood pump, a first liquid pump, a second liquid pump, and a filtrate pump, and the plurality of through holes include, as viewed in a direction perpendicular to a front face of the blood purification apparatus: the first through hole is positioned at the upper right of the mounting plate and used for exposing the blood pump; and/or a second through hole, which is positioned at the upper left of the mounting plate and used for exposing the second liquid pump; and/or a third through hole is positioned at the left lower part of the mounting plate and used for exposing the first liquid pump; and/or a fourth through hole, which is positioned at the right lower part of the mounting plate and used for exposing the filtrate pump; and/or a fifth through hole is positioned at the left side of the first through hole and used for exposing the venous kettle clamp.
In one possible embodiment, the pipe clamp is an elastic pipe clamp having a groove for receiving the pipe body, the elastic pipe clamp being provided with an opening for the pipe body to be snapped in or pulled out.
In one possible embodiment, the mounting plate is a flat plate.
In one possible embodiment, the mounting plate is a transparent plate.
In one possible embodiment, the connection between the mounting plate and the blood purification device is any one of adhesion, fastening, and hanging.
In one possible embodiment, when the connection between the mounting plate and the blood purification apparatus is in a hanging manner, the tube fixing device includes: the hanging buckles are arranged at the top of the second side of the mounting plate, the second side is opposite to the mounting side of the pipe clamps, and the hanging buckles are respectively connected with the hooks arranged on the blood purifying device.
In one possible embodiment, the plurality of pipe clamps are fixed to the mounting plate in any one of the following ways: bonding, bolting and sliding clamping.
In one possible embodiment, the plurality of tube clamps are integrally formed with the mounting plate.
In one possible embodiment, the plurality of tube clamps are formed by means of suction moulding.
In one possible embodiment, the first direction is a horizontal direction and the second direction is a vertical direction.
According to the application, through the mode of collocating and connecting the public pipeline component and the target auxiliary pipeline component, the requirements of the blood purification pipelines of various clinical treatment modes can be met, and the blood purification pipelines can be prevented from being independently customized for each treatment mode. The application is beneficial to reducing the investment of resources such as manpower management, sites and the like in hospitals, reducing the cost, simplifying the installation steps, reducing the installation and switching time and reducing the taking over errors.
The application can rapidly complete the positioning and the installation of the arterial pipeline, the venous pipeline, the fluid supplementing pipeline and the filtrate pipeline by only installing the pipeline fixing device with the public pipeline component on the blood purifying equipment. The public pipeline assembly is arranged on the pipeline fixing device, the pipeline trend is clear and visual, the connection time of the blood purification pipeline is reduced, and the risk of wrong connection of the pipeline is reduced.
Drawings
Fig. 1 is a schematic diagram of connection of a blood purifying tube according to an embodiment of the present application.
Fig. 2 is a schematic view of a common line assembly in the blood purification line of fig. 1.
Fig. 3 is a schematic diagram of an auxiliary pipeline according to an embodiment of the present application.
Fig. 4 is a schematic view of a pipe fixing device according to an embodiment of the present application.
Fig. 5 is a schematic view of one possible securing means of the utility line assembly of fig. 2.
Fig. 6 is a schematic diagram of one possible implementation of the blood purification circuit of fig. 1.
Fig. 7 is a schematic diagram of another possible implementation of the blood purification circuit of fig. 1.
Fig. 8 is a schematic diagram of yet another possible implementation of the blood purification circuit of fig. 1.
Fig. 9 is a schematic diagram of yet another possible implementation of the blood purification circuit of fig. 1.
Fig. 10 is a flow chart of a method for connecting a blood purifying line according to an embodiment of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. It will be apparent that the described embodiments are only some, but not all, embodiments of the application. The same or similar reference numbers are used in the drawings to refer to the same or similar modules. It is to be understood that the drawings are merely illustrative and that the scope of the application is not limited thereto.
Continuous blood purification is initially used for treating Acute Renal Failure (ARF), and through continuous research and exploration, the application range is expanded to severe wounds, sepsis, multi-organ failure, severe heart failure, acute respiratory failure and the like, and the continuous blood purification is recently developed into auxiliary treatment of technologies such as an artificial liver support system, a nerve immune system, cell purification and the like, and becomes an important support measure for treating various critical diseases.
Continuous blood purification treatment is a treatment mode in which blood is led out of the body, harmful substances and moisture in the blood are removed through a purification device, and the purified blood is conveyed back into the body. The blood purifying pipeline is a consumable product necessary for continuous blood purifying treatment, is used as a circulating channel of extracorporeal blood and a flowing channel of replacement liquid, dialyzate, blood plasma and the like, and is matched with special blood purifying equipment.
The continuous blood purifying pipeline mainly comprises an arterial pipeline, a venous pipeline, a fluid supplementing pipeline, a filtrate pipeline and the like. The arterial line guides the blood to flow out of the body, flows into a dialyzer, a perfusion device, a plasma separator, a filter and other filters, removes pathogenic sources, moisture, toxic substances, metabolic wastes and the like in the blood, and then returns the purified blood to the human body through the venous line. The fluid infusion pipeline or the integrated pipeline and the replacement pipeline can comprise a heating pipe and a fluid infusion pipe, and the fluid infusion pipe can be used for conveying anticoagulant, sodium bicarbonate solution and other solutions. The dialyzate enters the dialyser through the heating tube, and the blood purification effect is realized based on the dispersion, convection and adsorption principles. The replacement fluid can enter the blood from the warming tube to maintain the electrolyte and acid-base balance in the blood.
The continuous blood purification treatment modes commonly used in clinic at present mainly comprise: slow continuous ultrafiltration (slow continuous ultrafiltration, SCUF), continuous intravenous-venous hemofiltration (continuous veno-venous hemofiltration, CVVH), continuous intravenous-venous hemodiafiltration (continuous intravenous hemodialysis filtration, CVVHDF), continuous intravenous-venous hemodialysis (continuous veno-venous hemodialysis, CVVHD).
Along with the gradual deepening of the understanding of disease pathogenesis, blood purification modes and mechanisms and disease curative effects, at present, students at home and abroad all claim to adopt two or more than two different blood purification principles or hybrid blood purification technologies formed by combining (or integrating) technologies so as to realize different blood purification purposes. Based on this concept, some newer therapeutic or combination modes have also been developed and applied, such as double filtration plasmapheresis (double filtration PLASMA PHERESISN, DFPP), plasmafiltration (plasma adsorption, PA), plasmafiltration (PLASMA DIALYSIS filtration, PDF), double plasma molecular adsorption systems (double plasma molecular absorb system, DPMAS), continuous plasmafiltration, etc.
The blood purification lines provided by manufacturers of continuous blood purification treatment equipment to hospitals are generally adapted for use in conventional treatment modalities. Namely, can satisfy: slow continuous ultrafiltration, continuous intravenous hemofiltration, continuous intravenous hemodiafiltration, continuous intravenous hemodialysis. When the department of the hospital needs to switch to other treatment modes, the current blood purification pipeline cannot meet the requirements, and the hospital is required to customize the blood purification pipeline corresponding to each treatment mode independently to a consumable manufacturer.
When blood purification treatment is clinically carried out, medical staff is required to install the prepared filter, pipeline consumable and other necessities on blood purification equipment, and then the treatment is carried out according to the requirement of regulations. In the process of installing pipelines, the installation of consumable materials on pipelines is particularly time-consuming. According to different treatment modes, medical staff may need to spend 10-30 minutes to install the pipeline consumable, pipeline elements of complex treatment modes are more, and the pipeline is easy to connect by mistake in the installation process, so that the treatment plan of a patient is affected.
In summary, in the face of multiple treatment modes, hospitals need to be provided with more corresponding pipelines, so that resources such as manpower and places of the hospitals can be occupied, the cost is increased, different blood purification pipelines are needed in multiple treatment modes, and the time for selecting and installing the pipelines and the risk of wrong connection of the pipelines in the treatment process can be increased.
Based on the above, the embodiment of the application provides a blood purifying pipeline. Fig. 1 is a schematic diagram of a blood purification circuit according to an embodiment of the present application. It will be appreciated that the blood purification circuit needs to be used with a corresponding blood purification device. The blood purification circuit according to the embodiment of the present application will be described in detail with reference to fig. 1. As shown in fig. 1, the blood purification circuit 100 may include: a common line assembly 110 and a target auxiliary line assembly 120.
The common line assembly 110 may include an arterial line 111, a venous line 112, a make-up line 113, and a filtrate line 114. The common line assembly 110, alternatively referred to as a base line module, a common line module, the common line assembly 110 is adapted for use in any of a plurality of treatment modes.
Arterial line 111 is used to direct blood in the patient's body to a target filter to remove pathogenic sources, moisture, toxic substances, metabolic waste, and the like from the blood. The target filter includes one or more filters, which may be, for example, a dialyzer, a perfusion, a plasma separator, a filter, or the like. The primary interface of the target filter is typically a dialyzer interface. The venous line 112 is used to introduce the blood purified by the target filter into the patient. The fluid supply line 113, alternatively referred to as an integrated line, a substitution line, is used to supply fluid to the subject filter, arterial line 111, and/or venous line 112. The fluid replacement line 113 may include a warming tube and a fluid replacement tube, which may deliver anticoagulant, sodium bicarbonate solution, dialysate, replacement fluid, and the like. The filtrate line 114 is used for treating the waste liquid generated after the liquid replenished from the replenishing line 113 passes through the target filter.
Arterial line 111 may be provided with a first input connector for connection to an arterial needle on a patient (or indwelling in vivo) and a first output connector for connection to a target filter comprising one or more filters. The venous line 112 may be provided with a second input connector that is connected to the target filter and a second output connector that is connected to a venipuncture needle on the patient. The replenishing line 113 is provided with a third input connection and a third output connection, the third input connection being connected to the replenishing container. The replenishment liquid may be, for example, a replacement liquid, an albumin liquid, or a dialysis liquid, and the replenishment liquid container may be, for example, a replacement liquid bag, an albumin liquid bag, or a dialysis liquid bag. The filtrate line 114 is provided with a fourth input connection and a fourth output connection, which is connected to the waste liquid container. The waste container may be, for example, a waste bag. Wherein the first output connector mates with the connector of the target filter to facilitate direct connection with the connector of the target filter. The second input connector mates with the connector of the target filter to facilitate a direct connection with the connector of the target filter.
In some implementations, the first output connector and the second input connector are dialysis connectors, alternatively referred to as dialyzer connectors, the dialysis connectors being sized to meet the requirements of the YY 0267 standard.
The tubing elements comprising the common tubing assembly 110 are sized to meet medical device specifications. For example, the outer diameter of the tube body of the common line assembly 110 may be, for example, 3.2-4.5 mm. The tube body of the common pipeline assembly 110 may be made of medical PVC, PP, PE, ABS, PC, silica gel, TPFE, or the like. The connection between the injection molding part and the pipeline can be realized by bonding medical-grade liquid glue such as UV glue, epoxy glue and the like.
The plurality of treatment modes includes at least some or all of the following treatment modes: slow Continuous Ultrafiltration (SCUF), continuous intravenous hemofiltration (CVVH), continuous intravenous hemodiafiltration (CVVHDF), continuous intravenous hemodialysis (CVVHD), double filtration plasmapheresis (DFPP), plasma Adsorption (PA), plasmafiltration (PDF), double Plasma Molecular Adsorption System (DPMAS), paired plasmafiltration adsorption (coupled plasma filtration absorption, CPFA), blood perfusion (hemo-infusion, HP), repeated albumin dialysis (REPETITIVE ALBUMIN DIALYSIS, RAD), single pass albumin DIALYSIS SPAD, molecular adsorption recirculation system (molecular adsorbent RECYCLING SYSTEM, MARS), plasmapheresis (plasma exchange, PE), plasma separation adsorption system (plasma separation and adsorption system, PSAS).
In some implementations, the target filter 130 may be part or all of a hemofilter, hemodialyzer, plasma separator, perfusion, adsorber, or the like. The target filter 130 typically has a dialysis adapter.
In some implementations, the first output connector and the second input connector are dialysis connectors. The third output connector and the fourth input connector may be male connectors. The male connector, or outer connector, may be a luer connector with male threads, the size of which meets the requirements of GB/T1962.2. The male connector can be a rotary connector or a wing type rotary connector.
Fig. 2 is a schematic diagram of one possible implementation of a common line assembly in the blood purification line of fig. 1. Common line assembly 110 may include various types of line elements, each of which is shown in Table 1 with corresponding serial numbers for ease of illustration.
Table 1 names and numbers of elements in common line assembly 110
| Sequence number | Name of the name | Sequence number | Name of the name |
| 16 | T-shaped three-way joint | 27 | Blood pump tube clamp |
| 17 | Female connector | 28 | Filter liquid pump pipe clamp |
| 18 | Male connector | 29 | Pot cover |
| 19 | Adapter connector | 30 | Air pot |
| 20 | Heating liquid bag | 31 | Filter screen |
| 21 | Liquid pump pipe clamp | 32 | Plasma pot |
| 22 | Sensor protector | 33 | Hansen joint |
| 23 | Three-way check valve | 34 | Y-shaped three-way joint |
| 24 | Sampling port | P1 | Integrated pipeline pump pipe |
| 25 | Dialysis joint | P2 | Arterial pipeline pump pipe |
| 26 | Heparin one-way valve | P3 | Pump pipe of filtrate pipeline |
The common line assembly 110 may also include a plurality of make-up and pressure taps. Wherein, any fluid infusion branch pipe can include: heparin check valve, preset length's body. The plurality of fluid-supplementing branch pipes may be divided into, for example: the first fluid supplementing branch pipe and the second fluid supplementing branch pipe. Any of the pressure manifolds may comprise: sensor protector, female joint, the body of predetermineeing length. The plurality of pressure measuring branch pipes may be divided into, for example: the first pressure measuring branch pipe and the second pressure measuring branch pipe. The various make-up branches, pressure taps, and corresponding serial numbers in the common line assembly 110 are shown in table 2 and fig. 2.
The specific composition of the common line assembly 110 is described in exemplary fashion below.
As shown in fig. 2, the arterial line 111 may include: the device comprises a male connector 18, a sampling port 24, 5T-shaped three-way connectors 16, an arterial line first pressure measuring branch pipe B6, an arterial line first fluid supplementing branch pipe B7, an arterial line second fluid supplementing branch pipe B8, an arterial line second pressure measuring branch pipe B9, an arterial line third fluid supplementing branch pipe B10, a blood pump pipe clamp 27, an arterial line pump pipe P2, a three-way check valve 23 and a dialysis connector 25. The first inlet connection of the arterial line 111 is the male connection 18 and the first outlet connection is the dialysis connection 25. During treatment, arterial line pump tube P2 is mounted to the blood pump of the blood purification device by blood pump tube clamp 27 for providing the motive force for blood flow during treatment. The first input connector (male connector 18) is used for connection to a device to be placed in the patient, such as a puncture outfit, catheter, etc. The dialysis adapter 25 is used to connect a target filter, such as a hemodialyzer, hemofilter, plasma separator, etc., for use in therapy. The three-way check valve 23 can be used for connecting male connectors of other pipelines, and can supplement liquid such as replacement liquid into the arterial pipeline 111 through the connection, and the three-way check valve 23 has the characteristic of unidirectional circulation, so that the liquid can be only supplemented by the other pipelines, but the liquid of the arterial pipeline 111 cannot enter the other pipelines through the connectors. During treatment, the arterial Pressure (PA) and the pre-filtration Pressure (PBE) of the blood line during treatment may be monitored by connecting the sensor protector 22 on the arterial line first pressure manifold B6 and the arterial line second pressure manifold B9 to the pressure sensor of the blood purification device. And through the female connector 17 on the first fluid infusion branch pipe B7, the second fluid infusion branch pipe B8 and the third fluid infusion branch pipe B10, heparin anticoagulant, naHCO3 solution, sodium citrate solution and the like can be supplemented according to the requirements in the treatment process. The sampling port 24 is provided with a silica gel pad which is soft, and medical staff can use a proper puncture needle to take blood of a patient just led out of a human body for detection through the silica gel pad.
Table 2 fluid make-up and pressure tap in utility line assembly 110
| Sequence number | Name of the name | Sequence number | Name of the name |
| B1 | First fluid supplementing branch pipe of fluid supplementing pipeline | B6 | First pressure measuring branch pipe of arterial line |
| B2 | Second fluid supplementing branch pipe of fluid supplementing pipeline | B7 | First fluid supplementing branch pipe of arterial pipeline |
| B3 | Pressure measuring branch pipe for venous pipeline | B8 | Second fluid supplementing branch pipe of arterial pipeline |
| B4 | First fluid infusion branch pipe of venous line | B9 | Second pressure measuring branch pipe of arterial line |
| B5 | Second fluid supplementing branch pipe of venous line | B10 | Third fluid supplementing branch pipe of arterial pipeline |
| B11 | Filtrate pipeline pressure measuring branch pipe |
The venous line 112 may include: dialysis joint 25, sampling port 24, three-way check valve 23, air pot 30, filter screen 31, T three-way joint 16, male joint 18, venous line pressure measurement branch pipe B3, venous line first fluid infusion branch pipe B4, venous line second fluid infusion branch pipe B5. The second input connector of the venous line 112 is a dialysis connector 25, and the second output connector is a male connector 18. The air pot 30 or vein pot is installed on the air pot clamp of the blood purifying device for capturing air, and the filter screen 31 in the air pot 30 can effectively filter blood clots in blood to prevent the blood clots from entering human body and form thrombus. The sensor protector 22 on the venous line pressure measuring branch B3 is connected to a sensor of the blood purifying apparatus, and can monitor the Pressure (PV) change at the venous side. The venous line first fluid replacement branch B4 and the venous line second fluid replacement branch B5 may be used to supplement replacement fluid, calcium-containing solution, and the like. Male connector 18 may then be used to connect to an indwelling device in a patient, such as a puncture device, catheter, etc., to effect circulation of the patient's blood from arterial line 111 out of venous line 112.
The fluid replacement line 113 may include: 2 male connectors 18, an integrated pipeline pump pipe P1, a liquid pump pipe clamp 21, a heating liquid bag 20, 2 conversion connectors 19, a temperature measuring pipe 15, a first fluid supplementing branch pipe B1 of a fluid supplementing pipeline and a second fluid supplementing branch pipe B2 of the fluid supplementing pipeline. The third input connector and the third output connector of the fluid infusion line 113 are the same in type and are male connectors 18. The integrated circuit pump line P1 and pump clamp 21 may be mounted on a dialysate pump of a blood purification device to power fluid flow in the fluid replacement line 113. The heating fluid bag 20 may be installed in a heating unit of the blood purification apparatus, and the heating fluid bag 20 and the heating unit may heat the fluid flowing through the heating fluid bag 20 to a proper temperature and then fill the arterial line 111, the venous line 112, the filter side branch, or the like. The temperature measuring tube 15 is installed in a temperature measuring component of the device, and whether the temperature of the heated liquid reaches the expected requirement can be measured through the temperature measuring component. The first fluid-supplementing branch B1 of the fluid-supplementing line may be used to supplement the arterial line 111 or the venous line 112 by diverting a portion of the heated fluid from the fluid bag according to the requirements of the treatment mode, such as the CVVHDF treatment mode, and the second fluid-supplementing branch B2 of the fluid-supplementing line may be used to supplement the fluid from other lines. The third input connector (male connector 18) is close to the liquid pump tube clamp 21 and is used for connecting various liquid bags, such as a replacement liquid bag, a plasma bag and the like, and guiding corresponding liquid into the liquid supplementing pipeline 113. According to the requirements of different treatment modes, the third output connector is connected with different short pipes and then connected with the filter. In the CVVHDF treatment mode, the auxiliary pipeline is connected with the side branch of the hemofilter, and the replacement liquid is introduced into the dialysate chamber of the hemofilter to exchange substances with the blood flowing through the blood chamber of the hemofilter through the membrane of the filter.
The filtrate line 114 may include: 2 male connectors 18, a filtrate pipeline pump pipe P3, a filtrate pump pipe clamp 28, a sampling port 24 and a filtrate pipeline pressure measuring branch pipe B11. The fourth input connector of the filtrate line 113 is a male connector 18, and the fourth output connector is also a male connector 18. The fourth input connector (male connector 18) is close to the T-joint 16, can be connected with different short pipes according to treatment modes, and then is connected with a target filter, so that liquid is introduced into the filtrate pipeline pump pipe P3. The fourth output connector can be connected with different short pipes and then connected with devices such as a target filter or a waste liquid bag, and the like, so that the function of discharging liquid from the filtrate pipeline 114 is realized.
It is understood that the utility line assembly 110 may include a plurality of different line elements, and that the utility line assembly 110 may be implemented in a variety of combinations, and that the types and numbers of elements, and implementations of the utility line assembly 110 are not particularly limited in embodiments of the present application.
The target auxiliary line assembly 120 is used to connect the common line assembly 110 and the target filter 130 such that the blood purification line 100 is a continuous line suitable for the target treatment mode. Target filter 130 may include one or more filters.
The target treatment pattern is a desired (achieved) blood purification treatment pattern, and the target treatment pattern may be any of the plurality of treatment patterns described above. The target treatment modality may be, for example, continuous intravenous hemodiafiltration, double filtration plasmapheresis, molecular adsorption recirculation systems.
The target auxiliary line assembly 120 may be comprised of one or more auxiliary lines, which may be the same or different types. Alternatively, the plurality of auxiliary lines may be of a plurality of types and the target auxiliary line assembly 120 may be comprised of a plurality of identical and/or different types of auxiliary lines.
Any of the one or more auxiliary lines may be composed of at least some of the following elements: female joint, male joint, dialysis joint, T-shaped three-way joint, Y-shaped three-way joint, body, liquid pump pipe clamp, pump pipe, plasma pot, hansen joint, pressure measuring branch pipe, fluid supplementing branch pipe. The fittings of the elements making up any of the auxiliary lines are matched to facilitate direct or quick connection. For example, a male connector of 6mm in size is connected to a T-shaped three-way connector of the same size as 6 mm. In some implementations, the pressure manifold may include a sensor protector and a female connector, and the fluid replacement manifold may include a female connector.
In some implementations, the target filter may include a portion or all of a hemofilter, a hemodialyzer, a plasma separator, a perfusion, an adsorber.
Fig. 3 is a schematic diagram of various auxiliary pipelines according to an embodiment of the present application. As shown in fig. 3, the various auxiliary lines may include: auxiliary line A (301), auxiliary line B (302), auxiliary line C (303), auxiliary line D (304), auxiliary line E (305), auxiliary line F (306), auxiliary line G (307), auxiliary line H (308), auxiliary line I (309), auxiliary line J (310), auxiliary line K (311). Auxiliary line a is alternatively referred to as a first type of auxiliary line and auxiliary line B is alternatively referred to as a second type of auxiliary line. For example, the auxiliary line a (301) may include: 2 male connectors 18, a first pump pipe P4 of a fluid supplementing pipeline, a liquid pump pipe clamp 21, a kettle cover 29, a plasma kettle 32, a pressure measuring branch pipe B12, a fluid supplementing branch pipe B13 and a pipe body with preset length. Any of the pressure taps B12 may include a sensor protector 22 and a female connector 17, and any of the fluid make-up taps B13 may include a female connector 17. As another example, auxiliary line B (302) may include: 2 male connectors 18, a second pump pipe P5 of the fluid supplementing pipeline, a liquid pump pipe clamp 21 and a pipe body with a preset length. For another example, the auxiliary line C (303) may include: 2 dialysis connectors 25, a T-shaped three-way connector 16, a fluid supplementing branch pipe B13 and a pipe body with a preset length.
According to different treatment modes, corresponding auxiliary pipelines are selected to form a target auxiliary pipeline assembly for connection, and support of multiple treatment modes can be achieved. Table 3 lists target auxiliary line assemblies for a plurality of treatment modes supported by the blood purification line according to embodiments of the present application, wherein the target auxiliary line assemblies may include one or more auxiliary lines, and the types of the plurality of auxiliary lines may be the same or different. I.e., the plurality of treatment modes have a mapping relationship with the target auxiliary line assembly.
TABLE 3 multiple treatment modes and corresponding target auxiliary line assemblies
For example, when the target treatment mode is CVVHDF, the target auxiliary line assembly may include 1 auxiliary line B, 2 auxiliary lines I. When the target treatment mode is DFPP, the target auxiliary line assembly may include 1 auxiliary line a, 2 auxiliary lines G,1 auxiliary line I, 1 auxiliary line J. When the target treatment mode is MARS, the target auxiliary line assembly may include 1 auxiliary line a, 1 auxiliary line C, 1 auxiliary line D, 1 auxiliary line F, 1 auxiliary line G,4 auxiliary lines I. When the treatment mode is switched, the common pipeline assembly 110 is partially unchanged, and the blood purifying pipeline corresponding to the target treatment mode can be obtained only by replacing the corresponding target auxiliary pipeline assembly.
According to the embodiment of the application, the mode of matching and connecting the public pipeline component and the target auxiliary pipeline component can meet the pipeline requirements of multiple clinical blood purification treatment modes, and the condition that a hospital subscribes the blood purification pipeline for each treatment mode independently is avoided. The hospital can meet the requirements of multiple treatment modes by ordering a common pipeline component and a small number of auxiliary pipelines with corresponding specifications. The embodiment of the application does not need to independently customize the corresponding blood purification pipelines for each treatment mode, is beneficial to reducing the input of resources such as manpower, sites and the like for hospital management and saves the cost. The common pipeline assembly is convenient to install, and is beneficial to simplifying the installation steps, reducing the installation and switching time and reducing the connecting pipe errors.
The blood purification circuit is typically located on the front side of the blood purification device. The front detection elements and functional modules (such as a liquid pump) of the blood purification equipment are more, the space is more tense, the blood purification pipeline is generally fixed on the front of the blood purification equipment in a hanging mode, and the arrangement and trend of the blood purification pipeline are not visual. In addition, the branch circuits and elements in the blood purifying pipeline are more, the risk of the pipeline being connected in error is high, and the installation time is long.
Fig. 4 is a schematic view of a pipe fixing device according to an embodiment of the present application. The pipe fixing device according to the embodiment of the present application will be described in detail with reference to fig. 4. The line fixture 400 is used to fix a common line assembly 110 in the blood purification line 100 of fig. 1, the common line assembly 110 including an arterial line 111, a venous line 112, a fluid replacement line 113, and a filtrate line 114, the common line assembly 110 being adapted for any of a plurality of treatment modes. The blood purification circuit 100 further includes a target auxiliary circuit assembly 120 for connecting the common circuit assembly and the target filter, which may include one or more filters, such that the blood purification circuit is a continuous circuit suitable for the target treatment mode. In some embodiments, the blood purification circuit 100 may include a circuit fixture 400.
As shown in fig. 4, the pipe fixing device 400 may include: a mounting plate 410 and a plurality of tube clamps 420.
The mounting plate 410 is mounted on the front surface of the blood purification apparatus corresponding to the blood purification tube. The mounting plate 410 is provided with a plurality of through holes, in which the plurality of through holes are matched with the plurality of pumps on the front surface of the blood purification apparatus, for exposing the plurality of pumps. Or a portion of the plurality of through holes (or referred to as a first set of through holes) is mated with the plurality of pumps of the blood purification apparatus for exposing the plurality of pumps. The blood purification pipeline is required to be matched with corresponding blood purification equipment.
In some implementations, a portion of the plurality of vias (or referred to as a second set of vias) is used to expose one or more of: venous pot clamp, venous clamp, bubble monitoring element in blood purification device.
In some implementations, the plurality of pumps may include a blood pump, a first liquid pump, a second liquid pump, and a filtrate pump, wherein the blood pump corresponds to an arterial line, the first liquid pump and the second liquid pump correspond to a fluid replacement line, and the filtrate pump corresponds to a filtrate line. As shown in fig. 4, the plurality of through holes may include, for example, as viewed in a direction perpendicular to the front face of the blood purification apparatus: a first through hole 411, located at the upper right of the mounting plate 410, for exposing the blood pump; and/or a second through hole 412 located at the upper left of the mounting plate 410 for exposing the second liquid pump; and/or a third through hole 413 located at the lower left side of the mounting plate 410 for exposing the first liquid pump; and/or a fourth through hole 414, located at the lower right of the mounting plate, for exposing the filtrate pump; and/or a fifth through hole 415 located at the left side of the first through hole 411 and at the right side of the second through hole 412 for exposing the venous pot clamp. In some embodiments, the perimeter of the plurality of through holes may be rounded or chamfered. The embodiment of the application does not limit the specific size and pattern of each through hole, as long as the corresponding functional module is exposed. It will be appreciated that some of the plurality of through holes may be combined into one larger through hole, as long as the corresponding function is achieved.
In some implementations, the first through hole 411 is used to expose the blood pump and filter clip.
In some implementations, the plurality of vias may also include a sixth via 416, the sixth via 416 being located below the fifth via 415 for bubble monitoring. In some implementations, the plurality of through holes may further include a seventh through hole 417, the seventh through hole 417 being located below the sixth through hole 416 for exposing the venous clip.
A plurality of tube clamps 420 are located on one side of the mounting plate 410. For ease of illustration, in an embodiment of the present application, the side of the plurality of tube clamps 420 is the front side of the mounting plate 410. A portion of the plurality of tube clamps 420 may be disposed along a first direction of the mounting plate 410 and another portion of the plurality of tube clamps may be disposed along a second direction to secure the tubes in the utility line assembly along the first direction and the second direction, respectively, the first direction being different from the second direction. The number of the plurality of pipe clamps 420 is not limited in the embodiment of the present application, and for example, the pipe clamps 420 may be 14. In some implementations, the first direction is perpendicular to the second direction.
In some embodiments, the first direction may be a horizontal direction and the second direction may be a vertical direction. The pipeline is arranged horizontally and vertically, and the trend is clear and visual.
In some implementations, the plurality of tube clamps 420 may be resilient tube clamps. The elastic pipe buckle is provided with a groove for accommodating the pipe body, the elastic pipe buckle is provided with an opening part, and the opening part is used for conveniently clamping in or pulling out the pipe body, so that the quick installation or adjustment of the pipe body is facilitated.
In some implementations, mounting plate 410 may be a flat plate. This facilitates complete engagement with the surface of the decontamination apparatus, facilitating the overall movement of the utility line assembly portion.
In some implementations, mounting plate 410 may be a transparent plate. This helps to show the detection element and instrument panel on the front of the decontamination apparatus, avoiding obscuring the detection element on the front of the decontamination apparatus. In some embodiments, mounting plate 410 may be composed of a polymeric material. In other embodiments, mounting plate 410 may be composed of a sterile, antistatic material.
In some implementations, the perimeter of mounting plate 410 may be rounded or chamfered to avoid raised corners.
In some implementations, the connection between mounting plate 410 and the blood purification device may be any one or a combination of adhesive, snap-fit, and suspension.
In some implementations, where the connection between mounting plate 410 and the blood purification apparatus is a hanging type, tubing set 400 includes a plurality of hanging buttons 430. The plurality of hanging buttons 430 are provided on top of a second side of the mounting plate 410, which is opposite to the mounting side of the plurality of pipe clamps 420, and the plurality of hanging buttons 430 are respectively connected with a plurality of hooks (hanging buttons) provided on the blood purifying apparatus. In some embodiments, the plurality of suspension buttons 430 may be 2 suspension buttons, which is simple and stable to install.
In some implementations, the plurality of tube clamps 420 may be secured to the mounting plate 410 in any of the following ways: bonding, bolting and sliding clamping.
In some implementations, the plurality of tube clamps 420 may be integrally formed with the mounting plate 410.
In some implementations, the plurality of tube clamps 420 may be created by means of suction molding. The plastic suction molding is favorable for quickly forming a complex structure and reducing material consumption.
In some implementations, the plurality of treatment modes includes at least some or all of the following treatment modes: slow continuous ultrafiltration, continuous intravenous hemofiltration, continuous intravenous hemodiafiltration, continuous intravenous hemodialysis, double filtration plasmapheresis, plasmafiltration, double plasmafiltration molecular adsorption system, paired plasmafiltration adsorption, hemoperfusion, repeated albumin dialysis, single albumin pass dialysis, molecular adsorption recirculation system, plasmafiltration adsorption system.
According to the embodiment of the application, the common pipeline components including the arterial pipeline, the venous pipeline, the fluid infusion pipeline and the filtrate pipeline can be fixed on the pipeline fixing device, and medical staff can quickly complete the positioning and the installation of the arterial pipeline, the venous pipeline, the fluid infusion pipeline and the filtrate pipeline by only installing the pipeline fixing device with the common pipeline components on the fixing position of the blood purifying equipment when installing the pipeline. The public pipeline assembly is arranged on the pipeline fixing device, the pipeline trend is clear and visual, the pipe fitting is accurately arranged at the corresponding position of the blood purifying equipment, and medical staff is not required to independently install each pipe. The embodiment of the application is beneficial to reducing the operation steps of medical staff, prolonging the connection time and reducing the risk of connecting the pipelines with errors.
Fig. 5 is a schematic view of one possible fastening means of the pipe fastening device of fig. 4. As shown in fig. 5, the mounting plate 410 is a flat plate made of a polymer material, and a part of through holes among the plurality of through holes on the mounting plate 410 are matched with the plurality of pumps of the blood purifying apparatus for exposing the plurality of pumps. Another part of the plurality of through holes is used for exposing a venous pot clamp, a venous clamp and a bubble monitoring element in the blood purifying device.
A portion of the plurality of tube clamps 420 may be arranged in a first direction of the mounting plate 410 and another portion of the plurality of tube clamps 420 may be arranged in a second direction. The pipe bodies in the common line assembly may be fixed in a first direction and a second direction, respectively. Wherein the first direction is a horizontal direction and the second direction is a vertical direction. For example, the pipe body of the fluid infusion pipeline is fixed along the horizontal direction. The pipeline is arranged horizontally and vertically, and the trend is clear and visual.
The plurality of tube clamps 420 may be elastic buttons. The elastic pipe buckle is provided with a groove for accommodating the pipe body, the elastic pipe buckle is provided with an opening part, and the opening part is used for conveniently clamping in or pulling out the pipe body.
According to the embodiment of the application, when a medical staff installs the pipeline, the positioning and the installation of the arterial pipeline, the venous pipeline, the fluid supplementing pipeline and the filtrate pipeline can be rapidly completed only by installing the pipeline fixing device with the public pipeline component at the fixing position of the blood purifying equipment. During treatment, the common pipeline assembly can be preassembled on the pipeline fixing device and then integrally hung on the blood purifying equipment, so that treatment waiting time can be reduced; when the treatment mode is switched, the common pipeline components assembled on the pipeline fixing device are not disassembled, and only the corresponding auxiliary pipeline components are required to be replaced. According to the embodiment of the application, the public pipeline assembly is arranged on the pipeline fixing device, the trend of the pipeline is clear and visual, the operation steps and the connection time of medical staff are reduced, and the risk of pipeline connection errors is reduced.
Embodiments of the present application are further described below in conjunction with some of the possible implementations of the present application.
Fig. 6 is a schematic diagram of one possible implementation of the blood purification circuit of fig. 1. As shown in fig. 6, the blood purification line 600 is suitable for use in a continuous intravenous hemodiafiltration (CVVHDF) pre-dilution treatment mode. The blood purification circuit 600 may include: common line assembly 110, target auxiliary line assembly 620. The common line assembly 110 includes an arterial line 111, a venous line 112, a make-up line 113, and a filtrate line 114. The target auxiliary line assembly 620 includes 1 auxiliary line B (302), 2 auxiliary lines I, i.e., the target auxiliary line assembly 620 may include: auxiliary line B (302), first auxiliary line I (corresponding to reference 621), second auxiliary line I (622). The target filter for the CVVHDF treatment mode is hemofilter 35. In addition, the consumable that cooperation pipeline used still includes: a waste liquid bag 36 and a replacement liquid bag 37.
The main operation of each line portion of the blood purification line 600 will be exemplarily described with respect to the serial intravenous hemodiafiltration pre-dilution therapy mode.
1. The operation of arterial line 111. The arterial line pump tube P2 and the blood pump tube clip 27 are mounted on a blood pump of the blood purifying apparatus to provide motive power for blood flow. And a first inlet port (model male port 18) of arterial line 111 is connected to an indwelling device within the patient, and draws the patient's blood. The first output connector (dialyzer connector 25) is connected to a first blood chamber end (input) of the hemofilter 35, and patient blood flows through the arterial line 111 and into the blood chamber of the hemofilter 35. The sampling port 24 is provided with a silica gel pad which is soft, and medical staff can use a proper puncture needle to take blood of a patient just led out of a human body for detection through the silica gel pad. The third fluid supplementing branch pipe B10 of the arterial line is provided with a heparin one-way valve 26, and citric acid solution can be supplemented into the arterial line through the heparin one-way valve 26 for anticoagulation of blood. The sensor protector 22 on the arterial line second pressure branch B9 is connected to a pressure sensor of the blood purification device for monitoring the arterial pressure change (PA). If the substitution liquid is fed in before (diluted before), the three-way check valve 23 is connected to the male connector 18 (far from the first liquid pump P1) at the output end of the auxiliary line B (302), and the substitution liquid is introduced from the auxiliary line B (302) into the arterial line 111. The sensor protector 22 on the arterial line first pressure branch B6 is connected to a pressure sensor of the blood purification device for monitoring the change in pre-filter Pressure (PBE). The first fluid supplementing branch pipe B7 of the arterial line is provided with a heparin one-way valve 26, and anticoagulants such as heparin can be supplemented into the arterial line through the heparin one-way valve 26 for anticoagulation of blood in the treatment process. The second fluid-supplementing branch pipe B8 of the arterial line is provided with a female joint 17 which can be used for independently supplementing NaHCO3 solution.
2. The operation of the venous line 112. The dialysis connector 25 (i.e., the second inlet connector) of the venous line 112 is connected to the second blood chamber end (outlet end) of the hemofilter 35 to introduce blood, which is then connected to the indwelling device in the patient's body via the male connector 18 (i.e., the second outlet connector) to circulate back into the patient's body. The vein sampling port 24 is provided with a soft silica gel pad, and medical staff can use a proper puncture needle to collect blood after passing through the filter through the silica gel pad for detection. The air pot 30 is to be mounted on the air pot clamp of the blood purifying device, and blood clots will be blocked in the air pot 30 and will not enter the patient to form thrombus when blood passes through the air pot 30 due to the filter screen 31 in the air pot 30. The sensor protector 22 on the pressure manifold B3 on the air pot 30 is connected to the pressure sensor of the blood purifying apparatus for monitoring the venous Pressure (PV). The first fluid-supplementing branch pipe B4 of the venous line serves as a backup line, where fluids such as replacement fluid can be supplemented. The second fluid supplementing branch pipe B5 of the venous line can be supplemented with a solution containing calcium ions according to the requirement.
3. And the working process of the fluid supplementing pipeline 113. The integrated circuit pump line P1 and pump clamp 21 are mounted on the dialysate pump of the blood purification device to power the flow of fluid in the fluid replacement line 113. The male connector 18 (i.e., the third input connector) adjacent the pump clamp 21 is connected to the replacement fluid bag 37 and directs the replacement fluid into the fluid replacement line 113. The male connector 18 (i.e., the third output connector) at the output of the fluid replacement line 113 is connected to the female connector 17 of the first auxiliary line I (621), while the hansen connector 33 of the first auxiliary line I (621) is connected to the first side branch of the hemofilter 35, and the replacement fluid in the fluid replacement line 113 is introduced into the dialysate chamber of the hemofilter and then subjected to mass exchange with the blood in the hemofilter chamber. The female connector 17 of the first fluid-replenishing branch pipe B1 of the fluid-replenishing line is connected to the male connector 18 (adjacent to the first liquid pump P1) of the input end of the auxiliary line B (302), and a part of the replacement fluid in the fluid-replenishing line 113 is introduced into the auxiliary line B (302) through the connection. The heating liquid bag 20 is mounted in a heating unit of the blood purifying apparatus, and the heating liquid bag 20 and the heating unit can heat the replacement liquid flowing through the heating liquid bag 20 to a temperature corresponding to the temperature of the human body, and then the replacement liquid can be supplied to the arterial line 111, the venous line 112, the filter side branch, or the like. The temperature measuring tube 15 is installed in a temperature measuring component of the blood purifying device, and whether the temperature of the heated liquid reaches the expected requirement can be measured through the temperature measuring component.
4. The operation of filtrate line 114. The filtrate line pump line P3 and the filtrate pump line clamp 28 are mounted to the filtrate pump of the blood purification apparatus to power the fluid in the filtrate line 114. The male connector 18 (i.e., the fourth input connector) adjacent to the T-junction 16 is connected to the female connector 17 of the second auxiliary line I (622), and the hansen connector 33 of the second auxiliary line I (622) is connected to the second side branch of the hemofilter 35, so that the waste liquid exchanged in the dialysate chamber of the hemofilter 35 can be introduced into the filtrate line 114. And the male connector 18 (fourth output connector) at the outlet end of the filtrate line 114 is connected to the waste liquid bag 36, and the waste liquid is introduced into the waste liquid bag 36 and collected. The sensor protector 22 on filtrate line pressure tap B11 is connected to a pressure sensor for monitoring the pressure change (PM 1) of filtrate line 114. The sampling port 24 is provided with a silica gel pad which is soft, and medical staff can use a proper puncture needle to take filtrate through the silica gel pad for detection.
The process of installing the blood purification line in the CVVHDF pre-dilution treatment mode may mainly include steps S610 to S650, which will be described in detail below.
It should be noted that, the sequence number of each step in the embodiment of the present application does not mean the sequence of execution sequence, and the execution sequence of each process should be determined by the function and the internal logic of each process, and should not limit the implementation process of the embodiment of the present application in any way.
In step S610, the line fixture 400 to which the common line module 110 is fixed is mounted on a panel of the blood purifying apparatus. It will be appreciated that the common line assembly 110 may be assembled in situ during treatment, and that the common line assembly 110 may also be pre-assembled and secured by the line fixture 400, which may help reduce treatment latency.
In step S620, the dialyzer connector 25 of the arterial line 111 is connected to the first blood chamber end (input) of the hemofilter 35.
In step S630, the dialyzer connector 25 of the venous line 112 is connected to the second blood chamber end (output end) of the hemofilter 35.
In step S640, the auxiliary line B (302) is mounted on the substitution pump of the blood purification apparatus, the male connector 18 at the input end thereof is connected to the female connector 17 on the first fluid-supplementing branch B1 of the fluid-supplementing line, and the male connector 18 at the output end thereof is connected to the three-way check valve 23 of the arterial line 111 (corresponding to the CVVHDF pre-dilution mode).
The male connector 18 (third output connector) at the output end of the fluid replacement line 113 is connected to the female connector 17 of the first auxiliary line I (621), the hansen connector 33 of the first auxiliary line I (621) is connected to the first side branch of the hemofilter 35, and the male connector 18 (i.e., third input connector) at the input end is connected to the replacement fluid bag 37.
In step S650, the male connector 18 (fourth input connector) at the input end of the filtrate line 114 is connected to the female connector 17 of the second auxiliary line I (622), the hansen connector 33 of the second auxiliary line I (622) is connected to the second side branch of the hemofilter 35, and the male connector 18 (fourth output connector) at the output end of the filtrate line 114 is connected to the waste liquid bag 36.
In fig. 6, the connection of the blood purification line, the filter, and the consumable in the CVVHDF pre-dilution treatment mode is completed. The flow direction of the liquid in each of the blood purification tubes 600 is indicated by the arrows in fig. 6.
Fig. 7 is a schematic diagram of another possible implementation of the blood purification circuit of fig. 1. As shown in fig. 7, the blood purification line 700 is suitable for use in a post-dilution treatment mode of continuous intravenous hemodiafiltration (CVVHDF). The blood purification circuit 700 may include: common line assembly 110, target auxiliary line assembly 620. The common line assembly 110 includes an arterial line 111, a venous line 112, a make-up line 113, and a filtrate line 114. The target auxiliary line assembly 620 includes 1 auxiliary line B, 2 auxiliary lines I, i.e., the target auxiliary line assembly 620 may include: auxiliary line B (302), first auxiliary line I (621), second auxiliary line I (622). The target filter for the CVVHDF treatment mode is hemofilter 35. In addition, the consumable that cooperation pipeline used still includes: a waste liquid bag 36 and a replacement liquid bag 37. The flow direction of the liquid in each of the blood purification tubes 700 is indicated by the arrows pointing in fig. 7.
The main difference between the CVVHDF post-dilution treatment mode and the CVVHDF pre-dilution treatment mode is: the auxiliary line B (302) is mounted on the substitution liquid pump of the blood purification apparatus, the male connector 18 at its input end is connected to the female connector 17 on the first fluid-supplementing branch B1 of the fluid-supplementing line, and the male connector 18 at its output end is connected to the three-way check valve 23 of the venous line 112 (corresponding to the CVVHDF postdilution mode). In the venous line 112, the venous three-way check valve 23 is connected to the male connector 18 at the output end of the auxiliary line B (302) due to the post-dilution of the substitution liquid, and the substitution liquid is introduced from the auxiliary line B (302) into the venous line 112 through this connection.
Fig. 8 is a schematic diagram of yet another possible implementation of the blood purification circuit of fig. 1. As shown in fig. 8, the blood purification circuit 800 is adapted for use in a treatment mode of double filtered plasmapheresis (DFPP). The blood purification circuit 800 may include: a common line assembly 110, a line fixture 400, and a target auxiliary line assembly 820. The common line assembly 110 includes an arterial line 111, a venous line 112, a make-up line 113, and a filtrate line 114. The target auxiliary line assembly 820 includes 1 auxiliary line A (301), 2 auxiliary lines G,1 auxiliary line I (309), 1 auxiliary line J (310). That is, the target auxiliary line assembly 820 may include: auxiliary line A (301), first auxiliary line G (821), second auxiliary line G (822), auxiliary line I (309), auxiliary line J (310). The target filters corresponding to DFPP treatment modes are a hemofilter 35 and a hemodialyzer 38. In addition, the consumable that cooperation pipeline used still includes: waste liquid bag 36, albumin bag 45. The flow direction of the liquid in each of the blood purification tubes 800 is indicated by the arrows pointing in fig. 8.
The process of installing DFPP the blood purification circuit 800 in the treatment mode may mainly include steps S810 to S860, which will be described in detail below.
In step S810, the line fixture 400 to which the common line module 110 is fixed is mounted on a panel of the blood purifying apparatus. The common line assembly 110 may be assembled in situ during treatment or may be pre-assembled and secured by the line fixture 400, which helps to reduce treatment latency.
In step S820, the dialyzer connector 25 of the arterial line 111 is connected to the first blood chamber end (input end) of the hemodialyzer 38.
In step S830, the dialyzer connector 25 of the venous line 112 is connected to the second blood chamber end (output end) of the hemodialyzer 38.
In step S840, the auxiliary line a (301) is attached to the substitution liquid pump of the blood purification apparatus, and the male connector 18 at the input end thereof is connected to the female connector 17 of the auxiliary line I (309), and the hansen connector 33 of the auxiliary line I (309) is connected to the side branch of the hemodialyzer 38. The male connector 18 at the output of the auxiliary line a (301) is connected to the female connector 17 of the first auxiliary line G (821), and then the hansen connector 33 of the first auxiliary line G (821) is connected to the first blood chamber end (input) of the hemofilter 35.
In step S850, the male connector 18 at the input of the filtrate line 114 is connected to the female connector 17 of the second auxiliary line G (822), and then the hansen connector 33 of the second auxiliary line G (822) is connected to the second blood chamber end (output) of the hemofilter 35. The male connector 18 at the output of the filtrate line 114 is connected to the reject bag 36.
In step S860, the male connector 18 of the auxiliary line J (310) is connected to the female connector 17 of the second fluid replacement branch B2 of the fluid replacement line, and then the hansen connector 33 of the auxiliary line J (310) is connected to the side branch of the hemofilter 35. The male connector 18 at the output end of the fluid infusion line 113 is connected with the three-way check valve 23 of the venous line 112, and the male connector 18 at the input end of the fluid infusion line 113 is connected with the albumin bag 45.
Thus, the connection and combination of the DFPP blood purification pipeline in the treatment mode and other consumable materials in the embodiment of the application are completed.
During treatment, if the CVVHDF treatment mode is required to be switched to DFPP treatment modes, the common line assembly 110 fixed by the line fixture 400 may remain unchanged, and only the target auxiliary line assembly 620 in fig. 6 needs to be replaced with the target auxiliary line assembly 820 in fig. 8, and then a corresponding target filter is connected. The target auxiliary line assembly 820 includes 1 auxiliary line a (301), 2 auxiliary lines G, 1 auxiliary line I (309), 1 auxiliary line J (310).
Fig. 9 is a schematic diagram of yet another possible implementation of the blood purification circuit of fig. 1. As shown in fig. 9, the blood purification line 900 is suitable for use in a treatment mode of a Molecular Adsorption Recirculation System (MARS). The blood purification circuit 900 may include: common line assembly 110, target auxiliary line assembly 920. The common line assembly 110 includes an arterial line 111, a venous line 112, a make-up line 113, and a filtrate line 114. The target auxiliary line assembly 920 includes 1 auxiliary line a (301), 1 auxiliary line C (303), 1 auxiliary line D (304), 1 auxiliary line F (306), 1 auxiliary line G (307), 4 auxiliary lines I. As shown in fig. 9, the target auxiliary line assembly 820 may include: auxiliary line a (301), auxiliary line C (303), auxiliary line D (304), auxiliary line F (306), auxiliary line G (307), first auxiliary line I (921), second auxiliary line I (922), third auxiliary line I (923), and fourth auxiliary line I (924). The target filters corresponding to the MARS treatment pattern are: a hemofilter 35, a hemodialyzer 38, a first adsorber 39 and a second adsorber 40. In addition, other consumables that cooperate with the pipeline to use still include: waste fluid bag 36, plasma bag 42. The flow direction of the liquid in each of the blood purification tubes 900 is indicated by the arrows in fig. 9.
The process of installing the blood purification tube 900 in the MARS treatment mode may mainly include steps S910 to S980, which will be described in detail below.
In step S910, the line fixture 400 to which the common line module 110 is fixed is mounted on a panel of the blood purifying apparatus. The common line assembly 110 may be assembled in situ during treatment or may be pre-assembled and secured by the line fixture 400, which helps to reduce treatment latency.
In step S920, the dialyzer connector 25 of the arterial line 111 is connected to the first blood chamber end (input end) of the hemodialyzer 38.
In step S930, the dialyzer connector 25 of the venous line 112 is connected to the second blood chamber end (output end) of the hemodialyzer 38.
In step S940, the auxiliary line a (301) is mounted on the substitution liquid pump of the blood purification apparatus, the male connector 18 at the input end thereof is connected to the female connector 17 of the first auxiliary line I (921), then the hansen connector 33 of the first auxiliary line I (921) is connected to the first side branch of the hemodialyzer 38, the male connector 18 at the output end of the auxiliary line a (301) is connected to the female connector 17 of the auxiliary line G (307), and then the hansen connector 33 of the auxiliary line G (307) is connected to the first blood chamber end (input end) of the hemofilter 35.
In step S950, the male connector 18 at the input end of the filtrate line 114 is connected to the female connector 17 of the second auxiliary line I (922), and then the hansen connector 33 of the second auxiliary line I (922) is connected to the first side branch of the hemodialyzer 35, and the male connector 18 at the output end is connected to the waste liquid bag 36.
In step S960, the male connector 18 at the output end of the fluid replacement line 113 is connected to the female connector 17 of the third auxiliary line I (923), and then the hansen connector 33 of the third auxiliary line I (923) is connected to the second side branch of the hemodialysis machine 35. The male connector 18 of the input is connected to a plasma bag 42.
In step S970, the dialyzer connection 25 at one end of the auxiliary line D (304) is connected to the second blood chamber end (output end) of the hemofilter (35), and the dialyzer connection 25 at the other end of the auxiliary line D (304) is connected to the input end of the first adsorber 39.
In step S980, the dialyzer joint 25 at one end of the auxiliary line C (303) is connected to the output end of the first adsorber 39, and the dialyzer joint 25 at the other end of the auxiliary line C (303) is connected to the input joint of the second adsorber 40.
In step S990, the dialyzer connection 25 of the auxiliary line F (306) is connected to the outlet connection of the second adsorber 40, the first male connection 18 of the auxiliary line F (306) is connected to the female connection 17 of the fourth auxiliary line I (924), and the hansen connection 33 of the fourth auxiliary line I (924) is connected to the second side branch of the hemodialyzer 38.
Thus, the connection and combination of the blood purifying pipeline and other consumable materials in the MARS treatment mode in the embodiment of the application are completed.
During treatment, if DFPP treatment mode is required to be switched to MARS treatment mode, the common line assembly 110 fixed to the line fixture 400 may remain unchanged, and only the target auxiliary line assembly 820 of FIG. 8 is required to be replaced with the target auxiliary line assembly 920 of FIG. 9, and then the corresponding target filter is connected. The target auxiliary line assembly 920 includes 1 auxiliary line a (301), 1 auxiliary line C (303), 1 auxiliary line D (304), 1 auxiliary line F (306), 1 auxiliary line G (307), and 4 auxiliary lines I.
It can be seen that due to the existence of the common line assembly 110, the medical staff can rapidly and accurately install the arterial line, the venous line, the fluid infusion line and the filtrate line, which are needed to be used, at the corresponding positions of the blood purifying apparatus, without separately installing each tube (or installing each tube). In the embodiment of the application, the public pipeline component is arranged on the pipeline fixing device, the trend of the pipeline is clear and visual, the operation steps and the connection time of medical staff are reduced, and the risk of pipeline connection errors is reduced.
Embodiments of the present application provide a medical device that may include a blood purification circuit as described in any of the foregoing. The medical device may be, for example, a blood purification device.
An embodiment of the apparatus of the present application is described above in detail in connection with fig. 1 to 9, and an embodiment of the method of the present application is described below in detail in connection with fig. 10. It is to be understood that the description of the method embodiments corresponds to the description of the device embodiments, and that parts not described in detail can therefore be seen in the preceding device embodiments.
Fig. 10 is a flow chart of a method for connecting a blood purification line according to an embodiment of the present application. As shown in fig. 10, the method of connecting the blood purification tube may mainly include steps S1010 to S1020, which will be described in detail below.
It should be noted that, the sequence number of each step in the embodiment of the present application does not mean the sequence of execution sequence, and the execution sequence of each process should be determined by the function and the internal logic of each process, and should not limit the implementation process of the embodiment of the present application in any way.
In step S1010, a utility line assembly is connected. The common line assembly includes an arterial line, a venous line, a fluid replacement line, and a filtrate line, and is adapted for use in any one of a plurality of treatment modes.
In step S1010, the common line assembly and the target filter are connected by the target auxiliary line assembly to form a continuous blood purifying line suitable for the target treatment mode. The target filter comprises one or more filters.
The arterial pipeline is provided with a first input connector and a first output connector, the first input connector is connected with an arterial puncture needle on a patient, and the first output connector is connected with a target filter. The venous line is provided with a second input connector and a second output connector, the second input connector is connected with the target filter, and the second output connector is connected with a venous puncture needle on the patient. The fluid infusion pipeline is provided with a third input connector and a third output connector, and the third input connector is connected with the fluid infusion container. The filtrate pipeline is provided with a fourth input connector and a fourth output connector, and the fourth output connector is connected with the waste liquid container.
Optionally, the target auxiliary line assembly is comprised of one or more auxiliary lines, the plurality of auxiliary lines being of the same or different type.
Optionally, any of the one or more auxiliary lines is composed of at least a part of the following elements: female joint, male joint, dialysis joint, T-shaped three-way joint, Y-shaped three-way joint, body, liquid pump pipe clamp, pump pipe, plasma pot, hansen joint, pressure measuring branch pipe, fluid supplementing branch pipe. The pressure measuring branch pipe is used for detecting pressure, and the fluid supplementing branch pipe is used for supplementing fluid.
Optionally, the pressure manifold includes a sensor protector and a female connector, and the fluid replacement manifold includes a female connector.
Optionally, the first output connector and the second input connector are dialysis connectors, and the third output connector and the fourth input connector are male connectors.
Optionally, the target filter comprises part or all of a hemofilter, a hemodialyzer, a plasma separator, a perfusion, an adsorber.
Optionally, the plurality of treatment modes includes at least some or all of the following treatment modes: slow Continuous Ultrafiltration (SCUF), continuous intravenous-venous hemofiltration (CVVH), continuous intravenous-venous hemodiafiltration (CVVHDF), continuous intravenous-venous hemodialysis (CVVHD), double filtration plasmapheresis (DFPP), plasma Adsorption (PA), plasmafiltration (PDF), double Plasma Molecular Adsorption System (DPMAS), paired plasmafiltration adsorption (CPFA), hemodiafiltration (HP), repeated Albumin Dialysis (RAD), single albumin pass dialysis (SPAD), molecular Adsorption Recirculation System (MARS), plasmapheresis (PE), plasma Separation Adsorption System (PSAS).
In describing embodiments of the present application, it should be understood that the terms "first," "second," and "second" are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or number of features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the embodiments of the present application, the meaning of "plurality" is at least two, for example, two, three, etc., unless explicitly defined otherwise.
It should be noted that in the embodiments of the present application, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
In describing embodiments of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application.
In the embodiments of the present application, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured" and the like are to be construed broadly and include, for example, either permanently connected, removably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art according to the specific circumstances.
It should be understood that the term "and/or" used in the embodiments of the present application is merely an association relationship describing the association object, and indicates that three relationships may exist, for example, a and/or B may indicate: a exists alone, A and B exist together, and B exists alone. In addition, the character "/" in the embodiment of the present application generally indicates that the front and rear association objects are in an or relationship.
In the description of embodiments of the present application, a description of reference to the terms "one embodiment," "some embodiments," "examples," "particular examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present application. In describing embodiments of the present application, the schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.
The foregoing is merely illustrative of the present application, and the present application is not limited thereto, and any person skilled in the art will readily recognize that variations or substitutions are within the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (22)
1. A blood purification circuit, comprising:
a common line assembly comprising an arterial line, a venous line, a fluid replacement line, and a filtrate line, the common line assembly adapted for use in any one of a plurality of treatment modes;
A target auxiliary line assembly for connecting the common line assembly and a target filter such that the blood purification line is a continuous line suitable for a target treatment mode, the target filter comprising one or more filters;
The arterial line is provided with first input joint and first output joint, first input joint is connected with the arterial puncture needle on one's body of patient, first output joint with the target filter is connected, venous line is provided with second input joint and second output joint, the second input joint with the target filter is connected, the second output joint with the venous puncture needle on one's body of patient is connected, the fluid replacement line is provided with third input joint and third output joint, third input joint is connected with the fluid replacement container, the filtrate line is provided with fourth input joint and fourth output joint, fourth output joint is connected with the waste liquid container.
2. The blood purification circuit of claim 1, wherein the target auxiliary circuit assembly is comprised of one or more auxiliary circuits of the same or different types.
3. A blood purification circuit according to claim 2, wherein any of the one or more auxiliary circuits is composed of at least some of the following elements, the fittings of the elements making up any auxiliary circuit being matched:
Female joint, public joint, dialysis joint, T type three way connection, Y type three way connection, body, liquid pump pipe clamp, pump line, plasma kettle, hansen joint, pressure measurement branch pipe, fluid replacement branch pipe, wherein pressure measurement branch pipe is used for detecting pressure, fluid replacement branch pipe is used for replenishing liquid.
4. A blood purification circuit according to claim 3, wherein the pressure manifold comprises a sensor protector and the female connector, and the fluid replacement manifold comprises the female connector.
5. The blood purification circuit of claim 1, wherein the first output connector and the second input connector are dialysis connectors and the third output connector and the fourth input connector are male connectors.
6. The blood purification circuit of claim 1, wherein the target filter comprises a portion or all of a hemofilter, a hemodialyzer, a plasma separator, a perfusion, an adsorber.
7. The blood purification circuit of any one of claims 1-6, wherein the plurality of treatment modes includes at least some or all of the following treatment modes:
Slow continuous ultrafiltration SCUF, continuous intravenous-venous hemofiltration CVVH, continuous intravenous-venous hemodiafiltration CVVHDF, continuous intravenous-venous hemodialysis CVVHD, double filtration plasmapheresis DFPP, plasmafiltration PA, plasmafiltration PDF, double plasma molecular adsorption system DPMAS, paired plasmafiltration adsorption CPFA, hemoperfusion HP, repeated albumin dialysis RAD, single albumin pass dialysis SPAD, molecular adsorption recirculation system MARS, plasmapheresis PE, plasmafiltration adsorption system PSAS.
8. A line securement device for securing a utility line assembly in a blood purification line, the utility line assembly comprising an arterial line, a venous line, a fluid replacement line, and a filtrate line, the utility line assembly adapted for use in any one of a plurality of treatment modes, the line securement device comprising:
the mounting plate is mounted on the front face of the blood purification device corresponding to the blood purification pipeline, and is provided with a plurality of through holes which are matched with a plurality of pumps of the blood purification device so as to expose the pumps;
A plurality of tube clamps located on one side of the mounting plate, a portion of the plurality of tube clamps being arranged in a first direction of the mounting plate, another portion of the plurality of tube clamps being arranged in a second direction, the plurality of tube clamps being configured to secure a tube body in the utility line assembly in the first direction, the second direction, respectively, the first direction being different from the second direction;
Wherein the blood purification line further comprises a target auxiliary line assembly for connecting the common line assembly and a target filter such that the blood purification line is a continuous line suitable for a target treatment mode, the target filter comprising one or more filters.
9. The plumbing fixture of claim 8, wherein a portion of the plurality of through holes is configured to expose one or more of:
Venous pot clamp, venous clamp, bubble monitoring element in the blood purification device.
10. The line fixture of claim 9, wherein the plurality of pumps comprises a blood pump, a first liquid pump, a second liquid pump, and a filtrate pump, the plurality of through-holes comprising, viewed in a direction perpendicular to a front face of the blood purification apparatus:
The first through hole is positioned at the upper right of the mounting plate and used for exposing the blood pump; and/or the number of the groups of groups,
The second through hole is positioned at the upper left of the mounting plate and used for exposing the second liquid pump; and/or the number of the groups of groups,
The third through hole is positioned at the left lower part of the mounting plate and used for exposing the first liquid pump; and/or the number of the groups of groups,
The fourth through hole is positioned at the right lower part of the mounting plate and used for exposing the filtrate pump; and/or the number of the groups of groups,
And the fifth through hole is positioned at the left side of the first through hole and used for exposing the venous kettle clamp.
11. The line fixture of claim 8, wherein the tube clamp is an elastic tube clamp having a recess for receiving the tube, the elastic tube clamp having an opening for the tube to be snapped in or pulled out.
12. The plumbing fixture of claim 8, wherein the mounting plate is a flat plate and/or the mounting plate is a transparent plate.
13. The line fixture of claim 8, wherein the connection between the mounting plate and the blood purification apparatus is any one of:
bonding, buckling and hanging.
14. The line fixture of claim 13, wherein when the connection between the mounting plate and the blood purification apparatus is in a hanging manner, the line fixture comprises:
the hanging buckles are arranged at the top of the second side of the mounting plate, the second side is opposite to the mounting side of the pipe clamps, and the hanging buckles are respectively connected with the hooks arranged on the blood purifying device.
15. The line fixture of claim 8, wherein the plurality of tube clamps are integrally formed with the mounting plate.
16. The line fixture of claim 15, wherein the plurality of tube clamps are formed by means of a plastic suction molding.
17. The pipe fixing device according to claim 8, wherein the plurality of pipe clamps are fixed to the mounting plate in any one of the following manners:
bonding, bolting and sliding clamping.
18. The line fixture of any one of claims 8-17, wherein the first direction is a horizontal direction and the second direction is a vertical direction.
19. The line fixture of any one of claims 8-17, wherein the plurality of treatment modes includes at least some or all of the following treatment modes:
Slow continuous ultrafiltration SCUF, continuous intravenous-venous hemofiltration CVVH, continuous intravenous-venous hemodiafiltration CVVHDF, continuous intravenous-venous hemodialysis CVVHD, double filtration plasmapheresis DFPP, plasmafiltration PA, plasmafiltration PDF, double plasma molecular adsorption system DPMAS, paired plasmafiltration adsorption CFPA, hemoperfusion HP, repeated albumin dialysis RAD, single albumin pass dialysis SPAD, molecular adsorption recirculation system MARS, plasmapheresis PE, plasmafiltration adsorption system PSAS.
20. A method of connecting a blood purification circuit, comprising:
Connecting a common line assembly comprising an arterial line, a venous line, a fluid replacement line, and a filtrate line, the common line assembly adapted for use in any one of a plurality of treatment modes;
Connecting the common line assembly and a target filter using a target auxiliary line assembly to form a continuous blood purification line suitable for a target treatment mode, the target filter comprising one or more filters;
The arterial line is provided with first input joint and first output joint, first input joint is connected with the arterial puncture needle on one's body of patient, first output joint with the target filter is connected, venous line is provided with second input joint and second output joint, the second input joint with the target filter is connected, the second output joint with the venous puncture needle on one's body of patient is connected, the fluid replacement line is provided with third input joint and third output joint, third input joint is connected with the fluid replacement container, the filtrate line is provided with fourth input joint and fourth output joint, fourth output joint is connected with the waste liquid container.
21. The method of claim 20, wherein the target auxiliary line assembly is comprised of one or more auxiliary lines, the plurality of auxiliary lines being of the same or different type.
22. The method of any one of claims 20-21, wherein the plurality of treatment modes are some or all of the following treatment modes:
Slow continuous ultrafiltration SCUF, continuous intravenous-venous hemofiltration CVVH, continuous intravenous-venous hemodiafiltration CVVHDF, continuous intravenous-venous hemodialysis CVVHD, double filtration plasmapheresis DFPP, plasmafiltration PA, plasmafiltration PDF, double plasma molecular adsorption system DPMAS, paired plasmafiltration adsorption CPFA, hemoperfusion HP, repeated albumin dialysis RAD, single albumin pass dialysis SPAD, molecular adsorption recirculation system MARS, plasmapheresis PE, plasmafiltration adsorption system PSAS.
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| Publication Number | Publication Date |
|---|---|
| CN118304508A true CN118304508A (en) | 2024-07-09 |
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