CN1182857C - Use of compound prescription of pollen and Chinese medicine in preparing medicine for enhancing motor ability - Google Patents
Use of compound prescription of pollen and Chinese medicine in preparing medicine for enhancing motor ability Download PDFInfo
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- CN1182857C CN1182857C CNB021311781A CN02131178A CN1182857C CN 1182857 C CN1182857 C CN 1182857C CN B021311781 A CNB021311781 A CN B021311781A CN 02131178 A CN02131178 A CN 02131178A CN 1182857 C CN1182857 C CN 1182857C
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Abstract
The present invention relates to the use of compound prescription of pollen and traditional Chinese medicine in preparing a medicine for enhancing sports ability. The active ingredients of the compound prescription of pollen and traditional Chinese medicine of the present invention are the extracts of pollen and traditional Chinese medicine. The pollen is cattail pollen and honey source pollen, and the other ingredients are pharmacologically acceptable adjuvants and excipients. Through pharmacodynamics study on animals, tests and study on a human body and the tests of acute toxicity and chronic toxicity, the compound prescription of pollen and traditional Chinese medicine of the present invention has functions of increasing sports ability, and has no toxic or side effect.
Description
Technical field:
The present invention relates to a kind of Chinese medicine compound that contains pollen that improves motor capacity.
Background technology:
Pollen just has been listed in the important drugs of health preserving tonification since ancient times, ancient Greek and the Egyptian pollen that claims are youth and healthy source.Also be considered as the anti-ageing good merchantable brand of health preserving modern age, be used for defying age, beauty treatment etc. as the nutritional supplement.Chinese patent (application number 93107563) discloses a kind of ginseng and astragalus root pollen preparation, contains Radix Codonopsis, the Radix Astragali, Pollen Typhae, Pollen Brassicae campestris, Pollen Maydis and Pollen Helianthi, is used to improve body anoxia tolerance and opposing aging.
Summary of the invention:
The technical problem to be solved in the present invention provides the new purposes of the Chinese medicine compound that contains pollen, i.e. application in preparation raising motor capacity medicine.
Pollen Chinese medicine compound of the present invention is: 4 parts of pollen, and 1 part of Radix Codonopsis fluid extract, 1 part of Radix Astragali fluid extract, other composition are acceptable adjuvant of medicine and excipient, above-mentioned umber is weight portion.
Described pollen is natural pollen and one or more Pollen Preparationses.
Described natural pollen is a Pollen Typhae, and described Pollen Preparations comprises the pollen of Cortex Sapii Radicis, Radix Codonopsis, Semen Viciae fabae, Semen Fagopyri Esculenti, Cotton Gossypii, Brassica campestris L, Helianthi, corn etc.
Described pollen is Pollen Typhae and Cortex Sapii Radicis pollen preferably, and Pollen Typhae and Cortex Sapii Radicis pollen consumption such as are at weight.
Pollen Chinese medicine compound of the present invention can be with any medicine acceptable carrier as adjuvant, and can be made into various peroral dosage forms, as tablet, granule, mastic, oral liquid etc.
The preparation method of pollen Chinese medicine compound of the present invention is as follows:
1. the preparation of Chinese medicine fluid extract
Take by weighing the high-quality crude drug in whole, discharge water and feed steam to medicinal residues and seethe with excitement, kept one hour, collect medicinal residues, concentrate.The drying under reduced pressure concentrate is pulverized the medicine concentrate, sieves, and seals standby.
2. the pretreatment of pollen:
Pollen is dried moisture, and it is standby to make powdery with pulverizer.
3. combine with the Chinese medicine fluid extract with through the acceptable adjuvant of pretreated pollen and medicine, excipient, make preparation.
The example that is prepared as with coated tablet:
Powdered flower grain is added 1% sodium carboxymethyl cellulose (CMC) aqueous solution,, place baking box with drawing together a machine by the 12-14 mesh sieve.At 70 ℃ of following drying under reduced pressure, by 14 mesh sieves,, add the 5-10% microcrystalline cellulose with Chinese medicine fluid extract granule mixing, 0.5% magnesium stearate, the 0.5-10% Pulvis Talci is mixed thoroughly, sieves tabletting.Carry out coating then, to guarantee the curative effect and the steady quality of tablet.Coating was divided into for three steps: 1, label packs secondary with natural gum slurry, mixed powder.2, with pure gelatin syrup, mixed powder packs.3, colouring, polishing.
In order to understand essence of the present invention better, will in the pharmacological evaluation and the result of animal and human's body its new purposes in pharmaceutical field be described with the Chinese medicine compound that contains pollen below.
Confirm that through pharmacodynamic study and acute and chronic toxicity test pollen Chinese medicine compound of the present invention is without any side effects, and tool improves the motor capacity effect.Carry out branch experimentation and two aspects of human body checking, the motion model that experimentation adopts is swimming, animal is used for adopting when integral level is observed Shanghai kind white mice, body weight 20 ± 2g observes biochemical indicator and adopts pure AMS/5L mice, and route of administration is an administration by gavage, test beginning administration in preceding 3 days, promptly begin swimming test behind experiment administration on the same day 2h, dosage is 0.2ml/ only (0.25g/ml), and contrast replaces with the equivalent distilled water.The swimming water temperature is 31～33 ℃, and swimming time is 90～120mm.Zoopery confirms that medicine of the present invention can obviously improve the mice swimming time; Significantly increase the 17-hydroxy-11-dehydrocorticosterone secretory volume; Increase SOD content in the heart, liver, the lung; Significantly lactic acid content makes it recover normal in the reduction blood.
The human body checking is undertaken by the Tianjin Research Institute of Physical Culture " the tired removing method of dynamic exercise seminar " cooperation, and identifying object is a Tianjin motion school, and Tianjin swimming center teenager (10～15 years old) student is totally 30 people (12 of 18 woman of man).
The effect of taking from the athlete sees and can improve athletic heart's function that special performance has clear improvement to myocardial compliance and conduction function, and the adaptive capacity of load exercise is played a role.
Pollen Chinese medicine compound of the present invention can also obviously be improved symptoms such as dizziness that reasons such as the modern is big because of pressure, environmental pollution occur, uncomfortable in chest, dyspnea, malaise.
The specific embodiment:
Following examples only for the present invention is described, do not limit the invention.
The preparation of embodiment 1 pollen compound preparation
1. the preparation of Chinese medicine fluid extract
The preparation method of Radix Codonopsis fluid extract is: take by weighing high-quality Radix Codonopsis crude drug in whole, put in the steam pot jacketed pan, discharge water about 10 times and feed steam to the medicinal residues boiling, kept one hour, collect medicinal residues.Three times so repeatedly.With the medicinal residues process thin film concentration of collecting, medicinal residues are concentrated into 15: 1 concentration again.Carry out drying under reduced pressure after concentrating.Concrete grammar is: the medicinal residues that will concentrate are placed in the stainless steel disc, (vacuum is 760mmhg) drying under vacuum condition, and temperature is controlled at below 80 ℃, and the time is 12-24 hour.Take out dry good medicine and pack in the plastic tape airtight preservation immediately into.At last, pulverize dry drug and, seal standby with pulverizer by 14 mesh sieves.
The preparation method of Radix Astragali fluid extract is the same.Weight such as Radix Codonopsis fluid extract and Radix Astragali fluid extract consumption are.
2. pollen pretreatment
With Pollen Typhae pollen and Cortex Sapii Radicis pollen oven dry moisture, by etc. weight to be ground into powdery with pulverizer standby.
3. preparation preparation
With powdered pollen and Chinese medical concrete ginseng stilbene granule mixing, consumption is: 2 parts of pollen, 1 part of Chinese medical concrete.Add the 5-10% microcrystalline cellulose, 0.5% magnesium stearate, the 0.5-10% Pulvis Talci is mixed thoroughly, crosses 14 mesh sieves, gets final product tabletting.With 12m/m sugar-coat punch die direct compression.
4. coating
Be divided into for three steps: 1, label packs secondary with natural gum slurry, mixed powder, each dry about 45 minutes.2, with pure gelatin syrup, it heavily is about 0.65 gram that mixed powder packs sheet.3, the toner clothing is arranged with serge blue and lemon yellow, coloured syrup from the superficial to the deep, it heavily is about 0.78 gram that the mixed powder sheet packs sugarcoating layer to sheet, gets final product polishing.
5. pack
Embodiment 2 improves motor capacity animal pharmacology experimentation
(1) integral level is observed the healthy adult mice in 31～33 ℃ of swimming down of water temperature, and animal needs elder generation through screening, and to dwindle the individual variation of swimming skills, laboratory animal is divided into three groups at random, i.e. matched group, pollen and pollen compound recipe group.Experimental result is listed in table 1.
The influence of table 1 pair swimming mice time-to-live
Average mean survival time P value
Blank group 152 154.5 ± 18.5
Pollen group 154 175.6 ± 21.4 0.01
Pollen compound recipe group 154 186.5 ± 28.8 0.001
Annotate: the P value all with the contrast ratio income value
As seen from Table 1, pollen and pollen compound recipe all can improve the mice swimming time by highly significant, and it is higher that the two compares pollen compound recipe efficient.
(2) to swimming mouse red blood cell film Na
+-K
+-ATP enzyme and Mg
++-ATP enzyme activity influence Na
+-K
+-ATP enzyme and Mg
++-ATP enzyme is present on the cell membrane, and is closely related with anakinetomer catabolism.These two kinds of enzyme activities on the anoxia animal brain cortical cell film are observed, and enzyme activity significantly increases when seeing anoxia, and anti-anoxic medicine can make enzyme activity return to normal level.
Observed Na on the swimming mouse red blood cell film
+-K
+-ATP enzyme and Mg
++-ATP enzyme activity variation, reduce slightly when the result swims, with ging up again behind the pollen, but equal no statistical significances.Same parallel observations the influence of pollen compound recipe to these two kinds of enzyme activities, can find out that the pollen compound recipe gos up this two enzyme to some extent.The results are shown in table 2.
Table 2 couple swimming mouse red blood cell film Na
+-K
+-ATP enzyme and Mg
++The influence of-ATP enzyme activity (μ g/mg albumen/h)
Number of animals Na
+-K
+-enzyme Mg
++-ATP enzyme
Normal control 10 3.10 ± 1.29 6.64 ± 3.03
Swimming contrast 10 2.71 ± 1.48 5.54 ± 2.03
Pollen swims 10 3.57 ± 1.16 7.03 ± 4.12
The pollen compound recipe swims 10 3.82 ± 1.31 7.25 ± 2.01
(3) to the influence of swimming mice adrenocortical hormone content
Adrenal cortex alcohol and corticosterone belong to glucocorticoid, the variation in their the variation reflection body on some physiological function and the substance metabolism, and they occupy critical role in physical stress.Body is under a kind of stress state, causes that the 17-hydroxy-11-dehydrocorticosterone secretion increases during swimming.Variation when having observed mice swimming behind adrenocortical hormone secretion situation and the clothes pollen compound recipe.Assay method is a radioimmunology, the results are shown in table 3.
As seen from Table 3, corticosterone content is 70 times of hydrocortisone content, and visible mice adrenal gland glucocorticoid is based on corticosterone.
The influence of table 3 pair swimming mice plasma 17-hydroxy-11-dehydrocorticosterone content
Number of animals hydrocortisone (μ g/dl) corticosterone (μ g/dl)
The mice blank group 8 0.147 ± 0.209 29.250 ± 20.048 of not swimming
Swimming mice blank group 9 0.604 ± 0.121
*39.440 ± 18.172
The swimming mice is taken medicine and organizes 10 0.596 ± 0.101
*54.444 ± 11.226
Annotate:
*With normal pressure than difference highly significant,
*More remarkable than difference with normal pressure, Δ is more approaching significantly than difference with anoxia, and T value is 1.986
By the eyeball blood-letting, the result finds out that blood plasma cortisol content increases highly significant behind the mice swimming 90min, clothes pollen compound recipe animal increases also remarkable, but do not have significant difference with the swimming contrast ratio, in corticosterone when swimming, also increase to some extent, but with normal control than no significant difference.The animal corticosterone content of clothes pollen compound recipe is significantly than normal control group height, and is also significantly approaching with swimming contrast ratio difference.
Conclusion: the pollen compound recipe can obviously improve the mice swimming time; Significantly increase the 17-hydroxy-11-dehydrocorticosterone secretory volume;
(4) to the influence of superoxide dismutase (SOD) content in swimming mouse core, liver, the lung tissue
SOD extensively is present in the aerobe object; it can control superoxides radical cation concentration in the cell; the protection cell is avoided the superoxides radical cation and is destroyed, and the biosynthetic speed of SOD is to be directly proportional with the concentration of superoxides radical cation in the cell.This experiment is main understands swimming to the influence of SOD content in mouse core, liver, the lung tissue and with the variation behind the pollen compound recipe, assay method polarography.The results are shown in table 4.
The influence (μ g/g weight in wet base tissue) of SOD content in table 4 pair swimming mouse core, liver, the lung tissue
| Group number of animals conscience lung |
| The mouse blank group of not swimming 10 1920.47 ± 122.47 155.19 ± 176.21 1602.43 ± 182.54 swimming mouse blank groups 10 1925.52 ± 165.39 1038.70 ± 120.37 1221.94 ± 172.73 swimming mouse are taken medicine and organize 10 2006.44 ± 169.63 1168.59 ± 138.84 1309.46 ± 154.53 |
As seen from Table 4, it is little to SOD content influence in mouse core, liver, the lung tissue to swim, though swimming is to the no statistical significance that decreases of SOD in liver and the lung.The pollen compound recipe can obviously increase SOD content in mouse core, liver, the lung.
(5) to the influence of glutathion (GSH) and the super oxidase of glutathion (GSHP-X) content in the swimming mice blood
The effect of GSHP-X is to utilize the reducing power of GSH that peroxide in the body is played Detoxication; it has great role to the detoxification of biological tissue peroxide; peroxide can be reduced into nontoxic hydroxy compounds and water; in order to avoid they are decomposed to form the HO and the RO of high reaction; relaunch peroxidization, the protection cell membrane is avoided destroying.We have observed white mice and have swum in 31～33 ℃ of water temperatures behind the 90min, the influence of GSH and GSHP-X content in the mouse blood, and the results are shown in Table 5.As seen from Table 5, during swimming in the blood GSH content increase GSHP-X and reduce, show that enzyme activity reduces, GSHP-X changes not obviously in the animal blood of clothes pollen compound recipe, and GSH concentration highly significant descends.
The influence (mg/dl) of GSHP-X content in the table 5 pair swimming mice blood
Number of animals GSHP-X GSH
Normal control 13 0.284 ± 0.133 27.95 ± 10.75
Swimming contrast 9 0.204 ± 0.149 37.00 ± 21.29
The pollen compound recipe swims 10 0.205 ± 0.107 20.14 ± 8.24
*
Annotate:
*With swimming contrast ratio difference highly significant
(6) to the influence of lactic acid content in swimming mouse blood and the muscle
Lactic acid is a very important index in training research, and it is relevant with the muscular tissue anoxia just to think that lactic acid generates 1920's, thinks that lactic acid is sugared anaerobic metabolism product.Though some change of notion that lactic acid is generated in recent years produces lactic acid and is still generally acknowledged by everybody after the muscular tissue anoxia.Anoxia mice blood lactic acid significantly increases.Muscle lactic acid also has the trend of increase, but statistics is not remarkable.Blood lactic acid is the sarcolactic acid transhipment, and it is very fast that lactic acid sees through muscle cell membrane speed, raises clearly so record lactic acid behind the anoxia 1h.The pollen compound recipe to motion when (swimming) influence of lactic acid content see Table 5.
Table 6 pollen compound recipe is to the influence of lactic acid content in swimming mouse blood and the muscle
Number of animals blood lactic acid (mg/dl) muscle lactic acid (mg/dl)
Normal control 10 53.08 ± 15.49 4.40 ± 0.79
Swimming contrast 10 70.52 ± 34.67
Δ4.94 ± 2.38
Pollen swims 10 50.02 ± 21.63
*3.34 ± 0.41
The pollen compound recipe swims 10 48.68 ± 23.99
*3.94 ± 1.60
Annotate:
*It is not remarkable with normal ratio,
*With swimming contrast ratio significant difference
As seen from Table 6, when swimming blood lactic acid increase significantly, the pollen compound recipe can prevent that the lactic acid increase returns to normal level when swimming.Muscle lactic acid changes with blood lactic acid same trend.
Embodiment 3 improves the checking of motor capacity human body
(1) object of observation: experimental subject is Tianjin sports school and 10～15 years old totally 30 of teenager student (12 of 18 woman of man) of Tianjin swimming center.
(2) observation index:
1, ultrasoundcardiogram: select peripheral fiber LVFS (Vef) for use, little axle LVFS (AD%) is penetrated blood system value (EF%), left ventricular ejection time (CVET) and stroke volume (SV), and Left ventricular posterior wall thickness (PWE).The full fast rate indexs such as (R/PWE) of fast full amplitude (R), left chamber, the contractile function pumping function and the diastolic function of observation heart.
2, electrocardiogram: mainly observe heart rate (HR) and myocardial ischemia and sexually revise (ST-T) etc.
3, light reaction time of action, the main observation moved incubation period etc.
4, flicker fusion threshold: observing bright with the inversion method is 1/2,1/8 HONGGUANG than degree, the different visuals field of 1/2 gold-tinted and 1/8 green glow parameter.
(3) method of administration: carry out the mensuration of above physical signs foundation level before taking medicine, take medicine then, take medicine 12 every day, divide clothes 2 times, each 6, the 1h clothes remake the preceding physiological index determining of taking medicine to estimate the effect of medicine down after taking medicine continuously 3 months after meal.
(4) observed result:
1, the correction uneven to mobility's sinus rate
Uneven person 7 people of resting heart rate before 30 experimenter's electrocardiogram findings are taken medicine account for total number of persons 23.3%, and the back no one that takes medicine reappears premature beat, arrhythmia, and the correction rate reaches 100%.
2, to the improvement of cardiac diastolic function
By observing in 30 experimenter's ultrasoundcardiograms, before and after taking medicine in the ultrasoundcardiogram fast full amplitude (R) and fast full rate (R/PWE) part be improved, statistical remarkable meaning is arranged, penetrate blood system value (EF%) and also significantly improve, visible medicine has more significantly improvement to cardiac diastolic function.
In addition, take medicine from the individual before and after stroke volume (SV), stroke volume increases before taking medicine after taking medicine, indivedual increase rates are bigger, illustrate that medicine also increases to cardiac systolic function.
The every index of table 7 ultrasound cardiogram
R PWE R/PWE ∠VET Vef ΔD％ EF％ SV
Difference meansigma methods 0.90 0.57 4.71 3.81 2.38 0.35 5.22 5.20
Standard error SD 1.55 1.83 9.81 3.01 0.21 2.73 10.18 15.92
Two averages differ standard error 0.34 0.40 1.92 6.56 4.52 0.60 2.22 3.48
T value 2.68
*1.43 2.45
*0.58 0.53 0.58 2.35
*1.50
Annotate:
*Has the significance difference
3, to central nervous system's influence
Find out that from flicker fusion and movement response time two fingers the frequency of flicker fusion threshold increased before and after most subjects was taken medicine, action shortening incubation period, the central nervous system has the trend that function is improved.
Brief summary:
Comprehensive Experiment research and human body checking find out that the pollen compound recipe has more significantly effect to improving the body movement ability.Find out that from experimentation the pollen compound recipe can significantly improve the mice swimming time; Improve hydrocortisone and corticosterone content; Improve superoxide dismutase content in the liver lung, reduce lactic acid content in the blood, make it return to normal level.Find out in the anthroposcopy that the pollen compound recipe can improve athletic heart's function, show that especially myocardial compliance and heart conduction function have significant improvement.Improve the adaptive capacity of athlete, certain meaning is arranged improving sports level to certain load exercise.Central nervous system function also there is certain improvement.
Claims (4)
1. a medicine that improves motor capacity mainly comprises: 4 parts of pollen, 1 part of Radix Codonopsis fluid extract, 1 part of Radix Astragali fluid extract; Other composition is acceptable adjuvant of medicine and excipient; Above-mentioned umber is weight portion.
2, the medicine of the described raising motor capacity of claim 1, it is characterized by described pollen is natural pollen and one or more Pollen Preparationses.
3, the medicine of the described raising motor capacity of claim 2, it is characterized by described natural pollen is Pollen Typhae.
4, the medicine of the described raising motor capacity of claim 1 is characterized by the Pollen Typhae and the Cortex Sapii Radicis pollen of weight such as described pollen is.
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|---|---|---|---|
| CNB021311781A CN1182857C (en) | 2002-10-15 | 2002-10-15 | Use of compound prescription of pollen and Chinese medicine in preparing medicine for enhancing motor ability |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021311781A CN1182857C (en) | 2002-10-15 | 2002-10-15 | Use of compound prescription of pollen and Chinese medicine in preparing medicine for enhancing motor ability |
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|---|---|
| CN1401364A CN1401364A (en) | 2003-03-12 |
| CN1182857C true CN1182857C (en) | 2005-01-05 |
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