CN118259036A - Full-automatic chemiluminescence immunoassay instrument - Google Patents
Full-automatic chemiluminescence immunoassay instrument Download PDFInfo
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- CN118259036A CN118259036A CN202410400593.4A CN202410400593A CN118259036A CN 118259036 A CN118259036 A CN 118259036A CN 202410400593 A CN202410400593 A CN 202410400593A CN 118259036 A CN118259036 A CN 118259036A
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- 238000003018 immunoassay Methods 0.000 title claims abstract description 52
- 238000006243 chemical reaction Methods 0.000 claims abstract description 306
- 238000001514 detection method Methods 0.000 claims abstract description 81
- 238000011534 incubation Methods 0.000 claims abstract description 42
- 238000011068 loading method Methods 0.000 claims abstract description 26
- 238000010517 secondary reaction Methods 0.000 claims abstract description 17
- 238000002347 injection Methods 0.000 claims abstract description 11
- 239000007924 injection Substances 0.000 claims abstract description 11
- 239000000523 sample Substances 0.000 claims description 304
- 239000007788 liquid Substances 0.000 claims description 263
- 239000003153 chemical reaction reagent Substances 0.000 claims description 193
- 238000004140 cleaning Methods 0.000 claims description 179
- 238000005406 washing Methods 0.000 claims description 147
- 238000002156 mixing Methods 0.000 claims description 113
- 230000005540 biological transmission Effects 0.000 claims description 78
- 238000003860 storage Methods 0.000 claims description 78
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- 239000000872 buffer Substances 0.000 claims description 51
- 238000011084 recovery Methods 0.000 claims description 47
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- 229910021641 deionized water Inorganic materials 0.000 claims description 29
- 238000002360 preparation method Methods 0.000 claims description 25
- 239000012459 cleaning agent Substances 0.000 claims description 21
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00207—Handling bulk quantities of analyte
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0437—Cleaning cuvettes or reaction vessels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- Health & Medical Sciences (AREA)
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- Immunology (AREA)
- Chemical & Material Sciences (AREA)
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Abstract
The invention discloses a full-automatic chemiluminescence immunoassay analyzer, which comprises a sample injection unit, a sample conveying unit and a detection unit; the sample conveying unit is matched with the sample feeding unit and used for conveying and transferring samples; the detection unit comprises a primary reaction module, a secondary reaction module, a detection module, a first incubation module, a second incubation module, a reaction cup automatic loading module and a reaction cup transferring module. The full-automatic chemical immunoassay analyzer has the advantages of small volume and high detection effect.
Description
Technical Field
The invention relates to the field of immunity analyzers, in particular to a full-automatic chemiluminescence immunity analyzer.
Background
A chemiluminescent immunoassay analyzer is a device for qualitatively or quantitatively detecting analytes in human serum, plasma or other body fluid samples by using chemiluminescent immunoassay technology.
The existing chemical immunoassay analyzer has the following problems:
1. The components of the existing chemical immunoassay analyzer are unreasonable in composition and arrangement, so that the existing chemical immunoassay analyzer is large in size and low in detection efficiency;
2. The existing chemical immunoassay analyzer has low automation degree, and the reaction cups need to be arranged in a directional way manually and placed into the chemical immunoassay analyzer;
3. the existing chemical immunity analyzer needs to manually prepare cleaning liquid, and has low preparation efficiency and easy manual error;
4. Most of the existing chemiluminescence immunoassay cannot realize emergency detection function and cannot meet the requirements of emergency detection.
In view of the above, it is necessary to develop a full-automatic chemiluminescence immunoassay analyzer to solve at least one of the above problems.
Disclosure of Invention
The invention aims to provide a full-automatic chemiluminescence immunoassay analyzer which aims at solving at least one technical problem in the prior art.
In order to achieve the above object, the solution of the present invention is:
A full-automatic chemiluminescence immunoassay analyzer comprises a sample injection unit, a sample conveying unit and a detection unit; the sample conveying unit is matched with the sample feeding unit and used for conveying and transferring samples; the detection unit comprises a primary reaction module, a secondary reaction module, a detection module, a first incubation module, a second incubation module, a reaction cup automatic loading module and a reaction cup transferring module; the first-stage reaction module comprises a reaction cup circulation device, a sample dispensing device, a first-stage reagent dispensing device, a second-stage reagent dispensing device and a first-stage mixing device, wherein the reaction cup circulation device is used for controlling the reaction cup to circulate at a reaction cup inlet and outlet station, a sample dispensing station, a first reagent dispensing station, a second reagent dispensing station and a first-stage mixing station, and the sample dispensing device, the first-stage reagent dispensing device, the second-stage reagent dispensing device and the first-stage mixing device are respectively corresponding to the sample dispensing station, the first reagent dispensing station, the second reagent dispensing station and the first-stage mixing station; the secondary reaction and detection module comprises a washing testing disc, a cleaning device, an excitation device, a photometry device, a secondary reagent dispensing device and a plurality of secondary mixing devices, wherein the cleaning device, the excitation device, the photometry device, the secondary reagent dispensing device and the secondary mixing devices are arranged around the washing testing disc; the washing and measuring optical disk is provided with a washing inner ring and a measuring outer ring which are mutually sleeved and can rotate; the reaction cup transfer module comprises a first reaction cup transfer device, a second reaction cup transfer device and a third reaction cup transfer device, wherein the first reaction cup transfer device is used for transferring reaction cups at the reaction cup automatic loading module, the reaction cup inlet and outlet station, the first incubation module and the washing inner ring, the second reaction cup transfer device is used for transferring reaction cups at the washing inner ring, the second incubation module and the photometry outer ring, and the third reaction cup transfer device is used for transferring reaction cups at the photometry outer ring and the discarding station.
The reaction cup circulation device comprises a circulation base, a runway track, a circulation mounting jig, a flexible transmission device and a circulation positioning mechanism; the runway-type track is arranged on the circulation base, and is provided with two opposite straight-line sections and two opposite arc sections, and two ends of the two arc sections are respectively connected through the two straight-line sections; the number of the circulation installation jigs is at least four, and each circulation installation jig is in sliding connection with the runway type track; the flexible transmission device is connected with each circulation installation jig and drives the circulation installation jigs to move along the runway track; the circulation positioning mechanism is movably positioned and matched with each circulation installation jig.
The circulation installation jig is provided with a jig positioning part, and the jig positioning part is provided with a positioning clamping groove; the circulation positioning mechanism comprises at least two circulation positioning devices, each circulation positioning device comprises a positioning shaft, a positioning driving motor for driving the positioning shaft to rotate and at least one positioning rod which is arranged on the positioning shaft and is intersected with the positioning shaft, and the positioning rods are movably clamped into positioning clamping grooves of the jig positioning parts of the circulation installation jig.
The positioning clamping groove of the jig positioning part of the circulation installation jig is perpendicular to the runway type track, the jig positioning part is further provided with two inclined guide surfaces respectively connected with two sides of the positioning clamping groove, and the positioning shaft and the positioning rod of the circulation positioning device are perpendicular to each other.
The automatic reaction cup loading module comprises a reaction cup hopper, a guide channel, a reaction cup pulling device, a guide channel and a reaction cup caching device; the reaction cup pulling device comprises a pulling disc rotatably arranged in a reaction cup hopper and a pulling rotation driving device for driving the pulling disc to rotate, at least one pulling claw is arranged on the periphery of the pulling disc, and a laterally convex grabbing hook is arranged at the end part of the pulling claw; the guide channel is arranged in the reaction cup hopper, the guide channel is provided with a feeding section and a discharging section which are communicated, the feeding section of the guide channel stretches into the reaction cup hopper, the feeding section of the guide channel is higher than the discharging section and the pulling disc, the feeding section is in an arc structure and is positioned on the rotating track of the grabbing hook, the lower side of the feeding section is provided with a feeding notch for the pulling claw and the grabbing hook of the pulling claw to enter and exit, and one side of the feeding notch penetrates through the inlet end of the feeding section; the reaction cup buffer device is connected with the outlet end of the discharging section of the guide channel.
The reaction cup caching device comprises a reaction cup caching base, a reaction cup caching rotary table in rotary fit with the reaction cup caching base, and a caching rotary driving device for driving the caching rotary table to rotate; the reaction cup buffer turntable is provided with a plurality of reaction cup buffer parts at the outlet end of the discharging section of the movable butt joint guide channel.
Each reaction cup buffer part of the reaction cup buffer turntable is arranged at the periphery of the reaction cup buffer turntable, and the upper side and the outer side of the reaction cup buffer part are both provided with openings; the reaction cup buffering base is provided with an annular retaining wall surrounding the reaction cup buffering turntable, the annular retaining wall is provided with a connection notch for abutting against the outlet end of the discharging section of the guide channel, and the connection notch is movably abutted against the outer side opening of each reaction cup buffering part.
The reaction cup hopper is provided with at least one elastic poking plate which is higher than the rotation center of the poking plate, and the elastic poking plate is positioned on the rotation track of the grabbing hook and opposite to the feeding section of the guide channel.
The automatic reaction cup loading module further comprises a reaction cup storage device matched with the reaction cup hopper; the reaction cup storage device comprises a reaction cup storage bin and a feed supplementing conveyor belt; the reaction cup bin is matched with the upper part of the reaction cup hopper, one side of the reaction cup bin is provided with a feeding hole communicated with the inner cavity of the reaction cup hopper, the feeding hole is matched with an elastic baffle plate, the feeding conveyer belt is matched with the reaction cup bin and the reaction cup hopper, and the upper side of a belt of the feeding conveyer belt is connected with the elastic baffle plate.
The sample conveying unit comprises a sample conveying device, a recovery conveying device, an emergency conveying device and a conveying switching device for conveying samples between the sample conveying device and the recovery conveying device; the sample injection unit comprises a common sample area, a recovery sample area, an emergency sample area, a sample buffer area and a sample transfer device; the sample transfer device is movably matched with the common sample area, the recovery sample area, the emergency sample area, the sample buffer area, the sample feeding and conveying device, the recovery and conveying device and the emergency conveying device and is used for transferring samples.
The sample transfer device comprises a sample taking and placing device and a transfer translation driving device for driving the sample taking and placing device to translate; the sample taking and placing device comprises a taking and placing track, a hooking device capable of translating along the taking and placing track, and a hooking translation driving device for driving the hooking device to translate along the taking and placing track; the picking and placing track and the hooking translation driving device are arranged on the transferring translation driving device; the common sample area is provided with a common placing rail for being in butt joint with the taking and placing rail; the recovery sample area is provided with a common recovery track for being in butt joint with the picking and placing track, and the emergency sample area is provided with an emergency track for being in butt joint with the picking and placing track; the sample buffer has a buffer track for interfacing with a pick-and-place track.
The hooking device comprises a hooking plate and a hooking plate motor for driving the hooking plate to rotate; the bottom side of the picking and placing track is provided with a movable opening for the hook plate to move; the bottoms of the common placing rail, the common recycling rail, the emergency rail and the cache rail are respectively provided with a movable opening for the hook plate to move.
The sample feeding unit further comprises three connecting conveying devices which are respectively connected with the sample feeding conveying device, the recovery conveying device and the emergency conveying device, wherein the connecting conveying devices comprise connecting conveying rails which are used for being in butt joint with the picking and placing rails and connecting belt conveying devices which are arranged in the connecting conveying rails.
The sample feeding conveying device comprises a sample feeding conveying rail and a sample feeding belt conveying device arranged in the sample feeding conveying rail; the recovery conveying device comprises a recovery conveying rail and a recovery belt conveying device arranged in the recovery conveying rail; the emergency conveying device comprises an emergency conveying track and an emergency belt conveying device arranged in the emergency conveying track; the conveying switching device comprises a switching frame and a switching translation driving device, wherein the switching frame is used for moving back and forth at the end parts of the sample feeding belt conveying device and the recycling belt conveying device, and the switching translation driving device is used for driving the switching frame to translate, and the switching frame is provided with a switching guide groove which is movably butted with the sample feeding conveying track and the recycling conveying track.
The primary mixing device and the secondary mixing device have the same structure; the primary mixing device comprises a mixing bracket, a mixing motor, a transmission assembly, a rotating shaft and a mixing seat; the mixing bracket is provided with a limiting seat, the limiting seat is provided with a limiting hole penetrating up and down, and a limiting bearing is matched in the limiting hole; the mixing motor is arranged on the mixing bracket and positioned below the limiting seat, the mixing motor is in transmission connection with the rotating shaft through the transmission assembly, and the rotating shaft penetrates through the limiting bearing and is matched with the inner ring of the limiting bearing; the mixing seat is connected with the upper end of the rotating shaft, is eccentrically arranged with the rotating shaft and is positioned above the limiting seat.
The transmission assembly comprises a transmission screw rod and a transmission nut; the transmission screw rod is connected with the mixing motor, the top of the transmission screw rod is matched with a limiting block, the transmission nut is in threaded connection with the transmission screw rod, the transmission nut can slide off freely on the transmission screw rod, the transmission nut is movably propped against the lower side of the limiting block and is coaxially connected with the rotating shaft, and the transmission screw rod is sleeved in the rotating shaft.
The mixing seat is detachably connected with the upper end of the rotating shaft through a universal seat, the universal seat is rotatably connected with the mixing seat, and the universal seat is detachably connected with the upper end of the rotating shaft.
The detection unit further comprises a reagent placement device; the first primary reagent dispensing device, the second primary reagent dispensing device and the secondary reagent dispensing device are arranged around the reagent placing device, and the reagent placing device is provided with at least two reagent placing rings which are mutually sleeved and can rotate.
The first primary reagent dispensing device, the second primary reagent dispensing device and the second secondary reagent dispensing device have the same structure; the first primary reagent dispensing device comprises a reagent dispensing head, a reagent dispensing needle arranged on the reagent dispensing head, a reagent dispensing rotary driving device for driving the reagent dispensing head to rotate, and a reagent dispensing lifting driving device for driving the reagent dispensing rotary driving device to lift; the reagent dispensing needle can be arranged on the reagent dispensing head in a vertically movable mode, a reset spring is arranged between the reagent dispensing needle and the reagent dispensing head, and a reagent dispensing needle proximity switch for detecting whether the reagent dispensing needle is shifted is arranged on the reagent dispensing head.
The detection unit further comprises three needle washing devices which are respectively matched with the first primary reagent dispensing device, the second primary reagent dispensing device and the second secondary reagent dispensing device in a corresponding manner; the needle washing device is provided with a washing channel which is vertically communicated, the upper end of the washing channel is provided with a needle inlet hole, the lower end of the needle washing channel is provided with a waste liquid hole, the needle washing cylinder is also provided with at least one liquid inlet hole communicated with the needle washing channel, and the liquid inlet hole is used for inputting washing liquid.
The sample dispensing device comprises a sample dispensing head, a sample dispensing needle arranged on the sample dispensing head, a sample dispensing rotary driving device for driving the sample dispensing head to rotate, and a sample dispensing lifting driving device for driving the sample dispensing rotary driving device to lift; the sample dispensing needle can be arranged on the sample dispensing head in a vertically movable mode, a reset spring is arranged between the sample dispensing needle and the sample dispensing head, and a sample dispensing needle proximity switch for detecting whether the sample dispensing needle is shifted is arranged on the sample dispensing head.
The detection unit further comprises a needle washing assembly correspondingly matched with the sample dispensing device; the needle washing assembly comprises a washing frame, a washing needle cylinder matched with the washing frame and a cleaning agent container for containing cleaning agent; the needle washing cylinder is provided with a needle washing channel which is vertically communicated, the upper end of the needle washing channel is provided with a needle inlet, the lower end of the needle washing channel is provided with a waste liquid outlet, and the needle washing cylinder is also provided with at least one liquid inlet communicated with the needle washing channel, and the liquid inlet is used for inputting cleaning liquid.
The full-automatic chemiluminescence immunoassay analyzer further comprises a cleaning liquid preparation device and a waste liquid collection device, wherein the cleaning liquid preparation device is matched with the detection unit, the cleaning liquid preparation device is used for providing cleaning liquid for the detection unit, and the waste liquid collection device is used for recycling waste liquid output by the detection unit; the cleaning liquid preparation device comprises a deionized water storage container, a concentrated liquid storage container, a cleaning liquid storage container, a first peristaltic pump, a second peristaltic pump, a conductivity tester and a liquid preparation controller; the liquid inlet end and the liquid outlet end of the first peristaltic pump are respectively connected with the deionized water storage container and the cleaning liquid storage container; the liquid inlet end and the liquid outlet end of the second peristaltic pump are respectively connected with the concentrated liquid storage container and the cleaning liquid storage container; the conductivity tester is matched with the cleaning liquid storage container and used for testing the conductivity of the cleaning liquid contained in the cleaning liquid storage container; the liquid distribution controller is electrically connected with the first peristaltic pump, the second peristaltic pump and the conductivity tester respectively; the waste liquid storage module comprises a waste liquid collection container and a multichannel peristaltic pump connected with the waste liquid collection container.
The cleaning liquid preparation device also comprises a circulating heating device matched with the cleaning liquid storage container, the circulating heating device is electrically connected with the liquid preparation controller, and the cleaning liquid storage container is matched with a temperature sensor electrically connected with the liquid preparation controller; the circulating heating device comprises a circulating heater and a circulating magnetic pump, wherein the liquid inlet end of the circulating magnetic pump is connected with the cleaning liquid storage container, the liquid inlet end of the circulating magnetic pump is connected with the liquid inlet end of the circulating heater, and the liquid outlet end of the circulating heater is connected with the cleaning liquid storage container; the circulating heater and the circulating magnetic pump are electrically connected with the liquid distribution controller.
The excitation device comprises an excitation head and an excitation lifting driving device for driving the excitation head to lift; the excitation head is provided with a pre-excitation liquid dispensing needle, an excitation liquid dispensing needle and a waste liquid sucking needle.
The cleaning device comprises a cleaning head and a cleaning lifting driving device for driving the cleaning head to lift; the cleaning head is provided with two cleaning units, and each cleaning unit is provided with at least one cleaning liquid dispensing needle and at least one waste liquid drawing needle.
The sample injection unit is arranged on the sample injection rack; the sample conveying unit and the detection unit are arranged on the detection rack; the sample feeding rack and the detection mechanism are close together.
After the scheme is adopted, the invention has the following characteristics:
1. The detection unit comprises a primary reaction module, a secondary reaction module, a detection module, a first incubation module, a second incubation module, an automatic reaction cup loading module and a reaction cup transferring module; the reaction cup circulation device is used for controlling the reaction cup to circulate at a reaction cup inlet and outlet station, a sample distribution station, a first reagent distribution station, a second reagent distribution station and a first-level mixing station, and the sample distribution device, the first-level reagent distribution device, the second first-level reagent distribution device and the first-level mixing device correspond to the sample distribution station, the first reagent distribution station, the second reagent distribution station and the first-level mixing station respectively; by the arrangement, the sample dispensing device, the first primary reagent dispensing device, the second primary reagent dispensing device and the primary mixing device are arranged around the reaction cup circulation device, so that the primary reaction module is compact in structure, and the chemical immunity analyzer is beneficial to reducing the volume; similarly, the secondary reaction and detection module comprises a washing optical measuring disc, a cleaning device, an excitation device, a photometry device, a secondary reagent dispensing device and a plurality of secondary mixing devices, wherein the cleaning device, the excitation device, the photometry device, the secondary reagent dispensing device and the secondary mixing devices are arranged around the washing optical measuring disc, so that the secondary reaction module is compact in structure due to the arrangement, and the chemical immunity analyzer is beneficial to reducing the volume. In addition, the primary reaction module and the secondary reaction and detection module can be independently operated, so that the detection efficiency is improved;
2. the automatic loading device for the reaction cup can realize the automatic directional loading of the reaction cup to the reaction cup buffer device, and is beneficial to improving the detection efficiency and the automation degree of the automatic loading device for the reaction cup;
3. The invention can form an urgent sample inlet and outlet sample channel through the urgent sample area, the sample transfer device and the urgent conveying device, thereby the full-automatic chemiluminescence immunoassay analyzer can realize urgent priority detection function;
4. According to the invention, the cleaning liquid can be automatically configured through the cleaning liquid preparation device, so that the detection efficiency of the invention is improved, and the manual error is reduced.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic structural diagram of the second embodiment of the present invention.
Fig. 3 is a schematic diagram of a partial structure of the present invention.
Fig. 4 is a schematic diagram of a partial structure of the present invention.
Fig. 5 is a schematic diagram of a partial structure of the present invention.
Fig. 6 is a schematic structural view of a sample transfer apparatus according to the present invention.
Fig. 7 is a schematic structural view of a sample transfer unit of the present invention.
Fig. 8 is a schematic structural diagram of a reaction cup circulation device according to the present invention.
Fig. 9 is a schematic structural diagram of a reaction cup circulation device according to the present invention.
Fig. 10 is a schematic view showing a partial structure of a sample dispensing device according to the present invention.
FIG. 11 is a schematic view showing the cooperation of the sample dispensing device and the needle washing assembly according to the present invention.
Fig. 12 is a schematic view of the structure of the needle washing assembly of the present invention.
Fig. 13 is a cross-sectional view of a needle wash assembly of the present invention.
FIG. 14 is a schematic partial structure of the first primary reagent dispensing device of the present invention.
FIG. 15 is a schematic diagram showing the cooperation of the first primary reagent dispensing device and the needle washing device according to the present invention.
Fig. 16 is a schematic structural view of the needle washing device of the present invention.
Fig. 17 is a cross-sectional view of the needle washing device of the present invention.
Fig. 18 is a schematic structural diagram of a primary mixing device according to the present invention.
Fig. 19 is a schematic structural diagram of a primary mixing device according to the present invention.
Fig. 20 is a cross-sectional view of a primary mixing device of the present invention.
Fig. 21 is a second cross-sectional view of the primary mixing device of the present invention.
FIG. 22 is a schematic diagram showing a partial structure of a secondary reaction and detection module according to the present invention.
FIG. 23 is a schematic diagram showing a partial structure of a second-stage reaction and detection module according to the present invention.
Fig. 24 is a schematic structural diagram of a washing optical disc according to the present invention.
Fig. 25 is a schematic structural view of the cleaning device of the present invention.
Fig. 26 is a schematic structural view of an excitation device according to the present invention.
Fig. 27 is a schematic structural view of a photometry device according to the present invention.
Fig. 28 is a schematic structural view of a first incubation module according to the invention.
Fig. 29 is a schematic structural view of a second incubation module according to the invention.
FIG. 30 is a schematic view showing the structure of the automatic loading module for the reaction cup according to the present invention.
FIG. 31 is a cross-sectional view of the automatic cuvette loading module according to the present invention.
FIG. 32 is a second cross-sectional view of the automatic cuvette loading module according to the present invention.
FIG. 33 is a third cross-sectional view of the automatic cuvette loading module according to the present invention.
FIG. 34 is a cross-sectional view of a cuvette auto-load module according to the present invention.
FIG. 35 is a schematic view showing the structure of a first cuvette transfer apparatus according to the present invention.
FIG. 36 is a schematic view showing the structure of a second cuvette transfer apparatus according to the present invention.
FIG. 37 is a schematic structural view of a third reaction cup transfer device of the present invention.
FIG. 38 is a schematic view showing the structure of the reagent holding apparatus of the present invention.
FIG. 39 is a schematic view showing a partial structure of the reagent holding apparatus of the present invention.
Description of the reference numerals:
A sample introduction unit 1, a normal sample area 111, a normal placement rail 111, a recovered sample area 12, a normal recovery rail 121, an emergency sample area 13, an emergency rail 131, a sample buffer area 14, a buffer rail 141, a sample transfer device 15, a sample taking and placing device 151, a taking and placing rail 1511, a hooking device 1512, a hooking plate 15121, a hooking plate motor 15122, a hooking translation driving device 1513, a transfer translation driving device 152, an engagement conveying device 16, an engagement conveying rail 161, an engagement belt conveying device 162,
The sample delivery unit 2,
The sample feeding and conveying device 21, the sample feeding and conveying rail 211, the sample feeding and conveying belt device 212,
A recovery conveyor 22, a recovery conveyor rail 221, a recovery belt conveyor 222,
An emergency conveying device 23, an emergency conveying rail 231, an emergency belt conveying device 232,
The conveying switching device 24, the switching frame 241, the switching guide groove 2411, the switching translation driving device 242,
The detection unit 3 is configured to detect,
The primary reaction module 31,
The reaction cup circulation device A is used for circulating the reaction cup,
The circulation base A1 is provided with a circulation device,
Runway type track A2, straight line section a21, arc section a22,
A circulation installation jig A3, a guide wheel A31, an annular guide groove A311, a reaction cup installation hole A32, a jig positioning part A33, a positioning clamping groove A331, an inclined guide surface A332,
The flexible transmission means A4 is arranged in the housing,
A circulation positioning device A5, a positioning shaft A51, a positioning driving motor A52, a positioning rod A53 and a bearing seat A54,
A sample dispensing device B, a sample dispensing head B1, a sample dispensing needle B2, a sample dispensing rotary driving device B3, a sample dispensing lifting driving device B4, a sample dispensing needle proximity switch B5,
A first primary reagent dispensing device C, a reagent dispensing head C1, a reagent dispensing needle C2, a reagent dispensing rotary driving device C3, a reagent dispensing lifting driving device C4, a reagent dispensing needle proximity switch C5,
A second-stage reagent dispensing device D,
A primary mixing device E, a mixing bracket E1, a limiting seat E11, a limiting hole E111, a supporting seat E12 and a supporting rod E13,
The motor E2 is evenly mixed and then is arranged,
A transmission component E3, a transmission screw rod E31, a transmission nut E32, a limiting block E33, an elastic washer E34,
A rotation shaft E4,
The mixing seat E5, the groove E51,
A limit bearing E6, which is provided with a limit bearing,
The coupling E7, the elastic pad E71,
The general purpose seat E8 is provided with a seat,
The position sensor E9 is provided with a position sensor,
A secondary reaction and detection module 32,
Washing the optical measuring disk a, washing the inner ring a1, measuring the outer ring a2,
A cleaning device b, a cleaning head b1, a cleaning unit b11, a cleaning liquid dispensing needle b111, a waste liquid drawing needle b112, a cleaning lifting driving device b2,
An excitation device c, an excitation head c1, a pre-excitation liquid dispensing needle c11, an excitation liquid dispensing needle c12, a waste liquid sucking needle c13, an excitation lifting driving device c2,
The light measuring device d is provided with a light measuring device,
A secondary reagent dispensing device e,
A secondary mixing device f for mixing the materials,
The first incubation module 33, the first incubation tray 331, the first incubation tray translation drive 332,
A second incubation module 34, a second incubation plate 341, a second incubation plate translation drive 342,
The cuvette is automatically loaded with a module 35,
The reaction cup hopper 351, the hopper feed switch 3511,
A reaction cup pulling device 352, a pulling disc 3521, a pulling claw 35211, a gripping hook 35212, a pulling rotation driving device 3522,
Guide channel 353, feed section 3531, feed gap 35311, inlet end 35312, discharge section 3532, outlet end 35321,
The reaction cup buffer device 354, the reaction cup buffer base 3541, the annular retaining wall 35411, the connection notch 35412, the reaction cup buffer rotary table 3542, the reaction cup buffer part 35421, the buffer rotary driving device 3543, the rotary encoder 3544,
The elastic pulling plate 355 is provided with a pair of elastic pulling plates,
Reaction cup stock device 356, reaction cup stock bin 3561, feed supplement port 35611, stock bin alarm switch 35612, feed supplement conveyor 3562, elastic baffle 3563,
The cuvette transfer module 36,
First cuvette transfer means 361, first motorized clasps 3611, first cuvette lift drive means 3612, first cuvette translation drive means 3613,
Second cuvette transfer means 362, second motorized clasps 3621, second cuvette lift drive means 3622, second cuvette translation drive means 3623,
Third cuvette transfer means 363, third motorized gripper 3631, third cuvette lift drive means 3632, third cuvette translational drive means 3633, fourth cuvette translational drive means 3634,
A needle washing assembly 37, a cleaning frame 371, a placing cylinder 3711, a needle washing cylinder 372, a needle washing channel 3720, a needle inlet 3721, a stopping edge 3725, a waste liquid port 3722, an upper liquid inlet 3723, a lower liquid inlet 3724, a cleaning agent container 373,
Needle washing device 38, washing channel 380, needle inlet hole 381, waste liquid hole 382, upper liquid inlet hole 383, and lower liquid inlet hole 384.
The reagent placement device 39,
A sample feeding rack 4,
The detection frame 5 is provided with a plurality of detection units,
A cleaning liquid preparation device 6, a deionized water storage container 61, a concentrated liquid storage container 62, a cleaning liquid storage container 63, a first peristaltic pump 64, a second peristaltic pump 65, a conductivity tester 66, a circulating heating device 67, a circulating heater 671, a circulating magnetic pump 672, a liquid adding device 68, a deionized water external joint 681, a liquid adding peristaltic pump 682, a first electromagnetic valve 683, a second electromagnetic valve 684,
Waste liquid collecting device 7, waste liquid collecting container 71, multichannel peristaltic pump 72.
Detailed Description
In order to further explain the technical scheme of the invention, the invention is explained in detail by specific examples.
As shown in fig. 1 to 39, the present invention discloses a full-automatic chemiluminescence immunoassay analyzer, which comprises a sample introduction unit 1, a sample conveying unit 2 and a detection unit 3; the sample conveying unit 2 is matched with the sample feeding unit 1 and is used for conveying and transferring samples; the detection unit 3 comprises a primary reaction module 31, a secondary reaction module 32, a first incubation module 33, a second incubation module 34, a reaction cup automatic loading module 35 and a reaction cup transferring module 36; the first-stage reaction module 31 comprises a reaction cup circulation device a, a sample dispensing device B, a first-stage reagent dispensing device C, a second-stage reagent dispensing device D and a first-stage mixing device E, wherein the reaction cup circulation device a is used for controlling a reaction cup to circulate at a reaction cup inlet and outlet station, a sample dispensing station, a first reagent dispensing station, a second reagent dispensing station and a first-stage mixing station, and the sample dispensing device B, the first-stage reagent dispensing device C, the second-stage reagent dispensing device D and the first-stage mixing device E correspond to the sample dispensing station, the first reagent dispensing station, the second reagent dispensing station and the first-stage mixing station respectively; the secondary reaction and detection module 32 comprises a washing optical measuring disc a, a cleaning device b, an excitation device c, a photometry device d, a secondary reagent dispensing device e and a plurality of secondary mixing devices f, wherein the cleaning device b, the excitation device c, the photometry device d, the secondary reagent dispensing device e and the plurality of secondary mixing devices f are arranged around the washing optical measuring disc a; the washing and measuring optical disk a is provided with a washing inner ring a1 and a measuring outer ring a2 which are mutually sleeved and can rotate; the reaction cup transferring module 36 includes a first reaction cup transferring device 361, a second reaction cup transferring device 362 and a third reaction cup transferring device 363, where the first reaction cup transferring device 361 is used for transferring reaction cups between the reaction cup automatic loading module 35, the reaction cup in-out station, the first incubation module 33 and the washing inner ring a1, the second reaction cup transferring device 362 is used for transferring reaction cups between the washing inner ring a1, the second incubation module 34 and the photometry outer ring a2, and the third reaction cup transferring device 363 is used for transferring reaction cups between the photometry outer ring a2 and the discarding station.
In the present invention, the detection unit 3 of the present invention includes a primary reaction module 31, a secondary reaction and detection module 32, a first incubation module 33, a second incubation module 34, a cuvette auto-loading module 35, and a cuvette transfer module 36; the first-stage reaction module 31 includes a reaction cup circulation device a, a sample dispensing device B, a first-stage reagent dispensing device C, a second first-stage reagent dispensing device D, and a first-stage mixing device E, where the reaction cup circulation device a is used to control circulation of a reaction cup at a reaction cup inlet and outlet station, a sample dispensing station, a first reagent dispensing station, a second reagent dispensing station, and a first-stage mixing station, and the sample dispensing device B, the first-stage reagent dispensing device C, the second first-stage reagent dispensing device D, and the first-stage mixing device E are respectively corresponding to the sample dispensing station, the first reagent dispensing station, the second reagent dispensing station, and the first-stage mixing station; by the arrangement, the sample dispensing device B, the first primary reagent dispensing device C, the second primary reagent dispensing device D and the primary mixing device E are arranged around the reaction cup circulation device A, so that the primary reaction module 31 is compact in structure, and the chemical immunity analyzer is beneficial to reducing the volume; similarly, the secondary reaction and detection module 32 includes a washing optical measuring disc a, a cleaning device b, an excitation device c, a light measuring device d, a secondary reagent dispensing device e and a plurality of secondary mixing devices f, which are arranged around the washing optical measuring disc a, so that the secondary reaction module is compact in structure and contributes to reducing the volume of the chemical immunoassay analyzer of the present invention. In addition, the primary reaction module 31 and the secondary reaction and detection module 32 of the present invention can be independently operated, which contributes to improvement of detection efficiency.
To facilitate understanding of the present invention, the working procedure of the present invention is described as follows:
The sample injection unit 1 firstly conveys a sample to the sample conveying unit 2, the first reaction cup transferring device 361 conveys the reaction cup automatic loading module 35 to a reaction cup inlet and outlet station of the reaction cup circulation device A, the reaction cup circulation device A controls the reaction cup to sequentially flow through a sample dispensing station, a first reagent dispensing station, a second reagent dispensing station, a first-level mixing station and the reaction cup inlet and outlet station, and the sample dispensing device B, the first-level reagent dispensing device C, the second-level reagent dispensing device D and the first-level mixing device E sequentially perform sample dispensing, first reagent dispensing, second reagent dispensing and first-level mixing;
after the primary mixing is completed, the first reaction cup transferring device 361 conveys the reaction cup from the reaction cup inlet and outlet station to the first incubation module 33 for first incubation;
after the first incubation is completed, the first reaction cup transferring device 361 conveys the reaction cup to the washing inner ring a1 of the washing optical disk a, and the first washing and reagent dispensing are sequentially carried out by the washing device b and the secondary reagent dispensing device e;
after the first wash and reagent dispensing is completed, the second cuvette transfer unit 362 delivers the cuvette to the second incubation module 34 for a second incubation;
After the second incubation is completed, the second reaction cup transfer device 362 conveys the reaction cup to the photometry outer ring a2 of the washing photometry disc a, and the cleaning device b, the excitation device c and the photometry device d sequentially perform the second cleaning, excitation and photometry detection;
After the second cleaning, excitation and photometric detection is completed, the third cuvette transfer unit 363 delivers the cuvette to a discard station for discarding.
In the embodiment of the invention, the sample feeding unit 1 is arranged on a sample feeding rack 4; the sample conveying unit 2 and the detection unit 3 are arranged on the detection rack 5; the sample feeding rack 4 and the detection mechanism are close together; by the arrangement, different sampling units 1 can be selected according to requirements to adapt to the sample conveying unit 2 and the detection unit 3, so that the flexibility of the whole product is improved.
In an embodiment of the present invention, the sample transporting unit 2 includes a sample transporting device 21, a recovery transporting device 22, an emergency transporting device 23, and a transporting switching device 24 for transporting a sample between the sample transporting device 21 and the recovery transporting device 22; the sample injection unit 1 comprises a common sample area 11, a recovered sample area 12, an emergency sample area 13, a sample buffer area 14 and a sample transfer device 15; the sample transfer device 15 is movably matched with the common sample area 11, the recovered sample area 12, the urgent sample area 13, the sample buffer area 14, the sample feeding and conveying device 21, the recovered conveying device 22 and the urgent conveying device 23 and is used for transferring samples; the rapid sample inlet and outlet channel can be formed by the rapid sample area 13, the sample transfer device 15 and the rapid conveying device 23, so that the full-automatic chemiluminescence immunoassay analyzer can realize the rapid priority detection function. In the invention, in a normal state, the normal sample is firstly put into the normal sample area 11, and then the normal sample in the normal sample area 11 is transferred to the sample buffer area 14 by the sample transfer device 15. When the normal detection is to be performed, the sample transfer device 15 transfers the normal sample in the sample buffer 14 to the sample feeding and conveying device 21, then the detection unit 3 samples and detects the normal sample, then the conveying and switching device 24 transfers the normal sample on the sample feeding and conveying device 21 to the recovery and conveying device 22, the recovery and conveying device 22 conveys the normal sample back to the sample transfer device 15, then the sample transfer device 15 transfers the normal sample back to the sample buffer 14 for temporary placement, after the detection result is out, if the detection result is normal, the sample transfer device 15 transfers the normal sample temporarily placed in the normal sample buffer 14 back to the normal sample region 11 for placement, and if the detection result is abnormal, the sample transfer device 15 transfers the normal sample temporarily placed in the normal sample buffer 14 back to the sample feeding and conveying device 21 and re-samples and detects by the detection unit 3, so that the automatic re-detection is realized. When the emergency priority detection is to be performed, an emergency sample is placed in the emergency sample area 13, the sample transfer device 15 transfers the emergency sample in the emergency sample area 13 to the emergency conveying device 23, then the emergency sample is sampled and detected by the detection unit 3, then the emergency sample is conveyed to the sample transfer device 15 by the emergency conveying device 23, and then the emergency sample is transferred to the emergency sample area 13 by the sample transfer device 15 for placement.
In an embodiment of the present invention, the sample transferring device 15 may include a sample taking and placing device 151, and a transferring and translating driving device 152 for driving the sample taking and placing device 151 to translate; the sample picking and placing device 151 includes a picking and placing track 1511, a picking device 1512 capable of translating along the picking and placing track 1511, and a picking and translating driving device 1513 for driving the picking device 1512 to translate along the picking and placing track 1511; the pick-and-place rail 1511 and the hooking translation driving device 1513 are mounted on the transfer translation driving device 152; the normal sample area 11 has a normal placement rail 111 for interfacing with a pick-and-place rail 1511; the recovery sample section 12 has a normal recovery track 121 for interfacing with a pick-and-place track 1511, and the emergency sample section 13 has an emergency track 131 for interfacing with a pick-and-place track 1511; the sample buffer 14 has a buffer track 15 for interfacing with a pick-and-place track 1511. In the invention, the urgent sample and the normal sample are placed on the sample rack, the normal placing rail 111, the normal recycling rail 121, the urgent rail 131 and the buffer rail 15 can be used for placing the sample rack, the hooking device 1512 is used for hooking the sample rack, and then the sample rack is driven by the hooking translation driving device 152, so that the movement of the sample rack between the normal placing rail 111 and the picking and placing rail 1511, between the normal recycling rail 121 and the picking and placing rail 1511, between the urgent rail 131 and the picking and placing rail 1511 and between the buffer rail 15 and the picking and placing rail 1511 is realized. The hooking device 1512 may include a hooking plate 15121 and a hooking plate click 1512213122 for driving the hooking plate 15121 to rotate, wherein the hooking plate 15121 is used for hooking the bottom of the sample rack; a movable opening for the hook plate 15121 to move is formed at the bottom side of the pick-and-place rail 1511 to ensure the movement of the hook plate 15121; the bottoms of the normal placing rail 111, the normal recycling rail 121, the emergency rail 131 and the buffer rail 15 are respectively provided with a movable opening for the hook plate 15121 to move so as to ensure the movement of the hook plate 15121.
In the embodiment of the present invention, the sample feeding unit 1 further includes three engagement conveying devices 16 engaged with the sample feeding conveying device 21, the recovery conveying device 22 and the emergency conveying device 23, respectively, and the engagement conveying devices 16 include an engagement conveying rail 161 for interfacing with the pick-and-place rail 1511, and an engagement belt conveying device 162 disposed in the engagement conveying rail 161; the invention realizes the transfer of the normal sample and the urgent sample between the sample transfer device 15 and the sample transfer unit 2 by three connection transfer devices 16; the three engagement conveyor 16 can facilitate the docking between the sample introduction rack 4 and the detection rack 5.
In the embodiment of the present invention, the sample conveying device 21 of the sample conveying unit 2 includes a sample conveying track 211 and a sample belt conveying device 212 disposed in the sample conveying track 211, where the sample belt conveying device 212 can drive the sample rack to move along the sample conveying track 211; the recovery conveying device 22 of the sample conveying unit 2 comprises a recovery conveying rail 221 and a recovery belt conveying device 222 arranged in the recovery conveying rail 221, wherein the recovery belt conveying device 222 can drive the sample rack to move along the recovery conveying rail 221; the emergency conveying device 23 of the sample conveying unit 2 comprises an emergency conveying rail 231 and an emergency belt conveying device 232 arranged in the emergency conveying rail 231, wherein the emergency belt conveying device 232 can drive the sample rack to move along the emergency conveying rail 231; the conveying switching device 24 of the sample conveying unit 2 comprises a switching frame 241 for moving back and forth at the ends of the sample conveying belt device 212 and the recovery belt conveying device 222, and a switching translation driving device 242 for driving the switching frame 241 to translate, wherein the switching frame 241 is provided with a switching guide groove 2411 movably butted with the sample conveying rail 211 and the recovery conveying rail 221; the transport switching device 24 operates in the following manner: the switching translation driving device 242 drives the switching frame 241 to translate to the switching guide groove 2411 to align with the sample feeding conveying track 211; then, the sample belt conveyor 212 drives the sample rack to move into the switching guide groove 2411; then, the switching translation driving device 242 drives the switching frame 241 to translate to the switching guide groove 2411 to align with the recovery conveying track 221, and the recovery belt conveying device 222 drives the sample frame to move from the switching guide groove 2411 into the recovery conveying track 221, so as to realize the switching of the sample frame from the sample feeding conveying device 21 to the recovery conveying device 22.
In the embodiment of the invention, the reaction cup circulation device A comprises a circulation base A1, a runway track A2, a circulation mounting jig A3, a flexible transmission device A4 and a circulation positioning mechanism; the runway-type track A2 is arranged on the circulation base A1, the runway-type track A2 is provided with two opposite straight line sections A21 and two opposite arc sections A22, and two ends of the two arc sections A22 are respectively connected through the two straight line sections A21; the number of the circulation installation jigs A3 is at least two, each circulation installation jig A3 is in sliding connection with the track type track A2, and the circulation installation jigs A3 are used for placing reaction cups; the flexible transmission device A4 is connected with each circulation installation jig A3 and drives the circulation installation jigA 3 to move along the runway track A2; the circulation positioning mechanism is movably positioned and matched with each circulation installation jig A3. According to the full-automatic chemiluminescence immunoassay analyzer, each circulation mounting jig A3 moves on the runway-type track A2, and the space occupation of the runway-type track A2 is smaller than that of the round turntable, so that the reaction cup circulation device A has the advantage of small occupied space, and the full-automatic chemiluminescence immunoassay analyzer is beneficial to reducing the volume of the full-automatic chemiluminescence immunoassay analyzer. In addition, the invention also has a circulation positioning mechanism which is movably matched with each circulation installation jig A3, so that the circulation installation jigA 3 can be positioned on a required station through the circulation positioning mechanism, and the problem that the circulation installation jigA 3 cannot accurately move on the required station due to the speed difference of the circulation installation jigA 3 on the straight line section A21 and the arc section A22 of the runway type track A2 is avoided.
In an embodiment of the present invention, the flexible transmission device A4 is a synchronous belt transmission device. It should be noted that, the flexible transmission device A4 may also be a chain transmission device, and both the chain transmission device and the synchronous belt transmission device may drive the circulation installation fixture A3 to move along the track type track A2.
In the embodiment of the invention, the circulation installation jig A3 is provided with a plurality of guide wheels a31 which are respectively in sliding contact with two sides of the runway type track A2, so that the circulation installation jig A3 moves more stably. The guide wheel A31 is provided with an annular guide groove A311 which is matched with the side wall of the runway type track A2, so that the guide wheel A31 is prevented from falling out of the runway type track A2, and the circulation installation jig A3 is more stably matched with the runway type track A2.
In the embodiment of the invention, the circulation installation jig A3 is provided with the reaction cup installation hole a32, the reaction cup installation hole a32 is used for inserting the reaction cup, and the reaction cup installation hole a32 is positioned at the outer side of the runway track A2, so that the interference between a device for operating the reaction cup and the runway track A2 can be avoided.
In the embodiment of the invention, the circulation installation jig A3 is provided with a jig positioning part a33, and the jig positioning part a33 is provided with a positioning clamping groove a331; the circulation positioning mechanism comprises at least two circulation positioning devices A5, wherein the circulation positioning devices A5 comprise a positioning shaft A51, a positioning driving motor A52 for driving the positioning shaft A51 to rotate and at least one positioning rod A53 which is arranged on the positioning shaft A51 and is intersected with the positioning shaft A51, and the positioning rod A53 is movably clamped into a positioning clamping groove A331 of a jig positioning part A33 of the circulation installation jig A3. The positioning rods A53 of the circulation positioning devices A5 are respectively arranged corresponding to the stations, and when the positioning rods A53 of the circulation positioning devices A5 circulate and install the positioning part A33 of the jig A3, the circulation and installation jig A3 is positioned to the corresponding station. The circulation positioning device A5 may have a plurality of positioning rods a53 so that one circulation positioning device A5 can simultaneously position a plurality of circulation installation jigs A3.
In the embodiment of the invention, the positioning clamping groove A331 of the jig positioning part A33 of the circulation installation jig A3 is perpendicular to the runway track A2, so that deflection of the circulation installation jig A3 can be reduced when the positioning rod A53 of the circulation positioning device A5 is clamped into the positioning clamping groove A331 of the circulation installation jig A3, and the cooperation stability of the circulation installation jig A3 and the runway track A2 is protected. Correspondingly, the positioning shaft a51 and the positioning rod a53 of the circulation positioning device A5 are perpendicular to each other, so that the rotation of the positioning shaft a51 can control the positioning rod a53 to enter and exit the positioning clamping groove a331. The jig positioning part A33 of the circulation installation jig A3 is further provided with two inclined guide surfaces A332 which are respectively connected with two sides of the positioning clamping groove A331, and the arrangement of the inclined guide surfaces A332 can play a role in avoiding and guiding the positioning rod A53, so that the positioning rod A53 can be accurately clamped into the positioning clamping groove A331.
In the embodiment of the invention, two ends of a positioning shaft A51 of the circulation positioning device A5 are respectively supported in a bearing seat A54, and the bearing seat A54 is fixedly arranged on a circulation base A1; by the arrangement, the positioning shaft A51 can be enabled to rotate more stably; the positioning driving motor A52 of the circulation positioning device A5 can be coaxially connected with the positioning shaft A51 through a coupler, and the positioning driving motor A52 is fixedly arranged on the circulation base A1.
In an embodiment of the present invention, the circulation positioning mechanism may include four circulation positioning devices A5, where the positioning axes a51 of two circulation positioning devices A5 are disposed parallel to the straight line segment a21 of the runway-type track A2, and the positioning axes a51 of the other two circulation positioning devices A5 are disposed perpendicular to the straight line segment a21 of the runway-type track A2, so that the circulation mounting fixture A3 may be positioned at least four places by the four circulation positioning devices A5 corresponding to the two straight line segments a21 and the two arc segments a22 of the runway-type track A2. The circulation positioning devices A5 of the circulation positioning mechanism may be disposed outside the runway-type track A2, and the flexible transmission device A4 may be disposed inside the runway-type track A2.
In an embodiment of the present invention, the sample dispensing device includes a sample dispensing head B1, a sample dispensing needle B2 mounted to the sample dispensing head B1, a sample dispensing rotation driving device B3 driving the sample dispensing head B1 to rotate, a sample dispensing lifting driving device B4 driving the sample dispensing rotation driving device B3 to lift, and a sample sucking and releasing device B2 sucking and releasing a sample by the sample dispensing rotation driving device B3, the sample dispensing device B being capable of dispensing the sample on the sample conveying unit 2 to a cuvette placed on a cuvette in-out station for sample dispensing. The sample dispensing needle B2 can be arranged on the sample dispensing head B1 in a vertically movable mode, a reset spring is arranged between the sample dispensing needle B2 and the sample dispensing head B1, and a sample dispensing needle proximity switch B5 for detecting whether the sample dispensing needle B2 is shifted is arranged on the sample dispensing head B1; thus, when the sample dispensing needle B2 is driven to descend by the sample dispensing lifting driving device B4, if the sample dispensing needle B2 collides, the sample dispensing needle B2 can move upwards relative to the sample dispensing head B1 to protect the sample dispensing needle B2, and meanwhile, the sample dispensing needle proximity switch B5 detects that the sample dispensing needle B2 is shifted to send a firing pin alarm signal to alarm. In addition, the detection unit 3 further comprises a needle washing assembly 37 correspondingly matched with the sample dispensing device B so as to wash the sample dispensing needle B2; the needle washing assembly 37 comprises a washing frame 371, a washing cylinder 372 matched with the washing frame 371, and a washing agent container 373 for containing washing agent; the needle washing cylinder 372 is provided with a needle washing channel 3720 which is vertically communicated, a needle inlet 3721 is formed at the upper end of the needle washing channel 3720, a waste liquid port 3722 is formed at the lower end of the needle washing channel 3720, and the needle washing cylinder 372 is also provided with at least one liquid inlet which is communicated with the needle washing channel 3720 and is used for inputting cleaning liquid. The needle washing assembly 37 is further provided with the cleaning agent container 373 for containing the cleaning agent on the basis of the needle washing cylinder 372, so that the sample dispensing needle B2 can absorb the cleaning agent in the cleaning agent container 373 to effectively clean the inner wall of the sample dispensing needle B2, and the sample dispensing needle B2 can be well cleaned. And the cleaning agent sucked by the sample dispensing needle B2 is discharged by the waste liquid port 3722 of the cleaning needle cylinder 372 after the inner wall of the sample dispensing needle B2 is cleaned.
The following describes a method of performing two washes of the sample dispensing needle B2 using the needle wash assembly 37 of the present invention. Cleaning for the first time: the sample dispensing needle B2 is firstly inserted into the needle washing channel 3720 of the needle washing cylinder 372 from the needle inlet 3721 of the needle washing cylinder 372; then, the cleaning liquid is input into the needle washing channel 3720 from the liquid inlet of the needle washing cylinder 372 to clean the needle washing cylinder 372; after the washing is completed, the waste liquid in the needle washing channel 3720 is discharged from the waste liquid port 3722, and the sample dispensing needle B2 exits the needle washing channel 3720. And (3) cleaning for the second time: the sample dispensing needle B2 firstly sucks the cleaning agent in the cleaning agent container 373; then the sample dispensing needle B2 is inserted into the needle washing channel 3720 of the needle washing cylinder 372 from the needle inlet 3721 of the needle washing cylinder 372; then, the cleaning liquid is fed into the needle cleaning channel 3720 from the liquid inlet of the needle cleaning cylinder 372 to clean the needle cleaning cylinder 372, and the cleaning liquid is discharged to the needle cleaning channel 3720 from the sample dispensing needle B2; after the washing is completed, the waste liquid in the needle washing channel 3720 is discharged from the waste liquid port 3722, and the sample dispensing needle B2 exits the needle washing channel 3720. In order to ensure better cleaning effect, the concentration of cleaning substances of the cleaning agent is larger than that of the cleaning agent, and the cleaning agent can be diluted by the cleaning agent and deionized water.
In the embodiment of the present invention, the cleaning agent container 373 is detachably coupled to the cleaning frame 371 so as to directly supplement the cleaning agent by directly replacing the cleaning agent container 373, thereby facilitating the use. Specifically, the cleaning rack 371 is provided with a placing cylinder 3711, and the cleaning agent container 373 is placed in the placing cylinder 3711, so that the cleaning agent container 373 is convenient to take and place. The washing cylinder 372 can be locked with the cleaning frame 371 through screws, so that the installation stability of the washing cylinder 372 is ensured. The upper edge of the needle inlet 3721 of the syringe 372 forms a convex stopping edge 3725, and the stopping edge 3725 is used for preventing the cleaning liquid from overflowing from the needle inlet 3721. The liquid inlet of the syringe 372 is divided into an upper liquid inlet 3723 and a lower liquid inlet 3724, the upper liquid inlet 3723 is arranged at the upper part of the side wall of the syringe 372, and the lower liquid inlet 3724 is arranged at the lower part of the side wall of the syringe 372; by the arrangement, the external cleaning liquid can enter the needle washing channel 3720 more quickly, and meanwhile, the input cleaning liquid can be enabled to impact the upper portion and the lower portion of the sample dispensing needle B2 forcefully, so that the cleaning effect is guaranteed. Further, the number of the upper liquid inlets 3723 is at least two, and each upper liquid inlet 3723 is arranged in a central symmetry manner with respect to the needle washing channel 3720, so that the cleaning liquid input from each upper liquid inlet 3723 can form more powerful impact on the upper part of the sample dispensing needle B2, and the cleaning effect is further ensured; similarly, the number of the lower liquid inlets 3724 is at least two, and each lower liquid inlet 3724 is arranged in a central symmetry manner with respect to the needle washing channel 3720, so that the cleaning liquid input from each lower liquid inlet 3724 can form more powerful impact on the lower part of the sample dispensing needle B2, and the cleaning effect is further ensured.
Further, the needle washing cylinder 372 may be further provided with an overflow channel (not shown), the inner end of the overflow channel is communicated with the upper part of the needle washing channel 3720, the communication position between the overflow channel and the needle washing channel 3720 is lower than the needle inlet 3721, and the outer end of the overflow channel forms an overflow port; the present invention can avoid the overflow of cleaning liquid from the needle inlet 3721 through the overflow channel. In addition, the communicating position of the overflow channel and the needle washing channel 3720 is higher than each liquid inlet, so that the waste of the cleaning liquid caused by the direct discharge of the cleaning liquid input from the liquid inlet from the overflow channel is avoided.
In the embodiment of the invention, the first primary reagent dispensing device C, the second primary reagent dispensing device D and the secondary reagent dispensing device e have the same structure; specifically, the first primary reagent dispensing device C includes a reagent dispensing head C1, a reagent dispensing needle C2 mounted on the reagent dispensing head C1, a reagent dispensing rotation driving device C3 for driving the reagent dispensing head C1 to rotate, and a reagent dispensing lifting driving device C4 for driving the reagent dispensing rotation driving device C3 to lift; the first primary reagent dispensing device C, the second primary reagent dispensing device D and the secondary reagent dispensing device e can dispense the reagent to the reaction cup for reagent dispensing by the rotary drive of the reagent dispensing rotary drive device C3, the lifting drive of the reagent dispensing lifting drive device C4 and the sucking and releasing of the reagent by the reagent dispensing needle C2. The reagent dispensing needle C2 can be arranged on the reagent dispensing head C1 in a vertically movable mode, a reset spring is arranged between the reagent dispensing needle C2 and the reagent dispensing head C1, and a reagent dispensing needle proximity switch C5 for detecting whether the reagent dispensing needle C2 is shifted is arranged on the reagent dispensing head C1; thus, when the reagent dispensing lifting driving device C4 drives the reagent dispensing needle C2 to descend, if the reagent dispensing needle C2 collides, the reagent dispensing needle C2 can move upwards relative to the reagent dispensing head C1 to protect the reagent dispensing needle C2, and meanwhile, the reagent dispensing needle proximity switch C5 detects that the reagent dispensing needle C2 shifts to send a firing pin warning signal to warn. In addition, the detecting unit 3 further includes three needle washing devices 38 correspondingly matched with the first primary reagent dispensing device C, the second primary reagent dispensing device D and the secondary reagent dispensing device e, respectively, so as to wash the reagent dispensing needle C2; the needle washing device 38 is provided with a washing channel 380 which is vertically communicated, a needle inlet hole 381 is formed at the upper end of the washing channel 380, a waste liquid hole 382 is formed at the lower end of the needle washing channel 3720 to discharge waste liquid, and the needle washing cylinder 372 is also provided with at least one liquid inlet hole which is communicated with the needle washing channel 3720 and is used for inputting washing liquid.
The following describes a method of cleaning the reagent dispensing needle C2 using the needle cleaning assembly 37 of the present invention: the reagent dispensing needle C2 is inserted into the cleaning channel 380 of the needle washing device 38 from the needle inlet hole 381 of the needle washing device 38; then, the cleaning liquid is input into the cleaning channel 380 from the liquid inlet of the needle cleaning device 38 to clean the needle cleaning device 38; after the washing is completed, the waste liquid in the washing channel 380 is discharged from the waste liquid hole 382, and the reagent dispensing needle C2 exits the washing channel 380.
In the embodiment of the present invention, the liquid inlet holes of the needle washing device 38 are divided into an upper liquid inlet hole 383 and a lower liquid inlet hole 384, the upper liquid inlet hole 383 is disposed at the upper portion of the sidewall of the needle washing device 38, and the lower liquid inlet hole 384 is disposed at the lower portion of the sidewall of the needle washing device 38; so set up for outside washing liquid can enter into the washing passageway 380 more fast, can let the washing liquid of input simultaneously to the formation powerful impact of reagent divides the upper portion and the lower part of annotating needle C2, guarantee clean effect. Further, the number of the upper liquid inlet holes 383 is at least two, and each upper liquid inlet hole 383 is arranged in a central symmetry manner with respect to the cleaning channel 380, so that the cleaning liquid input from each upper liquid inlet hole 383 can form more powerful impact on the upper part of the reagent dispensing needle C2, and the cleaning effect is further ensured; similarly, the number of the lower liquid inlet holes 384 is at least two, and each lower liquid inlet hole 384 is arranged in a central symmetry manner with respect to the cleaning channel 380, so that the cleaning liquid input from each lower liquid inlet hole 384 can form more powerful impact on the lower part of the reagent dispensing needle C2, and the cleaning effect is further ensured.
In the embodiment of the invention, the primary mixing device E and the secondary mixing device f have the same structure; specifically, the primary mixing device E comprises a mixing bracket E1, a mixing motor E2, a transmission component E3, a rotating shaft E4 and a mixing seat E5; the mixing bracket E1 is provided with a limiting seat E11, the limiting seat E11 is provided with a limiting hole E111 penetrating up and down, and a limiting bearing E6 is matched in the limiting hole E111; the mixing motor E2 is arranged on the mixing bracket E1 and is positioned below the limiting seat E11, the mixing motor E2 is in transmission connection with the rotating shaft E4 through the transmission component E3, the rotating shaft E4 passes through the limiting bearing E6 and is matched with the inner ring of the limiting bearing E6, and the limiting bearing E6 plays a limiting role on the rotating shaft E4 so that the rotating shaft E4 can not shake when rotating; the mixing seat E5 is connected with the upper end of the rotating shaft E4, the mixing seat E5 and the rotating shaft E4 are eccentrically arranged, and the mixing seat E5 is positioned above the limiting seat E11.
In the embodiment of the present invention, the mixing bracket E1 is further provided with a supporting seat E12 located below the limiting seat E11, the supporting seat E12 is connected to the limiting seat E11 through a supporting rod E13, the mixing motor E2 is installed on the supporting seat E12, and the mixing motor E2 and the supporting seat E12 can be locked by screws.
In an embodiment of the present invention, the transmission assembly E3 includes a transmission screw E31 and a transmission nut E32; the transmission screw rod E31 is connected with the mixing motor E2, a limiting block E33 is matched at the top of the transmission screw rod E31, the transmission nut E32 is in threaded connection with the transmission screw rod E31, the transmission nut E32 can freely slide on the transmission screw rod E31, the transmission nut E32 movably abuts against the lower side of the limiting block E33 and is coaxially connected with the rotating shaft E4, and the transmission screw rod E31 is sleeved on the rotating shaft E4. According to the invention, through the arrangement of the transmission assembly E3, the rotating shaft E4 can be driven to rotate, and the rotating shaft E4 can be lifted. The working principle of the invention is as follows: according to the invention, when the mixing motor E2 does not drive the transmission screw rod E31 to rotate, the transmission nut E32 and the rotating shaft E4 can drive the mixing seat E5 to slide down to the lowest position due to self weight; when the mixing motor E2 drives the transmission screw rod E31 to rotate at a high speed, the transmission nut E32 and the rotating shaft E4 firstly rotate relative to the transmission screw rod E31 due to static inertia, so that the transmission nut E32, the rotating shaft E4 and the mixing seat E5 can rise upwards along the transmission screw rod E31; when the transmission nut E32 is lifted to be limited by the limiting block E33, at this time, the transmission nut E32, the rotating shaft E4 and the mixing seat E5 are not lifted any more, and at this time, the transmission nut E32 and the rotating shaft E4 rotate together with the transmission screw rod E31, so that the mixing seat E5 performs eccentric circular motion.
In the embodiment of the present invention, the mixing bracket E1 may be provided with a position sensor E9 for monitoring whether the rotation shaft E4 is lifted, and the position sensor E9 may be an infrared proximity switch; when the mixing motor E2 drives the transmission screw rod E31 to rotate at a high speed, if the position sensor E9 does not monitor that the rotating shaft E4 rises to a set position, the first-stage mixing device E or the second-stage mixing device f of the invention has faults, and the position sensor E9 can alarm outwards.
In the embodiment of the present invention, the transmission screw rod E31 may be sleeved with an elastic washer E34, where the elastic washer E34 is located at the lower side of the stopper E33, and the elastic washer E34 may play a role in buffering the transmission nut E32 to prevent the transmission nut E32 from striking the stopper E33.
In the embodiment of the invention, the mixing motor E2 is connected with the transmission screw rod E31 through a coupler E7, an elastic gasket E71 is matched at the top of the coupler E7, and the elastic gasket E71 can also play a role in buffering the transmission nut E32 so as to prevent the transmission nut E32 from impacting the coupler E7.
In the embodiment of the invention, the mixing seat E5 is detachably connected with the upper end of the rotating shaft E4 through a universal seat E8, the universal seat E8 is connected with the mixing seat E5, and the universal seat E8 is detachably connected with the upper end of the rotating shaft E4; by the arrangement, the mixing seats E5 with different types can be mounted on the rotating shaft E4 through the universal seat E8, and the use flexibility of the primary mixing device E and the secondary mixing device f is improved. Specifically, the universal seat E8 is locked with the upper end of the rotating shaft E4 through a pin, so that the universal seat E8 and the rotating shaft E4 are convenient to assemble and disassemble; and mixing seat E5 and general seat E8 swivelling joint, mixing seat E5 can also rotate when carrying out eccentric circular motion like this, can effectively improve the mixing effect to the reactant in the reaction cup, and mixing seat E5's up end is equipped with at least one recess E51, and recess E51 is used for cooperating and makes the reaction cup bottom can follow mixing seat E5 and move with the reaction cup bottom.
In the embodiment of the invention, the cleaning device b comprises a cleaning head b1 and a cleaning lifting driving device b2 for driving the cleaning head b1 to lift; the cleaning head b1 is provided with two cleaning units b11, each cleaning unit b11 having at least one cleaning liquid dispensing needle b111 and at least one waste liquid drawing needle b112. Each cleaning unit b11 of the cleaning device b is matched with the secondary mixing device f to complete cleaning operation, and the cleaning operation is specifically as follows: the cleaning liquid dispensing needle b111 of the cleaning unit b11 firstly adds the cleaning liquid into the reaction cup, then the secondary mixing device f mixes the reaction cup uniformly, and then the waste liquid in the reaction cup is extracted by the waste liquid extracting needle b112 of the cleaning unit b 11. Each of the washing units b11 may have a plurality of washing liquid dispensing needles b111 and a plurality of waste liquid drawing needles b112, so that washing operations can be performed on a plurality of reaction cups at the same time.
In the embodiment of the invention, the excitation device c comprises an excitation head c1 and an excitation lifting driving device c2 for driving the excitation head c1 to lift; the excitation head c1 is provided with a pre-excitation liquid dispensing needle c11, an excitation liquid dispensing needle c12 and a waste liquid sucking needle c13. The excitation head c1 of the excitation device c is matched with the secondary mixing device f to complete excitation operation, and the excitation operation is specifically as follows: the pre-excitation liquid dispensing needle c11 of the excitation head c1 firstly adds pre-excitation liquid into the reaction cup, then the secondary mixing device f mixes the reaction cup uniformly, then the waste liquid sucking needle c13 of the excitation head c1 extracts waste liquid in the reaction cup, and finally the excitation liquid dispensing needle c12 of the excitation head c1 adds excitation liquid into the reaction cup.
In an embodiment of the present invention, the first incubation module 33 has a first incubation plate translation driving device 332 for placing the reaction cups, the first incubation plate translation driving device 332 has a heating function, and the first incubation plate translation driving device 332 can be driven to translate by the first incubation plate translation driving device 332 translation driving device. Likewise, the second incubation module 34 has a second incubation plate 341 for placing the reaction cups, the second incubation plate 341 having a heating function, the second incubation plate 341 being translatable by a second incubation plate translation drive 342.
In the embodiment of the present invention, the automatic cuvette loading module 35 includes a cuvette hopper 351, a guide channel 353, a cuvette extraction device 352, a guide channel 353, and a cuvette buffer device 354; the reaction cup pulling device 352 comprises a pulling disc 3521 rotatably arranged in the reaction cup hopper 351 and a pulling rotation driving device 3522 for driving the pulling disc 3521 to rotate, at least one pulling claw 35211 is arranged on the periphery of the pulling disc 3521, and a laterally protruding grabbing hook 35212 is arranged at the end part of the pulling claw 35211; the guide channel 353 is installed in the reaction cup hopper 351, the guide channel 353 has a feeding section 3531 and a discharging section 3532 which are communicated, the feeding section 3531 of the guide channel 353 extends into the reaction cup hopper 351, the feeding section 3531 of the guide channel 353 is higher than the discharging section 3532 and the pulling plate 3521, the feeding section 3531 is in a circular arc structure and is positioned on the rotation track of the grabbing hook 35212, the lower side of the feeding section 3531 is provided with a feeding gap 35311 for the feeding claw 35211 and the grabbing hook 35212 of the pulling claw 35211 to enter and exit, and one side of the feeding gap 35311 penetrates through the inlet end 35312 of the feeding section 3531; the cuvette buffer 354 is connected to the outlet end 35321 of the discharge section 3532 of the guide channel 353. The main working principle of the automatic loading module 35 of the reaction cup of the invention is as follows: the pulling rotation driving device 3522 drives the pulling plate 3521 to rotate, and in the process of rotating the pulling plate 3521, the grabbing hooks 35212 of the pulling claw 35211 of the pulling plate 3521 can hook the reaction cup in the reaction cup hopper 351; along with the rotation of the pulling disc 3521, the pulling claw 35211 and the gripping hook 35212 thereof enter the feeding section 3531 of the guide channel 353 and then exit the feeding section 3531 of the guide channel 353, in the process, the reaction cup hooked by the gripping hook 35212 is left in the feeding section 3531 of the guide channel 353 under the action of inertia, the reaction cup entering the feeding section 3531 of the guide channel 353 is output to the reaction cup buffer device 354 along the discharging section 3532 of the guide channel 353 under the action of gravity, so that the reaction cup is loaded to the reaction cup buffer device 354, and the first reaction cup transfer device 361 transfers the reaction cup on the reaction cup buffer device 354 to the reaction cup in-out station. The reaction cup is hooked by the grabbing hook 35212 of the rotating pulling plate 3521 and is sent into the feeding section 3531 of the guide channel 353, so that the reaction cup can enter the guide channel 353 in a directional manner, and the guide channel 353 guides the reaction cup to enable the reaction cup to be accurately output to the reaction cup caching device 354; from the foregoing, it can be seen that the present invention can realize automatic directional loading of the reaction cup into the reaction cup buffer device 354, which is helpful for improving the detection efficiency and automation degree of the present invention.
In the embodiment of the present invention, the reaction cup hopper 351 is provided with at least one elastic pulling plate 355 higher than the rotation center of the pulling plate 3521, and the elastic pulling plate 355 is located on the rotation track of the grasping hook 35212 and opposite to the feeding section 3531 of the guiding channel 353; after the grabbing hook 35212 of the grabbing plate 3521 grabs the reaction cup, the elastic poking plate 355 can poke the reaction cup hooked by the grabbing hook 35212 along with the rotation of the grabbing plate 3521, so that the reaction cup is driven to be stably and accurately inserted into the grabbing hook 35212, and the reaction cup hooked by the grabbing hook 35212 can be ensured to enter the guide channel 353 in a directional manner. The discharge section 3532 of the guide channel 353 is inclined, so that the cuvette entering the guide channel 353 can be rapidly discharged to the cuvette buffer 354 along the discharge section 3532 of the guide channel 353 under the action of gravity. The stirring rotation driving device 3522 of the reaction cup stirring device 352 is disposed at the outer side of the reaction cup hopper 351, so as to avoid that the stirring rotation driving device 3522 occupies the inner space of the reaction cup hopper 351. The pulling rotation driving device 3522 may adopt a stepping motor, so as to conveniently control the rotation speed of the pulling plate 3521, and the pulling plate 3521 may be provided with a plurality of pulling claws 35211, so as to conveniently and rapidly send the reaction cup into the guide channel 353, and improve the loading efficiency.
In the embodiment of the present invention, the cuvette buffer device 354 includes a cuvette buffer base 3541, a cuvette buffer turntable 3542 rotatably matched with the cuvette buffer base 3541, and a buffer rotation driving device 3543 for driving the cuvette buffer turntable 3542 to rotate, where the buffer rotation driving device 3543 may adopt a stepper motor; the reaction cup buffer turntable 3542 is provided with a plurality of reaction cup buffer parts 35421, each reaction cup buffer part 35421 is movably abutted against the outlet end 35321 of the discharge section 3532 of the guide channel 353, and along with the rotation of the reaction cup buffer turntable 3542, each reaction cup output from the outlet end 35321 of the discharge section 3532 of the guide channel 353 sequentially enters each reaction cup buffer part 35421. Further, the reaction cup buffering device 354 further includes a rotary encoder 3544 coaxially connected to the reaction cup buffering turntable 3542, and the rotary encoder 3544 can be used to control the rotation angle of the reaction cup buffering turntable 3542, so as to control the reaction cup buffering portion 35421 to accurately butt against the outlet end 35321 of the discharge section 3532 of the guide channel 353.
In the embodiment of the invention, each cuvette buffer portion 35421 of the cuvette buffer turntable 3542 is disposed at the periphery of the cuvette buffer turntable 3542, and the upper side and the outer side of the cuvette buffer portion 35421 are both disposed with openings; the cuvette buffer base 3541 has an annular retaining wall 35411 surrounding the cuvette buffer turntable 3542 to prevent the cuvette entering the cuvette buffer portion 35421 from falling out; the annular retaining wall 35411 is provided with a connection notch 35412 which is abutted against the outlet end 35321 of the discharging section 3532 of the guide channel 353, the connection notch 35412 is movably abutted against the outer opening of each reaction cup buffer portion 35421 to ensure that the reaction cup output by the discharging section 3532 of the guide channel 353 can enter the reaction cup buffer portion 35421, and the outlet end 35321 of the discharging section 3532 of the guide channel 353 can be inserted into the connection notch 35412 of the annular retaining wall 35411 to enable the reaction cup buffer base 3541 to support the guide channel 353, so that the guide channel 353 is more stable.
In an embodiment of the present invention, the cuvette automatic loading module 35 of the present invention further comprises a cuvette storage device 356 cooperating with the cuvette hopper 351, and the cuvette hopper 351 is replenished with a cuvette by the cuvette storage device 356. Specifically, the reaction cup storage device 356 includes a reaction cup bin 3561 and a feed supplement conveyor 3562; the reaction cup bin 3561 is matched with the upper part of the reaction cup hopper 351, one side of the reaction cup bin 3561 is provided with a feeding hole 35611 communicated with the inner cavity of the reaction cup hopper 351, the feeding hole 35611 is matched with an elastic baffle 3563, the feeding conveyer belt 3562 is matched with the reaction cup bin 3561 and the reaction cup hopper 351, and the upper side of a belt of the feeding conveyer belt 3562 is connected with the elastic baffle 3563. The reaction cup stock device 356 works in the following manner: in a normal state, reaction cups in the reaction cup storage 3561 are piled up on a belt of the feed-in conveyer belt 3562, when the reaction cups need to be fed into the reaction cup hopper 351, the feed-in conveyer belt 3562 operates to drive the reaction cups in the reaction cup storage 3561 to move and push the elastic baffle 3563 so that the elastic baffle 3563 deforms to open the feed-in port 35611, and thus the feed-in conveyer belt 3562 can drive the reaction cups to pass through the feed-in port 35611 and the reaction cups passing through the feed-in port 35611 enter the reaction cup hopper 351 under the drive of the feed-in conveyer belt 3562; when the feed conveyor 3562 is not in operation, the elastic baffle 3563 is reset to close the feed inlet 35611, so that the reaction cups in the reaction cup bin 3561 do not enter the reaction cup hopper 351.
In the embodiment of the invention, the reaction cup bin 3561 is provided with a bin alarm switch 35612 for monitoring whether the reaction cup in the reaction cup bin 3561 is sufficient; when the reaction cup in the reaction cup storage 3561 is insufficient, the storage alarm switch 35612 alarms to remind people to supplement the reaction cup to the reaction cup storage 3561. The bin alarm switch 35612 can be an infrared proximity switch, and when the reaction cup in the reaction cup bin 3561 can trigger the bin alarm switch 35612, the reaction cup in the reaction cup bin 3561 is monitored to be sufficient; and when the bin alarm switch 35612 can not be triggered, the shortage of the reaction cup in the reaction cup bin 3561 is monitored.
In the embodiment of the invention, a hopper feed-in switch 3511 for monitoring whether the reaction cup hopper 351 needs to be fed with the reaction cup is arranged in the reaction cup hopper 351, and the hopper feed-in switch 3511 controls whether the feed-in conveyer 3562 works or not; when the hopper feed supplement switch 3511 monitors that the reaction cup hopper 351 needs to be supplemented with a reaction cup, the hopper feed supplement switch 3511 controls the feed supplement conveyor 3562 to work, so that the reaction cup storage device 356 supplements the reaction cup to the reaction cup hopper 351. The hopper feed supplement switch 3511 may be an infrared switch, and when the reaction cup in the reaction cup hopper 351 can trigger the hopper feed supplement switch 3511, it is monitored that the reaction cup hopper 351 does not need to be supplemented with a reaction cup; and when the hopper feed switch 3511 is not triggered, the reaction cup hopper 351 is monitored to be required to replenish the reaction cup.
In an embodiment of the present invention, the first cuvette transfer unit 361 may include a first electric gripper 3611, a first cuvette lifting driving unit 3612 for driving the first electric gripper 3611 to lift, and a first cuvette translation driving unit 3613 for driving the first cuvette lifting driving unit 3612 to translate; the second cuvette transfer unit 362 may include a second electric gripper 3621, a second cuvette lifting drive unit 3622 for driving the second electric gripper 3621 to lift, and a second cuvette translation drive unit 3623 for driving the second cuvette lifting drive unit 3622 to translate; the third cuvette transfer unit 363 may include a third electric gripper 3631, a third cuvette lifting driving unit 3632 for driving the third electric gripper 3631 to lift, a third cuvette translation driving unit 3633 for driving the third cuvette lifting driving unit 3632 to translate, and a fourth cuvette translation driving unit 3634 for driving the third cuvette translation driving unit 3633 to translate, where a translation direction of the third cuvette lifting driving unit 3632 is intersected with a translation direction of the third cuvette translation driving unit 3633. The first electric clamping jaw 3611, the second electric clamping jaw 3621 and the third electric clamping jaw 3631 can clamp the reaction cup by controlling the clamping jaws to open so that the clamping jaws are abutted against the inner wall of the reaction cup, and the clamping manner can clamp the reaction cup more stably.
In the embodiment of the present invention, the detection unit 3 further includes a reagent placement device 39, the first primary reagent dispensing device C, the second primary reagent dispensing device D, and the secondary reagent dispensing device e are disposed around the reagent placement device 39, and the reagent placement device 39 is configured to provide different designs for the first primary reagent dispensing device C, the second primary reagent dispensing device D, and the secondary reagent dispensing device e; the reagent holding device 39 has at least two reagent holding rings which are arranged one above the other and can rotate, each reagent holding ring being used for holding at least one reagent. The first primary reagent dispensing device C, the second primary reagent dispensing device D, and the second reagent dispensing device e may be used according to detection requirements of different samples, and the first primary reagent dispensing device C, the second primary reagent dispensing device D, and the second reagent dispensing device e do not need to be used at the same time.
In the embodiment of the invention, the full-automatic chemiluminescence immunoassay analyzer further comprises a cleaning solution preparing device 6 and a waste solution collecting device 7 which are matched with the detection unit 3, wherein the cleaning solution preparing device 6 and the waste solution collecting device 7 are arranged on the detection frame 5, the cleaning solution preparing device 6 is used for providing cleaning solution to the cleaning device b of the detection unit 3, the needle washing cylinder 372 of the needle washing assembly 37 and the needle washing device 38, and the waste solution collecting device 7 is used for recovering waste solution output by the cleaning device b of the detection unit 3, the excitation device c, the needle washing cylinder 372 of the needle washing assembly 37 and the needle washing device 38.
In the embodiment of the present invention, the cleaning solution preparing apparatus 6 includes a deionized water storage container 61, a concentrated solution storage container 62, a cleaning solution storage container 63, a first peristaltic pump 64, a second peristaltic pump 65, a conductivity tester 66, and a preparing controller (not shown); the liquid inlet end and the liquid outlet end of the first peristaltic pump 64 are respectively connected with the deionized water storage container 61 and the cleaning liquid storage container 63; the liquid inlet end and the liquid outlet end of the second peristaltic pump 65 are respectively connected with the concentrated liquid storage container 62 and the cleaning liquid storage container 63; the conductivity tester 66 is engaged with the cleaning liquid storage container 63 and is used for testing the conductivity of the cleaning liquid contained in the cleaning liquid storage container 63; the liquid dispensing controller is electrically connected with the first peristaltic pump 64, the second peristaltic pump 65 and the conductivity tester 66 respectively, and the liquid dispensing controller can adopt a singlechip. The invention can realize the automatic configuration of the cleaning liquid through the cleaning liquid preparation device 6, and the working principle of the cleaning liquid preparation device 6 is as follows: the liquid preparation controller controls the first peristaltic pump 64 to convey deionized water contained in the deionized water storage container 61 to the cleaning liquid storage container 63 according to a preset amount, and the liquid preparation controller controls the second peristaltic pump 65 to convey concentrated liquid contained in the concentrated liquid storage container 62 to the cleaning liquid storage container 63 according to a preset amount, and deionized water entering the cleaning liquid storage container 63 is mixed with the concentrated liquid to form cleaning liquid; meanwhile, the liquid preparation controller also tests whether the conductivity of the cleaning liquid in the cleaning liquid storage container 63 reaches the standard through the conductivity tester 66, if the conductivity of the cleaning liquid in the cleaning liquid storage container 63 does not reach the standard, the liquid preparation controller controls the first peristaltic pump 64 to supplement the deionized water stored in the deionized water storage container 61 into the cleaning liquid storage container 63 until the conductivity of the cleaning liquid in the cleaning liquid storage container 63 reaches the standard. The cleaning liquid storage container 63 is respectively fed to the cleaning device b, the needle cleaning assembly 37 and the needle cleaning device 38 of the detecting unit 3 by different peristaltic pumps.
In the embodiment of the present invention, the cleaning solution preparing device 6 further includes a circulation heating device 67 matched with the cleaning solution storage container 63, the circulation heating device 67 is electrically connected with the solution preparing controller, and the cleaning solution storage container 63 is matched with a temperature sensor (not shown) electrically connected with the solution preparing controller; the invention can heat the cleaning liquid through the circulating heating device 67, thereby improving the cleaning effect of the cleaning liquid. Specifically, the circulation heating device 67 includes a circulation heater 671 and a circulation magnetic pump 672, the liquid inlet end of the circulation magnetic pump 672 is connected to the cleaning liquid storage container 63, the liquid inlet end of the circulation magnetic pump 672 is connected to the liquid inlet end of the circulation heater 671, and the liquid outlet end of the circulation heater 671 is connected to the cleaning liquid storage container 63; the circulating heater 671 and the circulating magnetic pump 672 are electrically connected with the liquid preparation controller; when the cleaning solution is required to be heated, the solution preparing controller controls the circulating heater 671 and the circulating magnetic pump 672 to work, the circulating magnetic pump 672 pumps the cleaning solution of the cleaning solution storage container 63 to the circulating heater 671 and then returns the cleaning solution to the cleaning solution storage container 63, and the circulating heater 671 heats the cleaning solution flowing through the circulating heater 671; when the liquid dispensing controller detects that the temperature of the cleaning liquid meets the requirement through the temperature sensor, the controller controls the circulating heater 671 and the circulating magnetic pump 672 to stop working.
In the embodiment of the present invention, the cleaning solution preparing apparatus 6 further includes a filling device 68 matched with the deionized water storage container 61, and the filling module is used for replenishing deionized water to the deionized water storage container 61. Specifically, the liquid adding device 68 includes a deionized water external connector 681, a liquid adding peristaltic pump 682, a first electromagnetic valve 683 and a second electromagnetic valve 684, wherein a liquid inlet end and a liquid outlet end of the first electromagnetic valve 683 are respectively connected with the deionized water external connector 681 and the cleaning liquid storage container 63, a liquid inlet end and a liquid outlet end of the first electromagnetic valve 683 are respectively connected with the liquid outlet end of the liquid adding peristaltic pump 682 and the cleaning liquid storage container 63, a liquid inlet end of the liquid adding peristaltic pump 682 is connected with the deionized water external connector 681, and the liquid adding peristaltic pump 682, the first electromagnetic valve 683 and the second electromagnetic valve 684 are respectively electrically connected with the liquid distribution controller; when the water supply pipeline connected with the deionized water external connector 681 for conveying the deionized water has water pressure, the first electromagnetic valve 683 is opened, the second electromagnetic valve 684 is closed, and the water supply pipeline is used for conveying the deionized water into the deionized water storage container 61 from the deionized water by the water pressure; when the water supply line connected to the deionized water external connection connector 681 for delivering deionized water has no water pressure, the first solenoid valve 683 is closed, the second solenoid valve 684 is opened, and the liquid feeding peristaltic pump 682 is operated to pump deionized water in the water supply line to the deionized water storage container 61.
In an embodiment of the present invention, a washing liquid processing apparatus of an immunoassay analyzer of the present invention further includes a waste liquid collecting device 7, and a user of the waste liquid collecting device 7 collects washing liquid that has been used. Specifically, the waste liquid collecting device 7 includes a waste liquid collecting container 71 and a multi-channel peristaltic pump 72 connected to the waste liquid collecting container 71, where the multi-channel peristaltic pump 72 can pump the waste liquid output from the cleaning device b, the excitation device c, the syringe 372 of the syringe assembly 37 and the syringe 38 of the detection unit 3 to the waste liquid collecting container 71.
The above examples and drawings are not intended to limit the form or form of the present invention, and any suitable variations or modifications thereof by those skilled in the art should be construed as not departing from the scope of the present invention.
Claims (27)
1. A full-automatic chemiluminescence immunoassay analyzer, which is characterized in that: the device comprises a sample injection unit, a sample conveying unit and a detection unit;
The sample conveying unit is matched with the sample feeding unit and used for conveying and transferring samples;
The detection unit comprises a primary reaction module, a secondary reaction module, a detection module, a first incubation module, a second incubation module, a reaction cup automatic loading module and a reaction cup transferring module;
The first-stage reaction module comprises a reaction cup circulation device, a sample dispensing device, a first-stage reagent dispensing device, a second-stage reagent dispensing device and a first-stage mixing device, wherein the reaction cup circulation device is used for controlling the reaction cup to circulate at a reaction cup inlet and outlet station, a sample dispensing station, a first reagent dispensing station, a second reagent dispensing station and a first-stage mixing station, and the sample dispensing device, the first-stage reagent dispensing device, the second-stage reagent dispensing device and the first-stage mixing device are respectively corresponding to the sample dispensing station, the first reagent dispensing station, the second reagent dispensing station and the first-stage mixing station;
The secondary reaction and detection module comprises a washing testing disc, a cleaning device, an excitation device, a photometry device, a secondary reagent dispensing device and a plurality of secondary mixing devices, wherein the cleaning device, the excitation device, the photometry device, the secondary reagent dispensing device and the secondary mixing devices are arranged around the washing testing disc; the washing and measuring optical disk is provided with a washing inner ring and a measuring outer ring which are mutually sleeved and can rotate;
The reaction cup transfer module comprises a first reaction cup transfer device, a second reaction cup transfer device and a third reaction cup transfer device, wherein the first reaction cup transfer device is used for transferring reaction cups at the reaction cup automatic loading module, the reaction cup inlet and outlet station, the first incubation module and the washing inner ring, the second reaction cup transfer device is used for transferring reaction cups at the washing inner ring, the second incubation module and the photometry outer ring, and the third reaction cup transfer device is used for transferring reaction cups at the photometry outer ring and the discarding station.
2. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 1, wherein: the reaction cup circulation device comprises a circulation base, a runway track, a circulation mounting jig, a flexible transmission device and a circulation positioning mechanism;
the runway-type track is arranged on the circulation base, and is provided with two opposite straight-line sections and two opposite arc sections, and two ends of the two arc sections are respectively connected through the two straight-line sections; the number of the circulation installation jigs is at least four, and each circulation installation jig is in sliding connection with the runway type track; the flexible transmission device is connected with each circulation installation jig and drives the circulation installation jigs to move along the runway track; the circulation positioning mechanism is movably positioned and matched with each circulation installation jig.
3. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 2, wherein: the circulation installation jig is provided with a jig positioning part, and the jig positioning part is provided with a positioning clamping groove; the circulation positioning mechanism comprises at least two circulation positioning devices, each circulation positioning device comprises a positioning shaft, a positioning driving motor for driving the positioning shaft to rotate and at least one positioning rod which is arranged on the positioning shaft and is intersected with the positioning shaft, and the positioning rods are movably clamped into positioning clamping grooves of the jig positioning parts of the circulation installation jig.
4. A full-automatic chemiluminescence immunoassay apparatus according to claim 3, wherein: the positioning clamping groove of the jig positioning part of the circulation installation jig is perpendicular to the runway type track, the jig positioning part is further provided with two inclined guide surfaces respectively connected with two sides of the positioning clamping groove, and the positioning shaft and the positioning rod of the circulation positioning device are perpendicular to each other.
5. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 1, wherein: the automatic reaction cup loading module comprises a reaction cup hopper, a guide channel, a reaction cup pulling device, a guide channel and a reaction cup caching device;
the reaction cup pulling device comprises a pulling disc rotatably arranged in a reaction cup hopper and a pulling rotation driving device for driving the pulling disc to rotate, at least one pulling claw is arranged on the periphery of the pulling disc, and a laterally convex grabbing hook is arranged at the end part of the pulling claw; the guide channel is arranged in the reaction cup hopper, the guide channel is provided with a feeding section and a discharging section which are communicated, the feeding section of the guide channel stretches into the reaction cup hopper, the feeding section of the guide channel is higher than the discharging section and the pulling disc, the feeding section is in an arc structure and is positioned on the rotating track of the grabbing hook, the lower side of the feeding section is provided with a feeding notch for the pulling claw and the grabbing hook of the pulling claw to enter and exit, and one side of the feeding notch penetrates through the inlet end of the feeding section; the reaction cup buffer device is connected with the outlet end of the discharging section of the guide channel.
6. An automated chemiluminescence immunoassay apparatus according to claim 5, wherein: the reaction cup caching device comprises a reaction cup caching base, a reaction cup caching rotary table in rotary fit with the reaction cup caching base, and a caching rotary driving device for driving the caching rotary table to rotate; the reaction cup buffer turntable is provided with a plurality of reaction cup buffer parts at the outlet end of the discharging section of the movable butt joint guide channel.
7. An automated chemiluminescence immunoassay according to claim 6, wherein: each reaction cup buffer part of the reaction cup buffer turntable is arranged at the periphery of the reaction cup buffer turntable, and the upper side and the outer side of the reaction cup buffer part are both provided with openings; the reaction cup buffering base is provided with an annular retaining wall surrounding the reaction cup buffering turntable, the annular retaining wall is provided with a connection notch for abutting against the outlet end of the discharging section of the guide channel, and the connection notch is movably abutted against the outer side opening of each reaction cup buffering part.
8. An automated chemiluminescence immunoassay according to claim 6, wherein: the reaction cup hopper is provided with at least one elastic poking plate which is higher than the rotation center of the poking plate, and the elastic poking plate is positioned on the rotation track of the grabbing hook and opposite to the feeding section of the guide channel.
9. An automated chemiluminescence immunoassay according to claim 6, wherein: the automatic reaction cup loading module further comprises a reaction cup storage device matched with the reaction cup hopper; the reaction cup storage device comprises a reaction cup storage bin and a feed supplementing conveyor belt; the reaction cup bin is matched with the upper part of the reaction cup hopper, one side of the reaction cup bin is provided with a feeding hole communicated with the inner cavity of the reaction cup hopper, the feeding hole is matched with an elastic baffle plate, the feeding conveyer belt is matched with the reaction cup bin and the reaction cup hopper, and the upper side of a belt of the feeding conveyer belt is connected with the elastic baffle plate.
10. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 1, wherein: the sample conveying unit comprises a sample conveying device, a recovery conveying device, an emergency conveying device and a conveying switching device for conveying samples between the sample conveying device and the recovery conveying device;
The sample injection unit comprises a common sample area, a recovery sample area, an emergency sample area, a sample buffer area and a sample transfer device; the sample transfer device is movably matched with the common sample area, the recovery sample area, the emergency sample area, the sample buffer area, the sample feeding and conveying device, the recovery and conveying device and the emergency conveying device and is used for transferring samples.
11. A full-automatic chemiluminescence immunoassay apparatus according to claim 10, wherein: the sample transfer device comprises a sample taking and placing device and a transfer translation driving device for driving the sample taking and placing device to translate;
the sample taking and placing device comprises a taking and placing track, a hooking device capable of translating along the taking and placing track, and a hooking translation driving device for driving the hooking device to translate along the taking and placing track; the picking and placing track and the hooking translation driving device are arranged on the transferring translation driving device;
The common sample area is provided with a common placing rail for being in butt joint with the taking and placing rail; the recovery sample area is provided with a common recovery track for being in butt joint with the picking and placing track, and the emergency sample area is provided with an emergency track for being in butt joint with the picking and placing track; the sample buffer has a buffer track for interfacing with a pick-and-place track.
12. A full-automatic chemiluminescence immunoassay apparatus according to claim 11, wherein: the hooking device comprises a hooking plate and a hooking plate motor for driving the hooking plate to rotate; the bottom side of the picking and placing track is provided with a movable opening for the hook plate to move; the bottoms of the common placing rail, the common recycling rail, the emergency rail and the cache rail are respectively provided with a movable opening for the hook plate to move.
13. A full-automatic chemiluminescence immunoassay apparatus according to claim 11, wherein: the sample feeding unit further comprises three connecting conveying devices which are respectively connected with the sample feeding conveying device, the recovery conveying device and the emergency conveying device, wherein the connecting conveying devices comprise connecting conveying rails which are used for being in butt joint with the picking and placing rails and connecting belt conveying devices which are arranged in the connecting conveying rails.
14. A full-automatic chemiluminescence immunoassay apparatus according to claim 13, wherein: the sample feeding conveying device comprises a sample feeding conveying rail and a sample feeding belt conveying device arranged in the sample feeding conveying rail; the recovery conveying device comprises a recovery conveying rail and a recovery belt conveying device arranged in the recovery conveying rail; the emergency conveying device comprises an emergency conveying track and an emergency belt conveying device arranged in the emergency conveying track; the conveying switching device comprises a switching frame and a switching translation driving device, wherein the switching frame is used for moving back and forth at the end parts of the sample feeding belt conveying device and the recycling belt conveying device, and the switching translation driving device is used for driving the switching frame to translate, and the switching frame is provided with a switching guide groove which is movably butted with the sample feeding conveying track and the recycling conveying track.
15. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 1, wherein: the primary mixing device and the secondary mixing device have the same structure;
The primary mixing device comprises a mixing bracket, a mixing motor, a transmission assembly, a rotating shaft and a mixing seat; the mixing bracket is provided with a limiting seat, the limiting seat is provided with a limiting hole penetrating up and down, and a limiting bearing is matched in the limiting hole; the mixing motor is arranged on the mixing bracket and positioned below the limiting seat, the mixing motor is in transmission connection with the rotating shaft through the transmission assembly, and the rotating shaft penetrates through the limiting bearing and is matched with the inner ring of the limiting bearing; the mixing seat is connected with the upper end of the rotating shaft, is eccentrically arranged with the rotating shaft and is positioned above the limiting seat.
16. A full-automatic chemiluminescence immunoassay apparatus according to claim 15, wherein: the transmission assembly comprises a transmission screw rod and a transmission nut; the transmission screw rod is connected with the mixing motor, the top of the transmission screw rod is matched with a limiting block, the transmission nut is in threaded connection with the transmission screw rod, the transmission nut can slide off freely on the transmission screw rod, the transmission nut is movably propped against the lower side of the limiting block and is coaxially connected with the rotating shaft, and the transmission screw rod is sleeved in the rotating shaft.
17. A full-automatic chemiluminescence immunoassay apparatus according to claim 15, wherein: the mixing seat is detachably connected with the upper end of the rotating shaft through a universal seat, the universal seat is rotatably connected with the mixing seat, and the universal seat is detachably connected with the upper end of the rotating shaft.
18. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 1, wherein: the detection unit further comprises a reagent placement device; the first primary reagent dispensing device, the second primary reagent dispensing device and the secondary reagent dispensing device are arranged around the reagent placing device, and the reagent placing device is provided with at least two reagent placing rings which are mutually sleeved and can rotate.
19. A full-automatic chemiluminescence immunoassay apparatus according to claim 1 or 18, wherein: the first primary reagent dispensing device, the second primary reagent dispensing device and the second secondary reagent dispensing device have the same structure;
The first primary reagent dispensing device comprises a reagent dispensing head, a reagent dispensing needle arranged on the reagent dispensing head, a reagent dispensing rotary driving device for driving the reagent dispensing head to rotate, and a reagent dispensing lifting driving device for driving the reagent dispensing rotary driving device to lift; the reagent dispensing needle can be arranged on the reagent dispensing head in a vertically movable mode, a reset spring is arranged between the reagent dispensing needle and the reagent dispensing head, and a reagent dispensing needle proximity switch for detecting whether the reagent dispensing needle is shifted is arranged on the reagent dispensing head.
20. A full-automatic chemiluminescence immunoassay apparatus according to claim 19, wherein: the detection unit further comprises three needle washing devices which are respectively matched with the first primary reagent dispensing device, the second primary reagent dispensing device and the second secondary reagent dispensing device in a corresponding manner; the needle washing device is provided with a washing channel which is vertically communicated, the upper end of the washing channel is provided with a needle inlet hole, the lower end of the needle washing channel is provided with a waste liquid hole, the needle washing cylinder is also provided with at least one liquid inlet hole communicated with the needle washing channel, and the liquid inlet hole is used for inputting washing liquid.
21. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 1, wherein: the sample dispensing device comprises a sample dispensing head, a sample dispensing needle arranged on the sample dispensing head, a sample dispensing rotary driving device for driving the sample dispensing head to rotate, and a sample dispensing lifting driving device for driving the sample dispensing rotary driving device to lift; the sample dispensing needle can be arranged on the sample dispensing head in a vertically movable mode, a reset spring is arranged between the sample dispensing needle and the sample dispensing head, and a sample dispensing needle proximity switch for detecting whether the sample dispensing needle is shifted is arranged on the sample dispensing head.
22. A full-automatic chemiluminescence immunoassay apparatus according to claim 21, wherein: the detection unit further comprises a needle washing assembly correspondingly matched with the sample dispensing device; the needle washing assembly comprises a washing frame, a washing needle cylinder matched with the washing frame and a cleaning agent container for containing cleaning agent; the needle washing cylinder is provided with a needle washing channel which is vertically communicated, the upper end of the needle washing channel is provided with a needle inlet, the lower end of the needle washing channel is provided with a waste liquid outlet, and the needle washing cylinder is also provided with at least one liquid inlet communicated with the needle washing channel, and the liquid inlet is used for inputting cleaning liquid.
23. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 1, wherein: the device also comprises a cleaning liquid preparation device and a waste liquid collection device which are matched with the detection unit, wherein the cleaning liquid preparation device is used for providing cleaning liquid for the detection unit, and the waste liquid collection device is used for recycling waste liquid output by the detection unit;
The cleaning liquid preparation device comprises a deionized water storage container, a concentrated liquid storage container, a cleaning liquid storage container, a first peristaltic pump, a second peristaltic pump, a conductivity tester and a liquid preparation controller; the liquid inlet end and the liquid outlet end of the first peristaltic pump are respectively connected with the deionized water storage container and the cleaning liquid storage container; the liquid inlet end and the liquid outlet end of the second peristaltic pump are respectively connected with the concentrated liquid storage container and the cleaning liquid storage container; the conductivity tester is matched with the cleaning liquid storage container and used for testing the conductivity of the cleaning liquid contained in the cleaning liquid storage container; the liquid distribution controller is electrically connected with the first peristaltic pump, the second peristaltic pump and the conductivity tester respectively;
The waste liquid storage module comprises a waste liquid collection container and a multichannel peristaltic pump connected with the waste liquid collection container.
24. A full-automatic chemiluminescence immunoassay apparatus according to claim 23, wherein: the cleaning liquid preparation device also comprises a circulating heating device matched with the cleaning liquid storage container, the circulating heating device is electrically connected with the liquid preparation controller, and the cleaning liquid storage container is matched with a temperature sensor electrically connected with the liquid preparation controller;
The circulating heating device comprises a circulating heater and a circulating magnetic pump, wherein the liquid inlet end of the circulating magnetic pump is connected with the cleaning liquid storage container, the liquid inlet end of the circulating magnetic pump is connected with the liquid inlet end of the circulating heater, and the liquid outlet end of the circulating heater is connected with the cleaning liquid storage container; the circulating heater and the circulating magnetic pump are electrically connected with the liquid distribution controller.
25. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 1, wherein: the excitation device comprises an excitation head and an excitation lifting driving device for driving the excitation head to lift; the excitation head is provided with a pre-excitation liquid dispensing needle, an excitation liquid dispensing needle and a waste liquid sucking needle.
26. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 1, wherein: the cleaning device comprises a cleaning head and a cleaning lifting driving device for driving the cleaning head to lift; the cleaning head is provided with two cleaning units, and each cleaning unit is provided with at least one cleaning liquid dispensing needle and at least one waste liquid drawing needle.
27. A full-automatic chemiluminescence immunoassay analyzer as set forth in claim 1, wherein: the sample injection unit is arranged on the sample injection rack; the sample conveying unit and the detection unit are arranged on the detection rack; the sample feeding rack and the detection mechanism are close together.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410400593.4A CN118259036A (en) | 2024-04-03 | 2024-04-03 | Full-automatic chemiluminescence immunoassay instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410400593.4A CN118259036A (en) | 2024-04-03 | 2024-04-03 | Full-automatic chemiluminescence immunoassay instrument |
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| Publication Number | Publication Date |
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| CN118259036A true CN118259036A (en) | 2024-06-28 |
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|---|---|---|---|
| CN202410400593.4A Pending CN118259036A (en) | 2024-04-03 | 2024-04-03 | Full-automatic chemiluminescence immunoassay instrument |
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| Country | Link |
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| CN (1) | CN118259036A (en) |
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- 2024-04-03 CN CN202410400593.4A patent/CN118259036A/en active Pending
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