CN118202068A - 检测rna生物标志物的方法 - Google Patents

检测rna生物标志物的方法 Download PDF

Info

Publication number
CN118202068A
CN118202068A CN202280074110.5A CN202280074110A CN118202068A CN 118202068 A CN118202068 A CN 118202068A CN 202280074110 A CN202280074110 A CN 202280074110A CN 118202068 A CN118202068 A CN 118202068A
Authority
CN
China
Prior art keywords
cancer
rna
expression
itf3756
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280074110.5A
Other languages
English (en)
Chinese (zh)
Inventor
G·福萨蒂
C·里帕蒙蒂
C·施泰因屈勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Italfarmaco SpA
Original Assignee
Italfarmaco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco SpA filed Critical Italfarmaco SpA
Publication of CN118202068A publication Critical patent/CN118202068A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2561/00—Nucleic acid detection characterised by assay method
    • C12Q2561/101—Taqman
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202280074110.5A 2021-11-23 2022-11-22 检测rna生物标志物的方法 Pending CN118202068A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT202100029558 2021-11-23
IT102021000029558 2021-11-23
PCT/EP2022/082762 WO2023094365A1 (en) 2021-11-23 2022-11-22 Method to detect rna biomarkers

Publications (1)

Publication Number Publication Date
CN118202068A true CN118202068A (zh) 2024-06-14

Family

ID=80121649

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280074110.5A Pending CN118202068A (zh) 2021-11-23 2022-11-22 检测rna生物标志物的方法

Country Status (9)

Country Link
US (1) US20250011878A1 (enExample)
EP (1) EP4437138A1 (enExample)
JP (1) JP2024543138A (enExample)
KR (1) KR20240105468A (enExample)
CN (1) CN118202068A (enExample)
AR (1) AR127708A1 (enExample)
CA (1) CA3235259A1 (enExample)
TW (1) TW202340480A (enExample)
WO (1) WO2023094365A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025080842A1 (en) * 2023-10-11 2025-04-17 Dana-Farber Cancer Institute, Inc. Methods of cancer detection, prediction of response to therapy, and treatment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012018499A2 (en) * 2010-08-05 2012-02-09 Acetylon Pharmaceuticals Specific regulation of cytokine levels by hdac6 inhibitors
US20120176076A1 (en) 2011-01-10 2012-07-12 Carl Mansfield Methods and systems for powering auxiliary devices in photovol taic system
WO2014032899A1 (en) * 2012-08-31 2014-03-06 Novo Nordisk A/S Diagnosis and treatment of lupus nephritis
EP3084446B1 (en) * 2013-12-20 2022-12-14 Acetylon Pharmaceuticals, Inc. Histone deacetylase 6 (hdac6) biomarkers in multiple myeloma
CA2995520A1 (en) * 2015-08-14 2017-02-23 Hendrik Jan VAN OOIJEN Assessment of nfkb cellular signaling pathway activity using mathematical modelling of target gene expression
WO2017070441A1 (en) * 2015-10-23 2017-04-27 Icahn School Of Medicine At Mount Sinai Identifying and treating cancer patients who are suitable for a targeted therapy using an hdac6 inhibitor
IT201700041723A1 (it) 2017-04-14 2018-10-14 Italfarmaco Spa Nuovi inibitori selettivi di HDAC6

Also Published As

Publication number Publication date
JP2024543138A (ja) 2024-11-19
CA3235259A1 (en) 2023-06-01
US20250011878A1 (en) 2025-01-09
WO2023094365A1 (en) 2023-06-01
TW202340480A (zh) 2023-10-16
KR20240105468A (ko) 2024-07-05
EP4437138A1 (en) 2024-10-02
AR127708A1 (es) 2024-02-21

Similar Documents

Publication Publication Date Title
McAllan et al. Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes
AU2019203513A1 (en) Urine biomarker cohorts, gene expression signatures, and methods of use thereof
Malaab et al. Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis
Sharma et al. Genome-wide ChIP-seq analysis of EZH2-mediated H3K27me3 target gene profile highlights differences between low-and high-grade astrocytic tumors
KR102029775B1 (ko) 비근침윤성 방광암 진단용 바이오마커 및 이의 용도
Dini et al. Kinetics of the chromosome 14 microRNA cluster ortholog and its potential role during placental development in the pregnant mare
EP2643478B1 (en) Methods for selecting competent oocytes and competent embryos with high potential for pregnancy outcome
US20170058348A1 (en) Predictive mRNA Biomarkers for the Prediction of the Treatment with Methotrexate (MTX)
Sun et al. LncRNAs induce oxidative stress and spermatogenesis by regulating endoplasmic reticulum genes and pathways
Rodríguez-Vicente et al. MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL
CN111630182A (zh) 用于治疗类风湿性关节炎(ra)的诊断和治疗方法
Bhan et al. Global gene expression analysis reveals specific and redundant roles for H1 variants, H1c and H10, in gene expression regulation
Kang et al. MiR‐543 regulates myoblast proliferation and differentiation of C2C12 cells by targeting KLF6
US11359245B2 (en) Method for determining decrease in functions of hippocampus by using correlation between micro RNA and NMDA receptor, method for inhibiting decrease in functions, and method for screening for inhibitors of decrease in functions
Jensen et al. A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C
Chen et al. miRNA-mRNA analysis of sheep adrenal glands reveals the network regulating reproduction
CN118202068A (zh) 检测rna生物标志物的方法
WO2010066891A2 (en) Method for predicting the response to treatment by tyrosine kinase inhibitors targeting the bcr-abl fusion protein in chronic myeloid leukaemia patients
van der Linden et al. Inhibition of methylation and changes in gene expression in relation to neural tube defects
Kharlap et al. Atrial appendage transcriptional profile in patients with atrial fibrillation with structural heart diseases
Bennett et al. Micro RNA’s (mirna’s) may help explain expression of multiple genes in Alzheimer’s frontal cortex
Saini et al. Impact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblasts
Baek et al. Assessment of XCI skewing and demonstration of XCI escape region based on single-cell RNA sequencing: comparison between female Grave’s disease and control
EP3255433A1 (en) Methods using blm as a marker of multiple myeloma
Mashreghi et al. THU0467 Silencing of the MEFV Gene in Familial Mediterranean Fever and Transcriptomic Analysis in Human Monocytes: Evidence for the Involvement of Pyrin in Innate Immune Responses and Autophagy

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination