AR127708A1 - Método para detectar biomarcadores de arn - Google Patents
Método para detectar biomarcadores de arnInfo
- Publication number
- AR127708A1 AR127708A1 ARP220103170A ARP220103170A AR127708A1 AR 127708 A1 AR127708 A1 AR 127708A1 AR P220103170 A ARP220103170 A AR P220103170A AR P220103170 A ARP220103170 A AR P220103170A AR 127708 A1 AR127708 A1 AR 127708A1
- Authority
- AR
- Argentina
- Prior art keywords
- hdac6
- tetrazol
- thiophen
- benzamide
- inhibitors
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 102000011427 Histone Deacetylase 6 Human genes 0.000 abstract 4
- 108010023925 Histone Deacetylase 6 Proteins 0.000 abstract 4
- 230000014509 gene expression Effects 0.000 abstract 4
- 239000003112 inhibitor Substances 0.000 abstract 4
- 101001134216 Homo sapiens Macrophage scavenger receptor types I and II Proteins 0.000 abstract 2
- 102100025354 Macrophage mannose receptor 1 Human genes 0.000 abstract 2
- 102100034184 Macrophage scavenger receptor types I and II Human genes 0.000 abstract 2
- UFUGFWWXDWPEQE-UHFFFAOYSA-N N-hydroxy-4-[(5-thiophen-2-yltetrazol-1-yl)methyl]benzamide Chemical compound ONC(C1=CC=C(C=C1)CN1N=NN=C1C=1SC=CC=1)=O UFUGFWWXDWPEQE-UHFFFAOYSA-N 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 102100036664 Adenosine deaminase Human genes 0.000 abstract 1
- 102100034278 Annexin A6 Human genes 0.000 abstract 1
- 102100039398 C-X-C motif chemokine 2 Human genes 0.000 abstract 1
- 102100036189 C-X-C motif chemokine 3 Human genes 0.000 abstract 1
- 108010009992 CD163 antigen Proteins 0.000 abstract 1
- 102100038078 CD276 antigen Human genes 0.000 abstract 1
- 101150013553 CD40 gene Proteins 0.000 abstract 1
- 101000929495 Homo sapiens Adenosine deaminase Proteins 0.000 abstract 1
- 101000780137 Homo sapiens Annexin A6 Proteins 0.000 abstract 1
- 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 abstract 1
- 101000947193 Homo sapiens C-X-C motif chemokine 3 Proteins 0.000 abstract 1
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 abstract 1
- 101001011446 Homo sapiens Interferon regulatory factor 6 Proteins 0.000 abstract 1
- 101000978212 Homo sapiens Latent-transforming growth factor beta-binding protein 4 Proteins 0.000 abstract 1
- 101000685655 Homo sapiens Long-chain fatty acid transport protein 1 Proteins 0.000 abstract 1
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 abstract 1
- 101000962052 Homo sapiens Neurobeachin-like protein 2 Proteins 0.000 abstract 1
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 abstract 1
- 101000832225 Homo sapiens Stabilin-1 Proteins 0.000 abstract 1
- 102100030130 Interferon regulatory factor 6 Human genes 0.000 abstract 1
- 102100023757 Latent-transforming growth factor beta-binding protein 4 Human genes 0.000 abstract 1
- 102100023111 Long-chain fatty acid transport protein 1 Human genes 0.000 abstract 1
- 108010031099 Mannose Receptor Proteins 0.000 abstract 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100039235 Neurobeachin-like protein 2 Human genes 0.000 abstract 1
- -1 RANK / TNFRSF11a Proteins 0.000 abstract 1
- 102100029216 SLAM family member 5 Human genes 0.000 abstract 1
- 102100025831 Scavenger receptor cysteine-rich type 1 protein M130 Human genes 0.000 abstract 1
- 102100024471 Stabilin-1 Human genes 0.000 abstract 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000013074 reference sample Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2561/00—Nucleic acid detection characterised by assay method
- C12Q2561/101—Taqman
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT202100029558 | 2021-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR127708A1 true AR127708A1 (es) | 2024-02-21 |
Family
ID=80121649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220103170A AR127708A1 (es) | 2021-11-23 | 2022-11-17 | Método para detectar biomarcadores de arn |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250011878A1 (enExample) |
| EP (1) | EP4437138A1 (enExample) |
| JP (1) | JP2024543138A (enExample) |
| KR (1) | KR20240105468A (enExample) |
| CN (1) | CN118202068A (enExample) |
| AR (1) | AR127708A1 (enExample) |
| CA (1) | CA3235259A1 (enExample) |
| TW (1) | TW202340480A (enExample) |
| WO (1) | WO2023094365A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025080842A1 (en) * | 2023-10-11 | 2025-04-17 | Dana-Farber Cancer Institute, Inc. | Methods of cancer detection, prediction of response to therapy, and treatment |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012018499A2 (en) * | 2010-08-05 | 2012-02-09 | Acetylon Pharmaceuticals | Specific regulation of cytokine levels by hdac6 inhibitors |
| US20120176076A1 (en) | 2011-01-10 | 2012-07-12 | Carl Mansfield | Methods and systems for powering auxiliary devices in photovol taic system |
| WO2014032899A1 (en) * | 2012-08-31 | 2014-03-06 | Novo Nordisk A/S | Diagnosis and treatment of lupus nephritis |
| EP3084446B1 (en) * | 2013-12-20 | 2022-12-14 | Acetylon Pharmaceuticals, Inc. | Histone deacetylase 6 (hdac6) biomarkers in multiple myeloma |
| CA2995520A1 (en) * | 2015-08-14 | 2017-02-23 | Hendrik Jan VAN OOIJEN | Assessment of nfkb cellular signaling pathway activity using mathematical modelling of target gene expression |
| WO2017070441A1 (en) * | 2015-10-23 | 2017-04-27 | Icahn School Of Medicine At Mount Sinai | Identifying and treating cancer patients who are suitable for a targeted therapy using an hdac6 inhibitor |
| IT201700041723A1 (it) | 2017-04-14 | 2018-10-14 | Italfarmaco Spa | Nuovi inibitori selettivi di HDAC6 |
-
2022
- 2022-11-16 TW TW111143736A patent/TW202340480A/zh unknown
- 2022-11-17 AR ARP220103170A patent/AR127708A1/es unknown
- 2022-11-22 WO PCT/EP2022/082762 patent/WO2023094365A1/en not_active Ceased
- 2022-11-22 US US18/711,937 patent/US20250011878A1/en active Pending
- 2022-11-22 JP JP2024531107A patent/JP2024543138A/ja active Pending
- 2022-11-22 CN CN202280074110.5A patent/CN118202068A/zh active Pending
- 2022-11-22 KR KR1020247020263A patent/KR20240105468A/ko active Pending
- 2022-11-22 EP EP22821454.0A patent/EP4437138A1/en active Pending
- 2022-11-22 CA CA3235259A patent/CA3235259A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024543138A (ja) | 2024-11-19 |
| CA3235259A1 (en) | 2023-06-01 |
| US20250011878A1 (en) | 2025-01-09 |
| WO2023094365A1 (en) | 2023-06-01 |
| TW202340480A (zh) | 2023-10-16 |
| CN118202068A (zh) | 2024-06-14 |
| KR20240105468A (ko) | 2024-07-05 |
| EP4437138A1 (en) | 2024-10-02 |
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