CN118178258B - Sun-screening composition containing photo-lyase and collagen, and preparation method and application thereof - Google Patents
Sun-screening composition containing photo-lyase and collagen, and preparation method and application thereof Download PDFInfo
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- CN118178258B CN118178258B CN202410591317.0A CN202410591317A CN118178258B CN 118178258 B CN118178258 B CN 118178258B CN 202410591317 A CN202410591317 A CN 202410591317A CN 118178258 B CN118178258 B CN 118178258B
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- collagen
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- water
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Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/496—Triazoles or their condensed derivatives, e.g. benzotriazoles
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention belongs to the technical field of biology, and particularly relates to a sun-screening composition containing photo-lyase and collagen, and a preparation method and application thereof. The invention provides a sun-proof composition which comprises the following components in percentage by mass: 0.01-5% of photo-lyase, 0.01-5% of collagen, 20-50% of sun-screening agent, 20.91-53.6% of auxiliary material, the balance of deionized water and the like; wherein, the collagen is composed of type I collagen, type III collagen and other collagens according to the mass ratio of 12-15: 1-5: 87-80. The invention provides a composition containing photo-lyase and collagen to synergistically enhance sun-screening performance by combining the function of repairing DNA with the performance of collagen film formation on the skin surface. The composition provided by the invention has the effect of relieving, is not greasy in skin feel and easy to apply, can be used for preparing various cosmetics such as cream, emulsion, essence and the like, and has a very wide application range.
Description
Technical Field
The invention belongs to the technical field of biology, and particularly relates to a sun-screening composition containing photo-lyase and collagen, and a preparation method and application thereof.
Background
Ultraviolet rays in sunlight have a damaging effect on human skin. Ultraviolet rays are divided into 4 different wavelengths according to biological effects, namely, UVA wave band (320-400 nm), UVB wave band (280-320 nm), UVC wave band (200-275 nm) and UVD wave band (100-200 nm). Mainly the ultraviolet rays in UVA and UVB wave bands cause damage to the skin. The ultraviolet rays in the UVA wave band have strong penetrating power, can reach the dermis layer of the skin, and can cause skin tanning. The ultraviolet rays in the UVB wave band have moderate penetrability, and can lead to skin redness and sunburn. Sun protection products against UVA and UVB are important.
At present, a lot of sun-screening products are on the market, and in many formulas, physical sun-screening powder is matched with various chemical sun-screening agents to realize sun-screening effect, but the raw materials of the physical sun-screening agents have the problems of whitening, difficult dispersion in the formulas, difficult smearing and the like. The chemical sun-screening agent has the problems of oily skin feel, easy precipitation of the solid chemical sun-screening agent in the later period, and the like. When the sun protection agent is researched, the chemical sun protection agent and the physical sun protection agent are reasonably matched, so that the effects of easiness in smearing on skin feel, easiness in dispersing and applying in a formula, small addition amount of the sun protection agent and high sun protection index are finally achieved.
Chinese patent application CN115813793a discloses a sunscreen composition comprising a main sunscreen agent and a grease, the main sunscreen agent being a combination of bis-ethylhexyloxyphenol methoxyphenyl triazine and ethylhexyl triazone, the grease being a grease which does not contain phenyl groups and has a dielectric constant of less than 3. Although the final product has the effects of safety, simplicity, stability and the like, the sun-screening composition contains a large amount of grease, and can cause the defects of greasy skin feel and difficult dispersion when being smeared on skin, thereby affecting the sun-screening effect.
Chinese patent application CN114828804a discloses a sunscreen composition, specifically comprising a lipophilic organic UV filter and silica spherical particles, wherein the lipophilic organic UV filter is selected from aminobenzophenone compounds, salicylic acid compounds, β, β -diphenylacrylate compounds, benzotriazole compounds, and the like, and finally exhibits a good UV filtering effect. However, such a sunscreen composition only proves to have a good sunscreen effect within 15 minutes, and the long-lasting effect of the sunscreen effect cannot be ensured.
In summary, the existing sun-screening agents have short sun-screening time and poor effect, and the formulas of the sun-screening products on the market are not matched well, so that the sun-screening products cause skin irritation and allergy, and therefore, the development of sun-screening products with the effects of relieving and lasting sun-screening effect is important.
Disclosure of Invention
In view of the problems generally existing in the prior art, the invention provides a sunscreen composition which has a soothing effect, is not greasy in skin feel, is easy to apply, does not cause irritation reaction to skin, and can be used in the preparation process of various skin care products.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
A sunscreen composition comprising photo-lyase and collagen, comprising the following components in percentage by mass: 0.01-5% of photo-lyase, 0.01-5% of collagen, 10-40% of sun-screening agent, 20.91-53.6% of auxiliary material and the balance of deionized water.
Preferably, the sun-proof composition comprises the following components in percentage by mass: 4% of photo-lyase, 4% of collagen, 33% of sun-screening agent, 40.1% of auxiliary material and the balance of deionized water.
Preferably, the sunscreens include water-soluble sunscreens and oil-soluble sunscreens, wherein the water-soluble sunscreens include phenylbenzimidazole sulfonic acid and methylenebis-benzotriazole-tetramethylbutylphenol; oil-soluble sunscreens include ethylhexyl triazone, bis-ethylhexyl oxyphenol methoxyphenyl triazine and titanium dioxide.
Preferably, the sun-screening agent is prepared from phenylbenzimidazole sulfonic acid, ethylhexyl triazone, bis-ethylhexyl oxyphenol methoxyphenyl triazine, methylene bis-benzotriazole tetramethylbutylphenol and titanium dioxide according to a mass ratio of 3-8:3-8:3-8:1-8: 1-5.
Preferably, the collagen is composed of type I collagen, type III collagen and other collagen according to a mass ratio of 12-15: 1-5: 87-80 parts; the other collagen is one or more of type II collagen, type XI collagen, type XXIV collagen and type XXVII collagen.
Collagen is available from a variety of sources, most of which are from animals, but the type III and type I collagen currently in common use are relatively expensive, limiting their use in sunscreen products, and other collagens that can replace both of these collagens have not been found in the prior art. Based on the above, the invention is researched and researched in a large number, and the invention discovers that the type I collagen and the type III collagen are mixed with the type II collagen, the type XI collagen, the type XXIV collagen and the type XXVII collagen, so that the action effect of the type I collagen and the type III collagen can be achieved, and the type I collagen and the type III collagen are low in cost.
Preferably, the auxiliary materials comprise the following components in percentage by mass in the sun-screening composition: 1-3% of humectant, 0.01-0.1% of chelating agent, 10-20% of emollient, 0.1-1% of skin conditioner, 0.5-1% of preservative, 5-15% of emulsifier, 5-12% of thickener and 0.3-1.5% of pH regulator.
Preferably, the emulsifier comprises a water-soluble emulsifier and an oil-soluble emulsifier, wherein the water-soluble emulsifier is one or more of disodium cetylstearyl sulfosuccinate, and the oil-soluble emulsifier is one or more of steareth-2, steareth-21, arachidyl glucoside, PEG-100 stearate, glycerol stearate, cetylstearyl glucoside, sodium stearyl glutamate, disodium cetylstearyl sulfosuccinate, cetyl PEG/PPG-10/1 polydimethylsiloxane, PEG-10 polydimethylsiloxane, PEG-9 polydimethylsiloxane ethyl polydimethylsiloxane, sorbitan oleate, and sorbitan stearate; the thickener comprises a water-soluble thickener and an oil-soluble thickener, wherein the water-soluble thickener is one or more of xanthan gum, carbomer, hydroxyethyl cellulose and acrylic acid (esters) of C10-30 alkanol acrylate crosslinked polymers; the oil-soluble thickener is one of paraffin, beeswax, carnauba wax, bentonite and disteardimonium hectorite.
Preferably, the humectant is one or more of glycerol, propylene glycol, 1, 3-propylene glycol, butylene glycol, pentylene glycol, glycereth-26, saccharide isomer, hexylene glycol, octylene glycol, betaine, allantoin, trehalose; the chelating agent is one of disodium EDTA and tetrasodium EDTA; the emollient is one or more of diisopropyl sebacate, squalane, caprylic/capric triglyceride, ceramide NP, phosphatidylcholine, butter tree (BUTYROSPERMUM PARKII) fruit fat, isohexadecane, silicone oil, olive oil, ethylhexyl palmitate, and jojoba ester oil; the preservative is one or more of methylparaben, propylparaben, phenoxyethanol, anisic acid, dehydroacetic acid, benzyl alcohol and iodopropynyl butyl carbamate; the pH regulator is one of arginine, citric acid, sodium citrate, sodium hydroxide and potassium hydroxide; the skin conditioning agents are water soluble and include, but are not limited to, centella asiatica (CENTELLA ASIATICA) extracts, madecassoside, cynomorium songaricum (CYNANCHUM ATRATUM) extracts, citrus (CITRUS RETICULATA) pericarp extracts, carnosine, glutathione, kava (PIPER METHYSTICUM) root extracts, gluconolactone, salicylic acid, azelaic acid, p-hydroxyacetophenone, and the like.
The invention also provides a preparation method of the sun-proof composition, which comprises the following steps:
S1, adding deionized water, a humectant, a chelating agent, a skin conditioning agent, a water-soluble emulsifying agent, a water-soluble thickening agent and 1/2 water-soluble sun-screening agent into a water phase pot, starting stirring, heating to 80-85 ℃, and uniformly dispersing to obtain a phase A;
S2, adding an emollient, an oil-soluble emulsifier, an oil-soluble thickener and an oil-soluble sun-screening agent into an oil phase pot, heating to 80-85 ℃, and uniformly stirring and dispersing to obtain a phase B;
s3, pumping the phase A in the step S1 and the phase B in the step S2 into an emulsifying pot, homogenizing at a high speed, stirring uniformly, and cooling to 60-65 ℃ to obtain a mixture I;
s4, adding a preservative and a pH regulator into the mixture I prepared in the step S3, uniformly stirring, and homogenizing for 3-8min; stirring and cooling to 40-45 ℃ to obtain a mixture II;
and S5, adding the rest water-soluble sun-screening agent, collagen and photo-lyase into the mixture II prepared in the step S4, uniformly stirring, detecting to be qualified, and discharging to obtain the product.
The invention also provides application of the sun-screening composition in preparing skin care products.
Photo-lyase is an enzyme capable of repairing DNA, and can repair pyrimidine dimers formed by light damage by absorbing UVA energy, and has the effects of absorbing ultraviolet rays and repairing skin when being used in sun-screening products. However, the prior art has little research on the performance of photo-lyase on human skin. In the research process of each component of the sun-screening agent, the existence of the photo-lyase can reduce the expression of matrix metalloproteinase, avoid the loss of collagen, help to promote the bioactivity of mixed collagen, accelerate the formation of a protective film, and synergistically increase the two, so that the prepared sun-screening composition still has good sun-screening effect after 24 hours, and effectively improves the sun-screening performance of the sun-screening composition, besides repairing DNA and absorbing ultraviolet rays. The invention selects benzene benzimidazole sulfonic acid, ethylhexyl triazone, bis-ethylhexyl oxyphenol methoxyphenyl triazone, methylene bis-benzotriazole tetramethyl butyl phenol and titanium dioxide according to the mass ratio of 3-8:3-8:3-8:1-8:1-5, and controlling the sun-screening dosage within 10-40%, can increase the skin feel effect of the sun-screening composition, and is easy to apply and not greasy.
Compared with the prior art, the invention has the following advantages: according to the sun-screening composition provided by the invention, the composition still has a good sun-screening effect after 24 hours through the synergistic effect of the photo-lyase and the collagen. Meanwhile, the sun-screening composition provided by the invention also has a soothing effect, is not greasy in skin feel and is easy to apply.
Detailed Description
The present invention will be further explained with reference to specific examples, but it should be noted that the following examples are only for explaining the present invention, and are not intended to limit the present invention, and all technical solutions identical or similar to the present invention are within the scope of the present invention. The specific techniques or conditions are not noted in this example and are practiced according to methods and apparatus conventional in the art; the reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
The centella asiatica (CENTELLA ASIATICA) Extract is available from Guangzhou Yujin trade company, model CENTELLA ASIATIC Extract centella asiatica Extract; the cynanchum atratum (CYNANCHUM ATRATUM) extract is available from Shanghai Reidian biotechnology Co., ltd, model HI-CLERA (PF); the citrus (CITRUS RETICULATA) peel extract is available from ICHIMARU PHARCOS Co., ltd., model MANDARINCLEAR; the kava (PIPER METHYSTICUM) root extract is available from the western amp green biotechnology company under the model DCR516. Carnosine is available from Vichi technologies Inc. of Dongguan, model number WKPep Carnosine.
Examples the components of examples 1-5 were formulated as in table 1 below.
TABLE 1 content of the components in examples 1 to 5
The preparation method of the sun-screening composition comprises the following steps:
s1, adding deionized water, a humectant, a chelating agent, a water-soluble skin conditioning agent, a water-soluble emulsifying agent, a water-soluble thickening agent, a part of water-soluble sun-screening agent and a water phase pot, starting stirring, heating to 80-85 ℃, and uniformly dispersing to obtain a phase A;
s2, adding an emollient, an oil-soluble skin conditioner, an oil-soluble emulsifier, an oil-soluble thickener and an oil-soluble sun-screening agent into an oil phase pot, heating to 80-85 ℃, and uniformly stirring and dispersing to obtain a phase B;
S3, pumping the phase A in the step S1 and the phase B in the step S2 into an emulsifying pot, homogenizing at a high speed for 5min, stirring uniformly, opening the emulsifying pot to cool circulating water, and stirring and cooling to 60-65 ℃ to obtain a mixture I;
s4, adding a preservative and a pH regulator into the mixture I prepared in the step S3, uniformly stirring, and homogenizing for 3-8min; cooling circulating water in an emulsifying pot, stirring and cooling to 40-45 ℃ to obtain a mixture II;
And S5, adding the rest water-soluble sun-screening agent into the mixture II prepared in the step S4, uniformly stirring collagen and photo-lyase, detecting to be qualified, and discharging to obtain the product.
Comparative example 1A sunscreen composition
The sunscreen composition was similar to example 2;
the difference from example 2 is that photo-lyase and collagen were not added in comparative example 1. Deionized water was added to make up to 100%.
Comparative example 2A sunscreen composition
The sunscreen composition was similar to example 2;
the difference from example 2 is that no collagen was added in comparative example 2, and the addition amount of photo-lyase was 2%.
Comparative example 3A sunscreen composition
The sunscreen composition was similar to example 2;
the difference from example 2 is that no photo-lyase was added in comparative example 3 and the amount of collagen added was 2%.
Comparative example 4A sunscreen composition
The sunscreen composition was similar to example 1;
The difference from example 1 is that the sunscreen of comparative example 4, the removal of phenylbenzimidazole sulfonic acid, ethylhexyl triazone, and the addition of 6% terephthalamide sulfonic acid, 6% ethylhexyl methoxycinnamate, in comparative example 4.
Comparative example 5A sunscreen composition
The sunscreen composition was similar to example 1;
The difference from example 1 is that the sunscreen of comparative example 5 removes phenylbenzimidazole sulfonic acid, bis-ethylhexyloxyphenol methoxyphenyl triazine, increasing 6% of terephthalene dicamphsylic acid, 7% of ethylhexyl methoxycinnamate.
Comparative example 6A sunscreen composition
The sunscreen composition was similar to example 1;
the difference from example 1 is that the sunscreen of comparative example 6 was free of methylenebis-benzotriazole tetramethylbutylphenol, bis-ethylhexyloxyphenol methoxyphenyl triazine, titanium dioxide, and increased by 1% for terephthalylenedicamphsylic acid and 8% for ethylhexyl methoxycinnamate.
Test example 1 safety test
1. Test sample: sunscreen compositions prepared in groups 1-6 and comparative examples 1-6.
2. Test object: 360 volunteers are selected, each half of men and women are aged 20-45 years, the body is healthy, and the average is divided into 12 groups of 30 people.
3. The test process comprises the following steps: patch tests were performed on the sunscreen compositions prepared in examples 1-6 and comparative examples 1-6. The patch tester is selected, about 0.020-0.025 mL of each test sample is placed in the patch tester by a closed patch test method, the test sample is applied to the back of a subject by a medical adhesive tape, the test sample is removed after 24 hours, skin reactions of 0.5 hours, 24 hours and 48 hours after the patch is removed are observed, and the result is recorded according to the skin reaction grading standard in cosmetic safety technical Specification (2015).
The skin adverse reaction grading criteria are shown in Table 2 below.
TABLE 2 skin adverse reaction grading criteria
4. Test results: the human skin closed patch test shows that 0 cases of 30 persons in each group have positive reaction, and the products of examples 1-6 and comparative examples 1-6 do not cause adverse skin reaction to the subjects in the group according to the specification of cosmetic safety technical Specification (2015).
Test example 2 relaxation test
1. Test sample: sunscreen compositions prepared in examples 1-6.
2. Screening test objects: in the nasolabial folds, 50. Mu.L of a 10% lactic acid solution was dropped on a single layer of filter paper having a diameter of 8mm, and the subjects were asked to score at 2.5min and 5min, respectively, and were scored according to a 4-level method (0 for no tingling, 1 for mild tingling, 2 for moderate tingling, and 3 for heavy tingling). The accumulation of the stinging sensation of 2.5min and 5min is more than or equal to 3, and the stinging sensation of lactic acid is positive. 180 lactic acid stabbing positive volunteers were selected, aged 20-45 years, and randomized into 6 groups of 30 persons each.
3. The test process comprises the following steps: the tested parts of the tested volunteers cannot be used for external cosmetics, external medicines and internal health care products 15 days before testing.
Test part: the test was performed on the nasolabial folds of the subjects, and after feeling stinging, 50. Mu.L of 10% lactic acid solution was applied to each of the two nasolabial folds, and the sunscreen compositions of examples 1 to 6 were applied to each of the two nasolabial folds at the level of 50. Mu.L. After the application, cumulative scores of the stinging sensation were recorded for 2.5 minutes and 5 minutes on the two sides of the nasolabial folds, respectively. The average of the cumulative scores of the stinging sensations was calculated for each group for 2.5 minutes and 5 minutes.
The cumulative average score of tingling = (total score of 2.5min + total score of 5 min)/30.
4. Test results: the specific test results are shown in Table 3.
TABLE 3 lactic acid stinging test results
As is evident from Table 3 above, the pain sensation is significantly reduced after 5 minutes in the volunteers using the sunscreen compositions of the present invention of groups 1-6, demonstrating the soothing effect of the present invention.
Test example 3 Sun protection index test
1. Test sample: the sunscreen compositions prepared in examples 1-6 and comparative examples 1-3;
2. Test object: 45 men and women volunteers each, the ages of which are 20-37, meet the volunteer selection standard of the subjects, and are equally divided into 9 groups of 10 persons each.
3. The test process comprises the following steps: light source: xenon arc lamp sunlight simulator. Test part: back part
Control: SPF value 16.1+ -2.4, according to the standard formulation of the medium and high SPF standard (P2) of cosmetic safety technical Specification (2015 edition).
The testing method comprises the following steps: the test was carried out according to the specific requirements of cosmetic safety Specification (2015 edition). The subject takes the prone position and irradiates his back. The minimum erythema dose (MED value) of the subject's skin to ultraviolet irradiation was predicted 24 hours before the test, and the ultraviolet irradiation dose was adjusted based on the prediction result, for testing the test object. Firstly, selecting a normal skin area which is not smaller than 30cm on the back of a test subject on the test day, uniformly smearing an object to be tested or a reference substance in the area according to the dosage of (2.00+/-0.05) mg/cm, then selecting the irradiation dosage according to the standard requirement, and carrying out irradiation under three conditions: ① The skin of the subject is not coated with the test object; ② Coating a reference substance; ③ Coating the measured object. After 24 hours, the experimental results were observed and MED values were recorded for the three cases, respectively. The SPF value calculating method comprises the following steps: the SPF value of the test object or the reference object for protecting the single subject is expressed by the following formula:
The SPF value of the individual is required to be accurate to one digit after the decimal point, the arithmetic average of the SPF values of all the tested objects protected by the tested objects is calculated, and the integer part of the arithmetic average is taken as the SPF value of the tested sample. The sampling error of the estimated mean may calculate the standard deviation and standard error for the set of data. The 95% confidence interval (95% ci) of the mean is required to be no more than 17% of the mean, otherwise the number of subjects should be increased (no more than 25) until the above requirement is met.
4. Test results: the specific test results are shown in Table 4.
TABLE 4 Sun Protection Factor (SPF) test results for different test samples
As is clear from Table 1, the sunscreen compositions and the amounts added in examples 1 and 2 were the same, but the proportions of collagen and photo-lyase were different. The sunscreen components and amounts added in examples 3 and 4 were the same, except that the proportions of collagen and photo-lyase were different. The sunscreen components and amounts added in examples 5 and 6 were the same, except that the proportions of collagen and photo-lyase were different.
As can be seen from the above table, sun protection factor example 2> example 1, sun protection factor example 4> example 3 sun protection factor example 6< example 5. It was demonstrated that when 4 mass% of photo-lyase and 4 mass% of collagen were added, the sun protection effect was best, the Sun Protection Factor (SPF) was 55, and the use of these 2 components in example 6 was higher than example 5, but the sun protection effect was reduced, and it was demonstrated that the higher the use of these two components was not the better.
Furthermore, sun Protection Factor (SPF) example 2> comparative example 1, comparative example 2, comparative example 3. Comparative example 2 increased the SPF by 2 compared to comparative example 1, comparative example 3 increased the SPF by 1 compared to comparative example 1, example 2 increased the SPF by 9,9>2+1 compared to comparative example 1, demonstrating that the combination of photo-lyase and collagen in example 2 synergistically enhanced the sun protection factor, effectively improving the sun protection effect of the composition.
Test example 4 skin feel contrast test
1. Test sample: the sunscreen compositions prepared in example 1 and comparative examples 4-6;
2. test object: 80 volunteers are selected, and the ages of the volunteers are in the range of 20-45 years, and are equally divided into 4 groups of 20 people each.
3. The test method comprises the following steps: trial part: a face. The testing method comprises the following steps: the sun-proof composition is coated on the face, the coating is uniform, the coating feel and the greasy feel in the coating process are sensed, the coating is difficult to be coated (0 part) -easy to be coated (10 parts) (0-10 parts), the sun-proof composition is very non-greasy (0 part) -greasy (10 parts) (0-10 parts), the scoring is carried out, and then the average value of the coating feel and the greasy feel of a user is taken.
4. Test results: the specific test results are shown in Table 5.
TABLE 5 skin feel test results for different test samples
From this, it can be seen that the example 1 of the present invention has better spreadability and greasy feel than the sunscreen skin care products prepared in comparative examples 4 to 6, which means that the combination of sunscreens selected in the present invention can meet the requirements of good spreadability and non-greasy feel.
Finally, it should be noted that the above-mentioned embodiments are merely illustrative of the principles, performances and effects of the present invention, and are not meant to limit the invention. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications and variations of the invention be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.
Claims (7)
1. A sunscreen composition comprising a photo-lyase and collagen, characterized by comprising the following components in percentage by mass: 1-5% of photo-lyase, 1-5% of collagen, 10-40% of sun-screening agent, 20.91-53.6% of auxiliary material and the balance of deionized water; the sun-screening agent comprises a water-soluble sun-screening agent and an oil-soluble sun-screening agent, wherein the water-soluble sun-screening agent comprises phenylbenzimidazole sulfonic acid and methylene bis-benzotriazole tetramethylbutylphenol; the oil-soluble sunscreen agent comprises ethylhexyl triazone, bis-ethylhexyl oxyphenol methoxyphenyl triazine and titanium dioxide; the sun-screening agent is prepared from phenylbenzimidazole sulfonic acid, ethylhexyl triazone, bis-ethylhexyl oxyphenol methoxyphenyl triazine, methylene bis-benzotriazole tetramethylbutylphenol and titanium dioxide according to the mass ratio of 3-8:3-8:3-8:1-8:1-5 parts; the collagen is prepared from type I collagen, type III collagen and other collagen according to the mass ratio of 12-15: 1-5: 87-80 parts; the other collagen is type II collagen.
2. A sunscreen composition according to claim 1, comprising the following components in percentage by mass: 4% of photo-lyase, 4% of collagen, 33% of sun-screening agent, 40.1% of auxiliary material and the balance of deionized water.
3. A sunscreen composition according to claim 1, wherein said auxiliary material comprises the following components and their respective mass percentages in said sunscreen composition: 1-3% of humectant, 0.01-0.1% of chelating agent, 10-20% of emollient, 0.1-1% of skin conditioner, 0.5-1% of preservative, 5-15% of emulsifier, 5-12% of thickener and 0.3-1.5% of pH regulator.
4. A sunscreen composition according to claim 3, wherein the emulsifier comprises a water-soluble emulsifier and an oil-soluble emulsifier, wherein the water-soluble emulsifier is one or more of disodium cetostearyl alcohol sulfosuccinate, disodium cetylstearyl alcohol sulfosuccinate, and the oil-soluble emulsifier is one or more of steareth-2, steareth-21, arachidyl glucoside, PEG-100 stearate, glycerol stearate, cetylstearyl glucoside, sodium stearyl glutamate, disodium cetylstearyl alcohol sulfosuccinate, cetyl PEG/PPG-10/1 polydimethylsiloxane, PEG-10 polydimethylsiloxane, PEG-9 polydimethylsiloxane ethyl polydimethylsiloxane, sorbitan oleate, sorbitan stearate; the thickener comprises a water-soluble thickener and an oil-soluble thickener, wherein the water-soluble thickener is one or more of xanthan gum, carbomer, hydroxyethyl cellulose and acrylic acid (esters) of C10-30 alkanol acrylate crosslinked polymers; the oil-soluble thickener is one or more of paraffin, beeswax, carnauba wax, bentonite and disteardimonium hectorite.
5. The sunscreen composition of claim 4, wherein the humectant is one or more of glycerin, propylene glycol, butylene glycol, pentylene glycol, glyceryl polyether-26, saccharide isomers, hexylene glycol, octylene glycol, betaine, allantoin, trehalose; the chelating agent is one of disodium EDTA and tetrasodium EDTA; the emollient is one or more of diisopropyl sebacate, squalane, caprylic/capric triglyceride, ceramide NP, phosphatidylcholine, butter tree fruit fat, isohexadecane, silicone oil, olive oil, ethylhexyl palmitate and jojoba ester oil; the preservative is one or more of methylparaben, propylparaben, phenoxyethanol, anisic acid, dehydroacetic acid, benzyl alcohol and iodopropynyl butyl carbamate; the pH regulator is one or more of arginine, citric acid, sodium citrate, sodium hydroxide and potassium hydroxide; the skin conditioner is one or more of herba Centellae extract, madecassoside, radix Cynanchi Atrati extract, mandarin orange pericarp extract, carnosine, glutathione, kava root extract, gluconolactone, salicylic acid, azelaic acid, and p-hydroxyacetophenone.
6. A method of preparing a sunscreen composition according to any one of claims 4 to 5, comprising the steps of:
S1, adding deionized water, a humectant, a chelating agent, a skin conditioning agent, a water-soluble emulsifying agent, a water-soluble thickening agent and 1/2 water-soluble sun-screening agent into a water phase pot, starting stirring, heating to 80-85 ℃, and uniformly dispersing to obtain a phase A;
S2, adding an emollient, an oil-soluble emulsifier, an oil-soluble thickener and an oil-soluble sun-screening agent into an oil phase pot, heating to 80-85 ℃, and uniformly stirring and dispersing to obtain a phase B;
s3, pumping the phase A in the step S1 and the phase B in the step S2 into an emulsifying pot, homogenizing at a high speed, stirring uniformly, and cooling to 60-65 ℃ to obtain a mixture I;
s4, adding a preservative and a pH regulator into the mixture I prepared in the step S3, uniformly stirring, and homogenizing for 3-8min; stirring and cooling to 40-45 ℃ to obtain a mixture II;
And S5, adding the rest water-soluble sun-screening agent, collagen and photo-lyase into the mixture II prepared in the step S4, uniformly stirring, detecting to be qualified, and discharging to obtain the product.
7. Use of a sunscreen composition according to claim 1 in the preparation of a skin care product.
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