CN1180787C - Improved process for preparing medicinal assistant - Google Patents
Improved process for preparing medicinal assistant Download PDFInfo
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- CN1180787C CN1180787C CNB001039520A CN00103952A CN1180787C CN 1180787 C CN1180787 C CN 1180787C CN B001039520 A CNB001039520 A CN B001039520A CN 00103952 A CN00103952 A CN 00103952A CN 1180787 C CN1180787 C CN 1180787C
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- extracting solution
- adrenal cortex
- anterior pituitary
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- material powder
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Abstract
The present invention relates to a production method for rheumatoid disease resisting medicine, particularly to an improvement of a production method for preparing a medicinal assistant. Because the method changes an acetone precipitation method into a drying method at constant temperature of 60 DEG C, the extraction rate of the effective components of the medicine is increased by more than 50%. Because the method changes the existing hydrochloric acid and acetone extraction method into a single hydrochloric acid (pH 3.5) extraction method and prolongs the extraction holding time from original 20 minutes to 120 minutes, the effective components of the adrenal gland and the hypophysis reach optimal saturation with hydrochloric acid whose pH value is 3.5. Thus, a lot of acetone is saved, and the manufacturing cost is decreased greatly. The method has the advantages of high effective components, obvious therapeutic effect, simple process step, low cost, etc.
Description
Technical field: the present invention relates to the production method of resisting rheumatoid disease medicament, particularly relate to a kind of improvement of process for preparing medicinal assistant.
Background technology: rheumatoid is common, multiple, the difficult disease of world wide, does not have the specific treatment method for a long time.The inventor has proposed " stress bad theory " in the seventies by etiological analysis, uses the assistant medicine on this basis, makes rheumatoid treatment that tangible breakthrough arranged.And should " production method of medicinal " zhuyingsu " " to Patent Office of the People's Republic of China application for a patent for invention have been proposed on November 1st, 85, its application number is 85108078.The invention of this method is to be raw material with animal adrenal gland and hypophysis cerebri, is that principal agent synthesizes medicinal " zhuyingsu " with intermediate adrenal cortex extract and intermediate anterior pituitary extract.The production method of its intermediate adrenal cortex extract is identical substantially with the production method of intermediate anterior pituitary extract, promptly earlier with the treated raw material powder that makes of raw material, again through extracting, precipitate, make xeraphium, dissolve with double distilled water at last, glucosan G100 column chromatography, solution makes the intermediate extract with acetone solvent precipitation, filtration, drying.Because this kind preparation is animal brain antepituitary and adrenal cortex extract, its effective ingredient can be fully saturated with sour lyase.And present acetone extraction is to have taked ACTH precipitation extraction method, find through practical proof, still have the abandoned of mass efficient composition in the filtrate of its post precipitation, this has not only had a strong impact on the utilization rate of active ingredient, and the curative effect of this preparation has also been produced obvious influence.Utilizing in the middle of the acetone extraction method, must add the acetone precipitation 24 hours of huge amount, not only expending a large amount of acetone, its actual effect is also desirable not to the utmost, and makes the manufacturing cost of medicament high for a long time.
Summary of the invention: the objective of the invention is and to improve existing process for preparing medicinal assistant,, simplify production routine, and reduce production costs in the hope of when increasing curative effect.
The improvement of assistant production method involved in the present invention mainly comprises the making raw material powder, extracts production procedures such as medicament dry powder, and its method of extracting medicament dry powder is:
A, adrenal cortex raw material powder and anterior pituitary raw material powder put into respectively extract pot, add mineral acid and fully stir,, make adrenal cortex extracting solution and anterior pituitary extracting solution respectively through water-cooled, ultrafiltration; B, in above-mentioned two kinds of extracting solution, slowly splash into the sodium chloride solution that concentration is 5M respectively, abandon supernatant and must mix heavy earnest through leaving standstill, inhaling; C. above-mentioned mixed sediment is put into vacuum desiccator respectively, adopt 60 ℃ of freeze-day with constant temperature method oven dry, can obtain adrenal cortex medicament dry powder and anterior pituitary medicament dry powder respectively.
The above-mentioned adrenal cortex extracting solution and the preparation method of anterior pituitary extracting solution are:
A, adrenal cortex raw material powder and anterior pituitary raw material powder put into respectively extract pot, add the hydrochloric acid of pH3.5, fully stir; B, in water-bath, be heated to 50 ℃, kept 120 minutes; C. sucking filtration after the water-cooled to 30 ℃ can obtain adrenal cortex extracting solution and anterior pituitary extracting solution respectively.
The present invention is owing to change acetone precipitation into 60 ℃ of freeze-day with constant temperature oven drying methods, thereby makes this medicament active ingredient extraction ratio increase more than 50%; Change existing hydrochloric acid acetone extraction method into single hydrochloric acid extraction method, and be extended for 120 minutes by the original 20 minutes extraction retention time, make the hydrochloric acid of adrenal gland and hypophysis cerebri active ingredient and pH3.5 reach best saturated, thereby saved a large amount of acetone, greatly reduce manufacturing cost.Have the active ingredient height, evident in efficacy, advantage such as processing step is simple, and is with low cost.
The specific embodiment:
Production method below in conjunction with medicinal " zhuyingsu " provides preferred forms of the present invention:
The present invention is to be principal agent with intermediate adrenal cortex extract, intermediate anterior pituitary extract, the medicinal " zhuyingsu " injection formulated with an amount of antibacterial.The required raw materials for production of its intermediate adrenal cortex extract and intermediate anterior pituitary extract are respectively fresh complete animal adrenal gland and animal brain hypophysis.Concrete production method is as follows:
1, raw material is handled: adrenal gland is put into organic solvent (acetone) dehydration three times, the adrenal gland of dehydration is separated the marrow layer, peel off fully, the cortical layer that separates is put into organic solvent to be stored standby, hypophysis cerebri is put into organic solvent (acetone) dehydration three times, the forward and backward leaf strip off of the hypophysis cerebri of dehydration is separated, get frontal lobe and put into organic solvent, sealing is stored standby.
2, manufacture raw material powder: adrenal cortex layer and the anterior pituitary that will handle take out from organic solvent separately respectively, put after the ventilating and cooling place distributes organic solvent, with its pulverize separately, cross 60 mesh sieves, drying under reduced pressure, treat that moisture content reduces to 6% when following, adrenal cortex and anterior pituitary raw material powder are promptly made in the bottling sealing respectively;
3, extract medicament dry powder: get each 1000 gram of adrenal cortex raw material powder and anterior pituitary raw material powder, put into respectively and extract pot, add the hydrochloric acid of an amount of (being generally about 5000 milliliters) pH3.5, fully stir, in water-bath, be heated to 50 ℃, kept 120 minutes.Sucking filtration after the water-cooled to 30 ℃, filtrate is put in the freezer and is spent the night, and ultrafiltration is till the filtrate clarification.Promptly make adrenal cortex extracting solution and anterior pituitary extracting solution respectively.Adding concentration in per 1000 milliliters of extracting solution is 10 milliliters of 5M sodium chloride solutions, slowly splash into and Jiao Ban Zhuo even, leave standstill, inhale and abandon supernatant and get mixed sediment.Above-mentioned mixed sediment is put into vacuum desiccator respectively, use the phosphorus pentoxide drying, adopt 60 ℃ of freeze-day with constant temperature method oven dry.Can obtain adrenal cortex and anterior pituitary medicament dry powder respectively.Be placed in the vacuum desiccator standby respectively.
4, preparating liquid: get adrenal cortex and anterior pituitary medicament dry powder,, be mixed with 2 milliliters of liquid embeddings, be medicinal " zhuyingsu " injection finished product through after the medicine inspection with sterile distilled water respectively by 12.5 milligrams and add 0.3% chlorobutanol.
Claims (2)
1, a kind of improvement of process for preparing medicinal assistant comprises and makes raw material powder, extraction medicament dry powder main production process, it is characterized in that the method for described extraction medicament dry powder is:
A, adrenal cortex raw material powder and anterior pituitary raw material powder put into respectively extract pot, the hydrochloric acid solution that adds pH3.5 fully stirs, and through water-cooled, ultrafiltration, makes adrenal cortex extracting solution and anterior pituitary extracting solution respectively;
B, in above-mentioned two kinds of extracting solution, slowly splash into the sodium chloride solution that concentration is 5M respectively, abandon supernatant and get mixed sediment through leaving standstill, inhaling;
C, above-mentioned mixed sediment is put into vacuum desiccator respectively, adopt 60 ℃ of freeze-day with constant temperature methods oven dry, can obtain adrenal cortex and anterior pituitary medicament dry powder respectively.
2, the improvement of a kind of process for preparing medicinal assistant according to claim 1 is characterized in that the preparation method of described adrenal cortex extracting solution and anterior pituitary extracting solution is:
A, adrenal cortex raw material powder and anterior pituitary raw material powder put into respectively extract pot, add the hydrochloric acid of pH3.5, fully stir;
B, in water-bath, be heated to 50 ℃, kept 120 minutes;
Sucking filtration after c, water-cooled to 30 ℃ leaves standstill;
Can obtain adrenal cortex extracting solution and anterior pituitary extracting solution respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001039520A CN1180787C (en) | 2000-03-13 | 2000-03-13 | Improved process for preparing medicinal assistant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001039520A CN1180787C (en) | 2000-03-13 | 2000-03-13 | Improved process for preparing medicinal assistant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1313092A CN1313092A (en) | 2001-09-19 |
| CN1180787C true CN1180787C (en) | 2004-12-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001039520A Expired - Fee Related CN1180787C (en) | 2000-03-13 | 2000-03-13 | Improved process for preparing medicinal assistant |
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| Country | Link |
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| CN (1) | CN1180787C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103694341A (en) * | 2013-11-23 | 2014-04-02 | 青岛康原药业有限公司 | Preparation method of corticotropin |
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2000
- 2000-03-13 CN CNB001039520A patent/CN1180787C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1313092A (en) | 2001-09-19 |
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