CN118047161A - Multichannel friction access system for biological medicine samples - Google Patents

Abstract

A multichannel friction access system for biological medicine samples comprises a sample bottle friction access mechanism, a sample bottle storage unit, an automatic sealing mechanism, a gas transmission mechanism and a transition transfer mechanism which are sequentially arranged from top to bottom, wherein the sample bottle friction access mechanism, the sample bottle storage unit, the automatic sealing mechanism and the gas transmission mechanism are sequentially arranged from top to bottom; the sample bottle friction access mechanism comprises a bracket, a sample bottle access unit and a sample bottle access driving mechanism, wherein the sample bottle access driving mechanism drives a sample bottle transfer channel or a sample bottle warehouse-in channel in the sample bottle access unit to be in butt joint with the sample bottle storage unit, or drives a sample bottle warehouse-out channel to be in butt joint with the transition transfer mechanism. Each part forms a closed sample bottle storage and access system in the temperature control box. The sample bottle containing the sample is stored in the sample bottle storage unit. The system realizes the sealed efficient storage and the storage of samples in an ultralow temperature environment and the rapid batch taking out.

Description

Multichannel friction access system for biological medicine samples

Technical Field

The invention relates to a device for storing samples in the field of biological medicine, and belongs to the technical field of sample storage.

Background

Drug screening is typically accomplished independently by researchers, each with a large number of compounds, and also requires exchange of compounds or information with other researchers. In drug screening processes, thousands of precious compounds or biological samples need to be stored and managed. Sample safety, sample tracking, data tracing, and ensuring that accurate samples are taken when needed are important issues of concern to laboratory administrators today.

The quality of the sample is mainly affected by the storage temperature, humidity and time, and especially the quality of the articles with severe storage environment is affected by small storage environment changes. Some samples are not easy to get, and once lost or deteriorated, irreparable losses are caused. Safe storage and management of samples is a major topic that is urgently needed to be addressed, especially the scientific management of samples in the laboratory is of great importance for rapid development and orderly operation of the whole laboratory. At present, the sample information also lacks unified management standards, basically is 'each for administration', which is not matched with high-throughput drug screening, and the research and development efficiency of the drug is seriously braked.

Samples are generally stored in a frozen or refrigerated environment and are taken out of the frozen or refrigerated environment, in either case, the doors of the refrigerated environment (such as a refrigerator or a freezer) are required to be opened, and sometimes the doors are frequently opened, so that convection of the inside air and the outside air is caused, fluctuation and change of the refrigerated environment (such as temperature and humidity) are caused, and the stability of the storage environment is affected.

The quality of the stored samples is mainly affected by the storage temperature, humidity and time, especially for articles with severe storage environment requirements, and the quality is affected by small storage environment changes. Currently, conventional refrigerators or freezers are used for storage. The phenomena of repeated freezing, humidity fluctuation, change and the like exist in the storage process, so that the sample is extremely easy to fail; when in use, the 'turnover and cabinet-falling' search is also needed, and the sample is easy to miss; sample characterization, usage records also lack a unified specification.

The Chinese patent document CN201504517U discloses a tissue sample storage drawer, which comprises at least one drawer frame, wherein at least one drawer is arranged in each drawer frame, handles are arranged on the drawers, and equidistant intervals are arranged in at least one drawer; the other drawers are provided with round hole plates, the lower surfaces of the round hole plates are provided with positioning feet, the positioning feet are embedded into the drawers, and round holes are formed in the round hole plates. The storage drawer can store a certain amount of samples, but the number of stored samples is still limited, and the operation and the search are inconvenient, and automatic access is not easy to realize.

CN102303763a discloses a "honeycomb type composite rotary sample storage device", which comprises a vertical shaft, sample storage disks and a disk driving mechanism, wherein each sample storage disk is installed on the same vertical shaft in parallel up and down, sample nests and sample transmission channels are distributed on the sample storage disks, each sample storage disk is connected with one set of disk driving mechanism, and each set of disk driving mechanism is installed on a bracket fixed at the bottom of the vertical shaft. The sample nest is ring-shaped distribution, and ring quantity is two at least rings, and all rings are concentric, sets up a sample transmission channel at least on every ring. Although the device solves the defect of the existing sample storage, the device can be placed in a closed storage environment, and then the means such as refrigeration technology, pneumatic technology, sensing technology, bar code identification, database management, network communication and the like are used to realize the automatic access and the intelligent data management of the sample. However, there is a problem that the cooperation of the vertical shaft and the sample storage disc cannot adapt to the ultra-low temperature environment, and the disc driving mechanism, particularly the electrical system, is limited in adaptation temperature, and cannot operate in the ultra-low temperature environment.

Disclosure of Invention

Aiming at the defects of the existing sample storage technology, the invention provides a biomedical sample multichannel friction access system which has large capacity and can rapidly access samples in batches in an ultralow temperature environment.

The invention relates to a biomedical sample multichannel friction access system, which adopts the following technical solutions:

The system comprises a sample bottle friction access mechanism, a sample bottle storage unit, an automatic sealing mechanism, a gas transmission mechanism and a transition transfer mechanism which are sequentially arranged from top to bottom, wherein the sample bottle friction access mechanism, the sample bottle storage unit, the automatic sealing mechanism and the gas transmission mechanism are sequentially arranged from top to bottom;

The sample bottle friction access mechanism comprises a bracket, a sample bottle access unit and a sample bottle access driving mechanism, wherein the sample bottle access driving mechanism is arranged on the bracket (the sample bottle access unit performs work under the drive of the access driving mechanism); the sample bottle access unit comprises a sample bottle conveying mechanism and a conveying pipeline, and the conveying pipeline is connected to the sample bottle conveying mechanism; the sample bottle conveying mechanism comprises a support, a sample bottle conveying bin, a conveying belt, belt wheels and a servo motor, wherein two belt wheels are arranged on the support, one belt wheel is connected with the servo motor, and the conveying belt is arranged on the two belt wheels and is embedded in the sample bottle conveying bin; the transport pipeline comprises a sample bottle warehousing channel, a warehousing high-pressure gas pipeline, a sample bottle ex-warehouse channel, an ex-warehouse high-pressure gas pipeline, a sample bottle transfer channel and a transfer high-pressure gas pipeline, and each high-pressure gas pipeline is provided with a control valve; the sample bottle storing and taking driving mechanism is at least provided with one set, and the sample bottle transferring channel or the sample bottle storing channel is driven to be in butt joint with a sample bottle storing unit (particularly a storing pipe in the sample bottle storing unit), or the sample bottle discharging channel is driven to be in butt joint with a transition transferring mechanism (particularly a sample bottle transferring pipe in the transition transferring mechanism).

Further:

The sample bottle transporting bin is provided with three identification devices, wherein two of the identification devices are symmetrically arranged. The three identification devices can capture the information of the bottle cap, the bottle body and the bottle bottom of the sample bottle at the same time, so that the information of the sample bottle can be read accurately.

The sample bottle warehouse-in channel and the warehouse-in high-pressure gas pipeline are symmetrically arranged on the sample bottle transfer warehouse; the sample bottle delivery channel and the delivery high-pressure gas pipeline are symmetrically arranged on the sample bottle transfer bin.

The sample bottle access driving mechanism comprises a main driving mechanism and an auxiliary driving mechanism, and the auxiliary driving mechanism is connected to the power output end of the main driving mechanism; the main driving mechanism adopts a screw-nut pair moving mechanism; the auxiliary driving mechanism adopts an electric telescopic gripper, and comprises an electric telescopic frame and a gripper, wherein the electric telescopic frame is connected to the power output end of the main driving mechanism, and the gripper is connected to the tail end of the electric telescopic frame.

The sample bottle storage unit adopts a bundling pipe structure and comprises a sealing box, a refrigerating medium exchange port is formed in the side wall of the sealing box, storage pipes are vertically distributed in the sealing box and are fixed through pipe plates at the upper end and the lower end of the sealing box, and the upper end and the lower end of each storage pipe are all open.

The automatic sealing mechanism comprises a heat insulation frame, and an upper partition plate, a middle partition plate and a lower partition plate which are connected together from top to bottom in the heat insulation frame; the upper partition plate is provided with upper through holes, and ventilation grooves are carved on the inner walls of the upper through holes; round through holes are distributed on the middle partition plate, sealing balls are arranged in the round through holes, and the diameter of the round through holes is larger than that of the sealing balls; the lower partition plate is provided with lower through holes; the diameter of the sealing ball is smaller than the inner diameter of the round through hole and larger than the inner diameters of the upper through hole and the lower through hole, and the distribution mode of the upper through hole, the round through hole and the lower through hole is consistent with the distribution mode of the storage pipes in the sample bottle storage unit. An arc spherical surface can be arranged at the upper port of the lower through hole, and the diameter of the arc spherical surface is not larger than that of the sealing ball.

The gas transmission mechanism comprises a frame, a gas transmission nozzle, a gas storage bin, a gas transmission channel and a transmission device, wherein the transmission device is arranged on the frame, the gas storage bin is connected to the transmission device, the gas transmission nozzle is connected with the gas storage bin through a control valve, and the gas transmission channel is connected with the gas storage bin. The gas is conveyed into the gas storage bin through the gas conveying channel, and the transmission device drives the gas storage bin to move, so that the gas conveying nozzle is in butt joint with the sealing mechanism (particularly the lower through hole on the lower partition plate).

The transition transfer mechanism comprises a sample bottle transfer pipe, a sample bottle inlet and outlet, a transition transfer bin and a gas pipe, wherein the sample bottle transfer pipe is connected above the transition transfer bin; the transition transfer bin is internally provided with a three-dimensional moving platform, a transition bin, a sample bottle tray and a transfer bracket, and the transfer bracket is arranged at the power output end of the three-dimensional moving platform; the transition bin comprises a bin frame and a supporting plate, the supporting plate is fixed in the bin frame, and a sample bottle tray is arranged on the supporting plate; the gas pipe is arranged on the side wall of the transition bin, one end in the transition bin is opposite to the port of the sample bottle transfer pipe, and the other end of the gas pipe is connected with a gas transmission mechanism (in particular to a gas transmission nozzle in the gas transmission mechanism). The sample bottle tray is characterized in that a sample bottle placing hole is formed in the sample bottle tray body, and a carrying notch is formed in the bottom of the sample bottle tray body. The sample bottle placing hole is a stepped through hole, the diameter of the upper part is large, and the diameter of the lower part is small; the upper portion of sample bottle placing hole is placed to the sample bottle, and the lower part of sample bottle placing hole is used for getting into gas, blows out the sample bottle. The transfer bracket is provided with a carrying claw, an air guide hole (when the sample bottle tray is arranged on the transfer bracket, the air guide hole corresponds to the sample bottle placing hole above the air guide hole), the carrying claw is inserted into a carrying notch when the sample bottle tray is transferred, and air enters the sample bottle placing hole through a through hole on the carrying claw to blow out the sample bottle.

The whole system is arranged in an environment required by sample storage to form a closed sample bottle storage and access system, a sample bottle for containing a sample is stored in a sample bottle storage unit, and the processes of storing, taking and storing the sample bottle are completed under the combined action of a sample bottle friction access mechanism, an automatic sealing mechanism, a gas transmission mechanism and a transition transfer mechanism.

The invention has the following characteristics:

1. In the sample bottle access unit, a conveying belt is arranged and is inlaid in a sample bottle conveying bin slot to form a closed cavity with a sample conveying bin, the conveying belt has a certain roughness, and the sample bottle sequentially moves along with the conveying belt under the action of friction force.

2. In the sample bottle access unit, a plurality of sample bottle transfer channels are arranged, so that a plurality of sample bottles can enter the sample transfer bin simultaneously, and the access speed is improved.

3. The sample transfer bin is provided with a lateral high-pressure gas inlet (relative to the warehousing direction), lateral thrust is given to the warehousing sample bottles, so that the sample bottles can be quickly opened to leave open the passage opening for warehousing of the subsequent sample bottles, and meanwhile, the auxiliary lateral thrust function is also achieved, the sample bottle inclination phenomenon is corrected, and the blockage caused by the inclination of individual sample bottles is prevented.

4. A pair of identification devices are symmetrically arranged, so that information of a sample bottle cap and a bottle bottom can be simultaneously paved and grasped, or the phenomenon that the sample bottle is missed due to inconsistent orientation of a sample bottle warehouse-in bottle cap when only the bottle cap has the sample bottle information is prevented.

5. The third identification device is arranged, the information of the bottle body of the sample bottle is paved and grasped, the accuracy of the information of the sample bottle is ensured through the comparison of the bottle cap and the information of the bottle body, and meanwhile, the sample bottle with abnormal information is taken out, so that the information of the sample bottle stored in the storage unit is ensured to be accurate.

6. The multiple sets of sample bottle access driving mechanisms are arranged, and the auxiliary driving mechanism is arranged on the main driving mechanism, so that multiple target tasks can be executed simultaneously, the efficiency of the system is improved, and the flexible function of the system is enhanced.

7. The storage pipe is arranged in the sealing box, so that the sample bottle can independently share the temperature and humidity storage environment, the environmental requirement of sample storage is met, and meanwhile, a lower storage temperature environment can be built, and the requirement of a specific sample storage environment is met.

8. The storage pipe is arranged in the sealing box, can prevent the temperature from overflowing, is convenient for building a storage environment lower than minus 25 ℃, can use conventional materials, devices, parts and mechanisms, reduces the equipment cost and improves the safety and the reliability. The use environment temperature of the conventional actuating mechanism is higher than minus 25 DEG (25 ℃ below zero).

9. The automatic sealing mechanism relies on the self mass of the sealing ball and the principle of universal gravitation, the self-efficient sealing is realized, and the stability and the reliability of the system are improved.

10. The transition transfer mechanism is provided with a plurality of supporting plates, and a three-dimensional moving platform is arranged, so that the sample bottle tray can move in the X-axis, Y-axis and Z-axis directions.

11. Sample bottle placing holes are formed in the sample bottle tray, the sample bottle placing holes are stepped through holes, and storage of sample bottles is achieved through pneumatic conveying.

12. The bottom of sample bottle tray body is provided with the transport notch, is provided with the transport claw on the transfer bracket, and the transport claw inserts the transport notch when transporting sample bottle tray, has realized sample bottle safe and reliable's transfer.

Drawings

FIG. 1 is a schematic diagram of the whole structure of a biomedical sample multi-channel friction access system according to the present invention.

FIG. 2 is a schematic view of a sample bottle friction access mechanism according to the present invention.

Fig. 3 is a schematic view of the structure of the sample bottle access unit in the sample bottle friction access mechanism.

Fig. 4 is a schematic structural view of a sample bottle transporting mechanism in the sample bottle access unit.

Fig. 5 is a schematic view of the structure of the sample bottle transfer bin in the sample bottle transport mechanism.

Fig. 6 is a schematic structural view of a transport pipe in the sample bottle access unit.

Fig. 7 is a schematic diagram of a sample bottle warehouse-in channel structure in a transport pipeline.

Fig. 8 is a schematic diagram of a sample bottle transfer channel structure in a transport conduit.

Fig. 9 is a schematic view of the structure of the high pressure gas channel in the transport pipe.

Fig. 10 is a schematic view of the arrangement of the drive mechanism in the sample bottle friction access mechanism.

Fig. 11 is a schematic structural view of the sub-driving mechanism in the driving mechanism.

Fig. 12 is a schematic structural view of a sample bottle storage unit in the present invention.

Fig. 13 is a schematic view showing a state in which a sample bottle is in a storage tube in the sample bottle storage unit.

Fig. 14 is a schematic view of the structure of the automatic sealing mechanism in the present invention.

Fig. 15 is a schematic view of the structure of the upper partition in the automatic sealing mechanism.

Fig. 16 is a schematic view of the structure of the intermediate plate of the automatic sealing mechanism.

Fig. 17 is a schematic view of the structure of the lower partition in the automatic sealing mechanism.

Fig. 18 is a schematic view of the structure of the air delivery mechanism in the present invention.

FIG. 19 is a schematic view of the structure of the gas storage bin in the gas delivery mechanism.

FIG. 20 is a schematic view of a transition transfer mechanism according to the present invention.

FIG. 21 is a schematic view of the structure of a sample bottle transfer tube in a transition transfer mechanism.

Fig. 22 is a schematic structural view of a transition shift cartridge in the transition shift mechanism.

FIG. 23 is a schematic structural view of a transition cartridge in the transition transfer mechanism.

Fig. 24 is a schematic view of the structure of a sample bottle tray in a transition transfer bin.

Fig. 25 is a schematic view of the structure of a transfer carriage in a transition transfer bin.

FIG. 26 is a schematic view of the structure of the gas delivery tube in the transition shift bin.

Wherein: 1. the temperature and humidity control box, the sample bottle friction access mechanism, the refrigeration control unit, the sample bottle storage unit, the automatic sealing mechanism, the gas transmission mechanism and the transition transfer mechanism are respectively arranged in the temperature and humidity control box, the sample bottle friction access mechanism, the refrigeration control unit, the sample bottle storage unit, the automatic sealing mechanism, the gas transmission mechanism and the transition transfer mechanism;

21. A support frame 22, a sample bottle access unit 23, a sample bottle access driving mechanism;

221. transport pipe 222. Sample bottle transport mechanism;

2211. sample bottle transfer bin 2212, support 2213, conveying belt 2214, belt wheel 2215, servo motor;

22111. Warehouse entry channel installation port 22112, high-pressure gas pipeline installation port 22113, identification device installation port 22114, sample bottle transfer channel installation port 22115, high-pressure gas pipeline installation port 22116, sample bottle transfer bin notch 22117, identification device installation port 22118, warehouse exit channel installation port 22119, high-pressure gas pipeline installation port;

2221. Sample bottle warehouse entry channel 2222. Warehouse entry high pressure gas pipeline, 2223. Sample bottle warehouse exit channel, 2224. Warehouse exit high pressure gas pipeline, 2225. Identification device, 2226. Identification device, 2227. Sample bottle transfer channel, 2228. Transfer high pressure gas pipeline;

22211. an interface 22212. A conduit 22213. A capture port;

22271. An interface 22272, a pipeline 22273, a catching opening;

22221. interface 22222. Conduit, 22223. Gas inlet;

231. the warehouse-in driving mechanism, 232, the warehouse-out driving mechanism, 233, the third driving mechanism, 234 and the fourth driving mechanism;

2311. A main driving mechanism; 2312. the auxiliary driving mechanism 2313, the telescopic frame 2314 and the gripper;

41. sealing box, 42, storage tube, 43, sample bottle, 411, refrigerating medium exchange port;

51. the heat insulation frame, 52, an upper partition plate, 53, a sealing ball, 54, a middle partition plate and 55, a lower partition plate;

521. Upper separation through holes 522, ventilation grooves 541, middle separation channel 551, lower separation channel holes 552 and arc spherical surfaces;

61. The device comprises a frame, a gas transmission nozzle, a control valve, a gas storage bin, a gas transmission channel and a transmission device, wherein the frame is provided with the gas transmission nozzle, the control valve, the gas storage bin and the gas transmission channel;

641. The gas storage bin body 642, the valve interface 643, the air supply interface;

71. sample bottle transfer tube 72, transition transfer bin 73, rear cover plate 74, front cover plate 75, sample bottle inlet and outlet;

711. an interface 712, a transfer tube 713, a sample bottle inlet and outlet;

721. Three-dimensional moving platform 722, transition bin 723, sample bottle tray 724, transfer bracket 725, gas pipe;

7221. the bin frame 7222, mounting holes 7223 and supporting plates;

7231. sample bottle tray body 7232 sample bottle placement hole 7233 carrying notch;

7241. Carrying claw 7242, mounting surface 7243, air guide hole 7244 and positioning table;

7251. Air feed port 7252, air delivery pipe body 7253, air delivery interface.

Detailed Description

The biomedical sample multichannel friction access system comprises a sample bottle friction access mechanism 2, a refrigeration control unit 3, a sample bottle storage unit 4, an automatic sealing mechanism 5, a gas transmission mechanism 6 and a transition transfer mechanism 7 which are sequentially arranged from top to bottom as shown in fig. 1. The whole system is arranged in a temperature and humidity control box 1, a refrigeration control unit 3 is arranged in the temperature and humidity control box 1, and the whole system can also be arranged in environments required by storage of other samples. The sample bottle friction access mechanism 2, the sample bottle storage unit 4, the automatic sealing mechanism 5, the gas transmission mechanism 6 and the transition transfer mechanism 7 are sequentially connected from top to bottom, and a closed sample bottle storage and access system is formed in the temperature and humidity control box 1. The sample bottle 43 for containing the sample is stored in the sample bottle storage unit 4, and the processes of storing, taking and storing the sample bottle are completed under the combined action of the sample bottle friction storing and taking mechanism 2, the automatic sealing mechanism 5, the gas conveying mechanism 6 and the transition transferring mechanism 7.

The specific structure of each unit will be described in detail below.

1. Sample bottle friction access mechanism

As shown in fig. 2, the sample vial friction access mechanism 2 includes a holder 21, a sample vial access unit 22, and a sample vial access drive mechanism 23. The sample bottle access drive mechanism 23 is provided on the holder 21, and the sample bottle access unit 22 is provided on the sample bottle access drive mechanism 23.

As shown in fig. 3, the sample bottle access unit 22 includes a sample bottle transporting mechanism 221 and a transporting pipe 222, and the transporting pipe 222 is connected to the sample bottle transporting mechanism 221.

As shown in fig. 4, the sample bottle transporting mechanism 221 includes a support 2212, a sample bottle transporting bin 2211, a transporting belt 2213, pulleys 2214 and a servo motor 2215, two pulleys 2214 are mounted on the support 2212, and one pulley 2214 is connected with the servo motor 2215 and rotates together with the servo motor 2215 to serve as a driving wheel. The transport belt 2213 is mounted on two pulleys 2214 and rotates with the pulleys 2214, and the transport belt 2213 is inlaid in a sample bottle transfer bin slot 22116 in the sample bottle transfer bin 2211. The conveyor 2213 is operated by a servo motor 2215. The sample bottles 43 containing biological samples are placed on the conveying belt 2213 when being put into the warehouse, a lateral high-pressure gas inlet 22115 (relative to the warehouse-in direction) is arranged in the sample bottle transfer warehouse 2211, high-pressure gas provides lateral thrust for the sample bottles 43 entering the sample bottle transfer warehouse 2211 through a transfer high-pressure gas pipeline 2228, the sample bottles 43 leave the inlet (the position of a sample bottle transfer channel mounting opening 22114) rapidly, the opening of the channel is reserved for the subsequent sample bottles 43 entering the sample bottle transfer warehouse 2211, and meanwhile, the auxiliary lateral thrust function is also achieved, the inclination phenomenon of the sample bottles 43 is corrected, and the blockage caused by the inclination of individual sample bottles 43 is prevented.

As shown in fig. 5, the sample bottle transfer bin 2211 is provided with a warehouse entry channel mounting port 22111, a sample bottle transfer channel mounting port 22114, a sample bottle transfer bin slot 22116, a warehouse exit channel mounting port 22118, three high-pressure gas pipe mounting ports, and three identification device mounting ports. The sample bottle transfer bin slot 22116 is used for embedding a conveying belt 2213, the conveying belt 2213 is embedded in the sample bottle transfer bin slot 22116, a closed cavity is formed with the sample transfer bin 2211, and the sample bottle 43 moves along with the conveying belt 2213. The three high-pressure gas pipe installation ports are a high-pressure gas pipe installation port 22112, a high-pressure gas pipe installation port 22119, and a high-pressure gas pipe installation port 22115, respectively. The three recognition device mounting ports are two recognition device mounting ports 22113 and one recognition device mounting port 22117, respectively, which are symmetrical, and the two recognition device mounting ports 22113 mount one recognition device 2226, respectively, and the recognition device mounting port 22117 mounts the recognition device 2225 (see fig. 6). The identification device is an existing two-dimensional code identifier, a radio frequency card identifier and the like, and can accurately identify the two-dimensional code or the radio frequency card and other identifiers on the sample bottle 43. The identification devices 2226 are symmetrically arranged in pairs, so that the information of the bottle caps and the bottle bottoms of the sample bottles 43 can be captured at the same time, or the phenomenon that only the bottle caps have the information of the sample bottles 43 and the directions of the bottle caps of the sample bottles 43 in the warehouse are inconsistent and the information of the sample bottles 43 is missed is prevented. The identification device 2225 is provided for capturing the body information of the sample bottle 43, and ensures the accuracy of the information of the sample bottle 43 by comparing the bottle cap with the body information, and at the same time, the sample bottle 43 with abnormal discrimination information is taken out, further manual discrimination is performed, and the information of the sample bottle 43 stored in the storage unit 4 is ensured to be accurate.

As shown in fig. 6, the transport pipe 222 includes a sample bottle stock channel 2221, a stock high-pressure gas pipe 2222, a sample bottle stock-out channel 2223, a stock-out high-pressure gas pipe 2224, a plurality of sample bottle transfer channels 2227, and a transfer high-pressure gas pipe 2228. Sample bottle warehouse entry channel 2221 is connected to warehouse entry channel mounting port 22111, sample bottle transfer channel 2227 is mounted at sample bottle transfer channel mounting port 22114, and sample bottle warehouse exit channel 2223 is mounted at warehouse exit channel mounting port 22118; the high-pressure gas pipe 2222 for warehouse entry, the high-pressure gas pipe 2224 for warehouse exit, and the high-pressure gas pipe 2228 for transfer are connected to the high-pressure gas pipe mounting port 22119, the high-pressure gas pipe mounting port 22112, and the high-pressure gas pipe mounting port 22115, respectively. Sample bottle storage channels 2221 and storage high-pressure gas pipelines 2222 are symmetrically arranged on sample bottle transfer bins 2211. The sample bottle delivery channel 2223 and the delivery high pressure gas line 2224 are symmetrically mounted on the sample bottle transfer bin 2211. Control valves are arranged on the high-pressure gas pipelines.

As shown in fig. 7, in the sample bottle storage channel 2221, an interface 22211 and a capture port 22213 are respectively provided at two ends of the pipe 22212, the interface 22211 is in butt joint with the storage channel mounting port 22111, and the capture port 22213 is used for butt joint with an upper port of the storage tube 42 in the sample storage unit 4. The sample bottle discharge path 2223 is configured in the same manner as the sample bottle storage path 2221, but has a catch port connected to the interface 711 of the sample bottle transfer tube 71 in the transition transfer mechanism 7.

As shown in fig. 8, the sample bottle transfer channel 2227 is provided with an interface 22271 and a catch opening 22273 at both ends of the pipe 22272, respectively, the interface 22271 is abutted with the warehouse-in channel mounting opening 22114, and the catch opening 22273 is used for being abutted with the upper port of the storage tube 42 in the sample storage unit 4.

As shown in fig. 9, the warehouse entry high-pressure gas pipeline 2222 is provided with an interface 22221 and a gas inlet 22223 at both ends of the pipeline 22222, respectively, and the interface 22221 is in butt joint with the high-pressure gas pipeline mounting port 22112. The ex-warehouse high-pressure gas line 2224 and the transfer high-pressure gas line 2228 are both identical in structure to the in-warehouse high-pressure gas line 2222.

The sample bottle access drive mechanism 23 is provided with four sets including a warehouse-in drive mechanism 231, a warehouse-out drive mechanism 232, a transfer drive mechanism 233, and a fourth drive mechanism 234, as shown in fig. 10. The warehouse-in driving mechanism 231 is used for driving the sample bottle warehouse-in channel 2221, and the warehouse-out driving mechanism 232 is used for driving the sample bottle warehouse-out channel 2223. The transfer driving mechanism 233 and the fourth driving mechanism 234 are used for the sample bottle transfer paths 2227, and since there are a plurality of sample bottle transfer paths 2227 and they are divided on both sides, the fourth driving mechanism 234 takes on driving work of other sample bottle transfer paths 2227 for the purpose of improving efficiency. The four sets of driving mechanisms can execute tasks (not exclusive to which channel is convenient to improve efficiency) according to the working requirement and the nearby principle, drive the corresponding channel to a preset position and complete related tasks such as warehouse-out, warehouse-in, warehouse-back and the like in a matched mode. Each set of driving mechanism is shown in fig. 11, and takes the warehouse-in driving mechanism 231 as an example, and comprises a main driving mechanism 2311 and a secondary driving mechanism 2312, wherein the secondary driving mechanism 2312 is connected to the power output end of the main driving mechanism 2311. The main driving mechanism 2311 employs a screw-nut pair moving mechanism, a screw is mounted on the bracket 21 and connected to a driving motor, and a nut is connected to the screw. The auxiliary driving mechanism 2312 adopts an electric telescopic gripper, which is of the prior art and comprises an electric telescopic frame 2313 and a gripper 2314, wherein the electric telescopic frame 2313 is connected to a nut in the main driving mechanism, and the gripper 2314 is connected to the tail end of the electric telescopic frame 2313. Each channel (sample bottle warehouse-in channel 2221, sample bottle warehouse-out channel 2223, sample bottle transfer channel 2227) is grabbed by a gripper 2314 of the corresponding driving mechanism, and is driven to be in butt joint with related components through the cooperation of the main driving mechanism 2311 and the auxiliary driving mechanism 2312.

The operation of the sample bottle friction access mechanism 2 described above is as follows.

The sample bottles 43 enter the sample bottle transfer bin 2211 through any sample bottle transfer channel 2227 or sample bottle delivery channel 2223, and the high pressure gas in the transfer high pressure gas channel 2228 pushes the sample bottles 43 out of the inlet position and onto the transport belt 2213, and the sample bottles 43 move in the sample bottle transfer bin 2211 following the transport belt 2213. Meanwhile, the high-pressure gas entering the sample bottle transfer bin 2211 through the transfer high-pressure gas channel 2228 also plays a role in assisting side thrust, corrects the tilting phenomenon of the sample bottles 43, and prevents blockage caused by tilting of the individual sample bottles 43.

When a sample vial 43 needs to be taken out of the warehouse (the sample vial 43 is taken out of the warehouse 42), the transfer drive mechanism 233 drives the lower port of one sample vial transfer passage 2227 to interface with the upper port of the warehouse 42 corresponding to the sample vial taken out of the warehouse. The sample bottle discharge path 2223 is driven by the discharge drive mechanism 232 to connect with the sample bottle transfer tube 71 in the transition transfer mechanism 7. The sample bottle 43 enters the sample bottle transfer passage 2227 from the storage tube 42 under the action of the automatic sealing mechanism 5 and the gas transmission mechanism 6, enters the sample bottle transfer bin 2211 from the sample bottle transfer passage 2227, and is placed on the transport belt 2213.

When the sample bottle 43 moves in the sample bottle transfer bin 2211 along with the conveying belt 2213, the information is captured by the 2 recognition devices 2226 and the recognition devices 2225 in sequence, and is subjected to data analysis and processing, if the sample bottle 43 is judged to be the sample bottle 43 to be taken, when the sample bottle 43 arrives at the position of the delivery channel mounting port 22118 and the position of the high-pressure gas channel mounting port 22112 (the delivery channel mounting port 22118 and the high-pressure gas channel mounting port 22112 are symmetrical to the sample bottle transfer bin 2211, the sample bottle delivery channel 2223 is connected to the delivery channel mounting port 22118, the high-pressure gas pipeline 2224 is connected to the high-pressure gas channel mounting port 22112), the control valve of the high-pressure gas pipeline 2224 is started, and the high-pressure gas blows the sample bottle 43 into the sample bottle delivery channel 2223 through the high-pressure gas channel mounting port 22112, then enters the transition transfer mechanism 7 through the sample bottle transfer pipe 71, and the delivery flow is completed in the transition transfer mechanism 7.

If it is determined that the sample bottle 43 is not the sample bottle 43 to be taken, the sample bottle 43 continues to move forward on the conveyor 2213, and when the sample bottle reaches the warehouse entry port 22111, the control valve on the warehouse entry high-pressure gas pipeline 2222 is opened to blow the sample bottle 43 into the sample bottle warehouse entry port 2221, and the sample bottle 43 enters the storage pipe 42 again, so that the warehouse entry process is completed.

When it is necessary to store the sample bottles 43 in the sample bottle storage unit 4 (at the time of storage), the sample bottles 43 are first introduced into the sample bottle transfer warehouse 2211 as described in the operation of the transition transfer mechanism 7. When the sample bottle 43 moves in the sample bottle transfer bin 2211 along with the conveying belt 2213, the information of the sample bottle 43 is captured by the 2 recognition devices 2226 and 2225 in sequence, and is subjected to data analysis and processing, if the information of the sample bottle 43 is judged to be not correct, when the sample bottle 43 arrives at the position of the delivery channel mounting port 22118 and the position of the high-pressure gas channel mounting port 22112 (the delivery channel mounting port 22118 and the high-pressure gas channel mounting port 22112 are symmetrical to the sample bottle transfer bin 2211, the sample bottle delivery channel 2223 is connected to the delivery channel mounting port 22118, the high-pressure gas pipeline 2224 is connected to the high-pressure gas channel mounting port 22112), the control valve of the high-pressure gas pipeline 2224 is started, the high-pressure gas blows the sample bottle 43 into the sample bottle delivery channel 2223 through the high-pressure gas channel mounting port 22112, and then enters the transition transfer mechanism 7 through the sample bottle transfer pipe 71, and the delivery flow (information is not correct) is completed in the transition transfer mechanism 7, and the withdrawal cannot be stored. If it is determined that the sample bottle 43 is a sample bottle 43 to be stored, the sample bottle 43 continues to move forward on the conveyor 2213, and when the sample bottle reaches the storage passage mounting port 22111, the control valve on the storage high-pressure gas pipeline 2222 is opened to blow the sample bottle 43 into the sample bottle storage passage 2221, and the sample bottle 43 enters the storage pipe 42 again, thereby completing the storage process.

2. Sample bottle storage unit

As shown in fig. 12, the sample bottle storage unit 4 adopts a bundling tube structure, and comprises a sealing box 41, wherein a refrigerating medium exchange port 411 is formed in the side wall of the sealing box 41, storage tubes 42 are vertically distributed in the sealing box 41, the storage tubes 42 are fixed through tube plates at the upper end and the lower end of the sealing box 41, and the upper end and the lower end of the storage tubes 42 are all open. The storage tube 42 is used to store a sample bottle 43, as shown in fig. 13. Function of the seal box 41: firstly, an independent and stable storage temperature and humidity environment is provided for a sample storage unit, and the environment temperature can be lower than 25 ℃ below zero; and secondly, the sample storage unit 4 is isolated from other mechanisms or units, so that the sample storage unit has an exclusive temperature and humidity environment.

3. Automatic sealing mechanism

As shown in fig. 14, the automatic sealing mechanism 5 includes a heat insulating frame 51, and an upper partition plate 52, a middle partition plate 54, a sealing ball 53, and a lower partition plate 55 that are connected together from top to bottom.

As shown in fig. 15, the upper partition plate 52 has upper partition plate through holes 521 distributed therein, and a plurality of ventilation grooves 522 are engraved in the inner wall of the upper partition plate through holes. The upper diaphragm through hole 521 has a diameter smaller than that of the sealing ball 53, and serves to restrict the sealing ball 53. The vent groove 522 has an circumscribed circular diameter corresponding to the circular through hole 541, and is a passage for high-pressure gas to enter the storage tube 42.

As shown in fig. 16, circular through holes 541 are distributed in the middle partition plate 54, and sealing balls 53 are provided in the circular through holes 541. The circular through hole 541 has a diameter larger than that of the sealing ball 53, and is a sealing ball floating region, and also a passage through which high-pressure gas flows.

As shown in fig. 17, the lower partition plate 55 is provided with lower partition plate through holes 551 distributed thereon and is subjected to arc chamfering to form an arc spherical surface 552. The diameter of the arc-shaped spherical surface 552 is not larger than that of the sealing ball 53, when the sealing ball 53 loses the external pressure, the sealing ball falls into the spherical surface 552 by self gravity to seal the lower partition plate through hole 551.

The diameter of the sealing ball 53 is smaller than the inner diameter of the circular through hole 551 and larger than the upper and lower partition through holes 521 and 551, and the distribution of the upper, circular through holes 541 and lower partition through holes 551 is identical to that of the storage tubes in the sample bottle storage unit (coaxial up and down, one-to-one correspondence).

4. Air conveying mechanism

As shown in fig. 18 and 19, the gas delivery mechanism 6 includes a frame 61, a gas delivery nozzle 62, a control valve 63, a gas storage chamber 64, a gas delivery passage 65, and a transmission device 66, and a plurality of valve ports 642 and 1 gas delivery port 643 are provided on a gas storage chamber 641. The transmission device 66 is installed on the frame 61, a screw-nut pair moving mechanism is adopted, a screw is installed on the frame 61, a nut is connected to the screw, the gas storage bin 64 is connected to the nut, and the gas delivery nozzle 62 is connected with a valve interface 642 of the gas storage bin 64 through the control valve 63. The gas transmission channel 65 is connected with the gas transmission interface 643 of the gas storage bin 64, and the gas transmission channel 65 transmits high-pressure gas into the gas storage bin 64. The actuator 66 moves the gas storage 64 to move the gas delivery nozzle 62 to a predetermined position.

The operation process of the gas transmission mechanism 6 and the automatic sealing mechanism 5 is as follows:

the gas delivery nozzles 62 are in butt joint with a row of lower partition through holes 551 of the lower partition 55 at corresponding positions under the control of the transmission mechanism 66. High-pressure gas enters one or more through holes 551 of the corresponding lower partition plate on the lower partition plate 55 through the gas delivery nozzles 62, under the action of the high-pressure gas, the sealing balls 53 are in a suspended state in the corresponding middle channels 541 of the middle partition plate 54, the sealing effect is disabled, and the high-pressure gas enters one or more storage pipes 42 through the corresponding ventilation grooves 522 on the upper partition plate 52, so that the sample bottles 43 in the storage pipes 42 are pushed to move upwards. When the air pressure is removed, the sealing ball 53 falls down into the arc-shaped spherical surface 552 of the lower partition 55 by its own weight, and plays a role of autonomous sealing. The density of the sealing ball 53 itself is sufficiently high that the sealing ball 53 cannot be suspended without the high pressure air flow.

5. Transition transfer mechanism

As shown in fig. 20, the transition transfer mechanism 7 includes a sample bottle transfer tube 71 and a transition transfer chamber 72, the sample bottle transfer tube 71 is connected above the transition transfer chamber 72, a rear cover plate 73 is provided at the rear of the transition transfer chamber 72, an openable front cover plate 74 is provided at the front, and a sample bottle storage port 75 is provided on the front cover plate 74.

As shown in fig. 21, the sample bottle transfer tube 71 has a port 711 and a sample bottle inlet/outlet 713 at both ends of a transfer tube body 712. The transfer tube 712 passes through the mounting aperture 7222 into the transition chamber 722. The sample bottle transfer tube 71 interfaces with the ex-warehouse sample bottle transfer channel 2223 in the sample bottle friction access mechanism 2 or interfaces with the sample bottle transfer channel 2227. Sample bottles 43 enter and exit transition bins 72 through sample bottle access 713. The sample bottle 43 is transferred between the transition mechanism 7 and the sample bottle friction access mechanism 2 through the sample bottle transfer tube 71.

As shown in fig. 22, the transition-transfer bin 72 is internally provided with a three-dimensional moving platform 721, a transition bin 722, a sample bottle tray 723, a transfer bracket 724, and a gas pipe 725. The three-dimensional moving platform 721 is a prior art and is mounted within the transition bin 722. The transfer bracket 724 is installed at the power output end of the three-dimensional moving platform 721, and is driven by the three-dimensional moving platform 721 to perform three-dimensional operation up and down, left and right, front and back, and reach the required position. Sample bottle tray 723 is placed on pallet 7223 in transition bin 722. As shown in fig. 23, the transition bin 722 includes a bin frame 7221 and a pallet 7223, and a mounting hole 7222 of the sample bottle transfer tube 71 is provided at an upper end of the bin frame 7221, and the mounting hole 7222 is connected to the sample bottle transfer tube 71. The pallet 7223 is horizontally aligned and fixed in the magazine 7221 for temporarily storing sample bottle trays 723. The gas pipe 725 is disposed on the side wall of the transition chamber 722 (or may be disposed on the back cover 73), and one end in the transition chamber 722 is disposed directly below the sample bottle inlet/outlet 713 of the sample bottle transfer tube 71, and the distance between the gas pipe 725 and the sample bottle transfer tube 71 is identical to the height of the sample bottle tray 723. The other end of the air delivery pipe 725 is connected to one of the air delivery nozzles 62 in the air delivery mechanism 6.

As shown in fig. 24, a sample bottle tray 723 is provided with a sample bottle placement hole 7232 in a sample bottle tray 7231, and a transport notch 7233 is provided in the bottom of the sample bottle tray 7231. The sample bottle placing hole 7232 is a stepped through hole, and has a large upper diameter and a small lower diameter, and the sample bottle 43 is placed on the upper portion, and the lower portion is used for holding the sample bottle 43 and entering gas to blow out the sample bottle 43.

As shown in fig. 25, the transfer bracket 724 includes a carrying claw 7241, a mounting surface 7242, and a positioning table 7244. One side of the carrying claw 7241 is a positioning table 7244 for restricting the placement position of the sample bottle tray 7231. The lower bottom surface of the positioning table 7244 is a mounting surface 7242 for connection to a three-dimensional moving platform 721. The carrying claw 7241 is provided with an air vent 7243, and the air vent 7243 corresponds to the sample bottle placement hole 7232 in the sample bottle tray 7231. The carrying claw 7241 blocks the sample bottle placing hole 7232 in the sample bottle tray body 7231 above the sample bottle tray 723 when it is placed on the transfer bracket 724, and the gas vent 7243 is provided so that gas can enter the sample bottle placing hole 7232 through the gas vent 7243. The carrying claw 7241 is inserted into a carrying notch 7233 in the bottom of the carrying sample bottle tray 723, and the sample bottle tray 7231 is lifted up and moves three-dimensionally in the transition bin 722 following the three-dimensional moving platform 721.

As shown in FIG. 26, a gas delivery pipe 725 has a gas delivery port 7251 and a gas delivery interface 7253 at both ends of a gas delivery pipe body 7252. The gas pipe 7252 is provided on the back cover plate 73, and the gas supply port 7251 is provided immediately below the sample bottle inlet/outlet 713, and the distance between the gas supply port 7251 and the sample bottle inlet/outlet 713 is equal to the height of the sample bottle tray 723 (the height of the conveying claw 7241 is equal to the height of the conveying notch 7233). The gas delivery interface 7253 is connected to a gas delivery nozzle 62 in the gas delivery mechanism 6.

The operation of the above-described transition mechanism 7 is as follows.

The sample bottles 43 are placed in the sample bottle placing holes 7232 on the sample bottle tray 723, the sample bottle tray 723 is moved in and out of the transition rotation mechanism 7 by the sample bottle storage port 75, and the transport of the sample bottle tray 723 between the sample bottle taking and placing port 75 and the bin 7221 is realized by the three-dimensional moving platform 721.

When the sample bottles 43 enter the unloading program, the sample bottles 43 enter the sample bottle transfer tube 71 through the sample bottle unloading channel 2223, the sample bottles 43 continuously come out from the sample bottle inlets 713, the sample bottle trays 723 continuously move under the drive of the three-dimensional moving platform 721, the empty sample bottle placing holes 7232 receive the sample bottles 43 from the sample bottle inlets 713, and the sample bottles 43 are placed into the sample bottle placing holes 7232 one by one. When the sample bottle tray 723 is full of sample bottles 43, or the number of the sample bottles 43 taken out meets the requirement (the sample bottle tray 723 is not full of sample bottles 43 yet), the three-dimensional moving platform 721 drives the sample bottle tray 723 to be temporarily placed on the pallet 7223, or to be moved out of the transition rotation mechanism 7 through the sample bottle storage port 75, so as to finish the task of leaving a warehouse.

When it is necessary to store the sample bottles 43 in the sample bottle storage unit 4 (at the time of storage), the sample bottles 43 are first placed in the sample bottle placing holes 7232, and the sample bottle trays 723 are placed in the transition transfer bins 72 through the sample bottle storage ports 75 and placed on the pallet 7223. The three-dimensional moving platform 721 drives the carrying claw 7241 into the carrying notch 7233 at the bottom of the sample bottle tray 723. To increase the speed of entry of the sample bottle tray 723 into the transition mechanism 7, if there are too many sample bottle trays 723 stored at a time, the sample bottle tray 723 may be first placed on the pallet 7223. When all the sample bottle trays 723 to be stored enter the transition transfer mechanism 7, the sample bottle trays 723 are moved to a predetermined position (at the sample bottle inlet 713) by the three-dimensional moving platform 721. The second access drive mechanism 232 drives the sample bottle transfer channel 2227 (or the third access drive mechanism drives the grip opening 22273 of the sample bottle transfer channel 2227) to interface with the interface 711 of the sample bottle transfer tube 71 in the transition transfer mechanism 7. At this time, the air supply port 7251 of the air pipe 725, the sample bottle placement hole 7232 of the sample bottle tray 723 on which the corresponding sample bottle 43 is placed, and the sample bottle inlet/outlet 713 of the sample bottle transfer pipe 71 are aligned. The control valve 63 controlling the gas delivery nozzle 62 connected to the gas delivery pipe 725 is opened, and high-pressure gas is blown to the sample bottle placing hole 7232 through the gas delivery port 7253 of the gas delivery pipe 725, and the sample bottle 43 in the sample bottle placing hole 7232 is blown into the sample bottle transfer pipe 71 and enters the sample bottle transfer bin 2211 through the sample bottle transfer passage 2227. If the sample bottle placement hole 7232 is located directly below the carrying claw 7241, the gas blown out from the gas delivery port 7253 of the gas delivery pipe 725 directly or through the gas delivery hole 7243 enters the sample bottle placement hole 7232, and the sample bottle is blown out from the sample bottle placement hole 7232 and enters the sample bottle transfer passage 71. Thus, sample bottles 43 are fed one by one through sample bottle transfer channel 71 into sample bottle transfer channel 2227 and into sample bottle transfer magazine 2211. Finally, the sample bottles are put into storage according to the storage process in the friction access mechanism 2.

The operation process of the whole biomedical sample multichannel friction access system is as follows.

Firstly, a closed channel for transferring a sample bottle is constructed, and corresponding pipelines, interfaces and nozzles are quickly butted by depending on a related sample bottle access driving mechanism 23 to form the closed channel. Such as: the closed channel in the process of discharging is that the discharging driving mechanism 232 drives the sample bottle discharging channel 2223 to be connected with the sample bottle transferring pipe 71 in the transition transferring mechanism 7, the transferring driving mechanism 233 drives the laying and grabbing port 22273 of the sample bottle transferring channel 2227 to be in butt joint with the upper port of the storage pipe 42 corresponding to the discharged sample bottle, and the gas transmission nozzle 62 is in butt joint with the corresponding lower port of the storage pipe 42. Then according to the relevant recognition device, the sample bottle 43 is accurately caught, and accurate ex-warehouse, return-warehouse and warehouse-in of the sample bottle 43 are realized.

When a specific sample bottle 43 is taken out (out of the warehouse), the transfer driving mechanism 233 drives the grip opening 22273 of one sample bottle transfer passage 2227 to be in butt joint with the upper port of the storage tube 42 corresponding to the sample bottle to be out of the warehouse, and the out-warehouse driving mechanism 232 drives the sample bottle out-warehouse passage 2223 to be connected with the sample bottle transfer tube 71 in the transition transfer mechanism 7. The gas delivery nozzle 62 is in butt joint with a row of lower partition plate through holes 551 of the lower partition plate 55 in the automatic sealing mechanism 5 corresponding to the lower port of the storage pipe 42 where the sample bottle 43 is stored under the control of the transmission mechanism 66, and opens one or more control valves 63, high-pressure gas is delivered to the corresponding storage pipe 42, the sample bottle 43 is delivered to the sample bottle transfer channel 2227, then enters the sample bottle transfer bin 2221 through the sample bottle transfer channel 2227 and is placed on the transport belt 2213, the high-pressure gas enters the sample bottle transfer bin 2221 through the transfer high-pressure gas pipeline 2228, the boosted sample bottle 43 moves laterally together with the transport belt 2213, the information of the cover and the bottom of the sample bottle 43 is captured when the information of the sample bottle 43 reaches the identification area of the identification device 2225, the information of the sample bottle 43 on the body is captured, the information of the sample bottle 43 captured twice is compared and judged, if the sample bottle 43 is the sample bottle 43 to be taken, then leaves the high-pressure gas pipeline 2224 through the sample bottle transfer channel 2227, the sample bottle 43 leaves the sample bottle transfer channel 2223 and enters the transfer mechanism through the transition pipe 2217, and the transition mechanism is completed after the sample bottle 43 leaves the transfer channel 2217. If the sample bottle 43 is not the sample bottle 43 to be taken, the sample bottle 43 continues to move forward, the gas is injected into the high-pressure gas pipeline 2222 when the sample bottle 43 reaches the working area of the high-pressure gas pipeline 2222, and the sample bottle 43 enters the warehouse-returning process from the sample bottle warehouse-in channel 2221.

When the sample bottles 43 need to be stored in the sample bottle storage unit 4 (during storage), the sample bottles 43 are firstly put into the sample bottle transfer bin 2211 in the sample bottle friction access mechanism 2 according to the operation process of the transition transfer mechanism 7, and then are stored according to the storage flow in the sample bottle friction access mechanism 2.

Specific examples are given below.

Sample bottle storage unit 4

The temperature and humidity control box 1 is designed to be 1200mm long, 1200mm wide and 1800mm high, the thickness of the heat preservation layer is 50mm, and a temperature and humidity control system is installed.

The sample bottle storage unit 4 is designed to be 1000mm long, 800mm wide and 1000mm high. The storage tube 42 is made of a circular tube of organic glass, and has an inner diameter phi of 20mm, an outer diameter phi of 24mm and a length of 900mm. The upper tube plate and the lower tube plate are 1000mm long, 800mm wide and 10mm thick, are made of organic glass, are provided with 33 uniformly distributed stepped holes on the long side and 25 uniformly distributed stepped holes on the short side, are provided with 825 uniformly distributed stepped holes in total, have the hole spacing of 30mm, and have the large holes phi 24mm and the small holes phi 20mm. Firstly, the storage tubes are inserted into holes with the diameter of 24mm of the lower tube plate one by one, then the storage tubes are inserted into holes with the diameter of 24mm of the upper tube plate one by one, and the storage tube bundles are manufactured. The heat preservation layer is arranged around the longitudinal direction of the storage tube bundle, the thickness of the heat preservation layer is 50mm, 4 refrigerating medium exchange holes with phi 100 are reserved on two symmetrical sides, the distance between the two identical side holes is 400mm, the refrigerating medium exchange holes are used for installing cooling medium exchange ports, and the manufacturing of the sample bottle storage unit is completed.

Second, sample bottle rubs the access mechanism

1. Sample bottle transfer bin manufacturing

1) A rectangular groove with a wall thickness of 5mm, a length of 360mm, a width of 50mm and a height of 30mm is manufactured, and a groove with a diameter of 300 mm is formed on one wide side, and the groove is complemented by a conveying belt to form a complete cavity.

2) Holes of phi 10 are opened at the corresponding positions for installing the corresponding channels. A slot of 30 x 20mm is made in the other wide face for mounting the identification means.

2. Sample bottle transport mechanism manufacture

1) 2 Drums of 60mm in diameter and 40mm in length were made for mounting the conveyor belt and machining a central hole of 30mm in diameter.

2) The central axis is designed to be phi 30mm.

3) 2 Supports are designed, the width of the bottom surface of each support is 60mm, the width of the upper surface of each support is 30mm, the height of each support is 70mm, the wall thickness of each support is 10mm, a phi 30mm central hole is formed from the bottom surface of each support by 50mm and used for installing a rotary drum, and 2 phi 10mm holes are formed in the bottom surface of each support and used for fixed installation.

4) The conveyer belt is a rubber belt with the thickness of 5mm and the width of 30mm.

5) The 2 support centers were fixed 300mm apart, the conveyor belt was properly mounted to the drum, and the servo motor was mounted on a center shaft.

And (5) completing the manufacture of the sample bottle conveying mechanism.

Third, sample bottle access unit fabrication

1. The conveying belt is inlaid on the notch of the sample bottle transporting bin and is integrated with the sample bottle transporting mechanism.

2. And installing the sample bottle warehouse-in channel, the sample bottle warehouse-out channel, the sample bottle transfer channel, 3 high-pressure gas pipelines and 3 sets of identification devices on the corresponding ports.

Fourth, automatic sealing mechanism 5

1) The heat insulation frame is manufactured, the size is 1000 x 800 x 35mm, and the thickness of the heat insulation layer is 50mm.

2) The upper partition plate is 1000mm long, 800mm wide and 10mm thick, is made of engineering plastics, is provided with 825 ventilation slot through holes uniformly distributed, corresponds to 825 holes of the storage unit tube bundle one by one, is 140mm from the center to the edge of the outer side hole, is 10mm in diameter of the inscribed circle of the through holes, is 15 x 2mm in size of the ventilation slots, and is provided with 6 ventilation slots uniformly distributed.

3) The pneumatic channel is 1000mm long, 800mm wide and 15mm thick, is made of engineering plastics, is uniformly provided with 825 ventilation slot through holes, corresponds to 825 holes of the upper partition plate one by one, and has an outer side hole center distance of 140mm from the side line and a through hole diameter phi of 15mm.

4) The lower partition plate is 1000mm long, 800mm wide and 10mm thick, is made of stainless steel, is uniformly provided with 825 ventilation slot through holes, corresponds to 825 holes of the upper partition plate and the middle partition plate one by one, is 140mm from the center of the outer side hole to the side line, is 10mm in diameter of the through hole, and is provided with an arc chamfer R2.

5) The diameter phi of the gas sealing ball is 12mm.

6. The lower partition plate, the sealing ball, the middle partition plate and the upper partition plate are sequentially arranged in the heat insulation frame and are connected together through fasteners, and the gas sealing mechanism is assembled.

The refrigeration control unit, the gas transmission mechanism, the gas sealing mechanism, the sample bottle storage unit, the transition transfer mechanism and the sample bottle access mechanism are assembled into a whole through the auxiliary connecting piece and are placed into the temperature control mechanism, and the related executing mechanisms are respectively installed, so that the multi-channel friction type sample bottle access system is assembled.

Fifth, transition transfer mechanism 7

1) Front cover plate, design 1000 x 1200 x 10mm, open 300 x 100mm mouth centrally.

2) The transition bin is 1000 x 1200 x 300mm, and a phi 22mm hole is formed in the middle of the upper end.

3) The back cover plate is 1000 x 1200 x 10mm in design, and a phi 12mm hole is formed in the center of the back cover plate, 30mm away from the bottom.

4) The pallet was 200 x 140 x 10mm in design.

5) The tray is designed to 240 x 140 x 40mm, 45 sample bottles are uniformly distributed with through holes of the placing holes, the placing holes are stepped holes, wherein the upper dimension phi=20 mm, the depth is 30mm, the lower dimension phi 10mm and the depth is 10mm, two notches of 30 x 5mm are symmetrically formed in the other surface, and the distance is 140mm.

6) The transfer bracket is designed into a concave shape with the size of 200 mm, and a boss with the size of 200 mm and the size of 10mm is manufactured at the bottom of the concave shape and used for limiting the position of the tray. The length of each claw is 140mm, the width of each claw is 30mm, the thickness of each claw is 5mm, the distance between the two claws is 140mm (corresponding to the notch of the tray), 5 phi 10mm holes are respectively formed in the two claws, and the positions of the holes correspond to the transverse positions of the holes of the tray. A boss of 30 x 50 x 20mm is manufactured at the bottom edge of the concave shape and is used for connecting with a three-dimensional moving platform.

7) The supporting plate and the three-dimensional moving platform are sequentially arranged on the transition bin, the transfer bracket is connected to the three-dimensional moving platform, the front cover plate and the rear cover plate are connected with the transition bin, and the transition transfer mechanism is manufactured.

Claims (10)

1. The multichannel friction access system for the biological medicine samples is characterized by comprising a sample bottle friction access mechanism, a sample bottle storage unit, an automatic sealing mechanism, a gas transmission mechanism and a transition transfer mechanism which are sequentially arranged from top to bottom, wherein the sample bottle friction access mechanism, the sample bottle storage unit, the automatic sealing mechanism and the gas transmission mechanism are sequentially arranged from top to bottom;

the sample bottle friction access mechanism comprises a bracket, a sample bottle access unit and a sample bottle access driving mechanism, wherein the sample bottle access driving mechanism is arranged on the bracket; the sample bottle access unit comprises a sample bottle conveying mechanism and a conveying pipeline, and the conveying pipeline is connected to the sample bottle conveying mechanism; the sample bottle conveying mechanism comprises a support, a sample bottle conveying bin, a conveying belt, belt wheels and a servo motor, wherein two belt wheels are arranged on the support, one belt wheel is connected with the servo motor, and the conveying belt is arranged on the two belt wheels and is embedded in the sample bottle conveying bin; the transport pipeline comprises a sample bottle warehousing channel, a warehousing high-pressure gas pipeline, a sample bottle ex-warehouse channel, an ex-warehouse high-pressure gas pipeline, a sample bottle transfer channel and a transfer high-pressure gas pipeline, and each high-pressure gas pipeline is provided with a control valve; the sample bottle access driving mechanism is at least provided with one set, and drives the sample bottle transfer channel or the sample bottle warehouse-in channel to be in butt joint with the sample bottle storage unit, or drives the sample bottle warehouse-out channel to be in butt joint with the transition transfer mechanism.

2. The biomedical sample multichannel friction access system of claim 1, wherein the sample bottle transfer bin is provided with three identification devices, two of which are symmetrically arranged.

3. The biomedical sample multichannel friction access system according to claim 1, wherein the sample bottle warehouse-in channel and the warehouse-in high-pressure gas pipeline are symmetrically arranged on the sample bottle transfer warehouse; the sample bottle delivery channel and the delivery high-pressure gas pipeline are symmetrically arranged on the sample bottle transfer bin.

4. The biomedical sample multichannel friction access system according to claim 1, wherein the access driving mechanism comprises a main driving mechanism and a secondary driving mechanism, wherein the secondary driving mechanism is connected to the power output end of the main driving mechanism; the main driving mechanism adopts a screw-nut pair moving mechanism; the auxiliary driving mechanism adopts an electric telescopic gripper, and comprises an electric telescopic frame and a gripper, wherein the electric telescopic frame is connected to the power output end of the main driving mechanism, and the gripper is connected to the tail end of the electric telescopic frame.

5. The multi-channel friction access system for biomedical samples according to claim 1, wherein the storage unit for the sample bottles adopts a bundling tube structure and comprises a sealing box, a refrigerating medium exchange port is arranged on the side wall of the sealing box, storage tubes are vertically distributed in the sealing box and are fixed through tube plates at the upper end and the lower end of the sealing box, and the upper end and the lower end of the storage tubes are both open.

6. The biomedical sample multi-channel friction access system according to claim 1, wherein the automatic sealing mechanism comprises a heat insulation frame, and an upper partition, a middle partition and a lower partition which are connected together from top to bottom in the heat insulation frame; the upper partition plate is provided with upper through holes, and ventilation grooves are carved on the inner walls of the upper through holes; round through holes are distributed on the middle partition plate, sealing balls are arranged in the round through holes, and the diameter of the round through holes is larger than that of the sealing balls; the lower partition plate is provided with lower through holes; the diameter of the sealing ball is smaller than the inner diameter of the round through hole and larger than the inner diameters of the upper through hole and the lower through hole, and the distribution mode of the upper through hole, the round through hole and the lower through hole is consistent with the distribution mode of the storage pipes in the sample bottle storage unit.

7. The multi-channel friction access system for biomedical samples according to claim 1, wherein the gas transmission mechanism comprises a frame, a gas transmission nozzle, a control valve, a gas storage bin, a gas transmission channel and a transmission device, wherein the transmission device is arranged on the frame, the gas storage bin is connected to the transmission device, the gas transmission nozzle is connected with the gas storage bin through the control valve, and the gas transmission channel is connected with the gas storage bin.

8. The biomedical sample multichannel friction access system according to claim 1, wherein the transition transfer mechanism comprises a sample bottle transfer tube, a sample bottle inlet and outlet, a transition transfer bin and a gas transmission tube, and the sample bottle transfer tube is connected above the transition transfer bin; the transition transfer bin is internally provided with a three-dimensional moving platform, a transition bin, a sample bottle tray and a transfer bracket, and the transfer bracket is arranged at the power output end of the three-dimensional moving platform; the transition bin comprises a bin frame and a supporting plate, the supporting plate is fixed in the bin frame, and a sample bottle tray is arranged on the supporting plate; the gas pipe is arranged on the side wall of the transition bin, one end of the gas pipe in the transition bin is opposite to the port of the sample bottle transfer pipe, and the other end of the gas pipe is connected with the gas transmission mechanism.

9. The biomedical sample multichannel friction access system according to claim 8, wherein the sample bottle tray is provided with a sample bottle placing hole on the sample bottle tray body, and a carrying notch is arranged at the bottom of the sample bottle tray body; the sample bottle placing hole is a stepped through hole, the diameter of the upper part is large, and the diameter of the lower part is small.

10. The biomedical sample multichannel friction access system according to claim 8, wherein the transfer bracket is provided with a carrying claw, and the carrying claw is provided with an air guide hole.