CN118043325A - 8-氧-3-氮杂二环[3.2.1]辛烷类化合物或其盐及其制备方法和用途 - Google Patents
8-氧-3-氮杂二环[3.2.1]辛烷类化合物或其盐及其制备方法和用途 Download PDFInfo
- Publication number
- CN118043325A CN118043325A CN202280052257.4A CN202280052257A CN118043325A CN 118043325 A CN118043325 A CN 118043325A CN 202280052257 A CN202280052257 A CN 202280052257A CN 118043325 A CN118043325 A CN 118043325A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- mmol
- azabicyclo
- compound
- oxa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110860428.3 | 2021-07-27 | ||
| CN202110860428 | 2021-07-27 | ||
| CN202210779302 | 2022-07-01 | ||
| CN202210779302.8 | 2022-07-01 | ||
| PCT/CN2022/107932 WO2023005928A1 (zh) | 2021-07-27 | 2022-07-26 | 8-氧-3-氮杂二环[3.2.1]辛烷类化合物或其盐及其制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118043325A true CN118043325A (zh) | 2024-05-14 |
Family
ID=85060847
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280052257.4A Pending CN118043325A (zh) | 2021-07-27 | 2022-07-26 | 8-氧-3-氮杂二环[3.2.1]辛烷类化合物或其盐及其制备方法和用途 |
| CN202210884665.8A Active CN115677730B (zh) | 2021-07-27 | 2022-07-26 | 8-氧-3-氮杂二环[3.2.1]辛烷类化合物或其盐及其制备方法和用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210884665.8A Active CN115677730B (zh) | 2021-07-27 | 2022-07-26 | 8-氧-3-氮杂二环[3.2.1]辛烷类化合物或其盐及其制备方法和用途 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240294550A1 (https=) |
| EP (1) | EP4378943A4 (https=) |
| JP (1) | JP2024527044A (https=) |
| KR (1) | KR20240041354A (https=) |
| CN (2) | CN118043325A (https=) |
| AU (1) | AU2022316931A1 (https=) |
| CA (1) | CA3227713A1 (https=) |
| IL (1) | IL310412A (https=) |
| TW (1) | TW202321256A (https=) |
| WO (1) | WO2023005928A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202602891A (zh) * | 2024-03-28 | 2026-01-16 | 大陸商勵締（杭州）醫藥科技有限公司 | 具有mTOR抑制活性的有機化合物及其用途 |
| TW202545519A (zh) * | 2024-05-15 | 2025-12-01 | 俄羅斯聯邦商拜奧卡德聯合股份公司 | 共濟失調毛細血管擴張症和Ｒａｄ３相關激酶抑制劑 |
| WO2026037494A1 (en) * | 2024-08-14 | 2026-02-19 | Eracal Therapeutics Ltd. | New compounds and their uses |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI656121B (zh) * | 2014-08-04 | 2019-04-11 | 德商拜耳製藥公司 | ２－（嗎啉－４－基）－１，７－萘啶 |
| WO2017202748A1 (en) | 2016-05-24 | 2017-11-30 | Merck Patent Gmbh | Tricyclic heterocylic derivatives |
| CN112654396B (zh) * | 2018-09-07 | 2025-07-01 | 默克专利股份公司 | 5-吗啉-4-基-吡唑并[4,3-b]吡啶衍生物 |
| AU2019373416A1 (en) * | 2018-10-30 | 2021-06-10 | Repare Therapeutics Inc. | Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as ATR kinase inhibitors |
| CN111848605B (zh) | 2019-04-30 | 2023-05-02 | 四川科伦博泰生物医药股份有限公司 | 一种取代吡啶并[3,4-b]吡嗪-2(1H)-酮化合物、其制备方法和用途 |
| CN112142744A (zh) * | 2019-06-28 | 2020-12-29 | 上海瑛派药业有限公司 | 取代的稠合杂芳双环化合物作为激酶抑制剂及其应用 |
| KR20220035925A (ko) * | 2019-07-22 | 2022-03-22 | 리페어 세라퓨틱스 인크. | Atr 키나제 억제제로서의 치환된 2-모르폴리노피리딘 유도체 |
| TW202220993A (zh) * | 2020-08-07 | 2022-06-01 | 香港商德琪研發有限公司 | Atr抑制劑及其用途 |
-
2022
- 2022-07-26 TW TW111127974A patent/TW202321256A/zh unknown
- 2022-07-26 KR KR1020247006386A patent/KR20240041354A/ko active Pending
- 2022-07-26 US US18/292,437 patent/US20240294550A1/en active Pending
- 2022-07-26 WO PCT/CN2022/107932 patent/WO2023005928A1/zh not_active Ceased
- 2022-07-26 IL IL310412A patent/IL310412A/en unknown
- 2022-07-26 EP EP22848533.0A patent/EP4378943A4/en active Pending
- 2022-07-26 AU AU2022316931A patent/AU2022316931A1/en active Pending
- 2022-07-26 JP JP2024504951A patent/JP2024527044A/ja active Pending
- 2022-07-26 CN CN202280052257.4A patent/CN118043325A/zh active Pending
- 2022-07-26 CN CN202210884665.8A patent/CN115677730B/zh active Active
- 2022-07-26 CA CA3227713A patent/CA3227713A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN115677730A (zh) | 2023-02-03 |
| EP4378943A4 (en) | 2024-12-11 |
| TW202321256A (zh) | 2023-06-01 |
| EP4378943A1 (en) | 2024-06-05 |
| CN115677730B (zh) | 2024-11-12 |
| KR20240041354A (ko) | 2024-03-29 |
| WO2023005928A1 (zh) | 2023-02-02 |
| AU2022316931A1 (en) | 2024-03-14 |
| CA3227713A1 (en) | 2023-02-02 |
| JP2024527044A (ja) | 2024-07-19 |
| IL310412A (en) | 2024-03-01 |
| US20240294550A1 (en) | 2024-09-05 |
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