CN118001363A - Traditional Chinese medicine composition for dispelling effects of alcohol and sobering up, preparation method thereof, traditional Chinese medicine preparation, jelly drink and application - Google Patents
Traditional Chinese medicine composition for dispelling effects of alcohol and sobering up, preparation method thereof, traditional Chinese medicine preparation, jelly drink and application Download PDFInfo
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- CN118001363A CN118001363A CN202410136102.XA CN202410136102A CN118001363A CN 118001363 A CN118001363 A CN 118001363A CN 202410136102 A CN202410136102 A CN 202410136102A CN 118001363 A CN118001363 A CN 118001363A
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- chinese medicine
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Abstract
The invention discloses a traditional Chinese medicine composition for dispelling the effects of alcohol and a preparation method, a traditional Chinese medicine preparation, a jelly drink and application thereof, wherein the traditional Chinese medicine composition comprises the following substances in mass: 15-60 g of semen hoveniae, 10-40 g of mung bean, 10-40 g of sea buckthorn, 10-40 g of dried orange peel, 15-60 g of mulberry, 5-10 g of turmeric and 10-20 g of hawthorn. The invention combines seven medicinal materials with homology of medicine and food, so that the traditional Chinese medicine composition for dispelling the effects of alcohol and sobering up can promote in vivo ethanol decomposition through various ways, lighten the damage of alcohol to human bodies, particularly to liver, cardiovascular and cerebrovascular diseases and spleen and stomach, and has the health care effects of liver, cardiovascular and cerebrovascular diseases and spleen and stomach for people without drinking.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines and health-care foods, in particular to a traditional Chinese medicine composition for dispelling the effects of alcohol and a preparation method, a traditional Chinese medicine preparation, a jelly drink and application thereof.
Background
The requirements of sobering up, dispelling effects of alcohol and reducing damages of drinking to human gastrointestinal, liver, cardiovascular and cerebrovascular organs and the like are urgent, and the development of effective sobering-up drugs or health-care foods has important significance and broad market prospect.
The anti-alcohol products in the market at present mainly comprise chemical synthetic medicines and traditional Chinese medicine preparations. Wherein, the chemical synthetic medicine can only promote the decomposition of alcohol, plays a temporary role in relieving, and the chemical medicine can cause metabolic burden to the liver and the kidney, so that the side effect is large. The traditional Chinese medicine preparation has a plurality of traditional Chinese medicine flavors and complex ingredients, and certain ingredients of the traditional Chinese medicine preparation may have certain bias or side effect; most of the anti-alcoholic medicines only focus on the effect of protecting liver functions, but neglect the damage of alcohol to other organs of drinkers, and cannot timely health other organs while protecting liver.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, and provides a traditional Chinese medicine composition for dispelling the effects of alcohol, a preparation method thereof, a traditional Chinese medicine preparation, a jelly drink and application thereof, wherein the used raw materials are from a medicine-food homologous catalog issued by the national health Committee of the people's republic of China, so that the traditional Chinese medicine composition for dispelling the effects of alcohol is safe and effective, and can promote in vivo ethanol decomposition through various ways, and reduce the damage of alcohol to human bodies, particularly liver, cardiovascular and cerebrovascular diseases and spleen and stomach.
In order to achieve the above purpose, the technical scheme of the invention is as follows:
A traditional Chinese medicine composition for dispelling the effects of alcohol and sobering up comprises the following components in parts by mass: 15-60 g of semen hoveniae, 10-40 g of mung bean, 10-40 g of sea buckthorn, 10-40 g of dried orange peel, 15-60 g of mulberry, 5-10 g of turmeric and 10-20 g of hawthorn.
The invention also discloses a preparation method of the traditional Chinese medicine composition for dispelling the effects of alcohol, which comprises the following steps:
Decocting semen Phaseoli Radiati, fructus Hippophae, pericarpium Citri Tangerinae, mori fructus, curcuma rhizome and fructus crataegi with water, filtering the extractive solution, and concentrating to obtain water decoction fluid extract;
Reflux-extracting semen Hoveniae with ethanol, filtering the extractive solution, recovering ethanol, and concentrating to obtain ethanol extract;
Mixing the water decoction fluid extract and the alcohol extract fluid extract to obtain the traditional Chinese medicine composition for dispelling the effects of alcohol.
The invention also discloses a traditional Chinese medicine preparation, which comprises a traditional Chinese medicine composition for dispelling the effects of alcohol and pharmaceutically acceptable auxiliary materials; the traditional Chinese medicine composition for dispelling the effects of alcohol is the traditional Chinese medicine composition for dispelling the effects of alcohol, or the traditional Chinese medicine composition for dispelling the effects of alcohol, which is prepared by the preparation method.
The invention also discloses a jelly drink, which comprises the traditional Chinese medicine composition for dispelling the effects of alcohol and food acceptable auxiliary materials; the traditional Chinese medicine composition for dispelling the effects of alcohol is the traditional Chinese medicine composition for dispelling the effects of alcohol, or the traditional Chinese medicine composition for dispelling the effects of alcohol, which is prepared by the preparation method.
The invention also discloses an application of the traditional Chinese medicine preparation and the jelly drink in preparation of products for relieving alcoholic intoxication and protecting liver and/or protecting cardiovascular and cerebrovascular and/or strengthening spleen and protecting stomach.
The embodiment of the invention has the following beneficial effects:
According to the embodiment of the invention, by combining with practical experiments, the specific composition and the proportion of the traditional Chinese medicine composition for dispelling the effects of alcohol are optimized, seven traditional Chinese medicine compositions with homology of medicine and food are used for combining and matching, and the traditional Chinese medicine composition for dispelling the effects of alcohol and protecting liver is mainly prepared from hovenia dulcis thunb, mung bean and turmeric which are extracted with high efficiency, sea buckthorn, dried orange peel and hawthorn which are used for strengthening the spleen and protecting the stomach and mulberry with the effect of protecting cardiovascular and cerebrovascular are combined in a reasonable manner, and the traditional Chinese medicine composition for dispelling the effects of alcohol and sobering up can promote in vivo ethanol decomposition through various ways, so that the damage of alcohol to human bodies, especially liver, cardiovascular and cerebrovascular diseases and spleen and stomach is relieved. Animal experiment results show that the traditional Chinese medicine composition for dispelling effects of alcohol can increase the tolerance time of mice to alcohol, can obviously shorten the drunk time of experimental mice, and has the advantages of excellent anti-effects of dispelling effects of alcohol, protecting liver, strengthening spleen and stomach and protecting cardiovascular and cerebrovascular diseases for drunk mice.
Therefore, the invention better expands the application range of the composition by deeply knowing the functions and meanings of the raw material components in the composition, has the advantages of simple preparation method, effective guarantee that the effective components in the raw materials can be fully extracted, and the anti-hangover Chinese medicinal composition can effectively avoid toxic and harmful effects of acetaldehyde on human bodies, realize the effects of preventing alcoholism, rapidly dispelling the effects of alcohol, protecting heart and cerebral vessels, strengthening spleen and stomach and protecting liver, realize the strengthening of two functions of dispelling the effects of alcohol and protecting viscera, has the advantages of less medicinal odor, low cost, convenient administration, no obvious toxic or side effect, convenient daily carrying, suitability for timely administration of anti-hangover crowds, and the like, and has wider market prospect.
Detailed Description
The invention is further illustrated below in connection with specific examples, but is not limited in any way.
The invention aims at developing a traditional Chinese medicine composition with excellent anti-alcohol effect and simultaneously examining the maintainability of the traditional Chinese medicine composition on viscera. In the research and development process, a large number of traditional Chinese medicine components are compounded, screened and verified, and the unexpected finding that compared with other formulas, the combination of hovenia dulcis thunb, mung beans, sea buckthorn, dried orange peel, mulberries, turmeric and hawthorns has good anti-alcohol effect, and the compound obtained by compounding the traditional Chinese medicine components plays a synergistic effect in the aspects of liver protection, cardiovascular and cerebrovascular protection, spleen strengthening and stomach protecting.
The following specific scheme is as follows:
The invention discloses a traditional Chinese medicine composition for dispelling the effects of alcohol and sobering up, which comprises the following components in parts by mass: 15-60 g of semen hoveniae, 10-40 g of mung bean, 10-40 g of sea buckthorn, 10-40 g of dried orange peel, 15-60 g of mulberry, 5-10 g of turmeric and 10-20 g of hawthorn.
Specifically, in the traditional Chinese medicine composition for dispelling the effects of alcohol, each component medicine taste contains active ingredients beneficial to dispelling the effects of alcohol, and after reasonable compatibility, a synergistic effect is generated, so that the traditional Chinese medicine composition for dispelling the effects of alcohol can be used for dispelling the effects of alcohol rapidly and effectively. Wherein:
semen hoveniae used in the invention has the functions of dispelling alcohol toxicity, quenching thirst, relieving restlessness, relieving vomiting and facilitating urination and defecation; can accelerate ethanol metabolism, increase ADH activity, shorten sobering time, and inhibit ethanol-induced muscle relaxation; the flavonoid has the functions of resisting oxidation, scavenging free radicals, resisting inflammation, resisting bacteria and viruses and protecting liver.
The mung beans used in the invention have the functions of reducing blood fat, reducing cholesterol, resisting allergy, resisting bacteria and tumors, enhancing appetite and protecting liver and kidney; is rich in protein, fat, carbohydrate and amino acid, can detoxify, and has high antioxidant capacity due to flavonoid being an efficient antioxidant component.
The sea buckthorn used in the invention has the functions of strengthening spleen, promoting digestion, relieving cough, eliminating phlegm, promoting blood circulation and relieving fatigue. Is used for treating spleen deficiency, anorexia, food stagnation abdominal pain, cough with excessive phlegm, chest pain, heart pain, and amenorrhea. Is rich in active ingredients and nutrient substances such as various vitamins, flavone, sterol, amino acid, trace elements and the like, and has important nutritive value.
The dried orange peel used in the invention has the functions of regulating qi, strengthening spleen, eliminating dampness and resolving phlegm. Can be used for treating abdominal distention, anorexia, vomiting and diarrhea, cough with excessive phlegm. Is rich in flavonoids, is a major active ingredient of Citrus plants in Rutaceae, has effects of promoting secretion of digestive juice, stimulating appetite, and protecting liver to a certain extent.
The mulberry used in the invention has the functions of nourishing yin, enriching blood, promoting the secretion of saliva or body fluid and moistening dryness. Treating deficiency of liver-yin and kidney-yin, dizziness, tinnitus, palpitation, insomnia, premature gray hair, thirst due to body fluid deficiency, internal heat, diabetes, constipation due to intestinal dryness, etc. Is rich in glucose, sucrose, vitamins, etc., and has high nutritive value. The mulberry contains various functional components such as resveratrol, proanthocyanidin, rutin and the like, has antioxidant pharmacological effects, can enhance the activity of alcohol dehydrogenase in liver tissues, has the effects of accelerating alcohol metabolism, preventing drunk and dispelling effects, preventing and inhibiting the occurrence and development of cardiovascular and cerebrovascular diseases, and reducing the risk of suffering from cardiovascular and cerebrovascular diseases.
The turmeric used in the invention has the effects of promoting blood circulation, removing blood stasis, promoting qi circulation, removing stagnation, and dispersing pungent and warm. Dredging channels and collaterals, and treating chest pain and distending pain caused by stagnation of liver qi and blood stasis. Curcumin has effects in improving liver cell, reducing liver inflammatory substances, removing toxic substances, and relieving hangover.
The hawthorn used in the invention has the functions of promoting qi circulation, removing blood stasis, astringing liver qi and strengthening spleen and stomach. Can be used for treating unsmooth blood circulation caused by liver qi disorder, and protecting liver.
Seven medicinal and edible traditional Chinese medicines with the effects of dispelling the effects of alcohol and relieving the effects of maintaining viscera are preferably selected and combined for compatibility, so that the traditional Chinese medicine composition for dispelling the effects of alcohol and relieving the effects of alcohol can promote the decomposition of ethanol in a body through various ways, and the damage of alcohol to a human body, particularly liver, cardiovascular and cerebrovascular diseases and spleen and stomach is relieved.
The weight ratio relation of each component of the traditional Chinese medicine composition for dispelling the effects of alcohol is further preferably limited, the dosage and the efficacy of each component of the traditional Chinese medicine composition are specifically regulated and controlled, and the synergistic compatibility effect of each component of the traditional Chinese medicine composition is better.
In a specific embodiment, the traditional Chinese medicine composition for dispelling the effects of alcohol comprises the following components in parts by mass: 15g of semen hoveniae, 10g of mung beans, 10g of sea buckthorn, 10g of dried orange peel, 15g of mulberries, 5g of turmeric and 10g of hawthorns.
In a specific embodiment, the traditional Chinese medicine composition for dispelling the effects of alcohol comprises the following components in parts by mass: 30g of semen hoveniae, 20g of mung beans, 20g of sea buckthorn, 20g of dried orange peel, 30g of mulberries, 10g of turmeric and 20g of hawthorns.
In a specific embodiment, the traditional Chinese medicine composition for dispelling the effects of alcohol comprises the following components in parts by mass: 60g of semen hoveniae, 40g of mung beans, 20g of sea buckthorn, 20g of dried orange peel, 30g of mulberries, 5g of turmeric and 10g of hawthorns.
In addition, the invention also discloses a preparation method of the traditional Chinese medicine composition for dispelling the effects of alcohol, which is characterized by comprising the following steps:
1) Decocting semen Phaseoli Radiati, fructus Hippophae, pericarpium Citri Tangerinae, mori fructus, curcuma rhizome and fructus crataegi with water, filtering the extractive solution, and concentrating to obtain water decoction fluid extract.
In one embodiment, step 1) specifically includes:
1.1 Extracting fructus Hippophae, pericarpium Citri Tangerinae, mori fructus, curcuma rhizome and fructus crataegi by decocting twice; the first water adding is decocted for 2 hours at the temperature of 100 ℃, the second water adding is decocted for 1 hour at the temperature of 100 ℃, and the mass volume ratio of the feed liquid ratio of sea buckthorn, dried orange peel, mulberry, turmeric to hawthorn in extraction is 1: (8-10), filtering the liquid after each decoction, combining the two filtrates, and concentrating to obtain the clear paste.
1.2 Decocting semen Phaseoli Radiati for 30min at 100deg.C, wherein the ratio of semen Phaseoli Radiati to semen Phaseoli Radiati is 1: filtering the decocted liquid and concentrating to obtain the clear paste.
2) Reflux-extracting semen Hoveniae with ethanol, filtering the extractive solution, recovering ethanol, and concentrating to obtain ethanol extract.
In one embodiment, step 2) specifically includes: extracting semen Hoveniae with secondary reflux; the secondary reflux extraction is carried out for 2 hours under the condition of 70-80 ℃, and the mass volume ratio of the feed liquid ratio of the hovenia dulcis thunb during the reflux is 1: (8-10), filtering the feed liquid after each reflux, combining the obtained filtrate twice, and concentrating to obtain an alcohol extract;
3) Mixing the fluid extracts obtained in the steps 1) to 2) to obtain the traditional Chinese medicine composition for dispelling the effects of alcohol.
The invention also discloses a traditional Chinese medicine preparation, which comprises a traditional Chinese medicine composition for dispelling the effects of alcohol and pharmaceutically acceptable auxiliary materials; the traditional Chinese medicine composition for dispelling the effects of alcohol is the traditional Chinese medicine composition for dispelling the effects of alcohol in any embodiment of the invention or the traditional Chinese medicine composition for dispelling the effects of alcohol prepared by the preparation method in any embodiment of the invention.
In one embodiment, the pharmaceutically acceptable adjuvant is one or more of maltodextrin, sugar powder, dextrin, starch, sucrose, lactose, mannitol, xylitol, chitosan and bifidus sugar.
In a specific embodiment, the mass ratio of the traditional Chinese medicine composition for dispelling the effects of alcohol to maltodextrin is 1: (0.1-2).
In a specific embodiment, the dosage form of the Chinese medicinal preparation comprises one or more of solid beverage, pill, powder, paste, tablet, granule and capsule. Preferably, the traditional Chinese medicine preparation is solid beverage.
The invention also discloses a preparation method of the traditional Chinese medicine preparation according to any embodiment of the invention, which comprises the following steps:
1) Mixing the traditional Chinese medicine composition for dispelling the effects of alcohol and pharmaceutically acceptable auxiliary materials, and adding 70-85% ethanol to obtain a soft material;
2) Granulating the soft material through a 20-mesh sieve to obtain wet granules;
3) Vacuum drying wet granules at 55-65deg.C for 1 hr, placing the dried granules in upper layer 10 mesh and lower layer 80 mesh double layer sieve, receiving container, horizontally sieving, collecting middle layer granule, and vacuum packaging to obtain Chinese medicinal preparation.
The invention also discloses a jelly drink, which comprises the traditional Chinese medicine composition for dispelling the effects of alcohol and food acceptable auxiliary materials; the traditional Chinese medicine composition for dispelling the effects of alcohol is the traditional Chinese medicine composition for dispelling the effects of alcohol in any embodiment of the invention or the traditional Chinese medicine composition for dispelling the effects of alcohol prepared by the preparation method in any embodiment of the invention.
In one embodiment, the food acceptable auxiliary material is one or more of water, powdered sugar, gelatin and potassium sorbate.
In a specific embodiment, the mass ratio of the traditional Chinese medicine composition for dispelling the effects of alcohol to the auxiliary materials is 1:3.
The invention also discloses a preparation method of the jelly drink according to any embodiment of the invention, which comprises the following steps:
mixing the Chinese medicinal composition for alleviating hangover with edible adjuvants, and molding to obtain jelly beverage.
Specifically, the preparation method adopts a preparation scheme of firstly extracting and then concentrating seven medicinal materials in a formula, controls parameters such as extraction, concentration and the like, fully enters the extracting solution for removing non-functional components such as wood fibers and the like in the medicinal materials, concentrates the extracting filtrate, and then is supplemented with pharmaceutically acceptable auxiliary materials or food acceptable auxiliary materials to prepare instant traditional Chinese medicine particles or jelly drinks, thereby being beneficial to the absorption of the functional components and the full play of the efficacy, and being more convenient to store, carry and use.
The invention also discloses an application of the traditional Chinese medicine preparation according to any embodiment of the invention or the jelly drink according to any embodiment of the invention in preparation of products for dispelling the effects of alcohol and protecting liver and/or protecting cardiovascular and cerebrovascular and/or strengthening spleen and protecting stomach. Specifically, the invention better expands the application range of the composition by deeply knowing the effect and meaning of each medicinal material component in the composition, so that the traditional Chinese medicine preparation and/or jelly drink not only can realize the effects of preventing drunk, rapidly dispelling the effects of alcohol and sobering up, but also has the effects of protecting heart and cerebral vessels, strengthening spleen and stomach and protecting liver, and realizes the strengthening of two functions of dispelling the effects of alcohol and sobering up and protecting viscera. In addition, the traditional Chinese medicine preparation and/or jelly drink can be used for alleviating and sobering up of drunk people, and can also be used for improving and regulating liver function and spleen and stomach function of non-drunk people.
The following are specific examples
Example 1
The traditional Chinese medicine composition for dispelling the effects of alcohol in the embodiment comprises the following components in parts by mass: 15g of semen hoveniae, 10g of mung beans, 10g of sea buckthorn, 10g of dried orange peel, 15g of mulberries, 5g of turmeric and 10g of hawthorns.
The preparation method of the traditional Chinese medicine preparation of the embodiment comprises the following steps:
1) Extracting fructus Hippophae, pericarpium Citri Tangerinae, mori fructus, curcuma rhizome and fructus crataegi with water twice; the first water adding is decocted for 2 hours at the temperature of 100 ℃, the second water adding is decocted for 1 hour at the temperature of 100 ℃, and the mass volume ratio of the feed liquid ratio of sea buckthorn, dried orange peel, mulberry, turmeric to hawthorn in the decoction is 1: (8-10), filtering the feed liquid after each decoction, combining the filtrate obtained by the two times of filtering, and concentrating to obtain clear paste;
2) Decocting semen Phaseoli Radiati with water for 30min at 100deg.C, wherein the ratio of semen Phaseoli Radiati to semen Phaseoli Radiati is 1: filtering the decocted feed liquid, and concentrating to obtain clear paste;
3) Reflux-extracting semen Hoveniae with secondary ethanol; the secondary extraction is carried out for 2 hours under the condition of 65 ℃, and the mass volume ratio of the feed liquid ratio of the hovenia dulcis thunb during the reflux is 1: (8-10), filtering the feed liquid after each reflux, combining the filtrate obtained by the two times of filtering, concentrating to obtain clear paste;
4) Mixing the water decoction fluid extract and the alcohol extract fluid extract to obtain a traditional Chinese medicine composition for dispelling the effects of alcohol;
5) The traditional Chinese medicine composition for dispelling the effects of alcohol and sobering up and maltodextrin are prepared according to the mass ratio of 1:1.5, adding ethanol with the volume fraction of 85% after mixing to prepare a soft material;
6) Granulating the soft material through a 20-mesh sieve to obtain wet granules;
7) Vacuum drying wet granules at 55-65deg.C for 1 hr, placing the dried granules in upper layer 10 mesh and lower layer 80 mesh double layer sieve, receiving container, horizontally sieving, collecting middle layer granule, and vacuum packaging to obtain Chinese medicinal preparation.
Example 2
The traditional Chinese medicine composition for dispelling the effects of alcohol in the embodiment comprises the following components in parts by mass: 30g of semen hoveniae, 20g of mung beans, 20g of sea buckthorn, 20g of dried orange peel, 30g of mulberries, 10g of turmeric and 20g of hawthorns.
The preparation method of this example is the same as that of example 1, and the preparation method of example 1 is followed to prepare the Chinese medicinal preparation of this example.
Example 3
The traditional Chinese medicine composition for dispelling the effects of alcohol in the embodiment comprises the following components in parts by mass: 60g of hovenia dulcis thunb, 40g of mung bean, 20g of sea buckthorn, 20g of dried orange peel, 30g of mulberry, 5g of turmeric and 10g of hawthorn.
The preparation method of this example is the same as that of example 1, and the preparation method of example 1 is followed to prepare the Chinese medicinal preparation of this example.
Test case
1. Experimental materials
1.1 Laboratory animals
SPF KM mice, male, 18.0 g-22.0 g in weight, supplied by the university of Shenyang medical science animal center, qualification number SCXK (Liao) 2020-0001, were fed water freely, and were fed adaptively for three days before the experiment.
1.2 Experimental herbs and reagents
The fruits of hovenia dulcis thunb, mung bean, sea buckthorn, dried orange peel, mulberry, turmeric and hawthorn used in the experiments were identified as the fruits of hovenia dulcis thunb (Hovenia acerba lindl.) of the genus Rhamnaceae, the seeds of mung bean (VIGNA RADIATA (lin.) Wilczek) of the genus vigna of the family Leguminosae, the dried ripe fruits of sea buckthorn (Hippophae rhamnoides l.) of the genus Elaeagnaceae, the dried ripe fruit peel of citrus (Citrus reticulata Blanco) of the family Rutaceae and its cultivated variety, the ripe ears of mulberry (Morus alba linn.) of the family Moraceae, the dried rhizome of turmeric (Curcuma Longa l.) of the genus Curcuma of the family Zingiberaceae and the dried ripe fruits of hawthorn (Crataegus pinnatifida bge.) of the genus Rosaceae, respectively.
Sea Wang Jinzun pieces (Shenzhen sea Wang Jiankang Co., ltd.); red star Erguotou white spirit (56%vol, beijing red star Co., ltd.).
2. Experimental part
2.1 Sobering up experiment
Healthy male mice were divided into 50 randomly into 5 groups: model group, positive control group, example 1 group, example 2 group, example 3 group, 10 each. After three days of adaptive feeding, the patients are fasted for 12 hours before the experiment, the model group is filled with gastric physiological saline according to the dosage of 10ml/kg, the positive control group is filled with gastric sea Wang Jinzun oral liquid according to the dosage of 10ml/kg, and the group of the invention is used for changing the dosage of gastric mixed solution according to the group of the invention, namely 10ml/kg of the mixed solution according to the group of the embodiment 1, the embodiment 2 and the embodiment 3. After 30min, 15ml/kg of a commercially available 56 DEG Erguotou white wine is filled. The mice were recorded for alcohol latency and alcohol time.
The drunk latency period is the time from the time of filling the stomach and the erguotous ends to the time of completely eliminating the regular reflection; the sober-up time is the time from complete disappearance of the specular reflection to complete recovery of the specular reflection. The eversion and the reflection are that the mouse keeps the supine position for more than 30s, namely the eversion and the reflection disappear, otherwise the eversion and the reflection recover.
Before the experiment, the mice are weighed and marked, and the stomach-filling administration dosage and the wine administration dosage of the mice are set in combination with the pre-experiment.
2.2 Effects of the invention on serum ethanol concentration in mice
Healthy male mice were randomized into 6 groups: blank, model, positive control, example 1, example 2, example 3, 10 per group. After the three days of adaptive feeding, the blank group and the model group are fasted without water forbidding for 12 hours before the experiment, the CMC-Na solution with the concentration of 0.5% is filled into the stomach according to the dosage of 10mL/kg, the positive control group is filled with the CMC-Na solution with the concentration of 10mL/kg (1 g/mL), the mixed gastric solution is respectively filled into the groups of examples 1-3 according to the dosage of 10mL/kg (1.5, 3.0 and 3.7g/mL according to the traditional Chinese medicine composition), after 30 minutes, the two pot heads of the stomach are filled into the groups except the normal saline of the blank group, after the two pot heads are filled into the stomach for 2 hours, the eyeballs of mice are picked up, the blood is taken into a centrifuge tube with the concentration of 1.5mL, serum is separated, and the serum is stored in a refrigerator at the temperature of minus 80 ℃ for refrigeration. The ethanol concentration in serum was determined by gas chromatography as follows:
a) Preparation of standard serum samples: taking 50 mu L of blank serum, placing the blank serum into 7 centrifuge tubes (numbered 0, 1,2,3, 4, 5 and 6), taking a blank (without ethanol) sample tube as a tube number 0, and adding 10 mu L of acetonitrile; the number 1-6 tube is a standard sample tube, and 10 mu L of series acetonitrile solution with ethanol solubility is added to prepare series standard serum samples with the ethanol concentration of 0.2, 0.5, 1,2, 4 and 10mg/mL respectively.
B) Preparation of internal standard solution: accurately weighing 1g of acetone, placing the acetone into a 100mL volumetric flask, adding acetonitrile to fix the volume, and preparing an internal standard stock solution containing 10mg/mL of acetone; precisely sucking 2mL of internal standard stock solution, placing the internal standard stock solution in a 10mL volumetric flask, and fixing the volume by acetonitrile to prepare 2mg/mL of internal standard solution.
C) Sample pretreatment: adding 10 mu L of internal standard solution into each sample tube, mixing for 1min by vortex, adding 150 mu L of acetonitrile, mixing by vortex, centrifuging for 5min at the rotating speed of 12000 r.min -1, taking supernatant into a clean centrifuge tube, adding 180 mu L of acetonitrile to dilute the supernatant, mixing by vortex for 10s, filtering by a filter membrane, and taking 1 mu L of sample.
D) Gas chromatography conditions: agilent DB-624 chromatographic column (30 m×250 μm×1.4 μm), sample inlet temperature 230 ℃, flame ionization detector (flame ionization detector, FID) temperature 250 ℃, programmed temperature, initial temperature 50 ℃, holding 5min,60 ℃/min to 220 ℃, holding 1min. Column flow 1mL/min, split sample introduction, split ratio 50:1, sample injection amount is 1 mu L.
E) Drawing a standard curve: taking a standard serum sample, operating according to a sample pretreatment method, carrying out sample injection measurement according to a gas chromatography condition, recording the peak area of ethanol and an internal standard, taking the ratio of the peak area of ethanol and the internal standard as an ordinate and the concentration of ethanol as an abscissa, drawing a standard curve, and calculating a regression equation as y= 2.0905x-0.0777 (r= 0.9988). The concentration of the serum ethanol has good linear relationship within the range of 0.2 mg/mL-10 mg/mL.
F) Determination of serum samples: taking a serum sample of an experimental mouse, adding 10 mu L of acetonitrile, operating according to a sample pretreatment method, carrying out sample injection measurement according to a gas chromatography condition, recording the peak area of ethanol and an internal standard, calculating the concentration of ethanol in the serum sample by a standard curve method according to the ratio of the peak area of ethanol to the internal standard, carrying out statistical treatment, and comparing the differences among groups.
2.4 Statistical treatment
The SPSS21.0 statistical software is adopted for analysis and treatment, and the data are all obtainedThe comparison between groups adopts single-factor analysis of variance, and the difference is significant and statistically significant as represented by P < 0.05.
3. Experimental results
3.1 Effects of the invention on the drunk latency and sober-up time of mice, and experimental results are shown in Table 1.
TABLE 1 drunk latency and sobering time for mice of each groupn＝10)
| Group of | Incubation period/min | Sobering-up time/min |
| Model group | 20.33±20.55 | 242.67±21.50 |
| Positive control group | 44.21±17.21 | 97.61±34.48** |
| Example 1 | 46.33±9.23 | 94.150±43.16 |
| Example 2 | 50.25±24.01 | 70.14±31.22** |
| Example 3 | 53.20±25.41 | 63.28±29.17** |
* : Compared to model group, P <0.05 and P <0.01
As can be seen from the results in Table 1, compared with the model group, the high, medium and low dose groups of the traditional Chinese medicine composition can remarkably shorten the drunk time (p < 0.01) of the mice with acute alcoholism and can prolong the drunk latency (p < 0.01) of the mice. The effects of the high, medium and low dose groups of the traditional Chinese medicine composition are superior to those of a sea Wang Jinzun control group in the aspects of prolonging the drunk latency period and shortening the drunk time.
3.2 Effects of the invention on ethanol concentration in mouse blood, serum ethanol concentration measurement results are shown in Table 2.
TABLE 2 serum ethanol concentration in micen＝10)
| Group of | Ethanol serum content/mg/mL |
| Blank group | 0 |
| Model group | 7.39±0.49## |
| Positive group | 7.05±0.46 |
| Example 1 | 5.17±0.82** |
| Example 2 | 4.19±0.45** |
| Example 3 | 3.69±0.56** |
#: Compared to the blank, # represents P <0.05, # represents P <0.01; * : compared to model group, P <0.05 and P <0.01
After the ethanol enters the human body, most of the ethanol is absorbed by the intestinal tract except for a small part of the ethanol is absorbed by the stomach, the ethanol is completely absorbed into the blood within 30-90 min, the drunk appearance has a direct relation with the concentration of the ethanol in the blood, and the higher the concentration of the ethanol, the more serious the drunk. Therefore, examining the concentration of ethanol in blood is an important index for evaluating the anti-hangover effect. The effect of the application on the ethanol concentration of the mouse serum is known by measuring the ethanol concentration in the mouse serum. As can be seen from the results in table 2, the ethanol concentration of the model group was significantly increased (P < 0.01) compared to the blank group, indicating that the model replication was successful. Compared with a model group, in the aspect of reducing the ethanol concentration, the high, medium and low dosage groups and the positive group of the traditional Chinese medicine composition can obviously reduce the ethanol concentration, the difference has significance (P is less than 0.01), and the effects of the high, medium and low dosage groups of the traditional Chinese medicine composition are better than those of a sea Wang Jinzun control group.
4. The weight proportion of the traditional Chinese medicine composition and the research of the modified formula of the traditional Chinese medicine composition
The test example carries out weight proportion research and addition and subtraction formula research on the traditional Chinese medicine compound. The formulation of the test drug is shown in Table 3 below.
TABLE 3 Chinese medicinal compositions with different proportions (each medicinal material expressed by mass)
| Semen Hoveniae | Mung bean | Sea buckthorn fruit | Dried orange peel | Mulberry fruit | Turmeric (turmeric) | Hawthorn fruit | |
| 1 | 15 | 10 | 10 | 10 | 15 | 5 | 10 |
| 2 | 30 | 20 | 20 | 20 | 30 | 10 | 20 |
| 3 | 60 | 40 | 20 | 20 | 30 | 5 | 10 |
| 4 | 10 | 10 | 10 | 10 | 15 | 10 | 20 |
| 5 | 15 | 10 | 10 | 10 | 10 | 5 | 10 |
| 6 | 15 | 10 | 10 | 10 | 0 | 10 | 10 |
| 7 | 15 | 0 | 10 | 10 | 15 | 10 | 10 |
| 8 | 15 | 10 | 10 | 10 | 15 | 0 | 10 |
Wherein, the formula 1-3 is the prescription of the embodiment 1-3; the weight ratio of each raw material medicine in the compound prescription is adjusted by the prescription 4 and the prescription 5; the formula 6 omits mulberries, the formula 7 omits mung beans, the formula 8 omits turmeric, and the rest of the medicinal materials and the weight ratio are the same as the formula 1. The formulations 1-8 were prepared into a traditional Chinese medicine mixture according to the method of example 1.
The experimental method is as follows: healthy male mice were randomly divided into 10 groups of 100: model group, positive control group and formula 1-8, 10 in each group. After three days of adaptive feeding, the patients are fasted for 12 hours before the experiment, the model group is irrigated with gastric physiological saline according to the dosage of 10ml/kg, the positive control group is irrigated with gastric sea Wang Jinzun solution according to the dosage of 10ml/kg, and the formula of the invention is 10ml/kg of 1-8 groups of gastric irrigation mixed solution. After 30min, 15ml/kg of a commercially available 56 DEG Erguotou white wine is filled. The mice were recorded for alcohol latency and alcohol time.
The mice were weighed and labeled prior to the experiment, and the mice were set with the stomach-lavage dose and the tank wine dose in combination with the pre-experiment, and the experimental results are shown in table 4.
TABLE 4 drunk latency and sobering time for mice of each groupn＝10)
| Group of | Incubation period/min | Sobering-up time/min |
| Model group | 22.36±20.55 | 239.57±28.50 |
| Positive control group | 44.21±17.21 | 97.61±34.48** |
| Formula 1 | 46.33±9.23 | 94.15±43.16 |
| Formulation 2 | 50.25±24.01 | 70.14±31.22** |
| Formulation 3 | 53.20±25.41 | 63.28±29.17** |
| Formulation 4 | 29.11±25.16 | 144.21±33.45 |
| Formulation 5 | 44.17±22.14 | 99.21±35.27 |
| Formulation 6 | 33.22±20.22 | 134.24±42.24 |
| Formulation 7 | 27.39±25.41 | 156.55±43.12 |
| Formulation 8 | 36.17±22.14 | 105.18±37.98 |
* : Compared to model group, P <0.05 and P <0.01
As can be seen from the results in table 3, the formula after subtracting certain medicinal flavors on the basis of the Chinese herbal compound of the present application, such as the formula 6 minus mulberries, the formula 7 minus mung beans and the formula 8 minus turmeric, although the drunk latency can be prolonged and the drunk time shortened to some extent (p < 0.05 compared with the model group), is not as effective as the original formula of the present application, in particular, unlike the formulas 1 to 3 (p is less than 0.01 compared with the model group) in the original formula. This illustrates that there may be some synergy between the various flavors of the present application. Particularly, under the weight proportion of the compositions 1-3, the traditional Chinese medicine composition has the best effect in the aspects of prolonging the drunk latency period and shortening the drunk time, and has extremely obvious difference (p is less than 0.01) compared with a model group.
In conclusion, the invention combines with practical experiments, preferably selects the specific composition and the proportion of the traditional Chinese medicine composition for dispelling the effects of alcohol, and uses seven medicinal materials with homology of medicine and food for combination and compatibility, so that the traditional Chinese medicine composition for dispelling the effects of alcohol can promote in vivo ethanol decomposition through various ways, and lighten the damage of alcohol to human bodies, in particular to liver, cardiovascular and cerebrovascular diseases and spleen and stomach. The animal experiment result shows that the traditional Chinese medicine composition for dispelling the effects of alcohol can increase the tolerance time of mice to alcohol, can obviously shorten the drunk time of experimental mice, has excellent anti-alcoholic effect on drunk mice, shows that the traditional Chinese medicine composition for dispelling the effects of alcohol can effectively avoid toxic action of acetaldehyde on human bodies, realizes the effects of preventing alcohol, rapidly dispelling the effects of alcohol, protecting heart and cerebral vessels, strengthening spleen and stomach and protecting liver, realizes the strengthening of two functions of dispelling the effects of alcohol and protecting viscera, has the advantages of less number of medicine tastes, low cost, convenient administration, no obvious toxic or side effect, convenient daily carrying, suitability for timely administration of people with the requirements of dispelling the effects of alcohol, and the like, and has extremely broad market prospect.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the claims. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (10)
1. The traditional Chinese medicine composition for dispelling the effects of alcohol is characterized by comprising the following components in parts by mass:
15-60 g of semen hoveniae, 10-40 g of mung bean, 10-40 g of sea buckthorn, 10-40 g of dried orange peel, 15-60 g of mulberry, 5-10 g of turmeric and 10-20 g of hawthorn.
2. The traditional Chinese medicine composition for dispelling the effects of alcohol according to claim 1, which is characterized by comprising the following components in mass: 15g of the hovenia dulcis thunb, 10g of the mung bean, 10g of the sea buckthorn, 10g of the dried orange peel, 15g of the mulberry, 5g of the turmeric and 10g of the hawthorn.
3. The traditional Chinese medicine composition for dispelling the effects of alcohol according to claim 1, which is characterized by comprising the following components in mass:
30g of the hovenia dulcis thunb, 20g of the mung bean, 20g of the sea buckthorn, 20g of the dried orange peel, 30g of the mulberry, 10g of the turmeric and 20g of the hawthorn.
4. The traditional Chinese medicine composition for dispelling the effects of alcohol according to claim 1, which is characterized by comprising the following components in mass:
60g of the hovenia dulcis thunb, 40g of the mung bean, 20g of the sea buckthorn, 20g of the dried orange peel, 30g of the mulberry, 5g of the turmeric and 10g of the hawthorn.
5. A method for preparing a traditional Chinese medicine composition for alleviating and sobering up according to any one of claims 1 to 4, comprising the following steps:
Decocting semen Phaseoli Radiati, fructus Hippophae, pericarpium Citri Tangerinae, mori fructus, curcuma rhizome and fructus crataegi with water, filtering the extractive solution, and concentrating to obtain water decoction fluid extract;
Reflux-extracting semen Hoveniae with ethanol, filtering the extractive solution, recovering ethanol, and concentrating to obtain ethanol extract;
Mixing the water decoction fluid extract and the alcohol extract fluid extract to obtain the traditional Chinese medicine composition for dispelling the effects of alcohol.
6. A Chinese medicinal preparation is characterized by comprising a Chinese medicinal composition for dispelling the effects of alcohol and pharmaceutically acceptable auxiliary materials; the traditional Chinese medicine composition for dispelling the effects of alcohol is prepared by the traditional Chinese medicine composition for dispelling the effects of alcohol according to any one of claims 1-4 or the preparation method according to claim 5.
7. The Chinese medicinal preparation according to claim 6, wherein the pharmaceutically acceptable auxiliary materials are one or more of maltodextrin, powdered sugar, dextrin, starch, sucrose, lactose, mannitol, xylitol, chitosan and bifidobacterium;
The mass ratio of the traditional Chinese medicine composition for dispelling the effects of alcohol to the auxiliary materials is 1: (0.1-2);
The dosage forms of the traditional Chinese medicine preparation comprise one or more than two of solid beverage, pill, powder, paste, tablet, granule and capsule;
the preparation method of the traditional Chinese medicine preparation comprises the following steps:
mixing the traditional Chinese medicine composition for dispelling the effects of alcohol and the pharmaceutically acceptable auxiliary materials, and adding 70-85% ethanol by volume fraction to obtain a soft material;
Granulating the soft material through a 20-mesh sieve to obtain wet granules;
And (3) carrying out vacuum drying on the wet particles for 1h at the temperature of 55-65 ℃, placing the dried particles in an upper layer of 10-mesh double-layer sieve with the mesh size of 80-mesh double-layer sieve being horizontal, taking the particles in the middle layer, and carrying out vacuum packaging to obtain the traditional Chinese medicine preparation.
8. A jelly drink is characterized by comprising a traditional Chinese medicine composition for dispelling the effects of alcohol and food acceptable auxiliary materials; the traditional Chinese medicine composition for dispelling the effects of alcohol is prepared by the traditional Chinese medicine composition for dispelling the effects of alcohol according to any one of claims 1-4 or the preparation method according to claim 5.
9. The jelly drink according to claim 8, wherein the food acceptable auxiliary material is one or more of water, powdered sugar, gelatin and potassium sorbate;
the mass ratio of the traditional Chinese medicine composition for dispelling the effects of alcohol to the auxiliary materials is 1:3.
10. Use of a Chinese medicinal preparation according to any one of claims 6 to 7 or a jelly drink according to any one of claims 8 to 9 for the preparation of a product for alleviating hangover and protecting liver and/or protecting cardiovascular and cerebrovascular vessels and/or strengthening spleen and stomach.
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