CN117959204A - Tri-white peptide composition and application thereof in preparation of skin care product with effects of brightening skin color and removing spots - Google Patents
Tri-white peptide composition and application thereof in preparation of skin care product with effects of brightening skin color and removing spots Download PDFInfo
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- CN117959204A CN117959204A CN202410018968.0A CN202410018968A CN117959204A CN 117959204 A CN117959204 A CN 117959204A CN 202410018968 A CN202410018968 A CN 202410018968A CN 117959204 A CN117959204 A CN 117959204A
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Abstract
The invention belongs to the technical field of cosmetics, and particularly discloses a triple-white peptide composition which comprises decarboxylated carnosine hydrochloride, hexapeptide-2 and nonapeptide-1; the mass ratio of the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1 is (2-8.7): (0.8-5): (0.5-3). According to the invention, the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1 are combined according to the specific mass ratio, so that the triple white peptide composition with excellent whitening and skin brightening effects is obtained, and the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1 interact and are matched with each other to realize synergistic interaction, so that the whitening and skin brightening effects are effectively realized based on a complex action mechanism.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a three-white peptide composition and application thereof in preparing skin care products with effects of brightening skin color and lightening spots and removing marks.
Background
Melanin is a biological pigment, which is formed by a series of chemical reactions of tyrosine or 3, 4-dihydroxybenzene alanyl, and is the same pigment for animals, plants and protozoa. Melanin is typically present in a polymeric manner. Melanin synthesis must have 3 basic substances: ① tyrosine: a main raw material for producing melanin; ② Tyrosinase: the main rate-limiting enzyme for converting tyrosine into melanin is a composition of copper and protein; ③ oxygen: tyrosine produces melanin under the action of tyrosinase, an oxidation process that must be combined with oxygen to convert it to melanin. The soluble brown-black pigment mainly originates from glycosylation, which is also called maillard reaction, which is one of the causes of skin pigmentation, due to the formation of brown-colored substances when glycine is mixed with glucose and heated.
The existing whitening and skin-brightening cosmetic has a single action mechanism, is difficult to realize the whitening and skin-brightening effect, and has the defects of external factors (ultraviolet rays and haze) and internal factors (ageing and inflammation) as well as macroscopic factors and microscopic manifestations because the formation mechanism of melanin is very complex, so that the addition of a single whitening component is difficult to effectively inhibit the melanin, and the whitening and skin-brightening effect is difficult to realize.
In view of this, the present application has been proposed.
Disclosure of Invention
The invention provides a triple white peptide composition and application thereof in preparing skin care products with skin lightening and spot lightening and mark removing effects, wherein the triple white peptide composition has excellent whitening and lightening effects.
The invention solves the technical problems by adopting the following technical scheme:
a composition (or whitening and skin-brightening composition) comprising decarboxylated carnosine hydrochloride, hexapeptide-2 and nonapeptide-1;
The mass ratio of the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1 is (2-8.7): (0.8-5): (0.5-3).
Decarboxylated carnosine hydrochloride is a dipeptide with excellent free radical scavenging, anti-glycosylation effects similar to carnosine in structure, but with stability/anti-proteolytic capacity 30 times that of carnosine, with glycation reversal functions, which can function longer. Accelerating regeneration of collagen, lightening skin dark yellow, repairing intensive care, improving brightness, and brightening new muscles.
Hexapeptide-2 is a cosmetic polypeptide containing six amino acids, can inhibit the activity of tyrosinase by reducing the level of cyclic adenosine monophosphate, so as to reduce melanin production, is an antagonist of melanin, can finally control skin color to prevent color spots from being produced and effectively lighten skin, enables skin color to become even and active, is an effective brightening oligopeptide, can inhibit the activity of beta-galactosidase and reduce the aging level of cells, and therefore, the hexapeptide-2 also has the effects of resisting aging and reducing wrinkles.
The nine peptide-1 is a small molecular whitening bionic peptide, consists of nine amino acid molecules, is an alpha-MSH antagonist, and acts on skin with high specificity, and MC1 receptors on the nine peptide-1 and melanocytes have very good matching property, so that the nine peptide-1 can be used as an antagonist for promoting melanin and cell hormones, competitively combined with the MC1 receptors, prevent tyrosinase from being further activated to generate melanin, effectively whiten and lighten skin color, the nine peptide-1 can promote collagen metabolism, release signals, remind the skin to increase collagen synthesis, inhibit muscle movement, reduce wrinkles, simultaneously, the nine peptide-1 has strong penetrability on the skin, can be combined with skin epithelial tissues through a horny layer, participate in and improve skin cell metabolism, strengthen collagen activity in the skin, keep the integrity of horny layer moisture and fiber structures, strengthen blood circulation, and provide nutrition for cells.
The three-white peptide composition consists of the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1, the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1 are creatively combined according to the specific mass ratio, so that the three-white peptide composition with excellent whitening and skin brightening effects is obtained, the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1 interact and are matched with each other, the synergy is realized, the whitening and skin brightening effects are effectively realized based on a complex action mechanism, the mass ratio of the three has higher specific matching performance, and the whitening and skin brightening effects are obviously reduced if the mass ratio of the three is changed.
As a preferred embodiment of the present invention, the mass ratio of the decarboxylated carnosine hydrochloride, hexapeptide-2, and nonapeptide-1 is (4-7): (2.2 to 4): (0.8-2). The inventor researches find that the synergistic effect is more obvious and the whitening and skin brightening effects are further improved especially under the mass ratio.
As a preferred embodiment of the present invention, the mass ratio of the decarboxylated carnosine hydrochloride, hexapeptide-2, nonapeptide-1 is 6:3:1. especially when the amount of each raw material is in the range, the whitening and skin-brightening effects are optimal.
As a preferred embodiment of the present invention, the mass of the decarboxylated carnosine hydrochloride in the triple-white peptide composition is 25-670% of the total mass of hexapeptide-2 and nonapeptide-1.
As a preferred embodiment of the present invention, the mass of the decarboxylated carnosine hydrochloride in the triple-white peptide composition is 66-240% of the total mass of hexapeptide-2 and nonapeptide-1.
The invention also provides application of the three-white peptide composition in preparing skin care products with effects of brightening skin color and lightening spots and eliminating marks.
As a preferred embodiment of the invention, the skin care product is in the form of water, emulsion, cream, gel, facial mask or essence.
As a preferred embodiment of the invention, the weight percentage of the triple white peptide composition in the skin care product is 0.01-10%.
As a preferred embodiment of the invention, the weight percentage of the triple white peptide composition in the skin care product is 0.1-5%.
As a preferred embodiment of the invention, the weight percentage of the triple white peptide composition in the skin care product is 0.2-1%.
The invention has the beneficial effects that: (1) According to the invention, the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1 are combined according to the specific mass ratio, so that the three-white peptide composition with excellent whitening and skin brightening effects is obtained, the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1 interact and are matched with each other to realize synergistic effect, the whitening and skin brightening effects are effectively realized based on a complex action mechanism, the mass ratio of the three is high, and if the mass ratio of the three is changed, the whitening and skin brightening effects are obviously reduced.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the invention, the technical characteristics described in an open mode comprise a closed technical scheme composed of the listed characteristics and also comprise an open technical scheme comprising the listed characteristics.
In the present invention, the numerical ranges are referred to as continuous, and include the minimum and maximum values of the ranges, and each value between the minimum and maximum values, unless otherwise specified. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range description features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to include any and all subranges subsumed therein.
The raw materials or instruments for the components used in each example and comparative example of the present invention were all commercially available raw materials or instruments unless otherwise specified, and the raw materials for the components used in each parallel experiment were all the same.
In the present invention, the specific dispersing and stirring treatment method is not particularly limited.
Example 1
A triple-white peptide composition, wherein the mass ratio of decarboxylated carnosine hydrochloride, hexapeptide-2 and nonapeptide-1 is 6:3:1.
The mass of decarboxylated carnosine hydrochloride in the triple-white peptide composition is 150% of the total mass of hexapeptide-2 and nonapeptide-1.
Example 2
A triple-white peptide composition, wherein the mass ratio of decarboxylated carnosine hydrochloride, hexapeptide-2 and nonapeptide-1 is 4:4:2.
The mass of decarboxylated carnosine hydrochloride in the triple-white peptide composition was 66.67% of the total mass of hexapeptide-2 and nonapeptide-1.
Example 3
A triple-white peptide composition, wherein the mass ratio of decarboxylated carnosine hydrochloride, hexapeptide-2 and nonapeptide-1 is 7:2.2:0.8.
The mass of decarboxylated carnosine hydrochloride in the triple-white peptide composition is 233.33% of the total mass of hexapeptide-2 and nonapeptide-1.
Example 4
A triple-white peptide composition, wherein the mass ratio of decarboxylated carnosine hydrochloride, hexapeptide-2 and nonapeptide-1 is 8.7:0.8:0.5.
The mass of decarboxylated carnosine hydrochloride in the triple-white peptide composition is 669.23% of the total mass of hexapeptide-2 and nonapeptide-1.
Example 5
A triple-white peptide composition, wherein the mass ratio of decarboxylated carnosine hydrochloride, hexapeptide-2 and nonapeptide-1 is 2:5:3.
The mass of decarboxylated carnosine hydrochloride in the triple-white peptide composition is 25% of the total mass of hexapeptide-2 and nonapeptide-1.
Comparative example 1
Comparative example 1 differs from example 1 in that comparative example 1 does not contain decarboxylated carnosine hydrochloride, all other things being equal.
The composition of the comparative example comprises hexapeptide-2 and nonapeptide-1, wherein the mass ratio of the hexapeptide-2 to the nonapeptide-1 is 3:1.
Comparative example 2
Comparative example 2 differs from example 1 in that comparative example 2 does not contain hexapeptide-2, all of which are identical.
The composition of the comparative example comprises decarboxylated carnosine hydrochloride and nonapeptide-1, wherein the mass ratio of the decarboxylated carnosine hydrochloride to the nonapeptide-1 is 6:1.
Comparative example 3
Comparative example 3 differs from example 1 in that comparative example 3 does not contain nonapeptide-1, all of which are identical.
The composition of the comparative example comprises decarboxylated carnosine hydrochloride and nonapeptide-1, wherein the mass ratio of the decarboxylated carnosine hydrochloride to the nonapeptide-1 is 6:3.
Comparative example 4
Comparative example 4 differs from example 1 in that comparative example 4 does not contain hexapeptide-2, nonapeptide-1, and comparative example 4 is a single decarboxylated carnosine hydrochloride.
Comparative example 5
Comparative example 5 differs from example 1 in that comparative example 5 does not contain decarboxylated carnosine hydrochloride, nonapeptide-1, and comparative example 5 is a single hexapeptide-2.
Comparative example 6
Comparative example 6 differs from example 1 in that comparative example 6 does not contain decarboxylated carnosine hydrochloride, hexapeptide-2, and comparative example 5 is a single nonapeptide-1.
Comparative example 7
Comparative example 7 is different from example 1 in that the mass ratio of each raw material is different, and the other are the same.
A triple-white peptide composition, wherein the mass ratio of decarboxylated carnosine hydrochloride, hexapeptide-2 and nonapeptide-1 is 9:0.6:0.4.
Comparative example 8
Comparative example 8 is different from example 1 in that the mass ratio of each raw material is different, and the other are the same.
A triple-white peptide composition, wherein the mass ratio of decarboxylated carnosine hydrochloride, hexapeptide-2 and nonapeptide-1 is 1:4:5.
Test case
The essence is prepared according to the following formula: 3% of butanediol, 2% of glycerol, 0.2% of hydrolyzed sclerotium rolfsii, 1% of an object to be detected and the balance of water.
Among them, the test objects are the products of examples and comparative examples.
1.65 Volunteers were selected and randomly divided into 13 groups of 5 persons each, and the examples and the prepared essence were tried out respectively.
Inclusion volunteer criteria were: women aged 20-35 years; hormonal drugs and immunosuppressants have not been used in the last month; the test site is not currently available to other clinical trials within about 30 days; can be matched with a tester well; all contents of the informed consent form can be read and understood, and the informed consent form is voluntarily signed; during the test, it was agreed that no cosmetics, drugs and health products having an influence on the results were used. Exclusion criteria: those with open wounds or erosive surfaces; highly allergic constitution; those with history of cosmetic allergy; female pregnant, lactating or intended to be pregnant during testing; has severe barycenter, liver and kidney function injury and severe hypoimmunity; patients with mental diseases and severe endocrine diseases and patients with oral contraceptives; clinical testers or other testers taking medicines within 830 days, or those who have medicines with systematic effects on test results within nearly 1 week; cosmetic products that may have an effect on the test results for oral and topical use within 2 weeks; researchers consider it unsuitable for participating in this test. Abort and exit criteria: smearing the tested sample or performing a return visit record according to the requirement in the test period; during use, suffering from serious diseases or suffering from serious adverse reactions.
After the skin of the face of a volunteer is cleaned every morning and evening, a proper amount of essence (1.8-2.2 g) is applied to the whole face by hand, no other cosmetics or medicines are applied to the face during the test period, the skin is continuously used for 4 weeks, and the change of skin melanin MI and L before and after the corresponding products are used by a CK multifunctional skin tester (Germany) is evaluated.
Melanin content change rate mi= (post-product use MI value-pre-product use MI value)/pre-product use MI value.
Luminance change rate l= (value of L after product use-value of L before product use)/value of L before product use.
TABLE 1
As can be seen from table 1, the composition of the present invention has excellent whitening effect and can effectively lighten skin color.
As can be seen from comparative examples 1 to 3, example 1 is the best mode for carrying out the present invention, and has the best whitening effect.
As can be seen from comparative examples 1 to 3 and examples 4 to 5, the mass ratio of each raw material in the composition has a certain effect on the whitening effect, and the mass ratio of each raw material is controlled as follows: (2-8.7): (0.8-5): (0.5-3), the whitening effect is further improved, and the skin color can be further lightened.
The addition amounts of the comparative examples 1-6 and the example 1 in the essence are 1%, and the effects of the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1 in the invention are synergistic in whitening and brightening skin, and unexpected effects are generated by combining the three.
As is clear from comparative examples 1 and 7 to 8, the mass ratio of the decarboxylated carnosine hydrochloride, hexapeptide-2, and nonapeptide-1 has a large influence on the effect, and the whitening and skin-brightening effects are remarkably improved by controlling the mass ratio of the decarboxylated carnosine hydrochloride, hexapeptide-2, and nonapeptide-1 within the range of the present invention, while the mass ratio of the decarboxylated carnosine hydrochloride, hexapeptide-2, and nonapeptide-1 deviates from the range of the present invention, which results in a remarkable decrease in the whitening and skin-brightening effects.
Finally, it should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the invention, and that those skilled in the art will understand that changes can be made to the technical solutions of the invention or equivalents thereof without departing from the spirit and scope of the technical solutions of the invention.
Claims (10)
1. A triple-white peptide composition comprising decarboxylated carnosine hydrochloride, hexapeptide-2 and nonapeptide-1;
The mass ratio of the decarboxylated carnosine hydrochloride, the hexapeptide-2 and the nonapeptide-1 is (2-8.7): (0.8-5): (0.5-3).
2. The triple-white peptide composition according to claim 1, wherein the mass ratio of the decarboxylated carnosine hydrochloride, hexapeptide-2, nonapeptide-1 is (4-7): (2.2 to 4): (0.8-2).
3. The triple-white peptide composition according to claim 1, wherein the mass ratio of the decarboxylated carnosine hydrochloride, hexapeptide-2, nonapeptide-1 is 6:3:1.
4. The triple-white peptide composition according to claim 1, wherein the mass of decarboxylated carnosine hydrochloride in the triple-white peptide composition is 25-670% of the total mass of hexapeptide-2 and nonapeptide-1.
5. The triple-white peptide composition according to claim 1, wherein the mass of decarboxylated carnosine hydrochloride in the triple-white peptide composition is 66-240% of the total mass of hexapeptide-2 and nonapeptide-1.
6. Use of the triple white peptide composition according to any one of claims 1 to 5 for preparing a skin care product having skin lightening and spot lightening and mark removing effects.
7. The use according to claim 6, wherein the skin care product is in the form of an aqueous solution, an emulsion, a cream, a gel, a mask or an essence.
8. The use according to claim 6, wherein the composition comprises 0.01-10% by mass of the skin care product.
9. The use according to claim 6, wherein the weight percentage of the tripeptide composition in the skin care product is 0.1-5%.
10. The use according to claim 6, wherein the weight percentage of the tripeptide composition in the skin care product is 0.2-1%.
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| CN202410018968.0A CN117959204A (en) | 2024-01-05 | 2024-01-05 | Tri-white peptide composition and application thereof in preparation of skin care product with effects of brightening skin color and removing spots |
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