CN117887572B - Quick-connection structure of artificial liver system cell reactor - Google Patents
Quick-connection structure of artificial liver system cell reactor Download PDFInfo
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- CN117887572B CN117887572B CN202311643426.4A CN202311643426A CN117887572B CN 117887572 B CN117887572 B CN 117887572B CN 202311643426 A CN202311643426 A CN 202311643426A CN 117887572 B CN117887572 B CN 117887572B
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
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- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/46—Means for fastening
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
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Abstract
The application discloses a quick-connection structure of an artificial liver system cell reactor, which is suitable for a cell reactor with connecting pipe orifices at two ends, wherein a plurality of connecting plugs are arranged on connecting plates along the arrangement direction, the connecting plugs are in plug-in fit with the connecting pipe orifices, the connecting plugs are communicated with the connecting pipe orifices, the connecting pipe orifice at one end of the cell reactor is communicated with one of the connecting plates, the other end of the cell reactor is communicated with the other connecting plate, and the two connecting plates are used for fixing a plurality of cell reactors; the communication plate is provided with a plugging unit and a plugging pipe orifice, the plugging pipe orifice is communicated with each connecting plug through a fluid channel in the connecting plate, and the plugging unit can enable the plugging pipe orifice to be switched between a plugging state and a communicating state; the artificial liver system comprises two working pipe orifices, and the plugging pipe orifices are plugged and matched with the working pipe orifices, so that the two plugging pipe orifices in the reaction unit are respectively communicated with the two working pipe orifices, and the cell reactor is connected into the artificial liver system pipeline in a modularized mode, and the installation efficiency is improved.
Description
Technical Field
The application belongs to the technical field of medical appliances, and particularly relates to a quick-connection structure of an artificial liver system cell reactor.
Background
Liver is also called a "processing plant" because it is one of the important organs of the human body and has functions of synthesis, detoxification, metabolism, secretion, bioconversion, immune defense, and the like. The liver is composed of liver cells, has abundant vascular network, is reddish brown, soft and brittle, and is easily broken by violent striking, thus causing fatal massive hemorrhage. Hepatocytes are very small and invisible to the naked eye and must be visible through a microscope. The human liver has about 25 hundred million liver cells, and 5000 liver cells constitute one liver leaflet, so the total number of liver leaflets of the human liver is about 50 ten thousand.
When severely damaged by various factors (such as viruses, alcohol, medicines and the like), a great deal of necrosis of liver cells is caused, so that liver functions are severely impaired, and a group of clinical syndrome which mainly shows coagulation mechanism disorder, jaundice, hepatic encephalopathy, ascites and the like, which is called liver failure, appears. Clinically, the traditional Chinese medicine composition takes the symptoms of extreme debilitation, appetite reduction, abdominal distension, nausea, vomiting, mental change and the like as main symptoms, and has the conditions of rapid disease progress, high treatment difficulty, high medical cost and poor overall prognosis. At present, no specific and effective treatment means exist for the clinical treatment of liver failure, and comprehensive treatment is emphasized, wherein the comprehensive treatment comprises three aspects of medical basic treatment, artificial liver support treatment and liver transplantation treatment.
According to the treatment principle, the artificial liver support treatment can be divided into physical artificial liver and biological artificial liver, the physical artificial liver utilizes the adsorption action of biological membrane and chemical substances to adsorb harmful substances in blood in external pipelines, and provides beneficial substances such as oxygen to blood through functional components such as a membrane oxygenator, the biological artificial liver purifies blood by using cells cultured in vitro as a reaction system, a hollow fiber type cell reactor is currently used as a place for cell culture, a plurality of hollow fiber tubes are filled in the cell reactor, working cells are injected into areas except the hollow fiber tubes, nutrient substance fluid is exchanged with fluid in the hollow fiber tubes through the hollow fiber tubes, thus completing the culture of the working cells, then the cell reactor is connected into an artificial liver system, and the blood is exchanged with the areas except the hollow fiber tubes through the hollow fiber tubes in the cell reactor, thus purifying the blood.
When the cell reactor is installed in an artificial liver system, two ends of the cell reactor are connected with a hose, so that the cell reactor is connected into a pipeline in the artificial liver system, but when the cell reactor is clinically used, a plurality of cell reactors are needed, when a medical worker installs the cell reactor, the cell reactor is connected into the pipeline in sequence, when the next cell reactor is installed, the cell reactor is easy to touch and touch, the finished cell reactor is shaken, the mouth of the cell reactor is easy to pollute if the operation is improper, in addition, in the liquid remained in a hollow fiber pipe in the cell reactor, the cell reactor in the artificial liver system is high in price, the acting time is limited, the beneficial substances generated by the working cells are limited, and the cell reactor containing the working cells is a disposable product.
Disclosure of Invention
In order to reduce the installation difficulty of installing the cell reactor to the artificial liver system, reduce the possibility of pollution to the orifice of the cell reactor and avoid the condition that beneficial substances in the hollow fiber tube are scattered to the outside, the application provides a quick connection structure of the cell reactor of the artificial liver system.
The quick connection structure of the artificial liver system cell reactor is suitable for the cell reactor with connecting pipe orifices at two ends, and comprises two communicating plates, wherein a plurality of connecting plugs are arranged on the communicating plates along the arrangement direction, the connecting plugs are in plug connection with the connecting pipe orifices, the connecting pipe orifices are detachably connected with plugging pieces, the connecting plugs are communicated with the connecting pipe orifices, the connecting pipe orifice at one end of the cell reactor is communicated with the connecting plug of one communicating plate, the connecting pipe orifice at the other end of the cell reactor is communicated with the connecting plug of the other communicating plate, the two communicating plates are mutually connected and are used for fixing a plurality of cell reactors, and the two communicating plates and the plurality of cell reactors form a reaction unit; the communication plate is provided with a plugging unit and a plugging pipe orifice, the plugging pipe orifice is communicated with each connecting plug through a fluid channel in the communication plate, and the plugging unit can enable the plugging pipe orifice to be switched between a plugging state and a communicating state; the artificial liver system comprises two working pipe orifices, and the plugging pipe orifices are plugged and matched with the working pipe orifices, so that the two plugging pipe orifices in the reaction unit are respectively communicated with the two working pipe orifices.
According to the application, the plurality of cell reactors and the two communicating plates are integrated to form the reaction unit, and the reaction unit is connected into the pipeline of the artificial liver system through the plugging pipe orifice and the working pipe orifice in a plugging manner, so that the plurality of cell reactors are conveniently connected into the pipeline of the artificial liver system.
In one embodiment of the application, the plugging unit comprises a plugging rod; the communication plate is provided with a plugging channel communicated with the plugging pipe orifice, and the plugging rod can do linear motion along the plugging channel; one end of the plugging rod is connected with the communication plate through the elastic piece, and the other end of the plugging rod is positioned at the plugging position under the action of the elastic piece, so that the plugging rod is positioned in the plugging pipe orifice, and the plugging pipe orifice is in a plugging state.
The cell reactor is matched with the connecting plug in a plugging manner, so that when the connecting pipe orifice at one end of the cell reactor is communicated with the plugging pipe orifice of the communicating plate, the plugging rod is positioned at the plugging position to plug the plugging pipe orifice, the communication between the outside and the cell reactor through the plugging pipe orifice is avoided, the pollution of substances in the cell reactor by external pollutants is avoided, and meanwhile, beneficial substances in the cell reactor cannot enter the outside through the connecting plug and the plugging pipe orifice, so that the loss of the beneficial substances in the cell reactor is avoided.
In one embodiment of the application, the working pipe orifice is provided with a working channel, when the working pipe orifice is in plug-in fit with the plug pipe orifice, the working pipe orifice enters the plug pipe orifice and presses the plugging rod so as to enable the plugging rod to leave the plugging position, the plug pipe orifice is communicated with the fluid channel, and the working pipe orifice is communicated with each connecting plug through the working channel, the plug pipe orifice and the fluid channel.
When the working pipe orifice is plugged with the plugging pipe orifice, the plugging rod leaves the plugging position, so that the working pipe orifice is communicated with the plugging pipe orifice, and the position of the plugging rod does not need to be manually adjusted in the process, thereby avoiding pollution of pollutants to the pipe orifice.
In one embodiment of the application, the plugging channel is arranged coaxially with the plugging nozzle, and the plugging rod can move linearly along the plugging channel into the plugging nozzle to reach the plugging position.
Through the mode that shutoff passageway and grafting mouth of pipe coaxial arrangement, the external object moves along the axis of grafting mouth of pipe and can direct drive shutoff pole along shutoff passageway motion to make grafting mouth of pipe and fluid channel intercommunication.
In one embodiment of the application, the outer diameter of the working nozzle is not greater than the inner diameter of the plugging nozzle, and the working nozzle can be inserted into the plugging nozzle; the side wall of the working pipe orifice is provided with a working channel, the end face of the working pipe orifice can be extruded with the plugging rod so that the plugging rod leaves the plugging position, and the working pipe orifice is communicated with each connecting plug through the working channel.
The plugging channel and the plugging pipe orifice are coaxially arranged, and the working pipe orifice can be inserted into the plugging pipe orifice, so that the plugging rod is directly driven by the working pipe orifice to leave the plugging position, and the plugging pipe orifice is communicated with the fluid channel.
In one embodiment of the application, the plurality of connection plugs form two groups of plug units, wherein at least two connection plugs are arranged in one group of plug units, and the connection plugs in each group of plug units form an arrangement path; the fluid channel comprises fluid channel branches, the fluid channel branches are correspondingly arranged in the communication plate along each arrangement path, and the connecting plugs in each group are communicated with the fluid channel branches; the plug pipe orifice is arranged between the two groups of plug units, and is communicated with the middle position of each fluid channel branch.
The mode that the plug pipe orifice is arranged between the two groups of plug units and is communicated with the middle position of each fluid channel branch is adopted, so that blood can uniformly enter the two groups of plug units, the working states of the cell reactors communicated with the two groups of plug units are approximately the same, the situation that the single cell reactor purifies more blood, the cell reactor cannot reach the preset working time and the blood purifying effect is influenced is avoided.
In one embodiment of the application, the orientation of the plugging nozzles is perpendicular to the axis direction of the cell reactor, the orientation of the two plugging nozzles in the reaction unit is the same, the orientation of the two working nozzles is the same, and the distance between the two plugging nozzles is equal to the distance between the two working nozzles, so that the two plugging nozzles can be plugged and matched with the two working nozzles at the same time and are communicated with the two working nozzles.
Through the direction of the inserting pipe orifice perpendicular to the axis direction of the cell reactor, the directions of the two inserting pipe orifices in the reaction unit are the same, and the directions of the two working pipe orifices are the same, the inserting pipe orifice can be directly inserted into the two working pipe orifices along the direction perpendicular to the cell reactor, so that the efficiency of installing the cell reactor in an artificial liver system pipeline is greatly improved.
In one embodiment of the application, the quick-connection structure of the artificial liver system cell reactor further comprises a fixing frame, and the two communicating plates are connected with the fixing frame.
The fixing frame limits the relative position between the two communicating plates, and can improve the connection stability of the communicating plates and the cell reactor and avoid the separation of the cell reactor from the communicating plates.
In one embodiment of the application, the communication plate is provided with a plurality of connection plugs along the arrangement direction, the fixing frame is provided with a plurality of clamping claws along the arrangement direction, the distance between every two adjacent clamping claws is equal to the distance between every two adjacent connection plugs, and the clamping claws can be clamped with the side wall of the cell reactor.
The cell reactors can be fixed to the fixing frame through the clamping jaw, and the connecting plate can be connected with the cell reactors simultaneously due to the fixed positions of the cell reactors, so that the installation efficiency of the cell reactors is improved, and meanwhile, the clamping jaw fixes the positions of the cell reactors, so that a positioning effect is provided for the installation of the cell reactors and the connecting plate.
The use method of the quick connection structure of the artificial liver system cell reactor is realized based on any one of the quick connection structures of the artificial liver system cell reactor, and is used for communicating two communicating plates, a plurality of cell reactors and a working pipe orifice in an artificial liver system, and the use method of the quick connection structure of the artificial liver system cell reactor comprises the following steps: providing an acting force to enable the cell reactor to be vertically arranged; providing an acting force to enable a communication plate to be arranged above the cell reactor, arranging a connecting plug of the communication plate downwards, removing a plugging piece for plugging an upward connecting pipe orifice, and enabling a plurality of connecting plugs to be in plug-in fit with the connecting pipe orifices of a plurality of cell reactors below; providing an acting force to turn over the combination formed by the communication plate and the cell reactors, arranging the connecting pipe orifice at the other end of the cell reactor upwards, and removing the blocking piece for blocking the upward connecting pipe orifice; providing an acting force to enable the connecting plug of the other communicating plate to be downwards arranged and to be in plug-in fit with the upward connecting pipe orifice, wherein the two communicating plates and the plurality of cell reactors form a reaction unit; in the process of connecting the cell reactor with the communication plate, the plugging unit arranged in the communication plate enables the plugging pipe orifice to be in a plugging state, and the plugging pipe orifice is plugged to be communicated with the outside; and providing an acting force to enable the two plugging pipe orifices in the reaction unit to be in plugging fit with the two working pipe orifices in the artificial liver system respectively, enabling the plugging rod in the plugging unit to leave the plugging position by the working pipe orifices, and communicating the working pipe orifices with the connecting plug through the plugging pipe orifices.
The technical scheme of the application has at least the following beneficial effects:
1. According to the application, the plurality of cell reactors and the two communicating plates are integrated to form the reaction unit, and the reaction unit is connected into the pipeline of the artificial liver system through the plugging pipe orifice and the working pipe orifice in a plugging manner, so that the plurality of cell reactors are conveniently connected into the pipeline of the artificial liver system.
2. The mode that the plug pipe orifice is arranged between the two groups of plug units and is communicated with the middle position of each fluid channel branch is adopted, so that blood can uniformly enter the two groups of plug units, the working states of the cell reactors communicated with the two groups of plug units are approximately the same, the situation that the single cell reactor purifies more blood, the cell reactor cannot reach the preset working time and the blood purifying effect is influenced is avoided.
3. The cell reactors can be fixed to the fixing frame through the clamping jaw, and the connecting plate can be connected with the cell reactors simultaneously due to the fixed positions of the cell reactors, so that the installation efficiency of the cell reactors is improved, and meanwhile, the clamping jaw fixes the positions of the cell reactors, so that a positioning effect is provided for the installation of the cell reactors and the connecting plate.
Drawings
FIG. 1 is a schematic structural view of one illustrative embodiment of a reaction unit in the present application;
FIG. 2 is a schematic view of an exemplary embodiment of the present application with the occlusion rod in an occluded position;
FIG. 3 is a schematic view of an exemplary embodiment of a pawl according to the present application;
FIG. 4 is a schematic view of an exemplary embodiment of the application when the jaws are engaged with a cell reactor;
FIG. 5 is a schematic view of an exemplary embodiment of the present application in which two communication plates are connected to a plurality of cell reactors;
FIG. 6 is a schematic diagram of an exemplary embodiment of a host housing in the present application;
FIG. 7 is a schematic view of an exemplary embodiment of a work nozzle of the present application;
FIG. 8 is a schematic structural view of an exemplary embodiment of the reaction unit of the present application when mounted to a host;
FIG. 9 is a schematic diagram of an exemplary embodiment of a connector plug of the present application;
FIG. 10 is a schematic view of an exemplary embodiment of the present application with the occlusion rod out of the occlusion position;
FIG. 11 is a schematic view of an illustrative embodiment of the present application with a communication plate coupled to a plurality of cell reactors;
FIG. 12 is a schematic view of an illustrative embodiment of the present application with a communication plate inverted with respect to a plurality of cell reactors;
FIG. 13 is a schematic view of an exemplary embodiment of the present application when another communication plate is connected to a plurality of cell reactors.
In the figure:
101. a communication plate; 102. a connection plug; 103. plugging a pipe orifice; 104. a fluid channel; 105. a fluid channel branch;
201. a cell reactor; 202. a connecting pipe orifice; 203. a blocking member;
301. A fixing frame; 302. a claw;
401. A main body case;
501. A working pipe orifice;
601. A plugging rod; 602. plugging the channel; 603. and (3) a spring.
Detailed Description
For a clearer understanding of the technical features, objects and effects of the present application, embodiments of the present application will now be described with reference to the drawings, in which like reference numerals refer to identical or structurally similar but functionally identical components throughout the separate views.
In this document, "schematic" means "serving as an example, instance, or illustration," and any illustrations, embodiments described herein as "schematic" should not be construed as a more preferred or advantageous solution.
For the sake of simplicity of the drawing, the parts relevant to the present application are shown only schematically in the figures, which do not represent the actual structure thereof as a product. In addition, for simplicity and ease of understanding, components having the same structure or function in some of the figures are shown schematically only one of them, or only one of them is labeled.
Please refer to fig. 1 to 13 for an understanding of the present application.
Referring to fig. 1, a quick-connection structure of an artificial liver system cell reactor is suitable for a cell reactor 201 with connecting nozzles 202 at two ends, wherein the connecting nozzles 202 are provided with plugging pieces 203, which comprise two communicating plates 101.
Referring to fig. 1, a plurality of connection plugs 102 are arranged on a communication plate 101 along an arrangement direction, the connection plugs 102 are in plug-in fit with connection pipe orifices 202, the connection plugs 102 are communicated with the connection pipe orifices 202, one ends of a plurality of cell reactors 201 can be arranged on the communication plate 101 through the matching of the connection pipe orifices 202 and the connection plugs 102, when the cell reactors 201 are arranged vertically, one communication plate 101 is arranged above the plurality of cell reactors 201, a plugging piece 203 of the upwardly arranged connection pipe orifices 202 is removed, the plugging piece 203 can be a plug, referring to fig. 11, the connection plugs 102 of the communication plate 101 are downwardly arranged and are in plug-in fit with the connection pipe orifices 202 of the plurality of cell reactors 201 below, so that the plurality of cell reactors 201 are arranged on the communication plate 101, then the combination of the plurality of cell reactors 201 and the communication plate 101 is turned over, the other ends of the cell reactors 201 are turned over to the upper side, and the plugging piece 203 of the upwardly arranged connection pipe orifices 202 is removed; the other communicating plate 101 is then inserted and matched with the connecting pipe orifices 202 of the plurality of cell reactors 201 below, so that the connecting pipe orifice 202 at one end of the cell reactor 201 is communicated with the connecting plug 102 of one communicating plate 101, the connecting pipe orifice 202 at the other end is communicated with the connecting plug 102 of the other communicating plate 101, the two communicating plates 101 are connected and fix the plurality of cell reactors 201, and the two communicating plates 101 and the plurality of cell reactors 201 form a reaction unit.
In this process, the plugging member 203 provided on the connecting nozzle 202 can avoid the situation that the beneficial substances are lost through the downward connecting nozzle 202 when the connecting nozzle 202 is downward, and the beneficial substances in the cell reactor 201 cannot enter the outside through the upward connecting nozzle 202 under the action of gravity because the connecting nozzle 202 communicated with the outside of the cell reactor 201 is always upward, so that the beneficial substances in the cell reactor 201 are prevented from being lost in the process of installing the cell reactor 201 in the artificial liver system.
Referring to fig. 2, the communication plate 101 is further provided with a plugging unit and a plugging nozzle 103, the plugging unit can switch the plugging nozzle 103 between a plugging state and a communication state, and the plugging nozzle 103 is communicated with each connection plug 102 through a fluid channel 104 in the communication plate; when a plurality of cell reactors 201 are connected with two communication plates 101, the plugging unit enables the plugging pipe orifice 103 to be in a plugging state, so that the condition that beneficial substances in the cell reactors 201 enter the outside through the connecting pipe orifice 202, the connecting plug 102 and the plugging pipe orifice 103 after the cell reactors 201 are communicated with the communication plates 101 is avoided.
Referring to fig. 2, in one embodiment of the present application, the blocking unit includes a blocking rod 601, the communication plate 101 is provided with a blocking channel 602 communicating with the plugging nozzle 103, and the blocking rod 601 can move linearly along the blocking channel 602; one end of the plugging rod 601 is connected with the communication plate 101 through an elastic piece, the other end of the plugging rod is located at a plugging position under the action of the elastic piece, so that the plugging rod 601 enters the plugging pipe orifice 103 to plug the plugging pipe orifice 103, the plugging pipe orifice 103 is in a plugging state, the plugging channel 602 and the plugging pipe orifice 103 are coaxially arranged, the plugging rod 601 moves linearly along the plugging channel 602 under the action of the elastic piece to enter the plugging pipe orifice 103 so as to reach the plugging position, the plugging rod 601 enables the plugging pipe orifice 103 to be in the plugging state, and the elastic piece can be elastic components such as a spring 603 and elastic rubber.
Referring to fig. 1,3 to 5, in one embodiment of the present application, the quick-connection structure of the artificial liver system cell reactor further includes a fixing frame 301, two communication plates 101 are connected to the fixing frame 301, and the two communication plates 101 are connected to each other through the fixing frame 301, so that the two communication plates 101 and the plurality of cell reactors 201 are mounted on the fixing frame 301, thereby ensuring the stability of connection between the two communication plates 101 and the plurality of cell reactors 201, avoiding separation of the plurality of cell reactors 201 from the communication plates 101, and the fixing frame 301 ensures that the communication plates 101 are always connected to the plurality of cell reactors 201.
Further, the communication plate 101 is provided with a plurality of connection plugs 102 along the array direction, the fixing frame 301 is provided with a plurality of claws 302 along the array direction, the distance between adjacent claws 302 is equal to the distance between adjacent connection plugs 102, and the claws 302 can be clamped with the side wall of the cell reactor 201. When the cell reactor is used, the cell reactors 201 can be firstly installed with the clamping claws 302, as the distance between the clamping claws 302 is equal to the distance between the connecting plugs 102, after the cell reactors 201 are fixed on the fixing frame 301 through the clamping claws 302, one ends of the cell reactors 201 can be upwards arranged at the same time, the blocking piece 203 at the connecting pipe orifice 202 is removed, the connecting plugs 102 of the communicating plate 101 are in plug-in fit with the connecting pipe orifice 202, so that the communicating plate 101 can be simultaneously communicated with the cell reactors 201, then the communicating plate 101 can be turned to the lower parts of the cell reactors 201 by using the fixing frame 301, and then the other communicating plate 101 is simultaneously communicated with the connecting pipe orifice 202 at the other ends of the cell reactors 201. The clamping jaw 302 is clamped with the cell reactors 201, so that scattering of a plurality of cell reactors 201 in the overturning process can be effectively avoided, and the overturning difficulty is reduced; at the same time, the claws 302 provide a positioning effect for the connection of the plurality of cell reactors 201 to the communication plate 101.
As can be appreciated by those skilled in the art, the fixing frame 301 in the present application is connected to two communication plates 101, which may be that one of the communication plates 101 is fixedly connected to the fixing frame 301, the other communication plate 101 is detachably connected to the fixing frame 301, or that both of the communication plates 101 are detachably connected to the fixing frame 301; the implementation manner of the detachable connection between the communication board 101 and the fixing frame 301 is various, for example, a pressing buckle structure is arranged between the fixing frame 301 and the communication board 101, the fixing frame 301 is provided with a buckle seat, the communication board 101 is provided with a buckle head, after the connecting pipe orifice 202 is in plug-in fit with the connecting plug 102, the buckle head is positioned at the buckle seat, then the buckle head is pressed into the buckle seat to realize the fixed connection between the communication board 101 and the fixing frame 301, of course, other ways are also provided to realize the connection between the communication board 101 and the fixing frame 301, for example, the fixing frame 301 is provided with a guide rail, one communication board 101 is in sliding fit with the guide rail, so that the distance between the communication board 101 and the connecting pipe orifice 202 is adjusted, after the connecting pipe orifice 202 is in plug-in fit with the connecting plug 102, the fixed pin is used to connect the communication board 101 and the guide rail, so that the relative positions of the communication board 101 and the guide rail are fixed, and the connection between the communication board 101 and the fixing frame 301 is realized; or the fixing frame 301 and the communicating plate 101 are provided with screw holes, and the fixing frame 301 and the communicating plate 101 are fixedly connected by bolts, and of course, other modes are also provided to realize the connection of the communicating plate 101 and the fixing frame 301, which is not described herein.
Of course, the cell reactor 201 can be directly fixedly connected with the communication plate 101, the two communication plates 101 are mutually connected through the cell reactor 201, the fixing frame 301 is not arranged to limit the positions of the two communication plates 101, the communication plate 101 is provided with a buckle structure, and when the connecting plug 102 is in plug-in fit with the connecting pipe orifice 202, the buckle arranged on the communication plate 101 can be clamped with the expansion parts at the two ends of the cell reactor 201, so that the cell reactor 201 is fixedly connected with the communication plate 101, and the details are not repeated here.
Referring to fig. 6 to 8, the artificial liver system further comprises two working nozzles 501, the insertion nozzle 103 is in insertion fit with the working nozzle 501, in one embodiment of the present application, the outer diameter of the working nozzle 501 is not greater than the inner diameter of the insertion nozzle 103, the working nozzle 501 can be inserted into the insertion nozzle 103 along the axial direction of the insertion nozzle 103, so that the working nozzle 501 can squeeze the plugging rod 601 in the insertion nozzle 103, see fig. 2 and 10, while the plugging channel 602 is coaxially arranged with the insertion nozzle 103, when the working nozzle 501 moves along the axial direction of the insertion nozzle 103, the end surface of the working nozzle 501 squeezes the plugging rod 601 along the insertion nozzle 103 into the plugging channel 602, so that the plugging rod 601 leaves the plugging position, the insertion nozzle 103 communicates with the fluid channel 104, and the insertion nozzle 103 communicates with the working nozzle 501, the working channel arranged on the side wall of the working pipe orifice 501 stretches into the fluid channel 104, the working channel arranged on the side wall of the working pipe orifice 501 is communicated with each connecting plug 102 through the working channel, the inserting pipe orifice 103 and the fluid channel 104, so that the two inserting pipe orifices 103 in the reaction unit are respectively communicated with the two working pipe orifices 501, the inserting pipe orifices 103 are in a communicating state by the plugging unit, the reaction unit is communicated with a pipeline of an artificial liver system, blood can enter the plurality of cell reactors 201 through the connecting plugs 102 of one working pipe orifice 501, the inserting pipe orifice 103 and the fluid channel 104, and leaves the plurality of cell reactors 201 through the connecting plugs 102, the inserting pipe orifices 103 and the other working pipe orifice 501 arranged on the other communicating plate 101, and therefore working cells in the cell reactors 201 can purify the blood and add beneficial substances into the blood.
Of course, it can be understood by those skilled in the art that the plugging channel 602 in the present application is not limited to the manner in which the plugging channel 602 and the plugging nozzle 103 are coaxially disposed, but the plugging channel 602 may be perpendicular to the plugging nozzle 103, where the plugging channel 602 communicates with a side wall of the plugging nozzle 103, so that the plugging rod 601 can make a linear motion along a direction perpendicular to the plugging nozzle 103, and the plugging rod 601 enters the plugging nozzle 103 under the action of the elastic member, so as to plug the plugging nozzle 103, the plugging nozzle 103 is in a plugging state, and when the working nozzle 501 is inserted into the plugging nozzle 103, the shape of the working nozzle 501 matches the shape of the plugging rod 601, such as the end face of the working nozzle 501 is obliquely disposed with respect to the axis of the working nozzle 501, and the end of the plugging rod 601 is hemispherical, so that as the working nozzle 501 is inserted into the plugging nozzle 103, the working nozzle 501 squeezes the plugging rod 601, so that the plugging rod 601 leaves the internal channel of the plugging nozzle 103, and the working channel disposed at the end of the working nozzle 501 communicates with the fluid channel 104, so as to realize the communication between the working channel 103 and the fluid connection plug 102 and the respective plug 102.
It can be understood by those skilled in the art that the outer diameter of the working pipe orifice 501 can be larger than the inner diameter of the plugging pipe orifice 103, but an extrusion rod for pushing the plugging rod 601 away from the plugging position needs to be arranged in the working pipe orifice 501, the outer diameter of the extrusion rod is smaller than the inner diameter of the working pipe orifice 501, the working pipe orifice 501 is prevented from being plugged by the extrusion rod, when the working pipe orifice 501 is sleeved on the plugging pipe orifice 103, the extrusion rod stretches into the plugging pipe orifice 103 to push the plugging rod 601 away from the plugging position, and thus the working pipe orifice 501 is communicated with the plugging pipe orifice 103 and the fluid channel 104.
The plugging unit is not limited to the implementation mode of the plugging rod 601, the plugging unit can also be a valve communicated with the plugging pipe orifice 103, the plugging pipe orifice 103 is controlled by the valve to switch the plugging state and the communication state, but the plugging pipe orifice 103 is plugged by the valve, the possibility of polluting the plugging pipe orifice 103 when an operator operates the valve exists, and therefore the plugging rod 601 plugs the plugging pipe orifice 103 is a preferable scheme.
Referring to fig. 1, 6 and 8, in one embodiment of the present application, the plugging nozzles 103 are oriented perpendicular to the axial direction of the cell reactor 201, the two plugging nozzles 103 in the reaction unit are oriented the same, the two working nozzles 501 are oriented the same, and the distance between the two plugging nozzles 103 is equal to the distance between the two working nozzles 501, the two working nozzles 501 can be fixedly connected with the host housing 401 of the artificial liver system, the positions of the two working nozzles 501 are fixed, the two plugging nozzles 103 can be simultaneously communicated with the two working nozzles 501, so that the reaction unit is fixed, the modularized installation greatly accelerates the speed of installing a plurality of cell reactors 201 into the artificial liver system pipeline, and simultaneously avoids the loss of beneficial substances in the cell reactors 201, and reduces the possibility of pollution of the cell reactors 201.
Referring to fig. 1, 2 and 10, in one embodiment of the present application, a plurality of connection plugs 102 form two sets of plug units, and at least two connection plugs 102 are provided in one set of plug units, and the connection plugs 102 in each set of plug units form an arrangement path; the communication plate 101 is provided with fluid channel branches 105 corresponding to the arrangement paths, and the connection plugs 102 in each group are communicated with the fluid channel branches 105; the plug nozzle 103 is provided between the two sets of plug units, and the plug nozzle 103 communicates with the intermediate position of each fluid passage branch 105.
Referring to fig. 1, fig. 2, fig. 9 and fig. 10, the arrangement direction is a straight line direction, the communication plate 101 is provided with four connection plugs 102 along the arrangement direction array, two connection plugs 102 are in a group, two connection plugs 102 form an arrangement path, a fluid channel branch 105 is arranged in the communication plate 101 along the arrangement path, the two fluid channel branches 105 are arranged in a mirror image mode, the plugging pipe orifice 103 is arranged between the two fluid channels 104 and is communicated with the middle position of the fluid channel branch 105, so that when blood enters the fluid channel 104 through the plugging pipe orifice 103, the blood can be uniformly dispersed into each cell reactor 201, the working intensity of each cell reactor 201 is approximately the same, the situation that the working intensity of a single cell reactor 201 is high, the working effect is reduced, the purifying effect on blood is influenced is avoided, and meanwhile, the four cell reactors 201 are in a parallel connection relationship, and the purifying effect of the cell reactors 201 on the blood is ensured.
Those skilled in the art will understand that the arrangement direction in the present application is not limited to a straight line direction, but may be a curve, such as a semicircle, and will not be described herein.
Referring to fig. 5 and 11 to 13, a method for using a quick-connection structure of a cell reactor of an artificial liver system for connecting two connecting plates 101 and a plurality of cell reactors 201 with a working nozzle 501 in the artificial liver system includes: providing a force to vertically position the cell reactor 201; providing a force to enable one communication plate 101 to be arranged above the cell reactor 201, arranging the connecting plugs 102 of the communication plate 101 downwards, removing the plugging pieces 203 of the upward connecting pipe orifices 202, and enabling the plurality of connecting plugs 102 to be in plug-in fit with the connecting pipe orifices 202 of the plurality of cell reactors 201 below; providing a force to turn over the combination of the communication plate 101 and the cell reactors 201, arranging the connecting pipe orifice 202 at the other end of the cell reactor 201 upwards, and removing the plugging piece 203 of the connecting pipe orifice 202 upwards; providing a force to enable the connecting plug 102 of the other communicating plate 101 to be downwards arranged and to be in plug-in fit with the upwards connecting pipe orifice 202, wherein the two communicating plates 101 and the plurality of cell reactors 201 form a reaction unit; in the process of connecting the cell reactor with the communication plate, the plugging unit arranged in the communication plate 101 enables the plugging pipe orifice 103 to be in a plugging state, and the plugging pipe orifice 103 is plugged to be communicated with the outside; and providing an acting force to enable the two plugging pipe orifices in the reaction unit to be in plugging fit with the two working pipe orifices in the artificial liver system respectively, enabling the plugging rod in the plugging unit to leave the plugging position by the working pipe orifices, and communicating the working pipe orifices with the connecting plug through the plugging pipe orifices.
Those skilled in the art will appreciate that the diameter of the connecting pipe orifice 202 may be larger than the diameter of the connecting plug 102 or smaller than the diameter of the connecting plug 102, so that the connecting pipe orifice 202 and the connecting plug 102 can be in plug-in fit, and the connecting pipe orifice 202 can be communicated with the connecting plug 102 and can ensure the tightness of the pipeline.
The application can be used after the culture in the cell reactor is completed, a plurality of cell reactors and the communicating plates are assembled into a reaction unit, and then the assembled reaction unit is transported to an operating room, so that the possibility of pollution to the connecting pipe orifice of the cell reactor in the transportation process is reduced, and meanwhile, the modularized reaction unit is conveniently connected into an artificial liver system pipeline by medical staff, the installation difficulty is reduced, and the possibility of pollution to the cell reactor in the installation process is reduced.
Those skilled in the art will appreciate that the communication plate can be filled with a nutrient solution or other working fluid to exclude air from the communication plate.
It should be understood that although the present disclosure has been described in terms of various embodiments, not every embodiment is intended to include only a single embodiment, and such description is for clarity only, and those skilled in the art will recognize that the embodiments described herein may be suitably combined to form other embodiments as would be understood by those skilled in the art.
The above list of detailed descriptions is only specific to practical examples of the present application, and they are not intended to limit the scope of the present application, and all equivalent embodiments or modifications, such as combinations, divisions or repetitions of features, without departing from the technical spirit of the present application are included in the scope of the present application.
Claims (8)
1. The quick-connection structure of the artificial liver system cell reactor is suitable for the cell reactor with connecting pipe orifices at two ends, and is characterized by comprising two communicating plates,
The connecting pipe opening at one end of the cell reactor is communicated with the connecting plug of one of the communicating plates, the connecting pipe opening at the other end of the cell reactor is communicated with the connecting plug of the other communicating plate, the two communicating plates are mutually connected and are used for fixing a plurality of cell reactors, and the two communicating plates and the plurality of cell reactors form a reaction unit;
the communication plate is provided with a plugging unit and a plugging pipe orifice, the plugging pipe orifice is communicated with each connecting plug through a fluid channel in the communication plate, and the plugging unit can enable the plugging pipe orifice to be switched between a plugging state and a communicating state;
The artificial liver system comprises two working pipe orifices, wherein the plug pipe orifices are in plug fit with the working pipe orifices, so that the two plug pipe orifices in the reaction unit are respectively communicated with the two working pipe orifices;
The plugging unit comprises a plugging rod;
The communication plate is provided with a plugging channel communicated with the plugging pipe orifice, and the plugging rod can do linear motion along the plugging channel; one end of the plugging rod is connected with the communication plate through an elastic piece, and the other end of the plugging rod is positioned at a plugging position under the action of the elastic piece, so that the plugging rod is positioned in the plugging pipe orifice, and the plugging pipe orifice is in a plugging state;
The working pipe orifice is provided with a working channel, when the working pipe orifice is in plug-in fit with the plug-in pipe orifice, the working pipe orifice enters the plug-in pipe orifice and extrudes the plugging rod so that the plugging rod is separated from the plugging position, the plug-in pipe orifice is communicated with the fluid channel, and the working pipe orifice is communicated with each connecting plug through the working channel, the plug-in pipe orifice and the fluid channel.
2. The rapid connection structure of an artificial liver system cell reactor according to claim 1, wherein,
The plugging channel and the plugging pipe orifice are coaxially arranged, and the plugging rod can linearly move along the plugging channel to enter the plugging pipe orifice so as to reach a plugging position.
3. The rapid connection structure of an artificial liver system cell reactor according to claim 2, wherein,
The outer diameter of the working pipe orifice is not larger than the inner diameter of the inserting pipe orifice, and the working pipe orifice can be inserted into the inserting pipe orifice;
The side wall of the working pipe orifice is provided with the working channel, the end face of the working pipe orifice can be extruded with the plugging rod, so that the plugging rod is separated from the plugging position, and the working pipe orifice is communicated with each connecting plug through the working channel.
4. The rapid connection structure of an artificial liver system cell reactor according to claim 1, wherein,
The plurality of connecting plugs form two groups of plug units, at least two connecting plugs are arranged in one group of plug units, and the connecting plugs in each group of plug units form an arrangement path;
The fluid channel comprises fluid channel branches, the fluid channel branches are correspondingly arranged in the communication plate along each arrangement path, and the connecting plugs in each group are communicated with the fluid channel branches;
The plug pipe orifices are arranged between the two groups of plug units, and are communicated with the middle positions of the branches of the fluid channels.
5. The rapid connection structure of an artificial liver system cell reactor according to claim 1, wherein,
The direction of the plugging pipe orifice is perpendicular to the axis direction of the cell reactor, the directions of the two plugging pipe orifices in the reaction unit are the same, the directions of the two working pipe orifices are the same, and the distance between the two plugging pipe orifices is equal to the distance between the two working pipe orifices, so that the two plugging pipe orifices can be simultaneously plugged and matched with the two working pipe orifices and are communicated with the two working pipe orifices.
6. The rapid connection structure of an artificial liver system cell reactor according to claim 1, wherein,
The quick-connection structure of the artificial liver system cell reactor further comprises a fixing frame, and the two communicating plates are connected with the fixing frame.
7. The rapid connection structure of artificial liver system cell reactor according to claim 6, wherein,
The communication board is equipped with a plurality of connecting plugs along the array of array direction, the mount is followed array direction array is equipped with a plurality of jack catchs, and is adjacent the distance between the jack catchs equals adjacent the distance between the connecting plug, the jack catchs can with cell reactor lateral wall joint.
8. A method for using a quick-connection structure of an artificial liver system cell reactor, which is realized based on the quick-connection structure of an artificial liver system cell reactor according to any one of claims 1 to 7, and is used for communicating two communicating plates, a plurality of cell reactors and a working pipe orifice in an artificial liver system, wherein the method for using the quick-connection structure of the artificial liver system cell reactor comprises the following steps:
Providing an acting force to enable the cell reactor to be vertically arranged;
Providing an acting force to enable a communication plate to be arranged above the cell reactor, arranging a connecting plug of the communication plate downwards, removing a plugging piece for plugging an upward connecting pipe orifice, and enabling a plurality of connecting plugs to be in plug-in fit with the connecting pipe orifices of a plurality of cell reactors below;
Providing an acting force to turn over the combination formed by the communication plate and the cell reactors, arranging the connecting pipe orifice at the other end of the cell reactor upwards, and removing the blocking piece for blocking the upward connecting pipe orifice;
Providing an acting force to enable the connecting plug of the other communicating plate to be downwards arranged and to be in plug-in fit with the upward connecting pipe orifice, wherein the two communicating plates and the plurality of cell reactors form a reaction unit;
In the process of connecting the cell reactor with the communication plate, the plugging unit arranged in the communication plate enables the plugging pipe orifice to be in a plugging state, and the plugging pipe orifice is plugged to be communicated with the outside;
And providing an acting force to enable the two plugging pipe orifices in the reaction unit to be in plugging fit with the two working pipe orifices in the artificial liver system respectively, enabling the plugging rod in the plugging unit to leave the plugging position by the working pipe orifices, and communicating the working pipe orifices with the connecting plug through the plugging pipe orifices.
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| CN218063895U (en) * | 2022-05-19 | 2022-12-16 | 杭州毅而玛管业有限公司 | PE pipe with quick-connection plug |
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| CN101732771B (en) * | 2009-12-17 | 2011-08-17 | 中日友好医院 | Cell reactor and artificial liver support system comprising same |
| CN102114275B (en) * | 2011-03-17 | 2012-10-17 | 浙江大学 | Hepatic lobule-like bioreactor |
| CN104147652B (en) * | 2014-08-01 | 2017-04-12 | 武汉仝干医疗科技股份有限公司 | Bio-artificial liver system |
| CN104225698B (en) * | 2014-09-03 | 2016-04-13 | 西安交通大学 | A kind of hepatocyte microsphere circulating biological artificial liver support system |
| CN208632526U (en) * | 2018-07-24 | 2019-03-22 | 苏州迪欧益生物科技有限公司 | The quick connector of bioreactor culture |
| JPWO2022009672A1 (en) * | 2020-07-07 | 2022-01-13 | ||
| CN113005035A (en) * | 2021-03-26 | 2021-06-22 | 中国海洋大学 | Multichannel uniform tensile stress in-vitro cell culture device and working method |
| CN114703062B (en) * | 2022-04-29 | 2023-04-11 | 山东壹瑞特生物科技有限公司 | System for carry out adherent cell culture on a large scale |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN218063895U (en) * | 2022-05-19 | 2022-12-16 | 杭州毅而玛管业有限公司 | PE pipe with quick-connection plug |
| CN116948797A (en) * | 2023-08-03 | 2023-10-27 | 山东民和生物科技股份有限公司 | Integrated bioreactor suitable for biogas slurry and wastewater treatment |
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