CN117883541A - Traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea, which relates to the technical field of traditional Chinese medicine preparation, and comprises the following raw materials in parts by weight: 8-15 parts of rhizoma corydalis, 6-10 parts of prepared aconite, 10-15 parts of mugwort leaf, 8-12 parts of prepared ginger, 6-10 parts of pollen typhae, 20-30 parts of motherwort, 10-15 parts of medicinal cyathula root, 2-3 parts of leech and 6-8 parts of honey-fried licorice root. The traditional Chinese medicine composition disclosed by the invention has a good treatment effect on cold coagulation stasis type dysmenorrhea, is high in cure rate, definite in curative effect, not easy to relapse, good in safety and free of adverse reaction.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea.
Background
Dysmenorrhea (dysmenorrheal) is one of the common gynecological symptoms, which refers to pain and distention of the lower abdomen of women before and after menstruation or during menstrual period, accompanied by soreness of the waist or other discomfort. Symptoms such as pale complexion, nausea, vomiting, cold sweat and the like can appear in severe pain patients, and the normal life and work of patients are seriously affected.
The western medicine treatment of dysmenorrhea usually gives oral analgesics, contraceptives and surgical treatment, and the analgesics and the contraceptives only belong to symptomatic treatment, cannot cure the disease, and are not easy to be accepted by patients.
In cases of severe dysmenorrhea, excessive syndromes and deficient syndromes are more frequent, especially cold and blood stasis syndromes. The cold dysmenorrhea is caused by the constitution factor, and the deficiency of spleen and kidney of the patient's body is combined with the preference for cold and cool food, and the cold evil is cohesive in the long term, and the cold coagulates and stasis, blocks the thoroughfare and conception vessels, and causes pain in uterus. The traditional Chinese medicine treatment is to assist yang qi of spleen and kidney, warm channel, dispel cold, remove blood stasis and relieve pain. Compared with western medicine treatment, the oral traditional Chinese medicine has definite curative effect, and has the advantages of high cure rate, difficult recurrence, less adverse reaction and good patient compliance.
Disclosure of Invention
Aiming at the problems, the invention provides a traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea, which is named as a meridian warming and activating pain relieving prescription, and can effectively treat cold coagulation stasis type dysmenorrhea and relieve discomfort of patients.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
the invention provides a traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea, which is prepared from the following raw materials in parts by weight: 8-15 parts of rhizoma corydalis, 6-10 parts of prepared aconite, 10-15 parts of mugwort leaf, 8-12 parts of prepared ginger, 6-10 parts of pollen typhae, 20-30 parts of motherwort, 10-15 parts of medicinal cyathula root, 2-3 parts of leech and 6-8 parts of honey-fried licorice root.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12 parts of rhizoma corydalis, 8 parts of prepared aconite root, 12 parts of mugwort leaf, 10 parts of prepared ginger, 8 parts of cattail pollen, 30 parts of motherwort, 12 parts of medicinal cyathula root, 3 parts of leech and 6 parts of honey-fried licorice root.
Preferably, the traditional Chinese medicine composition is prepared by the following preparation method:
s1: taking rhizoma corydalis, prepared aconite root, mugwort leaf, prepared ginger, cattail pollen, motherwort, medicinal cyathula root, leech and honey-fried licorice root according to parts by weight for standby;
s2: decocting radix Aconiti lateralis Preparata with boiled water, adding water into the rest materials, decocting, filtering, decocting the residue with water, filtering, and mixing the filtrates for 2 times to obtain decoction; concentrating the decoction under reduced pressure to obtain extract;
s3: mixing the extract with pharmaceutically acceptable medicinal adjuvants, and making into the Chinese medicinal composition.
More preferably, in the step S2, the mass ratio of the radix aconiti carmichaeli preparata to the boiled water is 1:20, and the decocting time is 1h; the mass ratio of the residual raw material medicines to water is 1:10, and the decocting time is 30min; the mass ratio of the filter residue to the water is 1:6, and the decoction time is 20min.
More preferably, in the step S2, the temperature of reduced pressure evaporation is 50-55 ℃, and the relative density of the extract is 1.25-1.30.
More preferably, in the step S3, the dosage form of the traditional Chinese medicine composition is a clinically acceptable oral preparation, preferably a tablet, a capsule, a pill, a granule, a powder or a decoction.
The pharmacology of the invention: the processed aconite root enters kidney meridian, is good at tonifying kidney yang, dispelling cold and relieving pain, and the processed ginger enters spleen meridian, warms and stops pain, and two herbs are mutually used to play a role of monarch drug in dispelling cold and relieving pain together; the mugwort leaf warms channels, dissipates cold and relieves pain, the rhizoma corydalis activates blood, moves qi and relieves pain, and the two medicines are matched with each other to dispel heat and relieve pain, so that qi stagnation in blood can be caused, and the qi stagnation and blood stagnation can enhance the effect of relieving pain, and the two medicines are jointly used as ministerial medicines; pollen typhae, which can promote blood circulation to remove blood stasis, leech, which can remove blood stasis and remove meridian obstruction, motherwort, which can promote blood circulation to regulate menstruation, and radix cyathulae, which can promote menstruation and draw blood downwards, are taken as adjuvant drugs; the honey-fried licorice root is used as a guiding drug for harmonizing various drugs. The whole formula has the effects of warming channels for dispelling cold, removing blood stasis and relieving dysmenorrheal, and dredging collaterals and pain, and has obvious curative effect on female cold coagulation blood stasis type dysmenorrheal.
Compared with the prior art, the invention has the beneficial effects that:
in the invention, from the viewpoints of long-term disease collateral entering and long-term pain collateral entering, the invention has the characteristic of dialectical medication, and various functional collateral medicines are added, so that the invention has the effects of warming channels, dispelling cold, removing blood stasis and relieving dysmenorrheal, and can well relieve dysmenorrhea symptoms caused by cold coagulation and blood stasis. Based on the above, the traditional Chinese medicine composition disclosed by the invention is simple to prepare, low in cost, good in treatment effect on cold coagulation and blood stasis type dysmenorrhea, high in cure rate, definite in curative effect, not easy to relapse, good in safety, free of adverse reaction and good in market prospect.
Detailed Description
The present invention will be described in further detail with reference to examples in order to make the objects and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The instruments, reagents, materials, etc. used in the following examples are conventional instruments, reagents, materials, etc. known in the art, and are commercially available. The experimental methods, detection methods, and the like in the following examples are conventional experimental methods, detection methods, and the like existing in the prior art unless otherwise specified.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea, which is prepared from the following raw materials in parts by weight: 8g of rhizoma corydalis, 6g of prepared aconite root, 10g of mugwort leaf, 8g of prepared ginger, 6g of cattail pollen, 20g of motherwort, 10g of medicinal cyathula root, 2g of leech and 7g of honey-fried licorice root.
The traditional Chinese medicine composition is prepared by the following preparation method:
s1: taking rhizoma corydalis, radix aconiti lateralis preparata, folium artemisiae argyi, rhizoma zingiberis preparata, pollen typhae, motherwort, medicinal cyathula root, leech and honey-fried licorice root according to weight for standby;
s2: adding the prepared aconite into boiled water with the mass of 20 times for decocting for 1h, adding the rest raw materials into the mixture, adding water with the mass of 10 times for supplementing, continuously decocting for 30min, filtering, adding water with the mass of 6 times into the filter residue again for decocting for 20min, filtering, and combining 2 times of filtrate to obtain a decoction; concentrating the decoction by reduced pressure evaporation at 50deg.C to obtain extract with relative density of 1.25;
s3: mixing the extract with pharmaceutically acceptable medicinal adjuvants, and making into tablet.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea, which is prepared from the following raw materials in parts by weight: 12g of rhizoma corydalis, 8g of prepared aconite root, 12g of mugwort leaf, 10g of prepared ginger, 8g of cattail pollen, 30g of motherwort, 12g of medicinal cyathula root, 3g of leech and 6g of honey-fried licorice root.
The traditional Chinese medicine composition is prepared by the following preparation method:
s1: taking rhizoma corydalis, radix aconiti lateralis preparata, folium artemisiae argyi, rhizoma zingiberis preparata, pollen typhae, motherwort, medicinal cyathula root, leech and honey-fried licorice root according to weight for standby;
s2: adding the prepared aconite into boiled water with the mass of 20 times for decocting for 1h, adding the rest raw materials into the mixture, adding water with the mass of 10 times for supplementing, continuously decocting for 30min, filtering, adding water with the mass of 6 times into the filter residue again for decocting for 20min, filtering, and combining 2 times of filtrate to obtain a decoction; concentrating the decoction by evaporation under reduced pressure at 52deg.C to obtain extract with relative density of 1.28;
s3: mixing the extract with pharmaceutically acceptable medicinal adjuvants, and making into capsule.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea, which is prepared from the following raw materials in parts by weight: 15g of rhizoma corydalis, 10g of prepared aconite root, 15g of mugwort leaf, 12g of prepared ginger, 10g of cattail pollen, 25g of motherwort, 15g of medicinal cyathula root, 2.5g of leech and 8g of honey-fried licorice root.
The traditional Chinese medicine composition is prepared by the following preparation method:
s1: taking rhizoma corydalis, radix aconiti lateralis preparata, folium artemisiae argyi, rhizoma zingiberis preparata, pollen typhae, motherwort, medicinal cyathula root, leech and honey-fried licorice root according to weight for standby;
s2: adding the prepared aconite into boiled water with the mass of 20 times for decocting for 1h, adding the rest raw materials into the mixture, adding water with the mass of 10 times for supplementing, continuously decocting for 30min, filtering, adding water with the mass of 6 times into the filter residue again for decocting for 20min, filtering, and combining 2 times of filtrate to obtain a decoction; concentrating the decoction by reduced pressure evaporation at 55deg.C to obtain extract with relative density of 1.30;
s3: mixing the extract with pharmaceutically acceptable medicinal adjuvants, and making into pill.
Example 4
The difference from example 2 is that the prepared traditional Chinese medicine composition is granule.
Example 5
The difference from example 2 is that the prepared traditional Chinese medicine composition is powder.
Example 6
The difference from example 2 is that the prepared traditional Chinese medicine composition is a decoction.
Clinical experiments are carried out by using the traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea, and the following processes and results of the clinical experiments are as follows:
1. basic data: 156 female patients are treated in the same way from 1 month in 2020 to 10 months in 2023, and the ages are 15 to 34.
2. Diagnostic criteria: western medicine diagnosis Standard reference Xie Xing et al Main code "women obstetrics science" (national sanitation Press, 9 th edition) dysmenorrhoea diagnosis Standard: pain and distention of the lower abdomen, which are usually severe on the 1 st day of the menstrual period, are caused before and after the menstrual period, and even the discomfort such as waist soreness, nausea and cold sweat are caused, so that organic lesions are not seen in gynecological and ultrasonic examination.
The main editions of Chinese medicine clinical guidelines (published 2002) of new medicines of Chinese medicine (Yong, new century fourth edition of teaching materials) of Chinese medicine diagnosis reference Zhengyu and the like.
Main symptoms are as follows: premenstrual or menstrual lower abdomen cold pain is refused to press, and the pain occurrence time is related to menstrual cycle.
Secondary symptoms: menstruation or the like with a push-back, the amount is small, and menstruation is dark and has blood stasis; pale complexion, cold limbs and aversion to cold. Tongue appearance: a dark or purple tongue, a tongue with a thin and white coating, and a tongue with a dark or purple tongue.
Pulse condition: the pulse is deep and tense or deep and astringent.
3. The treatment method comprises the following steps: the capsule prepared in this example 2 (capsule for warming channel, dredging collaterals and relieving pain) was administered: taken three times a day, 5 granules each time (1 after 1 week # Capsule shell, content weight of medicine is 0.5 g), and is taken with warm boiled water for continuous administration until the fifth day of menstrual cycle, and 3 menstrual cycles are used.
4. Standard of efficacy: adopting the guidelines of clinical research on new traditional Chinese medicines, and judging the total curative effect by calculating the integral before and after, wherein the integral standard of each main symptom is as follows: no 0 part, light weight of 2 parts, medium weight of 4 parts and heavy weight of 6 parts; the integral criteria for each symptom are: no 0min, light 1 min, medium 2 min and heavy 3 min. The formula is: the total therapeutic effect index of the traditional Chinese medicine syndrome (n) = [ (pre-treatment integral-post-treatment integral)/pre-treatment integral ] ×100%. The curative effect and the like are classified into cure, obvious effect, effective and ineffective according to the 2002 edition standard of the new traditional Chinese medicine clinical research guidelines. Grade specific standard: and (3) healing: dysmenorrhea and other uncomfortable symptoms basically disappear after the medicine is taken, and n is more than or equal to 95%; the effect is shown: the uncomfortable symptoms are obviously relieved after the medicine is taken, and n is more than or equal to 70 and less than 95 percent; the method is effective: the discomfort symptoms are relieved after the medicine is taken, and n is more than or equal to 30 and less than 70 percent; invalidation: after taking the medicine, the symptoms of dysmenorrhea and other discomforts are unchanged, and n is less than 30%.
5. Therapeutic results
As can be seen from Table 1, the total effective rate of the traditional Chinese medicine composition of example 2 on treating cold coagulation stasis type dysmenorrhea can reach 94.87%, which shows that the traditional Chinese medicine composition of the example has good treatment effect and definite curative effect on cold coagulation stasis type dysmenorrhea.
TABLE 1
6. Typical cases
Case 1: name: some women, 22 years old, 2022.7.10 first visit. Complaints: abdominal pain during menstruation for more than 10 years. The current medical history: plain menstruation, 12 years of menstrual beginnings, 28-30 days in period, 7 days in menstrual period, 2022.6.20 in last menstrual period, dark red, and blood clot. Before 10 years, after menstrual period, cold pain in the lower abdomen during menstruation can be relieved after hot compress due to the greedy cold drink, and the pain is not treated. And then, the pain is relieved by taking the analgesic prescription every time the cold pain in the lower abdomen occurs periodically before and during menstrual period, the pain is severe, the aversion to cold, the cold hands and feet are cold, the tongue is dark red, the tongue is provided with a blood stasis point under the tongue, the tongue coating is thin and white, and the pulse is deep and astringent. Diagnosis: dysmenorrhea (cold coagulation and blood stasis syndrome). The decoction of example 6 (decoction for warming channels and dredging collaterals and relieving pain) was administered by therapy, and 100mL each time was taken after 1 week before the next menstrual period, twice daily. The administration is continued until the fifth day of the next menstrual cycle. After 3 menstrual cycles, symptoms such as dysmenorrhea, aversion to cold, cold hands and feet and the like disappear, and no recurrence occurs after continuous follow-up for 3 months.
Case 2: the patient was first diagnosed with a certain king, female, 21 years old, 2021, 5 months and 15 days old. Complaints: abdominal pain during menstruation for 6 years. The current medical history: the patients can not learn normally due to the severe pain of lower abdomen in the first to third days of menstrual period, which is caused by the severe pain of lower abdomen with nausea and vomiting after the menstrual period is 6 years ago, and the patients have little menstrual period and blood clots and large intimal tissues, and even the pain is caused under the block, the pain is slightly relieved. Menstrual period is 15 years, period is 27-30 days, menstrual period is 5-7 days, last menstrual period is 2021.4.28, and breast pain is caused 1 week before menstrual period. Plain is preferred to eat cold drink, cold pain in lower abdomen and cold hands and feet. Checking: the abdomen is soft, the whole abdomen has no tenderness and rebound pain, and the patient with the Murray point tenderness (-) Murray sign (-) does not receive wedding gynecological examination. A pale tongue with a white and moist coating, a thin and white coating, a deep pulse and a weak ruler. Auxiliary inspection: gynaecology's B ultrasonic shows: anterior uterine position, size 5.5cm×2.9cm×2.3cm, endometrium thickness 0.9cm; left ovarian size 2.9cm×2.6cm, right ovarian size 3.1cm×2.8cm for TCM diagnosis: dysmenorrhea (cold coagulation and blood stasis syndrome). The decoction of example 6 (decoction for warming channels and dredging collaterals and relieving pain) was administered for 1 week before the next menstrual period, 100mL each time, twice daily, and twice daily for the fifth day of the next menstrual period. After 3 menstrual cycles, the symptoms of cold pain in the lower abdomen and cold hands and feet of the patient disappear, and the menstruation volume is normal without blood clots. No recurrence occurred for 6 months following the follow-up.
Case 3: patient Yu Mou, female, 16 years old, complaint: cold pain in the lower abdomen during menstruation is more than 2 years. Self-complaints: dysmenorrhea occurs after menstrual period 14 years of age and early stage, aversion to cold, lower abdomen distention and cold pain of lower abdomen refuses to press in the first day of menstrual period, and symptoms of dark and hard menstrual blood, nausea and syncope are caused, and pain relieving medicine needs to be injected into hospitals. A dark purple tongue with a thin and white coating and a deep and astringent pulse. Diagnosis: dysmenorrhea (cold coagulation and blood stasis syndrome). The decoction of example 6 (decoction for warming channels and dredging collaterals and relieving pain) was administered for 1 week before the next menstrual period, 100mL each time, twice daily, and twice daily for the fifth day of the next menstrual period. After 3 menstrual cycles are used, the symptoms of cold pain of the lower abdomen of the patient during menstruation are obviously relieved, the patient can tolerate the cold pain, and the menstruation volume is increased, and the patient turns red without blood clots. And the patients are healed after taking two menstrual cycles, and the patients do not relapse after continuous follow-up for 3 months.
In conclusion, the traditional Chinese medicine composition has good treatment effect on cold coagulation and blood stasis type dysmenorrhea, high cure rate, definite curative effect, difficult recurrence, good safety and no adverse reaction.
The foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the precise form disclosed, and any such modifications, equivalents, and alternatives falling within the spirit and scope of the invention are intended to be included within the scope of the invention.
Claims (6)
1. A traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-15 parts of rhizoma corydalis, 6-10 parts of prepared aconite, 10-15 parts of mugwort leaf, 8-12 parts of prepared ginger, 6-10 parts of pollen typhae, 20-30 parts of motherwort, 10-15 parts of medicinal cyathula root, 2-3 parts of leech and 6-8 parts of honey-fried licorice root.
2. The traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea according to claim 1, wherein the traditional Chinese medicine composition is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12 parts of rhizoma corydalis, 8 parts of prepared aconite root, 12 parts of mugwort leaf, 10 parts of prepared ginger, 8 parts of cattail pollen, 30 parts of motherwort, 12 parts of medicinal cyathula root, 3 parts of leech and 6 parts of honey-fried licorice root.
3. The traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea according to claim 1, wherein the traditional Chinese medicine composition is characterized in that: the traditional Chinese medicine composition is prepared by the following preparation method:
s1: taking rhizoma corydalis, prepared aconite root, mugwort leaf, prepared ginger, cattail pollen, motherwort, medicinal cyathula root, leech and honey-fried licorice root according to parts by weight for standby;
s2: adding the prepared aconite into boiled water for decoction, adding the rest raw materials into the mixture, adding water, continuously decocting, filtering, adding water into filter residues again for decoction, filtering, and combining 2 times of filtrate to obtain a decoction; concentrating the decoction under reduced pressure to obtain extract;
s3: mixing the extract with pharmaceutically acceptable medicinal adjuvants, and making into the Chinese medicinal composition.
4. The traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea according to claim 3, wherein the traditional Chinese medicine composition is characterized in that: in the step S2, the mass ratio of the prepared aconite root to the boiled water is 1:20, and the decocting time is 1h; the mass ratio of the residual raw material medicines to water is 1:10, and the decocting time is 30min; the mass ratio of the filter residue to the water is 1:6, and the decoction time is 20min.
5. The traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea according to claim 3, wherein the traditional Chinese medicine composition is characterized in that: in the step S2, the temperature of reduced pressure evaporation is 50-55 ℃, and the relative density of the extract is 1.25-1.30.
6. The traditional Chinese medicine composition for treating cold coagulation stasis type dysmenorrhea according to claim 3, wherein the traditional Chinese medicine composition is characterized in that: in the step S3, the dosage form of the traditional Chinese medicine composition is a clinically acceptable oral preparation, preferably a tablet, a capsule, a pill, a granule, a powder or a decoction.
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| CN (1) | CN117883541A (en) |
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2023
- 2023-12-22 CN CN202311780184.3A patent/CN117883541A/en active Pending
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