CN117881287A - Quantitative spray aerosol product for controlling harmful microorganism and method for controlling harmful microorganism using the same - Google Patents
Quantitative spray aerosol product for controlling harmful microorganism and method for controlling harmful microorganism using the same Download PDFInfo
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- CN117881287A CN117881287A CN202280058149.8A CN202280058149A CN117881287A CN 117881287 A CN117881287 A CN 117881287A CN 202280058149 A CN202280058149 A CN 202280058149A CN 117881287 A CN117881287 A CN 117881287A
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- Prior art keywords
- spray
- aerosol
- quantitative
- harmful microorganisms
- controlling
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- DDVNRFNDOPPVQJ-HQJQHLMTSA-N transfluthrin Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC1=C(F)C(F)=CC(F)=C1F DDVNRFNDOPPVQJ-HQJQHLMTSA-N 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
- A01M7/00—Special adaptations or arrangements of liquid-spraying apparatus for purposes covered by this subclass
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
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- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
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- Wood Science & Technology (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Nozzles (AREA)
Abstract
The present invention provides a quantitative spray aerosol product for controlling harmful microorganisms, which can exert excellent control effect on harmful microorganisms by uniformly attaching a sufficient amount of harmful microorganism control components on the upper parts of a ceiling, a wall surface and the like. A quantitative spray aerosol product for controlling harmful microorganisms in an indoor space, comprising an aerosol container provided with a quantitative spray valve and containing an aerosol stock solution containing a harmful microorganism control component and a spray agent, and a spray member provided with a spray port connected to the quantitative spray valve, wherein 50% of the particle diameter in the cumulative distribution of the volumes of spray particles formed when the spray member is operated to spray an aerosol collagen solution in the aerosol container at 25 ℃ and a distance of 30cm from the spray port is adjusted to 17 to 120 [ mu ] m.
Description
Technical Field
The present invention relates to a quantitative spray aerosol product for controlling harmful microorganisms in an indoor space and a method for controlling harmful microorganisms using the same.
Background
In order to control harmful microorganisms such as mold in indoor spaces such as bathrooms and toilets, it has been conventionally carried out using a fumigation device (for example, see patent document 1) or a full-spray type aerosol product (for example, see patent document 2).
The mildew-proof fumigation apparatus for a bathroom of patent document 1 includes a heating unit and a metallic fumigant container located above the heating unit. In use, water is added to the calcium oxide stored in the heating unit, and the fumigant in the fumigant container is formed into smoke by the reaction heat, and the treatment target space is filled with the smoke.
The full-injection type aerosol product of patent document 2 is a product obtained by filling a pressure vessel with a solvent having a boiling point of 70 to 200 ℃ and an injection agent containing dimethyl ether at a predetermined ratio in addition to an inorganic chemical. In use, the user locks the spray button in a depressed state in a state in which the aerosol product is placed on a floor surface. Thereby, the chemical is filled in the processing target space in the form of ejected particles until the air pressure in the pressure vessel is lost.
Prior art literature
Patent literature
Patent document 1: japanese patent application laid-open No. 2015-91876
Patent document 2: japanese patent laid-open publication No. 2014-227369
Disclosure of Invention
Problems to be solved by the invention
The mildewproof fungus smoking device for bathroom of patent document 1 and the full-spray type aerosol product of patent document 2 are considered to prevent the generation of harmful microorganisms such as fungus for a certain period of time after use by one treatment, but each time the used fumigant or the full-spray type aerosol is discarded, the time and effort are required. In addition, if the treatment space is not completely sealed, a part of the smoke or the chemical may leak to the outside during the treatment, and careful preparation is required.
Further, since harmful microorganisms such as mold and fungus are likely to be generated and propagated in the upper part of the ceiling and wall surface, etc., which are not easily cleaned thoroughly, it is important to design a formulation suitable for use in particular when an indoor space such as a bath or a toilet is used as a treatment object. However, there has heretofore been no product capable of controlling harmful microorganisms such as mold in a high place by a simple operation in a space, and development of a product having high convenience and effectiveness in place of a fumigant or a full-spray type aerosol has been desired.
The present invention has been made in view of the above-described problems, and an object of the present invention is to provide a quantitative spray aerosol product for controlling harmful microorganisms, which can exert an excellent control effect on harmful microorganisms by uniformly adhering a sufficient amount of harmful microorganism control components to the ceiling, the upper part of the wall surface, and the like; and a method for controlling harmful microorganisms using the same.
Means for solving the problems
The quantitative spray aerosol product for controlling harmful microorganisms of the present invention for solving the above problems is characterized in that,
a quantitative spray aerosol product for controlling harmful microorganisms, which is used for controlling harmful microorganisms in an indoor space, comprising:
an aerosol container provided with a quantitative injection valve in which an aerosol stock solution containing a harmful microorganism control component and an injection agent are enclosed, and
an injection member provided with an injection port connected to the quantitative injection valve,
the particle diameter of 50% of the volume cumulative distribution of the spray particles formed when the aerosol collagen liquid in the aerosol container is sprayed by operating the spray member is adjusted to 17 to 120 [ mu ] m at 25 ℃ at a distance of 30cm from the spray orifice.
According to the quantitative spray aerosol product for controlling harmful microorganisms of the present configuration, since the particle diameter of spray particles formed by spraying (50% of particle diameter in the cumulative volume distribution at a distance of 30cm from the spray orifice at 25 ℃) is adjusted to the above-described specific range, the spray particles reach the ceiling, the upper part of the wall surface, and the like of the indoor space where harmful microorganisms are likely to be generated and propagated, and thereby the harmful microorganism control component is sufficiently and uniformly adhered to the above-described high place. As a result, an excellent control effect against harmful microorganisms will be exhibited.
In the quantitative spray aerosol product for controlling harmful microorganisms of the present invention, it is preferable that,
the injection capacity of the quantitative injection valve for 1 time is 0.08 mL-3.0 mL.
According to the quantitative spray aerosol product for controlling harmful microorganisms of the present configuration, since the spray capacity of the quantitative spray valve for 1 time is set in the above-described proper range, the harmful microorganism control component contained in the spray particles can be sufficiently and uniformly adhered to the ceiling, the upper part of the wall surface, and the like only by operating the spray member a predetermined number of times according to the size of the indoor space, and the quantitative spray aerosol product is suitable for use in the indoor space.
In the quantitative spray aerosol product for controlling harmful microorganisms of the present invention, it is preferable that,
the volume ratio (a/b) of the aerosol collagen liquid (a) to the propellant (b) enclosed in the aerosol container is 5/95 to 70/30.
According to the quantitative spray aerosol product for controlling harmful microorganisms of the present configuration, the volume ratio (a/b) is set in the above-described proper range, so that the spray particles do not remain excessively in the air and can reliably reach the ceiling, the upper part of the wall surface, and the like.
In the quantitative spray aerosol product for controlling harmful microorganisms of the present invention, it is preferable that,
The volume of the indoor space is 2.0m 3 ～25.0m 3 。
According to the quantitative spray aerosol product for controlling harmful microorganisms of the present constitution, excellent control effects against harmful microorganisms can be exhibited in an indoor space corresponding to the above-mentioned volume, for example, in a bathroom, a dressing room, a bathroom, a toilet, a wardrobe, a closet, an automobile, a tent, a warehouse, a storage room, a garage, a vestibule, and the like.
In the quantitative spray aerosol product for controlling harmful microorganisms of the present invention, it is preferable that,
the release amount of the harmful microorganism control ingredient is set to 0.01mg/m 3 ～250mg/m 3 。
According to the quantitative spray aerosol product for controlling harmful microorganisms of the present constitution, the release amount of the harmful microorganism controlling component is set to the above-described proper range, and therefore, excellent controlling effect against harmful microorganisms can be exhibited in the indoor space.
The method for controlling a harmful microorganism according to the present invention for solving the above-mentioned problems is characterized in that,
the quantitative spray aerosol product for controlling harmful microorganisms is used to spray the aerosol product into an indoor space.
According to the method for controlling harmful microorganisms of the present constitution, by simply performing the spraying treatment in the indoor space using the quantitative spraying aerosol product for controlling harmful microorganisms, the sprayed particles are allowed to reach the ceiling, the upper part of the wall surface, etc. of the indoor space where the harmful microorganisms are likely to be generated and propagated, whereby the harmful microorganism controlling components are sufficiently and uniformly adhered to the high place. As a result, an excellent control effect against harmful microorganisms will be exhibited.
In the method for controlling a harmful microorganism of the present invention, it is preferable that,
the volume of the indoor space is 2.0m 3 ～25.0m 3 。
According to the method for controlling harmful microorganisms of the present constitution, excellent control effects against harmful microorganisms can be exhibited in an indoor space corresponding to the above-mentioned volume, for example, in a bathroom, a dressing room, a toilet, a wardrobe, a closet, an automobile, a tent, a warehouse, a storage room, a garage, a vestibule, and the like.
In the method for controlling a harmful microorganism of the present invention, it is preferable that,
the release amount of the above-mentioned harmful microorganism control ingredient is 0.01mg/m 3 ～250mg/m 3 In the above method, the quantitative spray aerosol product for controlling harmful microorganisms is sprayed.
According to the method for controlling harmful microorganisms of the present constitution, the quantitative injection aerosol product for controlling harmful microorganisms is injected so that the release amount of the harmful microorganism controlling component falls within the above-mentioned proper range, whereby an excellent controlling effect against harmful microorganisms can be exerted in the indoor space.
Detailed Description
The present inventors have made an intensive study on the adhesion of a harmful microorganism control ingredient to a ceiling, an upper part of a wall surface, etc., and as a result, have found that, in a quantitative spray aerosol product for controlling harmful microorganisms, the adhesion and diffusion uniformity of a harmful microorganism control ingredient to a ceiling, an upper part of a wall surface, etc. can be remarkably improved by adjusting 50% of the particle diameter in the cumulative volume distribution at a distance of 30cm from the spray opening to a specific range, and have completed the present invention. Hereinafter, the quantitative spray aerosol product for controlling harmful microorganisms and the method for controlling harmful microorganisms according to the present invention will be described. However, the present invention is not limited to the configurations described below. In the present specification, when the symbols "-" indicating the range are present, the upper limit and the lower limit are defined.
[ quantitative spray aerosol product for controlling harmful microorganism ]
The quantitative spray aerosol product for controlling harmful microorganisms of the present invention is a quantitative spray aerosol product used for controlling harmful microorganisms in an indoor space. The quantitative spray aerosol product for preventing and killing harmful microorganisms comprises an aerosol container provided with a quantitative spray valve and a spray button provided with a spray orifice connected with the quantitative spray valve. An aerosol stock solution containing a harmful microorganism control component and a propellant are enclosed in an aerosol container. The term "harmful microorganism" as used herein refers to a living organism or a substance derived from a living organism such as bacteria, mold, virus, etc. In the present invention, the "indoor space" is a space in a building or the like, and may be less than 2.0m 3 Is 2.0m 3 ～18.8m 3 The volume of the room corresponding to 4.5-8 tatami in the narrow space is 18.8m 3 ～33.3m 3 Left and right (7.5 m area) 2 ～13.3m 2 A height of 2.2 m-3.0 m) and a room volume of 33.3m corresponding to 8-16 tatami 3 ～66.6m 3 Left and right (13.3 m area) 2 ～26.6m 2 A height of 2.2m to 3.0 m), a wide indoor space, and the like are not particularly limited. The "small space" in which the quantitative spray aerosol product for controlling harmful microorganisms of the present invention exhibits particularly excellent effects is assumed to have a volume of 2.0m 3 ～18.8m 3 Examples of the left and right spaces include closed or semi-closed spaces such as bathrooms, dressing rooms, toilets, cupboards, closets, automobiles, tents, warehouses, storerooms, garages, and hallways. More specifically, for example, as a volume of 2.0m 3 ～3.0m 3 Examples of the small space of (2) include a toilet, etc., and the volume is 3.0m 3 ～18.8m 3 Examples of the narrow space include a bathroom. The quantitative spray aerosol product for controlling harmful microorganisms of the present invention is a quantitative spray typeSince the amount of the chemical to be sprayed is small, and the particle size of the spray particles (in particular, 50% of the particle size in the cumulative volume distribution at a distance of 30cm from the spray opening at 25 ℃) formed when the spray button is pressed to spray the aerosol-containing liquid in the aerosol container is appropriately adjusted, an excellent control effect against harmful microorganisms is achieved. In the present specification, the effect of preventing the growth of harmful microorganisms in an environment where the growth and the growth of harmful microorganisms are difficult or the presence of harmful microorganisms is difficult, and the effect of preventing the growth of harmful microorganisms by killing the harmful microorganisms are collectively referred to as a control effect. For example, when a mold is to be controlled, the control effect includes a mold control effect and a mold killing effect.
< aerosol collagen solution >
Examples of the harmful microorganism-controlling component contained in the aerosol-generating liquid include a bacterial-controlling component, a mold-controlling component, a virus-controlling component, and the like. The above-mentioned harmful microorganism control components may be used singly or in combination of plural kinds. In the case where the chiral carbon-based optical isomer or the double bond-based geometric isomer is present in the harmful microorganism control component, each of them alone or in any combination is also included in the present invention.
The bacterial control component is not particularly limited, examples thereof include isopropyl methylphenol (IPMP), carvacrol, thymol, triclosan, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, 4-chloro-3, 5-dimethylphenol, phenol-based bacterial control components such as o-cresol, m-cresol and p-cresol, dimethyl ammonium salts such as benzalkonium chloride, benzalkonium methosulfate, benzalkonium salts such as benzalkonium organic acid salts, benzethonium chloride, benzethonium methosulfate, benzethonium salts such as benzethonium organic acid salts, cetyl pyridinium chloride, cetyl pyridinium methosulfate, cetyl pyridinium salts such as cetyl pyridinium organic acid salts, didecyl dimethyl ammonium salts such as didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium chloride such as didecyl dimethyl ammonium methyl sulfate, distearyl dimethyl ammonium salts such as distearyl dimethyl ammonium chloride, distearyl dimethyl ammonium salts such as distearyl dimethyl ammonium methyl sulfate, and 1, 4-bis [3, 3-decyl methyl pyridinium chloride ] and 1, 3-bis [ 1, 3-decyl pyridinium oxide ] and 1, 3-bis [ 1, 3-decyl pyridinium oxide ] butyl p-1, 3-bis (1, 4-decyl) um oxide and 1, 3-bis (1, 4-decyl) butanone oxide) of the active ingredient such as methyl sulfate, biguanide bacteria control component, azole bacteria control component such as tebuconazole, imazalil (enilconazole) and the like, grapefruit seed extract, persimmon seed extract, fruit seed extract and the like, glycerol monolaurate such as glycerol monocaprylate, chlorhexidine gluconate, chlorhexidine salts such as chlorhexidine hydrochloride and the like, chlorhexidine bacteria control component such as chlorhexidine, octadecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, dodecyl dimethyl (3-triethoxysilylpropyl) ammonium chloride, dodecyl diisopropyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldiethyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldi-n-propyl (3-triethoxysilylpropyl) ammonium chloride, pentadecyl dimethyl (3-triethoxysilylpropyl) ammonium chloride, hexadecylpropyl) ammonium chloride, and the like, silicon-based bacteria control components such as hexadecyldi-N-propyl (3-triethoxysilylpropyl) ammonium chloride, octadecyl diethyl (3-triethoxysilylpropyl) ammonium chloride, silicon-based bacteria control components such as octadecyl di-N-propyl (3-triethoxysilylpropyl) ammonium chloride, benzoic acid, salicylic acid, sorbic acid, ethylenediamine tetraacetic acid (EDTA), glycine, alkyldiethylaminoglycine, polylysine and the like carboxylic acid-based bacteria control components or salts thereof, dehydroacetic acid, chloramine, 3-iodo-2-propynyl-N-butylcarbamate (IPBC), silver-based bacteria control components such as phenoxyethanol, silver ions, silver zeolite, zinc pyrithione, thiamine lauryl sulfate, fish albumin, hydroxyalkyl chitosan or salts thereof, and the like. Among these bacterial control components, isopropyl methylphenol (IPMP), carvacrol, thymol, benzalkonium chloride, 1, 4-bis [3,3' - (1-decylpyridinium) methyloxy ] butane dibromide, glyceryl monocaprylate, and tebuconazole are preferred. The above-mentioned bacterial control components may be used singly or in combination of two or more.
The mold control component is not particularly limited, examples thereof include isopropyl methylphenol (IPMP), carvacrol, thymol, triclosan, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, 4-chloro-3, 5-dimethylphenol, phenol-type mold-removing components such as o-cresol, m-cresol and p-cresol, benzalkonium chloride, benzalkonium methosulfate, benzalkonium salts such as benzalkonium organic acid salts, benzethonium chloride, benzethonium methosulfate, benzethonium salts such as benzethonium organic acid salts, cetyl pyridinium chloride, cetyl pyridinium methosulfate, cetyl pyridinium salts such as cetyl pyridinium organic acid salts, didecyl dimethyl ammonium salts such as didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium chloride such as didecyl dimethyl ammonium methyl sulfate, distearyl dimethyl ammonium salts such as distearyl dimethyl ammonium chloride, 1, 4-bis [3, 3-decyl dimethyl ammonium methyl sulfate ] and 1, 3-bis [ 1, 3-decyl pyridinium methyl 1, 3-oxo-1, 3-decyl pyridinium methyl-1, 3-bis [ 1, 3-decyl pyridinium methyl-3-oxo-1, 3-dimethyl-butanium chloride ] and the like, the components for controlling the amount of the biguanide mold, the components for controlling the amount of the azole mold such as tebuconazole and imazalil, the grapefruit seed extract, the persimmon seed extract and the fruit seed extract such as grape seed extract, the components for controlling the amount of the glycerin monofatty acid ester mold such as glycerin monolaurate, glycerin monocaprylate and glycerin monocaprylate, chlorhexidine gluconate, chlorhexidine salt such as chlorhexidine, the components for controlling the amount of the chlorhexidine mold such as chlorhexidine, octadecyl dimethyl (3-triethoxysilylpropyl) ammonium chloride, dodecyl diisopropyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldiethyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldi-n-propyl (3-triethoxysilylpropyl) ammonium chloride, pentadecyl dimethyl (3-triethoxysilylpropyl) ammonium chloride, pentadecyl diethyl (3-triethoxysilylpropyl) ammonium chloride, pentadecyl di-n-propyl (3-triethoxysilylpropyl) ammonium chloride, hexadecylpropyl (3-triethoxysilylpropyl) ammonium chloride, and hexadecylpropyl (3-triethoxysilylpropyl) ammonium chloride, and a silicone mold control component such as octadecyldiethyl (3-triethoxysilylpropyl) ammonium chloride or octadecyldi-N-propyl (3-triethoxysilylpropyl) ammonium chloride, a carboxylic mold control component such as benzoic acid, salicylic acid, sorbic acid, ethylenediamine tetraacetic acid (EDTA), glycine, alkyldiethylaminoglycine, polylysine, or a salt thereof, a silver mold control component such as dehydroacetic acid, chloramine, 3-iodo-2-propynyl-N-butylcarbamate (IPBC), phenoxyethanol, silver ions, silver zeolite, zinc pyrithione, thiamine lauryl sulfate, fish albumin, hydroxyalkyl chitosan or a salt thereof, and a mold control perfume. Among these mold control components, isopropyl methylphenol (IPMP), carvacrol, thymol, benzalkonium chloride, 1, 4-bis [3,3' - (1-decylpyridinium) methyloxy ] butane dibromide, glyceryl monocaprylate, and tebuconazole are preferred. The above-mentioned mold control components may be used singly or in combination of two or more kinds.
The virus-controlling component is not particularly limited, examples thereof include isopropyl methylphenol (IPMP), carvacrol, thymol, triclosan, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, 4-chloro-3, 5-dimethylphenol, phenol virus-controlling components such as o-cresol, m-cresol and p-cresol, dimethyl ammonium chloride, benzalkonium methosulfate, benzalkonium salts such as benzalkonium organic acid salts, benzethonium chloride, benzethonium methosulfate, benzethonium salts such as benzethonium organic acid salts, cetyl pyridinium chloride, cetyl pyridinium methosulfate, cetyl pyridinium salts such as cetyl pyridinium organic acid salts, didecyl dimethyl ammonium salts such as didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium chloride such as didecyl dimethyl ammonium methyl sulfate, distearyl dimethyl ammonium salts such as distearyl dimethyl ammonium chloride, 1, 4-bis [3, 3-decyl dimethyl ammonium methyl sulfate ] and 1, 3-bis [ 1, 3-decyl pyridinium methyl 1, 3-dimethyl-1' - (1, 3-dimethyl-4-decyl pyridinium methyl-1, 3-d 1-butyl-1-dioxetum chloride, 3-bis [ 1, 3-decyl pyridinium methyl-3-d-propyl pyridinium bromide ] and the like, biguanide virus control ingredient, azole virus control ingredient such as tebuconazole and imazalil, fruit seed extract such as grapefruit seed extract, persimmon seed extract and grape seed extract, glycerin monofatty acid ester virus control ingredient such as glycerin monolaurate, glycerin monocaprylate and glycerin monocaprylate, chlorhexidine salt such as chlorhexidine gluconate and chlorhexidine hydrochloride, chlorhexidine virus control ingredient such as chlorhexidine, octadecyl dimethyl (3-triethoxysilylpropyl) ammonium chloride, dodecyl diisopropyl (3-triethoxysilylpropyl) ammonium chloride tetradecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldiethyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldi-n-propyl (3-triethoxysilylpropyl) ammonium chloride, pentadecyl dimethyl (3-triethoxysilylpropyl) ammonium chloride, pentadecyl diethyl (3-triethoxysilylpropyl) ammonium chloride, pentadecyl di-n-propyl (3-triethoxysilylpropyl) ammonium chloride, hexadecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, hexadecyldiethyl (3-triethoxysilylpropyl) ammonium chloride, hexadecyldi-n-propyl (3-triethoxysilylpropyl) ammonium chloride, silicon virus control components such as octadecyl diethyl (3-triethoxysilylpropyl) ammonium chloride and octadecyl di-N-propyl (3-triethoxysilylpropyl) ammonium chloride, carboxylic virus control components such as benzoic acid, salicylic acid, sorbic acid, ethylenediamine tetraacetic acid (EDTA), glycine, alkyldiethylaminoglycine, polylysine, or salts thereof, silver virus control components such as dehydroacetic acid, chloramine, 3-iodo-2-propynyl-N-butylcarbamate (IPBC), phenoxyethanol, silver ions, silver zeolite, zinc pyrithione, thiamine lauryl sulfate, fish albumin, hydroxyalkyl chitosan, or salts thereof, and the like. Among these virus control components, isopropyl methylphenol (IPMP), carvacrol, thymol, benzalkonium chloride, 1, 4-bis [3,3' - (1-decylpyridinium) methyloxy ] butane dibromide, glyceryl monocaprylate, and tebuconazole are preferred. The virus-controlling component may be used alone or in combination of two or more.
The content of the harmful microorganism control component in the aerosol stock solution is not particularly limited, and may be 0.01w/v% to 80w/v%, preferably 0.01w/v% to 70w/v%, more preferably 0.05w/v% to 50w/v%, and still more preferably 0.1w/v% to 40w/v%. If the content of the harmful microorganism control component in the aerosol-type collagen liquid is within the above-described range, an appropriate control effect against harmful microorganisms can be obtained in the indoor space.
The aerosol stock solution may contain a solvent. Examples of such solvents include, but are not particularly limited to, lower alcohol solvents having 2 to 3 carbon atoms such as ethanol, 1-propanol and isopropyl alcohol (IPA), hydrocarbon solvents having 4 to 10 carbon atoms such as normal paraffins (isoparaffin), higher fatty acid ester solvents having 16 to 22 carbon atoms such as isopropyl myristate (IPM), isopropyl palmitate, isobutyl oleate and butyl stearate, glycol ether solvents having 3 to 10 carbon atoms such as diethylene glycol monobutyl ether, dipropylene glycol monobutyl ether and tripropylene glycol monomethyl ether, glycol solvents having 3 to 10 carbon atoms such as dipropylene glycol, tripropylene glycol and diethylene glycol, ketone solvents having 3 to 10 carbon atoms such as acetone and methyl ethyl ketone, higher alcohol solvents having 11 or more carbon atoms such as 1-butanol and 1-octanol, and water. Among these, since the sprayed particles do not remain excessively in the air and a sufficient amount of the harmful microorganism-controlling component adheres uniformly to the ceiling, the upper part of the wall, etc., and an excellent controlling effect against harmful microorganisms can be obtained, a lower alcohol solvent having 2 to 3 carbon atoms, a hydrocarbon solvent, a higher fatty acid ester solvent having 16 to 22 carbon atoms are preferable, and a lower alcohol solvent having 2 to 3 carbon atoms, which also has a bacterial controlling effect, a virus controlling effect, etc., is more preferable. The above solvents may be used singly or in combination of plural kinds.
The specific gravity of the aerosol collagen liquid at 20℃is preferably set to 0.76 to 0.95, more preferably 0.76 to 0.90, and still more preferably 0.76 to 0.88. When the specific gravity of the aerosol stock solution is 0.76 to 0.95 at 20 ℃, a sufficient amount of the harmful microorganism-controlling component after the injection can be uniformly adhered to the ceiling and wall surface in the indoor space. Since harmful microorganisms such as mold and bacteria tend to be generated and propagated in the ceiling, the upper part of the wall surface, and the like, which are often not easily cleaned thoroughly, a sufficient amount of harmful microorganism control components are uniformly adhered to the ceiling, the upper part of the wall surface, and the like, whereby an excellent control effect against harmful microorganisms can be exerted in the indoor space.
In addition to the above components, an insecticidal component, a repellent, a fragrance, a deodorant, a stabilizer, an antistatic agent, an antifoaming agent, an excipient, and the like may be appropriately blended into the aerosol stock solution, as long as the gist of the present invention is not exceeded. Examples of the insecticidal component include transfluthrin, bifluthrin, phenothrin, cyhalothrin, permethrin, cypermethrin, bifenthrin, fenpropathrin, tetramethrin, ethofenprox, imazathrin, allethrin, prallethrin, and pyrethrins such as natural pyrethrin, fluorosilicone, and organic phosphorus compounds such as dichlorvos, and fenitrothion, dinotefuran, and neonicotinoids such as dinotefuran, fipronil, and flubenazol. Examples of the repellent include deet, ethyl butyl levulinate (IR 3535), menthane-3, 8-diol, and hydroxypiperidine (icardin). Examples of the aromatic include aromatic components such as orange oil, lemon oil, lavender oil, peppermint oil, eucalyptus oil, lemon eucalyptus oil, citronella oil, lyme oil, grapefruit oil, jasmine oil, juniper oil, green tea essential oil, peppermint oil, menthol, menthyl acetate, limonene, α -pinene, linalool, geraniol, phenethyl alcohol, amyl cinnamic aldehyde, cumin aldehyde, terpineol, and benzyl acetate, and perfume components containing a combination of green leaf alcohol or green leaf aldehyde called "green leaf volatile (green leaf volatiles)". When chiral carbon-based optical isomers and double bond-based geometric isomers exist, each of them alone or in any combination is also included in the present invention.
The quantitative spray aerosol product for controlling harmful microorganisms of the present invention may also be an aqueous formulation. In this case, the amount of water contained in the aerosol collagen liquid is not particularly limited, but is preferably 5v/v to 80v/v, and a plurality of nonionic surfactants may be added as a solubilizing aid in a range not affecting the spray pattern of the spray particles. Examples of the nonionic surfactant include ethers such as polyoxyethylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, and polyoxyethylene alkylamino ethers, polyethylene glycol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, fatty acid esters such as polyoxyethylene glycerol fatty acid esters, polyoxyethylene styrenated phenols, and polyalkylene alkanolamides of fatty acids.
< propellant >
The propellant used in the quantitative spray aerosol product for controlling harmful microorganisms of the present invention is not particularly limited, and examples thereof include Liquefied Petroleum Gas (LPG) such as propane and butane, liquefied gas (e.g., hydrofluoroolefins such as n-pentane, isopentane, dimethyl ether (DME), HFO1234ze, and the like, and such gases as nitrogen, carbon dioxide, nitrous oxide, compressed air, and the like. The propellant may be used alone or in a mixed state, and since the particles of the propellant do not remain excessively in the air, a sufficient amount of the harmful microorganism-controlling component adheres uniformly to the ceiling, the upper part of the wall surface, etc., and a more excellent controlling effect against the harmful microorganisms can be exerted in the indoor space (particularly in a narrow space), it is preferable that the propellant contains 1 or 2 or more kinds selected from LPG, hydrofluoroolefin, DME, and more preferable that LPG and hydrofluoroolefin be contained. The propellant is preferably used by adjusting the gauge pressure (20 ℃) to 0.10MPa to 0.70 MPa.
In the quantitative spray aerosol product for controlling harmful microorganisms of the present invention, the volume ratio (a/b) of the aerosol-forming liquid (a) to the propellant (b) in the aerosol container is preferably set to 5/95 to 70/30 by volume, more preferably 10/90 to 60/40, still more preferably 20/80 to 55/45, particularly preferably 30/70 to 50/50, from the viewpoint of adhesion of the chemical to a ceiling or an upper part of a wall surface or the like. If the volume ratio (a/b) is within the above range, the particles to be sprayed will not remain excessively in the air when the aerosol product is sprayed into the indoor space, and will reliably reach the ceiling, the upper wall portion, etc., and therefore, a sufficient amount of the harmful microorganism control ingredient can be uniformly adhered to the ceiling, the upper wall portion, etc. Thus, an appropriate control effect against harmful microorganisms can be obtained, and the feeling of irritation to humans can be reduced.
The internal pressure of the aerosol container of the quantitative spray aerosol product for controlling harmful microorganisms of the present invention is preferably set to 0.60MPa or less at 25 ℃, more preferably 0.10MPa to 0.60MPa, still more preferably 0.20MPa to 0.60MPa, and particularly preferably 0.30MPa to 0.55MPa. When the internal pressure is 0.60MPa or less at 25 ℃, a sufficient amount of the harmful microorganism-controlling component can be adhered to the ceiling, the upper part of the wall surface, and the like when the aerosol product is sprayed into the indoor space. The internal pressure of the aerosol container of such an aerosol product can be appropriately adjusted according to the type of propellant, the vapor pressure of the propellant, and the like. The aerosol container may be any pressure-resistant container capable of withstanding the internal pressure of the aerosol container, and examples of the material thereof include metals such as aluminum and iron scale, synthetic resins such as polyethylene terephthalate, and pressure-resistant glass. In addition, when the aerosol container is made of synthetic resin, it may be translucent or transparent. In the present embodiment, the internal pressure of the aerosol container of the quantitative spray aerosol product for controlling harmful microorganisms is measured by the following procedure.
(1) The quantitative spray aerosol product for controlling harmful microorganisms was immersed in a constant temperature water tank at 25.+ -. 0.5 ℃ for 30 minutes.
(2) Then, the quantitative spray aerosol product for controlling harmful microorganisms is placed in an upright state, a stem (stem) of the aerosol container is inserted into an insertion port of a pressure gauge in an airtight manner, and the measured pressure is read to a decimal point and then the second position is obtained.
(3) The above measurement was performed 1 time, and the read value was taken as the internal pressure value without rounding the measured value.
The volume of the aerosol container is not particularly limited, but is preferably 20 mL-500 mL, more preferably 20 mL-250 mL. By setting the volume of the aerosol container within the above range, it is easy to hold with a hand and to perform a spraying operation.
The spraying force of the quantitative spray aerosol product for controlling harmful microorganisms of the present invention is preferably 2.0gf to 40.0gf, more preferably 2.0gf to 35.0gf, and even more preferably 3.0gf to 30.0gf at 25℃at a distance of 15cm from the spraying orifice. When the spraying force is within the above range, a sufficient amount of the harmful microorganism-controlling component uniformly adheres to the ceiling, the upper part of the wall surface, etc. when the aerosol product is sprayed in the indoor space, and an excellent (at least practically sufficient) controlling effect against the harmful microorganism is obtained. Such ejection force can be appropriately adjusted by the composition of the aerosol liquid, the type of the ejection agent, the internal pressure of the aerosol container, the size and shape of the ejection port, and the like. In the present embodiment, the ejection force of the quantitative ejection aerosol product for controlling harmful microorganisms was measured by a digital dynamometer (FGC-0.5, manufactured by japan electric power generation and new co).
In the quantitative spray aerosol product for controlling harmful microorganisms of the present invention, 50% of the spray particles formed when the spray member is operated to spray the aerosol-containing liquid in the aerosol container have a particle size of 17 to 120 μm, preferably 19 to 115 μm, more preferably 23 to 95 μm, and particularly preferably 22 to 81 μm in a cumulative volume distribution at 25 ℃ at a distance of 30cm from the spray orifice. The 50% particle diameter of the ejection particles may be changed in size (that is, may be adjusted) by providing an adjusting mechanism in the ejection member, or the 50% particle diameter of the ejection particles may be set in the above range in advance by the fixed ejection member. When the particle diameter of 50% of the cumulative volume distribution at a distance of 30cm from the spraying opening at 25 ℃ is within the above range, the sprayed particles reach the ceiling, the upper part of the wall surface, etc. of the indoor space where the harmful microorganisms are likely to be generated and propagated when the aerosol product is sprayed in the indoor space, and thereby the harmful microorganism control component is sufficiently and uniformly adhered to the height. As a result, an excellent (at least practically sufficient) control effect against harmful microorganisms can be exerted. The 50% particle diameter in the volume cumulative distribution of the ejected particles can be appropriately adjusted by the composition of the aerosol liquid, the composition of the propellant, the ratio of the propellant, the internal pressure of the aerosol container, the shape of the nozzle, the length of the nozzle, and the like.
In the present invention, the 50% particle diameter in the cumulative volume distribution of the ejected particles means the volume average particle diameter (Dv 50) measured by the particle size distribution measuring device and analyzed by the automatic arithmetic processing device. Specifically, the position of the aerosol product was adjusted at 25 ℃ by using a laser particle size distribution measuring device (SPRAYTEC model STP5321, manufactured by Malvern corporation) so that the distance between the laser beam emitted from the laser light emitting unit and the emission port of the quantitative aerosol product for controlling harmful microorganisms was 30cm and the emitted particles passed through the laser beam perpendicularly. Then, the particle size distribution of the sprayed particles was analyzed by an automatic arithmetic processing device, and the 50% particle size in the cumulative volume distribution of the sprayed particles was obtained.
The quantitative injection aerosol product for controlling harmful microorganisms of the present invention comprises a quantitative injection valve for performing a quantitative injection treatment in an indoor space. The injection capacity of the quantitative injection valve per 1 time is usually set to 0.08 to 3.0mL, preferably 0.2 to 2.0mL, more preferably 0.4 to 1.0mL, still more preferably 0.5 to 1.0mL, and particularly preferably 0.5 to 0.9mL. If the spraying capacity per 1 time is within the above range, the harmful microorganism-controlling component contained in the sprayed particles can be sufficiently and uniformly adhered to the ceiling, the upper part of the wall surface, etc. by operating the spraying member only a predetermined number of times according to the size of the indoor space, and the spray member is suitable for use in the indoor space.
The spray member (spray button, spray lever) is a member attached to the aerosol container via a metering jet valve. An ejection port that ejects aerosol stock solution and an ejection agent extracted from a spray container via a stem hole of a quantitative ejection valve is provided in the ejection member. The nozzle diameter of the spraying member is preferably 0.2 to 3.0mm, more preferably 0.2 to 2.0mm, still more preferably 0.2 to 1.2mm, and particularly preferably 0.5 to 1.2mm. When the diameter of the nozzle is within the above range, the ejection force can be adjusted to an appropriate range without clogging or dripping, and spray particles can be formed satisfactorily. The shape (cross-sectional shape) of the ejection port is not particularly limited, and examples thereof include a polygon such as a circle and a quadrangle, an ellipse, and the like, and preferably a circle. Here, the nozzle diameter refers to the major diameter of an ellipse when the shape of the ejection port is an ellipse, and refers to the diameter of a circumscribed circle of a polygon when the shape of the ejection port is a polygon. In addition, a plurality of ejection openings having an area equal to that of the ejection openings may be provided.
In the injection port of the quantitative injection aerosol product for controlling harmful microorganisms of the present invention, the elevation angle of the injection port with respect to the horizontal plane is preferably set to 0 ° to 60 °. If the elevation angle of the ejection port with respect to the horizontal plane is in the above range, ejection failure is less likely to occur, and the aerosol composition can be stably ejected. The elevation angle of the jet port of the nozzle or the actuator having two jet ports with respect to the horizontal plane is set to be the elevation angle of the perpendicular bisector of the line segment connecting the centers of the jet ports with respect to the horizontal plane. The elevation angle of the injection port with respect to the horizontal plane is determined as follows for the injection port or actuator having 3 or more injection ports. The nozzle or actuator having an injection port at the center of the injection portion of the nozzle or actuator is set to an elevation angle of an orthogonal line passing through the center of the central injection port with respect to a horizontal plane. The nozzle or actuator in which no ejection port is present in the center of the ejection portion of the nozzle or actuator is set to an elevation angle with respect to the horizontal plane of an orthogonal line passing through the center of a circumscribed circle of a polygon connecting the centers of the ejection ports.
In the quantitative spray aerosol product for controlling harmful microorganisms of the present invention, the release amount of the harmful microorganism controlling ingredient into the air is preferably set to 0.01mg/m 3 ～250mg/m 3 More preferably, it is set to 0.025mg/m 3 ～125mg/m 3 . If the release amount of the harmful microorganism control ingredient into the air isIn the above range, an excellent control effect against harmful microorganisms can be exhibited in the indoor space. In the quantitative spray aerosol product for controlling harmful microorganisms of the present invention, the release amount of the harmful microorganism control ingredient into the air can be made 0.01mg/m by 1 spray 3 ～250mg/m 3 The amount of the harmful microorganism-controlling ingredient to be sprayed may be set to 0.01mg/m by 2 or more times of spraying 3 ～250mg/m 3 The amount of the harmful microorganism-controlling component to be sprayed was set 1 time. From the viewpoint of obtaining a more excellent control effect against harmful microorganisms in the indoor space, it is preferable that the release amount of the harmful microorganism control component into the air is set to 0.01mg/m by 2 or more injections 3 ～250mg/m 3 Is set by the mode of (2). The amount of the harmful microorganism-controlling component to be released can be appropriately adjusted within the above-mentioned ranges, for example, by adjusting the composition of the aerosol stock solution, the volume ratio (a/b) of the aerosol stock solution (a) to the propellant (b), and the injection volume per 1 time of the quantitative injection valve.
The quantitative spray aerosol product for controlling harmful microorganisms of the present invention can generally control harmful microorganisms on the upper part of a ceiling or wall surface after 1 application for about 1 week to 2 months. The period during which the harmful microorganisms can be controlled may be less than 1 week, or may be more than 2 months by adjusting the composition of the aerosol collagen solution, the type of the propellant, and the like.
< harmful microorganism >
Examples of the harmful microorganism to be controlled in the present invention include microorganisms such as bacteria, mold, viruses and the like or microorganisms derived from organisms. The quantitative spray aerosol product for controlling harmful microorganisms of the present invention can more effectively control harmful microorganisms such as bacteria and mold, which often have a tendency to be generated and propagated in a ceiling, an upper part of a wall surface, or the like, which is not easily cleaned thoroughly.
[ method for controlling harmful microorganism ]
The harm of the inventionThe microorganism control method is carried out in an indoor space (preferably having a volume of 2.0m 3 ～18.8m 3 Is a small space) for spraying the quantitative spray aerosol product for controlling harmful microorganisms. When the method for controlling harmful microorganisms of the present invention is carried out, a sufficient amount of the harmful microorganism-controlling ingredient uniformly adheres to the ceiling, the upper part of the wall surface, etc. in the indoor space (particularly, a small space), and an excellent controlling effect against harmful microorganisms is exhibited. In the method for controlling harmful microorganisms according to the present invention, it is preferable that the spraying port be directed upward in the indoor space in order to more effectively control harmful microorganisms such as bacteria and mold which often tend to be generated and propagated in the ceiling, the upper part of the wall surface, and the like, which are not always easy to clean thoroughly. Here, the amount of the harmful microorganism-controlling component released into the air is preferably 0.01mg/m in terms of the amount of the harmful microorganism-controlling component sprayed to the air 3 ～250mg/m 3 More preferably, the amount of the harmful microorganism control ingredient released into the air is 0.025mg/m 3 ～125mg/m 3 Is adjusted by means of the (a) and (b). When the amount of the harmful microorganism-controlling component released is within the above range, an excellent controlling effect against harmful microorganisms can be exerted in the indoor space.
In the method for controlling harmful microorganisms of the present invention, the aerosol product is preferably sprayed so that the spray direction angle of the quantitative spray for controlling harmful microorganisms is 0 ° to 60 ° with respect to the horizontal plane, and more preferably is sprayed so as to be 30 ° to 60 °.
Examples
In order to verify the effect of the quantitative spray aerosol product for controlling harmful microorganisms of the present invention, quantitative spray aerosol products for controlling harmful microorganisms (examples 1 to 19) having the characteristic configuration of the present invention were prepared, and (1) experiments for evaluating the ceiling adhesion and diffusion uniformity of harmful microorganism control components were performed. For comparison, a pump spray product (comparative example 1) which is not a quantitative spray aerosol product, and quantitative spray aerosol products (comparative examples 2 to 5) which do not have the characteristic features of the invention were prepared, and the same test was performed. Further, using the quantitative spray aerosol products for controlling harmful microorganisms of examples 1, 2, 4, 6, 10, 11 and 14 to 16, (2) a test for evaluating use in a bathroom was performed. Further, using the quantitative spray aerosol product for controlling harmful microorganisms of examples 1, 4 and 14, (3) a test for evaluating use in a room was performed.
Example 1
Isopropyl methylphenol (IPMP) as a harmful microorganism control ingredient was dissolved in ethanol (40 w/v%) as a solvent to prepare an aerosol stock solution. The quantitative spray aerosol product for controlling harmful microorganisms of example 1 was obtained by pressurizing and filling 12mL of the aerosol stock solution (a) and 18mL of liquefied petroleum gas (b) as a propellant into an aerosol container (pressure-resistant container) having a quantitative spray valve with a spray capacity of 0.4mL for 1 time so that the ratio of the volume ratio (a/b) was 40/60, and attaching a spray member provided with a spray orifice with a nozzle diameter of 0.7 mm. The amount of the harmful microorganism control ingredient sprayed per 1 spray of the quantitative spray aerosol product for controlling harmful microorganisms was 64mg.
Comparative example 1
Isopropyl methylphenol (IPMP) as a harmful microorganism control ingredient was dissolved in ethanol (40 w/v%) as a solvent to prepare 30mL of an aerosol collagen solution. The aerosol collagen liquid was placed in a container having a head of a pump sprayer with a 1-time spray capacity of 0.2mL, to obtain a pump spray product of comparative example 1. The spray amount of the harmful microorganism-controlling ingredient per 1 spray of the pump spray product was 80mg.
Examples 2 to 19 and comparative examples 2 to 5
Various aerosol articles shown in table 1 were prepared following the procedure of example 1. In the quantitative spray aerosol product for controlling harmful microorganisms of example 8 and the quantitative spray aerosol products of comparative examples 3 and 5, aerosol containers having a 1-time spray valve with a spray capacity of 0.2mL were used. In the quantitative spray aerosol products for controlling harmful microorganisms of examples 3 to 5, 7, 10, 12, 13 and 15, aerosol containers each having a 1-time spray valve with a spray capacity of 0.4mL were used. In the quantitative spray aerosol products for controlling harmful microorganisms of example 6, example 11, example 14 and example 16, aerosol containers with 1-time spray valves having a spray capacity of 0.8mL were used. In the quantitative spray aerosol products for controlling harmful microorganisms of example 2, example 9 and examples 17 to 19 and the quantitative spray aerosol products of comparative examples 2 and 4, aerosol containers having a 1-time spray capacity of 1.0mL of the quantitative spray valve were used. As for the injection member connected to the quantitative injection valve, an injection member having a nozzle diameter of 0.7mm was used in the same manner as in example 1 in examples 2 to 16 and comparative examples 2 to 3. In examples 17 to 19, jet members having jet diameters of 0.5mm, 0.9mm and 1.2mm, respectively, were used. In comparative examples 4 and 5, jet members having jet diameters of 0.3mm and 1.6mm, respectively, were used.
< measurement of internal pressure of aerosol Container >
The internal pressure of the aerosol container was measured by the following procedure (the results are shown in table 1).
(1) The quantitative spray aerosol products of examples 1 to 19 and comparative examples 2 to 5 were immersed in a constant temperature water bath at 25.+ -. 0.5 ℃ for 30 minutes.
(2) Next, the respective quantitative aerosol products are set upright, the rod of the aerosol container is inserted into the insertion port of the pressure gauge in an airtight manner, and the measured pressure is read to the second position after the decimal point.
(3) The above measurement was performed 1 time, and the read value was taken as the internal pressure value without rounding the measured value.
< measurement of 50% particle diameter in cumulative volume distribution of ejected particles >
For the quantitative spray aerosol products of examples 1 to 19 and comparative examples 2 to 5, 50% of the particle diameters in the cumulative distribution of the volumes of the spray particles at 25℃were measured. Each aerosol product was allowed to stand at room temperature set at 25℃for 2 to 3 hours, so that the temperature of each aerosol product was kept constant at 25 ℃. In the measurement of 50% particle diameter, the position of the aerosol product was adjusted by using a laser particle size distribution measuring apparatus (SPRAYTEC model STP5321, manufactured by Malvern corporation) at 25 ℃ so that the distance between the laser beam irradiated from the laser light emitting portion to the light receiving portion and the ejection port of each of the quantitative aerosol product was 30cm and the ejected particles passed through the laser beam perpendicularly. The aerosol product was measured during the spraying (trigger mode) by pressing the spray button 1 time, and the particle size distribution of the sprayed particles (average value of the spread data of 0.2 seconds from the start of the measurement) was analyzed by the automatic arithmetic processing device. The measurement was performed 3 times, and the average value was taken as 50% of the particle diameter in the volume cumulative distribution of the ejected particles. In addition, the 50% particle diameter in the cumulative volume distribution of the spray particles was also obtained in the same manner for the pump spray product of comparative example 1 (the results are shown in table 1).
TABLE 1
In Table 1 above, IPMP represents isopropyl methylphenol, compound A represents 1, 4-bis [3,3' - (1-decylpyridinium) methyloxy ] butane dibromide, IPM represents isopropyl myristate, LPG represents liquefied petroleum gas, and HFO 1234ze represents trans-1, 3-tetrafluoropropene.
For examples 1 to 19 and comparative examples 1 to 5, (1) tests for evaluating the ceiling adhesion and diffusion uniformity of the harmful microorganism-controlling component were performed. Further, in the bathroom, using the aerosol products of examples 1, 2, 4, 6, 10, 11 and 14 to 16, (2) a test for confirming the effect of controlling bacteria and mold was performed. Further, using the aerosol products of example 1, example 4 and example 14, a test (3) for confirming the effect of preventing and removing mold was performed in a room.
(1) Evaluation of adhesion to ceiling and diffusion uniformity of harmful microorganism control ingredient
In a closed volume of 3.6m 3 Aluminum foil of 20cm×20cm was provided at 5 positions in total of the center and four corners of the ceiling of the small room (width of 1.2m, depth of 1.6m, height of 1.9 m). The test aerosol product of example 1 was sprayed slightly obliquely upward 4 times from a height of 1.5m from the floor toward 4 corners of the ceiling, standing near the center of the room. After 20 minutes from the spraying, the aluminum foils placed on the ceiling were taken out, and the adhered harmful microorganism control components were washed off with ethanol. When the harmful microorganism control ingredient is IPMP, the adhesion weight of IPMP is analyzed by gas chromatography, and when the harmful microorganism control ingredient is compound a or benzalkonium chloride, the adhesion weight of the harmful microorganism control ingredient is analyzed by measuring absorbance at a wavelength of 264nm using a spectrophotometer (UV-1800, manufactured by shimadzu corporation). In examples 15 and 16 containing 2 harmful microorganism control components, only the adhesion weight of IPMP was analyzed, and the adhesion weights of the compound a and benzalkonium chloride were calculated in proportion to the concentration ratio of IPMP to compound a and the concentration ratio of IPMP to benzalkonium chloride in each aerosol stock solution. The analysis value of the adhesion weight of the obtained harmful microorganism control ingredient was multiplied by (120×160)/(20×20×5) =9.6, and the adhesion weight of the harmful microorganism control ingredient to the whole ceiling was calculated. The ratio of the adhesion weight of the harmful microorganism control ingredient to the total weight of the harmful microorganism control ingredient theoretically sprayed to the total weight of the harmful microorganism control ingredient was determined, and the adhesion of the harmful microorganism control ingredient to the ceiling was evaluated on the basis of the following evaluation, on the order of A, B, C from good to poor. Tests were carried out in the same manner as in examples 2 to 19 and comparative examples 1 to 5 (test results are shown in table 2).
[ evaluation criterion for ceiling adhesion ]
A: the harmful microorganism control component adhered to the ceiling is more than 10%
B: the content of harmful microorganism control component adhered to the ceiling is above 5%
C: the content of harmful microorganism control component adhered to the ceiling is less than 5%
Further, the adhesion weight of the harmful microorganism control component per unit area of each aluminum foil of the ceiling was analyzed, and (maximum adhesion amount)/(minimum adhesion amount) was calculated to evaluate the diffusion uniformity. As for the evaluation results, the uniformity of the diffusion of the harmful microorganism control ingredient was evaluated on the following evaluation criteria, and on the order of A, B, C from good to poor. Tests were carried out in the same manner as in examples 2 to 19 and comparative examples 1 to 5 (test results are shown in Table 2).
[ evaluation criterion for diffusion uniformity ]
A: (maximum adhesion amount)/(minimum adhesion amount). Ltoreq.100
B:100< (maximum adhesion amount)/(minimum adhesion amount) < 1000
C:1000< (maximum adhesion amount)/(minimum adhesion amount)
TABLE 2
It is understood from tables 1 and 2 that the quantitative spray aerosol products for controlling harmful microorganisms of examples 1 to 19, in which 50% of the cumulative volume distribution at a distance of 30cm from the spray orifice at 25℃had been adjusted to 17 μm to 120 μm, were excellent as a whole in terms of the ceiling adhesion and the adhesion uniformity, compared with the pump spray products of comparative example 1 and the quantitative spray aerosol products of comparative examples 2 to 5, in which 50% of the cumulative volume distribution at a distance of 30cm from the spray orifice at 25℃had been adjusted to a distance of 17 μm to 120 μm.
(2) Confirmation of control effect of bacteria and mold in bathroom
Test example 1
At a volume of 3.6m 3 A quantitative jet air-soluble solution for controlling harmful microorganisms of example 1 was set in a unitary bathroom (unit base, japanese, U.S. Pat. No.: in width of 1.2m, depth of 1.6m, and height of 1.9 m) of a size standing near the center of the unitary bathroomThe glue product was sprayed 1 (4 total) times from a height of 1.5m from the floor to each of the 4 corners of the ceiling. In this case, the release amount of the harmful microorganism-controlling ingredient was 71mg/m 3 . Then, after 14 days, it was confirmed that no pink stick-slip (bacteria) and no black mold (mold) were generated in the entire bathroom. That is, the composition can prevent and remove powdery slimes (bacteria) and black mold (mildew) for 14 days or more.
Test example 2
At a volume of 3.6m 3 (width of 1.2m, depth of 1.6m, and height of 1.9 m), the quantitative spray aerosol product for controlling harmful microorganisms of example 2 was sprayed slightly obliquely upward from a height of 1.5m from the floor to the ceiling for 2 times (the direction of each spray was opposite directions) while standing near the center of the entire bathroom. In this case, the release amount of the harmful microorganism-controlling ingredient was 0.83mg/m 3 . Then, after 14 days, it was confirmed that no pink stick-slip (bacteria) and no black mold (mold) were generated in the bathroom. That is, the composition can prevent and remove powdery slimes (bacteria) and black mold (mildew) for 14 days or more.
Test example 3
At a volume of 3.6m 3 (the total bath room was 1.2m wide, 1.6m deep and 1.9m high), and the quantitative spray aerosol product for controlling harmful microorganisms of example 4 was sprayed 1 time (total of 4 times) from the height of 1.5m from the floor to 4 corners of the ceiling while standing near the center of the total bath room. In this case, the release amount of the harmful microorganism-controlling ingredient was 2.22mg/m 3 . Then, after 14 days, it was confirmed that no pink stick-slip (bacteria) and no black mold (mold) were generated in the entire bathroom. That is, the composition can prevent and remove powdery slimes (bacteria) and black mold (mildew) for 14 days or more.
Test example 4
At a volume of 3.6m 3 (width of 1.2m, depth of 1.6m, height of 1.9 m) in a large-sized whole bathroom, standing near the center of the whole bathroom, and spraying the quantitative spray aerosol product for controlling harmful microorganisms of example 6 1 (total of 4 times) from the height of 1.5m from the floor to 4 corners of the ceiling 1 time each . In this case, the release amount of the harmful microorganism-controlling ingredient was 40mg/m 3 . Then, after 14 days, it was confirmed that no pink stick-slip (bacteria) and no black mold (mold) were generated in the entire bathroom. That is, the composition can prevent and remove powdery slimes (bacteria) and black mold (mildew) for 14 days or more.
Test example 5
At a volume of 3.6m 3 (the total bath room was 1.2m wide, 1.6m deep and 1.9m high), and the quantitative spray aerosol product for controlling harmful microorganisms of example 10 was sprayed 1 time (total of 4 times) from the height of 1.5m from the floor to 4 corners of the ceiling while standing near the center of the total bath room. In this case, the release amount of the harmful microorganism-controlling ingredient was 27mg/m 3 . Then, after 14 days, it was confirmed that no pink stick-slip (bacteria) and no black mold (mold) were generated in the entire bathroom. That is, the composition can prevent and remove powdery slimes (bacteria) and black mold (mildew) for 14 days or more.
Test example 6
At a volume of 3.6m 3 (the total bath room was 1.2m wide, 1.6m deep and 1.9m high), and the quantitative spray aerosol product for controlling harmful microorganisms of example 11 was sprayed 1 time (total of 4 times) from the height of 1.5m from the floor to 4 corners of the ceiling while standing near the center of the total bath room. In this case, the release amount of the harmful microorganism-controlling ingredient was 2.22mg/m 3 . Then, after 14 days, it was confirmed that no pink stick-slip (bacteria) and no black mold (mold) were generated in the entire bathroom. That is, the composition can prevent and remove powdery slimes (bacteria) and black mold (mildew) for 14 days or more.
Test example 7
At a volume of 3.6m 3 (width of 1.2m, depth of 1.6m, and height of 1.9 m), the quantitative spray aerosol product for controlling harmful microorganisms of example 14 was sprayed slightly obliquely upward from a height of 1.5m from the floor to the ceiling for 2 times (the direction of each spray was opposite directions) while standing near the center of the entire bathroom. In this case, the release amount of the harmful microorganism-controlling ingredient was 1.11mg/m 3 . Then, after 14 days, it was confirmed that no pink stick-slip (bacteria) and no black mold (mold) were generated in the bathroom. That is, the composition can prevent and remove powdery slimes (bacteria) and black mold (mildew) for 14 days or more.
Test example 8
At a volume of 3.6m 3 (the total bath room of a size of 1.2m in width, 1.6m in depth and 1.9m in height) was set up near the center of the total bath room, and the quantitative spray aerosol product for controlling harmful microorganisms of example 15 was sprayed 1 time (total of 4 times) from the height of 1.5m from the floor to 4 corners of the ceiling. In this case, the release amount of the harmful microorganism-controlling ingredient was 29mg/m 3 . Then, after 14 days, it was confirmed that no pink stick-slip (bacteria) and no black mold (mold) were generated in the entire bathroom. That is, the composition can prevent and remove powdery slimes (bacteria) and black mold (mildew) for 14 days or more.
Test example 9
At a volume of 3.6m 3 (the total bath room was 1.2m wide, 1.6m deep and 1.9m high), and the quantitative spray aerosol product for controlling harmful microorganisms of example 16 was sprayed 1 time (total of 4 times) from the height of 1.5m from the floor to 4 corners of the ceiling while standing near the center of the total bath room. In this case, the release amount of the harmful microorganism-controlling ingredient was 41mg/m 3 . Then, after 14 days, it was confirmed that no pink stick-slip (bacteria) and no black mold (mold) were generated in the entire bathroom. That is, the composition can prevent and remove powdery slimes (bacteria) and black mold (mildew) for 14 days or more.
(3) Confirmation of mold control Effect in Room
Test example 10
At a volume of 25m 3 Is equivalent to a room of 6 tatami (10 m in area) 2 ) The quantitative spray aerosol product for controlling harmful microorganisms of example 1 was sprayed slightly obliquely upward from a height of 1.5m from the floor to the ceiling 4 times while standing near the center of the room. In this case, the release amount of the harmful microorganism-controlling ingredient was 10mg/m 3 . Then, confirmation was performed after 7 days, and the result was in a roomNo black mold (mildew) was produced therein. That is, it is possible to control black mold (mildew) for 7 days or more.
Test example 11
At a volume of 25m 3 Is equivalent to a room of 6 tatami (10 m in area) 2 ) The quantitative spray aerosol product for controlling harmful microorganisms of example 4 was sprayed slightly obliquely upward from a height of 1.5m from the floor to the ceiling 4 times while standing near the center of the room. In this case, the release amount of the harmful microorganism-controlling ingredient was 0.32mg/m 3 . Then, after 7 days, it was confirmed that no black mold (mildew) was generated in the room. That is, it is possible to control black mold (mildew) for 7 days or more.
Test example 12
At a volume of 25m 3 Is equivalent to a room of 6 tatami (10 m in area) 2 ) The quantitative spray aerosol product for controlling harmful microorganisms of example 14 was sprayed slightly obliquely upward from a height of 1.5m from the floor to the ceiling for 2 times (the direction of each spray was opposite) while standing near the center of the room. In this case, the release amount of the harmful microorganism-controlling ingredient was 0.16mg/m 3 . Then, after 7 days, it was confirmed that no black mold (mildew) was generated in the room. That is, it is possible to control black mold (mildew) for 7 days or more.
Industrial applicability
The quantitative spray aerosol product for controlling harmful microorganisms and the method for controlling harmful microorganisms according to the present invention can be used for the purpose of controlling harmful microorganisms in indoor spaces, particularly in small spaces such as bathrooms and toilets.
Claims (8)
1. A quantitative-injection aerosol product for controlling harmful microorganisms in an indoor space, comprising:
an aerosol container provided with a quantitative injection valve in which an aerosol stock solution containing a harmful microorganism control component and an injection agent are enclosed, and
an injection member provided with an injection port connected to the quantitative injection valve,
the particle diameter of 50% of the cumulative volume distribution of the spray particles formed when the aerosol collagen liquid in the aerosol container is sprayed by operating the spraying means is adjusted to 17-120 [ mu ] m at 25 ℃ at a distance of 30cm from the spraying port.
2. The quantitative spray aerosol product for controlling harmful microorganisms according to claim 1, wherein the spray capacity of the quantitative spray valve for 1 time is 0.08 to 3.0mL.
3. The quantitative spray aerosol product for controlling harmful microorganisms according to claim 1 or 2, wherein a volume ratio a/b of the aerosol collagen liquid a and the spray agent b enclosed in the aerosol container is 5/95 to 70/30.
4. The quantitative spray aerosol product for controlling harmful microorganisms according to any one of claims 1 to 3, wherein the volume of the indoor space is 2.0m 3 ～25.0m 3 。
5. The quantitative spray aerosol product for controlling harmful microorganisms according to any one of claims 1 to 4, wherein the release amount of the harmful microorganism control ingredient is set to 0.01mg/m 3 ～250mg/m 3 。
6. A method for controlling harmful microorganisms, wherein the quantitative spray aerosol product for controlling harmful microorganisms according to any one of claims 1 to 5 is used for spray treatment in an indoor space.
7. The method for controlling harmful microorganisms according to claim 6, wherein the volume of the indoor space is 2.0m 3 ～25.0m 3 。
8. The pest control method according to claim 6 or 7, wherein the pest microorganism is controlledThe release amount of the ingredients was 0.01mg/m 3 ～250mg/m 3 In the above method, the quantitative spray aerosol product for controlling harmful microorganisms is sprayed.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021-147248 | 2021-09-10 | ||
| JP2021147248 | 2021-09-10 | ||
| PCT/JP2022/031210 WO2023037840A1 (en) | 2021-09-10 | 2022-08-18 | Fixed-amount spray aerosol product for controlling harmful microorganisms and method for controlling harmful microorganisms using same |
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| CN117881287A true CN117881287A (en) | 2024-04-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202280058149.8A Pending CN117881287A (en) | 2021-09-10 | 2022-08-18 | Quantitative spray aerosol product for controlling harmful microorganism and method for controlling harmful microorganism using the same |
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| JP (1) | JPWO2023037840A1 (en) |
| CN (1) | CN117881287A (en) |
| WO (1) | WO2023037840A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2003342103A (en) * | 2002-05-29 | 2003-12-03 | Sakura Color Prod Corp | Mildewproofing agent spray |
| JP5517496B2 (en) * | 2009-06-05 | 2014-06-11 | 大日本除蟲菊株式会社 | Pest control method |
| JP6034658B2 (en) * | 2012-10-29 | 2016-11-30 | 大日本除蟲菊株式会社 | Clothing pest control method |
| CN106163274B (en) * | 2014-04-18 | 2019-03-08 | 大日本除虫菊株式会社 | Mosquito class is prevented and kill off with aerosol and mosquito class the method for control |
| JP6539407B2 (en) * | 2016-03-31 | 2019-07-03 | アース製薬株式会社 | Injection products and methods |
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- 2022-08-18 WO PCT/JP2022/031210 patent/WO2023037840A1/en active Application Filing
- 2022-08-18 CN CN202280058149.8A patent/CN117881287A/en active Pending
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| WO2023037840A1 (en) | 2023-03-16 |
| JPWO2023037840A1 (en) | 2023-03-16 |
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