CN117859756A - Fluoxapirin-containing bactericidal composition - Google Patents
Fluoxapirin-containing bactericidal composition Download PDFInfo
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- CN117859756A CN117859756A CN202410007511.XA CN202410007511A CN117859756A CN 117859756 A CN117859756 A CN 117859756A CN 202410007511 A CN202410007511 A CN 202410007511A CN 117859756 A CN117859756 A CN 117859756A
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- benziothiazolinone
- fluoxapirin
- bactericidal composition
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Abstract
The invention discloses a bactericidal composition containing Fluoxapirin, which comprises the active ingredients of Fluoxapirin and benziothiazolinone in a mass ratio of 50:1 to 1:50, wherein the mass percentage of the active ingredients in the composition is 5-80%. The composition can be prepared into dispersible oil suspending agents, wettable powder, water dispersible granules and other dosage forms. The application sites of the bactericidal composition are farmlands, orchards and the like, and the bactericidal composition is used for preventing and controlling various oomycete diseases such as downy mildew, late blight and the like on crops such as vegetables, fruit trees, flowers and the like.
Description
Technical Field
The invention relates to a bactericidal composition containing Fluoxapoprolin, belonging to the field of agricultural bactericides.
Background
Cucumber downy mildew, commonly known as "horse race dry" and "dry leaf", can be damaged by adult plants in seedling stage, mainly harmful leaves and stems, and less damage to tendrils and pedicel. The pathogenic agent of cucumber downy mildew is pseudoperonospora cubensis (Pseudoperonospora cubensis) of the genus pseudoperonospora of the subgenera, and the sporangium of the pathogenic agent is spread by air flow and rainwater. Cucumber downy mildew is the most common and serious disease occurring in cucumber cultivation. The disease is strong, the disease is serious, the transmission is quick, if the disease is not prevented in time, destructive loss is caused to the cucumber.
The tomato late blight is one of important diseases on tomatoes, can occur in protected areas and open fields, and is seriously damaged in continuous overcast and rainy weather for a plurality of years. When the disease is serious, stem rot, plant wilting and fruit browning are caused, and the yield is affected.
In the prevention and treatment of cucumber downy mildew and tomato late blight, dimethomorph, metalaxyl and some protective agents are mainly relied on. The medicines have different degrees of drug resistance after long-term use, and the prevention and treatment effects are reduced. Meanwhile, the pesticide residue is increased by using a large amount of medicaments, the food safety is jeopardized, and the environmental pollution is aggravated, so that the bactericidal composition containing the Fluoxapoprolin is provided.
Disclosure of Invention
The invention aims to provide a novel bactericidal composition with small resistance risk, low cost, good efficacy and long lasting period.
A bactericidal composition containing Fluoxapirin contains Fluoxapirin and benziothiazolinone as effective components.
The mass ratio of Fluoxapirin to benziothiazolinone is preferably 50:1-1:50.
The mass ratio of Fluoxapirin to benziothiazolinone is preferably 30:1-1:30.
Preferably, as a preferred aspect of the present invention, the composition comprises 5 to 80% by mass of active ingredient.
Preferably, as a preferable mode of the invention, the composition can be prepared into any dosage form, and better dosage forms include dispersible oil-dispersible oil suspending agent, wettable powder and water dispersible granule.
Preferably, as a preferred aspect of the invention, the composition may be provided in the form of a finished formulation, i.e. the materials of the composition have been mixed; the components of the composition may also be provided in a single formulation, which is mixed directly in the tank (canister) prior to use.
Preferably, as a preferred aspect of the present invention, the bactericidal composition is used for controlling cucumber downy mildew and tomato late blight.
The beneficial effects are that: firstly, the synergistic effect of the composition is obvious, and the efficacy is greatly improved; secondly, the field dosage is reduced, the production and use cost is reduced, and the pesticide residue and the environmental pollution are reduced; and thirdly, the composition consists of active ingredients with different action mechanisms, and the action sites are increased, so that the composition is beneficial to overcoming and delaying the generation of drug resistance of pathogenic bacteria.
Through a large number of indoor bioassay and field efficacy tests, the inventor surprisingly finds that after the Fluoxapoprolin and the benziothiazolinone are mixed according to a certain proportion, the Fluoxapoprolin and the benziothiazolinone have remarkable synergism on diseases such as cucumber downy mildew and tomato late blight.
The benziothiazolinone (benzodiazinone) has formula C 7 H 5 SON, chemical name 1,2 benzisothiazolin-3-one is a novel broad-spectrum bactericide, and has prevention and treatment effects on fungal diseases. The composition is mainly used for preventing and treating cucumber downy mildew, pear scab, apple scab, citrus anthracnose, grape anthracnose and the like, and has special effects on various bacterial and fungal diseases.
Mechanism of action of fluxapoprolin: the cholesterol metabolism is influenced by inhibiting a novel acting target oxidized cholesterol binding protein (oxysterol binding protein, abbreviated as OSBP), so that the composition of cell membranes is influenced, and CHS1 and FKS2 can also be acted on to influence the composition of cell walls. At very low concentrations at multiple stages of the asexual life cycle of the pathogen. On the one hand it is capable of inhibiting zoospore release and preventing zoospores and sporangia from germinating to produce protective activity; on the other hand, it can prevent hyphal growth in the host plant before visible lesions occur, thereby achieving therapeutic effects.
Mechanism of action of benziothiazolinone: 1. destroying the germ cell nucleus structure to make the germ cell nucleus lose heart parts and die in failure; 2. interfere with the metabolism of germ cells, which causes physiological disturbance and finally causes death. The benziothiazolinone can thoroughly kill germs, so that the ideal effect of eradicating diseases is achieved.
In summary, fluoxapirin has different mechanisms and sites of action from benziothiazolinone, the former interferes with the metabolism of cholesterol compounds and consequently with the composition of cell membranes, and the latter mainly destroys the nuclear structure of pathogenic bacteria and interferes with the metabolism of pathogenic bacteria cells. The two components are compounded to prevent and treat plant diseases, have the effects of reducing and enhancing the efficiency, protect the ecological environment, simultaneously avoid the plant pathogenic bacteria from generating drug resistance to a single medicament, delay the generation speed of the drug resistance and prolong the service life of the medicament. And Fluoxapoprolin and benziothiazolinone are compounded, so that no related report is yet made at home and abroad.
The inventor carries out quantitative analysis and research on the combined action of the composition to form the technical scheme of the invention, namely: a bactericidal composition containing Fluoxapirin, wherein the mass ratio of Fluoxapirin to benziothiazolinone in the composition is 50:1-1:50, and the preferred mass ratio of Fluoxapirin to benziothiazolinone is 30:1-1:30. The total mass percentage of the active components in the composition is 5-80%.
The composition can be prepared into any dosage form suitable for agriculture by a known method, and better dosage forms include dispersible oil, dispersible oil suspending agent, wettable powder, water dispersible granules and the like. These formulations can be prepared by customary methods, for example by mixing the active substances with liquid solvents and/or solid carriers, with the addition of surfactants such as emulsifiers, dispersants, stabilizers, wetting agents, and also binders, defoamers, oxidants, dyes, etc. Including but not limited to the specific ingredients listed in the following formulation examples.
For dispersible oil suspending agents, dispersants such as one or more of polycarboxylates, lignosulfonates such as sodium lignosulfonate, alkyl naphthalene sulfonates; emulsifying agents such as one or more of Nongru 700# (common name alkylphenol formaldehyde resin polyoxyethylene ether), dibutyl sodium naphthalene sulfonate formaldehyde condensate, nongru 2201#, span-60# (common name sorbitan monostearate), nongru 1601# (common name triphenyl ethylphenol polyoxypropylene polyoxyethylene block polymer), TERSPERSE 4894 (2500); wetting agents such as one or more of alkylphenol ethoxylate formaldehyde condensate phosphates, tea seed cake powder, alkylphenol ethoxylate phosphate, phenethyl phenol ethoxylate phosphate, alkyl sulfate, alkyl sulfonate, naphthalene sulfonate; thickeners such as one or more of xanthan gum, polyvinyl alcohol, bentonite; preservatives such as one or more of formaldehyde, benzoic acid, sodium benzoate; defoaming agents such as silicone-based defoaming agents; an antifreezing agent such as one or more of ethylene glycol, propylene glycol, glycerol, urea, and inorganic salts such as sodium chloride.
For water dispersible granules, dispersants such as one or more of polycarboxylate, lignosulfonate, NNO4, alkyl naphthalene sulfonate; wetting agents such as one or more of nonylphenol polyoxyethylene ether, polyoxyethylene alcohol, alkyl sulfate, alkyl sulfonate, naphthalene sulfonate; disintegrants such as one or more of ammonium sulfate, urea, sucrose, and glucose; binders such as one or more of diatomaceous earth, corn starch, PVA, carboxymethyl (ethyl) cellulose; fillers such as one or more of diatomaceous earth, calcium bicarbonate, kaolin, white carbon black, talc, and clay.
For wettable powders, dispersants such as one or more of polycarboxylates, lignosulfonates, alkyl naphthalene sulfonates; wetting agents such as one or more of alkyl sulphates, alkyl sulphonates, naphthalene sulphonates; fillers such as one or more of ammonium sulfate, urea, sucrose, glucose, diatomaceous earth, kaolin, white carbon, light calcium, talc, attapulgite, and china clay.
The compositions of the present invention may be provided in the form of a finished formulation, i.e. the materials of the composition have been mixed; the components of the composition may also be provided in a single formulation, which is mixed directly in the tank (canister) prior to use. The concentrates of the present invention are typically mixed with water to give the desired concentration of active substance.
The composition of the invention can be used for preventing and treating important diseases caused by oomycetes, and is especially suitable for preventing and treating downy mildew and epidemic diseases. The application place of the composition of the invention is farmlands, orchards and the like.
The compositions of the invention may also be used in combination with other compounds having herbicidal, insecticidal or fungicidal properties, in particular protective fungicides, and also with nematicides, protectants, growth regulators, plant nutrients or soil conditioners.
The invention also includes a method of killing fungi in situ by applying the compositions of the invention to the crop and/or fruit and the locus where it is growing or stored, either before or after the crop and/or fruit feel disorder. Can be applied by conventional methods, such as pouring, spraying, atomizing, dusting, spreading. The application amount of the invention varies with weather conditions or crop conditions. The duration of the protective effect is generally related to the content of the individual compounds in the composition, and is related to external factors, such as the climate, but the influence of the climate can be slowed down by using suitable dosage forms.
Detailed Description
After mixing different pesticide active ingredients, three types of action are generally shown: additive action, synergistic action and antagonistic action. However, the specific effect cannot be predicted, and only a large number of experiments can be performed. The compound synergistic formula has the advantages of obviously improving the actual control effect and reducing the use amount of pesticides, thereby greatly delaying the generation speed of pathogen resistance, and being an important means for scientifically controlling diseases.
The inventors have conducted a number of indoor bioassay tests and field efficacy tests and found that the combination of fluxapoprolin and benziothiazolinone has a significant synergistic effect on the cucumber downy mildew and tomato late blight, not just a simple addition of the two agents (see bioassay examples 1,2 for details).
Bioassay example 1: indoor virulence determination of fluxapoprolin and benziothiazolinone compounded cucumber downy mildew (Pseudoperonospora cubensis)
The experiment was carried out using a potting method. Two cucumber seedlings with the same growth vigor in the true leaf period are selected, 5 pots of cucumber seedlings to be tested are selected for each treatment, and numbering is carried out for standby. Spray with a Potter spray tower at 50PSI pressure, 5mL per pot. 5 concentration gradients were set for each agent to apply an equal amount of fresh water as a blank. After 24h of medicament treatment, spraying and inoculating the cucumber downy mildew sporangium suspension, wherein the preparation process of the sporangium suspension is as follows: collecting cucumber leaf with downy mildew, dipping with brush pen, washing with distilled water at 10deg.C to obtain sporangium with concentration of 3×10 5 individual/mL sporangia suspension. Culturing cucumber seedlings in a climatic chamber (relative humidity 100%, temperature 15-20deg.C) after inoculation, maintaining the temperature 15-24deg.C after 24 hr, inducing moisture with relative humidity about 90%, and investigation and record of disease condition after 10d, and calculating disease index and control effect.
Cucumber downy mildew classification criteria:
level 0: the leaf has no disease spots;
stage 1: the area of the disease spots accounts for less than 5% of the whole blade area;
3 stages: the area of the disease spots accounts for 6-10% of the whole leaf area;
5 stages: the area of the lesion accounts for 11-25% of the whole leaf area;
7 stages: the area of the disease spots accounts for 26-50% of the whole leaf area;
stage 9: the area of the disease spots accounts for more than 50% of the whole blade area.
Calculation of the concentration EC in inhibition by least squares 50 According to Sun YunThe Pei method calculates co-toxicity coefficient (CTC).
Measured virulence index (ATI) = (standard agent EC 50 Test agent EC 50 )×100
Theoretical Toxicity Index (TTI) =a agent toxicity index x percentage of agent a+b agent toxicity index x percentage of agent B in the mixture
Co-toxicity coefficient (CTC) = [ actual drug susceptibility index (ATI)/theoretical drug susceptibility index (TTI) ] x 100.
CTC is less than or equal to 80 and is antagonistic, CTC is less than 80 and is less than 120 and is additive, CTC is more than or equal to 120 and is synergistic.
As shown in the results of Table 1, the co-toxicity coefficient of the Fluoxapirin and the benziothiazolinone is above 120 when the ratio is 50:1-1:50, and the co-toxicity coefficient of the Fluoxapirin and the benziothiazolinone is above 170 when the ratio is 30:1-1:30.
TABLE 1 Living test results (indoor) of Fluoxapirin and Thioxazin compounded against Peronospora Cucumidis Sativi
Bioassay example 2: indoor virulence determination of Fluoxapirin and benziothiazolinone compounded tomato late blight bacteria (Phytophthora infestans)
The mycelium growth rate method was used to determine the drug virulence (kidney bean containing medium). Co-toxicity coefficient evaluation was as in bioassay example 1.
As shown in the results of Table 2, the co-toxicity coefficient of the Fluoxapirin and the benziothiazolinone is above 120 when the ratio is 50:1-1:50, and the co-toxicity coefficient of the Fluoxapirin and the benziothiazolinone is above 170 when the ratio is 30:1-1:30.
TABLE 2 Living test results (indoor) of Fluoxapirin and benziothiazolinone combination against tomato late blight bacteria
The invention is further illustrated below with reference to specific examples, but the invention is by no means limited to these examples. The following examples are given for the purpose of illustrating the invention only and are not to be construed as limiting the scope of the invention. It should be noted that any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
The percentage content in all the preparation proportions is mass percentage.
Examples of dispersible oil suspensions
The dispersible oil suspending agent is prepared by uniformly mixing the active ingredients, the dispersing agent, the wetting agent, the thickening agent, the anti-freezing agent, the oil base and other components according to the formula proportion, and grinding or shearing at high speed.
Example 1:31% Fluoxapirolin-benziothiazolinone dispersible oil suspension
Fluoxapoprolin 30%, benziothiazolinone 1%, sodium methylnaphthalene sulfonate formaldehyde condensate (dispersant) 10%, sodium dodecyl sulfate (wetting agent) 3%, xanthan gum (thickener) 2%, bentonite (thickener) 1%, glycerol (antifreeze) 5%, soybean oil up to 100%.
Example 2:31% Fluoxapirolin-benziothiazolinone dispersible oil suspension
1% of Fluoxapoprolin, 30% of benziothiazolinone, 10% of polycarboxylate (dispersing agent), 3% of tea seed cake powder (wetting agent), 2% of polyvinyl alcohol (thickening agent), 1% of bentonite (thickening agent), 5% of ethylene glycol (antifreeze agent) and the balance of turpentine to 100%.
EXAMPLE 3 5% Fluoxapoprolin-benziothiazolinone dispersible oil suspension
Fluoxapoproline 2.5%, benziothiazolinone 2.5%, sodium methylnaphthalene sulfonate formaldehyde condensate (dispersant) 10%, sodium dodecyl sulfate (wetting agent) 3%, xanthan gum (thickener) 2%, bentonite (thickener) 1%, urea (antifreeze) 5%, soybean oil up to 100%.
Example 4:16% Fluoxapirolin-benziothiazolinone dispersible oil suspension
15% of Fluoxapoprolin, 1% of benziothiazolinone, 10% of polycarboxylate (dispersing agent), 3% of tea seed cake powder (wetting agent), 2% of polyvinyl alcohol (thickening agent), 1% of bentonite (thickening agent), 5% of propylene glycol (antifreeze agent) and the balance of turpentine to 100%.
Example of wettable powder
The pesticide active components, the auxiliary agent and the filler are mixed according to a certain proportion, crushed by air flow and mixed to prepare the wettable powder. The main equipment comprises: a mixer and an air flow pulverizer.
Example 5:80% Fluoxapirolin-benziothiazolinone wettable powder
50% of Fluoxapoprolin, 30% of benziothiazolinone, 2% of sodium dodecyl sulfate (wetting agent), 3% of sodium lignin sulfonate (dispersing agent), 10% of white carbon black (filler) and the balance of kaolin to 100%.
Example 6:51% Fluoxapirolin-benziothiazolinone wettable powder
50% of Fluoxapoprolin, 1% of benziothiazolinone, 3% of alkyl sulfate (wetting agent), 3% of polycarboxylate (dispersing agent), 11% of white carbon black (filler) and the balance of bentonite to 100%.
Example 7:16% Fluoxapirolin-benziothiazolinone wettable powder
Fluoxapoprolin 1%, benziothiazolinone 15%, alkyl sulfonate (wetting agent) 3%, sodium lignin sulfonate (dispersing agent) 3%, white carbon black (filler) 11%, and clay to 100%.
Water dispersible granule
According to the formula proportion, the raw materials, the powdery carrier, the wetting and spreading agent, the adhesive and the like are mixed and crushed, then water is added for kneading, and the mixture is added into a granulator with a screen mesh with certain specification for granulation. And then drying and sieving (according to the screen range) to obtain the granular product.
Example 8:51% Fluoxapoprolin-benziothiazolinone water dispersible granule
Fluoxapirin 1%, benziothiazolinone 50%, polycarboxylate (dispersant) 5%, sodium lignin sulfonate (dispersant) 7%, sodium dodecyl sulfate (wetting agent) 2%, ammonium sulfate (disintegrant) 5%, light calcium carbonate up to 100%.
Example 9:40% Fluoxapoprolin-benziothiazolinone water dispersible granule
20% of Fluoxapirolin, 20% of benziothiazolinone, 5% of sodium alkyl naphthalene sulfonate (dispersing agent), 7% of sodium lignin sulfonate (dispersing agent), 2% of sodium dodecyl sulfate (wetting agent), 5% of urea (disintegrating agent) and the balance of light calcium carbonate to 100%.
Field application example 1: field efficacy test of Fluoxapirolin and benziothiazolinone compounding on cucumber downy mildew
The test site was Guangdong Zhaoqing. Selecting a land block with serious perennial occurrence of cucumber downy mildew. The field test method and the result investigation are carried out according to the field efficacy test criterion GB/T17980.26-2000 for controlling cucumber downy mildew by the bactericide. The test agents and amounts are shown in Table 3, and are repeated for 4 cells per treatment, with each cell area being 20 square meters.
The first application is carried out at the initial stage of disease occurrence, the whole plant is sprayed uniformly until the leaf drops, and the clear water treatment is used as a blank control. A second dose was administered 7 days later. The onset of cucumber downy mildew was investigated before the first and 7 days after the second. Five samples were taken per cell, 5 plants were investigated per spot, and all leaves were investigated per plant and classified as a percentage of the lesion area over the whole leaf area. Calculating the disease index and the prevention and treatment effect of each treatment.
Grading standard:
level 0: no disease spots;
stage 1: the area of the disease spots accounts for less than 5% of the whole leaf area;
3 stages: the area of the lesion accounts for 6% -15% of the whole leaf area;
5 stages: the area of the lesion accounts for 16% -25% of the whole leaf area;
7 stages: the area of the lesion accounts for 26% -50% of the whole leaf area;
stage 9: the area of the disease spots accounts for more than 50% of the whole leaf area.
The drug effect calculation method comprises the following steps:
as can be seen from table 3: the control effects of each single agent of Fluoxapirin and benziothiazolinone on cucumber downy mildew are respectively 76.9% and 72.4%, while the control effects of the bactericidal composition in the embodiment of the invention are obviously improved, the minimum control effect is 88.3%, and the maximum control effect is 92.8%. The field test results fully show that after being compounded, the Fluoxapirolin and the benziothiazolinone have remarkable synergistic effect on cucumber downy mildew, and the control effect is greatly improved under the condition of reducing the consumption of active ingredients per mu. Therefore, the composition has the beneficial effects of reducing cost, delaying resistance, and reducing application times and pesticide residues.
TABLE 3 field test results of Fluoxapirin and benziothiazolinone combination on cucumber downy mildew
Field application example 2: field efficacy test of Fluoxapirin and benziothiazolinone compounding on tomato late blight
The test site was shandongtaian. Field test method and result investigation according to field efficacy test criterion GB/T17980.31-2000 for controlling tomato late blight by bactericide
As can be seen from table 4: the single doses of Fluoxapirin and benziothiazolinone have the control effects on tomato late blight of 77.9% and 75.1%, respectively, and the sterilization composition of the embodiment of the invention has obviously improved control effects, the minimum control effect is 88.3%, and the maximum control effect is 93.0%. The field test results fully show that after being compounded, the Fluoxapirin and the benziothiazolinone have remarkable synergistic effect on tomato late blight, and the control effect is greatly improved under the condition of reducing the consumption of active ingredients per mu. Therefore, the composition has the beneficial effects of reducing cost, delaying resistance, and reducing application times and pesticide residues.
TABLE 4 field test results of Fluoxapirin and benziothiazolinone combination on tomato late blight
Claims (7)
1. A bactericidal composition containing fluxapprolin, which is characterized in that: the effective components are Fluoxapirolin and benziothiazolinone.
2. The bactericidal composition of claim 1 wherein: the mass ratio of Fluoxapirin to benziothiazolinone is preferably 50:1-1:50.
3. The bactericidal composition of claim 2 wherein: the mass ratio of Fluoxapirin to benziothiazolinone is preferably 30:1-1:30.
4. A bactericidal composition according to any of claims 1-3, characterized in that: the mass percentage of the active components in the composition is 5-80%.
5. The bactericidal composition of claim 1 wherein: the composition can be prepared into any dosage form, and better dosage forms comprise dispersible oil and dispersible oil suspending agent, wettable powder and water dispersible granule.
6. The bactericidal composition of claim 1 wherein: the composition may be provided in the form of a finished formulation, i.e. the materials of the composition have been mixed; the components of the composition may also be provided in a single formulation, which is mixed directly in the tank (canister) prior to use.
7. The bactericidal composition as claimed in claim 1 for controlling cucumber downy mildew and tomato late blight.
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