CN117839070A

CN117839070A - Tumor electric field treatment system, tumor treatment equipment and electrode slice temperature detection method

Info

Publication number: CN117839070A
Application number: CN202410007792.9A
Authority: CN
Inventors: 陈凯健; 张军; 孙虎; 惠嘉杰
Original assignee: Jiangsu Hailai Xinchuang Medical Technology Co Ltd
Current assignee: Jiangsu Hailai Xinchuang Medical Technology Co Ltd
Priority date: 2022-12-30
Filing date: 2022-12-30
Publication date: 2024-04-09
Also published as: CN117839069A; CN115970166B; CN115970166A

Abstract

The invention discloses a tumor electric field treatment system, tumor treatment equipment and an electrode slice temperature detection method, wherein the system comprises the following components: at least one pair of electrode pads, each electrode pad comprising a plurality of electrode elements and a plurality of temperature sensors, the plurality of electrode elements being configured into at least three row groups and at least three column groups, a corresponding temperature sensor in each row group being connected to a direct current power supply through a first switch and a voltage dividing resistor, a ground terminal of a corresponding temperature sensor in each column group being connected to a ground pin through a second switch; the adapter is used for carrying out combination control on the first switch and the second switch, acquiring analog signals corresponding to each combination, and determining a combination with analog temperature signals according to the analog signals so as to sample the analog temperature signals detected by each temperature sensor in the electrode slice according to the combination with analog temperature signals. Therefore, on the basis of ensuring the detection of each temperature sensor, the speed of temperature detection is improved, and the occupation of resources is reduced.

Description

Tumor electric field treatment system, tumor treatment equipment and electrode slice temperature detection method

The present application is a divisional application of patent application of the invention with the application date of 2022, 12-month and 30-date, the application number of 202211721864.3 and the invention and creation name of "tumor electric field treatment system, tumor treatment equipment and electrode slice temperature detection method".

Technical Field

The invention relates to the technical field of medical equipment, in particular to a tumor electric field treatment system, tumor treatment equipment and an electrode slice temperature detection method.

Background

Tumor electric field therapy is a tumor therapeutic method which utilizes an electric field generator to generate a low-intensity, medium-high-frequency and alternating electric field to interfere with the mitosis process of tumor cells. The electric field applied by the treatment method can influence the aggregation of tubulin, prevent the formation of spindle body, inhibit the mitosis process and induce the apoptosis of cancer cells.

At present, a tumor electric field treatment system mainly comprises an electric field generating device, a switching device electrically connected with the electric field generating device and a plurality of pairs of electrode plates electrically connected with the electric field generating device through the switching device. The electric field generating device transmits alternating electric signals for tumor electric field treatment to each electrode plate through the switching device, and then the alternating electric field is applied to the tumor part of the patient through the electrode plates to carry out tumor electric field treatment. When the electric field is applied to the body of a patient, heat is accumulated at the corresponding position of the electrode plate, which is applied to the skin, so that the temperature of the electrode plate, which corresponds to the tumor part of the patient, needs to be monitored in real time, and when the temperature of the body surface is too high, the intensity of the alternating electric field needs to be adjusted in time, so that low-temperature scalding of the skin of the patient caused by the too high temperature is avoided.

In the related art, each electrode plate is provided with a thermistor element on its corresponding electrode unit, and a plurality of thermistor elements are connected in parallel with each other, and the temperature change of the corresponding electrode unit is monitored in real time through the resistance change of the thermistor element. For example, in an electrode sheet having 9 electrode units in which 8 thermistor elements are provided and resistance values of the 8 thermistor elements are transmitted through a 10-core cable including 1 alternating current signal line (AC line), 1 ground line, 8 signal lines, the coverage of the thermistor elements in the electrode sheet is about 89% (8/9≡0.89). When the number of the thermistor elements is increased, if the number of the thermistor elements is kept unchanged, the phenomenon of low-temperature scald of the skin of the patient is easy to occur, for example, 8 thermistor elements are arranged in an electrode sheet with 20 electrode units, the coverage rate of the thermistor elements in the electrode sheet is about 40% (8/20=0.4), that is, the temperature of more than half of the electrode units cannot be monitored, and the phenomenon of low-temperature scald of the skin of the patient is easy to occur. If a thermistor element is arranged on each electrode unit to maintain the coverage rate of the thermistor element, more cables with multiple cores are needed, but the cables become thicker, the softness of the cables becomes hard, the difficulty of fixing the cables is increased, meanwhile, the whole weight of the electrode plate is increased due to the increase of the cable cores, the adhesion effect between the electrode plate and the corresponding body surface of the tumor part of the patient is affected, the load of the patient is increased, and discomfort is caused.

Disclosure of Invention

The present invention aims to solve at least one of the technical problems in the related art to some extent. Therefore, a first object of the present invention is to provide a tumor electric field treatment system, which not only can reach 100% of coverage rate of temperature sensors without increasing the number of cable cores, avoid the excessive load of electrode plates, and maintain the application effect of the electrode plates, but also can improve the speed of temperature detection and reduce the occupation of resources on the basis of ensuring the detection of each temperature sensor by screening the switch combination of the first switch and the second switch and performing temperature detection based on the screened switch combination.

A second object of the invention is to propose a tumour treatment device.

A third object of the present invention is to provide an electrode sheet.

A fourth object of the present invention is to provide a method for detecting the temperature of an electrode sheet.

To achieve the above object, an embodiment of a first aspect of the present invention provides a tumor electric field treatment system, including: each electrode plate comprises a plurality of electrode elements and a plurality of temperature sensors, each electrode element can apply an alternating electric field, each temperature sensor is arranged corresponding to one electrode element so as to detect the temperature at the corresponding electrode element, the electrode elements are configured into at least three row groups and at least three column groups, the corresponding temperature sensors in each row group are connected in series and then connected to a direct current power supply through a first switch and a voltage dividing resistor which are connected in series, at least three row group sampling points are formed, the grounding ends of the corresponding temperature sensors in each column group are respectively connected in series with an isolation device, and then connected to a grounding pin through a corresponding second switch, and the isolation devices are used for isolating the mutual influence between any two temperature sensors; the electric field generator is used for generating alternating electric signals and transmitting the alternating electric signals to each electrode slice through the adapter so as to generate alternating electric fields between the electrode slices in pairs, and the adapter is used for carrying out combined control on the first switch and the second switch so as to determine the temperature detected by each temperature sensor according to the sampling signals of each row group sampling point.

According to the tumor electric field treatment system provided by the embodiment of the invention, the plurality of electrode elements on the electrode plate are configured into at least three row groups and at least three column groups, after the corresponding temperature sensors in each row group are connected in series, the electrode elements are connected to a direct current power supply through a first switch and a voltage dividing resistor which are connected in series, at least three row group sampling points are formed, and after the grounding ends of the corresponding temperature sensors in each column group are connected together, the electrode elements are connected to a grounding pin through a second switch; the first switch and the second switch are controlled in a combined way through the adapter, so that the temperature detected by each temperature sensor can be determined according to the sampling signal of each row group sampling point. Therefore, the coverage rate of the temperature sensors can be 100% under the condition that the number of the cable cores is not increased, the electrode plates are prevented from being excessively loaded, the application effect of the electrode plates is kept, the temperature detection is carried out through the switch combination of the first switch and the second switch, the speed of the temperature detection can be improved on the basis of guaranteeing the detection of each temperature sensor, and the resource occupation is reduced. In addition, the grounding end of each temperature sensor is provided with an isolation device to isolate interference, so that the temperature detection precision can be greatly improved.

Further, the adaptor is further configured to determine that the sampling signal is an analog temperature signal when the sampling signal is within a preset signal range.

Further, the adapter comprises a controller and an ADC sampling unit, wherein the controller is connected with the ADC sampling unit, and the controller is configured to perform combined control on the first switch and the second switch, so that the ADC sampling unit performs signal sampling on each of the row group sampling points.

Further, the controller is further configured to determine the number of the plurality of electrode elements, the number of row groups, and the number of column groups according to the sampling signal when it is set that none of the temperature sensor and the circuit connection thereof is abnormal.

Further, the controller is further used for judging whether an abnormal temperature sensor exists in the corresponding electrode slice according to the row group number and the column group number of the electrode elements and the sampling signals.

Further, the voltage dividing resistor, the first switch and the second switch are all arranged in the adapter.

Further, the isolation devices are diodes, and the grounding end of the corresponding temperature sensor in each column group is connected with the anode of the corresponding diode and then connected together through the cathode of the corresponding diode.

Further, the plurality of electrode elements are arranged in a substantially array in a spatial arrangement.

Further, the number of the electrode elements is 13, and the electrode elements are arranged in three rows and five columns or four rows and four columns on the circuit connection.

Further, the number of the electrode elements is 9, and the electrode elements are arranged in three rows and four columns on the circuit connection.

Further, the electrode element is a dielectric element.

Further, the dielectric element is a ceramic plate.

Further, each of the electrode members is provided with a through hole adapted to mount the temperature sensor.

Further, the temperature sensor is a thermistor.

Further, the number of the first switches is greater than or equal to the number of the row groups.

Further, the number of the second switches is greater than or equal to the number of the column groups.

Further, the number of the first switches is 4, and the number of the second switches is 5.

Further, the tumor electric field treatment system further comprises: at least one pair of first connectors, each first connector adapted to connect a respective electrode pad to the adapter; a second connector adapted to connect the electric field generator to the adaptor.

Further, the first connector is configured to connect the adaptor with the electrode pad by means of a connector, and the second connector is configured to connect the adaptor with the electric field generator by means of a connector.

Further, the number of the electrode plates is 4.

To achieve the above object, an embodiment of a second aspect of the present invention provides a tumor treatment apparatus, including the aforementioned tumor electric field treatment system.

According to the tumor treatment equipment provided by the embodiment of the invention, through the tumor electric field treatment system, 100% of coverage rate of the temperature sensors can be achieved under the condition that the number of cable cores is not increased, the electrode plates are prevented from being excessively loaded, the application effect of the electrode plates is kept, and the temperature detection is carried out on the switch combination of the first switch and the second switch, so that the speed and the precision of the temperature detection can be improved and the occupation of resources can be reduced on the basis of ensuring the detection of each temperature sensor.

To achieve the above object, an embodiment of a third aspect of the present invention provides an electrode sheet, including: a substrate; the temperature sensor comprises a substrate, a plurality of electrode elements and a plurality of temperature sensors, wherein the electrode elements are arranged on the substrate, an alternating electric field can be applied to each electrode element, each temperature sensor is arranged corresponding to one electrode element so as to detect the temperature at the corresponding electrode element, the electrode elements are configured into at least three row groups and at least three column groups, after the corresponding temperature sensors in each row group are connected in series, the electrode elements are suitable for being connected to a direct current power supply through a first switch and a voltage dividing resistor which are connected in series, at least three row group sampling points are formed, the grounding ends of the corresponding temperature sensors in each column group are respectively connected in series with an isolation device, and then are connected to a grounding pin through a corresponding second switch, and the isolation device is used for isolating the mutual influence between any two temperature sensors; wherein the first switch and the second switch are adapted to be controlled in combination to determine the temperature detected by each of the temperature sensors based on the sampling signal of each of the row group sampling points.

In order to achieve the above object, a fourth aspect of the present invention provides a method for detecting temperature of an electrode pad, which is applied to the tumor electric field treatment system, and the method includes: the first switch and the second switch are controlled in a combined mode to acquire sampling signals of each row group sampling point; and determining the temperature detected by each temperature sensor according to the sampling signal of each row group sampling point.

According to the electrode slice temperature detection method provided by the embodiment of the invention, based on the tumor electric field treatment system, the first switch and the second switch are controlled in a combined way, so that the temperature detected by each temperature sensor can be determined by the sampling signal of each row group sampling point. Therefore, the coverage rate of the temperature sensors can be 100% under the condition that the number of the cable cores is not increased, the electrode plates are prevented from being excessively loaded, the application effect of the electrode plates is kept, the temperature detection is carried out through the switch combination of the first switch and the second switch, the speed and the precision of the temperature detection can be improved on the basis of guaranteeing the detection of each temperature sensor, and the resource occupation is reduced.

Further, the determining the temperature detected by each temperature sensor according to the sampling signal of each row group sampling point includes: and when the sampling signal is in a preset signal range, determining that the sampling signal is an analog temperature signal, and determining the temperature detected by each temperature sensor according to the analog temperature signal.

Further, after acquiring the sampling signal of each of the row group sampling points, the method further includes: and determining the number of the electrode elements, the number of row groups and the number of column groups according to the sampling signals.

Further, after obtaining the number of row groups and the number of column groups of the plurality of electrode elements, and after a period of use of the electrode sheet, the method further comprises: and judging whether an abnormal temperature sensor exists in the corresponding electrode slice according to the row group number and the column group number of the electrode elements and the sampling signals.

Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.

Drawings

FIG. 1 is a schematic diagram of a tumor electric field therapy system according to an embodiment of the invention;

FIG. 2 is a schematic view of an electrode plate and an adapter according to the first embodiment of FIG. 1;

FIG. 3 is a schematic block diagram of the internal structure of the adapter of FIG. 1;

FIG. 4 is a schematic view of an electrode plate and an adapter according to the second embodiment of FIG. 1;

FIG. 5 is a schematic view of an electrode plate and an adapter according to the third embodiment of FIG. 1;

FIG. 6 is a schematic view of an electrode plate and an adapter according to the fourth embodiment of FIG. 1;

FIG. 7 is a schematic view of an electrode plate and an adapter according to the fifth embodiment of FIG. 1;

FIG. 8 is a schematic view of a sixth embodiment of an electrode plate and an adapter in FIG. 1;

FIG. 9 is a schematic view of an electrode plate and an adapter according to the seventh embodiment of FIG. 1;

FIG. 10 is a schematic view of an electrode plate and an adapter according to the eighth embodiment of FIG. 1;

fig. 11 is a flow chart of a method for detecting temperature of an electrode sheet according to an embodiment of the invention.

Reference numerals:

1000. a tumor electric field treatment system; 100. 100', 100", 100 '", 100"" "', X1, Y1, X2 and Y2, electrode tabs; 111. 111', 111", 111 '", 111"" ', substrate; 112. an electrode element; 113. a temperature sensor; 113A, signal terminals; 113B, ground; 114. a diode; 114A, anode; 114B cathode; 115. 115', 115", 115 '", 115"" ', first cable; 116. perforating; 120. 120', 120", 120 '", 120"" ', and an adapter; 121. a temperature detection switch unit; 122. an ADC sampling unit; 123. a controller; 124. a serial port communication unit; 125. a second cable; 126. an inverter; 130. an electric field generator; 140. 140', 140", 140 '", 140"" "', first connector; 141. a first plug; 142. a first socket; 150. a second connector; 151. a second plug; 152. a second socket; k1, K2, K3 and K4, a first switch; k5, K6, K7, K8 and K9, a second switch; R1-R16, divider resistance; VCC, direct current power supply; GND, ground pin.

Detailed Description

Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative and intended to explain the present invention and should not be construed as limiting the invention.

Referring to fig. 1 to 3, the tumor electric field therapy system 1000 includes: at least one pair of electrode pads 100, an adapter 120 electrically connected to each electrode pad 100, and an electric field generator 130 electrically connected to the adapter 120. At least one pair of electrode sheets may be arranged in pairs on the body surface of the patient, such as 4 electrode sheets X1, Y1, X2 and Y2 in fig. 1, and each two electrode sheets are applied as a pair to the body surface corresponding to the tumor site of the patient. The electric field generator 130 is configured to generate an alternating electric signal, and to switch and transmit the alternating electric signal to at least one pair of electrode pads 100 through the adapter 120, where each pair of electrode pads 100 applies the alternating electric signal to a tumor site of a patient, so that a therapeutic alternating electric field (i.e., a tumor therapeutic electric field) is generated between the same pair of electrode pads 100, and acts on the tumor site of the patient to perform tumor therapy on the patient. The alternating electrical signals applied by two electrode plates 100 in the same pair of electrode plates 100 are different, and the two electrode plates 100 respectively apply a group of alternating electrical signals with opposite polarities and generate an alternating electric field in one direction between the two electrode plates 100. Alternating electric fields of different directions are generated between different pairs of electrode plates 100.

As shown with reference to fig. 2, each electrode pad includes a substrate 111, a plurality of electrode elements 112 disposed on the substrate 111, and a plurality of temperature sensors 113. As shown in fig. 1, a plurality of electrode elements 112 are arranged in a generally array, each electrode element 112 being capable of applying an alternating electric field. The same alternating electrical signal is applied to a plurality of electrode elements 112 of the same electrode sheet 100. Each temperature sensor 113 is provided corresponding to one electrode element 112, and the number of the temperature sensors 113 is equal to the number of the electrode elements 112, that is, the coverage rate of the temperature sensors 113 on the electrode sheet 100 reaches 100%. In this embodiment, each electrode slice 100 includes 13 electrode elements 112, and each electrode element 112 is correspondingly provided with a temperature sensor 113, and the temperature at the corresponding electrode element 112 is detected by the temperature sensor 113.

Each electrode element 112 is provided with a through hole 116, and a corresponding temperature sensor 113 is accommodated in the through hole 116, so that the temperature of each electrode element 112 is monitored in real time, and the phenomenon that the temperature of the body surface of a patient is too high to cause low-temperature burn of the patient due to the fact that the temperature of part of electrode elements 112 cannot be monitored is avoided. As shown in fig. 2, the perforation 116 of each electrode member 112 is located in the middle thereof. In this embodiment, the electrode element 112 is a dielectric element, and preferably, the electrode element 112 is a ceramic plate.

As shown in fig. 2, the plurality of electrode elements 112 and the plurality of temperature sensors 113 disposed correspondingly are each configured in terms of circuit connection structure into at least three row groups and at least three column groups. The number of the electrode elements 112 and the number of the temperature sensors 113 in the same row group are not identical, and the number of the electrode elements 112 and the number of the temperature sensors 113 in the same column group are not identical. The plurality of electrode elements 112 of each row group are all connected in parallel to the same line, and the parallel lines of the plurality of electrode elements 112 of each row group are connected in series to form a line, which is an alternating current signal line (AC line) for transmitting an alternating current electric signal to the plurality of electrode elements 112. It should be noted that the arrangement is for better illustrating the internal portion of the electrode sheet 100 and the electrical connection between the electrode sheet 100 and the adaptor 120, and does not represent the arrangement of the electrode elements 112 in a space structure, which may be a substantially array structure as shown in fig. 1.

Two ends of each temperature sensor 113 are a signal end 113A and a ground end 113B, respectively. The plurality of temperature sensors 113 in the same row group are connected in series, and after one signal terminal 113A at the end of each row group is connected to the dc power source VCC through a first switch and a voltage dividing resistor connected in series, the ground terminal 113B of the corresponding temperature sensor 113 in each column group is connected together and then connected to the ground pin GND through a second switch. The sum of the numbers of the first switch and the second switch is not more than 9, and the tumor electric field treatment system 1000 samples analog temperature signals detected by corresponding one or more combinations of all the temperature sensors 113 of the electrode sheet 100 by configuring the switching timings of the first switch and the second switch, respectively.

In this embodiment, as shown in fig. 2, in terms of the circuit connection structure, 13 electrode elements 112 are configured into 3 row groups and 5 column groups, where the first row group and the second row group are each 5 electrode elements 112, the third row group is 3 electrode elements 112, the first column group to the third column group are each 3 electrode elements 112, and the fourth column group and the fifth column group are each 2 electrode elements 112, i.e., 13 electrode elements 112 are arranged in three rows and five columns. As shown in fig. 2, all the temperature sensors 113 in the same row group are connected in series to form a circuit (such as a circuit A, B or a circuit C) connected to the dc power VCC, the ground terminals 113B of all the temperature sensors 113 in the same row group are respectively connected to the ground pin GND by 5 ground lines (such as ground lines D, E, F, G and H), the ground terminals 113B of all the temperature sensors 113 in the same column group are connected to the same ground line (such as one of the ground lines D, E, F, G and H), and the temperature sensors 113 in each row group are respectively connected in series to a first switch (such as a first switch K1, K2 or K3) and a voltage dividing resistor (such as a voltage dividing resistor R1, R2 or R3) at the dc power VCC terminal, and the voltage dividing resistor (such as a voltage dividing resistor R1, R2 or R3) is closer to the dc power terminal than the first switch (such as the first switch K1, K2 or K3), and each ground line is respectively connected in series to a second switch (such as a second switch K5, K6, K7, K8 or K9). It should be noted that the types of the first switch and the second switch are not limited, and may be a normally open switch or a normally closed switch.

Specifically, five temperature sensors 113 (corresponding to serial numbers 1, 2, 3, 4 and 5) in the first row group are connected in series end to form a line a connected to the dc power supply VCC and connected to the first switch K1 and the voltage dividing resistor R1, the ground terminal 113B of the first temperature sensor 113 (corresponding to serial number 1) in the first row group is connected to the ground line D and connected to the second switch K5, the ground terminal 113B of the second temperature sensor 113 (corresponding to serial number 2) is connected to the ground line E and connected to the second switch K6, the ground terminal 113B of the third temperature sensor 113 (corresponding to serial number 3) is connected to the ground line F and connected to the second switch K7, the ground terminal 113B of the fourth temperature sensor 113 (corresponding to serial number 4) is connected to the ground line G and connected to the second switch K8, and the ground terminal 113B of the fifth temperature sensor 113 (corresponding to serial number 5) is connected to the ground line H and connected to the second switch K9.

Five temperature sensors 113 (corresponding to serial numbers 6, 7, 8, 9 and 10) in the second row group are connected in series end to form a circuit B, which is connected to a direct current power supply VCC and is connected with a first switch K2 and a voltage dividing resistor R2, a grounding end 113B of a first temperature sensor 113 (corresponding to serial number 6) in the second row group is connected with a grounding wire D and is connected with a second switch K5, a grounding end 113B of a second temperature sensor 113 (corresponding to serial number 7) is connected with a grounding wire E and is connected with a second switch K6, a grounding end 113B of a third temperature sensor 113 (corresponding to serial number 8) is connected with a grounding wire F and is connected with a second switch K7, a grounding end 113B of a fourth temperature sensor 113 (corresponding to serial number 9) is connected with a grounding wire G and is connected with a second switch K8, and a grounding end 113B of a fifth temperature sensor 113 (corresponding to serial number 10) is connected with a grounding wire H and is connected with a second switch K9.

Three temperature sensors 113 (corresponding to serial numbers 11, 12 and 13) in the third row group are connected in series end to form a circuit C, the circuit C is connected to a direct current power supply VCC and is connected with a first switch K3 and a divider resistor R3, a grounding end 113B of a first temperature sensor 113 (corresponding to serial number 11) in the third row group is connected with a grounding wire D and is connected with a second switch K5, a grounding end 113B of a second temperature sensor 113 (corresponding to serial number 12) is connected with a grounding wire E and is connected with a second switch K6, a grounding end 113B of a third temperature sensor 113 (corresponding to serial number 13) is connected with a grounding wire F and is connected with a second switch K7.

Each electrode pad 100 further includes a plurality of diodes 114, and each diode 114 is disposed corresponding to one of the temperature sensors 113. Diode 114 has an anode 114A and a cathode 114B. The ground terminals 113B of the corresponding temperature sensors 113 in each column group are connected to the anode 114A of the corresponding diode 114 and then connected together through the cathode 114B of the corresponding diode 114. As shown in fig. 2, a diode 114 is correspondingly connected to the ground terminal 113B of each temperature sensor 113 (corresponding to numbers 1, 6 and 11) of the first column group, and the anode 114A of the diode 114 in the first column group is connected to the ground terminal 113B of the corresponding temperature sensor 113, and the cathode 114B of each diode 114 in the first column group is connected to the ground line D; the grounding terminals 113B of the temperature sensors 113 (corresponding to serial numbers 2, 7 and 12) of the second column group are respectively and correspondingly connected with one diode 114, the anode 114A of the diode 114 positioned in the second column group is connected with the grounding terminal 113B of the corresponding temperature sensor 113, and the cathode 114B of each diode 114 positioned in the second column group is connected with the grounding wire E; the grounding terminals 113B of the temperature sensors 113 (corresponding to the serial numbers 3, 8 and 13) of the third column group are respectively and correspondingly connected with one diode 114, the anode 114A of the diode 114 positioned in the third column group is connected with the grounding terminal 113B of the corresponding temperature sensor 113, and the cathode 114B of each diode 114 positioned in the third column group is connected with the grounding wire F; the grounding terminals 113B of the temperature sensors 113 (corresponding to serial numbers 4 and 9) of the fourth column group are respectively and correspondingly connected with one diode 114, the anode 114A of the diode 114 positioned in the fourth column group is connected with the grounding terminal 113B of the corresponding temperature sensor 113, and the cathode 114B of each diode 114 positioned in the fourth column group is connected with the grounding wire G; the ground terminals 113B of the temperature sensors 113 (corresponding to the serial numbers 5 and 10) of the fifth column group are respectively and correspondingly connected to one diode 114, and the anode 114A of the diode 114 located in the fifth column group is connected to the ground terminal 113B of the corresponding temperature sensor 113, and the cathode 114B of each diode 114 located in the fifth column group is connected to the ground line H. That is, a diode 114 is connected between the ground terminal 113B and the ground pin GND of all the temperature sensors 113 in the same column group, and the diode 114 can effectively prevent the other temperature sensors 113 from affecting the resistance values of the corresponding temperature sensors 113 detected by the switching timing control of the first switch and the second switch.

As shown in fig. 1-3, a first connector 140 is connected between each electrode pad and the adapter 120, the first connector 140 being adapted to connect the respective electrode pad to the adapter 120. Each electrode plate 100 has a first cable 115 electrically connected to the substrate 111 thereof, and the first connector 140 includes a first plug 141 disposed at an end of the first cable 115 remote from the substrate 111 and a first socket 142 disposed on the adapter 120. The first plug 141 and the first socket 142 are push-type spring connectors, that is, the first connector 140 connects the adaptor 120 and the electrode sheet 100 by means of connectors.

As shown in fig. 1, 4 electrode pads X1, Y1, X2, and Y2 are connected to the adapter 120 through one first connector 140, respectively, wherein the electrode pads X1 and X2 are configured as one pair of electrode pads 100 and the electrode pads Y1 and Y2 are configured as the other pair of electrode pads 100. As shown in fig. 3, each first connector 140 is connected to a corresponding one of the lines a1, a2, a3 and a4 in fig. 3, respectively, to transmit an alternating electric signal of a corresponding one direction and a corresponding polarity, so that a therapeutic electric field for treating tumors is generated between a corresponding pair of electrode pads 100 (e.g., electrode pads X1 and X2 or electrode pads Y1 and Y2). It will be appreciated that the lines a1, a2, a3 and a4 are AC lines carrying alternating electrical signals of respective directions and respective polarities and extend into a respective one of the electrode pads 100 to provide respective alternating electrical signals to a plurality of electrode elements 112 of that electrode pad 100. The lines a1, a2, a3, and a4 are connected with a second connector 150 in a direction away from the first connector 140, and the second connector 150 is connected with the electric field generator 130. The electric field generator 130 is powered by a dc power supply, and the dc power supply is subjected to inversion, filtering, and the like to generate two sets of switched alternating electric signals, wherein each set of alternating electric signals is two alternating electric signals with opposite polarities. The two sets of alternating electrical signals generated by the electric field generator 130 are transmitted to the plurality of electrode elements 112 of the corresponding one of the electrode pads 100 through the second connector 150, the corresponding one of the lines a1, a2, a3, a4, and the corresponding first connector 140, respectively. In addition, the electric field generator 130 transmits the dc power to the plurality of temperature sensors 113 of the corresponding one of the electrode pads 100 through the second connector 150, the power and ground lines of the dc power VCC inside the adapter 120, and the corresponding first connector 140, so that the corresponding temperature sensors 113 operate and generate analog temperature signals. In the example shown in fig. 3, an inverter 126 is further provided between the lines a1, a2, a3 and a4, wherein the lines a1 and a3 are connected to one end of the inverter 126 and the lines a2 and a4 are connected to the other end of the inverter 126 to achieve staggered application of alternating electrical signals to the two pairs of electrode pads 100 through the inverter 126.

As shown in fig. 2-3, each first connector 140 is further connected to a set of multi-line temperature-switching acquisition lines a5, a6, a7, or a8, respectively, wherein each temperature-switching acquisition line includes: 4-way lines respectively connected with the first switches K1, K2, K3 and K4 and 5-way grounding lines respectively connected with the second switches K5, K6, K7, K8 and K9. In this embodiment, referring to the example of fig. 2, the first switch K4 is not connected to any one of the temperature sensors 113, and as a preset switch, connection of other types of electrode pads 100 may be adapted, for example, electrode pads 100 including 13 or other number of electrode elements 112 of other circuit connection designs may be adapted, so that the adaptor 120 having substantially the same configuration may be connected to different types of electrode pads 100, and thus the applicability of the adaptor 120 may be improved. The first switch K4 may be disposed in a disconnected state from the first connector 140, and at this time, the number of cores of the first cable 115 of the electrode sheet 100 connected to the first connector 140 may be reduced; the first switch K4 may also be connected to the first socket 142 of the first connector 140, and the number of the cores of the first cables 115 of the electrode sheet 100 may be reduced by connecting only the corresponding first plug 141 to the first socket 142 with one less core of the first cable 115 of the corresponding electrode sheet 100.

As shown in fig. 1 to 3, when the first switch K4 is disconnected or connected to the first connector 140, the first cable 115 of the electrode pad X1 is connected to the first connector 140 in 9 lines. By analogy, the lines of the electrode sheet Y1, in which the first cable 115 is connected to the first connector 140, are 9 lines, the lines of the electrode sheet X2, in which the first cable 115 is connected to the first connector 140, are 9 lines, and the lines of the electrode sheet Y2, in which the first connector 140 is connected, are 9 lines. Accordingly, as shown in fig. 1-2, the first cable 115 between each electrode pad 100 and the corresponding first connector 140 is a 9-wire cable.

As shown in fig. 2 to 3, a plurality of first switches (K1, K2, K3 and K4) and a plurality of second switches (K5, K6, K7, K8 and K9) form one temperature detection switch unit 121, and the temperature detection switch unit 121 and a voltage dividing resistor (e.g., voltage dividing resistor R1 to R4, R5 to R8, R9 to R12 or R13 to R16) connected to the first switch in each temperature detection switch unit 121 are all located in the adapter 120. The adapter 120 includes the aforementioned plurality of temperature detecting switch units 121, voltage dividing resistors (e.g., voltage dividing resistors R1-R4, R5-R8, R9-R12, or R13-R16), an ADC sampling unit 122 for collecting analog temperature signals of the corresponding temperature sensors 113, and a controller 123 for controlling time sequence on-off of the plurality of first switches and the plurality of second switches in the corresponding temperature detecting switch units 121. The controller 123 is configured to perform combination control on the first switch and the second switch, so that the ADC sampling unit 122 obtains analog signals corresponding to each combination of all the combinations; the controller 123 is further configured to determine a combination of analog temperature signals according to the analog signals, and control the first switch and the second switch according to the combination of analog temperature signals, so that the ADC sampling unit 122 samples the analog temperature signals detected by each of the temperature sensors 113 in the electrode pad, and the controller 123 calculates and converts the analog temperature signals collected by the ADC sampling unit 122 into digital temperature signals. When the analog signal is in the preset signal range, the analog signal is determined to be an analog temperature signal, and the corresponding combination of the analog temperature signal is the combination in temperature detection.

As shown in fig. 3, the plurality of temperature detection switch units 121 in the adaptor 120 respectively pass the analog temperature signals to the corresponding channels of the ADC sampling unit 122 through one group of line groups (one group of a9, a10, a11, and a 12). As shown in conjunction with fig. 2 and 3, in the present embodiment, four temperature detection switch units 121 respectively pass analog temperature signals to the corresponding channels of the ADC sampling unit 122 through one group of line groups (one group of a9, a10, a11, and a 12). The temperature detection switch unit 121 corresponding to the electrode pad X1 transmits the analog temperature signal generated by the temperature sensor 113 of the electrode pad X1 to the channels 1-4 of the ADC sampling unit 122 through the 4-way line group a 9; the temperature detection switch unit 121 corresponding to the electrode tab Y1 transmits the analog temperature signal generated by the temperature sensor 113 of the electrode tab Y1 to the channels 5-8 of the ADC sampling unit 122 through the 4-way line group a 10; the temperature detection switch unit 121 corresponding to the electrode pad X2 transmits the analog temperature signal generated by the temperature sensor 113 of the electrode pad X2 to the channels 9-12 of the ADC sampling unit 122 through the 4-way line group a 11; the temperature detection switch unit 121 corresponding to the electrode pad Y2 transmits the analog temperature signal generated by the temperature sensor 113 of the electrode pad Y2 to the channels 13-16 of the ADC sampling unit 122 through the 4-way line group a 12. The controller 123 controls the on-off of the plurality of first switches and the plurality of second switches in the corresponding temperature detection switching unit 121, and causes one first switch (e.g., one of K1, K2, K3, and K4) and one second switch (e.g., one of K5, K6, K7, K8, and K9) to be closed, so that the corresponding temperature sensor 113 generates an analog temperature signal, and the ADC sampling unit 122 collects the analog temperature signal and transmits the analog temperature signal to the corresponding channel of the ADC sampling unit 122 by one line connecting the closed first switches. That is, the ADC acquisition unit 122, when acquiring the analog temperature signal of the corresponding temperature sensor 113 on each electrode pad 100, transfers one line connected to the closed first switch from the corresponding line group (one of the groups a9, a10, a11, and a 12) to its corresponding channel.

The controller 123 controls the on-off of the plurality of first switches and the plurality of second switches in each of the temperature detection switch units 121, and causes one of the first switches (e.g., one of K1, K2, K3, and K4) and one of the second switches (e.g., one of K5, K6, K7, K8, and K9) to be closed to sequentially obtain the analog temperature signals generated by the corresponding temperature sensors 113 in the electrode sheet 100. In this embodiment, as shown in fig. 2, when the controller 123 controls the first switch K1 and the second switch K5 to be turned on and the other switches to be turned off, the ADC sampling unit 122 samples to obtain an analog temperature signal of the first temperature sensor 113 (corresponding to the serial number 1) of the first row group; when the controller 123 controls the first switch K1 and the second switch K6 to be turned on and the other switches to be turned off, the ADC sampling unit 122 samples to obtain the combined analog temperature signals of the first to second temperature sensors 113 (corresponding to the serial numbers 1 and 2) of the first row group; when the controller 123 controls the first switch K1 and the second switch K7 to be turned on and the other switches to be turned off, the ADC sampling unit 122 samples to obtain the combined analog temperature signals of the first to third temperature sensors 113 (corresponding to serial numbers 1, 2, and 3) of the first row group; when the controller 123 controls the first switch K1 and the second switch K8 to be turned on and the other switches to be turned off, the ADC sampling unit 122 samples to obtain analog temperature signals of the first to fourth temperature sensors 113 (corresponding to serial numbers 1, 2, 3, and 4) of the first row group; when the controller 123 controls the first switch K1 and the second switch K9 to be turned on and the other switches to be turned off, the ADC sampling unit 122 samples analog temperature signals of the first to fifth temperature sensors 113 (corresponding to serial numbers 1, 2, 3, 4, and 5) of the first row group. And so on, analog temperature signals generated by the temperature sensors 113 of other row groups can be obtained.

As shown in fig. 2-3, the adaptor 120 further includes a serial communication unit 124, and the serial communication unit 124 transmits the digital temperature signal converted by the controller 123 to the electric field generator 130. The serial communication unit 124 is controlled by the controller 123, and the digital temperature signals converted by the controller 123 are serially transmitted by the serial communication unit 124, for example, to the electric field generator 130.

In this embodiment, as shown in fig. 2, the first switches (for example, K1, K2, K3 and K4) are 4, the second switches (for example, K5, K6, K7, K8 and K9) are 5, and one first switch (for example, K1, K2, K3 and K4) and one second switch (for example, K5, K6, K7, K8 and K9) are turned on, and the remaining switches are turned off, so that 20 combinations can be obtained in this way, respectively: K1K5, K1K6, K1K7, K1K8, K1K9, K2K5, K2K6, K2K7, K2K8, K2K9, K3K5, K3K6, K3K7, K3K8, K3K9, K4K5, K4K6, K4K7, K4K8, K4K9. Before the temperature detection, the controller 123 may predict the analog temperature signal according to the combinations, where the controller 123 sequentially turns on a first switch (e.g., one of K1, K2, K3, and K4) and a second switch (e.g., one of K5, K6, K7, K8, and K9) of the combinations, and acquires analog signals corresponding to the respective combinations through the ADC acquisition unit 122, where some of the analog signals are analog temperature signals, and some of the analog signals are 0 or full scale values. For example, of the foregoing 20 combinations, K1K5, K1K6, K1K7, K1K8, K1K9, K2K5, K2K6, K2K7, K2K8, K2K9, K3K5, K3K6, K3K7 have analog temperature signals, while the analog signals of K3K8, K3K9, K4K5, K4K6, K4K7, K4K8, K4K9 are full scale values. Thus, combinations with analog temperature signals can be screened out based on the analog signals and then stored as combinations at the time of temperature detection. In performing the temperature detection, the controller 123 conducts only the first switch (e.g., one of K1, K2, K3, and K4) and the second switch (e.g., one of K5, K6, K7, K8, and K9) of the combinations of K1K5, K1K6, K1K7, K1K8, K1K9, K2K5, K2K6, K2K7, K2K8, K2K9, K3K5, K3K6, K3K 4, and K3K7, and samples the analog temperature signal detected by the corresponding temperature sensor 113 in the electrode pad through the ADC sampling unit 122, and the controller 123 computationally converts the analog temperature signal collected by the ADC sampling unit 122 into a digital temperature signal, and then transmits the digital temperature signal to the electric field generator 130 through the serial communication unit 124.

In this embodiment, when the controller 123 controls the first switch K1 and the second switch K5 to be turned on and the other switches to be turned off during temperature detection, the ADC sampling unit 122 samples to obtain an analog temperature signal of the first temperature sensor 113 (corresponding to the serial number 1) of the first row group; when the controller 123 controls the first switch K1 and the second switch K6 to be turned on and the other switches to be turned off, the ADC sampling unit 122 samples to obtain the combined analog temperature signals of the first to second temperature sensors 113 (corresponding to the serial numbers 1 and 2) of the first row group; when the controller 123 controls the first switch K1 and the second switch K7 to be turned on and the other switches to be turned off, the ADC sampling unit 122 samples to obtain the combined analog temperature signals of the first to third temperature sensors 113 (corresponding to serial numbers 1, 2, and 3) of the first row group; when the controller 123 controls the first switch K1 and the second switch K8 to be turned on and the other switches to be turned off, the ADC sampling unit 122 samples to obtain analog temperature signals of the first to fourth temperature sensors 113 (corresponding to serial numbers 1, 2, 3, and 4) of the first row group; when the controller 123 controls the first switch K1 and the second switch K9 to be turned on and the other switches to be turned off, the ADC sampling unit 122 samples analog temperature signals of the first to fifth temperature sensors 113 (corresponding to serial numbers 1, 2, 3, 4, and 5) of the first row group. By analogy, analog temperature signals generated by other rows of temperature sensors 113 may be obtained. The serial communication unit 124 is controlled by the controller 123, the controller 123 calculates and converts the analog temperature signals collected by the ADC sampling unit 122 into digital temperature signals, and the controller 123 serially transmits the digital temperature signals of the temperature sensors 113 to the electric field generator 130 through the serial communication unit 124.

Preferably, the temperature sensor 113 is a thermistor. As shown in fig. 2, when reference numerals 1 to 13 are used as reference numerals of temperature measuring points, the resistance of the thermistor corresponding to each reference numeral of the temperature measuring point may be represented by Rtn, for example, the resistance of the thermistor corresponding to reference numeral 1 of the temperature measuring point is Rt1, specifically, the resistance of the thermistor corresponding to the first thermistor of the first row group, the resistance of the thermistor corresponding to reference numeral 2 of the temperature measuring point is Rt2, specifically, the resistance of the thermistor corresponding to the second thermistor of the first row group, and so on.

After obtaining the analog temperature signal corresponding to the temperature measurement point label, the controller 123 calculates the actual temperature of the thermistor corresponding to the temperature measurement point label by the following formula (1), where the analog temperature signal is the resistance value of the corresponding one or more combinations in all the temperature sensors 113 of the electrode pad 100:

where Tn is the actual temperature of the thermistor corresponding to the temperature measurement point reference number n, x is the analog temperature signal corresponding to the temperature measurement point reference number n obtained by sampling, span is the maximum range of the ADC sampling unit 122, for example, when the ADC sampling unit 122 adopts a 16-bit sampling chip, span is 65535, and R is the resistance of the voltage dividing resistor, such as the resistance of the voltage dividing resistor R1, R2, R3 or R4.

The resistance of the thermistor corresponding to the temperature measuring point mark can be calculated by the following formula (2):

it can be understood that by deforming the formula (2), when the resistance value of the thermistor corresponding to the temperature measuring point label is obtained, the analog temperature signal of the thermistor corresponding to the temperature measuring point label can be obtained:

wherein y is the analog temperature signal of the thermistor corresponding to the temperature measuring point mark.

It should be noted that, by selecting a voltage dividing resistor with a suitable resistance value, such as voltage dividing resistors R1, R2, R3 and R4, the current flowing through the thermistor can be limited, so that the temperature rise of the thermistor is avoided from being too large due to the excessive current, thereby affecting the testing precision, and even possibly causing damage to the thermistor when serious.

Specifically, after the switch combination having the analog temperature signal is predicted, the controller 123 controls the temperature detection switch unit 121 to turn on the first switch (e.g., one of K1, K2, K3, and K4) and the second switch (e.g., one of K5, K6, K7, K8, and K9) of the switch combination having the analog temperature signal, so that the analog temperature signal detected by the corresponding thermistor is sampled by the ADC sampling unit 122, and the corresponding temperature is calculated by the above formulas (1) - (3).

For example, the temperature detection of the first row group shown in fig. 2 is taken as an example. The controller 123 firstly controls the first switch K1 and the second switch K5 to be turned on, and the other switches to be turned off, and at this time, samples to obtain an analog temperature signal of the first thermistor in the first row group, the actual temperature T1 of the thermistor can be calculated by the above formula (1), and the resistance Rt1 of the thermistor can be calculated by the above formula (2).

Then, the first switch K1 and the second switch K6 are controlled to be turned on, and the other switches are turned off, at this time, the analog temperature signals obtained by combining the first thermistor and the second thermistor in the first row group are sampled, the resistance value obtained by combining the first thermistor and the second thermistor, that is, rt1+rt2, can be calculated by using the above formula (2), because rt1 is already obtained, rt2 can be calculated, then the analog temperature signal of the second thermistor can be calculated according to rt2 and the above formula (3), and the analog temperature signal is substituted into the above formula (1) to calculate the actual temperature T2 of the second thermistor.

Then, the first switch K1 and the second switch K7 are controlled to be turned on, and the other switches are turned off, at this time, the analog temperature signals obtained by combining the first to third thermistors of the first row group are sampled, the resistance values obtained by combining the first to third thermistors, that is, rt1+rt2+rt3, can be calculated by using the above formula (2), and since Rt1 and Rt2 have been obtained, rt3 can be calculated, and then the analog temperature signal of the third thermister can be calculated according to Rt3 and the above formula (3), and the actual temperature T3 of the third thermister can be calculated by substituting the analog temperature signal into the above formula (1).

Then, the first switch K1 and the second switch K8 are controlled to be turned on, and the other switches are turned off, at this time, the analog temperature signals of the first to fourth thermistors of the first row group are sampled and obtained, the resistance values of the first to fourth thermistors after being combined, that is, rt1+rt2+rt3+rt4, can be calculated by the above formula (2), and since Rt1, rt2 and Rt3 have been obtained, rt4 can be calculated, and then the analog temperature signal of the fourth thermistor can be calculated according to Rt4 and the above formula (3), and the analog temperature signal is substituted into the above formula (1) to calculate the actual temperature T4 of the fourth thermistor.

Then, the first switch K1 and the second switch K9 are controlled to be turned on, and the other switches are turned off, at this time, the analog temperature signals obtained by combining the first to fifth thermistors of the first row group are sampled, the resistance values obtained by combining the first to fifth thermistors, that is, rt1+rt2+rt3+rt4+rt5, can be calculated by using the above formula (2), and since rt1, rt2, rt3 and rt4 have been obtained, rt5 can be calculated, and then the analog temperature signal of the fifth thermister can be calculated by using the above formula (3) and substituting the analog temperature signal into the above formula (1), the actual temperature T5 of the fifth thermister can be calculated.

The temperature detection of the second row group and the third row group shown in fig. 2 is the same as the temperature detection of the first row group, and detailed description thereof will be omitted herein, so that the temperature of the thermistor corresponding to each electrode element 112, that is, the temperature at the electrode element 112, can be obtained.

Thus, by controlling the combination of the first switch (e.g., one of K1, K2, K3, and K4) and the second switch (e.g., one of K5, K6, K7, K8, and K9), not only can the coverage of the temperature sensor 113 be 100% without increasing the number of cores of the first cable 115 be achieved, the excessive load on the electrode sheet 100 can be avoided, the application effect of the electrode sheet 100 can be maintained, but also the speed of temperature detection can be increased and the resource occupation can be reduced by screening the switch combination of the first switch (e.g., one of K1, K2, K3, and K4) and the second switch (e.g., one of K5, K6, K7, K8, and K9) and performing temperature detection based on the screened switch combination.

The controller 123 may also determine the number of the plurality of electrode elements 112, the number of row groups, and the number of column groups based on the combination with the analog temperature signal. As shown in fig. 2, in the case of the electrode sheet, in the foregoing 20 combinations, K1K5, K1K6, K1K7, K1K8, K1K9, K2K5, K2K6, K2K7, K2K8, K2K9, K3K5, K3K6, K3K7 have analog temperature signals, and the combination with analog temperature signals is exactly the same as the number of the electrode elements 112 of the electrode sheet, so that the number of the plurality of the electrode elements 112 in the electrode sheet can be determined according to the combination with analog temperature signals. In addition, in the combination having the analog temperature signal, the number of row groups is the same as the number of first switches appearing, the number of column groups is the same as the number of second switches appearing, and as shown in fig. 2, the plurality of electrode elements 112 are arranged in three rows and five columns, and in the combination having the analog temperature signal, the number of first switches appearing is 3 (first switches K1, K2 and K3), the number of second switches appearing is 5 (second switches K5, K6, K7, K8 and K9), that is, the number of row groups is 3, and the number of column groups is 5, so that the number of row groups and the number of column groups of the plurality of electrode elements 112 can be determined from the combination having the analog temperature signal. In addition, the number of the cores of the first cable 115 may be determined by the number of the row groups and the number of the column groups of the plurality of electrode elements 112 of the electrode sheet 100, and the number of the cores of the first cable 115 is the number of the row groups plus the number of the column groups plus 1 of the plurality of electrode elements 112 of the electrode sheet 100.

The controller 123 is also configured to determine whether the abnormal temperature sensor 113 is present in the corresponding electrode sheet based on the number of row groups and the number of column groups of the plurality of electrode elements 112 and the analog temperature signal. Setting all the temperature sensors 113 and temperature detection circuits of the electrode sheet 100 to be connected normally, as shown in fig. 2, the electric field generator 130 may not be turned on first, at this time, the analog temperature signals generated by each temperature sensor 113 of the electrode sheet are approximately the same, and the corresponding actual temperatures and resistances are also approximately the same, for example, the resistances Rt1, rt2, rt3, rt4 and Rt5 of the thermistors corresponding to the temperature measurement points numbered 1, 2, 3, 4 and 5 are approximately the same, the controller 123 may obtain the actual temperature Tz1 corresponding to the equation 1 by controlling the first switch K1 and the second switch K9 to be turned on, and the other switches to be turned off, because the combined resistances of the 5 thermistors of the first row group are Rt 1=rt2+rt3+rt4+rt5, and the values of Rt1, rt2, rt3, rt4 and rt5 are approximately the same, thus the actual temperature t1 corresponding to the equation 1 may be calculated by controlling the analog temperature signals obtained by sampling; similarly, the actual temperature Tz2 corresponding to the average resistance value of the 5 thermistors in the second row group and the actual temperature Tz3 corresponding to the average resistance value of the 3 thermistors in the third row group can be obtained, and Tz1, tz2 and Tz3 are approximately the same. Therefore, when Tz1, tz2, and Tz3 are obtained, if Tz1, tz2, and Tz3 are approximately the same, no abnormal thermistor or abnormal circuit connection exists in electrode sheet 100; if the difference between Tz1, tz2, and Tz3 is large, an abnormal thermistor or an abnormal circuit connection exists in the electrode sheet 100. Thus, it is possible to determine whether or not the abnormal temperature sensor 113 is present in the electrode sheet 100 based on the number of row groups and the number of column groups of the plurality of electrode elements 112 and the analog temperature signal.

Referring to fig. 1, a second connector 150 is provided between the adaptor 120 and the electric field generator 130, the second connector 150 being adapted to connect the electric field generator 130 to the adaptor 120. The adaptor 120 also has a second cable 125. The second connector 150 includes a second plug 151 disposed at an end of the second cable 125 remote from the adaptor 120 and a second socket 152 disposed on the electric field generator 130. The second plug 151 and the second socket 152 are push-on spring connectors, that is, the second connector 150 connects the adaptor 120 and the electric field generator 130 by adopting a connector mode.

Referring to fig. 3, when the number of electrode pads is 4, the second cable is an 8-core cable, wherein 4 cores are alternating power lines (a 1, a2, a3, and a 4) respectively connected to the 4 first connectors 40 for providing alternating electric signals of corresponding directions and corresponding polarities, 2 cores are a receiving data line RX and a transmitting data line TX electrically connected to the serial communication unit 124 in the adaptor 120, and the remaining 2 cores are a power line and a ground line for providing the direct current power VCC to the at least one temperature sensor 113 of each electrode pad 100. The controller 123 converts the analog temperature signal sampled by the ADC sampling unit 122 and corresponding to the temperature sensor 113 into a digital temperature signal through operation, and the controller 123 controls the serial communication unit 124 to transmit the digital temperature signal to the electric field generator 130 via the second connector 150. That is, the analog temperature signal collected by the ADC sampling unit 122 of the adaptor 120 is converted into a digital temperature signal by the controller 123, and then transferred to the electric field generator 130 via the serial communication unit 124, the transmission data line TX connected to the serial communication unit 124, and the second connector 150. It should be noted that, the controller 123 may also transmit other information such as the number of the plurality of electrode elements 112 in the electrode sheet, the number of the row groups, the number of the column groups, and the presence or absence of the abnormal temperature sensor 113 through the serial communication unit 124, which is not limited herein.

In the above embodiment, by connecting the plurality of electrode elements 112 on the electrode sheet 100 in groups, after the temperature sensors 113 in the same row group are connected in series, the analog temperature signals detected by each temperature sensor 113 are respectively sampled by the first switch (one of K1, K2, K3, and K4) and the voltage dividing resistor (one of R1, R2, R3, and R4) connected in series to the dc power supply VCC, after the ground terminals 113B of the temperature sensors 113 in the same column group are connected together, by the second switch (one of K5, K6, K7, K8, and K9) connected to the ground pin GND, and by controlling the first switch (one of K1, K2, K3, and K4) and the second switch (one of K5, K6, K7, K8, and K9) in combination with analog temperature signals, the electrode sheet 100 can be prevented from being applied with a large load by the electrode sheet 100% without increasing the number of cables of the temperature sensors in the first column group. For example, when the coverage rate of the temperature sensor 113 on the electrode sheet 100 shown in fig. 2 reaches 100%, 15 cores are needed for the first cable 115 in the related art, so that the first cable 115 is thick, has poor flexibility, and has poor application effect, and in this embodiment, the coverage rate of the temperature sensor 113 can be ensured to reach 100% without increasing the number of cores of the first cable 115, so that the temperature of each electrode element 112 in the electrode sheet 100 is comprehensively monitored; meanwhile, before temperature detection, by screening the switch combination of the first switch (one of K1, K2, K3 and K4) and the second switch (one of K5, K6, K7, K8 and K9) and performing temperature detection based on the screened switch combination, the speed of temperature detection can be improved and the resource occupation can be reduced on the basis of ensuring detection of each temperature sensor 113. Moreover, the number of the plurality of electrode elements 112, the number of the row groups and the number of the column groups may also be determined from the combination with the analog temperature signal, and it is determined whether or not the abnormal temperature sensor 113 is present in the corresponding electrode sheet 100.

In other embodiments, as shown in fig. 4, fig. 4 is a schematic structural diagram of an electrode sheet 100 'and an adapter 120' of the second embodiment in fig. 1, and the difference between the electrode sheet 100 of the first embodiment is that: although the electrode elements 112 and the temperature sensors 113 of the electrode sheet 100' of the present embodiment are 13, they are arranged in four rows and four columns in terms of circuit connection. The electrode sheet 100' of the present embodiment has a different number of row groups and a different number of column groups from the electrode sheet 100 of the foregoing first embodiment. The plurality of electrode elements 112 and the plurality of temperature sensors 113 of the electrode sheet 100' each have four row groups and four column groups. Since the electrode element 112, the temperature sensor 113 and the diode 114 are the same as those of the aforementioned first embodiment, the reference numerals of the first embodiment are used. The electrode sheet 100' of the present embodiment has 4 electrode elements 112 and temperature sensors 113 in the first three rows, 1 electrode element 112 and temperature sensor 113 in the last row, 4 electrode elements 112 and temperature sensors 113 in the first column, and 3 electrode elements 112 and temperature sensors 113 in the last three columns. The number of cores of the first cable 115 'of the electrode sheet 100' is 9. The 4 first switches (one of K1, K2, K3 and K4) of the adaptor 120 'are respectively connected to one signal terminal 113A at the end of the corresponding one of the row groups, and the 4 second switches (one of K5, K6, K7 and K8) of the adaptor 120' are respectively connected to the ground terminals 113B of all the temperature sensors 113 of the corresponding one of the column groups, and none of the remaining second switches (K9) are connected to any one of the temperature sensors 113.

In other embodiments, as shown in fig. 5, fig. 5 is a schematic structural diagram of one electrode sheet 100 "and an adapter 120" of the third embodiment in fig. 1, where the electrode sheet 100 "of the present embodiment has the same number of electrode elements 112 and the same number of temperature sensors 113 as the electrode sheet 100' of the second embodiment, and the electrode sheet 100" of the present embodiment has the same number of row groups and column groups as the electrode sheet 100' of the second embodiment, and is different from the electrode sheet 100' of the second embodiment in that: the number of the electrode tab 100 "each row group, each column group electrode element 112 and the plurality of temperature sensors 113 of the present embodiment is different from the number of the electrode tab 100' each row group, each column group electrode element 112 and the plurality of temperature sensors 113 of the second embodiment. Since the electrode element 112, the temperature sensor 113 and the diode 114 are the same as those of the first and second embodiments described above, the reference numerals of the first embodiment are used. The electrode sheet 100″ of the present embodiment has 4 electrode elements 112 and temperature sensors 113 in the previous row group, 3 electrode elements 112 and temperature sensors 113 in the next three row group, 4 electrode elements 112 and temperature sensors 113 in the previous three column group, and 1 electrode element 112 and temperature sensor 113 in the last column group. The number of cores of the first cable 115 "of the electrode sheet 100" is 9. The 4 first switches (one of K1, K2, K3 and K4) of the adaptor 120″ are respectively connected to one signal terminal 113A of the end of the corresponding one of the row groups, and the 4 second switches (one of K5, K6, K7 and K8) of the adaptor 120″ are respectively connected to the ground terminals 113B of all the temperature sensors 113 of the corresponding one of the column groups, and none of the remaining second switches (K9) are connected to any one of the temperature sensors 113.

In other embodiments, as shown in fig. 6, fig. 6 is a schematic structural diagram of one electrode pad 100' "and an adapter 120 '" of the fourth embodiment in fig. 1, and the difference between the electrode pads 100, 100', 100 "of the foregoing three embodiments is that: the electrode sheet 100 '"of the present embodiment has a different number of electrode elements 112 from the electrode sheets 100, 100' of the foregoing three embodiments. The electrode sheet 100' "of the present embodiment has 9 electrode elements 112 and temperature sensors 113, and is arranged in three rows and four columns. Since the electrode element 112, the temperature sensor 113 and the diode 114 are the same as those of the first and second embodiments described above, the reference numerals of the first embodiment are used. The electrode sheet 100' "of the present embodiment has 4 electrode elements 112 and temperature sensors 113 in the first two rows, 1 electrode element 112 and temperature sensor 113 in the latter row, 3 electrode elements 112 and temperature sensors 113 in the former column, and 2 electrode elements 112 and temperature sensors 113 in the latter three columns. The number of cores of the first cable 115 '"of the electrode sheet 100'" is 8. The 3 first switches (one of K1, K2 and K3) of the adaptor 120 '"are respectively connected to one signal terminal 113A of the end of the corresponding one of the row groups, and the 4 second switches (one of K5, K6, K7 and K8) of the adaptor 120'" are respectively connected to the ground terminals 113B of all the temperature sensors 113 of the corresponding one of the column groups, and none of the remaining one first switch (K4) and one of the second switches (K9) are connected to any one of the temperature sensors 113.

As can be seen from fig. 2, 4-6, when the plurality of electrode elements 112 are configured into at least three row groups and at least three column groups, the number of electrode elements 112 in each row group is not identical, and therefore, before performing temperature detection, all combinations of the first switch and the second switch need to be screened to screen out a combination capable of detecting an analog temperature signal, and then temperature detection is performed based on the combination capable of detecting an analog temperature signal. The process of screening for a combination having an analog temperature signal, and performing temperature detection, determination of the number of electrode elements 112, the number of row groups and the number of column groups, and determination of whether or not an abnormal temperature sensor 113 is present in an electrode sheet based on the screened combination having an analog temperature signal is the same, in particular, as described above, although the combination having an analog temperature signal is not exactly the same at the time of temperature detection.

As can be seen from fig. 2, 4-6, the number of the first switches is equal to or greater than the number of the row groups, and the number of the second switches is equal to or greater than the number of the column groups. For example, when the first switches are 4 and the second switches are 5, the first switches K1, K2, K3 and K4 and the second switches K5, K6, K7, K8 and K9 are respectively, but in the example shown in fig. 2, the first switch K4 is in an off state, that is, any one of the temperature sensors 113 is not connected.

In other embodiments, a first switch that is not connected to any one of the temperature sensors 113 and a voltage dividing resistor connected in series with the first switch and/or a second switch that is not connected to any one of the temperature sensors 113 may not be provided. As shown in fig. 7, fig. 7 is a schematic structural diagram of an electrode sheet 100"" and an adapter 120"" of the fifth embodiment in fig. 1, and the adapter 120"" in the present embodiment is not provided with a first switch K4 and a voltage dividing resistor R4 as compared with the adapter 120 of the embodiment shown in fig. 2. As shown in fig. 8, fig. 8 is a schematic structural diagram of one electrode sheet 100"" ' and an adapter 120"" ' of the sixth embodiment in fig. 1, and the adapter 120"" "in the present embodiment is not provided with the second switch K9 as compared with the adapter 120' in the embodiment shown in fig. 4. As shown in fig. 9, fig. 9 is a schematic structural diagram of an electrode sheet 100"" "and an adapter 120" "" of the seventh embodiment in fig. 1, and the adapter 120"" "in the present embodiment is not provided with the second switch K9 as compared with the adapter 120" in the embodiment shown in fig. 5. As shown in fig. 10, fig. 10 is a schematic structural diagram of one electrode sheet 100"" "and an adapter 120" "" of the eighth embodiment in fig. 1, and the adapter 120"" "in the present embodiment is not provided with the first switch K4, the voltage dividing resistor R4 and the second switch K9 as compared with the adapter 120" "" of the embodiment in fig. 6.

The number of the electrode elements 112 and the number of the electrode sheets 100, 100', 100", 100 '", 100"" "' mentioned in the above embodiments may be set according to practical situations, and are only exemplary and not intended to limit the present application.

The invention also provides tumor treatment equipment, which comprises the tumor electric field treatment system 1000.

According to the tumor treatment apparatus of the embodiment of the present invention, by the aforementioned tumor electric field treatment system 1000, it is possible to achieve 100% coverage of the temperature sensor 113 without increasing the number of cores of the first cables 115, 115', 115", 115'", 115"" ", 115" "', avoid overstress of the electrode sheets 100, 100', 100" "", the application effect of the electrode sheets 100, 100', 100", 100'", 100"" ', 100"" "' is maintained, and the speed of temperature detection can be increased and the occupation of resources can be reduced by screening the switch combinations of the first switches (K1, K2, K3, and K4) and the second switches (K5, K6, K7, K8, and K9) and performing temperature detection based on the screened switch combinations, while ensuring the detection of each temperature sensor 113.

The invention also provides an electrode slice temperature detection method which is applied to the tumor electric field treatment system 1000, as shown in fig. 11, and comprises the following steps:

s210, performing combination control on the first switches (K1, K2, K3 and K4) and the second switches (K5, K6, K7, K8 and K9), and acquiring analog signals corresponding to each combination in all combinations.

S220, determining a combination with an analog temperature signal according to the analog signal.

S230, the analog temperature signal detected by each temperature sensor 113 in the electrode pads 100, 100', 100", 100 '", 100"" ' is sampled according to the combination with the analog temperature signal, and converted to obtain a digital temperature signal.

S240, the digital temperature signals are transmitted to the electric field generator of the tumor electric field therapy system 1000, such that the electric field generator determines the temperature at each electrode element from the digital temperature signals.

In step S220, determining a combination with an analog temperature signal from the analog signal includes: and when the analog signal is in the preset signal range, determining the analog signal as an analog temperature signal.

After step S220, i.e. after obtaining the combination with the analog temperature signal, the method further comprises: the number of the plurality of electrode elements 112, the number of row groups, and the number of column groups are determined based on the combination with the analog temperature signal. Here, it is necessary to set that each of the electrode sheets 100, 100', 100", 100'", 100"" "" ', and 100""' has no abnormality in the temperature sensor 113, and that the detection circuit of the temperature sensor 113 has no abnormality in connection.

In this embodiment, after obtaining the number of row groups and the number of column groups of the plurality of electrode elements 112, and after the electrode sheets 100, 100', 100", 100 '", 100"" "' are used for a period of time, the method further includes: whether an abnormal temperature sensor exists in the corresponding electrode sheet 112 is determined based on the number of row groups and the number of column groups of the plurality of electrode elements 112 and the analog temperature signal.

According to the electrode sheet temperature detection method of the embodiment of the invention, before temperature detection is performed, the first switches (K1, K2, K3 and K4) and the second switches (K5, K6, K7, K8 and K9) can be subjected to combined control, analog signals corresponding to each combination in all combinations are obtained, and the combination with the analog temperature signals is determined according to the analog signals; in performing temperature detection, the analog temperature signals detected by each of the temperature sensors 113 in the electrode pads 100, 100', 100", 100 '", 100"" ' are sampled according to a combination having analog temperature signals, an analog temperature signal is obtained, and the analog temperature signals are transmitted to the electric field generator 130 of the tumor electric field therapy system 1000, so that the electric field generator 130 determines the temperature at each electrode element 112 from the analog temperature signals. Thus, not only can 100% coverage of the temperature sensor 113 be achieved without increasing the number of the first cables 115, 115', 115", 115 '", 115"" ' cores, the electrode sheets 100, 100' are prevented from being excessively loaded, the application effect of the electrode sheets 100, 100', and through screening the switch combination of the first switch (K1, K2, K3 and K4) and the second switch (K5, K6, K7, K8 and K9) and carrying out temperature detection based on the screened switch combination, the speed of temperature detection can be improved and the resource occupation can be reduced on the basis of ensuring the detection of each temperature sensor 113.

It should be noted that the logic and/or steps represented in the flowcharts or otherwise described herein, for example, may be considered as a ordered listing of executable instructions for implementing logical functions, and may be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device, such as a computer-based system, processor-containing system, or other system that can fetch the instructions from the instruction execution system, apparatus, or device and execute the instructions. For the purposes of this description, a "computer-readable medium" can be any means that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device. More specific examples (a non-exhaustive list) of the computer-readable medium would include the following: an electrical connection (electronic device) having one or more wires, a portable computer diskette (magnetic device), a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). In addition, the computer readable medium may even be paper or other suitable medium on which the program is printed, as the program may be electronically captured, via, for instance, optical scanning of the paper or other medium, then compiled, interpreted or otherwise processed in a suitable manner, if necessary, and then stored in a computer memory.

It is to be understood that portions of the present invention may be implemented in hardware, software, firmware, or a combination thereof. In the above-described embodiments, the various steps or methods may be implemented in software or firmware stored in a memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, may be implemented using any one or combination of the following techniques, as is well known in the art: discrete logic circuits having logic gates for implementing logic functions on data signals, application specific integrated circuits having suitable combinational logic gates, programmable Gate Arrays (PGAs), field Programmable Gate Arrays (FPGAs), and the like.

In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Furthermore, the terms "first," "second," and the like, as used in embodiments of the present invention, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or as implying any particular number of features in the present embodiment. Thus, a feature of an embodiment of the invention that is defined by terms such as "first," "second," etc., may explicitly or implicitly indicate that at least one such feature is included in the embodiment. In the description of the present invention, the word "plurality" means at least two or more, for example, two, three, four, etc., unless explicitly defined otherwise in the embodiments.

In the present invention, unless explicitly stated or limited otherwise in the examples, the terms "mounted," "connected," and "fixed" as used in the examples should be interpreted broadly, e.g., the connection may be a fixed connection, may be a removable connection, or may be integral, and it may be understood that the connection may also be a mechanical connection, an electrical connection, etc.; of course, it may be directly connected, or indirectly connected through an intermediate medium, or may be in communication with each other, or in interaction with each other. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to specific embodiments.

While embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are illustrative and not to be construed as limiting the invention, and that variations, modifications, alternatives and variations may be made to the above embodiments by one of ordinary skill in the art within the scope of the invention.

Claims

1. A tumor electric field therapy system, comprising:

each electrode plate comprises a plurality of electrode elements and a plurality of temperature sensors, each electrode element can apply an alternating electric field, each temperature sensor is arranged corresponding to one electrode element so as to detect the temperature at the corresponding electrode element, the electrode elements are configured into at least three row groups and at least three column groups, the corresponding temperature sensors in each row group are connected in series and then connected to a direct current power supply through a first switch and a voltage dividing resistor which are connected in series, at least three row group sampling points are formed, the grounding ends of the corresponding temperature sensors in each column group are respectively connected in series with an isolation device, and then connected to a grounding pin through a corresponding second switch, and the isolation devices are used for isolating the mutual influence between any two temperature sensors;

An adapter for controlling the first switch and the second switch in combination so as to determine the temperature detected by each of the temperature sensors from the sampling signal of each of the row group sampling points, and an electric field generator for generating an alternating electric signal and transmitting the alternating electric signal to each of the electrode pads through the adapter so as to generate an alternating electric field between the paired electrode pads.

2. The oncological electric field therapy system according to claim 1, wherein the adapter is further configured to determine the sampling signal to be an analog temperature signal when the sampling signal is within a preset signal range.

3. The oncological electric field therapy system according to claim 1, wherein the adapter comprises a controller and an ADC sampling unit, the controller being connected to the ADC sampling unit, the controller being configured to control the first switch and the second switch in combination so that the ADC sampling unit performs signal sampling for each of the row group sampling points.

4. The oncological electric field therapy system according to claim 3, wherein the controller is further configured to determine the number of the plurality of electrode elements, the number of row groups and the number of column groups based on the sampling signal when the temperature sensor and the circuit connection thereof are set to be free from abnormality.

5. The oncological electric field therapy system according to claim 4, wherein the controller is further configured to determine whether an abnormal temperature sensor is present in the respective electrode pad based on the number of row groups and column groups of the plurality of electrode elements and the sampling signal.

6. The oncological electric field therapy system according to claim 1, wherein the voltage dividing resistor, the first switch and the second switch are all disposed in the adapter.

7. The oncological electric field therapy system according to any one of claims 1-6, wherein the isolation devices are diodes, and wherein the ground terminal of the corresponding temperature sensor in each of the column groups is connected to the anode of the corresponding diode and then connected to the cathode of the corresponding diode.

8. The oncological electric field therapy system according to any one of claims 1-6, wherein the plurality of electrode elements are arranged in a substantially array in spatial arrangement.

9. The oncological electric field therapy system according to claim 8, wherein the plurality of electrode elements is 13 and is arranged in three rows, five columns, or four rows, four columns on the circuit connection.

10. The oncological electric field therapy system according to claim 8, wherein the plurality of electrode elements is 9 and arranged in three rows and four columns on the circuit connection.

11. The oncological electric field therapy system according to claim 1, wherein the electrode element is a dielectric element.

12. The oncological electric field therapy system according to claim 11, wherein the dielectric element is a ceramic sheet.

13. The oncological electric field therapy system according to claim 1, wherein each of the electrode elements is provided with a perforation adapted to mount the temperature sensor.

14. The oncological electric field therapy system according to claim 1, wherein the temperature sensor is a thermistor.

15. The oncological electric field therapy system according to claim 1, wherein the number of first switches is greater than or equal to the number of row groups.

16. The oncological electric field therapy system according to claim 1, wherein the number of second switches is greater than or equal to the number of column groups.

17. The oncological electric field therapy system according to claim 1, wherein the first switches are 4 and the second switches are 5.

18. The oncological electric field therapy system according to claim 1, further comprising:

at least one pair of first connectors, each first connector adapted to connect a respective electrode pad to the adapter;

a second connector adapted to connect the electric field generator to the adaptor.

19. The oncological electric field therapy system according to claim 18, wherein the first connector is configured to connect the adapter with the electrode pad in the manner of a connector and the second connector is configured to connect the adapter with the electric field generator in the manner of a connector.

20. The oncological electric field therapy system according to claim 1, wherein the number of electrode pads is 4.

21. A tumor treatment apparatus, comprising: the oncological electric field therapy system according to any one of claims 1-20.

22. An electrode sheet, characterized by comprising:

a substrate;

the temperature sensor comprises a substrate, a plurality of electrode elements and a plurality of temperature sensors, wherein the electrode elements are arranged on the substrate, an alternating electric field can be applied to each electrode element, each temperature sensor is arranged corresponding to one electrode element so as to detect the temperature at the corresponding electrode element, the electrode elements are configured into at least three row groups and at least three column groups, after the corresponding temperature sensors in each row group are connected in series, the electrode elements are suitable for being connected to a direct current power supply through a first switch and a voltage dividing resistor which are connected in series, at least three row group sampling points are formed, the grounding ends of the corresponding temperature sensors in each column group are respectively connected in series with an isolation device, and then are connected to a grounding pin through a corresponding second switch, and the isolation device is used for isolating the mutual influence between any two temperature sensors;

Wherein the first switch and the second switch are adapted to be controlled in combination to determine the temperature detected by each of the temperature sensors based on the sampling signal of each of the row group sampling points.

23. A method of electrode sheet temperature detection, characterized by being applied to the tumor electric field therapy system according to any one of claims 1 to 20, the method comprising:

the first switch and the second switch are controlled in a combined mode to acquire sampling signals of each row group sampling point;

and determining the temperature detected by each temperature sensor according to the sampling signal of each row group sampling point.

24. The electrode pad temperature detection method according to claim 23, wherein the determining the temperature detected by each of the temperature sensors from the sampling signal of each of the row group sampling points comprises:

and when the sampling signal is in a preset signal range, determining that the sampling signal is an analog temperature signal, and determining the temperature detected by each temperature sensor according to the analog temperature signal.

25. The electrode pad temperature detection method according to claim 23, wherein after acquiring the sampling signal of each of the row group sampling points, the method further comprises:

And determining the number of the electrode elements, the number of row groups and the number of column groups according to the sampling signals.

26. The electrode sheet temperature detection method according to claim 25, wherein after obtaining the number of row groups and the number of column groups of the plurality of electrode elements, and after a period of use of the electrode sheet, the method further comprises:

and judging whether an abnormal temperature sensor exists in the corresponding electrode slice according to the row group number and the column group number of the electrode elements and the sampling signals.